Document k97xqwbry3RXjaRM9n18a6LaO

^jjaJensJUUt July 1971 rvYLAMlNE PRODUCTION AND PHYSIOLOGICAL MEASUREMENTS IN SUBJECTS INGESTING SODIUM CYCLAMATE. fH** __ i ' i i ------- ................................. . I "`"I'TT"* T 11" 7'VI " i r " 'T "IflWI" and A. A. B. Swan. Tox. Appl. Pharmacol. 15: S3S-S41, March l9Vl ubjects capable of metabolizing cyclamate to cyclohexyl mine Ingested S g. sodium cyclamate -HU0,n for 7orS days. The conversion to cyclohexylamine and consequent absorption was followed by ^'measurement of the amine In consecutive 24-hr urine samples. The maximum dally excretion of ^l^^ylanrine In 5 subjects In a total of 69 volunteers ranged from 0.1 to 0,92 of the dally C lamate Intake. It was concluded that no pharmacologically active concentrations of cyclohexyl amine cV>ei eached In the tissues of these subjects capable of metabolizing cyclamate after dally Ingestion re large amounts of cyclamate for a week or more. -Cond. from Authors' abst. of INDUSTRIAL DUSTS* PENARY COMPLICATIONS OF ASBESTOS EXPOSURE. *31 0. R. Gracey, et al. Cheat 59: 77-81, Jan. 1971 n,*'patient described In this article developed a malignant pleural mesothelioma more than 25 years Rowing brief employment In an asbestos processing plant. The authors discuss the relationship setween asbestos exposure and neoplasm, the Intriguing subject of co-carcinogenesis and the potential hazard to urban dwellers from the Increasing Industrial usage of asbestos. Pleural and oarenchymal fibrosis are common radiologic features of pulmonary asbestosls but are by no means unique to this disorder. Similarly, pulmonary function abnormalities may include the entire gamut of physiologic changes, depending upon the stage of the disease, complications and associated pathologic lesions. Unfortunately, no treatment Is possible for this type of mesothelioma other than temporary Palliation of the pleural effusion. ..Cond. from text '21 MORTALITY IN THE CHRYSOTILE ASBESTOS MINES AND MILLS OF QUEBEC. J. C. McDonald, et al. Arch. Environ. uaith 22: '677-5857June'T971 Of 11,788 persons bom between 1891 and 1920 employed In the Quebec asbestos mining Industry, 88.42 ere traced. Of'these 2,457 (23.6%) had died. Exposure Indexes for each worker were calculated fran job dust levels and duration of employment. The overall mortality was lower than expected for the population of Quebec but In the highest dust category comprising 52 of the cohort, the age- standardized rate was 202 higher than In the other groups. Respiratory, cardiovascular, and malignant diseases In equal proportions accounted for the excess. There were 101 deaths from respiratory wcer Including three from malignant mesothelioma, an estimated excess of about 15 deaths. The difference In rates for respiratory cancer between those maximally and minimally exposed was fivefold and, though perhaps exaggerated, was apparently determined by accumulated dust exposure and duration of employment. --Authors' abst. ziitor'a Soto: In view of questions raised In the past concerning the findings of the study conducted iy IhF in 1957, it Is extremely gratifying to note that the above study, which was more extensive and involved a longer period of observation, effectively confirms the conclusions reached in our study regarding pulmonary malignancy among chrysotlle miners In Quebec. -- D.C.B. PHYSICAL ASPECTS OF THE ENVIRONMENT :: ySE HAZARD METER. J. H. 8otsford. An. Ind. Hyg. Asan. J. 32: 92-95, Feb. 1971 ' "oise hazard meter has been designed to evaluate a noisy environment In terms of the anticipated amoorary threshold shift (TTS). The instrument presents an electrical analog of the Cj component `f the The noise hazard meter was tested with a group of normal Individuals In a noisy "''ironment. Encouraging results are reported and further studies are planned, --Author's abst. 19.