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Study No,
T-7098.2; ST54
al Toxicity Ran;
for Py
mn
Sulfonyl Fluoride (POSF) in Rats
Study Location: 3M Strategic Toxicology Laboratory
Corporate Toxicology 3M Medical Department 3M Center,Building270-SB-314
St. Paul, MN 55144
Study Directo3rM:AMneddriecawlMD.eSpeta.c/aCto,rPpho.rDa.t,eSTr.oxRiecsoelaorgcyh Toxicologist
3M
Center, Building
`Saint Paul, MN
5252104-42E-02
=
Ph.:651-575-3161 FAX:651-733-1773
:
Study Texicologiat: DeannJa. Lucbker, M.S., AdvancedResearch Toxicologist 3M Medical Dept. / Corporate Toxicology
3M Center,Building220-2E-02 Saint Paul, MN 55144
Ph: 651-737-1374 FAX: 651-733-1773
Sponsered by 3M Specialty Materials Markets Group 3MCeater Bldg236 St. Paul, MN 55144
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POSFOral TonT098y2 RaspetSaTdSe4r
StudyOblective
Tohfepreseearrch fobjlectiuveoofthfrilsusotoruiddeyo(wPacOsStEot)pfroaolvliondweipnregealsisimnignulareoylrdaaltfeatxpooocshuanrraeciytnerrialztse.thetoxicity
Method Summary
`(T1)hiassntducdlyawssaisfipeedrasfoar"mCeldaisnstBhSet3uMdSyt"raasteexgpilcaTionxeidcionloTgOyLXabSoOrPat0o9r5y0u,nSdrearteagdiecfiTnoexdipcrooltoogcyal Lab GLPProgram Procedure(2). PpOerSdFowsealsevaedlm)iunsiisntgeraeddotsoamgaelveorlautsmaetodfos$mellevseulsspoefns1i0o0n, k30g0baonddy6w0e0igmhgt/.kgAbuondiyfwoerimght(Ne=1 wssaussyppeenrrsffiiooorrnndwmoeasgdsiwnpeigrt.ehpaArsveetdhriionckl2ees%coofntTthwreeotelinasn8sui0emgiarmlimrneeddceieraiptveeesldtylp2er%bieoTrfwoetroeedtnoh8sei0snaagtm.apReld-eosswueasvpsoednrhsamiwoenn-oouffpsionltihdes lmiivlerkt.iTsshuiessfanoirhmiaslt,ohloowgeicvaelrc,owmapsarhiusmoannienlaynsoatchreirfsitceuddyo.nAdaseycoonnedpgorsto-udposoefiagneo-rmdaetrcthoeodbtaim w`aecnoiingtmhraotllsaannwidamswsaehlrase(ruNesd=eb3de)ftwwoeerrewenetitrgheihasttsgetaduwidinytcaohnmppdroaTpr-yi7ls5eo8nn5ep.u1gr,lpyToc-so7el5as7t.6T.ah1di,osTss-ee7cv57oo4hn.ud1gm,reToo-uf7p5So7m5fU.ck1o,gntTbr-oo7ld57y6.1, seaubnnsddtpioTti-un7tt5i7so7nm.oo1nf.ipHtriosortpeoydrliiencnalehgitlosxysictcouidltyfy.doarAt2lal%oannTitwmhaeelessentw8we0rowevomeuohlindciltneoocrtoesnditfgrnooirlfmisocuarbnbstitldayinetcfyef,semicontrdttihacelaritetesytu,hlaatntsdofthe. bodyweightchanges for two weeks followingdosing,and werethen humanelyeuthanized.
ResanudDilscutssison
A`OpleFrl5i3PodO,+St0Fh.ed1ro8asgtreeadomafsnwioemfiagblhostdsguyarwiveniiwvgeahdtst.coFotrmhpoeamerdnaadbyol2fe-ttpohoteshttewdpoor-sowepetyehlkresontueggulhdtyychpoeelrevineodhdoiacfnltdehgceaoni1tn4re-oddlaaaynnsiatmvuaedlxyea.gs `dTeronasinems.aiTlersnestauwrtevmiiegvnehtdtgltrooostushpweraeessnudlootbsfsaetrrheveestdhiwoonw-tnwhieeenaknTisamtbaulldesydp1.eorsAielolddpw,riaotnphdylg3ea0in0nemgegld/yacknogalvPteOrreSaaFtgeedovnoefdhaSiyc0-l4oenc0eo.pn1eo6r.sotl `sgramhs,ioonrT1aw6bpleenr2c.entoftheiraverageinitalbodyweight. Theresultsofthecontrolgroupsre kTTnhhoeedwhonyspooertlahelevLseiDlssSb0oaofsfbPepOeSnFepwuertrfefocrhtlohsteuhnatiotnooxriridteoyr(rtePoosFucOlcotSmi)nptg,awrfaheoitcnhmhePiresOel2Sas5tFi1evumxegpolo/rsaklugftrioexnocimcaainnltbyeoaerfaatttPtsrO(i3eSb)Fu.ttehdeto thdoesiPnFg.OISenxapporseuvrieoursessutlutdiyngofnrtohmeatbosxoircpktoikoinneatnidcshyodfrPoOlySsFiisnofraPtOs (STF-t70o9P8.F1O),S faotlslwoewrinegdoorsaels adbsoysoPerFdaOlwSgaiasnvptargheeseewlniitvtiehrn.t5Vhmeegrl/yilkveigrt,loeafPnPOdFoSOnFS.wdaOaynsd4faopyuosnotdn-iednoptsoehs,tea-spdeporrsueom,x,isompnapltryeoxlaiybmo1au1tt%e0lo.yf15t%%hoeofdftothsheeewPPaOOsSSEEmed
Paget?
POSEOnlToxiciTt-y7R0a9n8g2e;fSiTndSe4r `dPaoFvsaOeiSlda,oblanentddaotythshaett1looixrviec4riartesysrPpeFescOutlSit,vienltghya.ftAr2so5sm%uPmoOifSntFghteehdxapotososenuilrsyetcaevananiplbeaerbclaeetftnortlioblfuottwehidetndgootassheiemroieflsPaurOlotSriFnaiglsdPoFsOeoSf ePxRpOosSi,rBea,stehdepornedtihcetseedaosrsaumlpLtDiSoOn0so,fthPeO6S0F0wmogu/lkdgbdeoaspeproofxPiOmSatFeulsye2d.i5nttihmiessshtiugdhyewrathsannotthahitgohf erensouulgtihntgoPdFetOeSremxipnoeswuhreet.hIenrotrhdeerttoxoiisnivteysretsiuglattientghifsrhoypmotPhOeSsFise,xpaodsousreeocfaan lbeeaasttt6ri2b8umtegdt/oktghe 'POSFwobue pleodded.
Conclusions
tThhaenroersuelqtusaolfttohi6s0s0tmugd/yikngdbiocadtyetwheaitgthhte(PNO=S1/Fdiossneogtraocuupt)e,luyntdoexritctheocmoanldietraitosnsautosreadlidnotsheissless study.
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Signatures:
Prepared By:
---- T-7098.2; STS4.
a lac gelutl dis r Advanced Research Toxicologist
Study Director
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Study Toxicologist
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`PSaeunlioLrieTdoexri,cPohl.oDg.y Specialist
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References
1) `3OrMaMleTdoixiccailtyDReapnagretfmienndte,rCfoorrpoPerraftleuToorxoioccotalnoegSyuPlrfootnoyc!olFfiouorrSitdued(yPNOoS.F)Ti-n70R9a8t.s2,;JSaTmSa4ry 2001.
2) `3SMtaMnedadridcOaplerDaetpianrgtPmreoncte,dCuorrpeo(rTaOteXSToOxPic)oNloo.gy0S9t5ra0te--gGicLTPoxPircooglroagmyPrLoacbeodruarteo,ry1999.
3) DFelauonr,ocWh.ePm.i,cJaelssSuuprf.aDc.tCan-tT FC-h 95acouteGom .r,aRlop tmoixigcs ,iGty.o (aLnDdSn P0o)wse, tluld,y Di.nr1a9t7s8..ReFlpuoorrtaNdo. 137-083.InternationalResearchandDevelopmentCorporation,Mattawan. MI.
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