Document jyJO3zNKNoQBz6LeEBgXpwBQQ

ELEMENTS OF INDUSTRIAL TOXICOLOGY the red corpuscles It is believed to be ically keep themselves dry without loss of more toxic than either but is not so often solvent encountered in industry. Its most important toxic effect is depres In an investigation of workmen in a sion of the central nervous system In ex foundry who had been exposed to 0 1 to 10 perimental exposures of human subiects, mg of tellunurn per 10 cu m of air, a large those exposed to concentrations greater percentage of the men showed die garlic than 200 ppm promptly suffered central ner odor of the breath and sweat and also com vous system symptoms, while those exposed plained of dryness of the mouth and a to about 100 ppm did not metallic taste Men with the highest expo sures, who also had the highest rate of tel lurium excretion, showed drowsiness start See Hygienic Ginde Tetraethyl lead--see Lead ing in the early afternoon and later becoming more severe Complaints of loss of appetite and nausea at these relatively low exposures were less common Tetrahydrofuran (tetramethylene oxide) is used in chemical reactions and as a sol vent for resins and plastics Both acute and chrome exposures constitute a moderate 1'EPP (tetraethyl pyrophosphate) is the health hazard Symptoms of overexposure active ingredient in an insecticide mixture that goes by the same name Since the esti mated fatal dose for a human being is ap proximately 600 mg taken orally, it ls in the class of highly toxic materials --nausea, dizziness, and headache--soon dis appear when fresh air is inhaled Kidney effects reported in early studies were prob ably due in part to impurities m the com pounds tested In Us use, toxic dust respirators or sup See Hygtemc Guide plied air respirators and protective clothing which will completely prevent skin contact should be worn Anyone with a severe headache or a feeling of tightness or con striction in the chest should be removed immediately from the exposure Tetryl (2,4,6-tnnitrophenyl-methylrutramine) is a high explosive notable for its ability to produce a severe dermatitis by di rect contact and a high grade of sensitiza tion in some persons There is some evi dence of a slight systemic toxicity, not as 1,1^2-Tetrabromoethane (acetylene tet- important in practice as the dermatitis rabronude) is a high-baling, heavy, yellow The systemic toxicity seems to consist of ish liquid used as an indicator liquid m general central nervous system symptoms gauges and for separating minerals by densi and anemia, although there is some evidence ty. Its k>w vapor pressure at room temper ature makes it safer to handle than might be expected. The LD for rabbits and gumea pigs is about 0 4 g per kg of body weight Exposure to the vapor causes respiratory irritation and damage to the hver appealing a few days after a single acute exposure. of hver damage and lung involvement from heavy chrome exposures The dermatitis usually develops in the second or thud week of contact with tetryl. It is commonly accompanied by imtabon of die mucous membranes of the nose, nose bleed, and yellow staining of the skm of the hands, face, and scalp Loss of appetite, 1,1,2^-Tctiachloroethane (acetylene tet rachloride) is an excellent solvent for a number of paints and lacquers It is also a very dangerous compound since inhalation of it at a concentration that is barely per ceptible by odor can lead to extensive hver damage Tetrachloroethylene (perchloroethylene) >s a chlorinated solvent used primarily for degreasing It is similar in its properties to trichloroethylene except that its boihng point is slightly above that of water so that boilmg degreasers containing it automat abdominal cramps, and anemia are often seen in tetryl workers Reduction of contact with the material by dust control measures accompanied by zinc oxide protective cream and work uniforms, including caps, will greatly reduce the haz ard Most people who develop the derma. btas m a mild form will respond to treat ment and acquire a certain tolerance so that they can continue working There is, how ever, am true immunity to tetryl People who have worked with the material for years develop dermatitis if the exposure is increased There are also some cases of 40-55