Document kDrrpXnRy2EQN4voGQV13o7En

o'V m?QU)i."T to mo into company KOti (.'NAiiTir/ 01'' I'UODIiCT /] cCoOwNTAINING TO!,\'CiU.Oi'\INAT12D liXi'illiiiY{" i'CJlI" ) 1. Nome anil address of. orfjani sail on making request: ^Dr. H. Ernest Hemphill, Department of Biology Biological ReseardiLaboratorles, Syracuse University 130 College Place, Syracuse, New York 13210 2. l'CB product requested: Archlor I25ii________________________________ __ .3 Quantity requested: 50 -lOOPml II inters 7), Reason for request: Archlor 125k Is the chemical of choice for inducing liver mixed function oxidases in animals (Ames et-ai., 1975- Mutation Res. 31:3k7).We are ietting-up the Ames system for screening chemicals for potential carcinogenicity this technique requires mixed function oxidases from animals to activate certain chemicals In the test. ' 5. Use to which sample of PCB-contalnlng product will be put: The Archlor 125*i is to be 'injected Into' rats to stimulate liver mixed function oxidases as noted in W above. Livers are then removed from rats and a crude 1Iver homogenate made as described In the Ames reference given In (k) above. 6. Disposition to be made of any unused portion of sample: Toxic chemical wastes from the Dept, of Biology are transferred to the Dept, of . Chemistry which has a contract for final disposal by incineration or burial. MONS 096317 -2- .7 Names and brief description of educational background and Jc'o responsibility of pcroon(s) who will be working with sample: The Archlor 1251! will be used directly by Dr. H: Ernest Hemphill, Associate Professor of Microbial Genetics, in the "Ames" test for carcinogens. Dr. Hemphill's educational background is in chemistry (B.S.) and microbiologylPh.D.) The undersigned organization represents that: the foregoing state ments are true; it understands that if Monsanto elects to supply the requested sample of a PCB-containlng product, Monsanto does so in reliance on the truth and accuracy of the foregoing statements; the porson(s) designated by the undersigned organization who will lie working with the sample is (are) aware that PCBs have been Identified a3 a potential hazard to the environment and that regulations concerning their use or disposition are contemplated or may exist; that the label accompanying any sample will be read and cautions and instructions thereon will be observed; and that care is required in the disposition of I'CB-conlalnlng products no ' us to avoid any adverse effect on human health and the environment. NAMii OF ORGANIZATION: Syracuse University Title Associate Professor of Microbial Genetics Date Fphrnarv T. 1976 MONS 096318