Document jnxwj8p6kroKNkNZXq40489N

FILE NAME: Kent (KNT) DATE: 1953 DOC#: KNT131 DOCUMENT DESCRIPTION: Book Excerpt - Recent Advances in Pathology Asbestos, Talc and Other Silicates REICNEPNATTAHDOVLAONGCYES SIXTH EDITION By Various Authors Edited by GEOFFREY ^ADFIELD M.D., F.R.C.P. S irRWoyiallliaCmollCeoglelionfsSPurrogfeeosnsosrooffEPnagtlhaonldogy, With 86 Illustrations THE BLAKISTON COMPANY New York 1953 Ludford, MacCallu R. m, WJ.,. aGn. d B19a0r3l. o wB, uIlIl.. Jo1h9n4s5.HoCpakn. cHerosRpe.s,e1a4rc,h1,055,. 257. P ars4o4n1s., R. J., and K id d , J. G. 1936. Proc. Soc. Exp. Biol, and Med., 35, P arsons, R. J., P assey, R . D., aDnmdoKchidodw,sJk.i,GL. ., 1R94e3e.d ,JR. E., xapn. dMAeds.t, b7u7r, y2,33W. . T. 1950. P ortBeiroc, hKim. Ric.a, aenl dBTiohpohmyspiscoanA, cHta.,P4., 31991.48. J. Exp. Med., 88, 15. P P dll ull in in o g er, er, BB.. ID).. 11994592.. LBarnitc.eJt,. iCi,an8c2e3r., 6, 69. ReseaWrcahshCinogntfoenre,nDce.Co.n Cancer. A.A.A.S. for Advancement of Science, 1945. RRoouuss,, PP.., a1n9d11K. J. idd, EJ.xpG..M1ed9.3,81. 3,J3.9E7.xp. Med., 67, 399. Rous, R usse P., ll, BM.uGr .p hRy. , J1.9B10.,. anJd. TPyatthl.e Br ,aWd .,. H14., 34149.12. J.A.M.A., 58, 1840. S S e h lb op ie e, , RF. . ER. . 11993456. . PBrroict.. JSo. cE. xEpx.pP. aBthio.,l,2a7n, d14M3.ed., 32, 830. S"mAitShy,mWp.osEiu.,manodnRMoaums,mPa.ry 1T9u4m5.orsJ.inEMxpi.ceM."ed.1, 98415,. 62W1.ashington, D.C. "WLoegsloUmlt,raWvi.ruHs. de1s9M13a.lad"ieTshAenSimtuadlyeso."f E1x9p4e3r.imePnatrails.Cancer," New York. CHAPTER VII THE CAUSATION OF CANCER : FURTHER CONSIDERATIONS SOCIAL AND RACIAL FACTORS IN CANCER staTtuhse oinnfltuheenciencoifdehnycgeieonfe,caonccceurpahtaiosnbaeleennvthireonsmubejnetctanodf asofcaiasl c1i9n4a8t,in1g94s9e)r.ies of papers by Kennaway and his co-workers (1947, froCman1c9e2r1 otfo th19e45L uinngm. alTeshis(indisEenasgelahnads ainncdreWasaeldess)i,xwtehenerfeoalds cancer of the larynx showed little change. KeInnnaawttaeym cpatimneg ttoo theexpcloanincluthsiiosngtrheaatt "inaclrtehaosueghofthleunignccidaenncceer roofaldundgusctan(cbeeraroinngthinosme ioncdcutpararteiodnsrowadhse)re. t.lnS."reisisraetxhpeor,suarbeovtoe tinhceregaesneerianl ltehviesl,diitse.saeseemsamvoenryg qtuheestgioennaebralel wpohpeuthlaetriotnhecraencebnet athttirsibinucteredasteo btehgeantacrorianl-gtaor fwraosadbse.ingFdoirscshcaorrgeesdoifntyoeathrse baetmfoore sphere in the form of soot by the domestic fire in quantities Tvaasrtrliynggroefarteoradths ahnasanuynd"otuhbattedcloyulidncnroewasebde tdheerivaemdofurnotmofrodaudss.t derived from tar in the air, but this increase appears negligible imnucloe-msppianrniseorns wshiothwthaen aemspoeucniatlolyf ssomoat lallrleiaabdiylitpyretsoencta.n"ce"r Coof ttthone lcuanngc,ear lothfothheghskthine.y" inhale air sprayed with an oil which produces the" Tlohwe hmigohrtamliotyrtailnityagfrroicmultcuarnaclerococfutphaetilounnsg, ianntdowthnes (aSbtsoecnkc)e, ofafcstoocriainl gthraedaiiernstu(cShteavsencosoanl )smaroekec.o"mpatible with an etiological Kennaway (1947a) is led to conclude that " coal smoke tdhoeeslunnogt." ac"coOunnet mweulslt flooroka, ntyherreefcoernet, fionrcrseoamsee ionthecranfcaecrtorosf ttoheelxupnlgaiinn trheceenintcyreeaasres., ifMtahneyresuicshafarcetaolrsinhcarveeasbee, einn scuagngceesrtedo,f ge.ags.esinafnludenoztha,er teombaacncaot,ionpso,piunlcalruddinruggsle,adtaerrtheydl,, rmoaodtso,r vexehhiaculesst 143 222 VOSEASEIS OF THE LUNG Pneumoconiosis due to Silicates 1 whFeitbhreor ussilicSaitleicsaateres :toxAicsbwehsteons,inThaallecd. hTashebeqeunesvtieorny amsuctoh pdoebtaastseidumsinacleumJoinneiusm(19s3il3ic)apteu,t ifsortwheardcatuhsee voiefwmtuhcaht sinerdiucistter,iaal sliitlitcleosissu. ppOofrt.recCenetrtyaienarss,ilihcoawteesvearr,e hnisoxviioeuws, haansdretcheeivecdhievferoyf Tthheesree isartehe twgroouvpieowfsfibrreoguasrdminignerthale simlicoadtees okfnodwevnelaospamsbenesttoosf. asbestosis. According to the one, the action of the dust is mcheecmhiacnailca;llyth. e Eotxhpeerrivmieewntssucpaproriseeds tohuatt atthethaesbSeasrtaonsafciblraebs oarcat tthoerioersy(,TsriundceeaualAumnninuiaulmRehpyodrrt,ox1i9d4e8)wdohicnhotnseuuptpraolritzeths ethcheemtoixciacl aficbtrieosn sohfoqrtuearrttzhadnoes20npo, twperreevefonut nadsbetostobseis.relMatoivreeolyveirn, naoscbueostuoss, whereas if the action were chemical an increase in potency would hinavtheebceaesne eoxf pseilcictead. wAitchomrepdaurcistioonn oifnthpearetifcfelect soizfeasbbeelostwos5fpi,b, raess 15fj, long with those 2-5/x long (King et al., 1946) showed th at rfaobrmbiatstiornececivoimngparthabelelonwg itfhibreesxpdeervimeloenpetadl asinliocdoutilcar nroedtiucluelsin; arentiimcuallisn refcoerimviantgionth.e sThhoert lfoibcraelsizadteivoenlopoef dthaediaffsubseestionsterlesstiitoinasl atopopebairgedfotro redmepoevnadl boyh tphheagsoizceytoefs,ththeefirberaecsti;onwriethsullotendg ifnibrtehse, formation of connective tissue within the alveoli ; with shorter fdiibffruessecainptaebrlsetitoifalbefiibnrgostiask. enThinetsoe twheorkaelvrseoslaurggwesatllsthtahtereif wthaes fibres were shorter than 2-5^ they would be completely removed f(r1o9m48)thceonacllvuedoeldarfrwoamllsclainnidcaflaiinl vteostpigroatdiuocnethfiabtrowsiosr.kerJsohenxsptoosneed tsouffheirghfrocomnceansbtreasttioosniss. ofTehxetreSmaerlaynafcinewaosrbkeesrstoscodnucsltuddeid thnaott afisbbreesstosdiusriinsgcatuhseed mboyvemmeecnhtasnicoafl irrersiptairtaiotinonf,romandthethaastbesthtoiss bpyecoutlhiaerrityforiseigrenlabteoddietos. th-Tehfelevxiiebwilittyh aotf mthoevfeimbreens tnooft tphoessleusnsgeds iosrgaanfascotothr eirs tshuapnpothrteedlubnyg (tGhearadbnseern, c1e93o8f)r.eaWctiyoenrsto(19a4sb9)esptoosinitns out that if the fibrous character is absent, as in the case ASBESTOS, TALC AND OTHER SILICATES 223 of serpentine, the chemical equivalent of asbestos, the dust is ineTrth.e association of carcinoma w ith asbestosis has been mentioned above, but more details may be given here. An analysis of 235 cInassepsecotfoarsobfesFtoascitsoriisesg.iveCnainncethr eof1t9h4e7 lruenpgorotropf ltehueraBorictcisuhrreCdhiienf 31 (13-2 per cent., average age 52-1 years). These figures were contrasted with the much lower incidence of cancer of the lung i(nav6e,r8a8g4e caagsees5o9-f4siyliecaorssi)s., oAf whhiogmh i1n-c3i2depnecre coefntt,uhbeardcuclaorsciisnowmaas also associated with asbestosis, and the Inspector of Factories found 72 Talc. iNnsutmanecreosusinca1s3e0s coafspenseoufmaoscboenstioossiiss. due to talc (hydrated wmoarglnde, saiunmd tshileicafitres)t hoafvtehibseetynpdeesincriBberidtaiinn,dipfrfoevreendt bpyartasutoofptshye, was reported in 1949 (McLaughlin et al.). Throughout the lungs ethsepreeciawlleyrein gtrheeylonwoedrulleosbesw. hiMchichroasdcopcoicaalellsycetdheinnodsoumlees sphloawceesd, wWhiothrliinngt,hebunot dtuhliess hwaedre nfoibtret-hlieketysptriuccatluarepspeuapratnoce40oj.finsilliecnogsitsh. arranged singly and in clumps. Some were very similar to asbestos abnoddieass,baesntdostihs earaeppseimarialanrcedsisseuagsegsesatendd tthhaatt ttahlce pfonremumerocmoanyiosbies caacutisveedlyofnilbyrobgyenitchethfainbrtoaulsc, vaanrdiettiheiss omfigtahltcb. e Adusebetsototsheishimghoerer ppnroepuomroticoonnioofsisfiborcecsurirnedasibnes1t4o-s5. peInr cNenewt, oYfotrhke Swtoartekedrsisianbltihneg talc mining and milling industry (Siegal et al., 1943). The dust caossnotcaiianteedd fwiniet,h satnraiignhcrte, anseeeddsleu-slcikeeptfiibbirleitsy. toThtuebtearlcculfoisbirso.sis was incGrelaashisngWquooanl.titiGeslafsosr ihneatht einfsourlmatioonf ,fiannedfdiburreisngisitbsepinregpuasraedtioinn aNnod huasremthaepaptemarossptoherreesumlat,yhsohwimevmeer,r farsoma reesxuplotsoufreflotoatitnhgisfidburesst,. strinactieonthoewfiinbgrestodtohenohtigrhemelaeicntrsousstapteincdcehdarigneaopnprtehceimab.le Gcoarndcneenr (1942) considers that the material has not the properties required to produce fibrosis. Non-fibrous Silicates : F u lle r 's Earth ; Mica. F u l le r 's eSaurrtrhe,y,cowmheproeseifdismqauianrlryieodf, dariseidlicaanted corfusahluemd.iniMumid,dliestofnou(n1d94i0nj has given an account of the radiological and pathological changes