Document kDzOOY8VnNve1p2ogn33V1vZJ

STUDY PLAN Revised 23 September 1996 COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY TESTING OF VINYL CHLORIDE I. Test Requirements Contained in Study Plan Inhalation Two-Generation Reproduction Study of Vinyl Chloride in Rats Inhalation Developmental Toxicity Study of Vinyl Chloride in CD Rats II. Administrative Official and Project Manager: Robert A. Venezia, Dr.P.H. Manager, Vinyl Chloride Panel Chemical Manufacturers Association 1300 Wilson Boulevard Arlington, VA 22209 Phone: 703/741-5639 Fax: 703/741-6091 III. Testing Facility: Huntingdon Life Sciences, Inc. P.O.Box 2360 Mettlers Road East Millstone, NJ 08875 Study Director: Raymond E. Schroeder M.S. Phone: 908/873-2550 IV. Professional Qualifications Curriculum Vitae providing the training and experience of each professional involved in this testing are attached as Appendix A to this study plan. V. Identity of Test Substance An analysis of the material which will be used for the studies will be conducted and results will be available when the studies begin. VI. Study Protocol CMA 113416 The protocol for the combined inhalation two-generation reproduction and developmental toxicity testing is attached as Appendix B. VII. Test Schedule Developmental Toxicity Study: Initiation: In-life phase completed: Progress report: Final report: October 28,1996 February 28,1997 March 9,1997 August 20,1997 Reproduction Study: Initiation In-life phase completed: Progress report: Progress report: Final report: October 28,1996 July 28,1997 April 14,1997 August 31,1997 March 31,1998 CMA 113417 2