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AR226-2772 FOR DU POUT USB ONLY Copies to: Haskell E. I. du ftnt de Neoours and Co., Inc. Laboratory for Toxicology and Industrial Elkton Road, P. 0. Box 50, Newark, Delaware 19711 Medicine HASKELL LABORATORY REPORT NO. 828-81 Material Tested Haskell No. 1) Octanoic add, pentadecafluoro-, 1) 12,037 ammonium salt* 2) 14,249 Other Codes 1) C-8 Study Initiated/Completed 10/28/81 - 11/24/81 * ^Material Submitted by CR&D Department Haskell Laboratory S 6 1000 nig/kg changes the U)xic__e^ects of ammonium perfluorooctanoate in rats. All rats dosed with CheuflBj|Ueither before or after the arairionium perfluorooctanoate had reduced mortalities compared Co the rats dosed with ammonium perfluorooctanoate alone. Procedure: Annnoniun perfluorooctanoate as a suspension in corn oil was administered by intragastric intubation to 4 groups of Crl:CD young adult male rats, 6 per group at a dose level of 500 ing/kg. Three groups of these rats were intubated,either before or after the aminonupi perfluorooctanoate TIie rats were divided into the following groups: Group I: dosed with C-8 only. Group II--nosed with C-8 and immediately followed by a dose of) Group III: dosed wit:h|||------------------2 yhmodurs later closed with C-8. Group IV: dosed with C-8 and 2 hours later dosed with) ^ ^ - Company TSCACBI Does "o',,,,*>." ; ii ".-"rTTiS'giigrsagI' All rats were weighed and observed over a 14-day recovery period and ,then sacrificed. A range-finding study to find the tolerated dose level of <------|--------gwacsonducted prior to the start of the test. The surviving rats were welgned and observed during a 14-day recovery period and then sacrificed.*** Results: Dose (nig/kg) 500 500 500 500 Compound C-8 C-8 C-8 C-8 reatment None ^ Immediate post-dose 2-hour pre-dose 2-hour post-dose Dose 0 mg/kg Mortality 576 1000 ing/kg 0/6 1000 mg/kg 1/6 1000 mg/kg 0/6 CAS Registry No.: ** Composition: *** In a Range FindinR Study, rats dosed from 200-1000 nig/kg, 1 rat per dose level and 6 rats dosed at 1,000 nip/kg, showed no clinical signs of Coxicity. ^y^^-00" - 2 - ^^^^chcm T\Q' ^Ji .""""^"-fHifWffS^ ""' Report by': /^ ^^ H//^^^^JYtjl/^^ Lon Hinckle Technician Reviewed by: J^^/^ L>< 0. Louis Dashlell Study Director Approved by: LH:jrg:WP:3.8 jate Issued: December 31, 1981 Report No. 828-81 CT fIjL^Jt^ -J>- fc^~^JL^ V. Gerald L. Kennedy, pr. Section Supervisor Acute Investigations - - ,,,------'-"-