Document jmYpJ6xYV18352OeZ3oJoezy2

The next major question in the mechanism of the action of asbestos dust is its interaction with the cells or the organism. It has been established that even the long asbestos particles are absorbed by one or several macrophages (VigMani, Pernls, 196*1). In this case the authors did not reveal substantial chanr.es in the macrophages. According to our observations in conjunction with A. A. Gerasimenko (1966), during the introduction of chrysotile- asbestos into the peritoneum of white mice the number of morpho logically changed and, probably, denatured macrophages is for certain 2 times higher than during the introduction of coal dust. There is reason to believe that the damage of macrophages can trigger a complex chain of immuniological reactions. Both our works (F. M. Kogan, A. A. Gerasimenko, 0. I. Bunimovich, 1967) and .observations of Z. S. Repnitskaya, 1967, N. T. Butkin and M. V. May, Medeka, I960, Gamblnl, 1961, etc., testify to this. However, In this article we do not analyze the immunological aspects of the problem of the action of asbestos, but only focus our attention on the fate of macrophages. ^ unction with ,A.:;P/ii>arinovskaya (1966) we succeeded in showing that under the effect of chrysotlle-asbestos (and to , a somdwhat lesser degree serpentine)., in twenty-four hours the . ' growth of cells and their migration In the organ'culture of the lungs, of the human embryo is retarded. ;.V' .`examine these fibroblasts as a phase of evolution of the mac'rophage. In this connection we must give special attention.............. to thj fact that the same Vigllanl and PerniB (196*1), denying thie' cytotoxic action of asbestos, established that in the culture of fibroblasts which contacted with asbestos, the collagen content In albumin Is 2 times higher than in controls. * .. 1*1 6000 0877 PRODUCED BY FORD