Document jmvxBKjN8YdvO6RvepQBD9KxO

` GENERAL INSTRUCTIONS FOR SUBJECTS OF LEAD INHALATION STUDY '' " (i960)" TM: ; - '. \ i ' : V. .. The reason for this study is to obtain information on the metabolism of lead which is vital to a clearer understanding and better control of industrial and public exposure to this'metal. The part you play in the study is of the utmost importance. The ultimate value of the work, time, and money spent by other members of the laboratory staff is directly dependent on how honestly and carefully you do your part. . In accepting this job you accept the responsibility of being a reliable subject. ., ;; Schedule . . . . . .. Schedule will be given separately. Necessary supplies and equipment for carrying out the day's . work should.be kept on hand by the-subject and, in so far/as possible, -' the work schedule for the day should be anticipated in order that conferences with others outside of the chamber will be kept at a minimum., When it Is necessary to communicate with persons outside of the chamber the telephone should be used. Materials, papers, etc. which cannot be obtained before entering the; chamber, or which are needed before the end of the working day, should be delivered and called for by messenger or other personnel. The subject can make arrangements/ CO by telephone for such delivery to an from the chamber. ' ****' CD <o The Laboratory will pay for clothing worn in the chamber. Uj This clothing should be washable as it must be laundered by the subject. The following is a recommended list of clothing for each subject. These should allow the subject to stay clean and have plenty of time to get 4 pair pants k shirts 10 handerchiefs 1 pair shower slippers 1 pair regular slippers 6 bath towels 10 pair shorts 2 wash cloths 10 pair socks 2 laundry bags 1 bath robe 4 lab coats (furnished by the lab) Lockers are in the large room containing the chamber. Use one locker for clothing being used in the chamber. Use another for your street clothing, and use another to store clean chamber clothes. Street clothes and lab coats worn outside the chamber may be laundered or cleaned as the subject desires, but clothing worn in the chamber must be kept separate and washed separately from all other clothes. . ' The clothing worn within the chamber is not to be worn outside the Laboratory building, and the subject's street clothing is not to be worn inside the chamber at any time. Mis ce,11ane ous '. , Approximately once a week tests will be made to determine the subject's ''lead retention." This involves breathing into special- apparatus for a specified time. Other tests of similar nature may be made from time to time. It Is expected that the subject will become thoroughly : familiar with the apparatus necessary to determine the lead content of air and that occasionally he will be provided with such equipment with which he will obtain samples of the air of his home for lead determina tion. ' . Hygienic instructions . These instructions are intended to simulate those which -' . . : '. - 3- exposure to lead dust or fume is done. They are designed not primarily for the safety of the subject, but for the avoidance of minor but theoretically important types of exposure to lead other than those actually intended experimentally. The subject should bathe and wash hair at the end of each day spent in the chamber. This is necessary so that no measurable amount of lead deposited on the skin of the body or in the hair shall remain there to be carried about, distributed into the air and breathed by the subject or by others. The amount available for this purpose 30 uld.be so small as to be negligible, in all likelihood, but good, experimental technique calls for the avoidance of even this minute source of exposure. : It is apparent also that care should be exercised in seeing that the clothing worn in the chamber is not brought into contact with- the clean clothing or with the skin of the body after bathing, The technique of handling the clean and unclean clothing and keeping these entirely separate from each other should be carried'out faultlessly at all times, as a good experimental program. n :When the subject leaves the chamber for lunch .within the Laboratory or for any other purpose (within the Laboratory) during the course of the day's stay within the experimental room, he need not bathe and change all clothing, but should wasijhis hands carefully so as not to contaminate his food or any other subject. This should be done after the removal of the Laboratory coat which is to be worn CD O at all times within the chamber. This coat is to be put in its proper <> place when the subject leaves the chamber. Another laboratory coat, kept outside the chamber, should be put on over the other clothing worn within the chamber, so that the hands will be protected against contact with clothing worn inside the chamber. This coat must be laundered . 4- - Arrangements will be made for a place to eat lunch Note the place agreed upon in your record book. If there are exceptions later these must also be noted. Never eat or drink- anything inside the chamb Lunch should be taken, usually, within the Kettering Laboratory buildin so as to make it possible for the subject to avoid bathing and changing clothes completely at noon, for these precautions must be taken if he goes outside the Laboratory. With the provision for washing the hands and changing the laboratory coat he can take lunch in some designated part of the Laboratory building. , . ' . .. The cleanliness of all lockers shall be maintained at an . excellent level.by the frequent use, (at least twice per week) of a vacuum, sweeper or by wiping out with damp cloth. -, The floor, desk, chair, and all, other objects within the chamber are to be cleaned daily by the subject in accordance with the instructions given-under Housekeeping. .. . Collecting samples ;. v, So far as possilbe routine samples (food, feces, urine) shall be collected during the hours spent outside the chamber by the, subject. The lunch, if brought from home, should be put up into two identical packages, one of which is to be eaten, the other- to be introduced into:a separate jar which is properly labeld for identi.fi- cation. This is, to be done within the room in which the lunch is take (open both packages, eat one lunch, then put other one into jar) so that by handling the two duplicate lunches in as nearly identical a manner as possible any possible contamination of one (with hands or otherwise) will involve the other correspondingly. " When urine is to be voided into the container during the daytime (spent within the chamber) the subject should remove the inslld  - 5- . laboratory coat, go outside chamber, wash his hands carefully, and ' void directly into the container, taking meticulous precautions against any unnecessary movements of body or clothing that might distribute dust from the clothing into the air or into the container. These same precautions should be taken in collecting a sample of feces during the daytime. All such samples shall be labeled carefull with the time of day at which they were collected. Operation of the Room, Air Sampling, etc. In general the chamber will be operated by a technician other than the subject himself. However, it is expected that the subject ;will become acquainted with the mechanics of operating the room and that he shall (after instruction) check periodically certain of the Instruments and make minor adjustments. Also he will be instructed and requested to help in taking certain air samples within the room from time to time. Housekeeping . , . ; ,' . V . In addition to the normal, cleaning and dusting;It will' be ; necessary to mop the floor of the chamber each day before closing down. This Is an integral part of the experiment to prevent accumulated dust from changing the established concentration. It cannot be done by janitors, and it is expected, therefore, that the occupant will do this work. Set trash outside chamber each night for collection by janitors. :: . ' ' ' . . . '. . . Dcors The doors of the chamber should be kept closed when they are not actually in use. The vestibule doors shall be closed immediately on entering, and not more than one vestibule door shall be opened at the same time. The emergency door should not be used other than in an emergency. ' * ` 000441? ' - . ' .. 6- - Los Book A log book shall be kept and entries made each day the room is occupied. Time out of the chamber exceeding 5 minutes shall be duly noted in the log book. Time of entrance and time of exit shall be entered. ' . In a record book kept in the custody of the subject, other information should be listed daily, as follows: a. ; Pood and beverages taken at each meal, itemized; ; b. Any unusual circumstances occurring in the course of the day, the effect of which might influence '-the-,experimental . results; . c. Any event or incident which actually did influence the . duration or character of the exposure within.the chamber . that day; d. Any. error of sampling or of other behavior, any loss of sample, or failure to obtain One; e. Any illness which influenced samples or .perrorman.ce, such as a cold, a digestive upset or any other physical. ' - difficulty. ' ... i .' ' (This is. a confidential record, which will not be seen except by , : designated persons, nor used in such manner as to embarrass or penalize the subject. It provides certain highly necessary experimental.data and should not be taken lightly.)