Document kD2KkYYqdxxL922oLJvrzpQYE

AR226-01 ) A ` ; , A i) i SER --_---- seT ats sea e ren ed ofa 12 48 aToAountaho5rs.svtrs spt--cnt--sst [cfPoeorfnoirepnnirngsa--Lmaldvoera--atteory s Ba A se ote sty vas snc BEST COPY AVA: RRR ER =: SB E : SH: 8 ooteo7 PA ------------ m wen R LE n This study vas conducted according nLnhRrLsEER to OECD Good Laboratory Practice N 3. stRSl eile sore ViotlattlZB 30000 . J e FaA gMl LT 32291 f Je2hlipi enddzSeitas ; legagses. su BB Sfp Coty Ate ied = y ARAT> E i 41 REB TRE oh Ed FE ; Lx ER bi BEEN 001605 I. gory assmanc srr ) Submitted br: PTEoeovsiocuoraseeyssat0AemnssiradtisvsisiIonncorporated Faetsatont, hior Tfaoasptiice 032 cortitication: T2[35h0tesetPeprnrotderusacestagteRaderasfdsoatreattaehtdiisaodnsreaApcocwrotrpedavagenrcTeeensdiieeersnilovEneyad,vibLryauesmbygeastdttheoesdrsePeaSonvtdeosebvsaidrtthe SNSaTtLpeLsd eSira2t0osd TdTFraAratGonakceEeniL,uTacedePsyattoiAearSulAoIwv.aelpaoTrnheit,wTioR1ro1ibeeblrettsaBbroochenirvveedssopaatesTtiRoaerosmtoemhdircbeByeaErmhdillornaTcSoeee,msiTeeareie sheanricn8otv S HsIcIcucEduactya, atNnrdana4s1c1ridbaetderfvreormeevtehreifriaers baytaQultiotythAessroerpaosrcte Jvoebristorcsh:eckGeudrlifcoyr odby avaLABLE binteset Tuipmoas Tatra sDteupdoyrDtierdecttoor mWeoawm Sarin BRuespaogretneedntto wSYiramaaimmn Tiara [SSh inegeprBh eeca rk 3oy20.0 TBavriceossyatens stuty Mader 301713 a rv.Soran E Pog i BESTCOPY AVAILABLE I V. Summary 6 sn 001610 ov. Dom or meus Page THe 1. wCshaaetamepirlceafloofrctshaoatxruiarccait]teyrwieztlaelsttiownateofr saeerdeprssesdeinltoattiiovne . Tisble 2. Survival data tron toxicity test n Tibble 3. Wtertoniantoexfifcietcytivteestconcentrations (CSOs) n Tabblo AL. Cooxnydguecnticvointcye,ntr38a,tiotnemapeersastsurreed,duarnidogdistsooxlivceidty 1 S EPansagveiza5syosfte1n7s Study Nuaber 0171-3 1 Tile Cot v. soar D4e0cetshibseTrhfe1i8naactluotre2e0pt,oorx1ti9.c9i0t,TyhaetofttehFseNtF3vo8av2si0rcotosonydatuthceetnesddaDpfihovariisd3,iNonDCaoosmfhpoaRlnesysomufarocmfea4,8Anhitosiuyrdssteas,cdruirTbiocen.dg dPieentveeBral"soppKteoodwna,flosrNkeiwF,avfaiRaropobssebryitsctee.BnoserSIitt,ovdayasuNdcaobTneidrauocttSheOyd1TIbV-yaDrTdileasccSotradnifoogrd,fo Jefahseme pRraotgoacreul, dtielsuttisoTunhbesvttaatenescrte vsaosd vas perdfiolrunteidonunvdaetrerstcaotnitcrcoolndaittiaontsemvpietrhatfuirvee filtered natural well vater collected ron ocfon2c0en+tratCi.onsThofe wells st Baapton, Nceown.ceHnatmrpasthiiornes. abovAeeraatnionaccveapstabnloet leemvpello.yed Notsoioialsisctosnicsentdriastsioolnvsedoforyteesetn Gsu/bLs.tancNeomivnearle:c0onncge/nLtra(tcioonntsrolv)e,re3u5segd/Lf,or40allmg/cLa,lcu0latmigo/Ln.s.100 ng/L, and 150 Tess thDaanpb2a4idhsouurssedolid atthethteesSttavretrsofprtohdeucteedst.frosAl1taerfa4-8bhoouuseescuolfteuxrpeoswuardewetrhee cibnoengtiarnonllionagddaiognfbgnitdrhsaetsehtiudodfya.n0.a0~v0Te2xrpagogs/euLr.veetofAwLdeLaigpdhhatapihd(asbildotsottvteehdreedrtyei)astogfsouo0bd.s0tc0ao0nn1cdeigt.rieosrnuelstauteldtitnhigen Co4n8tihdoeunrceweddaitaenrvaelffeocfti4v3e=co5n6cewnatlir.ation (BCS) of 49 mg/L TN 3820, with a 35% EPaavgiec'ossyosfte1n7s Study Member 50171) ec vm LACES : EA ve ) aSnRtAPLel taIYt aDSLrItTD-- n0ce mEspR,ee 3. elel,tHMrseSsse rTfeoiote mr meme vr. ree se are HSAoRmI 3Re00 aLrcot,rtosTLdsoepnmtEeiBnea,ner 3Ss2906,017)p0anhpA OreiinetebsmeStisEloliteecsBrrtLens sr nares meeE wS e ELRTAIR iinmatret ealy ae wH--eR a S a--te sE moteLtR emaba eanmt icetnlo,rsfeticmd3 sioercec 8 T R E nA yaL R.eL S TL o S SS OT Le mT eaSTdS LS TdeeUh e anSLaa, S13Rtny Se0mdeeteli te eFAdRSrAEEerraat tinsdeSoni orcas sitymass 313 BEST COPY AVAILABLE Te re Samy re teCAn -- VE -- = | it - | Conductivity ushos/ca - 1200 | pniisste wan , - | prs " - i rons wn o - | TE R T E Estie e ma,JB E uateTE E grLrhLee rsk Sane FR JJEST COP router TesTin: 1f8o2.7,1,A1090s30c0r.ReaenHfienngiAntfietsetrCov4ni8ctehhnottuehruestitooefnssteoxsfpuobsLsuetrsaetncsteuhbevsratesesvcceoesndsOuevcrtes:eudrOvdihuvrailn1ga.0t,Dec3e0n.be1r00,5 L100 wai 600 survival a 100 ag and 308 oF Srester survival at 411 atber aVDEciCcrhoercdtTTioHonreg3od8nteo0tNioTnAvaiuevtdaiibrvTeoehrSeyta1o6Dtn,eioncps1ie3t9dyT0e,,sttesDt1Pa0rpvoha1tnssoicapboeulscsateSgodOarIsa0T)e6I,d-p)dsruhorLc(icSeothdgautrviDeacess,ceosndfidegaettnrehe.et18TObo0tyxCoiDtc2hi0(et,1y981s0T3t)e8o.r0dk,y cSEooncckenTtshroealtutiteoisnotsn ovvfaasstrecesotpnudscuuecbtdsetdbaynactceom4sbnidtnair+nggedt1i.l0tuetmi3poenorfastafuberseetr socufobnst2tr0oalnsc+e1wA%ith1w,0id0ih0lutatigiorvnie "SRaoItlLen.renti45ndmNaaordukjl,uuss6tl0incwgoanrctthe,ent1rf0a0itiaaornksc,oonfcaentndhter1at5te0isotmnoasatheoeTr1Hi,a0Il0I0Dve.ar1e:wi0tshogult (tcheonturseo):of253 SSE00eaMc1ThoefLsrteeyastdtaaupasbkon.liudtTeihoevnetr(aevsarktnesdraondnelppaytrhfsoasrdenseeqd7upairlnlOyE35ii0esAatL1rEiLgblYuatsesdcDuebsecoknegTressftotuhvraetsreceeopinlntiuciavnteeerdse oCaat5nodpuoernelrdyioatrolfsareaefgeecdstut1taohaeastTiiocncacalutlbiyaotnaosroifsdtsueuricisheesdvteshsietshe8lc)ohoolwAseh1L6ietshetou{r(l4uLofirageahstdcoenasutdsuTaBibhgeohrutsrsCadtbuhlactek BSdiruaortvioialtnreedada4oITmoeennene ocotnecennetriatotiyfon3s)sWhEoSveasaccepAtearbalteiosTevvaesiss.otDarpevqouiieresdvteoremasiotntafiond 1o1r8 oftahTmehorebiasluuisbzblaeetrtihooanfl(sLeusfrufvbeiicvltiisnsgy(oltroogsussneiioonfnswieatqnhudiinlitbh1ee5iuosnec,ccounrsdrrsernacatecitcoefrssgvewiabmtlmieietnhaa;slitleaoftsfiseocnto)fs vTVoaictselu"esric,ieyneotxracadidtraebSciholeriadteyd:Cifcdaaiftstcioasllhoiaryeactvaieaoddn.,tiDoeirrsses3lh4vieoadg5ed c4ie8nygheobnuerhsa.v(1iSoTrb)esMdosedrteeel.xtd5eo7tregraanentiievsreesds PItooRnsApte)eru.imteunctce,onnd(uuaRcbTteHirvmiTetrHycLu3t)(y,abCcDho1ecnsp(ooneoSctCkeTart)navesetoredere,lResPftUaoLsrter1du3mseemndetterres:coomribdneesrdtrduPmaEeynLt)1.5Susebaiencrdh feat Chamber that Soained ive animals BTueveicosyatens stady Number 0113 PERRY [Ee El ---- 001615 Pr -- J B BanmReema!iRutofbonheSatoenliotfS y Tteintp eansce e itartrphee ttedbcbyhfsttiandrard fsotaSteismtiicanl Envictosrestdes stay mer 30173 ------ ------- A 001616 B EEEepE---- Ni a* n vin wr 1 EteecAtaIFLbiCevtheierusoptuengrvhceoevsunetsstettlshsuaerrvaetipevpsapetlra.erosecedBcaiutcorelldreoeagdsiicaiaialnTito1thb2ieldaeclalot2ynets4ron2lddqueraAxelppsipostesiynuadrdeieadx.taf1rCg,eoeennrteoerrfsoaplteiecmddtsniopbvlhyeialtityldh,ese BeMeonTtnyy eeerreoesSuiwfneegtctewoeniecghteto.xtioc(xibitlcoyatnttteedsstoddrviyan)smadopfopdre0oc.xy0il0a01stuellgfyaat0te.0rt0he3es5ulegtn/edldoifEnxatphoesdudrteebsotuo,rf | Stila Lethal coacentratios (L650) of 15.6 robte T3he 3s4 u18rd e48ohfoudrupCha5i0d5s ftoor tdhaeshtaeisdts wafLseuxbpsotsaendcetoreTsXul3t8e2d0 ianrea p4r8esbeonutted5Ci5o0 ks San 3830, vith 35% confidence interval of 43 = 56 m/l. EPoargiero1s1ysotfen1s7 Study usher 0171-3 J E B 001617 PR A pi p E> Table 2. Survival dats from toxicity test rer eaber ive exber affected an) re. on he eh ow 200 dr (contro) 1z :3 = 152 13 :5 1i 5: 100 1:3 hl 150 12 3 s ssssa s 5s 3s s s s ss s ss s s sss s ssss3 s s sa3 s ss s aa s 5s3sa s s ss sso00 53 5s s 3 o0 :541 0 o oo oo o 5sooo o o o so ooo30 oo 0 o o ooo o s 5 ooo1 o oo o 20 o oo o 43 s o o ooo:-I so [ o oo o1I= so = Hote: Aaftfteerctegdentdlaephaaigditsavtieorne)Tmschilized (sable to svi vithis 15 seconds EPoavgieco1s2ys01ten1s7 Study Nesber 0171-3 EEE - 3 Tle 3. Netlan effective concentrations (5503) from toxicity test STeroireises 250 confSideerncee nHisits Taacs Whos some - - 8 hoves mn osm raat FIaavetrosyatens study ember 0171-3 oecr emtm DEERE Ba y . mms POiErnCaDc.tthiece1A.9s0s1e.ssm(eD3n1e)tcis3oi0fonC(hFoeifaschta)hl.es.ComcMuislesCo7n.cerOnFiCnDg PtrhiencNiuptlueasl oefceGpotoadncLeaboofraDtaotray OSEEysCsDtt.ess.1o3p84tN.eetdbGouAdipdr2ei0ll2i,n4e,sDa1fp9oh3r4a.iTdesstpi.n,g AocfutCeheTsaimccablisl.izSaetcitoinonTe2s:t BatnfdecRtesproonduBcitoitoinc Sctoempuhmainc,atCi.oEn.. 1983. Computer program for calculation of 150 valves. Personal EPangveiro14syosften17s Study Nesber 501713 | |! | ! BEST COPY AVAILABLE io Table AL. nCeovnsduurcetdividtuyr,ingpf,toxtiecmipteyrattuerset, and dissolved oxyoen concentration concNeonntturaaltion A Coonductivityw(emw boren) segue "ecg FT CE Mh a ofcontrod 31 i1m0e0 n10e na0w 1788 8822 n8e6 5 uam0 1 Dee wbwo Tnas snzz aaee = 310 ame nuee Dwee T1s 8a22 snee 3 namme muem aiwe T7s8 ewzz swee 1Ioammoeo n1e0 muwe T7ss 8822 se 3 uammoe mbewm anwee 77s8 wwzz ewes 21 mmm0o nneo buee 77ss s5z2 esee 3 aa0m uwwe wuew T7ss a8z2 wsse 100 31 moomoe anwoe umwe 778s 8822 swee 5 dmmo Bnme mDem t1es s8z2 aaee ! 150 2Dommee aneo Dmwo 7a8 8833 saes 5 uaem invee bmwo r78s 8833 asse PEaagveiro1s6ysotfen1s7 Study Nesber 0171-3 REE a . mE.Ee we WoTdmr fWFw S E N eo R E wE w E JEST COPYSRVAILABLE i" 2. i. . . } RET