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The Lancet, October 5, 1974 page 348
PROPORTIONAL MORTALITY AMONG VINYL-CHLORIDE WORKERS
Sir,---As indicated oy Purchase and Williamson (Sept. 7, p. 591) it is desirable in studies of mortality and propor tional mortality to compare disease-rates in a study group with those from a similar community. Hcwcvrr, tabula tions of deaths in the United States arc not available in sullicicnt detail by age, time, sex, race, and cause to permit county-specific or, for many diseases, State-specific
comparisons.
A recent publication is an invaluable aid in assessing the degree of bias lively to be introduced by using national data.1 Average annual agc-adjustctl cancer-mortality rates per 100,000 for White males in Jcifcrson County, Kentucky, where Louisviile is situated, compared with rates for the United States (in parentheses) are: biliary passages and liver 5-5 (5-2), primary and secondary trachea, bronchus, and lung 43-9 (3S-0), brain and other parts of central nervous system 4 3 (4 4), all mndgnan: r.ecpiaam: 1310 (174-0). Also, mortality in 19ou tor ati causes tor Kentucky White males' is similar to that for United States White males 1--973-6 (956-2). There is no indication in these data that use of proportional mortality for United States White males could account for the observed/expected ratios reported in our paper (Aug. 17, p. 397).
Department of Epidemiology, Harvard School of Public Health.
677 Huntincton Avenue, Boston, Massachusetts 02115,
U.S.A.
Richard R. Monson.
}., e.1. Mason, T. McKay, W. U.S. Cancer Mortality by County:
1950-69. Department of Health, Education and Welfare Publica
tion no. (K.I.H.) 74-0!5. Washi""TM. >74
- Crete, T- C,,
A. M, V::c! Strtiteic: !*"- in tb* VnimJ
States; 1940-60. Public Health Service publication no. 1677.
Washington, 196$.
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TRAT'IAMl..VI I
ANIM All (T 01*1 Swiss;
Traltnli
Snpr.'t vvi-.suii
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A N 1 M A 1. 1 con rr.MOKi
Adciioini Adi m>- [ Anjpoc ndcim- raiemniiii carcimmii della | sareumi
(Id mam- 1 dd polmow im lla l" fi-^ato
-- -/Vr'
Aim tipi v.ju
locnliz-
ziizintii
Tnlale 0)
S v Tfilalt- * V Tol.ik-
N.
N.
N.
N. N. '
1) CV 10.000 ppm ,w 30 -
II) CV 6.000 ppm 30 30 Oo
III) CV 2.500 ppm 30 30 60
IV) CV 500 ppm 30 3 60
V) CV 250 ppm
30 30 (0
VI) CVsoppm
30 30 60
VII) Nessun trnttaniento .... 80 70 150
8 iS 26
I 21 32
>3 24 M 26
37 40
=3 21 44 lG 20 42
61 61 122
12 12
6
8 4 --
--
_V 5 3< 13
4
i3
2 (S) J3
2 - ? -- 6 /3
1
2y
--
2 . _3 --
9 /? 5
1
-*
--
Ir
(--
-a
--
---
Totalc . . . 260 250 510 146 197 343
42
15
3 (7
S
47
(]) Ncllc feminine. (2) 1 carcinoma squamocdliilare, 1 chcratoacantoma e I cin.nipiomn della cult*. (3) 1 linfusarcoma tiinico, 1 carcinoma nasopnrictnlc, (4) Diversi animali con due 0 piu tuinori.
IT
A nostra cpnosccnza sul rat to non sono mni stati riportali ndroblastomi c angiosarcomi cpatici spontanei.
I ndroblastomi non sono mai stati provocati speri mental monte. Angiosarcomi cpatici sono mai stati intlotti spcrimenialim-nte ncl ratto con diclilniuosaniina .'RcuIkt c Ia-c, 196S; lladjiolov, 1972). Nd topo angiosarcomi cpatici eel cxtracpalici sono stati indolti con o-aminoazotoluene (Amlervont e coll., 1942; Andrrvont, 1950) e con />-dimentilaminobcnzcnc-i--azn 2 naflalcnc 'Mulav e SaNen, 1953), e con allri agent i tra cui uretano, dietilniirosamina, dimctilnitrosamina c dime!ilidrazina. Nd coniglio angiosarcomi sono stati provocati con thorutrast (Zeitllmfer c SjxiisiT, 1954 . Ndl'noino g)i angiosarcoini sono rari. J.anddls nd 1958, faeendo il pnntn sidla sitnazione degli angiosarcomi de.-.erilti in lellcralnra, nc raccoglieva 117 casi, tli cni solo 21 epatici. k.ssi perb sembrano andarc amnentando in ipusii ultimi tempi.
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l.ineri - Kcnd. Si:. fi>. mat. < nal. Ynl. IA'1 marzn 1974
Nflli* Talx-llr II VI vi-ngoiin I'spiKti i duli prcliminari rclativi ngli cspcriinonli MTi, HT3, H'i'fi, I5T 5, HT.p Per tjuanlo ruix'cmr gli allri cspcrimriiti dolihiamo xllciultTr aix'nra j>t*r nvcrr risullali.
J)a rpiantu piVM-ntaln ncllr Talx-llc dallo studio islologiro omtTgono i
scguonli pimli: l) il C\- v oix'ogrno nolle condi/ioni spcrimontali da noi sagjjialo: csso
provoca cumnnmj ddle gliiaixlolc di Zymlial (fig. i), ncfroldnstomi (fig. 2)
c angiosnrcoini cpatici (figg. 3, -0 o di allri tessuti cd organi (figg. 5, 6) ncl
rattn, c adcnomi adcnocarcinomi polmonari, rarcinomi mammarii c angiosar* conii cpatici ncl topo;
Grltpt
TRATTAMUNTI
Tabklla II
{
Espn inicuto BT r. Kisultnli spcrhncvtali a Jjo st'ttimavc
Aximai.i (RATTI Sl'RAGCK-
IJAXVLEY)
A X III A l 1 COS Tl'MOAI
Totali-
Sopruvvi&btiti
Carcinomi dcllr Ncfrophiandolr blnriiomi
di Zymbal (A)
(U)
Angiosarcomi
Frgato (C)
Altre local izzazioni
Altri tipi c/o
local izzazioni
Tot ale (0)
N. N. N. N. N. N.
I) AV 2.500 ppm 11) CV 10.000 ppm III) CV 6.000 ppm IV) CV 2.500 ppm V) CV 500 ppm VI) CV 250 ppm VII) CV >0 ppm
VIII) NrsNim Irattamemo . . .
96 69 72 74 67 67 64
68
totai.k ...
577
--
-- -- -- --
10 30
16
77
1
3 -- ---
10 /
S)
* 28
--
4 AT 47 6 4 6 l
>3 14 (3
7 4 /
---- 34 45
__ ___
-- 6 (H) 35
2 (D)
I 0)
24
3 (E)
1 (L) 24
2 (F)
. (M) 16
2 (G)
3 (N) 12 /c
_ // ^A7'3rfie `'J
-- /. --
9 M iK
A) Mrlaitasi al | ml mi mr. IJ', Mi-lasta-a al frgatn r/n al pnlniniir r alia liiil/.a. (') Mrtasta*i al pnbnimc. D) I aii;'i"'4ii'*niia anj'iiniia (iliin-aiix- >r>tti.riiiniii-n; l aupiii'arromn imilimiili- auricolarr. K) 2 ;iit;;i<i *i11i intiailil.initnali ;i tiriim alia mil/.a. I vn inn nH'inaiiO; I ni>;:i"*alciima (ivvilii'anlr InX-im ri \ it air. I-; i aii-in,.iii intis pnliiniiiarr; l angin--aii nma ilrll'titim. C) | anpinsarriinia iniiailttuhiinalr \iriim alia mil/a'; I alicitisarrniiia (..ifirauir intialmacii'fi. Ill 2 ailiniiMii (Irllr glilaliilnlr ili /initial; I nrurilriiihnihin drl padij.'liiinr am n ularr; 2 eateiiitimi mahihiani; I l isliiaili niM aii'iniiina il' ll'in.iiu. I) | carritmtiin srli.ii en della tile. I.) ) adrnninn drill "hinndnle di Zyndial. M, I rpaimiia a niiniiiia d' \ ia/nnn . \; | ailrtumia il.-llr ;;liianiluli- di /vndial; I car* riinima di Hr ;;lii.'milnlr '.alivaii. (1 ] > I \ i r-.i aiiiinali run ilur u pi it tiiliniii.
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