Document kDeYOd5N9Xv263dB5Qpk6b76B

PLAINTIFFS EXHIBIT DUP-157 o-m cc: V. H. Branan, ?ID, X-6537 Z. S. Clary E. I. ou Pont oe Nemours & Company Wilmington. Delaware i99S CXNTRAL PC3tAPCH'OeF*TMtJr ana Development HASKELL LABORATORY TOXICOLOOY AND INDUSTRIAL MEDtCINI ,JUH 6 197S J. W. ADAMS ENGINEEED1*3 DEPT. L-33V51 ASBESTOS FIBER II? "CCD GRADS ADIPIC ACID Raft. : Letter, Z. *. Adas to Z. T. Reinhardt, 5/2/71 Letter, V. M. Branen Co C. ?. Reinhardt, 6/4/73 la the first refcreaca letter, some quantitative aspects of Che use of asbestos gaskets in fluid bed coolers employed la the pro duction of adipic acid are described. The small area of gasket la potential,contact with the acid (525 sq. la.) and the large processing rate (35,000-50,000 pounds per hour) of the acid Itself have led you to the conservative asstaopclon chat the resulting product could con tain 2 ppo asbestos. Based upon the dace submitted, I do not believe the potentiel presence of such e email amount of eebeecoa in the adipic acid preeencs a toxicological problem. Vhen the portal of entry of asbestos lr.to Che body is the lungs, a toxicological problem haa been demonstrated. -- A recant publication by P. Grosa at al. [Archives of Environmental Health 29 341 (1974)) indicated chat Che ingestion by cats of a diet containing as much as 5Z asbestos over moec of their life did not produce cancer. This, in addition to ocher similar experiments reported in the same article, indicetee chat Ingested mineral flbare, including asbeecoe, do not present the hazard chat haa been associated with Che inhalation of ease mineral fibers. __ However, since you state chat Che theoretical 2 ppm level at asbeecoe in the adipic acid may in reality be on the high side, it say be prudent to obtain analytical data on Che exact amount of HS/ms ORAL TOXICOLOGY SECTION DUP 0903570 atTTC* TMINOI *0* CTTt UVINC , . . ruMOKlQH CH*M*5T#ir