Document jyq6Z3JNkYLZRM9ker49y3jjy

DEPARTMENT OF ANIMAL SCIENCE UTAH STATE U N I V E R S I TV L 0 G A N , U T A H 8 4 3 2 1 . COLLEGE OF AGRICULTURE July 3, 1969 Dr. Cummings Paton Organic Division Development Monsanto Chemical Company 800 North Llndberg Boulevard St. Louis, Missouri 63166 Dear Dr. Paton: Through collaboration with Dr. Francis A. Gunther, University of CaliforniaRiverside, I obtained samples of the Arochlor products from your company which have been studied for effectiveness in induction of hepatic microsomal enzymes. The eeitrfe3 abstract which summarizes ~out dork to dace", has been submitted for the program of the Pesticide Division, American Chemical Society for its next annual meeting. Dr. Gunther asked that I keep you informed of our studies, hence this letter. My primary interest in studying substituted biphenyls has been in connec tion with a sizable endeavor to identify significant structure-activity relationships in compounds capable of inducing hepatic microsomal enzymes. We had earlier investigated a considerable series of bridged and unbridged diphenyl compounds involving a variety of substituent groupings. The activities of the Arochlors seem to fit reasonably well with that predicted on the basis of our earlier studies, allowing for the crude composition of the Arochlor products. We are most anxious to obtain pure compounds in the chlorinated biphenyl family and would appreciate any assistance you and your company might be able to provide in obtaining such. In regard to the possible significance of PCB materials in the environment, I am presently fairly openminded. I am impressed with the potency of the higher members of the Arochlor family as enzyme inducers. However, I am by nq-nreans committed to the view that this is -a--awrioas hazard_in itself, t<fTh~e~Kealth of any organism including the wildlife species that have Deen~the subject of ao much recent concern 'because of pesticide residues. The^eTShtlflc""5ussrt5if"Temaihlhg^ih' 'Ehis~af Sa "are extremely complex and much more research information is needed before a clear understanding emerges. Toward that end the continued assistance of your company will be most appreciated and, of course, acknowledged in our presentations and publications. Sincerely yours, 7 JCS: Jw Joseph C. Street ^Professor OSW 018302 STLCOPCB4004846