Document kDvX6YVm6k2nEMynMko8YyZKE

ACUTE TOXICITY TO AQUATIC INVERTABRATES (DAPHNIA MAGNA) T TESTe SUBSs TANT CE su0e 0 0 st0 a0 Nc0 e Identity: aPserPflFuOorAooacmtamnooniciuacmids,alat,mAmmomniounmiusamltp;emrfalyuoarlosooctbaenoraetfee,rrPedFOt,o FFXC--111060,3.FC(-O1c2t6a,noFiCc-a1c6i9d,, pFeCn-t1a4d3e,caofrluaosroa-,maajmormocnomipuomnseanltt, of CAS #3825-26-1) Remarks: FX-1003. Its Tphureit3yMwapsrondoutctsiuoffnicliotenntulymcbhearrawcatesri2z3e2d7,. The test sample though current is ipnefrofrlmuaotriooonctianndoiactaet,es5i0t %is waatseorlu,ti<o3n%ofin<e4rt5p%erafmlumoorinniautemd compound and 1 -2% Cs and C; perfluoro analogue compounds. tTehset fsoulblsotwainncgesiunmwmaatrerysaoplpultiieosntwoitthheitnecsotmspalemtpelleyacshaaramcitxetruirzeeodf the ofcotnhceenttersattsiaonmspolfeimwpiutrhitthiaetso.fDtahteatemsat ysunbosttaanccceu.rately relate toxicity MMeETmHOoD.: TMyepteh:odS:tatic aOcEutCeD 202 GYeLaPr: cYomepsleted: 1990 Species: Supplier: DEanpvhinrioaSymsategmnsa, Inc. in-house culture Analytical oxygen monitoring: Temperature, pH, conductivity, and dissolved SEtxaptiosstuicrael pmeertihodo:ds4:8-Nhoonu-rlsinear interpolation, moving average, or probit analysis Tmaeisnttoaringeadniusndmeargtee:st<c2o4ndhiotuirosnsolfdoraantdleparsotd1u4ceddayfsr.om daphnids that were Pretreatment: None. Test conditions: Dilution Dilution wwaatteerr:cHhaemmpitsotrny,:New Hampshire well water PCoHn:ductivity: 89020 mhos/cm Hardness: 180 mglL (as CaCOs) 03911 Lighting: Cool-white fluorescent bulbs with an daily photoperiod of 16 hours light and 8 hours idnatreknswitaysofma4i5ntuaEisnTMe'dm?. A throughout the testing period. Test conditions remarks: Aeration was not required to maintain dissolved oxygen concentrations above acceptable levels. Daphnids were fed yeast, trout chow, and the freshwater alga Selenastrum capricornutum once daily during culturing, but werenotfed during the test. Stock and test solution preparation: Test solutions were created by dCiornecctenwteriaghttisonasdddiotisoinn.g rate: Once Stabilityof the test chemical solutions: Not noted Exposure vessels: 250 mL glass beakers containing 200 mL. test sNoulumtbioenr(o~f7 rcemplidceapttehs):. four NNuummbbeerr ooff dcoanpchennitdrsatpieornsr:epfliivceatpel:us5a blank control Water chemistry during the study: Conductivity range: (0-48 hours) 800 -- 900 pmhos/cm (control exposure) PH ran8g0e0(--049800hopumrhso):s/cm (1,000 mg/L exposure) 88..13-88..42 ((c1o,n0t0r0olmegx/pLoesxuproesure) Temper1a9t.u5r-e20r.a1ngeC((0c-o4n8trhooluerxsp)o:sure) 19.5 20.1 C (1,000 mol exposure) Dissolved oxygen range (0-48 hours): 99..10 --99..55 mmgg//LL ((c1o,n0t0r0olmegxlpLoseuxrpeo)sure) RESULTS NmgolmLinal concentrations: Bk control, 150, 250, 400, 600, and 1,000 Element value: 48-hour ECs = 584 (400 ~ 1,000) mg/L Element value based on nominal concentrations. Remarks: Testing was conducted on the mixture of the test substance as described in the test substance remarks field. The values reported apply to thatmixture and not the test substance. 03912 CONCLUSIONS 5T8h4e mtegs/tLswaimtphlae 9485-%hoCuornfEiCdsenfcoer DInatpehrvnailaomfa4g0n0atow1a,s00d0etgeLrm.ined to be SStu.bmPiautlt,erM:inn3esMotCao,m5p5a1n3y3, Environmental Laboratory, P.O. Box 33331, DATA QUALITY tReesltiianbgi.ltyH:owKeiviemri,scsharmapnlkeinpgur2i.tyTwesatsinngotmeperotpsertlhyecchiairtaeciatefroirzqeudalaintdy it lacks analytical confirmationoftest substance concentrations. REFERENCES -- Treeqsutewsatsofctohnedu3cMteCdobmypaEnnyv,ir1o9S9y0s.teTmhse, EInncv.iorfoSHyasmtpetmosn,stNudHyantutmhbeer was 9013-3 OTHER Last changed: 5/25/00 03913 So z } or Deas Bei ore Static Acute Toxicity of FX-100) TaAouth3o.rsard ;: san MEER aE Ek = L rneie HE R PEB RE Ei pMIlRen Er iEI goc ele ng el ni SrEnSindui bLEpSSCBe bre cal me Le SEER de a eid Ci Hib CRE nenas NE Ad Se SER E S ;5 003914 I. con wasmans mrs svar praceE lt pepial ont SE OTA ESTES, 1y,OyED, yC38 ambear Bi LaU aBeLtL a 494637 ee gi ; shag SR es ed # G Sa e ahTike n LeXowsnda SSEH ish LE Ggus i C RS G H R Rant Sign i ve BC Smi i semeCET M eE e BimbmmLed ddah nnaa ntsnaen SC eih Sa lee 2 Ch Gr a on me a mele SR e Ry aRR Qn A Ps Cagis SR we 03915 So CE ee Silly = = wy a BESTCOPY AVAIlABLE Ee ------ 1 - St br: pBoeontytoruoisceyaAtnnisatvsi,siToontorporated ne Latha nd --Rarpten. ek Tepize 03042 CORttiution: R mDiet E presstl E ed Sa teis nsepert seIco drriivreesd 2by meerhaotsee A oB LBarobrioocrriaatt teoydr"y"eaISnUnciucLFsorrrsuenpicSaeeplu:oreamptiait"nhgteoyFpaioroitoSrteaeattniapnarsceoJrSesarrloon.rSiceTnehkIeoeEol! rSnevonradlee"ld Ey atCLouTmloeTui reot Tdwidauetseoatnt boerte, fpneeeeovf:iigdinAvie j1 1TBTMro0iIr0ne,odPhuerueeratelodtrtshasidsrHoueeSrrenrrSsecsucSuedatfiafriocaSno,otretitrnhoqdeeups+orat1nee)sackn1aete3nSceeoeagra0erSrEErnieLEpioeSrdt ]p " CmIJosi.eerSLFtisFtaterrnytinal'e,: Taen shady pores 3 % 03% his BEE ne R B- dim E agiL .cdo CG ORSn2 E TEERhmO)ele Rad Yay +: B FSOppE Rsa a esE am Sm T L ao ni aPT IEAPR ReRRL E he E R Is D S A E,R ifs eoDfwecreeLa 933.70 Sm, 5% BFFAroG res gl ye nT P SZoR piaIt Sse $ Gi Ri RB aTo v vohrv ons suey uanLas sG01 GGUaRpRLS I sHts PRE : ae"a SLR TTEIR SEE x a Gps | Sais S SRRhBa s oettSh cr sim aha a "3 4 III. TABLE OF CONTENTS r section: PAGE E CL ant beaten pescicn sateent 2 E HL CurttticntonofGeo eratory Faction , i III. Table of Contents TootfTeienn and rigees se s` 33 `2 VI. Introduction 1 VIL patots wt waertats , ViiLrReensit wig GSkeRER 10-5 Ae ; : . PHEERT ais Guay maa tron oniTctyOTensRisRai adh oY SEE fBeae fSooenmietjtut E Ce 0DOERR ia SU NE a = rec cua E Ee Bal LA elena co LER wohA ER egR Yury iBSE CEhRoEaEgie e JeR RN UdReIGrR R REIL RR STE hel sons Sl Rs SR rel hihi: TREE Se REOR Re : } OLl ey iGgoeaan se SE EE A ai RR ect 1. uzormaues enrcmas . ne " "Table 1. - IfreEt pind Chendcal characterization of arepresentative . TB L Surin ts rom entetty ent u Tle. eTdieaattan ins cncateaions (Eco) u ete a Ce neePASTTne tro riien * i : faite AREEL EE sin Ee sei ACRE S3 T RRREERTT I AE TI eSBERRa Y Fit # v @ b CENReEE ae GTR leRE Cet a Rr en re idNE 7 :< Emme Li g oaR a aee ce BEeila E BR oca )re AAAaSeSa A SBIR NE 1 03918 SEen naane ABR B ko RnRhkeee a4 % He v. swar Te SfSeittmeepE BAlHe l,I O IEEETEhhTtE8,glE7aeT 0ytS0Ye1T0ant tihmircdeneodenlattsSSsoTnnnL,,151 Er ied TLEPR sHswirSr ysthTonkeholcEtoLn8tin ivnygon cBS5eatiTTianttdett" 0nS0reh,ieEdJodot bR oBinmerBr t pnyE RtS e thatt HritfPeEiR,E UTSEhS1S2,3H0 LtEntEEvTrs EdeETnLh00aA 23 vdn E neg eag arase : 4 EB nt s het S EA iT g es htdis Gaya 3 ; od ERT Ee : Hine Frog ad i 8 {3ide 5 Shi SHE Sg B RoES bE i Le me a a F he ie esi e S bP Ee rS ial ST 3 i OH R A Sp Ariston 5G mioT ;.: maR ta Seon el Xe sit 03919 a { vi. ormosuerion i otbhjeect"iduvTpehtiasiolf, sotutdEhyerasvShatusautdeyrsvpaoisnnsvoetrroetdedberbtayateiI.NnsCoTmhtpehaenryaa,pcouSrttte. ctPooanxutilec,iintsyHinosfaeecFstoXit-os1n.6s0)tThha3et dOfe"scrTihbee". ftohreust`isoautthioodns.angTheaatreerpiosrltsaisssep,locroendtaiinnst4hae sstpupdeyn,dixodENtThepTreesbseiaitss The valor quality daca collacted during the test. -- vi moamo ms n mast sunsmance: BBoatvtiloesy1att0hea0nts)vasonL(uTJbauevmliuiraeocdsyysvitte3h3n:,sth19Se9u0fp,ollsloItviWnvsgabseIrncdoonrtBmaOaiItnie)odn:inwaGeiase5al0-0i1v.ael~rpFalEda-s1t0i0tc3o TBTulaaasnetyraitaotttousnr.'e. 1iqAPuriieor)resecwroavneusessuuptmphpleileetdes(btsypmpaIrtNoerrCiioaamalptaenlwyya,s13s3gt5roarnBe)udshviniAlvltehnebueeS,aurkScth.iitvePadcuoloa,tn Tavitobyatens for a wininua of 10 Years: rp 3 tentingVatweraa Siape." ucseodllecftored witer is aLfcrcoliinnsftweilolns.to"o)f atsteasrtEioovariegcnuosntiyssontsesTsasdianforTuaublpltCotnio,xeicNiUetnvyd hSfeoanrlfaectnTtGaal5y00s-igskiloonf poTalyertehpyrlaesneeatatatnikvse, sshaasrpeieLtofvawsataeerrataerde. reRseesautletds oaf pp Saest k 5 sSo2u0rce1ao""euvieTdhset"laec"etedsatp4hea`nvietdries.EieeLdsepslusorriTenhdganas3s0ahptopeurseotspei1aodtregu1sfiasstmohsesonvsietcraocftkeryoo.fntD8hisephltneoisdtgs. l e CANEHUEIEET5E y, CGThceiyeueaincoen porTifoetructehde ttaroonmnailcaityf1arh0toeussmte, culetPounectlereorlthadtoto.bvaatiseesntaiinvaget,raeinwieedidgvhaeedderafveeBrthe | si 7ISEE Fs SSunraye,r3redd"Durioanrg10p0aa8crcealnlittm.uattiioosnnicuhwaapsthseoarl,dusndienvrjeurresiteoastt,ictcbroheniadtietdbioofrnoasrnlLdioiste4iaesisete1rn`adtcltathshesey'(C15i0 || TFRRBIAEALE BTELEtaLgltaraGianniUiiynNbegcfhooroweTf,aitehetaihniedttieosntttehsetth.ettreebsmumpeeeiarstaegtrurtehesvioaanccl1iS3so.al0to%im.osnstpDreisrpsiboadicaas3p4rvihacozouerrsa sfuetpderniycoeuosnttcoe [4501 | | gE 4 ei es a i Ra 5 Sai LToHAgEe Maevisrrosoyarte3ns8Study Number 5013-3 id FEPSGr A y ak SpSSEGaLEIrG RD PRERRRARTeElAREe3Ri LCUERUeeEeet ERe S rR k ee AD ones li Sher TR A Eh eo a 03920 3 cris Fl me gl 3 Table 1: atin wl TE dda rR Chemical characterization of a repressatative sample of -- "Parameter Conuctiviey sarteens oSramemocenirtae TmUenaibe tveaonfent t ReUpToartEing -- mie - wonton - wa sgn os Neaiaisuwered % 0 0a w - =; froren Orgasophosphorus a 0.5 Lge os 52 IPoolychlortastes wr os 5 wo He in SRR ok ST ethnee ETT S : & "Mot detected above the reporting limit. STEER oka 3 iad Cs ES ReNE Lig E> J3 Hoo SE Ee Ce oa vnre g ip cronies ES HEIRR ] I3 TSE US RE SR RN ae Se N EENEEeRAe = hid L5E glen eee CTAORRe coSdE LamebueaassEoa nE : CE 2 R RE bmR atlRSEERRE 3 SJealmdeenl nLo athanni niaap inin Amn SARS GREET Eh 603921 | roster aston: "rGo3beuaReTyA L$sc7rR2ee0nli7ng105t3em0sa,tT, RviSot0nh0 iRntahce,ontcaeemtntrs1ad.t6ni0to8anssRcaeorvtseAkcCosnEdbuec4thteendhcoedvuecwianr5ge Cr EronttT e UhrCeacaatseat6i0onisc.rivel At 1100 Hark ood 1000 serivel ak 41k 1P 6, 193T0h;e dAR ectoiraatitnigve totI oxaicriittyostpaesrttenvsE a TpuacttoraPerdor todcrolag30r1e3rura(esykae3t7e,- sSieoniesruSsUofEtnSotu)y iesnhcu:er on" rebary Cr A309 in busedon HforeatcoTcokentestoneltsutitioonnvsasvoacfnonpturteeorttpe.udedantb8satutbecasetrsmaantedmcpi3uedrlaitlvuatrsiecanobfwd3a0tesr2rec1co9tnltywoilttho SSThoabTuratRnit)ees,a1t5"e0rnmaaCdro,aiCSo5n0ceudmstarTaati4oh0ne0"smaotrfskh0a0eentlhes,st amna"dvtieer1bi.oa0ulr90vtehmreeo:su0 5s/h3 : BCeotshleircssTuenetahattyot cd"oaSnitsna.hinaeLdeveer0se0a.ncu.4s1doTnloToypf e12"r8ttesuvanlselpfyuhrcdifioosnrtarditbuietnerd390sdasea1pnthglfuowssaees ike . SsaeEoiEpnLreEctRrEtGmEa"tthae"l"ByiTrtoSatgtCo"HnThe of! h"cheaocuhr vLreeenrsttseetflss.iaocd4ee6nhomcuaornatrAoi.nsshtaa4brl4eeunveeeghsovuereiddnart1ko0 Foeidd BHwhaIoiGtcHphuortledFaauvla"isehdavottoonsatSiaciaaTltiiikiyen av"Hiilnsatstaoeilasvieetddy wSoie6tvhg0t5ncoociuornmwcihecnaete,rant{iloenersreasstchiaoonrnte CARL Lilet Theis: paetis vere not fd during the ter i THPOEEeNYEisTitututobiidoiTnzoaticonhrabo(etirhneurbiolfimtbylmeettvhoi.avlisovgsinitowreigttmhiimnonst1s5oodfsescoetnhudeisiboracifcotuner,rrenecrgereaattoiifec) SIGiT abliatn waetrhe "GaevecreeifnleedxviescetitluybiaistdtyF,acoardceestotrasttiiaotnl,y oarndcahfetgeer 1Fs YSEIT a A GELELoe aBe4soiH 4r8edhoourrsi.ene DTasTd taesdtelorgy a5n7ismmsetevresrs irenssceerreerdnenvthenmbLairratHcbLasSrvedp.hi iCGE SFi RHEEEhTrlabaeions aWBlShTlstaetteirr,, alanmsttrsSumhteasneterrstahbaaetbrceorTnAtLa101i00n) dvveerenspnaasraeaittseug,reedT(foa5st TgH3 e SHiEkEeLs marisa,woos: Ce sie TRIEGS B EA = Cpi isus tarainldiatseuLie euotkrRuitioenhoessatf(hSaotndutsihvaatrsy,"1wt9ees6dt)b.H vyeTrtoehe'e psfrvontbohiTotrt, tesos ocrixsipybcuylvrutetaaertiestnhodoe`a3erodar AURSHELE ee Ee Leal EE BfPEREresES.=erarviVurmo>snoyratei1n0csil nS5tSudRy NusL bNerT r9013-R3SAY SViAS L Ree cpsSifrs, e4 SA SSE E . 03927 Ee RE PESTM. . ae iz. mess ; LOSE aAmpNpEaeDrtAeLspAoP nribieirstebeorTatCinatn, ettt,iheoelSotGeSshpoehhmtettaitssctdahHruohpel|oorpaTt,leEonnettrBlernskemiewaei)oanttesaoriol onmberdsreedhlh itoslctliotsnshdee = JL cGteoetrmaiceelnllotyte "t"SaL0to0n0cvaaastgsepEparioaxnttahdseutdael"utynydl0.wo0f1i0lth5ees.tersotnEssiipeoeLadorne1iasogf 0STaesbboodisudteiIobSgoOts0hhee i 33 %g/L, and seesenteTde a Taon4la8e0ho2.ur08"EoCko50uirhofno11u65r0m0kgc/Lf.or dugTbtnidasrtempFoarvteodnst:o TE-iond are Jfa ha x iE 7 i ai3 ign a B B2RC m RniEb S Je BEE a iEET es z iA a aSi h Ae t hA e i CR : nSeafee ebea a i fos TEE amCRNaavtA cosrsudyyE wsestbese30n13s-e 31 rLia ane SR SitR s GEERIU RE and S A EE s A fi haa AN a oa BE 4 SERRE A HR Pk i RR SEER 93923 RR RAS Re THB 3, Suentead dua trem totetty tot -_-- Y, --croon--nW ctma--mnittwion . D_o_hwnMuwbWsaeadwritrAGe iwkwn Gew[ reeber rMa-- teetw sa ; Sls -- PP1 ooosross s8or r d3r sss o8sos 150 o PPTooos ossr FFsfrEsr s8oeoee 0 PiFE ooss os Ff1 Erfsseeee wo PPToooossr Fsrs fF 8o8ses tot wo c1P1o-oos8br 5fxr4rgswboS s optgi ar gd a1 spt 1,000 FLrA as D1 oon5dass dasd ni0. nTee ThyesboddA gLiest siae So BERR l edS eTentfee CLaRANE Rote aii seecocnrdestactireornoiuenstlve aegriteT atione) iTA e 1s se ; pe be ho Ag| Bian A fon. EE BE fan hl Eph oy a i ARE iE GSA E( S ESSd EES rair cabnnteS de sR EsaySoasS i is 901353 P S gBeAa tE A a e R An EE reRa nno i ini e EHR|)SSde HEEL apn Fo el tReTi 03924 e Ss et e Sai 7 Toe 3. dln atutine conotrtion (EH) tron Soe tot | 5hy Hperiiodd wd Wher _-- I230 coenftiieelmecsnbtaiatns Wvaee d" SioR Satie | ~ ay San 0 Low sootieer Daterselstion ae =H i re SaarlR da Sid] 3 H So a aale Tpeelican ThebaaEybn DEERE Shee TABLA ; fi : E Eee EY > 4 a PF ERT MU IRR SET SN TEs ais ZSER Br Sn Se AE E EERIE R eI R R S He 5 as Sebi slimeI us. sisi isi "R1E5603925 ox. mms BoBEmeES.at1e0n1E9mh0acAkDiubceetstteoan aofofthDeecrnoieaeste.Cehurensia3s(tOhekMuPteacthsBeiseusptoafncfeooodf GBMeaontt.iaciecst1lr9ee0.eTo.iG,ulatHlhoianuiesafiooxrrTiepsPtayeno"fhChnieeie.mlesstnii3e: EoTcettskon suman, SCnhi19t0..Comte pogean for_ caleshtion of 450 elves. Fe i Gala SSEESRES G IR bcc REE IRE ! WeXe i TRL AR ng . a SR RNRE EEIe Sonn ada. Le Se LE ee T E ve MEER Pa A C Fe r TiE ai se be RE RNC Sl oval a Lees aan wm e Ga Ee ERCe HaEeRErmavi recayant ens Study SabEer. E90e13- SEe EPSLRe BSIBIIOLE 10 SSSGE | ERR Red HL LRU | C3926 R Ey E oR Ea R Freeinepa i gon iBh Nhide tk. : BSahii S SBRoEA au eaEit iRt Siu Linas La E en T oE R R A hs a 3 ARETian : S 3he. Sa easCoE EERIO OT C E =n aie B&eL eb dh nl aoes BOa R BIE al DHAERRR E S EaAd Ci taA ag a ag er 03927 TY Tab h.1. CConEtuEctiRitIy, LoB, mtemaratre, an Sissies oxvn --_---- C a conNE eonntnriation we TEwW LB WwE W vtRiR w Htw Ro , Slemrod 1 me we wo ea ea ea PCoOoRmoom moe omm ooo do Houou 10 PLPooommmomwe omwm ei a oaoma wea 0 P Loo m mme oowmouwamonaa eoau " CORE mas CALadomeiewtienn Sw aEREea ddd BoB 4aa3 Ldads CUO mogmElee US LE Lo aepE aLi0e 0es0. E dR EEyE T aHsE oeen L(Li e e vRon 4 Me n e ao voMiR MRe ewuev8e T .a3H CaA een 8.s3 = B CE lR ea n aE FN ad I Ta BeABT ER SN BTlloTheMeFRcdE LEnYe al en i SRR Sot B AGC bbEa e Ti ign atnm ehLRNyEOa maEstei lEitRe e RiCb eE dene E sae aiE eBaeR gy N stad Rpm : ; 03928 S avaA itRCAS A S E RR REANrLeh LL Continan, rwr ra onun test nm w ea tdors 7 (control) = TCPPr oOoB2RE0.DD1 OEE2OD0SE.D0 1OoO9B.BmI5 I 9o3.n5 9op.n5io9oBa.ae0 cFPoOEwEDEboRODBS PPooBED me BBoonaoon ws as om on - CPooEDmbOOoESEREEOM PPooEmD Eme Sws Om on a, ooopHmm 0 ooooHHno - DPDCoOBooREoBEDELBmBEeSIcLouemEmmBss-ooaynna,BHmoooMnm ; 100 " oEbUERAE 20 avian .1 ooHm foopEgrIBm20eE .0 m7 nanAEinEaaL2n1Sy9.3 [X1 : ASS E a See GedERis Hahes a Bi > ; wrem Treeyal TeaE se Np ZETNEERPEa RE Tv1e on 2E : parteO RsEo stu L ubi e voe s5E 12 HGe b ee E 0 eOeLG Re ee 652929 Re 3 FRET Shebeiso an Envirosyateas stuty nusper9013-3 3 RESECHshsos,oncoonronarey we TL RPIEE tstesrasronssoerny SatiA e uteeoseateyaennvi 8pans - selrShpconeosio,rn E smn tres B0 a Ron se ahi Sl TS E E teat Eroryatens, Ine. ii Te CER ah et r meted Fie {ob a is a eee i C ri e mSha as L io ty mmnoll SSHaEsL AERA vee Fa ESOSeGs irnen fine Ca fff 5 ain le Fo sie Sion R0TS eC: hitsremEyoree,LLt mEEEeELsRTe ay X Ph fCm7aR ARgieaas L LAaT S daER 1 iSriiine s dn Ls ey sass eaA i sibl EL Reesi C0339 iebyn 1 tre Se nme ewe ety Tu E00) od Te ie, nts 28 ren TTa oa tSraHit nEtheL34 bods 1de0ehou aanftteeestoaothhnaecootnccern (o13saem 20 Test ome, 3S.p3iTehde Sar, I ein test substance and related stability nt se nd purity udatss vivilnl be ErtHe dSeHElRat att grifl nStSenntfborreesIeEp,Stweiten BEI Sint Send ld eae ot a SG3htJettiiaitoionnn gofTGultr siess oy al be sci seis ivyid vn ree Taal en % FET WA EL PTUaL eee : hg FEA VAN aa AL ClREablB e a S S R LLRE ee CLaSU RouseArch.be.Sicko ofMLPORE 3 03931 Lulii aS L r RESERTR SSalR Eorirosiatens stndy fuzber 901003 TEAfaTLrriptebrahtteoer tngtdlooIisinenitDiiutabvhteaolraa sBadcafauatlttaiutsneasofepuenatterhdsTatate6 BoartseTpAacSemIcsontnLdciotcietcoionhnss - iSt preitotreiteonTs eCnredperatire, reHseciwsieise,baansdkipononreapdrifnodsgotrioon npadte SaEt 6.0 ExrosuRE comorrions = *Sii1l1 Dbe"uraehmd onlTyILat HSee Sceopnidauccttaegd SunTteRr sNtaaCttiec SSoam3ra2ble0cownacteenrtearwiioln)s beornaptunrtelderdgerout conttion, water. 16 and wild fest Si meats be teen of : RTspEeRehEtt,ingpL.ate1ear r2U00aSCEhescdaulley,ch"usraelcttyirievdenneihreSuhSnasonuBseareisehenhSarst oIcLyhCeouat0t01s0 iia 6-3 Vater temperature will be 20 3 goc. s5,i4tucsDtiisosno.lveAderatiooxnygvenin t$1i57o1 nEimIe FShetota S#o1hbe cSoorncmeanttEraAttiioRne, will be maintained sutonsttcatly conteetied ant dsustd BE above 70v to 16 sours ? SSe.hr6rneeTphreCeodniteti,enstteLaotvireosdnss?elssatweilwlilb]eL2e50aamj1us9tleadssvoBeeahkseerrsa tThaatucoonntiainn 220000amlootf i g 7.0 sine comer Tika To", 00 3 nee hating evstionion adr sevion sareeS1Sn)s "Sleenhstrtia.rh IHThe aseeeerssastnEmgmaeedn,tfpindineg teslt is Scm ondRuctLn ed. AC nit ealsL vh ill besexaposredstetleovseasAWE0 FR 1 SFSTurimtetR ap,et, nfhe,cdmefeTitnthiettitveeionnutsetststeitdhMos u2 nwiaLsEv s SLbiob [expdoa seeds1etrp y45)e I nup wtresSAg H= aEalSE hTainhtilcAipateLdatL,CSO EFliSte, 2Ta 0anedsBonCitSaOln.iesphoe vesli ss i xeSrckiag re t enes otS ek Lewl IaSC A niR3 emEeOno A AoEurSn EURARE.E || nJ Se e eanenifiovxniehobletspe1tcehe%nsn)SvoanoacSotenrmiTiaRsnerEseovte,i vFeitAsEE || || hon Py oi sot 6 U FARLiea E a CsPETe h eed San Re golid Re fEeE a CNe s R S SOcNhSEad a 5FH1RaEC03932 rE - #h ey sp Ad SEI RR en A RE A Bo STs The Mahest Evrsszpasn Sty tuser tasted concentration vit be 1 gi. 010) 7h:6,aJolie nt sbstasces vil} de tested 2 completely Eitied ant 77 hA,e SomEelTty dtitarshiolod sineeebuccoosntuctd wih 4 utarnce onteunt wST[iiEhuIBLrtTtoeolIvdcRnrgheRnh cToE nhciomeotstiooC nr, fpen, staBemIreEreaRetuee,aandRconC uctiity B Raoneetervals "T eins a nt Seta m nen m AR Td-- reer ae 20 7.10 00a Anaaats ad Sesioticat rset E TahrepeSt TT this, en h-- ehn nn-- aerate lTtOG pIet ntdoxicity accus the shove af the done-cespone curve +0 au assume ar quay coma, 11 ToBfh0e3oSernetCeSEnC1Etor1ImoDmbEoesNlcoenFsputFvieendaSl1i1TanuntteSotfhieeheetnhdeefoofSetleatohnneSiencescbtoned5i3rtieonnnss ecouners3d00, BFELESPORTCemciHtucRe fnIamy Htes vessedFis sitd)of the une of 3Sh2e,m0,Ses v1 be conucto according to 563 God abertory racic w$iih Bh 12, SrI ACien Vhusen s of ithe enst ctoneucted at Resocen ntysts Te. ax| L a 2oH .54,, tSheeE l iSntJuadyGS A DaisreYncthortsvS eiL lalHnbeirdRespan oL nsBiHbleTeforrccovicelviingaaS 1e dfartal'4seda.tiT otr A HAEE ie par vor Ee 2 : LTE RE =SFBaEavnEena h hoe oh SPngRrEhS e ERhi E G ooR e in e STCRtEorEeEsoHnSicii TE P ARPRT E BeREEtN CT ea) ni Ta 03933: Ree A Eaicesyatess Sty tasber 901303 Sa.0 mSf5o:E1EnrecttToirss ndor rigattbaEae El Spaatrtcsomcvitlelid tbhee tbpriacspreadnd ster reviewof a date Brepted ihe Hosts beh 9.2 The taud roert vi2 connie of at Jeet the following Intormtions 9.30 TT mEenph age, a includid ng the sStuhdy tiR tle, dateE requlrensat,' id 3.3.3 spemmor-supplist contideatiality clatas. o 5.23 oot Gvoratory Practice statement. 5.2.4 corkitofiGcooadLtaboiraotorny Practices. 225 Table of Contents. 5: io 9.2.6 Susaary of test procedures snd results. Jo 5.08 mettods unt materials, tacisttos + description of test ER, NA ieEe IA J -y 7 5S.2a10 RSdetfieerceentecensv.inaScehntaisoenes1ti1he aamtpe,r uti Ene udFa Rhd eeene Ae0 a GRD. 3988. obo" Cudetiass fox Testing ofChenieilhsuction 3:BetactsC5 84 Reproduction Test. Adoptea d 4 April 1e9e84e } Bmin Sit DCEARAT LfTaa nmaa R rd a e pa in arnaiR cse sTianeiT anSetmoen,hetCHTehs E eBE Hi es7 GGaubmudadiineoensa;{Aaasiandtounsainttsea.r.nrFreeaddeturcealtSRaemeaglistteTeaerx,iSsnViesdnunbeasdstdeaasrye,,esNoCaroyn3t2r0,o,r11A99c097t7toartR HSAOANGYE rns eltaie Ube SeRg S c Sl he Tah oeRe E SaE ge aL on E AGEaRn i SEE Jaen ar E aFrdE atn es ESER R EEof CeOR eNA B ER S e SOESES,k: ARE 88934 Ea Ee fis ik i Soman or ras aoortions fTAocorcneopSabtieens:paces: Ssuehptantessusne i AMFfseoeretriaianno)t TToentleo!xsun-tons fBireri ri-- crers Bem of Smee: Tent Verh vetoes Lranitzin!g rate: Hi usar: Spa3evyfnoieueirescsLioLno/t8TBaonur2s4ptarokus ota Hieh : no dur me eta ten 1oF2 oHtntag Exposure Bett: msebittration 3 Acceptable Teperature Range SEA inp he Caen 20 gril 45% Si ARE T om; raSpa s y 3 rEoo RE i Git eee : 3SRLvr. 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