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MINUTES ARDCLOR - WILDLIFE; REVIEW OF BIO-TEST . STUDIES MONSANTO GENERAL OFFICES MEDICAL DEPARTMENT ST. LOUIS, MISSOURI September IS, 1969 TO l Those Present M. W. 'Farrar W. H. Hunt R. E. Keller R. E. Kelly E. S. Tucker E. P. Wheeler . Not Present W. R Richard The above attendees reviewed with 0. E. Fancher, Director, Industrial Bio-Test Laboratories, the biological results to date of their feeding studies and the consolidation of tissue samples for residue analysis by the Analytical Group of the Applied Sciences Section. PUR. 022556 SCM 038*98 EXHIBIT NO.--li- HARTOLDMONOO11689 2- A detailed analysts of the currently planned analytical support work for the Aroclor - Wildlife project was prepared for this meeting. Table I. The analysis includes a listing of studies, manpower requirements and a dollar cost for the analytical support of each study. In brief, it was ascertained that there were at least five separate Bio-Test feeding studies in progress or planned which would require 105 man weeks to analyze the estimated 1340 samples being generated, At a cost of $63,000. An additional $18,000 of work not involving Bio-Test is also outlined in the Table. ' Meeting Objectives * I. Review Bio-Test feeding studies with special regard to the scheduling and reduction of the number of samples to be analyzed. II. Status review of the biological results, to date, of Aroclor - Wildlife Bio-Test feeding studies. With these facts in mind, each Bio-Test study listed in Table I was critically reviewed to determine if the number of samples requiring residue analysis could be decreased without appreciably effecting the results ^ .. . 1. Rat Tissue Study ' Actionss - Delete residue analysis of rats fed chlorinated naphthalenes and pesticides. * Pool male and female animals. 2. Chicken Toxicity, Reproduction, and Meat and Egg Residue Study ' Actionst - Pool larger numbers of eggs. . - Analyze only fat, muscle, and liver tissues. - Restrict analysis to one, no effect " level for each Aroclor. . 3. Mallard Duck Study Action: - Equivalent to Study No. 2. 4. Two Year Chronic Toxicity in Rats Actions: - Delete 9 month sacrifice. PRR 022557 il*9 SC* PS-*--* ST** HARTOLDMONOO11690 -3- Actionst (Cont'd) - Pool all male and female animals. - Restrict analysis to one, no effect level for each Aroclor. 5. Pish Toxicity Study . Actions; - None; study design requires this number of samples. 6. Rat Reproduction Study '. Actionsj - Addition of 2nd litter, 1st generation, rat pups to be analyzed. 7. Two Year Chronic Toxicity Study in Dogs ' Actionst - Addition of selected tissues for residue analysis. TABLE II AROCLOR - WILDLIFE ANALYTICAL SPPPORT REVISED (Bio-Test Section Only) No. Samples Man Weeks $ Cost I. Residue Determinations . A. Biological Residues (Bio-Test) Rat Tissue Study 40 3 1,800 && 2. Chicken Toxicity, X xT *.-.4,800 * * yvc T Reproduction, and Meat and Egg Residua. /A *- 1 < OCX Study 4. -Mallard Quote-Study* I" 4. Two Year Chronic Toxicity in Rats I UK . 160 CP 12 7,200 -4.'*-* 5. Fish Toxicity Study 6. Rat Reproduction Study 60 10 -f (5- 9 `1 5,400 iVc* . 600 3#i' -CC 7. Two Year Chronic . Toxicity Study in Dogs 40 r?) 3 502 44 1,800 >''00 26,400 PRR 022558 SCM 038300 HARTOLDMONOO11691 -4 It is important to note that neither Table I nor the revision take into account work done by the Spectroscopy Group (GC/Mass), duplicate analysis of samples, nor any additional method development required. The results, to date, of the biological studies were issued in progress reports distributed by Or. Fancher. Additionally, arrangements were made to have Bio-Test store tissue samples in Chicago until they can be analyzed. db Attachment E. S. Tucker PRR 02*559 sew o*8301 HARTOLDMONOO11692 . *w I* Residue Determinations . Charges A. Biolocical Residues (Bio-Test) 1. Rat Tissue Study 2. Chicken Toxicity, Reproduction and Meat and Egg Residue Study 3. Mallard Duck Study 4. Two Tear Chronic Toxicity In Rats 5. Fish Toxicity Study Reg. Reg. Reg. Reg. Reg. 1. Environmental Residues 1. Outside a. Lake Michigan WART Study b. Detergents & Components Reg. Inorg. JSancles 160 360 360 400 60+ TTXfT * * 12+MD 20+MD Man Anal. Weeks Cost {$) 12 7,200 27 16,200' 27 16,200 30 . 18,000 f 5,400 1ST . 61,00 0 2 1,200 3 1,800 2. Monsanto .. a. Anniston - Water/ ' Sediment/Fish . b. WCX - Water/Sediment # c. Pensacola - Water/ Sediment/Fish d. Ruabon - Sediment e. Florida - Soil Poison Test Samples (Soil) Mfg. Mfg. Reg. Reg. Reg. Special Studies A. Ultraviolet Degradation of PCBs, et al ' Reg. B. Water Extractability of PCBs from Painted Surface Reg. C. Characterization of Competitive Reg. PCB Products D. Analysis of. Auto Exhausts for PCBs Beg. E. Analysis of Pesticides for PCBs Reg. F. Determination of the Quarter Reg. Phenyl Content of Aroclor 5460 14 in hand 13 in. hand 12 in hand 4 in hand 45 X 2 165 1 1 1 1 5 14 600 600 600 600 3,000 8,400 MD ' MD MD MD MD MD -------- 4 2,400 3 1,800 1 600 L 600 y 4 1,800 2,400 17600 TOTALS* Assumption - 3 hr./sample $15/hr. - $600/wk. MS - Method Development 1505 135 81,000 PRR 022560 SCM 0383Q2 HARTOLDMONOO11693 ORIGINAL IN THE COURT OF COMMON PLEAS PHILADELPHIA COUNTY IN RE: PAOLI RAILROAD YARD ) PCB LITIGATION, ) ) ) ) MASTER FILE ) NO . 90-0609-C-6 EXHIBITS TO THE DEPOSITION OF R. EMMET KELLY, DECEMBER 11-12, 1990 M.D. GORE REPORTING COMPANY 408 OLIVE STREET ST. LOUIS, MISSOURI 241-6750 HARTOLDMONOO11694