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INDUSTRIAL HYGIENE FOUNDATION OF AMERICA. INC^
4400 Fifth avenue
Pittsburgh. Pa. 15213
July 31,1968 a yu*lif
Dr. Lee S. Grant Medical Director
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PPG Indus tries
1 Gateway Center
Pittsburgh* Pennsylvania
15222
Dear Dr. Grant:
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Following your discussion with Dr. deTrevilie last week. Dr. Gross .was asked for a status report on amosite.
The four- year U. 5. Public Health Service contract only became
effective on July 1, 1968, in support of the IHF Comparative Study of As
bestos Pathogenicity (Phase HI of our original proposal as outlined by
Dr. Gross in the Foundation** Medical Series, Bulletin Ho. 11, "Asbestos
Bioeffects Research for Industry. ") The final report will not become due
until June, 1972, therefore. .
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Because Pitts^o-rg}j_CnlS?had agreed to co-sponsor the Foundation's Fibrous Dust Study in f966-1969J chiefly to learn about amo site's bioeffects. Dr. deTreville had advised Dr.Gxoss s year ago to include amosite in our study as soon as possible and that it would be at IHF expense, if the tJ. S. * Public Health Service funds were not obtained.
2 am happy to advise that 116 rats were dosed with amosite infer*iradically . ?) -a ten months ago. The categories of exposure included amosite subjested'to
hammer milling, solvent extraction, heating (1050* F,) and also treated with aqua regia and chelation (EDTA). While only preliminary results can be re ported now, it does not appear that the various forms of treatment listed above have altered the ability of amosite to produce promptly asbestosis in amiaals which have died or been sacrificed.
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Dr. l~ee B. Grant Page 2 July 31, 1968
The remaining animals will be ''pastured" for the rest of their lives
and bserwd for lung cancer and meaofcheliai tumors. The above studies
so far reveal that amosite behaves like other forms of asbestos' in its ability
to produce fibrosis of the lungs experimentally. Pinal results will become
available in about two years.
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Dr. deTreville promptly relayed the above progress to Mr. Byrl Stout today, who feels that the information provided is adequate and that it will not'be necessary to hold the meeting scheduled for Friday, August 2, 1968.
The signed agreement should now be returned in order that we may send our annual invoice.
In conclusion, let me say that Pittsburgh Coming's continued support to the Foundation's Fibrous Dust studies is greatly appreciated.
Cordially,
HMBjejd cc: Dr. Robert T. P. deTreville
Dt. Paul Gross l/Mr. Byrl Stout
Harry a> Bowman Executive Vice President
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December 21, 1991
Mr, James H. Rion, Jr. Ness, Motley, Loadholt,
Richardson & Poole 151 Meeting Street Suite 600 charleston. South Carolina
29402
**: Xhhavfta County, JaJRjes ....^gfrefftog W
Pittsburgh coming corporation
Dear Jack**?
Ac a rcoult of requests for production end discussion of those rAguftfttft In Court in Verieston, Meet Virginia, Pittsburgh
Corninq Corporation has caused a further review of documents which cane from its files and which counsel for plaintiffs night argue relate to know!adgn on the part of Pittsburgh Corning
CorporaLion of health hazards caused by exposure to asbestos. Ehe search vac done for the entire period of tine in which
Pittsburgh Coming Corporation manufactured Unibestos and was geared to identify documents which may not have been previously
produced to your firm or ifcc affiliated counsel, it is our belief that in the discovery over the years that your firm or its
affiliated counsel have seen virtually every document which came from Pittsburgh Corning Corporation's files and which would fall into the above description- Nonetheless, there are a few documents which have been produced previously but Ihe circumstances as to the jurisdictions of those product!ones arn unclear. Accordingly, In an abundance of caution and completeness, we have enclosed copies of those documents hrnwi t:h.
Dcooabcr SI, 1903 Page TVo
With kindest regards, T an HGGiU/tdt Enclosures
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