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000402
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fogist 11, 1983
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PERSONAL AND CONFIDENTIAL
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UPDATE ON THE :8 0L00D SPLINE BROGRA
Pader/Dfnispoveerrsailoln ndrsopFiEnD BOlpoeordatoCr8s.TeyTelns dirsopabisnerBvldoodinCT8EFlLeOveWlsFin1se aB stataieesttiocnattllty tssphiaogrnaOitpfoeisrcaatndotyr.asrateIoxnrpseTraeibxlepenecre1d,fenfnotceccdahnaangdbere.onpotTienhdeblftoohouadtr 6r1-e68maouiltenvieonlgfs.22 ete peri here
heneceedd bayIdnrToTopanbliheGrob2,ulpoeoidtofc6a8nOpelberevaetnloostr.esdarTtehhaetvesri1y4gasofunitccaaounfrtag1id5nogwF.nEwParOdpetrraetnodrss eexxppeerrii--
nal 1 iDeata51on6-3inTdhivtihdeuaolsnwdo(Tioofet,TtEhFeLOtWineindIticcaatkeeschatto rtheedubcieolbolgoiocdalC-8
Tevel by 50%) is approximately two years.
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pBiesprerase piToohnteeasante cdesa'cFhoEevFdortOpeTotaarobyarlrtyehao.srdsMcyoabnyltya1sBitlhneo.odGl1Ia5Cnn2fd8oSrpdCmeaac3titifaoidncawteamRreeettfhoroovcidee.rvTieEnrFe)bLdaOtpNsrforgrFuremiacnmot.rhdePeodMFeL1AfrTn/
iTBeEahsavsonvEnposrretMaaddarteasTamErFee.LOmoNcchtuauddeedJ.deessTtnincT7eR3I0SnedonrveeSppre4e5r.aotforOtshnweitdf)a1treaSxtpoenorfiOetpnhecerea.ttronor=s
Creseing Host C8 evel ant an eqSuoriium eve 15 resched
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000403
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AUST 12, 1983
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J$43 &arvoepraTgne b1i.o2okpmC-8(s1eeeveTlasbleove2)r..theThepassetOpteorayteoarrss.experienced an overall
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SFCeatuYvseteirSosinosBnoisafirienesnso tdeoaumbst dtoueretdouecfefCor-t8simnadaeirblyevTeElFsL.OW Copolymers and
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{+ Hon 'be considered as a replacement for the C-8 paler
~~ . ) dReroeeaidctaotEetBalroatonhldasetfvCeee-rln8sotdrbhayetraeSatOwvFie.errreeamTgehenobittsIat(isinteseaedkceaToslanlbeladepfpitrv3hoe).xeiinnbDaidtoiaelvoligydiuocnaTalwltsohwyehehsaaoelrflsi-en1ftdftiofveTi.rdEeuFdaLilcOseW,
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000404
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Troe FE poy 1spERsIN PERATIRS
B-R8 En} BLOOD SAMPLE RESULTS
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DFAITRESTOF CB8LOIN DJAOYBSATIN DSAETECOOF BcL-8OODIN DJOABYSATIN
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SWPLE' (PH SAPLE DATE SAMPLE (PH) SAMPLEDATE
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Cwm 0
2mm2- 20.0
9,38
232
vies
gums
220..00
82.,7629
wes 10 S20 yer 8.2 9,651
sm sa 23 gem 7: 2,743
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wys 82 S813 ym 6s 6.176
ynsz 70
Les zim 77
2,353
zm 6s Ls mse 2,080
yam ss san yum a2 8,645
C ~p )
ywiessz 44.34 ym 39 ws 3.6 som as yamz 2.9 wy 28
5,s76s5 sisesz 46.9 sym 36 sz wm 27 mo emma sa yw 28 2.25% ays 28
. 61,,12380 1,168 1,32 Law 8,59 2,621
3/1/82 2.6
1,621
4/6/83
2.4
2,012
*
7/16/81
2.5
5,652
6/17/82
18
5,988
7/16/81
2.5
1,708
6/30/82
2.5
2,054
4/6/81
2.1
918
M1s/82
1.6
1,206
3/o3o/s8z2 11.s6
5,8m8o0 3/a22/s83
11.25
61,,21634
weer 13
1803 oes 1a
2,165
T=6.3 ppm
X=5.5 ppm
1264
oGouuuttt
ooofff
222222
eeemnmpppllloooyyyeeeeeesss
eeexxxpppeeerrriiieeannnccceeeddd
dneocrCehaasnegde increased
BIlnoboldooCd-8CT-a8veJlesv.als. blood C-8 levels.
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Bacresse in 0-8 in blood levels is statistically significant at p = 0.05
838-26048-3
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000405
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THLE 2
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IEfFElP QoPERlATOeRS Co BLOW SOLE RESTS
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HMDAETRESTOF BGCE8ASAIN- MDMAeeYSlrIlNow SSDATwmEeoOF Cs(a8o)mIN uSDAesYcSaorIH
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4) Vise os sem yum oe sm 4/7/81
4.5
yuseee 321a soesmu yqzmss 2L8s 90.0.2 i aise 1.8
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12/16/81 Le
LC ygmamm wLas wwrm ownsmez 1L4a 13o8n |
C.
3/3y82
0/28/81
10/15/81
0.95
0.86
0.75
1,284
4/22/82
3.7
9,249
1/26/83
11
1,977
112/83
1.6
5,813
899
1,807
4/26/83
5/16/83
0.79
0.75
10/14/82
0.72
1,664
9,613 2,369
6,204
1,464
2,1m
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e89w1
mm om wn
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10/28/81 0.38
1,927
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X= 14m
s7/e29s/8s2 0 0.48 sae ods
10/26/82 0.36
T= 120m
21,822%8 Le
2,290
14/15 eaplayees experienced dacraased blood C3 levels.
era in C-8 1n blood t levels is statistically significant at p = 0.05 :
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000406
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EPLOYEESWoLEFTTERLO 0085
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C-8 IN BLOOD WHEN C-3 IN BLOOD AT DAYS ELAPSED- REASON FOR LEAVING
LEFT TEFLON (PP) A LATER DATE (PPM) BETNEEN SAMPLES
TEFLON
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ss 19.0
22 16.0
128
Retired from Company
Bo Retired from Coupany
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2.1 0.57
22+
333
Retired from Company -
0.14
730
Transferrendietto ston
0.14
0.08
759 : eTrtanrsfeerredottoviston
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+sTshp increeaserin Ca8 blohoad rTeevsesaiswkhoemlEe de to amalytical error Biological half-1ife of C- fn Blood based an these data pofats is
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000407