Document jrmX3NRwdDx1Rxa3MD335qap

December 5, 1962 TOXICITY AND SAFE HANDLING OF PYDRAUL A-200 Animal toxicity studies with this product have indicated that the oral lethal dose (LDk0) rate is 10,500 milligrams per kilogram. The lethal dose when the material was applied un diluted to the unbroken skin of rabbits is approximately 1250 milligrams per kilogram. We conolude from the above that accidental ingestion on the part of humans is not a particular hazard in view of the high oral lethal dose in rats. Similarly, single massive skin exposures should not be Immediately hazardous. The lethal dose obtained In skin penetration studies is such, however, that prolonged and repeated skin oontaot should be avoided because of possible systemic effects. In addition, prolonged and repeated skin contact may lead to skin irritation. We also feel that vapor inhalation should be avoided when the fluid is heated to elevated temperatures. Such exposure again relates to prolonged or repeated exposures rather than short term massive or aoute exposures, in the oase of the latter, workmen would not voluntarily expose themselves to concentra tions that are hazardous because of irritation of the respira tory tract. The use of Pydraul A-200 in industrial hydraulic fluid appli cations should not present toxicity hazards during the transfer of the fluid from original containers to the hydraulic system. Obviously, when the fluid is within the hydraulic system, there should be no exposure and consequently, no hazard, in the event of rupture of hydraulic lines and subsequent splashing or spraying of the fluid on the heated surfaces, vapors of the fluid and possible decomposition products (depending on the temperature of the heated surfacejmay be Irritating if inhaled to the degree that workmen will not voluntarily expose them selves to toxic concentrations. No hazardous exposure should result during the interval required to shut down the system and obtain suitable respiratory protective devloes during repairs to the system. DSW 009491 STLCOPCB4001214