Document kNw8V47QgvN46B75DjwGE30n

Maas 3288 470 AR2A6 _ R82 Dwg --~ TRADE SECRET Study Title 90-Day Gavage Study i'nHR-a2t5s42w5i:thSOunbec-hGreonneircTaotxiionciRteyproductionEvaluations Volume 3 of 5 Laboratory Project ID: DuPont-11418 `TEST GUIDELINES: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (AUG-1998) --_ AUTHOR: Susan A. MacKenzie, V.M.D., PhD,, D.AB.T, ! STUDY COMPLETED ON: August 1, 2003 PERFORMING LABORATORY: E.L du Pont de Nemours andCompany HaEslkkteolnlRLoaabdo,rPa.tOo.ryBfooxr H5e0alth and Environmental Sciences Newark, Delaware 19714-0050 `WORK REQUEST NUMBER: SERVICE Cope Numser --~ TTT em nosy Sant Som TRH 2505.4D2a5y;GavSaugbeekSroundiye iTnoRxaitcsitwyith OneGeneration Reproduction Balusions -- Dupon11418 --_ APPENDIX D INDIVIDUALFOOD CONSUMPTION --~ -= `Company Saritzed. Dossnot contain TSCA Call 2905-4D2ay5:GSuabchSrtvoundiyeaiTnoRxagitcsitweyithOne-Generation Reproduction Evaluations ~ INDIVIDUALFOOD CONSUMPTION Dupont11418 Critical Dates EXPLANATORY NOTES Day 72 Lwaesrtedraeypodratteadfwriotmhtthheemsaulbceharnodnifcemorailceiattysandiemsailgsn.atBedodfoyrwreeiprgohdsucatnidoncleivnailcuaaltions oinbstehrevRateipornosducocltlievceteTdoxdiucroilnoggtyheseccothiaobni;tDatoisoen vaonldupmoesst-amdamtiinnigstpeerreidoddsurairnegretphoerted cohabitation and post-mating periods are documented in study records. . Day90 Ladaysofttest substance adminisftorramatlieaonnd female rats designatfeord : one-month and three-month recovery periods. Day91 Last day of body weight and food consumption data collection for male and female rats designatedforthesubchronic toxicity evaluation. + Last dayoftest substance administration for male rats designated forthe subchronic toxicity evaluation. Day92 Male rat designated for the subchronic toxicity evaluation were sacrificed. Last dayoftest substance administration for female rats designatedforthe subchronic toxicity evaluation. --~ Day93 Female rats designatedforthesubchronic toxicity evalwueraestacriifoicend. Day 126 + Last dayofbody weight and food consumption data collection for rats designated fortheone-month recovery period. + Last dayoffood consumption data collection for rts designated for the three-month recovery period. Day 127 Male and female rat designated for the one-month recovery were sacrificed. Day 182 Maleand female rats designated for blood fluorine level evaluationweresacrificed. Abbreviations `mgga/nkgmd=amyg=/kggr/admasy/animaliday Note . Absence of data indicates the animal was not alive at the time of data collection. -- --_-- | Company Sanitized. Does not containTSCA CBI TM og z Be mmnIRRIREIRRREEER 382 3 Hfe eCInnNIEEMIRRERLGS mEREIRLNINRERAREE iii EnITREELENRGERS | be ~ 3IJEi EnENNTERRas 8 For Ri be EER EE ol 1| i moensesrmEnIEREERR I seems 23 $.5: IRRIREIMeNhIsmAqIaMqeEeInaRsRaRinAaEnIntNiEiRnaNsRAeeRneaRgEs BglE. i LN, nnnmnRRRRRR a ani 358 TTT igesssssassrasszzringeasiisssizaaesis: [---- ~ = Ao mm 1 ijE jd mus 1fio EE ~ [ ji BE 8 i pi mE 3 ck 8 ri man lo |I I mam g3g. 8ib GREE o OR d ann 35M : fo. ~~ al E 32 Zdcsndasdsasdnassgdnsndsssssniidaes 1 BB mnnERRSRRRER i $i3h LIMIRININNESEGEES $13d CEIIRLIILIARRLREE ~ 5FHLi SRRRAREE ; die sormnmmammnmuas i ba fin soossssEEERRREEGG 1i : $n CEILINGS go i} 8 iz i HRIl, E rrree if wh Mb oosannnREnEREEE omySs BRTIRASSH rr =| :a 3: AIRINnoaG maaer 3k HBeE nnERRER BB mnEENSRTRIEEE iH %Bs nnRNTRERENS ELCi mEIHRRRRERIGES _ Pil 3 | LE TILIA ' i8] 33T:y3l8z dvReiaRdnieiiassinaarsaiindndsssasnsidancasrgaeadasnsrsaeslananyd 8i iiH FERRITIN z F387 [dndiRRsdAdsanansnfisiRdnanannERERR i5, womw : GID Br mRnnERRI EERE CompanySoni, Gos ARATROATEH z iBite CIRRERRSRESGRER iBeH nnmmemsRaEsaaan Br nnn Be amnmmmseERaaamEan 1k PR Etr ereee ee - Pil , 3I iR i nmmrmnL unsnnosn Be nmennEamaaaa )1 1Br RRR RARE Siip $L.2. 27 Imnmesoonanatnnannsaannaasansasenss CompanySerb, BonsTOACEA ~~ = 4 pe mum 1h iH oman ji aa i Bom iH di IE - tik 1 pie nme 3 Cah & 1B 8 ie mus: 3 1H - IIo 233, g83k8% dandss cftE CEAe ers iy al 45 TE Fin 3 " Company Sens eset cnanToonGo ~ 2| J i i ih 5 Biz ~ jie dpi 1| ih 8 Zi i mmm Ja fiz REiERidAied |HR be, aeemnmn um wn ia 5 Fre ji ma pre nn Comey ent, coston 1 3 3 ~ i #0 5{I Tg ifihn GRRE ihfin 837 nds BARRA PELE fi pi in Eu i fHhae mam pe mam 3k i3: anda o 23 e ir. s aeesen : iF % . . Company Stas. DoeconTaSOAnGBI =| 3 is ih iBihz ~ 5tiik ; | ii |b | 3 iiiH df ope mmEEERE smmRER moaGe dopmunnam 5 TE epasasnnsaesnngasgzenassgninassg CompanySanitized. Doesnot conTtSaCAiCBnI ~ =| 3 3 ihiE ie th ~ 5Piiks ih igi ch aq i. 2J gn spmessessmennas 3 iE f2dRaAnEERNRARS 3 3g &I 0 rer - ig, wm LM ie fmm : i) iz5 i ii j i $s sspamsananansemEannaasieanangnan `CompanySanitized. DoesnotcontTSaCAiCn BI ~ og H iih83% is ih 5 BE: ~ |e i Bi WN:i| HCE = w 1 oie PH By 24: B : 2| fic} smmawam mm _ m SQRAIRRARARANR niiddidensans on HEE i "aaa |a28n8n8 ws ws i. 54s `Company Sanitized. DoesnotcontTSaCAiCBnI H fas mal i 3: iadses ih ~ IE : sf EEE pie EEE i BH i ik"sek mmm 1 mns ] 34 54 Bipp - sp ig giehtram =f um ~ =| a 482 Zidssddmmisddgisssnsdidiadiinadnagtetas ifi IIIS $s IIIA 34 iBe RENEE ~ sfijl pERESERERERNRRRRRR i HE FRR ' I ois I fie msmensnuusHmEsEmaEm i 2 5B5B I EEREREE REEn CE EEE EEEn ERE EEREELa E 38d 5 BI: SIRENS i % ! SiiiainEasiisiiERililiianidEianiaiia Company Sanitized. Doesnotcontain TSCA CBI : fie ama wo 1 num B= 333334 fmm i 3B: aa ~ jE 3 Lsii: mam 10 faCaem mam I sas 8 i g EI b HT3lI E5i3n.e2oadnaeedess 3 . Compr sn, T5oA GO ~ og | sosesssmanmEEms i i$3s IIEARNEANEIIIERLANRGIREAEER mBr emnmnESIImIERIEs Be mmm Hy PI EERE Pile aI +i5m soonsmmenERnRennn C Biz BIN anna A Ra aaana as .J Ii nwnmmsEnenmmEnENEn PR 5 bossa ial slic qm $ sorzgzsassassasssanscazzagsnszesIia CompanySots, bos econ3AGBI ~a 3 i AsRndasssaiesdisdesddsdansninidind iBh comsnEESREnIE iiB pnnEERmERRERE fe mnTmIEERERERREE iH i nRnmmIEEEEmEEREEE file 5 {| Bip edstRestessesiiansdiissastinn 3 3B 38 fiil SEEEeaEnaEnEaRRAnEnAEREIaEnEdEEaEEnEIEERENEEeELaEEnERnEaEETLREEASse i } Hie INGLES i i } Ob mms 5 23 Eir3,7 d7d2ss3a2dn2sm9s0ss9s7sa7t1ss3ns2a7idI9dn0aes9siiH9n8sai0tn1nsn1g Zdzls Bi . al gE GSM risssenmasesnsiansanonanoangass Company Sanitized. Doss not contain TSCA OBI ~ og | wm sows i i EERE i ERmEEIERERRRa ji oo iBiis SRaSdSnadNdSiIdSiisadInieIdiisnsandiirdioioisdensssianndadrnednnigadsnaens i EEE ~ fil ; : LE NEANRARRNRAANRRNRARARANANEARIARNARRARAS ii i ERNE | 1 fe a mmrERmEREEEER mmm 2 2 Sas E 3 B38 IiEIInrEaiunnInIInaIiiaaaaa: FE 31 ol [R EEE EeEE E orpetn, betranscnco I = 1H Bs mmm 3h iH i Bann i 8s Imm ~ iil | i mm 1g i fa sum 3 iH dom 4a =F ig, al88% amndsn So 3 35. 8? 133s 9 eT $ ' Sonyse00, emir o;g 3 igihs ii ~ 5ti3k3 I i| E 1pidn HE 0 EneF sAamesmaseinwnausnmii 3 Bl g83E% dzogssgdsadadan iEl ida nmin HEE ma i5ada ` ffriee ' mu mn EEEEDS mn 33: 1 Sizgdieitnanuanintananateaaiintuinn `CompanySanitized. DoesnotconTtSaCAiCnBI ~~ 3 z i: fins He fn 1 ~ j5i: Em fg 1d mm 1 gi hE fi smo i Bo oaEn I LP 52% 82: rasa 0 3 3 i: ua : : : Company Sante, Doesro containTSGAOB 3 ~ =| 3 iBah itFES 83% 5 85 ~ || Yt 3iz 16 RE I3 |HI Eo Oe ammanmm $ i5s8 asiodmiodidsdideasnzdaisasge 5TIs == 2 3mm 2 ome 2 gf 2 2 ' : CompanySanitized. Doesnotcontain TSCA CBI rm =| 3Z| i38h: 3i8h2 5 33 ~ ii 5 | 3 2 3 Eis q 3h 4 ge mmmmann Boi I= mamma . 3 3 aiIMlo oGFs ommnnans CompanySanitized. Doesnot containTSCA CBI ~ og 5 i th ihFE 837 s iin 3 i8% ~ | jE Fl 1 3 i53s | okii AAngaas Senses JRREARS i EER RRARARA 2saAssaeRnRs : mmm 1H S3aiiaanasaaad fags 58 IS 53 2s 83% Fidddassdsdenas i . Be 3 EEEELHHS 4 = 8 IIiiEnIEaRa Erp i ih: IW msesnesranienrnenessannnnes Company Santas. Does motcontan TSA GBI ~= :Z fi a ih om 1h | Li 5 gm - ik 5 fg pi g if I oii = i i ow agJl ign m s8 compra Soinsron 910.2D5a42y5:GavSaugbechSruondiyciTnoRxiacstywithOne Generation Reproduction Evaluations DuPont 11418 ~ APPENDIX E INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY RECORDS -- - = `Company Sanitized. Does not contain TSCA CBI 9F0-2D5a42y5:GavSaugbechSruodnyi iTooRraitcsiywith One. Generation Reproduction Evalustions --~ Dupont11415 INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY RECORDS Criteal Dates EXPLANATORY NOTES Day 72 L`awesrtedraeypodrateadfwriotmhtthheemsaulbceharnodnifcetmoaxilcirtaytsandiemsailgsn.atBedodfyowreeipgrhotdsucatnidoncleivnailcuaaltions iobnstehrevRateipornosduccotlilvceteTdoxdiucroilngotghyesceocbtiaobni;taDtoisoen vaonldpumoesstmaadlmiinnigstpeerreidoddsarairengretphoerted cohabitation andpostmating periods are documented in study records. Day 90 L`aosnte-dmaoynotfh aensdtthsruebsetmaonncetahdmrienciosvterraytipoenrifoodrs.male and female rats designated for Day91 + fLeamsatledaryaotsfdbeosdigynawteeidghftoratnhdefsouobdchcroonnsiucmtpotxiiocintydaetvaalcuoaltlieocnt.ion for male and Lsausbcthrdoanyicoftotxeistcistuybesvtaalnucaetiaodnm.inistration for male ats designated for the Day92 + Male ats designate for the subchronic toxicity evaluation were sacrificed Lassubtchdraoyniocftteosxticsiutybsvtaalnucaetaidomni.nistration for female rats designated for the ~ Day 93 Female ats designated forthe subchronic toxicity evaluation were sacrificed. Day 126 + dLeassitgdnaaytoedfbfoordthy woenigeh-tmoanntdhfroeocdovceornysupmerpitoid.on data collection for rats + tLharseted-amyoonfthfroeocdovceornysupmerpitoid.on dat collection for ras designated fo the Day 127 Male and female rats designated for the one-month recovery were sacrificed. Day 182 Male and femaleats designatedforblood fluorine level evaluation were sacrificed. --~ Ee Company Sanitzed. Doesnotcontain TSCA CBI ~~ 2 i2 g . Posf gl gr gb gt dp i] o3i: $58 zi: fss 3c: fcE 3a: gcd oi: iid 4 AF Fis dy: Br: ii: dg | LHL HEHE Boioafigf difip: np13 b ii ii38; PPa oir2 liiafti2 iiiii2 iiiiting,iiagial,3a 2A4. ddisrdiiiiesisiitiieisiillieisiitliaiciiiil sh is : : : : EHD gi - - . - Compa Satz. comin TSA! ~~ wf isiiresisatiaianiaianain B01 atiestdinig doied I 3s: Iss 3s: 3s: 1: ' zoF f$r3e3 f83x8:3 B$3r5y5 fr3y3 i$5 i| 12 f1i3zz Z13:3% ff3g3g, f133z8z I1%j Hof drs dzg,, digi dif od: | 2 2 2 3% 2 z 2 2 d , JH dPlgEdrlirdiieglsdrdisdiiiiiiiicisliieiisiiisoieciiiciicicigeiidsi i iF g ~Ha i :0 g 2 2 : IE Company Santas. DosscoTnSCAeGH! ~ 2 ghseizigiiisieiiziziiaoe g Iol : fIgF i i8 og{iiiiff ogiiidf 32 ; AF o fsx fpr fog i 1:FI 118 PFriig:s di144g | =I | 03RB E 2 N e E 2 BRi EH.E2 EEEl p0u 0 drip ffl Bifp pdlip adlid di difd iso : 24: 538 5% 53 255338 55 4:81 24 #9) ~a2g4E iE El. s. . . . - - = CompanySaeed. BossrotaTStCA e ~~ = 4 g ghrimaiaialelelalelaled i = [EE if g o0i4erS5ss: p3fosassrs pF poF pp EEE oFof0o%fooo:fofo%o% : Perper bbb 8 F-P ei2 Ploeg2 2 2oc 2i.i2 .i2 .i2 J Csiigioirpiritiiririg Bof8, fSs iiplosis NFEiRi EIl ERa RIiILnGEnS 34 8 g 88 8 ~ &3% 5 = = ======= J ---- ~~ = 5: igi5 ei2 rd2 ad2 ri2 ni2 ni2 ecd2 ni3 eni2n ~i i g i ET % 3 % % 3 3 : f| 3 g [EzT fTE 2I xIz 3 2 & i: T1011 11_ i. 1 3 ];0: 4+0o4: io2oz oad iaiy i2ii ioa d "ordeieiiieqeieiteiiel Jgiil, PfRrsEiReRiRsBiRiBiReRrRiRvRiDfIiReBisiigia Si i888 3% 3 3 % 3 3 EH iE 3 49 2 . " --~ #8[% 3 cons Gosiaaonc ~ 3i5 sF8efefefeinaiandantant i i i222 J Phi bib n : 33 5 z ts 5 ` 3| f & & 2 &3 iy i; 3; 2 ii tg 1% if EI A I A A HO HS Ugd 1: f& p2tgi2 p2ty=tin2iis2iin2i3te2 CEe$EdfRirEjiitEiiiRrfiRitgdRiiiRsiRdidifgEiigiEigqRiiiiEgy Bstf, DPRHRHREEEEREEDGIsidsniiisiglsid 3 ig 0: $3 3 @ 8 3z : i Ee ve ee eee ~ 41 Fx = = oz = = x = - CompanySeiten GotanTSEAGEH ~ : : J EEF 2 R5 Ifr5EfTIss EIE$xe EEdsgsEEdgs os ds dp 4: i: 4s iz PP= oiida2rpfia2igii2iaggii2iitgeie2dg SJY _ edri3 gdigiiFE gsRiiEiiR cgeiliz igiiliFiglgiiizlidg : 4, drissibrirsiseiisii 543 i:id 2 gg gi g ~ 34% 5. sss CoS mA ~3 i sirnsifenssloinaiadnaie 2 ~~ 3 ii i 54 id 3 3 1: pif 1ii gid 3 FI HEE tod 383 HI EEE fr: Ey EE 35 of f33ig, EPE1R3, 1fd383, l3i3: Boi odsiil dil dist digg i} 11a g2ridiiib2 igv2 ingbe3 ipeinieb,1iivnaenned2y JHd rfEddidifiiaeisddiiifiesriiitfioisditiicsd $8, dbrsiiiirridisriiissii So ia : 5 5 aG2od i2 ~Eg i= 3 8 i = - = Commi, Sha ~~ =| z35 shefrssiossinssiaciaing i Iii 33 g3 g$5c5d Ftsgss Fs: fod Iss FE LEE $53 : 3 fpr fry dy By iy df 233 Zig Zig Iii Zi J5 oi@ ffr:i dIp:f d1i#:% 4154:% iiE =] = 2g 2 2 2 +fofc Ffrafgididzdlgiiidzcigidilziigiiiliigaiaiicl fl. diisshizsiizaiizsiiisg 343 2i8i3s zg g ig g2 sl Da 8 3 8 8 Company Sartzad. Doss net contin TSCA CBI ~= 2 3 3 EI Pod IEEEREPERERER EEE ESSE-T i 35 $iiE gizt IEEE ~ 3 fis FE HEHEE EiFHE pi5z:4 8 i: HHII 88 fs B: g dss f ;= 53 f3 og | Fajitiai TPoFg d0s3r% d1i8:% P3P.G:1y dIsisi ; 33 oSfE.fF33 EfaE y oT piiRoiElEEoE gy Z iiid g3 ; 33 3% 7 3 ff2 $ Bl feF dii cei lgdE i opy yioii yodfe dPaiicf oqc; - B2il, diiisis iii 33i 10zss:i 24 i3 2 8 8 iM io: 8 ~ =488l53 i= = = * Gompany Santized. Does notcontTSaCAiCEnI -- # I 2 :2 : :. shiscsdsiisiieaiizizaics oa 5841 | 1EE1R1E Pif:oi3oic:o3 3 gi op f#3e3r.d ofF rfis opdedr 1fdi Linh ii gif Slgpe 2g EE, sbii poiigiiigiiigitd of feid Biffre dics id zing 28. diez osadiddiiso sisis l 2 i ii ~~als sc-n hy. .- WsE on CompanySatan. Boss otainTSA Gl 3 z :si hefefefeilennifeieiets 3i ~~ 4d 31 11i1ii3 [1I 113 $: 3 EF OF i E Ei i 1IE0E:E E FF E 1QR ; IIE . 111 Bo sae fdada en Clg CeiirfpriedIerifiiigigaiiecgecidridicndgs . IiS , SIHEEETEETERRRRRSRHREREERE S R FEERRRRRRERD ol Pi:o: oo: ~~ os.. =. Ff 8 8 * === CompanSets. Ss rtmTSA ~ z Z3 sBie.ffefetetfeniietast 2 ~i : gd F 5 111 1 S 310: 1: [EEE ii gl. HHHH GHIE 1ii8 iife, iFFTIi.F dTisf. i i1ig dog fF orEiox oa al add os ad |2 Linn P0 oii3 iyii3die sgfi:isi iziaii3oiiaLiiEc] fiiisii3d9g3i5d3 Kk Psrsidygrsoeisgifagied SoM ~i i: i i. i FB BH ss ss iF sz [EP ---- ~ og 2: $8.8 28 E i EE ERE ER] --_ : I 3 33 iP iii g io, 1 13 3g oF 3 iid 3 fo2 2% d. i sirEiEtEiEcEiZe gBsl, dii:iliiiliisslilld g3ed if: 8 ZY ER & 2 cM H 28H% i: sos i= = = 5 . [A ---- ~ Zl sBfncainasdanalanndanal g Poff if ff fF id 3 FH Bod I Z a fry ry 2:5: 38 23s 2 ds: EE di: diy ii iE odiiodi: od f2 ile 2 Ble 23002 , 200,2 3 slit difgdirysieysiizdiigd 24 83r33253882i8GB85833828388 it is g g ~~ F ;. - = = . . Comper Sete, Soestsoma TSOAGSH ~~ 2 3 | l shsesisaaiaciaisnainnis i ~ 1 i4 14 i4 {4 {3 g Bl 3 23:z %ze:sz 3:32 3s2:2 Y&s2 Ss if oF gE38 fr3:8 ifrss P3p53s8 f3i3 | dF -3:3 Zr3o3a fT3a3u FZa z: fTaiaim 4 of o#s8: f2i8:: d8r:3rp ofdiyi: dliigfig J 3= dF F gidR 2iiga i2iigg liieii i2eidii .i20iie dga,d ffl ai P"d3aDiicieIiE diEiE tcR iiEgiRdE iliERoi] eiigEEdiiiaiiT aiEdlnEicgR 28, desifseilseiiiesifssil 3 ii 2 z 3 3 ~ 337 i. = = = = CompanySaiz. GossnotaniainTSOACo ~ =| z i g i ghia esaaiaiiaEaie i Pol if gd if i o1 if 15: pif gif ? EH ii $ 1g 5&3& 2T3g&:38 213:3&358 I1g4&3%8 Hof 3: 3: 4:58 44; ffl F03 f%r%3FosFgircoc fgtici:egf2 igig g d 1 pi aidl aicii iid 33 sHBd BE F3EId: FBiiolp:d Efprsiigl iBiilg p 423, P les3 i2i:b9e4 r4dvb78 aedi4l5i7oe8s4 d 34) HiHi gi g3 i7 EEHE - . - CompanySaiz. Does otcontainTSCACE! z g Ly! 3 ghfemasalalalelolalnis i fd Iiz EiEfE 1P1r0o1d0i101 1oq 3% ; i4 q:0E:Ei3Ri:Ed T pioz:ioiz i7i 1di 11a x: 1# : f::3, 4 40 01 10d PdoFes2i3t3tiinf nio: noi: nozin2 inoz in2 olad CaibiiiriiriRnEiRtEinRiEeRiEeRiEeRdE, 8of, PfeheBdriPiriiidebiibiiibiiiiniiiniiibiii ~ 2384 HE == x = ox = = CompanySos. SentconanT56A 81 ~g 3 2 8 g3 desssr2ig rl8 el2 ei8ed8sd8ind= nl.s%8 { f | Pili i ~ 1 2 .8 33 ' 3 OE Eo: i %1 i i fl, fan HHH gs ifo1 1111.1 ogi Pdi 858g, i + $%F #2 2 2 2 2 23 004 BT faiaigigigigigiaid Posh iE iE EiEiEiGiGd Cs iEIEREIEIEIEIEIEIEG . 3 EEiiiT iI EVYIRYIREELES 4 08 fff 8 8 8 ~ 33% i= ==x=x=== Company Sanized. Dosnotcontain TSCA Gl ~2 3 2 sitetletatetonds i --~ : dFBER7 1E1E1R3 i i: o, 8ffy 41 18.41 41}, | 38 2: 2a ad ]sfDoagpiiiifaidEsiiisiiisiiiniyc sp2 EIieCEIi ER& RI5 EA8 CE J Huibiinininh El, diliEbibaninaid fSM i:o3 33 3 . ~F o. LLL. Company Santana. DosntcontinTSGAGSI ~3 3z siisssfanceinsialnntial i . Posboiy sb gd idf :i yisis: ofia:s o$i5i8: z$i3:3 3 : dF iss ds: Piz di: i 2 Zzz Fiz gi Zig 2 oT f idzs: I1E3E%FEE EfEizRE FfRi:EI | i= g2 REg de-g 23Etei2 El, od2 JH8 EPliEdrdgiiriiiiligcdeiiiiiiigiiiiiiigiioggd Bl. dlasiirelidssiiiesiiid i is : 3 5 3 ~iF :: : CompanySits, Doctama TGAHI ~~ =| isdreedaedafonelinneinent ~ z ig iF 5 Fa Fl a i3 F3 3 xs8 $fcry 8 Ey3:9 Ey $839 PIpRy] : IPosis: disl odiiodis dfii: d I 3 zr fri fri iiiciii,t 4Bo:3 BciiidfiiiiediEtEiiiiidiiiiiiifiiiiiicied Cppiaiiiigdiiyiiigiicgi : J3H5, dFrdedisipsdrdiiisipeisdiilzaisdsciilieiscliy im cc 59 fr **: 8 8 8 8 [ES ------ ~3 3 i i: siresisilesiedsaiisiaecs : isd sd if iF oz: ori: Te: o1:i:ioi: ' 1g i 5 i: fz 23s fz I d9 o:s:8% dii:if.io dfid T1i: 11s3 3od p Pf lE d foyozg c gi P2Edi s P o2g3di d f3PdgD i d i4d SE. dseiise foiioss bios: lis : THE 3 3 : ol fe ~ %4[3 5s = : i 3 = * = Company Soc. 0s rtconTSaAGn1 rm El a 2 2 g F SLA EE R. eiE n TE niS os nieln i ~~ d 1Fo4: Tiif:o1o11o1o1d g: 3i 3iod: i353y %Fp EpE f2 i fEfi | o EE1Ef EIIEEE, I1E1EdE 107 5F,00ad8d ,0 d[iIlE"E:EeiP fiEil ErEREii iEriEnEg iEcEiiEig ReiEs . iSERIES, PiiiIdRaIsEIPEITEERSETETLONEE 24 ze 2 aol fs ~ EE s- . $e2 PF oF a 2 22 FoF OB === CompanySats. boo ota TSAG1 ~3 ghifeleleletetolelalats 2 ~ 1 4 I] 3 3 OF Oo: o%: oo: ot : 3 3 fF 0: 2 . 3 : 3 : i 5 i 2 2 2 2 & 2 & 2 2 2 4 gi, Bo: fF oz 2d 8pp3 3p%tr 3 r3 rFr i t of 22 2 2 2 2 2 2 IE PoH OPFiFEA EcEIEiR EIGoELE ELGS i. PETE EEEEEELGTD z iE #9 fc ~ 2{F3H7 F 8 zo: oz o oz ozo E85g55g LE ---- ~ oz g2 sifefeeteiefnniastiainls f ~ 1 if 3 g g1d 0:& f3F3 F3p3 iovd: oozi:d oozid: 3i:d | Po: oz i iz 7 83 zz 3 zy 3 23 3 3:7 Ey 23% FEI f N 8, T08Ei;Ei: iI:E i: |4 PE: oTp2 tHe24gIdr2Eds2 daH$g3IioM2g4iIg2y4HEi2gg J = ei ti i=F iinii rii3 gi3i7 giiFiEgly3 f+5l, FFPiivRgsdRpBgBrEsMrEgsdRiissdiiigaliiicig:d 3 ig: 8 3 3 2 0 8 ~ E57 5. FF g =xa = M = CompanySantee. BoetssatsanT5043 ~~ =| 3 siedesisddnnadisidsiast i ~ Fr ; fd i8 1:i 3:i 31:z 1:i 3 i is ic is is idf f5f 183 Iizs 3i iEy l2 11 1: i1:% i1;% ffrigi.figg 4f:s!4 Jog (51,58, (i387 ..%1,2 Bo:2 faE:"i233:5"f,392:89483 84i %428:1335 ol FLoriisiiiisiiEiddgriini Flip liiiaripaagsilc lg : 453, dI iirE iiEeER REiEdRR iEeRiEE iEiiR iiEiciEdER # i888 i il fi: : ~ &37 HE = = HE is == Company Satind. Bosno contain TSCA Ca ~~ 2 shssfas i ~~ If 3 4 fo: 1: df: 23 H1 i3 : 41:: 1 33 ozo.gfe3e. sfgdiy 1g, isi: HH ab ~~ 38 ico: os. % : [EE ---- ~3 3 z sffa2ssfasesniscairaaizac i 8 f fiz Zgz Fiz Zi: Zi: H4 of3odfiT&r: dtgasr dfiisi d1:i2sf d1i3:% IFa s2 ide ida 233 2iia 2its2 0t, of< $fdridrlodgiiidsipcisiiodgaigidiigcdeiitdgs : 33, dirriirriilezilasiiscd 4 3 g golf. : ~ ai i. . g g g ..s ... Company Satz. Gonotsconsan T5GA G81 ~~. 3 38%2zacf22aizsadalaaalianz i i $F fz 3 iz i: 8 3 Is: ss Ys 3ss Bas ' d5f dr$8s35 d$p8:3 d$s5s3 Eirsgd E3r3g ad fF zi: 2: 23: Fiz Pag H3 of3 ffrg:3 dfigpg fr8i3fo dfzi:g d1i4:% gfd f3 fg3E3zse_gfi33sE2g3i3i3Efe3iziggfi3d3 ofS| sfigtdEdgcigiiidgcdgiiidgiegiiidiigigiiiicy. 4, Firpiissiissiiissilbsst 24 2 ~ H%8H|% x .. .. Company Sartzed.DoesnoconTtSCiACnEI ~3 A 3 2 2 i . 08 Ts: fii iis 1: g IcEEizE FEET [eit iEiR 8 Poli FRE 003i: 3 Pag dlie Blin 0 5%of Ffiyi dPdf ofsirrd dffdopsf dPdPdE igsidf Hd, dibs iiiopzRlosisiss imR iicicd: 8 5 2g ~ Eos. . . . CompanySanized. DoesnocontTSaCAiCnt ~3 B) 3 3 sghEiz82 H isy eliieiyetoot.etas i ~ ig if % 4H Pos8 3 Eo iosds Eos i PF 2 Fo: o 3 Eg 2 & i i 4 368 Zz i 3 Te, $1311oz1o: iif bss iE G10 3 ] Tf3o 0h%aE;dEI2d3T3lT eidfnfiebiigi2gii2in:gesos gl Gl dPpslaiiieilrbaEe giBia iilstiisitrleiIaenHanIagEys . ~&F i. . . "Tr aa CompanySutcs.Sos etsoma TSOR OB ~ =| 2 ghefefefefiieteiiietete 5 ~ |i3 8 F 3E : E 8Eff 3FI 3 3FI 3 ' EI OS OS | 2 if Zz 3 s3 ob[ d |d4d gE dfzi ,, d EI ; : : 2 8 233i 2 HEE 2 2 1 0L3 hgighigingihjiabdsiifipgivhiidy 3 gEababitg. Bibi. Hitid iJfo, SirHeErEzRrereEislieEiRilTiia ea v0 eTO 23 = ea o 5 e g 238 8 3 IH g388 2 2 2 23 8 82 2 8 28 CompanySakis. oorotrin3AGo ~3 2 gEseier.dndsiR. ercer rdeneloi5n.gi8sgs i 1go:p 1&io%d3 p TFN rioI3 a3Is 3: ' B 131i di 1g,0PE1ofd 1o0 i: 0 iis 4 i 48 ; : 23 23% J J Tp RfIrEiRi gifil aggiai gisiitdn eiie HHER EARHIE HIELR ERHRERHERIRRRRR vil IEEE 88 3 ~dy oo 0D rE CompanySaniizd. Dnoot cosntin TSCA G1 ~ i3 i --~ 2 gZ 2 5z # 5 2 5 ; 35 8 31: fs 3: 3 1: 1: 1: $5 8 ii 3 OF Ex i oa F ro pl 7ESy i2y% i3 yf fl 23 i o@ iFsi 2% foidpr i: dPig I3 oIdf: Ig dTiig d ]i P3 oifrT.i%i3i.,i9e,t.i%3iEi2i; aisi;iaiiltsygg 3 ol RiPiPiEiiEih S iiEgiaiEgpil iEdgiiit 2gi3l, dfbrediiiidsisgiiieidsciiiisliiigsiiizfiiiiic ~3 i. -.. [---- :Z [EEEREEEEEEREEERER ERE 2 17 iii HE i FT 3 ~ i2 fo: i= 4= 3:1: i= 1:3 i. 3 Z gc T Ei Hoi 9 di 2 2 di itor diy 3285. % 254 = i| PCoraplprdaiiiailiiiibiiiigiieisiiiinde igle, iptiillesiliiaspiiieigaiitiiiisaiiiniyls Goi: g AEE oe oo - - Soniye, mm ~3 z5 . . i fd 3 1 zi: gf si: g8sd i IEEE EY Ti: iss pif gs 3d fry gg t 9 PF oz2cC giz Fg+ Fg3 J ocPooislii:s 35Bi3d 1 Eig;ir Polisi, gl tard diiHfiEidEs oeggdd 3JFFobqiiiirdidgegs EPirriidiiiiiisiiiiciiidl pf8 Ee, dPfiiosdhsdiisrliirdisiiiiiaieiiaicpledaliziliiaioqiciciisiiiig:d; 4% = 2 ~28lF 5. " x z . " CompanySantzed. Does ot contain TSCA GB ~ : gf. afecn.acdifafaniaing i BETTI HTH HE i if gi 3d 3: st it 3d 32 ~ 1 i i is vi: o3ic: 53 4 1: 3: 5 z F1:E iii gcc 2ii33 iZii3ii3: 4, iii. Ti 884d 5 i 83 Ziiigs [IE Pr: depgdf I50E 45 = 23 2 33 2 z2 gf| pRisEEE dicsbiRiisieigirsiiiiaigiignldg : A, feiissiiesiiiiiesilis: 3% #8 8 g l2 Z|oi.8 . FI . g 8 . : . . Company Sanized.Doesno conTtSaCAiCna ~ gl 3 $f8sdz2aslz2acorraiagiians i _ Posh gd iE LOESNH SNS EE dF gg 3: ogi: 335 53 yi: 1: ; i i fr: fx; i fi3i3f Iiis: E83 3 Pry iy 1233153 2134 i01 siligiz df fT iii; ier 0 Pf dogii; TeeFpiiiirriiiigidiiEediy inE iFii: ijEag +5 Eel, dIiE isReE iiEssERER REaREIiEE iiIRioEipEoO::S I IEEE 1 1 3 | ~gE TE : i CompanySaitzad. Dossnot ontain TSCA GBI ~4 i oldie : ~ gd 1 1: 3:if Pii:f 1 iiii 3 5 gs i 3 $d 383 88 i Ffg og 4 :3 sys fis oy fozy i fii Zg3 2 J3 oi03 if p dEiEigp dPiirg i 13: 1 f% f3 f 3 e ilog= ge;2 IY2; 2 IEE ET EN EE EN gf BH, dlr adiipssdiiiiiisisibiioidgiscl iif [EP ---- ~ =| :: sielfefesiifeiiTorgo.s ~ do:i 1: 1Fi 3: [1I 33 3 3: 3 i i ii i ii i dE of EdpE b ETER ab RIdTEid go: 28 2 28837 23 2 23% = iIRdIEJI if iaiE iEiIRaLiE IiEyiRsEE iEfEiRaEg 8ik , iHsEbEHisEHbRbIPiIHbCeIHsiaIEdIsHIiEHiRbIEiIsEisilgi:. Eh 53 io: 2 gz g g42d39 ~847 3 faz s.. 2 oz " FzE zz Bx "a " CompanySans.Goo otonan136A 81 ? i i -- 3 1: | : 1 11 i i Pd 2 t J: gg fg, EdFdf 1 afFd,ie Tg ai:de 11.4 giilgi 1 HHH R 25 RFE IlipEiHi iI fHeaHHilI eg Hiy 3% =FFdE Ti:S z S z e zz Crpei. cnn PBelatitatatat, 2 ~i & J1 [A 8 8882A :fi i7 3iI ii i|i : d Liiiiiiriiiaiiia ] gitieitinieiog : HOFPFP oifefi:fiesiii8ia:ii%ia8id:ia3idii.3ii3g3 i, HHH 23 Ei IYIEEIIEGE 5% Tf 3 sb Do. LLL, com ~~ 2] gz sFizasfasaisssnisaiaincs 8 2 i id 53 iz id id . dl 8 3i: 3:i: 3i: Bi: 3:: : A3] F Es3s3 di3:3 fs3:3 ffxdss d3a3g 8 fF Zig Iz Z33 {11 233 J 0i% jifg: BPriyg dlpg:: ditizi}, dlii:: J| 1= 2si2 le 2Blg e0 2 i, 3i02 g H, ofgp Efirgdleizfdgiistgiigddaisiifdiiioigidiigc 28, lsrriisridrriissiliaci 1 is 5 2 2 cab 1. : . . ~ a7 . . . Company Santas. BosnotcaTrSCAnGBI ~ isifssciscc.nsilesalacia Post osb sd 1 | ~ iff if 4% ii g J if i: 38s5:8 $38:8: Ifsss I$s8s8 ' iAF fs: : f: is f7 u f: i 3 dg 7 Zzz B83 Zz 18% fis 1:63; 33 fees Hof fs: fq: diid2 y dil, IJf J Fo3 gisFflc3fzrisedsf2ci3ii3asfsiiai3iiiyiizaEiidEfiiiariaeesiifeid3iii3nigdgig3 f-f$ EBHl, dIFisErdEsdicEfgsiEsiEiiRiiEriRsiEilNiiEasEigieEisEeiRsiEilTdd : af3 iig i8 Z8 i3 ~ 3oh87 I. .' 5 s Zslad d= a = * [EP ------ ~~ 2 j : sf Pos i ~ g 1: f1lo1g iff je: fis 3ieiisft , ; if fi: fog: [PEER Hg oii0; d1 s: dHEid HjiEg Poi geiiiitieii hen by g p Plp igar de id vio oi fihiiiR liiviag igie:i id 3B2, P[iSdEbEeEsRdElRoEesRdEiEiRfEiEiEeRcE: iEF: Jiah;ig g 8 ~&&83)7 i8.5 5 .3 .3 CompanySatced. Doesrotcon5tAiGnt ~2 3 2 g` g: ; shasBedisiisiEiascieide i ~ i go: 3 osi:i 3 osisf 3 osisf 2' 3 EI 5s ip 33 iy fF 84 ios: q 5 fs diig b di jHI 4 SPifig33p3 i8d3g3 i29n% 8 g4 54 ff Psihpii FREE oEcREgdRlirsianitz0g1goiggis fgsr di fig diiigiigt Bl, didi ss iiioss iiiioes ii oF I : [Er ---- ~3 g3 gFefefefalateietetilii, i 3 : T7 PPhirrid og | 33 O 3 3 3 3 3 iE 5 i: 3 iF EEE EEE EEN P18 dd 1d disc H2 2 2 2 2 2 3 3 228 32 il figfsigiaiaiigigdng, $ oF ppitibirbEiaesel FHL rl [EPEERRERERRRRR IRENE 8 : - i: ~#g E oEls.s 0ss00x Dx DxD s ]a .# Company Saiz. Doono contSGaAiGBnI ~4 : 3 silea iatetetfeteleteie i - 3] 1| d | Ez 3E3 E3 R3 E 31 E = i i z EF oz i % 1 P 3 1; i F10n 1 i:a1%l 1% }BozPoif iidlai oieaodss2f iddoaaoi stoatoaa, d IEE "eiiEiEiEiiEiEeiEEaRdiEeEiEaRiEaEgEeRiEe] [5LERESRiERfEiR iEiRiR iE liEeR RiInRR AEE ~ i28 $3e. PE s5 x 5% 58 x Cu ox CompanySantis. bostonT50AG81 ~3 z FEE i ~ 3 F1I 71 i 5; fd 3g 038 21011= 1di3:44 : IdfF ifrsiecdi,c SH JH Teilinge Fira: i, JPET 33 1i:i 2 33 2 8 ~8F a. - 5 ' : : GompanySanized. Doesmot onSaGAGnBI ~~ 2 32 silzsslsaddiaianidaienal i7 1 ~ Pii osdgd5e2Al i5Eefad dia f2 dEEir:3 :, ii F1 dfir:: fic fas IEE Ess je: 1 dgy i i F zy: zag 23g 233 2 dz Ti: fide. ii. iii i Ho ds: f::3f ff, ds: JJ F3 [fipifpiziiii cfgiziEidcLfiiigio J & edIEiEigEEiREiRiE EiEoEgEiEiE iE iE iE iE iE iE igdRE] i1l, ifiirdsdliigrisdiiiidsiesisiiiiiiciciiziicds if ii i g g g ~ aid3 i. . ) hl Company Saiizd. Goesno cata TSCACa ~1 gdrsadszaizaaisgalizsarca i ~~ fF z[ of| :4 o3E:li:so zii:z3 yi5i:i3 giZf5 z 2 : iz oj or8E8 o3r8s3 o$d8e5r fi3s3 fa3g Jf 3$33 Poi: 2l3gf3 dz: 3 ti3i di: SQ3i:3 dp: $i3i3d dp; og JZ o3= Fed2 de i2 ii2 anal, 2-3of ffiliiisdgidfdroieididideigililioigiiiigiogneg dl, dsedissidsriizeiizrati a: (IO GN CompanySantzed. GossrotconTtSCiACnBI ~ 3 3g| $5 g" sffasssesmifasisiiiicg : 2 igs HI it 3 33 a8: 33 f i;ozisi5 3 S8i3f3d 1$55:3 : dF PEE iii fey i3 040% 2B3E5: dBsgisef:oosq, ffii:i i1e1d, di i: itty, fi: F344 3 T- o2iI3 2RII daFage2 n 2fig2s pf Bf, fFFilgisefsgdiliilileeirldersirodaoeipsdgiiefiiigiiiiiecidsiif il : : ~ Hig . . CompanySanten. DosterTSCAGBI ~Z 3 2 i piediedatesiasieEelolet i TopviiiE ogiidf iEii E J1 f0 f1e8r% diedr: fpidrf 1i1ii8 58 z 313 313 2 11% Zz 32 d| fi fPg3:3 BBe8r8iof1i4:5 1101d1 d TeBoE fd fPdE oREpEEGiiooRi iEiGE oisirri ifii 5 SPPIEIEIGE III EE] $38 53 fizs Rios BERGEG SES ae . . ..o i ifs al res 8 ~ 3 gl RX E88 i FEE . Col. CopySet, Soret TINGE! ~z 8 Shel eat efetoatetetiot, I of, HHETERTLITTIIRRRHEHS Tdi or rrr a " q3 ii fies $ go: FF EF 2i .0%ydg i:08: 0&1 P ia i| P &a iEli1E & ii i, a +4 rT INE E SE ERIE Hf siigiadaivisiadieifsis ] IEE gett EEREEEEEEEEEEEEEEE : o3 FriiPePeBiiidaieiaing Ga8oM $f8o8s EyfF 8 EFBE BEE 5 Carp Soins, rtrn no ~ ; g je. d 2 d 2 d2n n=ld ltB.0Ee .R2I,l N0e8s0p %E,s { 3 - 1i i: i: 2. I doE : E ozoE : oro3 oEEzRI:E oi: ' | EE & 3 & 3 Ey g fF % : 3:7 z35 2y ig #F0p8f 0 0fd fdty g Fii:sisly f5dfF3 f2sipi2dE2digaii gei8igai2d3cifiilisiigiziiiqigiitffys of FLIERsEiRGEiRiRiEiRiEiEEEiRiEsErEiEliRiIiEig1; [2E5PR EFTELRIETRIRIiRR aRiRNdTeRRsE i808 8 i {FE hk [---------- ~ E ghisdiigaainidanninagnl i Phe, Bye Hag ld F2E 2 Tod is fl 3 Hof fs 8g 2 I3 z 1:i= 1i" 1 i; 3 gd ig gg iItq iFI i 2 B4F 2 dF 8% 5 iaagigsel : g3ii2 dirtitigas 7 fipiiiiiie ciiiiacbis l dE iggardisiegadid : 5 IEEERER E EER RRE REE ET 52 fieidiiddiebiatiiaiiid E2sl8 is 8 5 2 34 HH g g ~ 28l& i= - = Company Samized, Boosntconan T8GA Ct ~3 22 5 ~ sisafastaifiaindaninast i ~ P0F: fd P: es i: %; 1: : {: Psd Fs 1 ' IF: dr i: P11 iy s) fi Zz f3 f3ii iz 2 3 f1o%rd1s84 dBgpqi.Eg% A1g8;i; a1e4 i {-PINES iE eg2 dE e2idE EoE PrEfRE EeRteNiliR eEtSs2ed oo2 SE = rZiR gi r igdLeeiiF ySiTigYsgpdi3 egrd fBfl, dfsdbiizsisfaedsidiiiislaaiiciiiiiaciliilc #4 MeGW ~ 83 if g Dfzio8 go3 5. " g i i5 ii " " " CompanySites. Does otcomtainTSA Gol ~3 3 ghaeiete 3 --_ 3 i2qz4| 2 TiiPodd3 g1i o:32 iffdt ag .== ]2 58 i 1 51g Hii odf "sdgiifliitlie Nd g2 5 i, pili ~#E os... . # ' : : CompanySantcs. Doe rtconta0AiGon! 0H2-5D0a2y5:GavSaugbeehSrtoundiyc iTnoxRiactistywithOne-Generation Reproduction Evaluations -- Dupont-11418 --~ APPENDIX F INDIVIDUAL OPHTHALMOLOGY OBSERVATIONS BIE `Company Sanitized. Does not contain TSCA CBI 950..2D54a2y5G:aSvuabgeehSotnuidcy iTnoRxaicswithOne Genero ReproductiveEvslusions --_ a Sex Gro dniemt Observation tind cotusataolony casein Wo asso wo eobhaimlogical mommiesDetscted WT emus No obehatmological aorealisies Detected M1 sm NoOobehaimlogieat amormalivies tasted WT asi hoophehalmlosientamormaiies Detected WoT 650% Nooonmisplogscat mommies deste No3 Gms voopmmaimolopicel Nmermalities Detected WT esos vooobpimlogical mormaitiesDetected WoT 65M tocontmaslogical mermiiies Deected M1 esse Noonhatmlosient abmormalities ecectad WoT Gens mocpmmaimtosicnt mommiesDetscted WT 600 to cobmaimmtogical Nmermiities Dacecsed x sso to cobhaesiosiont Mmarmalisies Detected WT 651 voconthalmtogicalNmermaitiesDetected Wor asmon woopbehaimlosiontamemmiisiesDesssted ans woopbhaesiostont Mmamaticies Detected --_ NT G00 voopbthalmlogicel Nmermiities Detected Wr essont tooobbalmlostontMmommiiviesDetected Xx Gen nesine, erioadoegmeracion Focal, Right NT 6106 tooppehalmtogical Nmemaities Detected XT 665008 NoopbmieslopicatAmormalitiesDacected Dupone11418 oe o n 0 " o " o o o o " wo " o " wn o " ~ - CompanySantzed. DossnotconTtSaCAiGBnI aEsysvSioenyi Ttosi Or ooRepro ~~ fn SR --- sees many esis ------ xA Er Cn emai erin ns XX TTr rrimn measmoinnos: meomairitosesn P"E Ei we mmemm---- ------ -- X% rEr nCrmem cmmmmiearonn seesemte sess Pr" z.. ... :.. - ~ trestles Cons Sati. Onesotcnt TA 1 2e aE0sDys:ooSeySiynTohrisc iOnCp Grterte riss obteanaas mo -- ens i coin cons ww won 2 7 et eens a -- -. L3U7 otnn m em--i--so-- rte -- mes 23 em. me---------- .; ; vsivm wcommmoens--s--ii---- v7 on me------ .;; 2v27 vernn m--e v--wem------------------------ T --------nv-- .;; - ~ ere e-------- = ---------- CompanSrn. os triTA ot 9H0L.2D5a42y5G:avSaugbeehSrtoundyiciTnoRxaitcsitwyithOneGeneration Reproductive Evaluations --_ stay --- Individual ophenaleolosy Gbservations Sex Group Animl Observation NV 665160 No ophthalmological Amersalities Detected MOVIL GE509 No ophehaleslopical Abeormalicies Detected VE esos Ne ophenalmological Abnormalities Detected MOVIL 6107 vo ophehalmslopical Abnormalities Detected NVI Gesisz No Ophehalmlopical Nmormalities Detected VD 665120 No ophenalmlogical Abnormalities Detected MV Gi589 Ne ophehalsological Amormalities Detected NOVEL 66502 No ophehalmslopical Abnormalities Detocted MVD 665162 Ho ophhalmological Abnormalities Detected MoV 665027 vo ophthalmological Nmormalities Detected VID 65158 No ophthalmological Amorsalities Detected W VID 6a300z No ophehalmslopical Mormalities Detected MOVIL 665067 No ophthalmological Abnormalities Datectsd MVD 6055 No ophthalmological Amormalities Detected NID esol wo ohealmologicel Abmormalities Detected --_ NVI 665146 No opnehalsolopical Abnormalities Datectad VI ess02 wo ophenalmolopical Abnormalities Doteced MVD 685138 No ophenalmological Amommalities Detected MVD 6es112 No Ophthalmological Amorsalities Detected MOVIL 665007 No ophthalmological Amormalities Detected Dupont11418 oars @ " " o " " o o " o o o o o -- -_-- Company Sanitzed. Does not contain TSCA CBI 9102-5D4a2y5:GavSuabgcehvSotruidcyTionnRiactistywith OneGeneration Reproductive Evaluations --~ orfr: Inatvidial Ophehalaolory Observations Sex Grow Animal observation Pox Ges vo ophehalmologicel Abeormalicies Detected PI ess No ophehaimlopical Amorsaicies Detected PI asi No cphehalmelopical Amormalicies Detected FIL 6537 No ophehalselogical Amomalities Detected 7 Xr 665230 No ophehalsological Amommalities Detected PI 665225 No ophebalmological Neomalities Detected Boz esi No ophthalmological Amormalicies Detected x 65319 Ne ophehalmological Amormalities Detected Pox ges: vo oohehalsolopical Amomalities Detected Pox esse vo ophenalmological Amomalities Detected Pom ass00 No ophealmslegical Amomalities Detected PIT 665197 Retina, Retinal Degeneration Focal, Left PI 665236 Ne ophuhalmological Amommalities Detected PI esa Ne ophenalmological Amomalities Detected Pom ess vo ophthalmological Amommalities Detected ~~ Pom eae vo ophehalmlogical Abmormalicies Detected Pox 65260 ve ophehalmological Amorsalities Detected PI 665199 Ne ophehalmological Amommalities Detected PI 665206 No ophehalsological Amomalities Detected Fox ess wo ophchalmological Amomalities Detected Dupont11418 Daye o o o = o " o o o " " o o " o o --~ = --_-- `CompanySanitized.DoesnotcontTSaCAiCnBI 1902-5D4a2y5G:avSaugbechSrtoundiyciTnoRraitcistwyithOneGeneration Reproductive Evaluations -- eeSm. Sex Grow maimed PI 665306 FW esas PW Gs PI G6s1 PI Ges6 PW Ges PW Ges PI Gems PI GsiE2 PI Gee Individual Ophehalsotogy Observations Observation No Cphehalmolopical Asormaliciss Detected vo ophehalmlogical Amermalicies Detected No ophehaimlogical Amormaiicies Detected wo Ophthalmological Amormalities Detected No ophaalmological Amemmalities Detected No ophedalmological Aeermaliries Detected No Ophchalmiopical Amormalicies Detected wo Ophthalmological Amormalities Detected No ophehalmlogical Abmomalities Detected No Ophchelmological Aaormalities Detected DuPont 11418 oars " @ o " o o " " --~ --_ Te Company Sanitized. Donotecontsain TSCA C81 50H.2D5a0y25G:oSvuagbesSoundiyciTnoxRiactitywithOeGeneration Reproductive Evaatons --_ a Todividuat apbssaimotony Obmeracions Sex oro oient bservasion Pou Gm No Cobmissiopical Amormalisies Detected Pou cs wooobeaslmslosionl Abmormlities Detected Po mon woconenmlmclopicn)AbmormaliciesSetactad Pov 60 to cobsasteslosical Alsormlities Decected Pow cms woconsimelopical momalisies Dekectad ov cme wnoobshadmolopiont Amormalisies Duseccad Pow Gs vo cobsaatoslonienl smormlities Decected Pow cme woophebalmlosicnl Aormalities Decected PW G0 No cobubatmslogical Mmormlities Dcected Pou Gn to behaimstopicalMeomaities etected Dupo 11418 I. o o o o o o o o " ~ --_ --- =m Company Sanitzed. Does not contain TS0A Call ass: Shon Tey 90-Day Gavage Study in Rats withOne-GenerationReproductive Evaluations - a res is crn tens mimes ns +om MR ttnme mme-- imi termiois oot ---- + wn namm "dm memommmimioinet mamian ot mimi ion sont M ?+mn dwmn mmeommA imimeis svtinn oodt J> vRt Tn nwmm --e--ma--i m--i--n -- -- >Vmnn atan mmoimemnit wmivns oot 2 > wo > wx ame m mmwese-- --i--:----mom---------- ---- +> wwmr wn avomn wa eoem--i--t----o--v--e-- oot mois vot DuPont-11418 a:n .; .; .; ;; .; -; .; ;; ;; . ~ - EN T---- 142u50y5C. oSecoSnteyRTosit One GenRepro Evins ~= - NANCYpr M.rBReOR NvytB,]E5RDGAC:YO ei pr" rsmsoRsKTION: sHtoy p d d tespa Species:Rat ommTIAIMOp LOGICALi EATOa NSTVDANRY EG T B EA P EEa" e O"eEo--ths--i--mton ca i oSmempCS OmRnSOoS Nm 2s foeei n, ledsvEoBe 2rfft - loernddevsdfSoeorncds sgmna oa 12005 ~ - == CompanySntzed, Dee otonTa50An81 209H0:2-5DD4aa2yy5GG;aavvSaauggbeecShStvtouunddiyyciiTnnoRxRaiatctsistwywiitthhOOnnee-GGeenneerraattioonnRReepprroodduuccttiivvee EPvraalluuaattiioonnss --~ DuDPuPoonntt1114114188 --~ APPENDIX G INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH --~ -_-- Company Sanitized. Doesnotcontain TSCA CBI ~F so MIE mam mmmEm +5 Fi: momwn musa women 11: I GS 7R34e 3RMA%d3m 9039a 5388 Ra amsAE IIIAN } ~ ii & 570 ssnsensssn snsozonsss naosanssan ~ #0 F 333383358 Sddddsdid dddsddddad iHd H3IE 5CIEseEaEmReses E suoneR nsiny gsasssases 5E EiH F13R, S3uasmaessty f , mi ssen sred wgy |,gp sseadgnemienaan gd si i i S : 3? soneazsans j3ssgsrssse | gessenazss - 22 EiE 2 49) ~~ 34 8 Pk i 3 7Brasisas sansas snanasannasaes 3pea assn eanaas 5 g 3 #5 3333ssssaa 8 gasa3sasay oo s3sEsasncs i SBEEITLEET . IITRLLELEE . YeEEsEEEEe i i i Company Sanilized. Dossnotcontain TSCA Cal ~3 3 2 ff mmmy 2 PE1E5 seyssssngeeesm ~ i 1i1F7 mmm HEA 33 5i & a gl 0 er og HEINE Boe I i fifo Ed JB$ :p 3 qeap nsesens g i 4 i "23g0 esnans smsa ii g ~ Eg i . ? ] `Company Saniized. Does not contain TSCA CBI ~F _go FEENEET mmmmsmmmer aasmasnac: H P2P0: sseosemasmeessss msmmmsozsszeonnnens asssmsssemasssss 7 HEREIN EMILE Osa --_ iiig n 8 0 cogemesser ssssssssas ansaasence . f3gl f3 ogg:fF LIE T BoeEs3EnnI aumEINne pSImUGRNEE3MSAER saImaRensaesesms f i ~ Amaze : TRL z SEITE Jd li: { . 3 : 3 2 3 : 8 33 .4 gIoRnTsIpTeIsIaNsGeE | osEaNzEeAaRsNsAsNaTe p| sMssEcsR aseEsn - 5 id 3 El 3 Fosassssanss ssgmscenns o agassasasy 4 24 ~ gg i1 i; $g8g5g3s8z4z8a3c0a0s ;z FBEiRRJsEeER3aEnEaE 3, sggRmRbsuglaudsninyg CompanySanitized. DossnotcontTSaOAiCanl ~ 3 3 ~ go 2 5 2 8 g| 3 Ea I3P 3 --~ 54 8 2wy $ Pp5:0 Sm cSEhnIaemIgaaNnn 585 esssesmaes ei esadsdada Fief 3 j sessE nuzes: 8 og EEEnE FoR if :pg3 s sanasanens iF fg 73 ,% m 3553m5%3m68% i 8393849458 i i. - [A ---- ~i Fk g3 LE FBE2F5 <sSsaedmdedydessdssrs csossdseodsdedndesrs 1g ITM mah --_ ii Egd EE7 temmmsmns smsmsveewy E 3i H| I3 :wg vu SIIEIEERGE SAARC qt ; HJ opBpi, "eases i wamEn | ; HEE ; aIIEEEE | aEmEmEE i iS23E] 24 -- 5 8 fl: : 33ElJF 3g33%znamsIsngeensss i2T Rs3s3e9saIzseensiy 8 2 1 i4 HSEgEnUeEErRaEnEn0 ;i pQoagRneRilnleie CompanySanitized. Dossnot contain TSCA GB ~F E Tumnus amass PFooi: GamEammeEumneEsms mmum ssam nss oamssmasmisuenms 1Pa3 iPEE esis oi mens REESE ~ it37 I mmssananen ssassannas gessaedan qf & F cosisiisid ddsdidids dfs i i VHT nm mmm | EEN 4i ifFE3dg BEaaeenn 3i saamansnas : saamsntes RK 8 1F3yi Ssa9s3sSeIsn0s0s0s osesnsaensmsasusn 3 S ssoos nsee nas = ii B E 2i23 : i33 x71 a0s6a3e3n3a3v3a3s3y |4: SSd9eissdSd@dndidssy jsp AdIdAdSdRdIdLaNdLaEd ~ #42 1a , SGiEtRdassNeanRens GsEaEeEmRnRnRiGnEeR . nGRMiAEaAEEnHS 4 . Company Sanilzed. Donoscontsain TSCA CBI ~ # i Ons JE EPEiEa ome mm i: 155 sassmasE ~ is FE gl 15 53 gSaEnsEsgRssAan EE 4HIE: 3 ongnng Hoi, 23 227 5 aauuvsezssusaanmsees I 5 i & coscssssss 2 5 332 3 3 31 ~~ 33 28 sd &22 F2iP E I8 233 ii ! i + = gazozassss cocccssses 95333%RIE Seccescass sdsEaRdRsEaEgNeEsEdE 2i - [I S---- ~3 EI mmm mun Thr amamssm ssssesssss HER 1433: 5eo3sn3me3Ee3ss IyERCEIeCYTeRsEERn smsossmss SI9E3AARTSERtGEL:S Bl 1P70 ssaivesssdedodwsess dsdssdedsssesssdr EcngE ssenE ass : |Y iF.Eg vm-- mmm 3 mem 33 3 3 2 Hoit sessmeee AhAnddSnAne sess SennAAASeR 22583808 SdnArsAdnn FEL 3 i :2z:$ 4$8i%8f3 z35 mBsRsRsIsNoEeEaRsEsS i2 Usqmseamnsuans JE i sgn esnsa ggss . 3 i. ZT smssssssas :| 3RIssneRs g ssgssieRsy 523 FEpz orSdddcdns p dedsesnssd | AddddsHAnA 34 ~ 83 22 7 SSEIUSEET j BEImesEsEs gaamgsEsds i i 2 `CompanySanitized. Does notconTtSaCAiCnB ~ i 3Inmean FEC gsasemanez FE ig: shanEaEEm ~~ J +fT 8.5 zsasaszess F: f Ls ii i ie EETTEILEET] : Fofammma 8 fy 3 &% iY ~i FE assananes Ps IF.E aAnRssaszasssdiassty { Fi g i : Company Saiz. Dos rtcontTSaAiGn1 ~3 musa manus LE I? i2:0 333030g9s5a3s9a8y8 nAERmESIaRcIuEREsRsE 133 mums amu i: . ~~ z EL 5 1 i4 s3s5d3sRdIaWiIaIsLsT s GR4d U0BIa RIZ i HEE [I E0E1 Sgi weemen mmums i FI. i : i i i RganeNis : SISSIRIEIT 4 qt i oom mmm 3] i --_~ a3 i L GE33EE3EES i 2353333 ! 1 i2 i Besa i 2282382828 CompanySantis, Bos otsatanTSCA 9F-02-5D4a2y5:GavSaugbcehSrtoundiyc iTnoxRiactistywithOneGeneration Reproductive Evaluations --_ DuPont 11418 --_ APPENDIX H INDIVIDUAL SENSORY MOTOR FUNCTION OBSERVATIONS -- -- "= `CompanySanitized. Does notconTtSaCAiC8n1 H902-5D4a2y5;GaSvuabgeehvSotnuiycTionxRiactistywith OnGeenerationReproductive Evaluations DuPont-11418 ~~ INDIVIDUAL SENSORY MOTOR FUNCTION OBSERVATIONS EXPLANATORY NOTES `DDIVIDUAL smsORY Moron suCION scoRING svsTRY MRanPipuElati4o7ns00in:pen Field Areea (Fa ree-Reosming Space): 27 IiTeased reaction (sume sway or actecks) vortoRy szomLs: TD= nBCoouramsgaeplsecrtariteoeandctiroenact(ixoant E(lsiatncsheusreo,r flliipcsk)s ear) mars pov: "T1Z+2 nnGoiorlmiragelesrpao(tntesudemsrescpoownssred s(ivtoec)alizations, rapid turning) MPoUtPoTrLLAARcYivRiEtSPyONwSoEn:teors 9 presen oerscaTion Rarron: paebsecnt 0TI= apbrseesnetn --~ Te `CompanySanitized.Dossnot contTSaCAiCnBI ~ 3 2 3 : mom mmmoo-- P z o8 dES ~ lii | = i EHH gl 2 33 21E f Cd 8 gs zs EizH 5 EZ 3 ,& g sa E4 3ER 8 28 -com-o-o-o sooo cececccnos sossivassse . cccccccoces 2x ELIE ~ 983 32 28 2 2f2f g3y3E3i3s3g8e8s5s3s3 zz [EE `. - S---- ~ z: rt te i i F2I g i coo mmsoomn {fg d --~ : 3 cecescoses E . 81 i g ; 3] IE 3 gg: , F iB23EI EE cocecccees gg 2i:: ==F 9S > - 2 3 2g = 2 coccsscsoo EF ~8al 2 i2% s5ggggg8gss8gessss CompanySartzad. onsotcosntainTSCAGS! ~3 5Eoin P2 oE OR ~o~omo=-0== [:I i" i |JZ . g= HIE f cocccoocee gg fEg zzL, 2io2 8 id . i1%: ;gE 3o3F 33 g28 iHo.s ge Ei ~iMI. E2H%R ceccccccss . cecceccoee EgERggEsRanEnEsREs CompanySac. Docs etsatan SCAG1 ~ g3 in5f " 2g ee a. EE&I FE I[I E | 38 Hoif 2 22 oanommwseen ot cececocons HE 2 cocosssses FH HIE 2 - 4 EL. gd "8 H33S of232F 3 2 . $g8g ceccoooees 7 ad 3 ~ 8gS 33 i 2% gsagsgnzis 2a g 2 2 g 825 g 80 a , : : CompanySaiized. DooteconstainTSCA GBI ~ gEamonn g JL iPogz 2 o~=~0m~00=o i 8 32 cccccccocs ; g 32 54 ? Eig93f3 Zgz oeeeeeenees 1: : 82 ETEf cccocccces 2g i FT 3 g2 ececeocococococo ~3d ;i E2E%R zEsMgzzEgEsEase Company Santee.DosnotcontTSaOAiGnl ~ 5z . z St 3 ---------- !: : ; co-mmsoonn _ 2!s: o: 33FE] cecccncone J4 54 ai 42 feecococncs 1HI%E 2 2 411 232 3fzfa eceeemecee EE$: E z=5 . H Lif: og gEx8 cccecoces ~ 32i8g 2$ g2EE%f fs5gi5gs8zE5efgcEreiEnianizsss . 2% . : ee CompanySiz. Dos otssa TCA Ga ~F 2 g Eg Pi: Eg ok _ ig iom cecsccccas . Ef= 3 > 3g i3 EI oeecccnces z E EZ 2 3 ES ccccccccos $ : gE Bor B 3 s5 83 : HH ggEE CompanySac. Doss tsar TSA ~i 3 2g 5E| SS 5g 8 Z co-o-coo-~ P 3 z5 i i5 Zg 83% cocconccne . ~ Bo : EH " HI HiIE 3 5 ccoccsccoe 3 1 3 z : = 2% 7 $3 5 cococoooooo 3i 3=L3 EEH] . 3HT 28 ccccesccss gf gr i= ad 2 ~ &2 2 8 = F2s% sgespygEgagsgeagzesse z Gompany Saniized. Does nt contin TSCACBI ~ g3 5 ~ |] HE PEsES " g EE 2i i: 3 58 ii 3z 3 5 i, 2 2 2 4 .. 4I1:F= i4 M gi5l F2o g =% 53 S g 22 ~ 8a423g48 g 3 3EL0I2E Z8l 2 Zz --oco---o-= "eoo-~co=o ssssssssss . sosssssess -gEiEgEigHgsEBaHEsEE: ::. - Z1 :? I3i5 z GompanySanized. Does ot contain TSCA GBI ~F 5 3 . E Io: I] g ~ |3 38 ceccoccons g= i i: | ibd i z z 7 EL, i 5 ff i5 532 .g2: gg s8 coccccocan cooe cosess Ho: iq #9] 3 --~ 24 8 32 of 2% sssgzssass z2z3 338ggiges CompanySantos. DossotonanTSCAG1 ~3 EE:g 8 i5 z ~ : i 33 Z 4 iF E3I 3 23] 23 : g : gz 3ET5Z covoconcns EH 2 3 2 : i cococococococoo " R . 3 ~ #3 i 2f sEszssgsas gz 383888 [EP ---- ~3 533 5 fF oe-meomonnn g 11d 2 E Pf 5 OE eels 2 8 4 ~ ccocococccoo 2 i3 = 32 gi o:3 3 ccceccesss : 1g5E 2gE,52 coccccccoo & TE SE g3 3A z :25 . . 32 s3 5 3 FR ccoccocooo 2z%g &3 ~ 33 i gs ddgddgyee CompanySanilized. Docs not conTtSaCAiGnBI ~F 2: 5|E g ; fd I 2: gE Boz g z emscona- i= 4gf 4:2 g i3 2 ES cocosccccoe 43 5z:g 8 . 25 3 2 3% ie gd 3 ~ &3 i FEREEY EETEYES: iz ggggggegge Company Saad.DosrtcontTSaGAiGnE! i I i TOE. 8 2 o-o--oc-o-o g 3 zE 5 i& 8g % ~ i3 izg cccccssccs I2t i HEH Z i, F ii: =13 :: 5R us R 3 $ 25 if : 5f F 49] E]g ~ 33 Z < svesseneee 52: % fsfagnhsagEzaaRzsaes i ggygsgiges GompanySaitzsd, Doss otcontSaGAiGBnI ~~ 3 . 23 g -- 1 13 3i 2 i" , loi: EE 2] |z 2% 3 FE. 2il f ~:agl 3 iHf] i ccccscccos :f ceoocons i. - & cesscsscon = 2 $ ssseensues E 2f E2sE=zsEsgEsgEs , 2 : CompanySaiz. DoesrotcatainTSGAGl ~F g2 g: [BS Ez 2 ji, ~ i: 3%8 cecococcns &w g= 53 3: il 2 B EE coccoconos 3 PO : o3 is5 E23 ee sssocss g3 &OR F . Ho: cf 22% 3s 838s coccccccocoo : sil: HE ~32M3 I.i i 2i8 g gsa6zg5s8a3s8z8s4g24s8s [TT ------ ~ 3 EgF ommmemmmmm E; 08 FgE cena. if gE 8 a Z --~ % zg is sceccscscs &3 of 2 5% HIE i i : 273 853 51 24 ~ i33g =8 2 = F% 3E0BxE5 ceceocees 3 E 25 . 8?2 2 E2ESs coccsscoos =3 2 z 32 28 sezgaaggss i Fz g9gEggyEEy 2z [TT ---- 22 3Enos & . 5 8 & ff 5 --~ 5 Fi i E3l2 eoooooos i 4 25z:2g 3 H: z Z... eonconese 8 I 2 9 | g 2 iafg ~ 388 a3) 2 28 2 8 zz cocoscooes : 2g3g45u88g58s83g8 83e88e83d48y88 & . t:i :z2 3 Company Saad. Docs rtcontainTSGAGE! ~3 a g8 g Comm moo ~~~ zg ommo-0o mmm 2 " i us . i2 32 5E i 48 8 8HIE z i I 8 2 E 3 i OE gsF 2 8< 8 22 g EH 3 3 2 gf 2 2% coccsccscs sesso ten . oococcoococooco sapengaass CompanySantzed, Docsno contain TOA GBI ~3 2z 2Eoaimennneo bE EEEg : 2 I cevommmmss 3S 2 za _ i isE cecoecsess ii3 :33 g assonsnnce i,1<5 : 13 rEos2 :: Ei cco~cococos |osi! 3 g Hoe FF 3 3 A 28 ccccccccos Bo " ~ &#4 5i ELEE8Eg3gEgEegRgEs 8, I13 1] iid CompanySaritized. Doss not contain TSCA Gl H25425: Subchronic Toxicity 0-Day Gavage Study in Rats with One-Generaiion Reproductive Evaluations --~ DuPont-11418 --_ APPENDIX I INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENT i -- CompanySanitized.Doesnot conTtSaCAiCnBI H25425; Subchronic Toxicity 90-Day Gavage Study in Rats withOneGenerationReproductive Evaluations DuPont-11418 ~~ Individual Notor Activity: Duration of Movement (sec) ANnamtbza) 1 2 Successiv3e 10-inute Intervalss 5 mom Hale, Grow - 0 sarko/day - BASELINE sssssssooons a sos s wm sme asmt, 8s; 21i 20` 7anm22 GSG6aesss0oa5sa8st 33378 m =i owasm anowa is [F1II 34 ssSeeesaisonsn Wm 3s dmaaee 1@5% i31 1i0 Pt3i o78e0s peed a daw 5 S EN] Male, Grow III - 10 mg/kg/day - BASELINE asfSeisiszaoess 8 Br s a Eam a3s2 1 : EH5 513 aiasa sf6ae3ss00o8sn aw deno omB sa em mIn a51 ns1` oFa2 ERei]no sSSeeeasnrtso 8 s Be B ami aa3a a2m%: ai3 FiP I m76 pH eo dn i 57 5 us Male, Group V - 100 mg/kg/day - BASELINE fdaseesssaoaossns 3a5 S Bmm m as mam asi3 1$ i85 1278235650 ~ Spseestail0]ss 33ia8 a1s a5 aS0 as5o 3o 1H Yu]5n50 ssseessay iB 5s5 mai es ]aamm a&2 aa13 i2suan55m5 ans 0 me Bm ak am am Male, Group VEX - 1000 ma/ka/dny - BASSLINE prsSe6ss007 m F Br oE ahm ome am aa&ma 153 oFI annw apSeessta0es]rs 8WGsp ooodmse os3o aia1 us3i 03 Poanmn Gsseeessrsiasse as0a0c eamFoE 5 ds i am i1 a072 Bw7mn% py @0 we s 1 CH ~ 761 `Company Sanitized. Does notcontain TSCA CBI H25425; Subchronic Toxicity `90-Day Gavage Study in Rats with OneGeneration Reproductive Evaluations DuPont11418 --_ Individual Kotor Activity: Duration of Movement (sec) jsnoimeals : 2 Successiv3e 10-Minutie Intervals3 6 roma Male, Grow I - 0 mg/kg/day - Wook 13 seSssess00o0a8 @ssi a 3oom malee amm me maawee uFBsEne 1m ue pEeseessooess B3$o6 owmehs Gmoeem oaimene 3 6oEoR baaa prsseeesstiedds d w #6 o ow m0 vm ase maams maFwT wBso oi1sne sess mom om Ge i EI Male, Group III - 10 m/ka/day - Week 13 psGeirisso)s iw 5a50 ospmoE aa1mmme daaess i1omuse ws Fe Hn ) ase prsse6essootrsc0 3io 5 onaSse aaB0so w3mes0 oianmmo ow6sse m16ms sgGeosssioaso i@$00 swss od3ms 3pamme BHaeyo aaamsm addeomms pie Pe Ww wm om FH Hale, Grow V - 100 mg/kg/day - Week 13 --~ sssessooxsse seson 3 m 3 aM mde Woowmae mdaesms dmass aaasmms suameeo seSg6ea3st01ss mm ooo dmoom waHmse aaaeme aiamae Wiomre ldaoemso pgSieesars Gwmiso dosa doBemeee dwIsm 3doem aB%mb aisipo peed #0 Wm 8 Wm ms Male, Group VII - 1000 mg/kg/day - Wek 13 psseessdoo0n2 amime e owws aa3mm oaawmm oaaae0 6aFE ass am SdSee5ss0no5erz H&eo osGesms asmeae oadmms aahmo EBaIs a ne fprreeeesetiredd]s Wswosoo oodmr adWnem m wame mBa oasF Qo r wdms sist Woo Em Se Ms a amo aso --~ BCH `Company Sanitized. Does not contain TSCA CBI H25425; Subchronic Toxicity 90-Day Gavage Study in Rats with One-GenerationReproductive Evaluations Dupont 11418 --_ Individual Motor Activity: Duration of ovement (sec) snsbnaelr 1 2 Succa3ssive 10-M"inste Inteirvals 6 rom Male, Group I - mg/kg/day - Recovery ssseesssso0asinsae w20s oddmma aadmes oEimr 3 5 um5so olaeos pprsierssoess aa3em5 amee 2aB5ev1 s 1aa imws oa1ma5 dbnaaem drSesrsaa0)as B aee mm sss aafmmme aoams m aosm mahms osnewem feiss 3 ds me 1m dm da 06 Male, Group VII - 1000 ng/kg/day - Recovery dSseesssseaoaonr2 apsemed mSoemo baamomo 1ass0s a15 wFn mE bum Spsasosoosdesr ddoso SBS ee dwowms 3awssm Smow0os daaamm daaaem seSseenasnsa e BM ao oommadm p0e asaswe ome53 ai5mm ia isnee sense Ss 0 des Hoos un --_ --_ 6 Company Sanitized.DoesnotconTtSaCAiCBnI H25425; Subchroni Toxicity 90-Day Gavage Study in Rats with OnGeeneration Reproductive Evaluations Dupont 11418 --~ Indivieual Notor Activity: Duration of ovement. (sec) iAibnea 1 2 Succe3ssive 10-i:nute Inte<rvals sem Female, Group II - 0 mg/kg/day - BASELINE ssaeesssiiaaoorl ww 351 soem oow2me iosmo Ee8ous5saim3e08 dssesssiais @3n5 dS5as00 idnea 5 aafni] wwm5 ie bae safeeestsazrre2es3 as e moaam 0aanm 3s 58 aswdse ao m0 an misme sess #0 we om om 6 ae om Female, Grow IV - 10 mg/kg/day - BASELINE esaesnaarnss soseese Sammso 1dai2se mw 1s ia7m B wmo e u3e56 ssSeeesssaasos si woo mos5e aa1mw oamise aoa5mn a20%o aaEbYe SSSeosssaaa0n8 83o1s maiosm oaomz par6o fis7 i0loTowm5n07 asa 3 is 7m ae ims Female, Group VI - 100 ea/kp/day - BASELINE, -- Ssseeesi1az7se0 ese sn mddsa eaafsa aaaeees 1ma01m aTso0 a bdeo pSdreesse2i3s]0 ds wes e3sm a oaDwaoe aaEd BBs3 omim2 dibmmm G6ee55s32z00a0s iiaon ai25m w20mi7 FEoi ov 3 isiaS52s0 fsa wm 3m som FH Female, Grow VIII - 1000 so/ko/day - BASELINE sssssssa2a03 3Ew5As owwse am5mes ooam1 z1i o15 aa7mm6 Ssdsesasaeins 3 do smHie oanmmEs d32so dE 2m0 I m8s ] 0 ie pspreisinnds wa wso oeoasm dEBemm o5aw% w 3] aaam asee geass of 520 som om Im iE PP. Ter CompanySanitized. Doesnot contain TSCA CBI H:25425: Subchronic Toxicty 0-Day Gavage StudyinRats with One-GenerationReproductive Evaluations DuPont11418 --~ Individual Motor Activity: Duration of Novasent. (sec) fNraeber i 2 Succasssive 10-K:inute Inte:rvals 5 mem Female, Group IX = 0 sa/ka/day - eek 13 peEsidsse g nwos mowmm d oBme ssaem aa2m m S5o am s5e5o5 sdseeesssazinsses 3d Sa wS aa smionaams aw amo aaw dasmme psSreassr]a2s Gw Wo yommsom aaasnw a3l5e Wiwmoo @memso awnw a wos an 3 wo Bh Female, Group IV - 10 mg/kg/day - eek 13 dsGesseesnaise prapesdt wsoe addmm edw0 ahmes am Iom m mbsm pSdreessta]ass a3k5d6 Bswss omam3o8 aam iass;m a3Fwm I]dmans SSseeosssaa0na8 da0e aaSn amaSimaan s0e afam os dBmwwe pH Wom 5 ] mom ae Female, Grow VI - 100 sa/kgsday - Week 13 -- fessissirs0 fase d s 21 uo s3m aomm me 3d 0 sam ms om doommm edaewww sSesoesasaanz0 d Bomea asde Bamess aiaenm w6So amdmeo maameo SGe5e5s02aao00s 5m 31 owM3m% dmee dEomoAe adss ma5se mdaepn asa wm om Wom wm Bo Female, Group VEE - 1000 mg/kg/day - Week 13 fiseesss7az30n aiwas aosweas awdssa asamem 0adme am aw awinmm seGpessaaisns wo oo00wSmm ionawm aammn oms35smadm llnmna pGr6s5a3a0s3 iwomoodm daimsm so0 wms mom 3F m 6 rm ]Dow pi SB mem ne ae We --~ 76s Company Sanitized. Donotecontsain TSCA C81 0B2-5D4a2y5;GavSaugbcehSrtoundiyciTnoRxaitcistywith One-Generation Reproductive Evaluations DuPont-11418 --~ Individual Motor Activity: Duration of Movement (sec) RoAnmipzearl i 2 Succe$ssive 10-M"inute Inte5rvals 6 mem Female, Grow II - 0 mg/kg/day - Recovery ss6es5s11aa9n97n WI mo o os mhs oaem weiam o 21 omi1m9 uaeemm paSrsess2zeas PS39e6 mkhses lsaamm ihaae ooFamC aaa a7e61 sesG6easa2nr6s0 H 2i%n eaB Bas ra awamee dm5wr oa1ms iu5ym1 ssn G0 se me om a a ai Pesala, Group VIIX - 1000 mo/kg/day - Recovery sSsessasrza00 aWaBals @a3es; oaamme m awmo mlBmm 1ilesem fSSeeeaszsaemse o w Bi om mdw admoe aE3 mm mIim ump2 ooi1so0e% seaSsexss2ia9ss9 W52w0 dbdeee aaahns P H4] om mBoa0m8 1n50n813 is Bom i. 0 wa ae --_ 766 `Company Sanitized. Does not contain TSCA CBI 25425; Subchroic Toxicity 0-Day Gavage Study in Rats withOneGeneration Reproductive Evaluations --~ DuPont 11418 --~ APPENDIX J INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS -- =a Company Sanitized. Does not contain TSCA CBI 9H0L2-5D4a2y5:GavSaugbcehSrtoundiyc iTnoxRiactistywithOneGenerationReproductive Evaluations DuPont 11418 -- Individual Notor Activity: umber of ovements Ssoamtboearl i 2 Successiv5e 10-inut:e Intervals: 6 rom Male, Group I - 0 mg/kg/day + BASELINE sSdesstsoooos m Beoamamman710 15H uis 5 sFE aas eGfeesssooomanst w im0 inHMoe a aS e me u0 537 F5iR a7b easeaseino6 1m33o3 1o136s7 53i] $is i12 g:5 s33a58z08 peed ode as A ue Male, Group TII - 10 sa/ka/day - BASELINE sSseisizsae:s m o us a om meo o5w5 97%2 352. s56 i2e0 dge8ss3oo0sn6s 1Hf0oo8 1f8i4o 1aass ais3 as15 5273 5aS21r6 sefe6ss0a8hz0 mBWos odeifino aa5ms ak7e3 ov35 53i i3a0s aa Ww ae ae LI. Male, Group V - 100 ma/ka/day - BASELINE --_ sSSseassooaassss mmwme s1s2a2 sm5 82H ui3 u [ 7a a a pSseerssai]nosy n Bs omuoues oiw3 aonn1 3:5 7 :Eoah fSsaeeiasns Firs ouwe 1oau]ms o25w 1263s 32rR 56 ans mo mom 15 2 ns Male, Group VII - 1000 mg/kg/day - BASELINE sdSssasssoaao02r ww Boe oeu 1a swak 1sis 533 u E[R 1w] pSEssooos]s e1Hi2od d5 eanas1 523 1: 31 iai55 sfSeiainas m 5o 0w mus aaa5 1383 B1ii wo:3 2 sess mom 3 a 1 PB --~ BCH `Company Sanitzed. Does notcontain TSCA Cal 9F-02-5D4a2y5:GavSaugbcehSrtoundiyciTnoxRiactistwyithOneGeneration Reproductive Evalustions DuPont11418 ~ Individual Notor Activity: Naber of Movements suamnbear 1 2 Succa3ssive 10-M`inute InteTrvals sem Mada, Group I - 0 mg/kg/day - Weok 13 sseesssoooss wm ooe amoawn aa5am% 1a5ms waass3s aw13 aaSo66n1 SsSeeassoosssats ek142td #n0 aedGme uonai uamn s ha2b asiose feeetaseiieos f W 5 o efm aei au5s2 smarmr 1a31 sia a34 seis Bs de dm 1s am EH Male, Group ITI - 10 ma/ka/day - Wook 13 Gsaesisisoosnsys m2io 1Lm3e00 wa5ee 1i10e: a57ns 35&6 7E7aH6 sseessshooensoe f jHes emas s mame awaamani23m 31u%5z ji7m95 sSSeo3an0ia0 1Bw1s2 owaimmo oaonmse a1B .s sdasm ad3ns 7o72m8 ne i Be as Ba sas Male, Group V - 100 za/kasday - eek 13 spcsesseoosns w i mam w e omHmeee asamomoa i1s1 1152529 77m56 ~ sespsreisis00esy]s b2irisd au13ae0 ao5em anwns anmo aawm oma cdseisseiiss mi moo maw a ano aaoans; s 11825 a1e359 7S34%08 sass a wom an i 1 EH Male, Group VEX - 1000 ra/xa/day - eek 13 aGSssesooonnt) ii us admeammsas daodwe Hmas aos em maa Spseess=oasesr 13tHi6ee w oHm au m0 1n 17a5 amB FE dri w5m% ercehnei) io Bn o sm aFrie w 63 a1BG ady m0 waim reed wooo ue aa ie 5 wr Ton Company Sanitized. Donotecontsain TSCA CBI H25425; Subchronic Toxicity 50-Day Gavage Study in Rts withOGneneration Reproductive Evaluations Dupont-11418 ~ Individusl Motor Activity: Number of Movements jAneimal 1 2 Succe5ssive 10f-linuce Intesrvals 6 mom Male, Group I - 0 ma/ka/day - Recovery ciGae6sss00oaasss F152r8 we ao ns 1H10e56 i1m0nm8 11558%s 3si5e GSGeeeststo0o6e W mfoe a oaBi aa5we ia7s aa1 a57m%8 aairsl SGSeansaaosn 1ww2e0 omBonss ae onme a1m5505 EiB ose as7a sia mom H i 5 ns a Male, Group VIE - 1000 mg/kg/day - Recovery sss6ssss0oo0nn7a m m is o om mimam3e0 a5F a E ia5 n 2 eaE GSe3a300o8n7 w1B0eo oidam oma uss a oaan F 1m0 E1d3eSR 0a11 gasoesaitnane i @ Lldosae aom5ne au5ne 1a3e2 7n5% oo@8am seis Ho dod fs as a --~ -- `Company Sanitized. Doesnot contain TSCA CBI H25425; Subchronic Tonicity 90.Day Gavage StudyinRatswithOGneeneration Reproductive Evaluations DuPont 11418 ' Individual Notor Activity: Wsber of Movements sRnoimnpear1 1 2 SuccoSssive 10-K`inute InteSrvals 6 rom Pesala, Grow TX - ma/ko/da-y BASELINE pssreesseai0sd1s ou0te FamEms aob 133o 3a1 0ss is$0 pprGreaisaesds isiios isie] deo w 35 wEI: a 1 paEi0nt pGSaeassaze n H1s aumaow wie aoewas am13 oaw3 omFSiis as mo wow ai as Female, Grow IV - 10 mo/ka/day - BASELINE sGdesssasztass 12w1%6o owie omw1e6 m7Hl omB3i a10e5oa1a7 eGpessarsae 112H38 owB5e auEms] owmire aw1Bee oFar3 oEmd Sparnsaaesde Bine easa5a oBme3 110s8o 1i: oxf` aE0%d ea ws wm @ Boal dW Fesale, Group VE - 100 mg/kg/day - BASELINE ~~ sasesoaissao 1Hw2m elsowm omHosm oaommm oamn7 w5s2 a7om%m pSSreeseaas]n0 1m 1s oaB5 oomadneo om 3 owmmi aomm +aa]z SSSee5ns3az0a0s im se eaize oam: iii 2%33 n i m36 pit fam me ow ow ee Female, Group VIII - 1000 g/ka/day - BASELENE SsSesessi2aa30070 m1i5s9 adw se w& 113676 31 :53aSaes pdrresyi]s BB ise dedBsr aam6ee oao5w aIw be 2samas How p6fr5a3s0e0 12m H7soooon12emo1o256 ifost 2pir] a 25 m500 pd moa 5 1 som ow ~~ - Company Sanitized. Doesnotcontain TSCA CBI 'H9205-D4a2y5;GavSaubgcehSrtoundiyc TinoxRiacistywith One-GenerationReproductive Evaluations Dupont.11418 ~ Shdividual Noto Activity: Number of Novesents RoAribrear} : 2 Succo>ssive 10-Minute Inte:rvals 6 em Female, Grow II - 0 za/ka/day - eek 13 pasreessez1toeyr9 i112 1m06e bm&ss 1a0s] an2sem w5B r mo7m6 sSseesssaiisaes im 1s0e oaoiuei oa7e% aod5he iwo om13F6E a 0 edsesssssazaar0e 1mre i Bs BMse4 aB ass amaiss iaimn 781 pt] #0w wis meh Feral, Grow IV - 10 mg/kg/day - Wook 13 afgseessszaates 1mn7oe moowwoss oomum0s i aomw bi15n fi0sn o2sm5se psSeesseaaasdns m imzoaoiuie il7ne% a1@ns iaGmm B52e oTsiewe Ssseeossszsnoa)s H a imakmA ao5sa am a i12s aBaip s05h fsa mo aa 7 BIE fi is Penal, Group VI - 100 mg/kg/day - Week 13 ~ ssest#i1 wi9o6 oma 10wom0oe oaw pme mo3 m 1I0mE5 7as6e0 Gesz30 wo eam in no ow psrGeessizsisr Em ie awim o waamm oa5f0 ao5bm 3m ER a eSp6s5e3a0t0 ww Heoo asoomme dl2ee u1me ommmo as aomn sas5%z Fesale, Group VIII - 1000 ma/ka/day - eck 13 segsstessa2i0s9 gesans Hw6eoosmasms aao;mm Eaas)e waaso au5m saa75s Hoa ns a ds om Scieasssiiisso Mie aiasm mans doawmgs nn a FBsAes Tio se esgeeanssss 10he2l oiBie ouumsal imss oneoism ad2mm 1768 --~ Tne Company Sanitized. Doesnotcontain TSCA CBI H25425; Subehvonic Toxicity 2900--DDaayyGGaavvaaggeeSSttauddyyiinnRRaattsswwiitthhOOnnee GGeenneerraattiioonnRReepprroodduuccttiivvee BEuvaalluuaattiioonnss DDuuPPoonntt1111441188 ~ Individual Notor Activity: Number of Movements Nsnetpnearr 1 2 Succa>ssive 10-itnute Intesrvals 5 mom Pasale, Group II - 0 na/kalday - Recovery sSseessssa1in00n79 imwsmt oms8ome aw0ass 5a%w ps1od8a 5% a&580 sdperoesazsss w wa or uonsan faow 8 aBwe oosS$smabe pfieeisaees 6iige BuBses oaBmaoe aaamns 10aB0ms datoll a6fi0e sess Wooodm i i ma ai Female, Group VIZ - 1000 ma/ka/day - Recovery sssesesssi2zz0sy9 wmHso om1wam m aiwh awuis iF1sr0 S sE mi Spseesseaats m wio agolem 1Boma onsu5a ai16ns7 a%ne aea GaGeesssszao5z mFBEeo am +1a1m 1s 22 as25 wa2om osommm sais wom a fr dom Wm --~ --_ -_-- EC `Company Sanitized. Does not contain TSCA CBI BL25425: Subchvonic Toxicity 0-Day Gavage Study in Rats withOne-GenerationReproductive Evaluations ~ Dupont-11418 APPENDIX K -- INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA -- -- TT -------------- Company Sanitized. Does notcontainTSCA CBI 52G R 000aGrogeT Ssr yin ats the OOrt Gn n ReeseEs vins on pouwrnis rm INDIVIDUALANIMAL CLINICAL PATHOLOGY DATA c-- onBp ne -- mm EXPLANATORY NOTES &EgE 5EaCEEEE mEEeLeEe EReEl i 3c ERED tig tT=Es sE oA tm Eo isnae GE Ew E F nE E EREa y aEE rEE rEmNR E EESe.l ~ = 3Co S H REEEmEe y E SEae T niiEEn tse us erin ne T 5 CEE EE E woB ESeCapEia Et: igEig ? tReEE PiEe co.matneo ssorseseteenint cmt ction E 3SI ETCC DCEESRhe: iwhnehnseoloond cocelle: : 3: EERE mam cn eet is sete ction --~ EE PP ---- 9H02-5D4a2y5G:aSvuabgeehrSotnuidcy iTnosRiactistwyith OnGeeneration Reproducive Ealusions DuPont 11418 ~ INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA smpvaTIon: (contimed) EXPLANATORY NOTES (Continued) masviEFouiEal caonglutPaltaeionHnvoatautnens aHePEr D1 LbDreaoitmvhastvoenidsionpaerHtiimael thresboplastin time EdiviSStiuirad CDliensiecnar) CfCheaaammtspsterry vaiues: arUArTTCD1 aa isopraabritinaanteSsoirGe neonrvtaerrasegneesnsteesrase maBrNCC trCreraaeenBictrhhepeni EGme6D gCErlholtreeseiteirteshe cAt7ps C0 asSitotbeihiirnoan =-- --~ aWXDCEpsoa otedst " BFPCIITB C-Fi ppplllaaasssmmmaaa Glam hsHpceuefmenoormltiuyadsseisffrroofnmrobLmliooboolddooadsamsspeallmeepleffoosrforFFlliuEoslriuiiocirnsideSeerradeeitmeeirrnmmaiicnniaaott?iion masviQtuAal O=eicnuaallysiitay v(eotdutestsies color) wcWaiL 1 1 vSCeohiahnlaeosmolatiey Pi WTED rtthienyel,oimiarriutsioiaof the zeciprocal of the hydrogen son concentration - w[WisCEEuxro]innietidnoogeenr wre Urine preven . natvimwdaurenl DeinCeeitnWeiheearotratceospoeisn,sdancianritteion values: - HBNRCEE C nRUrroiornomeragTacenrdyiaBstlaaostsee celts Sm Facial observations --_ ~ me CompanySanitized. Does notcontainTSCA OB --_-- 9F-02.5D4s2y5G;avSaugbcehSronitciTnuoRniacdsitwyiythOne-GenerationReproductive Evaluations Dupont 11418 ~ INDIVIDUALANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES (Continued) hen iandviovnidsu.alaal]nimoaflwdhaitcah aarxee neoxtplasienpoerdteidn, thiet msatyudbyerdecuosrdtso:one of the following reasons of STthhheeaeirassewprapsSli.eeinvwhtaaesssutccntoolituocltidtesenudtimtoats(balmpoeeprl)esfvoerfaoircneetsdec.sito(igRnWg) (iS) ShesSaEatAvHasieavDairloarbletofosratiesstcionglle(cStRi)on hen BOE FaonxianEndyiviCEdaulacluclooabetsieovrnovscaotprioioronidorvwamelseuder.weictohFrdoeFtdhaXteasTBp{bL1esii,rnugbiiflnosBdsLaitLtarh.oabnino cwaesrtaZienpovratleude,asca<0l.c1u.lat0i.o05nsvwaesre -- --~ - 7 Company Sanitized. Donotecontsain TSCA CBI ~i f2 Br21 S5d5i5f3i2s2d3e2n0d3 a3d3d8d3d3d9d3s2i9d8 Be GIENIEAEE GEEEEEEEE ~ P|i e mmm sma . B3| o4 3ae GIAEEREERE mRENRERE ggddgssssd nnsdudnndd dg pe : 88 ggeIINN 33aeaEENm I3iIioaTi oS 3I3SinedEd 23 &3%g aARsasdsieurinisdes 2 aSssAssIseNseIs SE 5 22g : susssEEEy g:o sEEsEEEEs #9 2% 5 ZYTEIESEES 5 SUNREREEEE PIERRE ER Company Sanitzed Does not contain TSGA CBI ~ iZ| 52 y Be RIIIEIIE AEEEEEEIE ~ Pi el g FI f 8 E32k FL.2 opm asnsngsdesasasnsssad siessdsasseamsndnsn naam aArsisnsadasesnansss adsaazsvdensiasses 5 B+ gs3sdddedd desmecedsd 3i BL3 GENE nenmaqmaan pB HERES wanaoanaan %` 2 2 poaEdENEE OR BMEERAEEEY 24 :0 swexsysees gp osssszsEsss a2 HER HEH HH . } : Company Santized Doesnot conTtSaCAiCanl ~: z2 ~ 1, & :gl i- 3g s2s3=535=5=5saadndnE G2%35d8dNs3sdaAdRdnsR a 33 | = 2 3s3ssssass 2ugzssssan 4 # mammmn nmaEn 8 3 guy9383%8% n BIIINAEy 23 bE i2 2d ~%2 E3p oglrizdedsdaeniiaeds posaaedalgauasdniseesc i 2 if4 sGgIgRnIgRgIxEsNsEsE E . yG sssA nesN sss ys sesssessss sszzgzasaz diEREEaEE vaEeNess `Company Sanitized. Doss not contain TSCA CBI ~ 3 52 3 ol } ; 1i FiH:| 3 f 3% mmm IEEE 7g 333EEEEER IENRESEEE ES IE3znasan 3IEIIEEE &$ : $s3s5n3z3sEs3a3n2a0s 5 233ERE5E3IAIsNEIETsI i34 | d2d2f0d8a8d3d8d3a8s 2I d3iRdNdEsNdEaRdRdIdT iy g 255235RRST 4 $49ARARASS . . Company Santzsd, Goss ot contTSaOAiCBn ~f 8 mbieEsml mnaEEEEeE jE EINE ENN ~~ Pi el omni BIER . g I ope mmEmE aE %ee mmm pumas 7 de INNES SINE % JhIniiedes Iiaddddedd i:: &2%2 Sseisgdzsnasdeinaass $ 3o3a2s3s3su5s3s6.3s7s bHEy :: 2 2 0 smxezzzsss pn sssssssfyy 5 i 8 gzsgzessss { $8333588RR Eg 22 S3nisseEs g fssssEEes ert Tca ~: $ aaamasad mmREREEEE Bo EINIAEE BIEEEEREN -- 3i B30 i 30x GaAEAAnER IREEEIEEEE REAEREEE REE z ; Be GacanREd sEMEREEE 3b EEE 1i 83 33R334323F $ Tr 3 8 I3IEIIEIsE 5 ii i . ssesersses na 25 SEEEEIEEN ; koma g g ssEEEEESNS 5g } ~ 84 i a3dsganyy g EasyEsiNgd Gompany Saniized.Does notconTtSaCAiCBnI ~ "llf fl 345 | 5 2% 3EnIEEEIER s3zg3szssens reine RENEE 538383ug3n 3k IEEE EEL fmm mien Hl3 iH1,e8s,Iunneai22i34l0 of AESsAidnssEesl.teend BSlE aiLF mmmnn = mms : - 2g E SE38sEREE3 g 33TIILIIT [ES ---- ~f --~ 3 2 g te s3gussgsss 33azReass jl Cg mn mE 3B mEmEmE EEE Cf5 E3,e spusssessnuzy; aa%m33E33E8ImaNs } 3a2 EJe IEnniialeos rEF ooaemasiennngs Hl 8! san; momen 33 3 g ~~ a2 1 ; BMgEiiatE ssesesEae Company Sanz.Doss otrTSAaG1 ~% : 3 23 gpm NEEDED J RINNE FEMI ~ iFae5 S2RIAIAnRAaAnAaA:R R8B4EREanie i er 3 2 Ape IT3IinEEEl tGaingesmsncoaesndsn EEE NEEEEEREs gaassseesdasvceasst IISIEINE : 38, 33ND BEEIIIEEEe 3 no2 ~3 #5 , 3333330 7 IIINENEL g 7 swsxwussns pi osswssssnsd i $33388ESEE dussILEEE :} . Company Sanilzad. Doesnot conan TSCA CBI ~5 3 -~ fi 8. gl 8} 3 33 zsssszsssz Sdsssss60s ssssasass, Sccsssas | 2 3 sgszssesss anznzasas, dg EINE EIENEEIEs & |BF,E 3333330333 : IEEIIENEL gBai2ll EE3o sIuNmEEGseITssE DMsEEaeEnzERiaEeRs 3fE2H| B 3Ny7 o525o 3389m 38] : 3E RENM RENY 53 15 syssazeass ssapsansss 2g i 8383333333 g seas CompanySaniized Doss notconTSCaACnBI ~ 3 52 Be 3ER33EEEEE EEE ldPEG og mmmaR Ite ammummio a EERE RENE amEE de mmm EEE : 3 3 EEEEEEPEEE gif pam 4 Ce it 0B sxyxsssssy EL 59 ~ 3$z3l Cd 95. IEZEESEEND 423 = szszcEiassdsaensdsn 3 EEREEPEEEN | anne Pb FossEussssEs g . S28AEEREEY $f sZsHsAgNeRsReAnSeDs . . `CompanySanitized. Does not conTtSaCAiCanl ~3 52 5 333333333 GEREEEEEE | PJaere wonm an mmamn Bl sox GEEEERASEY HERE | foe numnn sues Yoo mmm suman orf mumnn f annun g5a| oe 22eaninaamnneiset gp oaouiEeniacIrRaasa iH 8 5 588555588 E EEEEBEEBESY } . ConsSaised, Dorn ~3 H 53 3 : . q: 3| IFE ad IIEIEENEG szsumasasn HNEIANEE s3asTaRssaes 2 1 2g33q gsds3sdgsnseasdsssy Bd3d3sAdEaIsSaEsSeRs . g IoH2 2938983353 %: 3333803383 HoH i Se52%g| 2EE3 p gdsdssessiesdnasdess B: 3od2s3sad%sea3s8inlds 23 3 S2. pjgaoisseNsmzIssiisy on 3I9R5A5R3E5R5E3IE8Y8 g Fo f a499 4gpps stREAsRRNGSEEiEnSdE o.s 8S2M2M3R3I8N5G3EM3 Company Sanitized. Does not contain TSCA CBI ~3 | ig pmmmm onmmam fg C3 anaEmaEE EESINNESES 5fq 81 mmamm8a mmm pENngEesSS 3: 5HER2E E guegazzsE es anaE ussasay . 25 i 2d %p ssnazarzne g sedesiasad ooadmdadzaasindaeasr lpm mam CompanySaitzed. Dossnot containTSOACBI ~3 3 3 Ei $f aspaasasd te GaREBEREEE Bo IIE33IEEEE ESEEEEEES ~ Pi y numEs BOER 8 fpr mmm msm Bote mmm mmm 2 : go 2383NEEd GEESE 3 BS naan : foasdigddd 1 of {oman funnnn i EL 3 BEEEEEEESE 2 EEEEEBEELY Sint mA ~ $f pmimimd ssRaREEREE Bo EEIEEN RARER Bar sian amin J poe IEEEEE EER 2 iiisnddnd dddnsdnass 3dow -GEE EERE i g sf 2s 2 EEEEEEEEEE] don i znaazsaIag . 5 BFeT I3SEIINEED gFP HENINENEER 2g : M 2 i 8% f sszEsEssss gsspssnes [---- ~ 3 32 --_ 3 : g| f 2 gages3sy3s n99sIEnoss ! 80%Cag3 iqf2 smamsEsIsaEnEaEsRs mmamaEs sNs3sEsIsNsEsNuIzEnD nnunnaegns gss g i E3 p 5 ao zgee gsam nsn 8 4ER5m93E%aRseEs . sf 37 ssgsagenss I gauzazsend : i i : ifdddcicas 3 Gacraveeas EY3 38 ~3 B2f gRusEesNsnEgaEz a; 9m358a338n 890 ars onan anand i i gegggsses gEeEEEagE Company Sanitized. Dossnot contTSaCAiCanll ~: 3 z ; ; - z j 3 usgmzssnss 95332533 ' 1. 83 Fugts 1 s3s3s3s3s3e5s3aEzE:% oman dsssszsssnszssssssss ommend fF3%pgeo namsm agns 3m539m4233m583 . z . nme f na_ n H EE Fd ~~ 2 3% agsaszgens 4333333833 8A 55. e3BRizEsss . 833383383 i 7 sSsEssigss josasessness Company Saitzed. Donoscontsain TSCA CBI ~ : 3 msfsszisad sasieaises s psaaiEEE nEnBEbEEE pI REESE 33333308 | d= e ommmEn sRREE f 8 ses IEIiEEEE IEEE fl Tee Eide Emm : 8 gp. pie sagiaEd $& g2e3 iEE3EzEzEzEzEiEaEsLa]s : oss4a4n4a4s%EnEm 3 g amsERInii og BARIIEANEE i 8 % BEEEEEEEES psussnsnns . | . CompanySantzed. 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FEE EERE EEE2E8E ! 1 igggasuzs ggEssEEEsg Yio fesse folie ~ |: : ; i aE na I 3 Fg ben HE B HH I 7 sesessssss ; ssgseesesf 5s 3} { 233358838 { 3553553338 ] pr |ri. oofery wee wena bon 1pfu e go E i Dio hmmm dan ig Fay uv = 2 i i % gaaszanses geesesness | 35 : HEEL EEE : grgasgress : . i bom oiei fl pe g&empg e gjE unum don mE i % :ssssansass | aseassanse : Pomme Died I HH ir uf ; 3 Joie mmmmE qHEER Ji : 2222922288 : 22222829828 #9) 4% 5 3244885253 . 233EENEEd 1 goondd elms 3 . . _ : i fram] EHR ; CIRER I I i : ir 5 sasassazes ssseseesss y ! 2322582823 ! 38538538858 ~ i: 3 pd eg i afgt bronx obi ;, doiF EOE mEMEn Ham I-07 | . : 4 P i i 3 22222282288 : 222228828282 CompanySanitized. DoesnotconTtSaCAiCnBI ~ is srradransy Crees i ji g; Bogor =py . " z : B ot : : S if p mi mpmpie? pnRunRsfpenmyy 28 42 ; BESEEERIEY g sEIEEEmEes ~ 3 z3 i i! - 5 2 gl @ ! 82 qi 23 : z 2s i g i3y op. s: smmmmp: maEEnRRReEEnRR E28Y IEE zzzzoeancs 2 papgrusass EEI 2 CompanySanz. 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CompanySantized.Doesnot contTSaCAiGanll ] ssoassssse ssszemens $1 aim mmnassies 8 angassznas namsasenen PPaEt msmesmdmissaisitaess Sgeteasimdeiinase i 43 gses3sierz 3s2sasdss . -- 3 8 der gi i 3 3 IE EEE smaazmsRsn mmm AaR3easdag : 3 sesgsZsear esziaasfss & , mum babamenes 13 5; seasssEEr { aneeenean [<4HIRI 2 HE H 49 ms 33 i BE3E2ERgaY Dissnsnn: i i gggggggese i gi3gizaais $8 sssamsasss sazssssens fl GIES ImanEEmE 8 gNssILA=NS 2qn8nSLens : 8 IIIEEE IEE _ i 3 gsgssaggsz 33s3iEREs y ; 5 GIRAINAIEE IEEESREER g 3 i BS SRRINRYAYE ARARIANRAR 5 55 eesIsEse SSRIENR2GS ib nm; nnn 3 a 2 i ig names : ferasagess Br mmm : Hanan ~i 3 52 3j iddssazis <j 3EIRININ sameaaiaas EELEEEMOME -- :I H28 cnSoanmai=Snaaeilt ma3nneaagtsedneadtse 5} igl 8 figs smnsmmemnamsems Ecvmsscamuamne ; 3 8 mmmmman mm gos smmsuuianoosmazomum 28 22nenantan eqnateane 1 0 : EzE3 BE$} g;. ssaensasdgansezsisas f| : Z5e2s8a3z3s5i8g5a3g 832] 5$887 smeacpeeesssssssesre u zsseerasscsearceasrs i 7 8 l 2x & necoscesse & mamnsEsase 2g ii JUUEIEIERE o ISIE Company Saized,GoesnotcontinTSGA CBI ~ 33Z2 9f sagasisss sazpEassss -] REURG Benen T: a mgssagsnsanas mdidmsssdmsse ~ : 28 BY nuedotanen dsmdddasan mmnenneees aman PE mmm BIEN i8 i#,80 smmasman amma g 8 nwumn mens 7 3$ #85. 8 TsReTnEaRnIeCnIaInYs gp eIsneEvRiRasEeReDn 252E 88%8 5fa agsimmssereezzeazzsa i i zosaoszanzamasssssas: gE : 243 H28f.7 sseaoneesmsneovnaern ogj sveermsntemmvmeannes dH smd wn 28gz ~~ a iF iesemses ossssssesss i S ZEE2Sa4a3% FILESSNaEC 3 s 33888283838 38282335883 5: . . - CompanySac. 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Dossno contain TSCA GSI ~3 3 53 ~] WHEN Wan : gdssgsssss gesndingssd 13 g28 smmoomasnaases aevesasnsmasnmveesn --~ 3 g i 8 BREESE BEER Bl 88 canzmoiang nnmensenae do smnmianan snasananss $ ? aqsaaernrs F enneeaence BY gp SARR3A33%% LV dada z3z3 82 i2 22223325333388223528 5B ZdzzeessaessiSisul:s 55 7 3 i2 E8% g5 zsesesseze g pesenssas;s 9) 13 eonnanenes S83FRRIARE CompanySantzed, Does et containTSCA GE! ~ : 8 g3RaeRsRss ssagessen ] IsamzasEr rsiisazsss i zassasesas snwzsganss iIT5H8 s 23ah 29%a38%r3n B 2auu%sa fnsan = i is SIRGARRIAL RGERTILRRL . i 3 i i 8 GidaRdRdii REEREE : 83 sesfmsesse svsspuancs Z| 2 6g sesgeesees esgeszacsy i 1 if nen sanennes . i i : HEH i HEH UII ITH EH 8] Zezzessrar srsrasesss 3F 3E3IansEEiEasauaAnl mOaAmAmIaRmInIELmERS EY 3IRnBNEERE AsAnaAm'AR PEuEsR sf39%9ndadodasedss:d sdseadsdseseseaesss _ i 45 cwsucersss sseee@aner " i 2 : 3 Sssossiess EEEEIT ITE] i : feesiaest ! EEapeaan . 4 i SEREBERY MEERNMM Pe; mmm sane ~3 8] aEeRERidai SERENE <j IREEENESE ImanIEEm 1ie3 m EoEmEo L FSuR _ i288 soaznocaasvuauezas samssnmge IRENE ' fF smmmnumnooamnnmananm | $0 mmnozmIme mIIIIINND & i 2% SE i 2 ~ 8 % | ed458 mizzzszan 2 osizansanas 83 {25 ssoem3arpassssssasgg : semassaadl : # 8%3 ? searssesa2nn !% EaEsEsEaEnEEERE a5y :o SE3E83E55E 5 iBgIny [ET ---- 2 ~ F 3 5 of HEE AsENE 3 Ni BdIeHnRnAnRaIaRnEaR $BA5R5S88E2Rn83e8e5e i 1f 82)3 vmemqmcemcsroesms srmenaemcoawnugae } ~~ i 3 : i3 iy8 adndadsdqdedssad~da ascd~desndasndesadnd 38 mnmmumnm amu i 3 nummer nm 3i 08I 5 amnmnumans p ocaner enunas 2 2 i: 5 F gzzzsanss g aisassiisd 2 : : 9% f seienscnss zaezsszses iH i 2g 2 i se88EE8LEE i se8es88Ese ~ ; G5i E8 3333333383 333s: smne n : pgm pn Pe; wns mmm ~ |! i gl 333gisissd gisIsgisic go Fam Taman pf Png mn Bp: omnpmnnnnn ; : i 8% comssssges #onmmmm ] swessaazas J: ogty s43p3m3m3m3e3a3s3e3r ssesssesss onmEEn mssanasEss 3g3m3m3e3w5s5n5e5a8s i i snearvasse BREITREASH . ! 3 8s fAnfAgsEaS SdfSAsInNe 8 i $3 sezmeazerss Ho8snsseald ; B53 saisiiifas Co Ed mmm fp mmen Bed mm Isfseedsed pn m anim + IEENEEGT mmmmm Pe unum monn: i | GARERZAAAZ 9ARARREAR ~ I PE smommame gasndmasas %. 8 f8 3d 1Hi iFges 38 BEEN <mmm =3encnuene aEEEm amu aeeswesany 4 +28 msm osmasenn gg fFg: ` 23 $E8F }2 WsRaRzRsRsIuRnIaRsZs 3 5855235323 WURRRIARER i 82% ssemsssns | anssaneace 83 27 BBEELEEEES 7 fasssdsess Company Sanitzed. Dossnot conTtSaCAiGnBI 3 Bl cman osssamosa ; JE : fEsagaasee ! ERRaEREREE igo:i ferassase $: gEigesane dl 0: em fn ~ 83 JITIIJIIIZ 3333333633 ,Pomimnm sme med , mI men amen HE gFEH meee stnenthhen ofese ofmegibpze PS iF HEE HEE $ I 3 x unas: SRNL ) : pi 3 BE 3 HR i $5, g8l ap casssangdr :3 ; HH cC o mme mmmmnmer gaapnsaas amEazEnm : {HIN o: BHgpmL EEaam foamgmsnnner commrSamien Derm  8 333339333 ohfohnnhe s i m DinI 33%%3ddaaC mmm pdnen Pheer EE ~ | BE Gib Ci ; ] 1+ eedededany Seder eer in do mmm Eben i 3 : SifnsexsdnuBlxedd 3 wiles x3siEzizdy . gi vp DH EEN Gl sme sense --_~ 2 3 _ : iiHI : ii:1 : 4 : :. i 2 2 2% 4 2 SE EB 2 2%4 323 g3gseajessae xi gon3Bsngee 54 [TREE ER 8 * 3 i [ i& ---- 1 ~| ; il: HiIE : 4 |one i 3 g Z i53 :: 23 2Y8%. ~38i39 H35g? ood i i: : sZpsg%nscaesaersazse ugp si msaze aneer ssaaanseaazsseaafdss s pmnaamssiess `Company Sanitized. Doesnotcont TSaCAiCn BI ~ i gd goTIIIIISs Cspnn gtez, Efe BEEEEEEEH 8 EERE EEEE RoLLLNss mrrini maan de ByppuREEEE EEGEEEEEEE ~ | ie Ti ) Dae mE mnntmmm i 2 5 i ennegEefan i onntiofonn r 0 mEED lnamINE ' 5 EF 2i % Bi5f LsiEefmEsdsRaEeenRsE sfaasdseeRzEeesdeds :: 81 geEaNIIiIn ERS 32) 0, Hide gn C2ERI H i ELL. EEER So i 2 Copa. sestocnn ~3 3 3 Bf TITIIENIY 333NINIIN + fPyhsmmer.r npnhrrrann Elgsmmimnmas 5 BY gmawnavean ofefeegas ~ | DioFs lHimEmmmEmm mGniee 4 5 7 i is seeggessRr 2INNISNGZ SjF 52Bp Rssisafseausier ssrlaemdsEsmzReeses Hi ga Sussoagadi } MIadREin g23|ivLL2TRISH B25 IER a2 i i $3338888%8 $ 8835888388 Company Sanitized. Doesnotcontain TSCA CBI ~3 ~~ i 2 | 2=i" f23 3 3 2g i ov : 2 : : zg3 2E8F ,| s8gmAnRrAtReEsReScH S3gRge33zIaalnmAmEsxda 4 : 2 gel srnaanien oe ooEmaiaas: 82 i BEEIUEeses gees Company Sata. GosntcomTaSCiACnEI ~i 3 ~ 1 : gl = gd gl Z | : . 0B 7 & . . 2 . Bong Z2z 32 gp a3scEfsmgeennyings 3F asssAxi5 aw' 2 Pr. IRRIINGONY g Meads 2g ~ a43 i35 2S3EVUZ3EIELEREIREET + zgsmsBisss CompanySantized. Dossnot conTtSCiAGonll 85 3333330330 SEIILNILA cRf TI Mi Egomfanna nfaniam ou el8iIlT lfm wlapbune ~ | iDe F B mmHm F roH am ; J ope ummm men Ase ; mmm : msi 3| 8 E ; ER 6: edE EEEM giv. HH; BEEN ~ 3 al ~| 8 g3 3: EH i 3HHg SE E23 4384 ~ 83 8 58 z p AanAgEsasEsEsEzEEs F: oHeijeessnes i & ge 0 ocusmazicie og Hogdadied 1p 3 szmzamzasn 2 mammpaam i SSEIIEESER sessssgess CompanySaniized.Doesnot conTtSaCAiCnB f EH 33333 3333332 .TO BiEmmE mmr.e mBmmmemEssre EO opH p EmE mm IoHmii h prhe ~ | BF HHH Hi ; is 1sm30use anRRIESRIS ' i i saiasziaay fespsaieds i EEREEEEN bi EE otAEE ga HEHE HEE ~3 z52 ES 333333333 3osEsssss C1 HH1I .eh mmhm rman PEs f fenm m seeeeE sees --~ Doe gmp PRODI H mmEm . Hi 322223} BRR : : 31 j33ssdaaze amma: ji) 8 . let|:feanmad B3 oer2 HIE2 Hs i3 3 i: EEEgpyuBEipiqsesEE : gBigEEnaisnieGt mireSeid, Semone ~ 2 -i gy ' 33 2 aE ! 3 I:: Si: - i i2 fi E: 22 ed5 x snmagegesn 75 osazasasnsr 85 $5 ; S5EGERRES s+ 3iEOgELESE CompanySantzad.Dos nakcontainTSOAGOI ~3 3 52 - | : fd 3 i 3 i 3 | ! 8 i: z : 25 2 B 3 : z <5 2 ed 5 |:J -- 3 3 2288323482 > IIRABI2REG io ry : ~ %74483 gg u3351 y 7 sSgse3mgRsg2i2ag2mi8sa8ss3es%s ;, z3aeFfzAEzTEzLasInReaAsiAasDs iH i $3388838383 i 8 Company Sanitized Does not contin SCA CE i 83 3333333338 33%sssasss Pf SiEEsEsEss fi Bon. BEEEEE ;ERmmNmmEm pirnoen PB H mmGm oni pm POEgLe mpm mmm i it 333!AIWN [IME 5 84 3323333371 NsIRIEEE gi + HEHE HON Ml $5 5 sraEaaEesa HETTTYTI eS i 83 333333903 LINN3%sl TE spseI eser OR iBo flmmipmem mn nznen s a E mnR Hpmamcnoea in GE Haaea : : = it 3333383338 33ddamil : $i gITInINaI IuIEasn: i. : FERRE HEE ERE EL ~3 ~ |i 3 ii : yi | 3 ? i F4H o3 r% ceommgennas : seaszzenss 34 ! 3 & Mgmiy Beages 3 ie 8 2223343 SN mddcevBann ~~ 2 #1] 8588828888 i sREeBsElEs CompanySantas. Dos rotoSOrA Gsl --_ Z| ~i iiii 14 i . 3 cd i &Fa : a2 Bil| 6B3 T5z ieineesneeunsssess 5BE naseggmgemeenntisss Bd pes zzanannen Meade 85 gy: oesmmmnane: os pnEAnE 28 2 CompanySin. essenTEAC ; 85 33333333 SIINNIIS + , puh mmn pmemn sHrampHaner panama 5 HG in ~ | BF GG (nd ; it s333EEEIIT 233A: } Fl gi 32003083 . 3333333 qa i ~ F3 2 ~| EH : a2 9: i ) EH es 2 smeesasnee 2 SASISSRSE 2 I : 1 se smmmeien oomanenn ~ ig i B3EEEEEREE 7 siananenn GampanySeized.Doe rotcontTSaCAiCn1 ] 3 ~ 3 ] 2: f 111 : gP g g et wmf GEERREEERE E8gat mpppe RREEEEEsEE i , sangnniel : BEEEREEEE gil b , oRIEENE ODINEN $5 B 8 FLIES ER EH 2d ii f Sg3338882% i $838858802 2" . ~ Ty iiey pl] hlelfell nani wemnnadief ; i it Hijo neue i ; mmmun mua .3 : iERgagane i HEHE EY | TERRE HEE 1 I, 1 ~ HA I & i 1 gum fii die frum B13ERERERE i i {jun naam Iv, meng pn gb; mmEm IN i ; Hen p Hp ] {ie fo 1 gfe mmm Jeanne aja | : fn 3 faasaagied gr pees pnnenn HH bl ms : peaeege j ] i PL = - i r asf BREEEEARER : : ii mmenm spona ; Bo 1b gil 0) ii : BBEBssE3El ERBRREEESE men paen me| nn nn pte nts i 1 Fe mmm mm : qiii fen rjfj:oeee] ER meee 30.5 mmm mmm i Hn uns LIER Rg HE be] 43 0 reazsssEna o S282I3nEas ELE 3 ii fran JHE 5 i BEEEREEERE . EEEEREEREE Cd bom|e omn sv Fannnmee r Hor comm} onan i i 4 - ito 1s 5 {11 wo : : E BefBcfERE: ERRREREECE ) Aor meme dduind fF Esfuemmne pHgEREeE i 1 : fefeitfe BHREREERCE sb fuera | on {i ; mite : spEn REE } ! ~|i : J i: r ummm pen 9E ii: ufjsue Hesannee i : Poona mens 10 man gen E5 fF HHH Heli Hx nmmenn pst 4 "e 2528702237 FTTTEIETTS P Ife HE 0 pam BeRBRERER} sds sfsfesesfs i Po BeBBEREEEE slsieeecf 308 mann | de i23 Bf2geprngil ig efe.desuss i ; EeREBRIEYY ; sagasaey , ' 9H02.5D4a2y5;GaSvualbgchSvtoundiyc iTnoxRiactistywith One-Generation Reproduction Evaluations --~ Dupo 11418 APPENDIX L -- INDIVIDUAL ANIMAL BIOCHEMICAL DATA FE ---- 80 `Company Sanitized. Does notcontain TSCA CBI H:25425: Subehronic Toxicity 0-DayGavageStudy in Rats with One-Generation Reproduction Evaluations DuPont-11418 ~ IndividRuaatls AAntimTahle B1i0o-cDhaeymiTciamle DPaotiantIn Male TB T eta- mio mi sidatiRao te n Group. Number (nmol/min/mg protein) 1 668965 17.78 668966 17.81 668967 17.19 668968 15.39 668969 19.00 111 668970 20.62 668971 15.69 668972 19.62 668973 18.53 668974 18.39 v 668975 14.18 668976 15.28 668977 14.86 668978 14.24 668979 16.38 viz 668980 18.30 668981 15.30% --~ 668982 14.41 668983 17.11 668984 13.82 *Dus 0pipetertroirtnhigs saimnoptinlcludeed in the calculations. ~~ S81 `CompanySanitized. DoesnotcontTSaCAiGBnI H25425; Sulbehronic Toxicity 90-Day Gavage Study in Rats withOnGeeneration Reproduction Evaluations DuPont 11418 --_ IndividRuaatls AAntimTahle B9i2o-cDhaeymicTailmeDaPtoaintIn Male Group. ASnuimbmearl. (nBmootla/-moixni/dnagtipornotReaitne) x 565047 19.32 665049 18.05 665070 17.59 665130 18.40 665076 20.18 mm 665053 18.77 665074 17.74 665128 21.07 665080 16.83 664993 15.97 v 665122 21.06 665155 2235 665073 21.07 665089 18.49 665119 17.60 viz 665160 32.78 --~ 666655009862 30.85 28.87 665107 27.81 ses1s2 28.40 --~ `CompanySanitized.Doesnot conTtSaCAiCnBI 1.25425; Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ~ IRnadtisviAdtuaTlheAnOinmea-loBnitohchReemciocvaelryDaTtiameInPoMianlte Dupont-11418 Group SAunmibmaerl H 665043 665098 665149 665081 665159 vir 665007 665112 665138 665062 665146 (Bnemtoal-/Omxiind/antgipornotReaitne) 17.79 15.79 17.56 1.53 1.41 26.40 28.68 30.98 20.18 17.80 --~ --~ 85 Company Sanitized. Does not contain TSCA CBI 9F-02D54a2y5;GavSaugbcehSrtoundiyc iTnoxRiactistywithOneGeneration Reproduction Evaluations DuPont 11418 ~ IndividuRaaltsAnAitmaTlheBi1o0c-hDeamyicTailmeDaPtoainItn Female Group AHunmibmearl (Bmemtola/-mOixni/dmagtipornotReaitne) Eel 668987 12.37 668988 17.48 668989 19.76 668590 13.20 668991 16.80 wv 568992 20.01 668993 13.66 668994 13085 668995 19.66 668996. 17m vz 668997 19.18 668998 22.16 668999 20061 669000 16.39 669001 17.6 vizz 669002 14.02 rm 669003 21.49 669004 20.84 669005 20.71 669006 18.53 --~ _--_--m ww -- Company Sanitized. Donotecontsain TSCA Cal 25425 Subchronic Toxicity 90-Day Gavage Study in Rats withOne Generation Reproduction Evaluations DuPont-11418 ~ IndividuRaaltsAnAitmaTlheBi9o3c-hDeamyicTailmeDaPtoainItn Female Group. aNnuimmbaelr (nBmeotla-/Omxini/dnagtipornotReaitne) bd 665211 19.05 665271 19.63 665178 16.60 665317 20.26 665230 20.22 w 665308 22.73 665215. 19.19 665277 22.02 665201 17.21 665236 15.88 vi 665295 17.32 665251 23.19 665300 20.93 665300 21.96 665259 21.46 vizz 66523 28.23 665262 21.90 665183 25.29 665261 22.95 565291 21.70 --_ -- ws, CompanySanitized. DoesnotcontTSaCAiCBnI H:25425: Subchronic Toxicity 90-Day Gavage Study in Ras with One-Generation Reproduction Evaluations Dupont 11418 ~ InRdaitvsidAutalThAeniOmnael-oBniotchheRmeiccoavlerDyatTaimIen PFoeimnatle Grow aNnuimmbaelr (nBmeotla-/Omxini/dnagtipornotReaitne) Ed 665276 20.71 665201 2.21 665197 18.92 665256 23.82 665323 21.05 vizr 665275 22.09 665229 26.21 665237 22.73 665209 20.23 565335 25.60 --_ --_ -- me `CompanySanitized. DoesnotcontTSaCAiCanl H25425; Subchonic Toxicity 0-Day Gavage Study in Rats with One-Generation Reproduction Evaluations PS DuPont-11418 --~ APPENDIX M INDIVIDUAL ANIMAL BODY AND ORGAN WEIGHTS - Company Saniized. Does not contain TSCA CBI ~ BE AiGnp SRiiddm enma TRiimmes F3o1 hlol imiinminemssr asol hipooiuoonanaasnnd [E1E PrBirfefsrirsdrsedeedepfilli |aiBipdriesrseseaenra)) i !1 i E giseR hsseE EessLsEsi (| -BiEgEEsfanus Pr pammmmes ozs ~ `gi1s 3 [oHESRHIREIEEE Boni nyyf mm EEIe MG {8% isdcscecsds Sof 1ESidddsdidli i; I RRs he PHI i NFTo s digEihsaane E BR fiasiEsEEREmEEE PRC Tf Ri 2iooecet 'fl Cb Ean Tl gizmsmasssas ga faa op medeEeRE ' f8aF3 |1 rPp nmpm e mpe mm n gn e ae ae e n CompanySaiz. Doesnt contain TSA GBI ~ HfiEg,) ((BERRiInEt AneEi mgEpjciesmsavmiemdnder on) g JIeTg 18L.03E8 I33 5.EsazE agsmT zes en ' BLE ER RT Cd BREA Bg piEm a la i! I ns aE Bi iF iRpiEs gE hieppmasciiniE ul gi iii Ti i gf EBE51| ai d ~gH5 0 ph Ee EEE Eg lpm 5 8 SBiTiTtEol Egl fgiiiiiedisdiadgydE %i |E im-oig g plas si l m ampE lig izgcssamnes | | i | Company Saiz.Does notconTtSaCAiGnBI ~ i 1581 5 i {3izenzannans75 #1) pamny dy | gomenmennm gn! TI I mH mE a a ~ fig fLFe mda h(| pEua aamnemms al AE 5 AEE 8 Ii nha J=2| ||P | Egigi7R isssias zasal is: a 5g 3 E pE m i mR amo ma : ii: Corn, oes on T56GA3 jodi gu ~ i: 1E3sg 8 (3 izes: sass eel |:izEsssass! AF BREE agEE gn pmmamman 51 iFiiaees moan sai [BFSSSeiess dl iE IEE gE Id Ho epSlEm mmmmme ameEnn | memn pFoime B00 IF izaatemsaiosnl C ismmsasas) i | LFS 5 [gjss Tolip Bos Ba ne FE g i 0838 | Emme i zisesgssanes d33efl fgisazaisassy I ees | || Pol si, ssssascast 1 isddddhssds asi ssf bi sssseiss) gf Fisdddaiaii Pol RIS Pong i g3 Lgl isdsggnuasd id) Ii iatumener! 72 D| o| npl E lssmE sssaEsss Eaioe E lssR esaE sm| ~34 HARLAN ; ; CompanySanitized. Doesnot conTtSaCAiCBnI 48 qos EERE di Gms Fide ad | mnwm lasdaninnas a on) sl i 3 = | ynmns i Tofip Bo: Ramen | He pia gas a fBeist0% ii PH Hzisoeoanl gies SEE 8 dl opizrmsmesses: flasuienana a2lg) iia idea 3) Jjssssasasss =i SERER EE di i;igma is3seasenss xl Blige bignum a 3 3H 35 0 | EFpIR TmSe B pSEaaa EtiaRdds dEay : ~3 0p EER gE EEE CompanySantis. Dost aman150 81 ~ ioni jj a gi 8 148i Timer HH i AGHA AGASA mo| ERLE EE Iz i iE' isoeussassn ig {E-15558538858 2a. 83! i411 sizsssssexes 3 ig | fineidddided a3 3 Boman Ei ! | Bisecdsessas = ~ lBiiiwg3g) p || Bp{iEzCpUsReGaAm mSsEeEEs afa :. 3 BB ares 2 Fi5sMt grime gi SiIIRICASRAR Roay Bi igi idadeddaecd sai A9Bi | szim, l ZESERESEAS E53. 3 ngiER TE | IRENE {oto ~ Bgl | | BE EEE i i CompanySiz. booomasT50t01 ~ fEHEe Co 88 igh ZS lsssem saReda s gel |{gfilmdmdaansasnesdasl! EI LS 30 imam al | mses JGuFd C|p EaEEsEEaEsp Cae ma bomen bane HHBlH8Ii E*| E 13ig8e i5sn33e 38883 B3EI i Ed B1I s Zoi3nw a3Yn ASN. Bi dipiahaEgEanas an. ltpanEaEm ! EE = Ian sl jEag Ips 24 PoE pm GE EEE 4 3 gimme a big mee ~E EER El EE Company Sanz. DossnotconanT5GAGa ~ gx INIRE FEE Ie] i DoE il jLoEI BTEEEI b pEe mai mn gPoopDEEaE |h pammm an a Jiups H {lE em = el gj| BoizAieRamEenenn a=ni W0 isg estSa ms C DjeEEeE rpms 3B8 f:ErMiegHYaml mmo dd d Coreyt,tcasa ~ hd EERE di HES 11 jimmy 0 me - phi eg gn ou | Yak i i 1g a d i i IE = gi af | p EpE m 2] | El jizazazesass ap | } i 5 ~83 i HERE i i cmp Snr ~ of E 18[3 go |asanm amanne y mal omgine namaease pooper i ig! ii I = 1983ILILANE RF j jsssssisnss sei fens I = iRSRA23%R i Jisoceass! 00 lpsfmiTmnainnEmENEE aa | gRiimsmeen PTaoll p Bnam 82 iH gh izess azase, Bo puma Comm aBeEll D| gRlemIizzEanaRns gr B| imEaseEenRnn - (1 Bama poo : ne A i, EE 8 3 iszmenznens ml 11 4 izemeunen LIER EN go REEED hime | ppmmEme a ESER | | 2 lssssaseany ml 8 nessane 3 {1 I isgmmeeren pel oi, vEERaER gil | die Lg E 1 i ila 1320038089 281 iEx ASSSRANT $9 00H pIEEEEE ED gid 1 25 0 piEissssssesm BRoEsssss CompanySass. Dossnotes 56 G1 48 Tow Sommen EF HERI fiFF 1 BigBLids 33 E[ggilcSleliTAnRRE EE! 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