Document kDjwo6y80pG3KO27Gz7gkRqLD

April 16, 1966 Nr. Robert Handelman Project Engineering Department Plant No. 1 Ooodyear Tire and Rubber Company Akron, Ohio Dear Nr. Handeloani Nr. Niohola has asked ms to Poniard toxicity and safe handling information relative to Theraiaol ra-1. la appropriate animal taotiolty atudies, the rat oral U)so Cor thia product has been found to be approximately 0650 n&Ag of body weight. When applied to the unbroken akin or rabbita, the lethal doee la approximately 1,000 mg/kg. We believe theee data indicate that Thereinol FR-l la not particularly tootle if accidentally lngeeted. On the other hand, it is moderately toxla if there la pro longed and repeated akin contact. Animals survive single 6-hour exposures to atmospheres saturated with vapors at ambient temperature. When the product is heated to increase volatilization, vapor concen tration may cause aystemlo effeeta and death in animals depending on the temperature and duration of exposures. At vapor concentrations which are hazardous to humane after a short period, there will be immediate transient symptoms of irritation, poaaibly followed by nausea and headache if the exposure is continued. No serious acute detrimental effects on personnel would be expected during the normal handling and recommended use of this fluid. This includes pouring or pumping the fluid from original containers to heat transfer systems at ambient temperatures. When used in a properly designed system, there should bo no leaks or opportunity for escape of vapors at elevated temperatures. The only opening from MONS 090365 Hr. Robert Handel--n Page 2 4/16/55 the system to the atmosphere should be from the "hold" or reservoir tank, and obviously this should be vented to the outdoor atmosphere rather than Mlthin any building. In summary, we oonelude that the danger of aeute short term exposures to personnel la not as great aa that ahleh involves the possibility of syatemlo injury resulting from day-in and day-out chronic exposures - either by vapor inhalation or continuous skin exposure. Repeated and prolonged skin exposure may also result in drying and crack ing of the akin because of the solvent action of the If the above information does not answer your questions or if you believe I can be of any additional assistance, please let me know. Very truly yours. , (<0 BJatlmJb R. Bnaet Kelly, m.d. Medical Director cct M. Nichols - Cleveland HONS 090366