Document jygx04qDvor5aMbLo3xpR6Ge9

P. C) DuPont Haskell Laboratory for Health and Environmental Sciences Elkton Road, P .O . Box 5 0 ('f 7 Newark, DE 19714-0050 April 2, 2007 Via Federal Expres s 3?~ Document Processing Center (Mail Code 7407M) Room 6428 '` OWA A tt ention : 8(e) Coordinator C S NQ Si Office of Pollution Prevention and Toxics ep U .S . Environmental Protection Agenc y 1201 Constitution Ave ., NW Washington, DC 20460 Dear 8(e) Coordinator : 8EHQ-0381-0394 Perfluorooctanoate (PFOA) Longitudinal Study Supplemen t This letter is submitted as a supplement to our May 15, 2006 submission to the above-identified file . In the May 15, 2006 submission, we reported the results of a longitudinal study of serum total cholesterol related to serum PFOA measurements in a group of employees at the DuPont Washington Works, West Virginia plant that participated at least twice in a voluntary serum sampling program at the plant over the last 25 years . Using a mixed effects statistical model with repeated measures for the 454 employees with at least two measurements of serum PFOA, the essential results showed an increase of total cholesterol with increasing serum PFOA of about I mg/dl cholesterol per 1 ppm PFOA . A poster presentation was enclosed . Additional data analysis of the results of this study has been completed subsequent to the May 15'' submission . From this additional analysis, it was noted that serum PFOA was also negatively associated with total bilirubin (0 .008 mg/dl decline per ppm) and positively associated with serum aspartate aminotransferase (0 .35 units increase per ppm), but not with other liver enzymes . While DuPont does not believe this information is substantial risk information reportable under TSCA 8(e), DuPont is submitting the information to the TSCA 8(e) office in view of the Agency's continued interest in perfluorinated substances . Sincerely . Michae,A l Kaplan, Ph . Director - Regulatory Affairs and Occupational Health AMK/RWR/RCL : clp (302) 366-5260 s C)I~0~~I Ili~I~I~II~I~I~i!Il~I i~l E .I . du Pont de Nemours and Company ,~-~ p. 2 TSCA 8(e) Submission : 8EHQ-0381-0394 Perfluorooctanoate Washington Works Phase III - Longitudinal Study bcc : L .J . Fisher M .L . Rees A .V . Malinowski D . Chas e A .M . Kaplan R .W . Rickard K .K . McCord D .W . Boothe S .E . Sax S .J . DeCarli G .L . Kennedy R .C . Leonard C .J . Sakr Technical File 2