Document kDmQY4OjnDd03bOdG3qZXYY0J
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E . I. du Po n t de N em o u r s & C o m p a n y
IN C hPO B*TC D
W i l m in g t o n , D e l a w a r e 19898
POLYMER PRODUCTS DEPARTMENT
EXPERIM EN TAL S U T lO N
PERSONAL AND CONFIDENTIAL
cc: A.
J.Dahl -
353
B. W. Karrh - N11400
L. J. Papa - 269
PRAL FILE
l.C.
>4#-22ir /S'S'b
July 13, 1981
DR. R. LAUREYSSENS F&F MECHELEN, BELGIUM
ANALY5IS OF BLOOD SAMPLES FOR PERFLUOROOCTANOATE (Job No. 311-700; PRAL Nos. 81-2332 to 2392; Notebook Nos. E225IA.E26238)
As requested in your letter of 5/26/81 to L. J. Papa, the 11 blood samples submitted then have been analyzed for perfluorooctanoate (Cg). Results and sample identification are given in the attached table.
As noted there, the analyses were done using a gas chromatographic method specific for Cg (Lab Method Number ES-567) but results have been reported as ppm F for comparison with total organic fluorine analyses. Precision is + 105? relative standard deviation over most of the concentration range, somewhat less at the lowest values. The lower limit for quantitation is 0.007 ppm F (0.01 ppm perfluorooctanoic acid) , with a detection limit of 'v 0.004 ppm which can be distinguished from the reagent background but not well quantitated.
Please contact me (772-4440) or L. J. Papa (772-2745) if you have any questions regarding the analyses. General questions on blood sampling can be directed to J. V. Raines or L. F. Percival.
Attachment jah
Key Words: Perfluorooctanoic Acid Perfluorooctanoate Blood Analysis GC
S. S. Stafford
000092
EXP000028
EID713842
> TABLE X CONCENT RAT,ION OF _T J-^yy^pM ^C JA S O kT E ^ J H BLOOD (a)
Sample__ P R A f h Q Date Sampled
Sl-2382
5/22/31
81-2383
5/22/31
31-2334
5/25/81
SI-2385
5/25/31
81-2386
5/25/81
31-2337
5/23/SI
81-2338
5/25/81
81-2389
5/25/31
31-2390
5/25/81
31-2391 81-2392
5/25/81 5/25/81
P.R.No
1457 0941 094 2 0585 1352 0085 0697 0479 0405 0060 0325
Name
GC Analysis Date Analyzed
1 6/8/81 1 6/8/81 I 6/8/81 1 6/8/81 I 6/8/81 1 6/9/81 I 6/9/81 1 6/9/81 1 6/9/81 I 6/9/31 1 6/9/81
A
o o
_[C_b ! < .007 n .d. 0.008 0.11 0.16 0.011 0.0L3 n.d. n.d.
n.d .
(a) Analysis as described in Lab Method ES-567 ("Determination of Perfluorooctanoic Acid in Blood, Gas Chromatographic Method", S. Stafford, 4/3/81), using the packed column GC analysis with perfluoro-n-octanoic acid as calibration standard.
(b) Although the analysis is specifically for perfluorooctanoate (acid or salts), concentrations are given in ppm fluorine for comparison with the results of totaL organic fluorine analyses. (ppm F = 0.688 x ppm perfluorooctanoic acid) Estimated uncertainty is + 10% relative standard deviation. The lower limit for quantitation is 0.007 qgF/g. The detection limit is 'v 0.004 UgF/g, but concentrations in that range cannot be well quantitated and are reported as < 0.007. hone detected (n.d.) is reported for samples with fCg] < 0.0C4 ppm., which cannot be distinguished from reagent background.
*REDACTED*
000093
EXP000029
EID713843
