Document jm9DyRGQoR1jvobnEj0YX5BDy

9 May 1983 t CORPORATE ^trrv DOW CHEMICAL U.S.A. MIDLAND, MICHIGAN 48640 Dr. Z. G. Bell, Jr., PPG Dr. W. Clark Cooper Dr. W. Gaffey, Monsanto Dr. V. E. Kirkland, Shell Dr. R. W. Laundrie, General Tire Dr. C. Stack, CMA Dr. I. Tabershaw Dr. C. Tamburo, U. of Louisville Dr. 0. Wong, EHA ANGIOSARCOMA REGISTRY Dr. John Stafford has again supplied an update of-the angiosarcoma registry which he has maintained for several years. As indicated by John, this is his last since he retires August 31. I am sure you share my gratitude to John for his work and are delighted that Dr. Brian Bennett will be assuming responsibility. I trust you will give Dr. Bennett all the cooperation you can. It is currently our expectation that Dr. Bennett will visit the U.S. this summer, but plans are not yet firm. We would like to have him schedule his visit to coincide with our CMA meeting on the Environmental Health update. Carol Stack and I are hoping to have this meeting in July or August but cannot make definite plans yet. At that time, I would like to turn the vinyl chloride projects over to a new chairman. Sincerely yours. T. R. Torkelson, Sc.D. Toxicology/Medical Liaison Health & Environmental Sciences 1803 Building 517/636-5197 9 Enclosure cc: Dr. John Stafford/Dr. B. Bennett, ICI AN OPERATING UNIT OF THE DOW CHEMICAL COMPANY RECEIVED MAY 1- 1983 K. W. Laundrie G'ENC 000744 Liver Angiosarcoma Cases Circulatlon Dr K S Williamson Dr C K Faddle Hr John York, Kverberg Hr i G Davies, Bverberg Hr P N Anderson, Hilton Hr 11 ft Jervis, Millhank Hr Harold Clayton, Norsk Hydro Dr I W Williams, Norsk Hydro Dr J T Carter, BP Dr F Lewis, CIA Dr .1 P Loloine, Sotvay Hr J Janvert, Chloe Chimle, Faria Dr Renzo Hattlusal, Hontedison Dr S Pagllalunga - Montedison Hr Lolivler, Solvay Hr F G Clans, APHB Dr W Tordolr, Shell Hr S 0 Uejdllng, Komanord Dr David Byren, Kemanord Dr K Tliiis - Evenaen, Norsk Kydro Hr P Rangnea, Norsk Hydro Dr B Terwlesch, CHIl Hr II Emminger, VKE Dr J tfhlston, Iftllhouse Dr Brian Bennett, Hllihouse (20 copies - ICIA, AECI, Dr Peter Wright, PAP Wilton Dr F V Best, Everberg Hr C Cells, HontepolImeri Hr C Dupont, APME ^- Dr C Bishop, EHAS Hr J Hodgson, EHAS Dr R Splrtas - NCI/NU1 BSTHESDA Dr E W Da-ey - NIOSH, Cinclnattl Dr R Owen - TUC Dr J Stafford (10) Dr John 0*Sullivan, Hond Dr W A Hogg - Imperial OIL Ltd, Canada Hr H Hiinot Mooton - Rio Rodsno Dr Junes Purdhnm - Canadian Centre for OHS Dr Bruce Karrh - Dupont Dr D A Levfson * St Barlholonevs Hospital, London Prof M H HacSween - Western Infirmary, Glasgow Prof W K Lelbach - University of Bonn Prof C H Tanburro - University of Louisville Duperial) JS/JT/HSO-16 PJKS7917(I20/WPX Wide II Dr Cities Tlierlault - HcClIl University Dr T R Torkelann, Dow Hr J Lawrence, SPl Dr Carol Stack, CKA Washington Hr R K Wheeler, IICC Dr A Ross Allans, Air Products Or John Barr, Air Products Dr Walter D Harris, Unlroyal Inc Dr Robert K lllnderer, BP Goodrich (Cleveland) Dr R A Krueger, BP Goodrich Dr H H Johnson, BF Goodrich Dr J Possberg, Wacker Dr J C Auhrun, PC1IK Dr H P Frledel, Berufagenoeuenschaft der chemlschen Industrie, Heidelberg Dr W Ernst, Berufsgenoasenschaft der chemlachen Indua tr1e, Nurnherg ProF Dr ThJeaa, BASF Hr Stahnecker, BASF Dr D H Ferguson, ICI Americas Hr David Burgees, ICI Americas Dr Gary Ter Hasr, Ethyl Corporation Prof. 0 Hnltonl, Bologna Dr J William Lloyd, Gsha Dr David Bryson, AG Division Hr S Nakamura, Japanese PVG Association Dr Peter Baxter, EHAS Dr A Munu, Monsanto, Brussels Dr U C Barnea Jr, Monsanto USA Dr R E Coaztonyl Jr, Teimeco Chemicals, Saddle Brook (NJ) Dr Donald W Hillman, Diamond Shamrock Dr G Kent Hatfield, Diamond Shamrock Dr Pierre Bertaxzl, Milan University Dr Dana Popper, Mount Sinai Medical Centre Sir Richard Dolt, Warden, Green College, Oxford Dr R Saraccl, larc, Lyons Dr K Hootesann, larc, Lyons Dr Henry Falk, CDC Atlanta Hr J R Wallace, Raeo Chemical, Sarnia, Canada Dr F I Lee, Victoria Hospital, Blackpool Hr 0 H J Williams, BP Barry Dr Paul H Smith, Mandough Hospital Hr Hokka, Neste Oy Hr H Chance, VCH Technical Manager, Mond Dr Banche, Dynamic Nobel, Troladorf received MAY 12 1983 R. W. Laundrie b'ENC 00874= PNFKACK ACKHflWLgnGKHEtfrS, SIGNIFICANT CHANGES AND COMMENTS 1 Thla Jb the last edition of the ASI. register which 1 shall compile, On 31 August 19ft3 1 shall he retiring fro* TCT end also severing all ay VCH connections. However T an |{l*d Lo announce that 101 lisa agreed to keep the register going and the new editor will he 1>R BRIAN BENNKTr, works medical officer at our Hlllhouse Works. 1 am very grateful to you ell for all the help, support and encouragement you have given sie over the past eight years. Will you please continue to correspond with Hr Bennett about AS!, cases and keep hln Informed so that the unique and t believe useful register will be kept going. A comprehensive register will he of great benefit to the VCH/PVC Industry and research workers in the assessments of health hmarda and the efficiency of the remedies adopted In 1974, 2 Dr Brian Bennett's address, telephone and tel cm numbers are as fnllttws: Dr ft Bennett Works Hedlcal Officer Hlllhouse Works PO Bos 3 Cleveleya Blackpool FYS 4QB ha ncs Tel: 0233 856161 Bat 332 Tel ax Hoi (Addressed to Hlllhouse Works Vis Manchester Switching Centre) 6676230 Please keep In touch with him sod notify him promptly of airy new ASI. casee. 3 Prof Carlo Tsmburro of l*aulsvt!1e University and Hr H N Johnson of B P Goodrich have been most helpful regarding VS 33 and 34, BPG'e Louisville Plant found II ASI. cases up to 1976 and then nothing until those two cases In 1982, both of which are alive. 4 The news of the death of US 31 came from Dr Darey nf NinSII In his letter of 7 March 19B3 for which 1 am grateful* 5 In addition, I thank Hr'0 H J Williams of BP for prompt notification of UK 09. Also for drawing my attention to a curious case described In the British Journal of Industrial Medicine 19B3 Vol 40 pp 113-4, This reports an ASL case in a metal scrap merchant who recovered metal by burning Inter alls "plastic" covered copper cable. The scrap merchant was almost certain!y exposed to arsenic and copper but his exposure to VCM Is prohiematleal, I have not Included this scrap merchant In the list of cases attributable to VCH because I doubt whether he was ever exposed to VCH. None of the IIKf PVC producers has any record nf supplying PV0 to the alleged PVO fabricator next the scrap yard. Indeed this fabricator does mainly Injection moulding of polyethylene, polystyrene and pulypropylens and very rarely uses PVC. 6 Dr S Pagllalunga wrote on 13 February 1983 and gave ns a copy nf a paper by CHIAI'PINO et al In Hed Lavoro Vol 6 (1992) pp 53-363 which describes Italian Case 04 In detail. Thank you Dr PagUslunga for this help. 7 1 am grateful to Dr Walter Harris of Unlroysl for bis letter of 1 September I9A2 giving me accurate data about the history of VnJroysl and Atlled Chemical PVC plnnts at Pafncavtlle, H, Hie IJnlroynl plant was closed in 1 973. The Allied plant was sold to Bnhlntcch who In turn sold It to Georgia Pacific who senmed to convert the plant to maka polystyrene. The change* In ownership of plants and their closures are confusing. There are major pieces of restructuring going on'In the PVC Industry In many countries and It Is now difficult to know how to describe cases, eg 1CI has acquired HP's PVC Imalnetu* but BP has shutdown Its old Burry 6 Dag]no Bay KVC plants snd transferred to IC1 only the moat modern PVC facility started up st Barry In 1981/2* The newest 1)K esse G9 and all the other BP rases are all men who worked In the old Barry P5 building prior to 1974, 1 have left theae cases as BP Barry cases. 9 I have elaborated Table 4 even further In a tedious, mechanical way to highlight some of tho peculiarities of latency periods. The HCG South Charleston latencies are uniquely Interesting as Is shown In Tables 4g ami 4p, 9 1 should like In record my thanks lo Prof W K l.ethsch, Burnt University (nr useful discussions nod for Introducing me to the comprehensive monograph on 'Vinyl Chloride Associated Disease* by Lelhsch and Karstolter published hy Sprlnger-Vertsg In 1981. John Stafford n April \m GENC 008746 / IMPERIAL CHEMICAL INDUSTRIES PLC PETROCHEMICALS AND PLASTICS DIVISION LIVER ANGIOSARCOMA CASES (REVIEW DATE - 15 APRIL 1983) Table Sequence Belgium Canada CzechoBlovakia Fcance Germany Italy Japan Norway Sweden UK USA Yugoslavia Incidence of Cases pa (Table 1) 1 2-3 4 5-7 8-12 13 14 15 16 17-19 20-25 26 27 ASL Case Numbers by year of Death (Table 6) ASL Case Numbers by year of first exposure (Table 7) Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8) USA PVC Producers - Start-up Dates vs ASL Cases (Table 9) Canadian PVC Producers - Start-up Dates vs ASL Cases (Table 10) East European PVC Producers - Start-up Dates vs ASL Cases (Table 11) Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12) South & Central American PVC Producers - Start-Up Dates (Table 13) Distribution of Cases by Country (Table 2) Pattern of Cases by Factory (Table 3) Latency Periods (Table 4A) Distribution of Latency Periods (Table 4B-411) Annual Geographical Incidence i,' 28 29 30 31-7 30 39 40 41 42 44 45 46 47 GENC 008747 IMPERIAL CttKM fOAi- INDUSTRIES HLC PETROCHEMICALS AND ELASTICS DIVISION IVKK Aii){ioi}drcoM;i Critic* - (Review flute: 15 April I9H3) Page l KT AMI HENCE 21 NAME OH INITIALS date up AIKTU __ 12.01.n Solvay __________ .......................... i- y ikirr vc EXPOSURE DATE UK DIAGNOSIS ____ AUK AT OfAHNOS IS Jeaeppti nn.o? .sa 00.ns.76 63 1 .. 10 U TEAKS OK EXl'OSURE TO 1)1 ACNOS IS TEAKS OK EXPOSURE OATK OK DEATH 1 H 17 29.06.76 i i i i t i i i i i 12 HISTOLOGICAL CONKIRKATION Tea 11 1 13 1 * 1 15 1 lb 11 11 ESTIMATED 1 \ EXPOSURE | OCCUPATION | IJIVEL i | OTIIEK CAREER HlCJM.ICItTS 1 1 1 | 1 OTHER COMMENTS i1 1i 1i 1 i i Hl*h Ii i | Autoeleaner JOrlll.f n . IH.p.tlc te.t. in yr. 1958-1968 I expoaed tot Polyworker 2ou p|M 11 yr. for A lira 1 par day t and 1 cartelnly 1 under 500 PJH* 1 t In 6 to 9* 1 1 autoclevea 196B-1972 1 axpoaerf to/ 50-200 pp 1 A hr* par 1 d.y In 15J 1 1 autncl areal 1971-197* aapoaad to| 50*200 ppaj In auto* 1 clave roont 1974-100 1 ppn 1 1975- 50 1 PPB 1 RETIRED 1 1 Feb 1975J |foundry Itl yr.) |Paraer 105 yr.) (Work In glaaa llfid. 1 che*l~ |cal Induatry i t i t s 1 1 1 1 1 1 1 1 1 1 1 1 t 1 1 t 1 1 tin Oct 197* )were no ratal. Jftetlred |Feb 1975 IHoapltalIaed IHay 1976 I |Complete |Cllnlcal and jcareer detatlal |are given In t |paper by tllublec at at |ln Arch. Belg fMed. Soc.t IHy*. Med. |Trav, Med. ILeg. (1977 pagea t601-622 t i t i i i i i | i i 11 i 11 i 1 1 II i 1t i 11 i 11 i 1t i 11 i 11 J i i GENC 008748 i' imperial chemical inihistktks plg PETROCHEMICALS AND f LAHTI CS DIVISION LIVER Angl oaarcoma Caaes - (Review Date 5 April 1983) All dates uee UK eyatem Canada DAY - MONTH - YEAR Sheet 1 ** Data published In Journal of Occ Med 197B pages 33B-J40 *** Many of dates altered to fit HIOSII 31/3/77 Hat Page 2 1 11 1 l2 ia1 I ii 1 ii iNrjtY ANU 1 NAME OH | DATE OR [ KEKENCE INITIALS | H IKTIt | A COMPANY 1I 1 f516 t 7 1 I _L i i I FIRST VC OATH OF 1 FACTORY 1 EXPOSURE 1 DIAGNOSIS NO ADA 01 1)2 1 1 i i 1 1 i i_ l l 1 1 !1 11 11 11 11 115 *12.13 | ii ii ii lufi.m.n t ii ii i i J SIIAWINITJAN 1 i i i i i l1 1 l1 II 1 mt 1955 tl I1 tl l 1941 I 1957 lI tl I 1 03 1 1 I 1 i 04 i i i 1 ij 1J J26.06.I9 1 t 1 1 1 I05.nt.l9 1 1 1 1 1 11 11 11 1 il l i I 1 94 1 I 1962 iI I 1I 11 il I i I J 945 I 1967 il I iI I it t i i 05 1 1 i 11 11 107*05.11 | ii ii I1 i t Ai I 1944 1 L96B 1l 1 il 1 i i 06 i i .1_____ _L_ tt 1l iI 1 11S.I1.19 | i l 1947 1 1971 11 iI 1 i 11 iI 1 i.........................1.....-..... . -.1 . .... ..L ... . _L 1 11 1l 1 07 1 |09.LI*]9 | l I 1 946 1 1972 .. 00 i i L. 1 I l ti ii ,L._ ____! . II in.ns.in i ii II 1 11 1 .L I1 1 t I 1961 l 1971 Il l _L _ 1 09 l I l I 1I 11 119.07,21 | ii ii 1............_. L 1l l l l 1946 l 1974 II l l1 I .. L 1 B ACE AT OJACNOStS 41 43 42 4B 57 51 53 51 53 t1 9 i in 1 11 ! 11 YEARS OF l YEARS OF | DATE OF EXPOSURE TD l EXPOSURE | DEATH diagnosis 1 t .1 i 1t ti 11 l 1 1 t 14 t 1 1 1 1 21 l l l f 22 1 l . l 1 24 1 l l 1 1 24 1 l 26 l 1 1 l 12 l 1 I 1 2B 1 1 1 n 102.09.55 i i i (4 121.12.57 1 1 1 1 20 123.03.62 i i t 1 22 121.01.68 i i i i i 05 |05.07*68 i i i 1 21 |10.04*71 i i i i 25 124.12.72 1 1 J 1 05 112.06.73 i i i 26 |r>4.09.74 1 1 12 HISTOLOGICAL CONFIRMATION Yes Yes Yes Tee Yea Yea Yes Yea Yes i n 1 14 1 1 1 ESTIMATED 1 | EXPOSURE | OCCUPATION | LEV EL i ( i i 13 OTHER CAREER HIGHLIGHTS ! | J 16 OTHER COMMENTS |Reactor (cleaner |Operator (Smoker (polymerleat ton) i ji 1 (Maintenance, (Operator |Worked |*H Ivrl ght, (overtime | pipefitter 1 Smoker i 1 (Operator, ]foreman i i I Worked lovertime (Non-emoker l 1 Reactor (cleaner i | | (Operator, (foreman. (water cooling limit I Worked lovertime |Smoker i (Reactor (cleaner ! IVater cooling |Worked (unit (overtime (Smoker 1 1 1 1 1 | Reactor (Maintenance, |Uorked 1 *! |cleaner (millwright (overtime 1 i | Smoker i - 1 (Reactor IMachlne ahop |Worked Ideaner (operator and lovertime i Ipoly unit ]Smoker i 1 (Reactor (Maintenance (In plant (cleaner (machine ahop 125 yral Smoker i 1 (Furnace op. IplpefJ tter 1Maintenance |Worked (overtime (Smoker juir hy Dr I' DELORME lu Anmilea d'Amitumlti pullmlng hpiu I'jirlrt, 19711 Vol 21 Nu 2 p|i|05**M4 clulitui this iiiijio IijkJ bulb a liupntnna Slid A HI* slmultanuonuty GENC 00374? OIIHTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH 16.05.15 IMPERIAL CHEMICAL INDUSTRIES PLC PETROCHEMICALS AND PLASTICS 111 V15 CON T.tVER AriRinaarcomn Caaea - (Revinw Hatet 15 April 1983) DAY - MONTH - YEAR She tit 2 * All date* uae HR ayeten Canada ** Data puhllelied In Imirnal of Occ Hed 1978 page* 318-340 *** Many of date* altered to fit NI0SI1 31/1/77 llac FACTORY FIRST VC EXPOSURE DATE OF MACHOS rs L ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIACNOSTS YEARS OF EXPOSURE -1 DATE OF DEATH HISTOLOGICAL CONFIRMATION 13 ESTIMATED EXPOSURE LEVEL 14 OCCUPATION IS OTHER CAREER HIGHLIGHTS Pfljl* 3 16 other COMMENTS 1953 1976 Ofl.H4.77 Reactor cleaner furnace op. nalntenance t rmckafllng Sx-awoker _____ 1....... _.J____ ____ LI____ ____L J. .... ...L 6ENC 008750 IMPERIAL CHEMICAL INDUSTRIES Pl.C PETROCHEMICALS AND PLASTICS 11 VISTOH I.IVF.R Anftlonarcoma Cases - (Review Dn et 15 April 1901) Page 4 I 12 11 'OUNTRY AND REFERENCE NO NAME OX INITIALS DATE OF MKTII 26.06.2ft FIRST VC EXPOSURE DATE OF DIALHOSTS ACE AT DIAGNOSIS TEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE OATS OP HEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER IHCIIU Cl ITS OTtl RA COMMENTS Novaky 01.07.57 24.12.71 45 16 16 24.12.71 Yea Autoclave Cleaner IARC letter nf 1-4-R2 giving details fro* Prof A David of Centre lnd Hygiene and Occ diseases* 02 06,07.27 State Co Nnvaky 01.11.50 27.11.64 37 14 26.11.64 _.lI Autoclave Cleaner IARC letter of 1-4-R2 gave onevhat altered datea for tMa cate, f have accepted the changes a luce the date* cone Cron Prof A David of the Centre of Industrial Hygiene and Occupntlonal Diseases. My dates cone orlglnally Iron NIOSII. GENC 008751 ZKI*KHIA-tj. CHEMICAL I NIlUSTH IF./! 1*1.0 PETROCHEMICALS ANI1 PLASTICS DIVISION LIVER Anglnunrconn Caaea - (Review Date! IS April 1441) France SJlL_L Page 5 1 Ii 11 1 i ` 12 | 1i ^ 151 6 1 7 i8 1 9 11 1 1 1 16 ! 10 1 11 1 i2 i n 1 >4 J 15 1i 11 1 1 _L 11 i1 1 1[ 1 1i fTKT AND | NAUR OR | DATE OF i ii 1 t 1 11 i i i FIRST VC 1 DATE OF ACE AT | YEARS OF YP.ARS OF | DATE OE | HISTOLOGICAL 1 ESTIMATED t | OTHER | OTHER 1 'EHENCE | INITIALS | A1 Rill | COMPANY | FACTORY | EXPOSURE 1 DIAGNOSIS i DIAGNOSIS I EXPOSURE TO EXPOSURE | DEATH | CONFIRMATION | EXPOSURE | OCCUPATION t CAREER J COMMENTS | NO i ii ii 1 i t DIAGNOSIS t ii I1 1 t t 1| I1 1 t.EVRI. 1i 1 highlights j 1 ] i it 11 1 i ICE i !i 11 1 i i ii ii l 1 1 ii 1 ii (U |W U5.tl4.24 | RP (Rouse- \ 00.01.46 1 lft.02.67 43 1 21 19 J19,02,fi7 | Yes | High |Autoclave 1 JI (Ref. Aavler et) i ii i 1 lion 1 1 i i ii i (worker and 1 |at Arch. Hal. 1 i 1i ii 1 1 ii i Icleaner 1 (Prof. 1 3H ,,' | 1 11 ii 1 i 1t i 119 jrr. 1 |3 Kov 75 | i ii ii 1 i i i it i 1 |p 171-177 1 ii ii 1 i _L i i i 1 l 02 fSlM 11 im.o6.it | VCMK 11 1 i IRrlgnourf | 06.07,59 t 15.ni.75 r 63 1 16 I 1I 12 124.01.75 1 Yea 11 | III Eh |2 yra on |1tat fan fRef* | i ii ii 1 i I i i (NHISII nn 1 Jmonomer |nrl*ln |C Ronneton et 1 i ii ti 1 t i I t i comment) \ til) yra nn 1 (at "Nouvelle | 1 ii ii 1 i i 1 ii ii 1 i I ii 1 ti t Ipntymer- 1 i | laatIon 1 Ipreeee |medleale" l J i ii 11 1 1 t ii t 1 15 Nov 1977 | l ii ii 1 t r 1| 1 1 Jr> 735 | l 1 01 JNAV _1_ A \1 [06.01.20 J RP it A. 1 i 11 1 t r |St font t 00.00.A6 1 15.nt.75 55 | 29 1 11 1 1t 1 29 I29.0fi.75 | Yea 1t 1 11l | High | Polyworker |VCM production!Ref. Rety et \ i ii ti 1 i i l it i |in yra aa 116 rr let Arch. Mai. | i it ii 1 i 1 ii 1 | autoclnve (Italian POW tProf. 1 37 n* 1 i 1i ti 1 t f ii 1 | cleaner |Shepherd, 16 June 77 | i ii ii ti 1 ii 1 1 Compounding 1 Sawyer* Mnaon Ip MI-555 | 1 li 1 1A ii 1 t J |i 1 i t i 13 yra i 1 ii i i 1 | J ]04 |KOR i1 127.01.27 | PCUK 11 1 IRrlgnoud | L9.lO.49 1 ifi.nt.76 i 49 1 26 1 11 1 26 |04.01.76 | Yea 1 1 High JMonomer i i i 1i ii 1 I i I ii | product Ion i | | I 1i ii 1 i t i 1i ii 1 t t 1 it I ii i |worker i i |fl yrs i J1 |{ i 1i ii 1 i I ti i JPVC i | | 1 1i ii 1 tt 1 it i Ifiltratlon i 11 i 1i ii l i i j it i 1 Ifl yra i 1 05 | R i 1i 11 I29.0t.34 1 point i1 ii ! 11 fflrJgnoud | 18.ni.65 1 13.05.76 ii 1 i i i in i 1 1 i H I 11 l ,, 111.06.76 | | it Yea i11 1 111 1 High (Polyvorker |1)Thoracotomy |Ref. P Couiterel i |M yt. |9th r.b 1976 let at MSemaIne| i i1 ii 1 i i l ii i Icoatal Idea hoepltaw* 1 i i1 ii 1 i i i1 ii 1 i i | it 1 ii i i (anglonarcoma |10 Septemhre | |2)Sc!ntlgrnphy|1976 J i i1 ii 1 i i J ii i |Found ASL fPrevImnly had( i i1 ii 1 i i I ii i |3)Haennrrhage |hona I i i1 ti 1 i i l ti i |from ASL | angtnaarcona" 1 i i1 ii 1 i i | ii i lOBIdht |A1ao | i i1 ii 1 i i I ii i f llopatectony IPJtirbowsVl et) i i1 ii 1 i I ti i i |al "La Nnuvelle t ii ii 1 i 1 l ii t i IPrnaae Medicate i _____ A i1 ii 1 | .1____________1___________ ,,..L__________ 1 .... .......... ........L .... ... ... .1 i 1t .......... ..i............................. ........ ... ,, , I ii i | ....................... ....... j______________ 1........................... A- ..... 17th ,lu!r 1979 | ir.fln 7<nj i 6EMC 003752 1 Hl'KRtAL CHEMICAL INDUSTRIES p|.C I'ETKOCIIKKTCAI.S ANFJ PLASTICS DIVISION LIVER AjiRtnaarcnma Caaea - (Review Datef 15 April 1983) France Sheet 2 fane 6 |1 2 i 13 COUNTRY AND Ji| 1 1 NAME OR t DATE OF REFERENCE | I KITE A1.S 1 MftTft NO i i FRANCE i i i i 1 1 (16 | fa 11 4.04.34 ii ii ii ii ii ii ii ii ii J___ . j 07 | GIR i l26.Ot.2T i1 i1 i A 15 J 1 1 COMPANY l factory i t. t i i1 6 | 7 ia | 9 FIRST VC EXPOSURE l t .tL date of nracwas is I l ACK AT DIAGNOSIS 1| | YEARS OF EXPOSURE TO 1 | DIAGNOSIS I1 11 I1 PCUK |RrJgnoud ini.03.58 | I2.0S.76 1 A3 1 ie i i1 i I1 i I1 i 11 i l1 i I1 i I1 i I1 i I1 t l1 ftp 1 261 |St Atiban 01.0T.50 I After l 49 1 i i | dentli | NIOS11 I 1 i 10 1 1 11 t 12 1 YEARS OF 1| OATS OF | HISTOI-OOIGAL EXPOSURE | DEATH | CONFIRMATION i t i t n |H .09.76 1 KHIOSII Yea laaye 112.09.76: i i r i i t i 32 i103.07,76 1 Yea i | (Ninsil no 1 | comment.) 13 1 1 14 I 1 13 ESTIMATED i i | OTHER EXPOSURE | OCCUPATION | CAREER LEVFX i 1 mem.TOUTS t i r 1 Moderate f ((958-1960) 13 r. |flit ration IIO-ll yr. 1 polyworker land work* llibl 1 1 1 1 mull 1 IPlant fore- 11972-6 admin |an In Ipoly.et- |aect(on In |St Auhan ii 1 16 1 11 11 ( OTHER | | COMMENTS | ii \\ 1 1 1 |Th1a man hod |A(ll. prior to (AS. Ann. de IMal.'Prof. 1 1 1 | | 1 | l.l.il, WT | Ip 645 ( 6. | |AOL waa found | lln 1971 five I Jyra before IASI, 1 1 1 i |Died of 1 i | (septicaemia |Smalt 1Iver | 1 t1 i1 1 i 1 aaya | 00.07.76 I I 1 i 1 i 1 ieettnn i llealon found | lafter autopay | oa 1 1* i i i i t j 09 J J R FTC i i i 1 i i t t i i i i i i i i i i 1i 1 11 li I01.0t.lt SoLvay ITavaun 23.05.57 | 03.13.75 I 42 1 19 1i lt 1i Ii 1i I1 1i 1i 1i Ii _Lr|OR.tO.|4 i i j RP i 1 I .St Fona 10.01.AS | 26.OA.7fi 1l I 61 i 1 r 2s i I1 i I1 t1 it i1 il ii ii ii ii I1 II 1 11 l1 l1 tt ii ii 1 tt ii I1 it 1t ii l1 ii 1 ii l1 ii l1 1 19 130.01.77 | i i 1 i i i 2fl i II5.L2.TT 1 1 1 1 1 1 t 1 t 1 1 1 1 1 1 1 | t 1 Yea Tea Moderate Very High 1940-1966 T.eaaer Exposure 1966-1976 i 1 |6 yra packer| |6 autoclave Jclnr 116 rr. (autoclave |worker 1 1 |Polymer| laatIon (operator, (autocleaner laiitnclnve (maintenance ||0 yra In (mil plmH c jacM factory, letorekeeper 6 (general laervlcee i i i t i i i i t i i i i 11 ii |Uad been \ 1(tunnel worker (pteviouely E 11 ti ii it I (Operated 4,76 1 | ||for removal of 1(tumour from (liver and 1 (died after 1 leecomt 1 (surgical 1 j(operation for JhHlo I (bronchial 1 1If atula [ IPaper by 1 | lDr Rety ec al 11n Archlvoe de| IHiladna 1 aI Profcaalonel 1 6 1IVol tO No 11??* p*e* 1 fltl-J. .!____ i i_______.1. .. _i --. ___-L______ . -L ______ _.1______ ___ !............. L_____ J ......______ .1. _______ -L -- ........ GENC 008753 imperrai. :iiKHrrAi. industries no ETKOOlfEHtOAl.S AND PLASTICS DIVISION LIVER Aitftlnaarcomn Caunti ~ (Review Oate: IS April 19A1) Trance Sheet) Yhr* 7 l |2 |1| 1 11 1 \\ }UNTKY AND \ NAME OK | DATE OK | INFERENCE | INITIALS J BIRTH | m> 1 l 1I 11 ;ancc i i ti ii A COMPANY 1I i 1 i 11 Ii i t5 l6 1 7 t 8 1 9 i in 1 N 1 12 1 13 1 14 1 11 i !. j.. t 11 1 1t 1 1 1 i 11 l1 1 1 I FIRST VC J DATE OF I ACE AT l YEARS OF i YEARS OK | DATE OF 1 IIIST0LIXS1CAI. L KSTIHATED 1 | | FACTORY 1 EXPOSURE | DIACNOSLS | IHACNOSrS l EXPOSURE TO i EXPOSURE | DEATH 1 CONFIRMATION | EXPOSURE | OCCUPATION | i1 i t | DIAGNOSIS i i1 i LEVEI*' i | t! i _______ i f i i1 ii 1 t1 i i t i it ii i tl i i i i1 ii i is OTHER CAREER 11ICULTCUTS i 1 1 r | | i i i i 18 OTHER COMMENTS LO |VP i i i i i J ] II. 1 1 1 1 1 J 1 1 1 1 1 1 1 1 1 1 1 1! t 1 1 1 1 1J 1 1 1 1 1 1 I 1 1 1 1 |j IHt | | 1 t 1 12 4.05.19 | RP |St Pone l 00.12.56 J 10.01.78 1 ii ii it ii ii 11 5.02.12 | RP i i i i i fSt Fona 1i l l1 li li l Of). 01. AI | I2.0fl.7fl 1 | 1 1 1 i 11 jI i i 11 11 11 il il iI i i i i 1 1 11 iI i i 11 11 t1 iI 1 i 1 | 11 il i 1 11 11 iI il i i 1 1 11 11 i1 i1 t i i I 11 t| 11 il i i t 1 A- - i i1 i i 11 tl i i 11 (U.oa.H | rciiK 1 .L i | Hrl gmmd 1 09.02^59 | 00.ns.29 i 11 i1 t 1 11 11 tl t1 l 1 1 1 11 119.01.11 | Solvay i ITavaux 11 1 21*09.61 | 28,00.99 I i1 11 il i1 1 1 i i 11 it 1 t 11 t1 iI il 1 1 i i 11 11 iI I1 1 | t i 11 1 1i 11 i 11 (Of-oT-24 t Chine i I St Fona | | Chi ale 1 | | (Formtrly i t l l I mi l j l on.07.AI 1 1 L 1 t | 1 1 RP) i l 11 il t 1 i | 11 iI 1 1 -L .. I A .................. !. 58 1 i t i i i 66 1 i I i 1 i i i i i i i i 1 i i i os I i i i 40 57 ________ 1 i 1 1 1 i 1 f 1 i i | 1 1 i i i i 21 37 10 16 Ifl i 21 |L0.0I.7B 1 ii i i1 t i1 i i1 t i1 i M m.n .78 t i 11 i1 i1 t t1 i1 it 11 i 11 i 11 tI i 11 t 11 i 11 t 11 i 11 i 11 i 11 i 27 121.08.79 1 i 11 i 11 i 11 i i 11 122.08.7? 1 t 11 1 11 t 11 i 11 i I1 1 11 1 11 t 11 i i i 16 t 1 1 I (29,07.01 t 1 L I I I t 1l 1 1I t 1I i J... .. - l Yes Yea Yes Yes You | nigh [Autoclave |tO yra In |Died of i letenner lMechanical Ipulnonery ii l engineering, (embolia* 5 ii ii |1ndnatry 11946-1956 Ida*a after | anrgery i | nigi) |l941-175* * t 1 i i f polymer- i i i J J net Ion i t ) gene ml i t i l purpose t i i {worker i i 11948-1972 | i |VCM i i jsvntlieal i i Unci t i t |Aeety1cne) t i i i i i i | Fo reus it t i i l(l!t nt i i i Ide nsltrlse)! i |T?T2 i i i i 1 retired i t i1 i i i1 i | 111*0 1Monomer i i t i |product Ion i [sort polpoer"| i t i I teat ton i i lope rat or j i 1 lAtitocleaper |2 yra aa cyelelCigarette i 12 yre, i | Am to-- 1 luperator i |9 yre, i |Copolymera i (4 yre 1 *3 i1 i1 .1___ _ , | Very lllflh lilTi-nTT I Meehan 1c. |10 yra aa Jenamel1er In (aanltary ware |Manufacture i i i i (T975-i9JI (amoVer until 11 974 . IU al 1 | lf 1977 due rnf lOeniphageal | varices. ISurglcel J1 intervention 125.05.79 1 (right | hepatectony) i i t 981--1975 [AIL types of laalnt euance i and ||nba on |wnrk t fntefaltr - | annul act lire i i ent 1 y J4 Maintenance i 1975-1979 11 fi VCH Poly i | fProceaa | i i i i i t GENC 008754 IMPERIAL CHEHICAL INDUSTRIES PLC FETKDI'IIEMICAI.S AND ELASTICS DIVISION LIVER A:igf nnarcona Cnees - (Review Date* April 1933) Gernany Sheet I Pane A 1UNTAY AND REFERENCE NO NAME OR INITIALS DATS OP MATH <10.00.30 Dynaalt 02 00.00.31 Oynoatt H0.00.30 Dynaal t 0I>.<10.30 _L__________ L. FACTORY FIRST VC EXPOSURE OATS OF DIAGNOSIS, Trotedorf 01.10.36 I9.09.6S Trolarforf 14.10.57 25.09.70 Rhelnfel- 09.06.52 Hen 00.03.7) Ithi r g-- hanaen L______ 16.04.57 26.11 ACE AT DIAGNOSIS 39 A3 9 L.. YEARS OF EXPOSURE TO DIAGNOSIS 12 13 21 17 ii l m IH 1l ll | YEARS OF | DATE OF | |EXPOSURE DEATH 11 11 11 11 11 1 11 115.01.69 11 |1 1 11 (14.12.7) it ii i6 iiio.io.n it 11 ii 11 1) 1f 11 ii ii ii ii ii ti 11 11 ii ii |1 1 17 125.11.74 ii ii 1I \1 I| ii it ii ti ii ii ii ii ii ii ii f 12 J IUSTOLOOTCAI. ( CONFIRMATION |Yea (N10SIO {Tee (NI0SII> |Yea (NIOSH) ITl-a (NIOSH) ti 13 | 14 | 11 1 ESTIMATED | | |EXPOSURE OCCUPATION LEVEL || 1J ii ii i|PolpworRer i| 11 OTHER CAREER HIGHLIGHTS 1 (Potyworker i i inning 1 ] i i i (pesticide | laerosnt cana( |wtHi VC | ii ii ii ii ii ii ii ii ii ii ii ii tt ii I1 200-500 ppa|Pn(yworkar 1||95S vai hut hfj(h | temporary (antocleaner during 1 yr |eutocteaner (for l yr antoclcanerf | ii ii it ii ii ii ii ii ii ii ii ii ii i 1 16 1. . | OTHER | COMMENTS 1 i l 1 1 1 I ( i i i| (Reported under |non polyaer- (I nation (workers In JNIOSH Hat of 131.3.77. IThta of cowrie 11 a strictly (correct. (However I (wonder Ivhether this (an had high lexpoaure to (VCH In hla (can fit Mag (operation! 11 |Cllntcal (details In |paper by (Ookel et a] |Vlrchowa Arch 1A Pnth 1976 1)71 . I95-1D3 1 1 1 1 1 GENC 008755 IHPEKIAf. GIIKHJCAh INDUSTRIES MjC. PKTROCItfiJlf CA1.S AND Pl.ASTICS DIVISION LIVER Anftlnearcoma Canea - (Review Hate: 15 April 1983) Germany Sheet 2 Page 9 t 11 l 1 mt AND | ERENCE ( HO 1 1 1ANY 1 t 05 1 i SII glvea| ^aae 06) ( i i i i i i i 1 1 ( i i i t i l 06 1 1 f)SII gfveal Case 05) t 1 1 07 1 i i i i i t i i 1 * i CIS | 1 1 1 1 2 NAME OR INITIALS lt | DATE Of | | fURTII | COMPANY ii ii ii ii 11 IDO.00.36 | Hoechat ii ii it i( it ii ii ii ii ii 11 ii i> ii ii ii ii t\ |00.00.12 | T.onea ii ii ii ii ii inn.nn.36 t Wicker 11 11 11 11 1I 11 11 11 11 11 11 lDII.fin.171 llyitanlt 11 11 11 1 L. _ -* 1 |5 1 1 1 | FACTORY 1 1 1 1 6 FIRST VC EXPOSURE 1 Frankfurt 02 .04 *60 1 i i t 1 1 i i i 1 i 1 t i i i i i 1 |Wald shut 16.12.62 i i i i i 1 Burg- (haiinen L5.D4.54 i i i i i i I i i it |Trnl.<!i>rf 1 19.(17.54 11 11 11 _1_ L 11 | 7| 11 11 | DATE OF | | DIAGNOSIS 1 ii ii ii ti | 10.12.71 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 !l 1 v- ' 1 1 00.no.75 1 1 1 1 1 | 12.11.75 1 1 1 1 1 1 1 1 1 1 1 j D6.04.M 1 1 1 | 1 1 1 1 1 1 | 1 1 | 1 1 1 1 1 | 1 1 1 1 1 1 1 1 t | 1 1 1 1 1 1 1 1 1 1 1 | 1 1 1 1 81 9 AGE AT DIAGNOSIS years nr EXPOSURE TO DIAGNOSIS 1 1 1 IS 1 13 1 1 1 1 1 1 1 1 1 1 1 ! I 43 1 I I t 1 ( 49 t 1 t 1 I 1 I l ( 1 1 5R 1 l 1 I -L n 21 21 i 1 10 1 1 | YEARS OF | EXPOSURE 1 1 1 1 1 "5 i i 1 1 t 1 1 i i i r i i i i i i i 1 12 t i i t I | 21 lOmtsn | nays 12) 1 1 i i i i i i 1 1 22 1 1 1 1 i 1 II i 1 13 11 1 1 n 1 14 1 15 _L 1 1 ii l1 | DATE OF | IITSTOLOGTCAL I ESTIMATED 1 1 1 OTHER | DEATH 1 CONFIRMATION I EXPOSURE | OCCUPATION | CAREER ii f MV El, i i HIGHLIGHTS i i.............................. .. I JL ii ti i ii Ii i 116.12.74 |Yea (NlflSU) ii ii ii it ii ii ii ii ii ii ii ii ii ti ii ii ii ii 1\ 109.01.75 | Yea ii ti ii ii ii 111.11.75 | Yea 11 11 11 11 11 11 11 11 11 11 11 135.13.75 1 * 11 11 11 11 t 1 I I I I I I I i 1 I 1 1 l l 1 l t 1 1 l 1 I l l I 1 I I I 1 I I ! 1 1 l 1 l l (HO Chemle I laaya 1 1 "cheatatry 1 | EahnratorJ anl Jin the I (Techno- | 11oglcal I Ifteaearch J (Department* 1 |(HIOSII .ay. | (aaalatant | (factory 1 Ichemlat I (which nay he| 1wrong | | trsnalat Jnn)| ii it ii 11 (PVG - Hanu- 1 (factors | (Shift header) ii ii 1 |PVC Mann- I I (factors and ( fall work ( Jlncl auto- | (cleaning ( 112 y r. 1(1954-60 1 | |Forenan Tech| |Pev 8 yra | 1(1967-1975) 1 J. L. 11 7 Jpolywnrk.r t 11 11 11 7 1 t (6 f 1 | OTHER | COMMENTS t ( 1 |Can firmed ( | i 1 | | 1 1 1 | |Reported imder| (non-polymer- I | teat Inn | IworVera Jn | IN10SH Hat of | |31.1.77 and | (1.78. 1 don* 11 IthlnV tlila la | (a correct 1 (c leastftcatlonj (fay NlOStt. The| |nan may have | |heen Involved | Itn VCH | 1 polymer I ration) 11 n pilot plant| |nr tn main { (plant. 1 ii ii ii 11 ii ii ii ii ti ii ii ii 11 ii ii ii ii ii _i_ i i i i i i . i i t i i i i GENC 008756 IMPERIAL CHEMICAL INDUSTRIES PLC PKTROCIIF.H ICALS AMD PLASTICS DIVISION I,IVK.R Angiosarcoma Caa^a - (Review Date: 11 April 1983) Germany SheetX Page 10 1 11 l |2 13 1 4 11 1 1i COUNTRY AMO | MAMS OR | DATE OF i REFERENCE | INITIALS | BIRTH | COMPANY HO [ pi 1 tp GERMANY I | pi pi 09 | 1 ton.rm.34 1 am i ii i ii i ii i ii i lI 1 iI i ii i it i ii 1 10 l 1I 100.00.36 1 own (NIDSI1 gives | as Case 11)1 ip 1i i ii i ti 1 I ti 1 I ii 1 1 pp 1 1 ii II 1 ItCHIOS gl vci | as Case 10)1 11 |00,00.29 | Hacker 1i 1I i 1i t 1t i 1i !i '1 l 12 L ii 1i (011.00.38 | Hynsmlt fI i i ii i i pi i ti p ii t ii i ti t ii t ii i ii i ti p ii i ii 1 |5 1 i i | FACTORY 1 1 l 1 |i p 1 it 6i 7 n1 9 i in 1 11 iP 1 i r1 p1 FIRST VC i DATE OF | ACE AT 1 YEARS OK i YEARS OF I DATE OK EXPOSURE p DIAGNOSIS 1 DIAGNOSIS | EXPOSURE TO i EXPOSURE J DEATH t i | DIAGNOSIS i i i p1 _L i i1 li t iI li IKarl 20.02.61 ! 16.116.76 | 41 1 19 i ii t 1i! i Pi1 1 i1 1 1i1 i 1i1 i 1tP i p 1 JMarl !t1 1 1 01.01.61 oil.ni.77 | 40 1 16 i 11 i 11 i 1i i 1i p 1i ii !i 1 i i 1i i (Burn- i11 10.10*55 i 28.n6.77 | 47 1 22 Ihsnaen i ti i ii1 i iit i iii i ii t ii 1I i t I (Troladorf ( 00.00,61 i nn.in.77 i 39 1 16 I 11 i iii t pii i iii i iii i iii t iii i iii t iii i ttt i ii i pti i n 124.03.78 1i 1i li i Pp li li 1i 1i 1 1 10 107.03.77 li ll li !i Pt 1i tp 1i 221 1 1 128.06.77 1i 1( 1i 1i 1i 1t 1f P 6 J07.JH.77 11 1i 1i 1i Pi ti 1i 1i ti 1i 1i 1i 1 ii 12 in i i* 11 HISTOLOGICAL t ESTIMATED l CONFIRMATION | EXPOSURE | OCCUPATION J LEVEL | ] it ii 13 OTHER CAREER II mil I.TCMTS I 1 r i | | t 1 1 1 16 OTHER COMMENTS Yea Yea Yea Yes llligh peak* I | 1 ] t. |I2 yra poly-1 Iworker lncl |17X autoJclfive Icleanlng [Control roon] 1 1 1 1 llligh 1 \ | 1 peaks |1 yr 1 1 -J 11 |LO yra poly-( (worker lncl |I7X auto** Iclave |cleanlng i i i i 1 | High I | i i i i 1 Jl yra auto(clave (cleaner 1 1 H rr. J (fl)ter | (operator ii ri 1 7 (PVC Kami( (factiire | (Autoclave | (worker for 1 1* rr* 11 11 11 11 1t t1 11 11 -1_ 110/7* 1 Confirmed |Average (exposure first |9 yre ISO ppm, focc 1000 ppm. |N*t 3 yra av, |75 ppm. Leaf. fjrr av 35 ppm j 1 | Average (exposure first (9 yra 150 ppm, |occ 1000 ppm. |l.ast yr av |75 ppm* Cwil (letter of 121,04.78 1 i i 1 1 i i i _j 1 1 1 i i i i i i t i i i i _i GENC 008757 IMPERIAL CIIKK1CAL INDUSTRIE* M.C PETROCHEMICALS AND PLASTICS DIVISION Germany Sheet 4 fan* 11 LIVER Angiosarcoma Caties - (Review Date: 13 April mi) iI fTRY ANl> ERENCK NO NAME OR INITIALS 3 DATE OF BIRTH 1ANY 4 COMPANY (5| 6 11 i i FIRST VC | FACTORY | EXPOSURE ti ii 7 DATE OF DIAGNOSIS R 1 9 1 10 i n 1 12 1 13 1 14 i 11 1 ACE AT | YEARS OF | YEARS OF | DATE OF | IIISTOI<OC1CAL 1 ESTIMATED i DIACNOS1S | EXPOSURE TO | EXPOSURE | DEATH J CONFIRMATION I EXPOSURE | OCCUPATION i | DIAGNOSIS | i i LEVEL i i ii i 15 OTHER CAREER HIGHLIGHTS 1 1 1 1 1 1 16 OTHER COMMENTS 1 | | 1 ( n u 13 SII gtvcs| i as ! 13) 16 OO.OO.I4 no.00,29 no.no,23 Lanza WacVer DynamJ t | Wj3 1<J altn t | 00,00.60 OR.04.78 ii 11 ii 11 ii ii ii ii ii ii it ii ii ii ii ii ii ii tI ii ii ii ii ii ,,- r" ti (fturghaueen 19.10.53 09.10.7ft ii ii ii ii ii ii ii ii |TroJadorf| 10.01,35 07.0fl.7H ii it ii i[ ii (La 1hack swapocted AS1. at FeL 1975 laparotomy) 11 ii ii ii ii ii ii ii ii ii i 63 | i i i 1 i ! 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 49 | 1 1 1 1 1 I 1 t 55 | t i i i 1 1 i t i i i t i t j Ifl 25 21 | 14 J19.05.7fl 1 Yea | i i ii i i ii i ii 1 ii i ii i i i i 1 ii 1 [Nat an | 1 |Angiosarcoma ( 1 |In hla letter J 1 lof 21 12 61, | 1 |Mr Frleilel | 1 laatri this wia J 1 |a "PIattenepl-| 1 1 tlielkart Inom J 1 lOer | 1 JSpetaerohre" | 1 |(a carcinoma | 1 |of the J 1 loeeophagua) | 1 |not attrlbut- J 1 lable to VCM t t 1 loot recagnlaedl 1 |aa an Indnet- t 1 trial dlaenae | 1 i i i i i i i i i i i i i i t i r i 1i | 15 |23.J0.7fl 1 Yea i | |Autnclave t i t i i (cleaner and i 1 i t I worker. i 1 t i (Drier i 1 i i [operator. i 1 i i (Later shift t 1 i t J leader i t ii i 1i | 20 I07.08.7A 1 Yea tt J IliKh |AutnclAve i i |ASL and | |worker till i t ptejiatocel lalarl 11964. i i |Carcinoma | |Leader and i t i i Imaater p 1 ii i l it t i ii i t ii i i ii i i ii i i ii i i ii i i ii i ii i LI i ___ i i GEN'j 003758 IF W Seat J lletter of | |3flt1i June 1900| |enclosing data| | f roa | (Mr H P Frledel| lof RC Chemle 1 |f W Rest | (letter of | 130th June |4Sri| Jencloslng data] 1fron | JII P Frledet of | |RC ChemJe l (withdrawing | Ithla case | t| iI ii i| i| i| 1I 11 i i | Angina a rcnata 1 | (confirmed ) |09/29. Sdm 1 (detail of this| |fc also cases | i. n, is, is j 16 i7 glven in J |NRW Report for| M92S 1 (Angiosarcoma | (confirmed, J (full details J (of Illness ( (alnce March 1 11973 gIvcn In J |NRW Med I nap f (Frp far J97fl, | (Different 1 (details glyen | rin "VC | {Associated J IDIeeaae" by J ILelhach and | (Harataller J 1(1961) p? 1, | - i \ | ; j 'j IMPERIAL nilCM ICA1. INIMSTMKS N.C PETROCHEMICALS AND PLASTICS l>]V(S[OH 1?e rmnoy Sheet 5 rati* 12 LIVER Aii^l nnarroma Canes - (Review Mate! 1^ April IRfll) 1 l1 1 1 OIJNTRY AND J reference NO i ] t EHHANY 1 | 1 21 1 1 NAME OR | INITIALS ) 1 1 1 1 21 DATE OF RIRTII J l' COMPANY ill i I 11 1i i 1 5 1 ft 1 7 1 1 9 1 10 1 II 1 12 It 1 16 1 15 1 16 11 -L __ J- J_ _ 1 1\ I1 | | FIRST VC DATE OF l ACS AT \ YEARS OF J YEARS OF \ DATE OF l HISTOLOGICAL | ESTIMATED I | OTHER l OTHER | FACTORY | EXPOSURE 01ACN0SIS | DIAGNOSIS | EXPOSURE TO | EXPOSURE | DEATH | CONFIRMATION J EXPOSURE | OCCUPATION | CAREER | COMMENTS iii i | DIAGNOSIS 1 1 LEVEL i I highlights j iii i 1 11 _L_ 1 iii i 1 11 1i 1 iii i 1 11 1i 1 17 | NlOSII gives) a Cnee IS) | | I 1 1 I | i 1 i i t i i 1 i i i 18 I 1 1 19 | 1 1 i i 14 l 1 1 1 1 ----- --- fl | 1 1 ) 1 1 12 | 1 | tOO.00.37 | Dynanlt i i l i i 1 1 1 i t i i i 1 i t i i i too.on.n l lloechst i i (OO.flO.25 | Dynamic i i i lOo.nn.TT 1 1 i i i Pynsmlt .1 'ioOo.1T | Dynanlt ) t l l 1i iM.firt.2l | Dynnnlt 1 l .!________ (Trolsdorf| OI.U.M LA.0R.7R iii iii iii iii iii iii iii iii iii iii iii iii iii iii iii iii iii | t i i i i i i i i i i i i i i i i A) i i ^-i i Ifiendnrf 1 rtn.flrt.55 | 25.12.14 | III III |Troidorf| 18,10.56 | 00.08.79 1 1 | III III III 1 1 1 fIII 1 (Troladorfl U.02.61 \ 0U.n4.fln iii iii iii iii i i i i -iTrtYdn7ff (fOnTST }' fio.M.T?"J 66 54 AS 66"" I| 1I 11 || (pronounced IcIInical I liver layninnn) | | | | iii i ITrnledorf| t4.10.4l | if-OO-flfl | 59 II! 1 iii i _J._____ L _1J.................................. 1 i i i i i i i i i i i i i i i i i i i 1 i i 1 i i 1 1 1 i i i | I ( 1 I 1.. 1 l IS 24 25 19 j; 1 11 i 1 i i i i i 1 i i i i i i i i i l2fl.OR.7fl 1 i i i 1 i 1 i i 1 i i i i i i i i | Yes i i 2 L 121.12.79 | i Yes ii i in 122.02.an l Yes i l (Hetaatsal ng i t IASI. i ii i IT" lT?.in.fln | Yea i i lllncmangl n I I (Endue he 1Iona i i |nf l|ver with i i IHetaatanes ..... "T)~ "m.MT.M 1 Yea | i 1 (llaenangto i 1 | Kml ui he 1 Irma i 1 |of 11ver with i 1 |M*taatft*ea L ,,!____ | l "TT* in6.TT.sl | ten 1 7 (Hetaataslng J 1 1 |AS1. _L. III Rl. HI fit' ninii mull HI KH |Autoclave | Nn |Anglosarcona Worker i |conflrned. ii ii ii ii (Annual report |of the North |Rhine Westphalia i i i i i i i i i i i i i i |Autncleve (Worker _! | Antod eve |WorVer i i i i i i i i i i i i i i i i i i i i i IHedlcnl | Inspectorate 1 for 1916 (pages 347-277 (gives foil Idetalla. Vinyl (chloride (disease (diagnosed 102-02-73. (Oesophageal | varices. (probably aero (osteolysis. t 1 _j__ (Or Resche |letter of 113-04-A2 to |Df W G F Allans j t Aii tod avc Worker i i i i i i --L |nr Reache lletter of 11 3-04-A2 to |Dr V C F Adans ii i i f Autnc.leve t ]Worker and i Worked In i Idrylrig shop i i |Pr Resche lletter of |U-n4-82 to ir>r w C F Adane ii t |Autod nvn iChnrRelmn.J, i (Dr Resells (Worker (fliihseiptent i y (letter of i IForenen (13-04-H1 to I1 |Dr W C T AtJaiis GENC 00875? IMPERIAL CHEMICAL INDUSTRIES PLC PETROCHEMICALS AND PLANTICS DIVISION LIVER AnglOHarcnmn Cnacs - {Kevftw Date: 15 April 19H3) * Should tills cnoe he removed from the ItstT HI OSH have it on their supplementary lint relating to nnn-poTyiner illation workers exposed to Vf>1. >*ft n i 1 12 3 11 1 I K If AND | NAME OR DATE OF HRKNCE 1 INITIALS MKTII HO 1 I Ti i 01 11,0 5*06.34 Hinsu >rle- 1 1 it ary 1 it) 1 1 1 1t 1 02 | S K 1*11*29 i i 1 03 tve 4*03.20 1 1 1 1 l 1 04 tFfl 20.07*17 i i i J i 1 t i i 1 1 i 1 __L i1 4 i5 16 COMPANT 1 11 1 | FIRST VC | FACTOKI | EXPOSURE 11 11 1i PAHSAC 1 1 1 i l oo.on,65 l )1 1l 1l 1l !l 11 11 Honied 1aonlPnrto | (Ml.0(1.5) IHargliera | Sulvay 1 1 (Ferrara 1 I no.ni.si ii ii ii t( AHIC i 1 |Ravenna 1 1 | 00.04.59 ii it 11 li ti i1 1i (i ii ii 11 11 11 1i .1 _!_____ . 1 7J h 1 '1 DATE OF | AGE AT DIAGNOSIS t DIAGNOSIS 1 9 YEARS UK EXPOSURE TO DIAGNOSIS 10 1 11 HEARS OP | DATE OK EXPOSURE | DEATH 19.04.71 11.12,72 i i | 1 1 1 1 l 1 1 1 | i 10.07.75 1 | i i 1 36 * 43 55 06 15 22 03 tU.D4.71 06 117.12.72 J 21 (10.07.75 nn.oi.Rt 1 1 i i i i i i t i t i i 1 1 1 I 43 __________ . 21 t___________ 21 I30.03.AI .L .IS l/fl/77 "r............. 12 i n 1 14 15 1 16 | 1 ..... 1 HISTOLOGICAL | ESTIMATED CONFIRMATION | EXPOSURE | OCCUPATION I LEVEL OTHER CAREER HIGHLIGHTS | J OTHER CnuHENTS | \ Uen Yes Yes Yea 1 t i* | |fvc Kn* * i IPrlwary tuwuurt 1 lextfuder 1 1 1( 11 1t |*ay have been Ipericanilnm. |Hnt homoIgenenus with lother cases. ]* *4* | 1 | | | | 1( 11 | Ifolyworker 1i I ** 1 1 *** J 1 1 | High i 1 | Autoclcnner 1972-5 cl Id i |B yr. (1953- s variety off I i 161) Autorlav Jobs 1 *** 1 i loperetor lnctudlng 1 112 yr. <1961 PVC packing J") .1 I 1 | 12 yrs * H yr - 1 Very lllflh IMonomer 1 loperstor 1 5 r - i | Medium |20 rr. - Never cleaned sutoctaves. See paper hy CHIAPPTN0 et al Ked Lavnro 1 *** |Non-awoker. JConsumed | | | i 1 9 yrt J l.ow lAntoclave Vol 4 (1942) |opertnr 6 pp 555-563 lother duties llittla | |alcohol. Ho | |AOL. | 1 Jin nuapens1 lion polymer** ( 11AAtlnn. 1 I (Area Foreman 1 11 it same Dept 1 Isince 1975, I Sea Hiltout Ned ill l.Avnru 65 p445, 1974, Further details In tetter from Hr Hmiloamin of IARC un April Ini I9RII. Also see Haltool end Rond fuel la In Acts Oncologies Vol 1 19S0 pages 35 - 49. (ICI lias made a trunelaClon of this paper Into English nod copies of the trAusIstlon can he made svsJlshle oil rei|neat). GENC 008760 IMPERIAL CHEMICAL (MI)M.STKIKS PLC VRTfltHMF.Hir.Ai.ii AND PLASTICS DIVISION LIVER AiijjlrtHnrcom* Case* - (Review fiatet 15 April 19B3) P-K* M l OUMTKf AND REFERENCE NO APAN 01 02 i1 2 |3| 4 l5 tt l NAME OK | DATE OF INITIALS 1 BIRTH | COMPANY t i I vAcnm* 1l 11 1l il |i TonoJ1 Korl 101.08.22 \ J i i I IMLtB.il INsjjoya IToatau 1 f(no comment( 1 hr .tan PVC I 1Aaaoc) 1 1 11 lt l| i1 11 11 1 SO 102.08.59 1 1 1 t l1 l1 i1 i1 ----------1 4j 1 1 716 9 JL. ... 1t FIRST VC | DATE OF | AOF. AT YEARS OF EXPOSURE | nr acnosis | DIAGNOSIS EXPOSURE TO 11 11 DIAGNOSIS .... li fi | *1 no.04.51 1 24,10.75 1 * 55 * 22 1 1i li 1i 1i 1i 1. 11 1i on.n.sr 1 1 1 i in.oa.7A i i___ ____ l 1 3? 17 it Ii ii ^i i i 1 io | YEARS OF | EXPOSURE in in 1 i1 1 t 1 12 1 13 1 14 J______ ... i J______ _____ l i 1i DATE OF 1 msTninctcAL l ESTIMATED t OEATII | CONFIRMATION ( EXPOSURE | OCCUPATION 1 | LF.VF.L 1 .L _i______________ 1 l i1 1 t1 1 |2li.l0.75 | Yea i1 JPVC Aaaoc 115 yra auto- i |naye not (clave i |known. (cleaner i ]* Japan 11964 - i |Tlmea leeetgned to i |1nd1cated (different i |on 25*tO.75fwork elnce t Jexpoauree (had Ml i (often at (health 1 15000 pp upl i l to 1974 i i 1 I0.08.7A l i i i t Yea J____________ 1 INot known | | 1 i _L 1 |In polymer| Eaatloa work |lncludlng (autoclave (cleaning 1 15 OTHER CAREER HIGHLIGHTS i i j. l | OTHER | COHMENTS 1 J i i i (Japan Tlmea (25.10.75 4 (Japanese PVC (Aaaoc letter |of 11.03.78 1 1 1 1 t 1 J__________ 1 (Japaneae PVC (Aaaoclatton lletter of 111.03.78 I 1 1 In Me letter of iat April 1982, Dr Monteaauo of I ARC aaye J apaneae Ministry of Labour give Date of dlagnoela Ape of dfaftnoala Yeats of oxpoente 21-08-74 52 22 GENC 008761 IMPERIAL CHEMICAL f N1XISTR f KS PLG RTROOieHlCALS AND PLASTICS DIVISION UVKK Angiosarcoma Caeca " (Review Dato: 15 April PaK 15 1 l1 11 l 1 2 { 3 * 4 J5 1 & 1 1i 1i l 11 JNTRY AND 1 NAME DR | DATE OP 1 IKfiSENUE 1 INITIALS 1 BIKTH I COMPANY 11 \ | FIRST VC | FACTORY | EXPOSURE NO t 1 11 l t1 i1 OMT 1 | ii ti ii it 1 01 | AH 1 |21.12.15 Norsk i IHoroye 00.OS.50 |\ \1 Hydro 1 | | i 1 | \l || l) l| [1 l| || || || | || |t 1 11 tl | 1| l| 11 i ii ii !i i ,j____ j 1 1 1.................. 1 18 9 1 in J M 1 12 1 | -L j 1 1 11 IIATK OF | ACE AT YEARS OK | years of | DATR OK J HISTOLOGICAL DIAGNOSIS | DIAGNOSIS EXPOSURE TO | EXPOSURE | DEATH | CONFIRMATION i DIAGNOSIS 1 ii i 1 _L i I l1 i 1 II 21 .12.71 1 i i i l I I I 1 I 1 l t i i 56 22 1 21 |04.01.72 t Ye* i ii i ii I Ii \ ii 1 1i 1 1i t 1i i ii 1 1i 1 1i t 1i l 11 1 li i ii _ i______ x_ -" 1i 1 u 1 1* i 15 1 16 1i i 1t ESTIMATED 1 t EXPOSURE t OCCUPATION i LEVEL 1 i OTttP.R CAREER HIGHLIGHTS 1 | | i OTHER COMMENTS .1 . .j 1i i 1i i i i iuh |Foreman 4 \ Autoclave 1 super*tsor i i i i t i i i 1 i i i i i t i i i i t t i i i i i i |Confirmed by (Hr Thlie(EvAnaen of Nil. |At APHR MCK nf |9 Jim* 197ft |Mr P RaoRiiea fjitated that All |hsd been a |*enl>er of s |atart~up tea** |VCM 4 PVC were |narfe In tunc Ihulldlng. The IVCH wee ade ffro* acetylene ji 1 ___ L___________L .... GEMC 008762 IMPERIAL CHEMICAL iNDtISTK IKS 1*1,0 PETROCHEMICALS AND PLASTICS DIVISION LIVER AnRlnniirciina Canns - (Review Date: 15 April 1983) PaRe 16 in 12 13 14 15 16 OIIKTRY AND REKERENCE NO HAKE OR INITIALS DATE OP BIRTH COMPANY PlRST VC EXPOSURE DATE OK DIAGNOSIS WE DEN 01 23.06.27 Kcnanord Sundeval1 14.OB.51 20.10.70 27.1 l.l l Keaanorrt Snndaval1 00.01.43 on.Oft.72 03 10.06.10 Xeaanord Snndaval1 00.05.47 18.03,76 16.II.14 Xemanord Snndavall 00.00,46 12,05,77 _ 05 12.03.19 Ktsn&nnrd Sumlaval 11.05.64 22,1 I .#10 ACE AT DIAGNOSIS 43 62 YEARS OP EXPOSURE TO DIAGNOSIS 27 29 31 16 YEARS OP EXPOSURE HATE OP DEATH lltSTOLOG TCAL OONPIRHATION 1 P.ST [MATED 1 EXPOSURE | OCCUPATION LEVEL 1 ______________ 1_______________ OTHER CAREER HIGHLIGHTS OTHER COMMENTS f I I 20,10.70 27 16.OE.72 Yea IPolyvorker ..J______________ High |VCH [product Ion _L I )Mr S)oellrv'a I letter of 128 March 1976 (conflrna RL |waa a sononer Iworker who was (heavily lettpnaed, (probably even |nre ao titan la normal Ireactor | cleaner l ____ 21 19,03.76 31 12.05.77 Yes Yea High JPolyworker ____________ i______________ in cii 111*6-19511 Ipoljner* I la.tton Iworker (12 ift.) i ma11972 fore.fln 1(19 *r.) I I I___ 16 22.1 I .HO .L......... i mull - im*-i97n 6 Years {centrlfiige Low - |nperator 10 Yesra |I970-19B0 |Hrler |operator ________J.________ I |Tn Mrat 12 lyre of leaploynent hail lbeen heavlly leipoeed. In 11974, liver | ahnora* 11 tjr land necrnsla ]dlaRnoaed. (Data conflr*e< Jin Hr D Byren {letter 18.B.7 |to CEPIC _L________________ I ILnttcr of | 2nd Nrv 1 98 I I fro* |Pr David Ryre I * In hJa letter of Lnt April 1962, Dr Hnnleanno of IARC aaya In Smut*' of OS Health tflvca 20-02-70 as drite nf .llnjtnnalfl for Caao 01 and 15-05-72 fnr Caan 02, GEMC 008763 HJNTRlf AND EEEKENCE NO NAME OR INITIALS DATS or BIRTH IMPERIAL CHEMICAL INDUSTRIES Pl.fi PKTROOHEMICAI.S AND PI.ASTfCS DIVISION LIVER An^lo^nrcnma Cases - (Review Date: 1% April 1983) me Sheet I P*Re 17 FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS _____ ACE AT DTACNOSIS YEARS OF EXPOSURE TO 01ACNOS IS 10 YEARS OF EXPOSURE OATE OF DEATH 12 If ISTOLOfrtCAL CONFIRMATION 13 ESTIMATED EXPOSURE LEVEL OCCUPATION 15 OTHER CAREER HTCIILICIITS OTHER COMMENTS 20.04.01 Ifil Hllihous 04.04.44 01.12.72 ( Fox A Collier paper soya 23.12.72) 71 L_______ 22 03.12,72 (Fox A Calller paper eaya 23,12.72) 03 02.06.37 04 JSft 23.06.20 Barry 00.02.66 00.12.74 37 III l Lhouse 26.04.54 00.06.79 59 1.5 24.12.74 25 12.10,79 500 1944-7 VCM 1947-8 Orler 1948-61 Autoctave operator 1961-66 Drier Lee and Harry Lancet 29-06074 pa^es 1316-8 Dubious fahrteatIon case High Autoclave cleaner Exposure l Imlted to 2.66 - 9.69 Hedl<mI'tgh 54-5 Bangle* Plant 55-6 Drier Plant 56-58 Autoclave worker 58-61 Che rgeliaiwt Drier Plant 61-72 Foronen C 2/1 Plant Pre-war flah jiecker 939-45 army vehicle Maintenance 1945-54 flah packer SENG 003764 1 1JNTRY AND KFKRENCE NO 05 NAME OR INITIALS DATE OR BIRTH 30.01,1 A CEP 1931 BP 07 RCB 26,04,20 oa oa.os.2f IMPERIAL CHEMICAL INDUSTRIES Pl.C PKTKOCIIKHl CA?*S ANN PLASTICS DIVISION UK Sheet 2 Peg* ,IVKR AnRlriaurermia Caeca - (Review Date: 15 April 1983) 15 1 | FACTORY i 1 | Parry | 1 t ( i i i | | i i I Barry i I I i i IBarrjr 1 | 1 1 |Barry 1 1 1 | | 1 \ i i ( | ( \ | | 14 i ---------J 1i | FIRST VC i DATE OF | EXPOSURE t DIAGNOSIS iL 1I | OB,01.51 I 00,10,79 11 i1 11 1 iI 1 il iI iI i iI 1 1I tI 1! 1 mi 09.01.an i iI t il i| | i 963 l 00.00.BO 1I 1 iI iI ii | 19,09,50 t 27.lt.Bt l i| tl il II I| If 1 it || il [| || | 11 || i| 11 11 il il iB l | AGE AT 1 DIAGNOSIS i 1 | 65 1 1 i l i i i i i i t i i i i i 4*79 i i i i i | 60 1 1 1 1 | 57 I i i i I I I i i | 1 I I 1 r i i i i i i 1 9 1 10 til 1 1 .1 1 | YEARS OF | YEARS OF 1 DATE OF | | EXPOSURE TO | EXPOSURE | DEATH 1 | DIAGNOSIS i i 1 11 | 28 | 21 119.11.79 i ii i i: t ii 1 ii i ii 1 ii 1 ii i i) i ii i tl i ii i ii i ii i ii i 1 If? 1! 1 12 109.01.BO t ii 1 11 1 11 i ii i 1 17 ii | B2 (13.04.BO 1 11 1 11 t 1i 1 11 1 1 31 | 24 125.12.BI 1 11 t 11 i 11 i 11 t 11 J 11 1 11 j 11 i 11 1 11 i 11 i 11 1 11 1 11 i 11 1 11 i 11 i 11 1 || i 11 i 11 12 i n l H 1 15 1 1I HISTOLOGICAL | ESTIHATED | OTHER | CONFIRMATION t EXPOSURE | OCCUPATION | CAREER | | LEVEL i i i i t 1 i t i i t i 1 i i L_ t 1 1 1 1 1 l I I I i.................. - 1 HIGHLIGHTS 1i 11951-52 i | Pol yet ee iter i 11952-55 i |Latex i 11955-60 i IPolyfloor i 11960-64 i IBoljr i (Charflehand i 11964-70 i lOli.ruin* t |operator t 11970-72 i IDrler i (operator i -L_____________ J______ 1 7 jrt i |Poly Floor i |Operator i 15 yri 1 JCreaaer on i (Poly Floor _L_ |Polycleaner l 11961-5 1 |Recovery I (1965-197! 1 I '1 I l i ...___________ 11950-ma 11950-51 (T93B-I94B |500 pp* lAntnclava |1966-1974 loperator IHotor Kechanicl 11948-1950 )200 pprt i t i i i i i i i i i i i i i i i i 11951-1957 lOperatnr on | Charge atan | Acetylene | autoclave (Production |but ldlitR (Plant 11957-1974 |Shift i i lattperv leor i (autoclave i (hullHIax " i |Never i (cleaned i Jautnclavpa f Jhut i lauporvtaor' | |Joh enta1 led| lentcrtnR i lautoclavea i |to inapcct i | thUR 16 OTHER COMMENTS GENC 008765 l 23 JKTRY AND TERENCE NO NAME ON INITIALS DATE OF HlRTII 09 Eltt? 07.05.25 4 l5 COMPANY | FACTORY RP |Barry IMPERIAL CHEMICAL I MOIISTftl KS PLC PETRI (CHEMICALS AND PLASTICS 11IV [SION UK Sheet 3 LIVER Angiosarcoma fatten - (Review Cate? IS A|>rX 1 I9S3) s FIRST VC EXPOSURE 15.02.50 7 DATE (IF DIAGNOSIS 02 .01.A3 fl ACE AT DIAGNOSES 5FI 9 YEARS OF EXPOSURE TO DIAGNOSIS 33 10 | n 2 | 13 1 14 1 13 \1 1 YEARS OF 1 DATE OF i HISTOLOGICAL | ESTIMATEO i | EXPOSURE t DEATH i CONFIRMATION \ EXPOSURE I OCCUPATION | OTHER CAREER i i LEVEL i | HIGHLIGHTS 1 29 124*02*83 Yea 1 | Medium 1t |Pot yvorVer |2 year* on 1 | J ii ii I Aerylnnltr1le Realn Plant* I Alao far lor to $ 1950. 4 yeara| RAP | maintenance. | 3 yenra motor | cor palntahop.| 1 yeata la | Graving DocV, ) Pa*e ]9 tA OTHER COHHENTS ....I___ GEMC 003766 IMP RATAL CItRHIfZAt, INDUSTRIES |'LC PKTROCHRM(CALS ANH PLASTICS ft VTSlftH LIVER AnKlosafconn Cqeee - (Review Date 15 April I9H1) UK ayeten of riatea hay - month - year (IS A Sheet L Page 2ft 1 |2 11 ill 4 1 11 1 l1 OUNTRY AMD | HAKE OR l DATE OP | REFERENCE 1 INITIALS | BIRTH | NO t ii i ii COMPANY SA OJ i i i | Car L 1 Parka ii ii ii |H.10.21 | CFO \| i ii i ii i ii i ii i 1 02 | ii 11 M9.Oa.13 1 RFC i ii i ii i ii i i< 111 01 |toward I21.01M5 | RFC IDInwIildJe | | 1 11 1 1 04 | !1 11 (15.01.24 [ BFC i ii i 05 | ii (25.01.12 | RFC 1 1 J 06 (Ray 11 ! . .1 11 (23.II.2a | RFC lAuattn |Junea1 t \ 1 | t ii i ii ! 11 I 11 o; |CLarlee 101.05.22 | (ICC (T Samrc | | L 1 oa | LI 11 (06.05.20 | Goodyear t1I 1 11 1 1I 1 |5 1 6|7 t i i | FACTORY t 1 FIRST VC | DATE OF EXPOSURE | DIAGNOSIS ii i i i i ! i.o*> la ~ i i i i 09.t2.4B | 03.01.73 | villa t ii ii tt 1i 1 1 | IrOlllS- i 1 (5.11*55 | no.05.70 1 vl lie 1 1 1 i1 i 1 |l.ot(la~ 1 vide 1 1 28.11.45 t 19.12,n t 11 1 1 |Lou la- l 06.07.52 l 19.08.67 I v l lie 1 1 1 (Louie- 1 1 19*06,44 1 09.04.64 | vllle i 1 1 | Iwvula- | vl He t 1 i i 1 17.01.62 | 00.02.74 i i 1 i ii i _L . 11 |S Cliarle- 27.OR,44 1 00,00.6ft ( aton i ______ L -L____ _____ i 1HLagnra 1 07.10,46 1 oo.nn.6i 11 11 11 1_ .L _____ i 1 11 ! ti ai 9 1 10 l 11 1 12 |n i 14 1 15 1 16 1 i i t 1 .t ! 11 1 l |1 11 AGE AT 1 YEARS OF 1 YEARS OF | DATS OP | HISTOLOGICAL | ESTlHATEn ( ( DIAGNOSIS t EXPOSURE TO ( EXPOSURE | DEATH | CONFIRMATION I EXPOSURE 1 OCCUPATION 1 OTHER CAREER 11 | OTHER | | COMMENT S | i OrACNOftlS t ii i LEVEL I ( HIGHLIGHTS t i i i ,L_ __L !1 1! i i t 49 1 24 i ll i II i II 1 21 101.01.73 | Yea 1 1 i | i i 1 IPot Cleaner IIII aCory Riven |In Anna la NY |ACAD SCIENCES 1 |Rol1Iar Stone 1 Art |Ref 1 NY Acad 1 i i ii i it t |(Block Jab* (Vol 229 C(979)(of Sc Sy.p i t 1974) p 5) I page 190 in (1974 i i ii i i ii i 1 ii i1 i1 i1 (Paper by lAlto Block (B R Cot tine nf|Jama 1*7.74 I0SHA (P 5) _ i 17 i 14 1 i 1 _L_ l 5ft l 2ft \ l 1 11 1 l 1 L ( | 2ft ii ii UJ.M.n i | (NIOStt | 1 eaya l | 2ft .<19.7|)| 1s l1 119*12.71 | Yea Yea i 1 | 1 i i 1 1 1 1 |Pot Cleaner |(Cf Mock) 1 1 1 |Pot Cleaner ILoulavl1!e 1 1 (K,f 1 lAlao Block IJAMA 1.7.74 If 53 t |Ref I i i ii i |(Cf Block) |Courier (Alao Block i i ii i i ii 1 1 11 i1 t1 11 IJnurnal (02-09-fiO ! l 43 l 15 1 15 107.01.68 | Yea | |Pot Cleaner I Ret l i i ii ii i |(Cf Mock) i1 |Alao Block 1 i 1 ii 11 1 52 t 20 i | 20 109.04.64 1 i 11 Yea | t |Pot Cleaner |(Cf Mock) Iftef 1 (Atao Block i 45 i 12 i i i i i 1( 1 1) t 12 I24.07.2S | i 11 t 11 i 11 i 11 Yea i 1 | i i i i !______________ 11 11151 Air Parcel 1 (Pot Cleaner |(Cf Mock) 1 i 1 (Ref 1 + ILoulavl He IT1 a. 21.7.75 |Retired Aprl\ 11974 i L t 45 l 24 i 11 . __L 1 I1 1 17 |21.01.6ft | Yea i i 1 1 1 1 1 1 |Aten Block j_______ 1 I Ref 1 1 .1... ( 41 l 15 l t 1 ii l (i i ii 1 15 I29.nn.6l 1 1 11 1 !1 Tea i t i | 1 1 1 1 1 1 ( 1 | i _L_ inti i t I l 1 11 11 ..L J-........... . -L................. i .1______ 1 008?8? genc IMPERIAL CHEMICAL INDUSTRIES PLC PETROCHEMICALS AND PLASTICS DIVISION LIVER Angiosarcoma Cases - (Review Date: 15 April 1981) UK sraCen of dates DAY - MONTH - TZAR USA Sheet 2 Page 21 1 iI I 1Z ii i 1 iI I 1l RY AND t NAME OR | DATE OF I KEHCE | INITIALS | BIRTH J ^ COMPANY ti I i |5i6 | T ! B i t1 i i1 1 1 i FIRST VC 1 DATE OF I ACE AT | YEARS OF | FACTORY i EXPOSURE | DIAGNOSIS | DIAGNOSIS 1 EXPOSURE TO t ti i in 1 H 1 12 i n 1 14 | 1 JL1 1 11 YEARS OF 1 DATE OP | HISTOLOGICAL 1 ESTIMATED | EXPOSURE | DEATH | CONFIRMATION | EXPOSURE 1 OCCUPATION 15 OTHER CAREER i 1 16 1 1 OTHER | COMMENTS 01 1 t i i i1 i1 ii it ti l>9 JRnyiamid 108.11.11 | BFC ICetCle|Finger? 1 1 l 1 JLolaI vide 1i i ii t ti i 28.05.45 | 01.01.14 i1 i1 ! i i i i l | DIAGNOSIS 1 1 1 1 | 29 i i i i I 1 1 24 III.01.75 t | 1 Yea | LEVEL J i i i | 2000 ppm 1 1 | .11 ii ii it ii ti it HIGHLIGHTS i i 1 |Ref l haa |wrong figures |re first i 11 1 lI i 11 I |I 1 1I i1 l i i1 l t i1 i i il i i i1 t i ii i leKpoaure* 1 1i i |Lonisv 11le | ii t |T1net | | 't i 129.10.74, | 1i i (12.1.75, i 11 i1 1 ii i 110,1.76 i t1 it t J______ i ti i 1 1 10 1 1I i1 i 1 II6.U8.I1 1 Goodyear (Niagara i 12*06,5l | Of).05.68 1 55 1 17 i 17 | in.05.68 1 He. i i i i i i f Ref 1 1 i "i i 1i i 1 1i ii 1 1 | IT.01.09 1 Goodyear (Niagara i 14.10*46 | 00.01.70 1 61 i n 11 !1 1 l 1i 21 |16.01.70 | Ye* i i 1j i i i _L i i t ! 1 |Ref 1 J______________ 1 11 t1 I 1 i 12 IFrancIa A 117.11.18 1 Firestone JPottatownl H.07.49 | Cl2.fl$.69 1 50 1 2fl 19 102.115.69 | Tee \1 JHlfth 10 yra|)0 yra m 1 |Mtlllty 6 (Ref 1 + letterl |Bachman i i i 1 i i i i 1 1 i 1 i i i i i i i i 1 Pa 1 1 1 1 I 1 t ix | i1 i1 i| i1 i| i| i i i i 1 i i | i Ireactor op. IServIce op. jof 26 April | i Knot eleaner]Bagger 11578 fra. i i 1* separate (Dryer op. IRunsel1 A Park | | i Icrew cleaned]St ripping op. | to J T Seawall| i i lautoclavea) (1 yra prior |of MCA i i| laervlca In | | i| (tyre plant i t ii 1i 1 i ii _!_ 1 11 n |Richard |0l.12.21 l ucc |E<lwa rd i 1 t1 1 1 |S Charle -1 11.12.42 | 00.05.74 1 52 1 32 t aton 1 i 1 1 1 26 107.04,74 | | Yea i |2000 ppm 1 i i i i t i 1 |Charleston IDatly Hall ICIendenln i 1 1t i i i ii i 121.7.75 1i iI L. L i ii 1 1 uI i i t 11 11 11 i1 L1 1l t 1 11 i 1 li i I 1i I i t J. i. | ,t 1 ii t 1 ii i |DuMont | 1i i | fabrication i ti i lease ii t i 15 i 1 i i 11 l1 |1 I1 tt 11 I 1 1I i I 1I i t 1I 1 1 *t 1 I ii it i iHuhlout s ii i | f ahr1 cat Lon 1 11 1 | case 11 1 t I1 11 1 i 1________________ I 1 1 ! .! 1 i 1__________ 6ENC 008768 IMPERIAL CMEH1CAL INDUSTRIES PhC PETROCHEMICALS AND PLASTICS DIVISION LIVER Ang loaarcniaa Casea - (Review Date 15 April 1981) * OK Syaten of Hates DAT - HOHTII - YEAR USA Sheet! 22 1 tI J 12 ii I 1 iI 1 1I JOONTRY AND | NAHE Oft | DATE Or I REFERENCE 1 INITIALS ( BIRTH I NO i il i i JSA i i .L i jI 4 COMPANY 16 jJiaefl 104.11.27 BFG (Howard i l i i1 i i( i tI t iI i II i 11 i il 17 JPeerenbuon|06,05*3l I BKC i iI 1 1r 1 tt 11 .! _i 1 1 ii ia |Charlie (22.04.26 i It FG tArthur 1 i i ti i 1i 1 1i t 1i 1 li j______ -L I i 1( 19 IVIrgll 100.00J5 i HOC |CUrLatlan t i i1 i1 1 *i i ti 11 t 1i 10 i |ll.08.17 i Goodyear i 1i j 11 11 21 (Cheater (02.09*09 IJCG JllluVU i 1 i j I ) i 1 i ii 1 .!_____ _____ 1 ii i 1 t i f ti 15| 6 1 7 1 8 1 9 i 10 I u 1 12 f 11 ) 14 11 1 1 1. _ . i | 11 1I 1 1 1 t 1 11 1 1 FIRST VC | DATE OF 1 ACK AT | YEARS OF i YEARS OF | PATE OF 1 HISTOLOGICAL 1 ESTIMATED | FACTORY | EXPOSURE | DIAGNOSIS 1 DIAGNOSIS | EXPOSURE TO i EXPOSURE t DEATH 1 CONFIRMATION | EXPOSURE | OCCUPATION it i 1 | DIAGNOSIS i 1 ( LEVEL | ii .L 1 fi ii i *1 i 1 ii ii i 1t t tt (Louie- 1 | OS.05*50 1 00.00.69 1 41 1 19 04 127.03.69 i Tea 1 i (1951-4 VCH Ivlllt | i t i i 1 J tpolyner- 11 i ( i 1 1 llaatlnn 11 t I i i 1 ii 11 i t 1 ii 11 i I 1 i 1 ii 11 t I i i 1 ii 1 |l.0l|]S~ (vllle 1i |i 1 21*06.55 1 11.10,74 .L l l 43 i.......................... L tl 1 19 l ______ 1 1 Yea 19 116.10.BO t on 11*10.74 i i i i i t ii 1 1t 1 but no r \ t1 t 1 I poat-orten i i ti ( il 1 I6.I0.R0 ii t l r l 1 ii JL i ( _L. 1 1 it 11 i l 1 (Avon Lake| 15.09.54 1 on.no.25 1 46 1 21 11 1 13 (02.11.75 1 Yea i (13 yr. i INivy ii 1 l i t 1 ]autocleaner| i i "1 ' l i 1 1 |9 yra on | ii t l t l ( l&atot (Tyre Store ii 1 l i l 1 (pleat leiaer( ii ( l t l 1 (A Carboaet I it 1 l i JL 1i l I loperatlon ( | 1| \1 J (S Chari e-| 00.00.43 1 19*06.75 I aton | i 1 60 t 32 i f( l 32 106.04.76 1 l1 Yea < 12000 ppn i i | i 11 i 1 11 1r 1 1 11 1 1 ( 1 11 ii ii 1 1 1 J1 ii 11 1 1 L 1l | ir 1i 1 Niagara | OO.mi.55 i 30.01.76 58 1 21 l LA IIO.Ol.76 Yea i i ii * 1 ii 1! 1 1 ii 11 i 1 |S Charia-| 00.12.44 1 R.rly rl 6/ 1 3U J aton | 1 l i (i l 22 (112.01.7 7 t 17 Yea i i i i i * 11 1 i ii 1l 1 l 1 ii ii 1 t 1 t tr .1L .1. .1. J. L_ _ ___L......... ........ Ii i 15 1 >4 11 1 1 OTHER 1 f OTHER | CAREER | COMMENTS | HIGHLIGHTS i 1t 1i li 1 IFron 1954 1 |Tabte 4 In lonwarHa In IWagoner |Arny and other|Teatlaony to | aervlce* (US Senate J46-50 Ar*y |Confirmed In i |H N Johnaon i 11cr ni.ns.77i it i1 i |Hr H N Johnson| i 1 letter of i |24.2.8I coiv* Jftrued Heath i |6 years after i (diagonals i1 i (Conffreed In i |H N Johnaon i |ltr 07.n8.7S i (Also Rolling i |St one nag* i |l5.m.7S i( i1 i1 t |Wl 11 taaieport i |Sun Caiette i 121 June 1975 1 |Chrleaton 1 (OaLIt Mall i (21.7.75 1 t1 i (NIOSII letter i (of 25.10.79 1 i1 i 128 yra with i (iicn ,t sc t |Ret tred I (New# release i 121.2.77 GENC 0087*9 IMPERIAL CHEMICAL INDUSTRIES I'J.C PETROCHEMICALS ANI1 PLASTICS DIVISION LIVER AnRluasrcoma Case* - (Review Date: 15 April I9A3) *tTK system of dates MAY - MONTH - YEAR USA Sheet 4 Page 23 11 1 12 t3 i 4 |5 11 JUNTRY and | NAME OR | DATE OF tEFERENCE l INITIALS | BIRTH _J 1 1 COMPANY | FACTORY NO i i t I ________! 'A l l i i 1 22 1 1 f02.10.23 l)FC 1 ll.outa- ii | v tile 11 i 11 i 11 1 11 11 t 1 11 i 1I i 11 1l i i 1l i 11 i I1 11 11 11 J 1 1 1 f1 1 1J 1 -i____ 23 | i. 100.00.23 Great (Fitchburg ti ii American JHaas. Chemical i !. 1 Company . t 24 1 Charles 117.05.17 IICC |S Charle- 1 Edward | | aton |Moore J i it i 11 i lI 1I it i i i ii i ii t it i ii i fI i ti i ii ri t i (25) i _ j.. t ... i i *i i ti i ii t | | Removal front ri Klster conf ii i .1 1 ,i 7.......... . 617 1 1 FIRST VC | DATE OF EXPOSURE | DIAGNOSIS t i i 1 11.07.47 l no.oi.7b i i t 1 i I i I I i I i l r i i i i \ 0ft.09.5SX Oft.04.73 T55T \ i i | 27.05.77 1 1 1 1 1 1 ) t t 1 1 1 1 1 1 | 1 1 1 t imed In R Kaminski let i .1_______________ i A | 9 1 io 1 r AGE AT ) YEARS OF | YEARS OF DIAGNOSIS | EXPOSURE TO | EXPOSURE | DIAGNOSIS 1 1 52 | 29 1 1 l j i t 1 1 1 1 i i 1 1 i 1 i i ( 50 1 15 1 J \ *0 t ~Ta 1 I I I I 1 ( 1 1 ) l 1 t 1 I 1 l l 1 I uf of 5 November 19R0 | ) t 2B | 14 1 24? Kniosii Isays 2b) i 1 11 II | DATE OF | DEATH HISTOLOGICAL CONFIRMATION |04.12.7fi Yea (04.04.73 Yes I27.05.7f Cholanglosarcoma (R Kaminski 26/2/79) 1 | 1M i 1 16 1 1 | ESTIMATED 1 | EXPOSURE | OCCUPATION | LEVEL i i 1 15 1 ( OTHER CAREER highlights ( ( 16 othlr COKHF.NrS 1 I i | 1 1 (Lou 1 a v 111 e \ 1 |TInea 26.1.76 f i laald be was | i (Che 1Oth AS | i Ivfctla.at | 1 | Rail# Lane of | 1 (whom ft had | i (died by J i (26.1.76 | i (In hta letter 1 i (of 16.09.fll I t (Dr M N Johnson 1 i [confIrma this | i (la the | 1 lease deacrlhedl 1 |bf Dannaber I i ITambnrro 6 Yat i | in r.l> I960 | t |Am J Medicine I i |Vo1 70 p2fl0 | i | | |Medium to thigh for | 24 yra t JI94I-65 non- mfTf wee IN H Wheeler | |aolvent off end on lletter of | (vinyl reeln labourer 11 ft.8.77 to j (unit and ni9-il e.y |J Stafford | Mlaperalon have heen Iftlvea details ( |vinyl realna exposed as |Rose Xamlnskl 1 limit flrat reactor lletter of | |aa fitter cleaner 126/2/79 | (lie I per, then 1943 became |R Kaminski j (shift shift fitter |<5 Nov I960) l |ut 111Cy man (946 became Isiiftfteeta that | i ahlft utility |Hi OSH will | t man Iretatn on 1 i 26.06.65 freglnter since! i employment wanfthla neoplasm \ i terminated |may be anaoeJ-l i | ated with ASI.. 1 i J 't t i i i ||t N Wheeler (lattar of 120/2/79 nd fRose Kaminski lletter* of 126/2/79 ind 15/11/60 I 1 | 1 \ 1 | SENC 003770 IMPERIAL CHFHICAL INIWSTRlftS PLC PETROCHEMICALS AMD PLASTICS DIVISION LIVER Anglosarcona Casee - (Review Outer 15 April I9ft3) system of dates DAY - MONTH - YEAR iisa Sheet 5 Page 24 1 11 2 :OUNTfty AMU t| NAME DR KEKHENCE { INITIALS NO i JSA i } DATE Of HlRTH 4 COMPANY 1 1 5 1 1 6 7 1I factory 1| FIRST VC EXPOSURE DATE OF diagnosis 1 1 ___ i 11 26 (John terry fl7.07.21 RFC l(*oule~ | 03.10.47 oo.nn.77 i I 1 1 1 v 11 ] e i i i | i i i {up to 2 years after death) i 11 1 it i ii i ii i ii I ii i ii i it 1 11 27 i|J L 11.05.16 MCC tIS Chflrle-|i 01.07.41 30*11.7R |Forrest 1 atoll | i ii 1 it t ii i ii i i> u 1 1 i Tocrr UCC i13 Cliarl-|t no.04.(4 03.11.78 1 aton | S-' 24 ii i 12.10.67 UCC iIS Charla-Ii on.oi.42 nn.oCTo 1 etnn l 1 1| 30 i |WYK 22.ll7.2i Tenneco i| FJenlngtoni 11.06.64 30.l2.fl0 i Chesites1 a i i i it i ii i it i ii i ii 3l i i Of. 11.IT UCC iIS Charl.a.-|i TOOf ni.rm.fti 1 I aton 1 1 ii | || 1 1| 1 (| i 1I | 1| | || | I| i ii | 1I I 1| 1 11 | i* _______ i ii ft 1 1 9 1l 1 io l 11 AOF. AT DIAGNOSIS 1 |1 YEARS OF EXPOSURE TO !| | YEARS OF EXPOSURE lJ 1 DATE OF DEATH i DIAGNOSIS i ii i 1 52 l (death) i 1 i i l l 1 i 1 1 t 1 i 2fl (death) 62 i i i i 1 1 1 61 ii i --n-- 1 i i I 5ft ti i 1 i i i i ST Ll ' I 1 | 1 17 34 1ft 17 TT 1 1 I I l | 1 l 1 1 I Lft 111.02.7 5 11 11 t1 11 11 i1 i1 i1 11 t1 i1 i1 i1 i| 20 1(25.11.7ft Kniosii laaya 27 1 i land C i (Dally Halil 125) i 1i 1----1 11 is 1 i l03.ll.7T 1 joi.oi.flo l | i is 1)0.12.80 i1 i1 i1 i1 i1 i1 1---- FT" 102.04;42 l1 11 11 11 |1 11 (1 |1 11 l1 l1 l1 11 11 11 i 12 1 13 14 HISTOLOGICAL J|__ES_T_IM_A_T_ED_ CONFIRMATION 1 EXPOSURE OCCUPATION 1 LEVEL 15 1 OTHER | CAREER | HIGHLIGHTS 16 OTHER COmENTS l Yea 1 Exposed In Various Joha |k KamLnakl laone degree In PVC lletter of |to 22 plauta fro* 126/2/79 .n4 Ichealeate cold row* to JProf. Taahorr |hut main paste lletter of (exposure recovery to 19/1/79 |waa to VCH. PVC charging Iprobahly operator to i m si, | paste charging. i i in August 1865. | ?i* minuted Yea i il 1 1 11 m*h employment Jan 1966 Operator to Exposure In |R N Wheeler 10.10.76 hulk and lltr of 4 Jan dlaperalon PVC||979 and manufacture (Charleston |Dally Hall | (30.11.7ft and l Yea I l I Yea 1t| 1R Kaalnekt 126/2/79 |R Kaminski lletter of 16/4/79 |R Kanlnahl ll.etters of 1 Yea l(6 - Unknown Maintenance 119th June I960 |6 5th Nov 19A0 (9 - Mlnlnal Mechanic i 6 yra i Etaewltere t| H1 IolTler houae| i Operator Yea i|Hlgh (_R_u_t 9 rr. Chemical Froai 1959 to |Dr Dacey (not aa high Operator In 1976 AlIphatlcI letter laa reactor charge Ghentcal a 116,10,ft] and Icleaner reactor operator and |X H Vlieeler |would (experience) | Worked aa (labourer J f rom |iune 1941 fro* .lulf I9?6|1atter of to datn 19.11.61. Foreaao (Also Dr Dacey Al1phat1c (letter of Chenlcal Opera11 on 107.03.8) re |d*tn of death 11o Hay 1946 land nay Jhave |c)eanerl Ireacturn In 1 that time ... GEM 8 008771 IMPERIAL CHEMICAL INDUSTRIES ILIMITED PLASTICS 111 VISION LEVER Angloanrcoma CAeea - (Review HateJ 15 April 19R3) USA Sheet ft 'UK ayatem of Hate PAY - MONTH - YEAR Pago 25 1 L 12 13 1 1 1 OUNTKY AND | NAME OR 1 DATE OF REFERENCE 1 INITIALS 1 BIRTH | NO * * COMPANY 1 1 US 32 |C W f* 1 roux J22-02-0B | Monsanto 1 1 l i i i 1 1 1 US 11 I i i i i j i i i 1IS Fergueon1|OB-10-27 1 RFC JJnr i US 34 I i i 1 |Mr Synai 129-01-34 [ RFC 1 1 t i i i i i i i t i i i i i it 131 6 1i i i1 i 7 a 1 9 1 10 | H 1 12 i n 1 U 15 1 IS | 1t 1 J1 1 J 1__________ 11 1 | FACTORY 1 | FIRST VC EXPOSURE 1 1 (1 11 DATE OF | ACE AT 1 YEARS OF J YEARS OF | DATE OP | HISTOLOGICAL | ESTIMATED DIAGNOSIS 1 PTAGNOS IS 1 EXPOSURE TO 1 EXPOSURE | DEATH 1 CONFIRMATION t EXPOSURE 1 OCCUPATION OTHER | OTHER t CAREER 1 COMMENTS 1 ii 1 1 DIAGNOSIS i i 1 ( LEVEL i HIGHLIGHTS ii 1 ii J j______ 11 Springfield 15-10-51 00-07-79 1 71 1 2ft 1 | 14 1 117-05-RO 1| An eutopay i IThe death 11940-1951 (Information 1 | Haas i i i i 1 i i i i ii i1 ii ii ii |(ln PVC | lautoclave ( larea) 1 ti ii | was done end |certIf 1cnteJVarIona ]uhs | Immediate (gave |1n polymer 1 cauee of |Mr Girona* (manufacture | death given |ueu*t IftirrVAR ] foccupation lUfSTRF.X (given In 1 lletter of 24 | (February 1992 | Ifrom Dr f (Walter C j ti ii ii it ii ii i i | "Angiosarcoma "( aa "kettle|1951--19&4 i ti i ii (operator* JVartoua Jobe 11 n |tn and Iftarnea of 1 IMonaanto j (Springfield to] ii i1 i ii J"chemlcala (around PVC (Or A Nunn of l ii ii i ii (1 nduatry". leutoclavea IMonaanto 1 ii ii it ii i1 1 i ii i ii i i1 i I1W4-I971 i t IVarloue 1 cI erica! # |Europe. | I 1 i 1 ii i1 i i1 i |.1 oha In PVC tt ii i ii i |palymeriantJon ii ti 1i i i ii i ii i (facility/ i (Retired it f i ii t 101-03-73, 11 1 |Loulavitle 09-09-54"| M-fl5-ft2 1 54 1 2ft t 11 1 2ft |Allve 1 Yes i i 1 |Mult tple |Prof Tamburro it ii 1 1i i 1 loba (letter of ii ii ii 11 i1 iI i iI i i1 i i1 i 1 11 ncludlng | Pol y r (Operator 4 |12 Aug 1992 t (Or H N Johnson lletter of ii iI i ii i |Polycleaner. 12ft Feh 1993. 11 1 Louisville 1955 1l 03-N-A2 | 4fl 1 27 1 11 | 10 )A1tve |Ye 4 i i t (Pot if 1945 left RFC |Dr H N Johnaon ii ii 1l ii 1i 11 11 ii i i |Lelnmyoaarcnma| i i1 i i ii 1 i ii t jOperator 4 to become a (letter of (Autoclave Clergyman. 13 Nov 1992 ICleaner | Atld 1 1955-65, 12A Feb 1993. ii ii t ii i1 ii ii i ii i it ii i ii i ii ii i it i it ii i ii t1 it ti i ii 1 ii ii i ii i1 ii ii i ii t1 ii it > ii i1 ii ii i ii t1 ii ii i ii i1 ii ii t ii i1 j___ I... J. . QEHC 003?72 [MF'KB [Al, CHEMICAL INDUSTRIES PI,C. PETROCHEMICALS AND PLASTICS DIVISION LIVER Angiosarcoma Case* - (Review Date: 14 April 1983) Page 2 6 NTRY AND KERENCE NO NAME OR INITIALS DATE OK RIRTlI OSUUIA 05.04,1A Jugo Vlnil IS.II.11 Jugo Vlnil 21.12.It Jugo Vlnil 04 1 1.06.10 Jugo Vlnl 1 Split Split Spilt Split 14 15 I L6 EiRST VO EXPOSURE DATE OF DIAGNOSIS ACE AT DlAfiNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OK EXPOSURE DATE OK OF.ATS l HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER highlights OTHER COMMENTS 00.00.53 08.04.73 20 08.04.71 00.00.50 12.07.71 04*06.54 H.01.76 45 K' 22 12.07.73 Tee* 11 .01.76 15.12.56 03.09.78 18 03.09.78 VCK Production VCK Production I ISAKIC et al Jpeper Itnv Health | Perspective (Vol 17. |pp 189-192 (1976 j________________ t (Mn hie letter |of 3 Oct 1976 t |0r Sptrtaa of |NIOSN changed |tbe status of |Case 02 to VCH 1 product Ion lenployee. |Hr Splrtaa laleo notified |a new Case 03 |alao a VCK (product Ion 1 worker I___________________ I |Roac Kaminski If.etter of II 9 tli June 198 land 1ARC |letter of |J April 1982 I I I ...i. ..... i.. _______ i. ..i. 6ENC 008773 TABLE 1 (Review Date - 15 April 1983) Incidence of ASL Cases Per Annum 1955 6 7 8 9 1960 1 2 3 4 5 6 7 8 9 1970 1 2 3 4 5 6 7 8 9 I960 1 2 3 Total Ry date of death 1 0 1 0 0 0 1 1 0 1 0 1 1 5 3 2 3 ,-5 7 6 11 11 9 10 5 10 4 1 1 17)0 N.B. 1 Does not include Italian 01 but does include German 03. 2 The 1977 total Includes US case 24 which is a CholongJosarcoma. 3 The 1902 tornl does not Include US 33 and 34 who are alive. Page 27 GENC 008774 Distribution of ASL Cases by Country USA W Germany France Canada UK Sweden Yugoslavia Italy Czechoslovakia Japan Belgium Norway 31 *** 21 If * 14 10 8 5 **** 4 It A ** A 3* 2 2 1 1 TABLE 2 (Review Date - 15 April 1983) Page 28 Total 102 * Omit ItOl - atypical case of PVC bag extruder. ** Includes GE03 aerosol can filler. *** Includes case US 24 which was diagnosed as Cholangiosarcoma & US 33 and 34 who are ALIVE. **** Includes one monomer worker. ***** Includes two monomer workers. l.e Western Europe North America Rest of World 53 41 8 Total 102 GENC 008775 Pattern of ASL Casea by Factory TABLE 3 (Review Date - 15 April 1983) (a) W Europe Of the 53 cases In W Europe, 43 have occurred In clusters at 10 factories. Of the 21 German cases, 18 have occurred In clusters at 4 factories. ASL Cases Kemanord, Sundsvall PCUK, Rrignoud Dynamlt, Troisdorf Chloe Chlmie (Formerly RP), St Fons Wacker, Burghausen CUIl, Marl 1CI, Hlllhouse BP, Barry Solvay, Tavaux Lonza, Waldshut 5 5 10 5 4 2 2 6 2 2 43 Page 29 NB: There are 31 pre 1962 PVC plants in W Europe; 18 of these have had ASL cases (Ref Table 8) (h) H America Of the 41 cases in N America, 36 have occurred at four factories out of a total of 49 factories - In N America 40 plants have not had ASL cases. BFG, Shawlnigan BFG, Louisville UCC, S Charleston Goodyear, Niagara ASL Cases 10 13 9 4 36 NB: There are 29 pre 1962 PVC plants In N America; 9 of these have had ASL cases (Ref Tables 9 & 10) (c) Rest of World The 8 ASL case9 are believed to he In I cluster of 4 and 2 clusters of 2 cases. SENC 0Q8774 TABLE 4A (Review Date - 15 April 1983) Page 30 Latency Periods (Years from first Exposure to Diagnosis) W Europe No of Cases Total Years Average Belgium 1 18 18 France 14 336 24 * Germany Italy 21 385 18.3 * 3 58 19.3 N America Norway Sweden UK 1 22 22 5 122 24.5 8 189 23.62 53 1130 21 .32 Rest of World US Canada 31 769 24.80 * 10 204 20.4 * 4JL 973 23.73 Czechoslovakia 2 30 15.0 Summary dapan Yugoslavia 2 4 _8 39 19.5 85 21.2 154 19.2 W Europe 53 1130 21.32 N America Rest of World 41 8 102 973 154 2257 23.73 19.2 22.12 GENC 003777 * Of tlie countries with 2>I0 cases, Prance and 1)SA have average latency period above world average and Germany well below. DISTRIBUTION OF LATENCY PERIODS TABLE 4H (Review Date - 15 April 1983) Page 31 0-9 yrs 10-14 yrs 15-19 yrs 20-24 yrs 25-29 yrs 30-34 yrs 35+ yrs Total Average Latency Period Belgium Canada Czechoslovakia France Germany 1 1 1 1 1 1 1 I 11 1 | Italy 1 1 Japan Norway 1 11 1 1 1 1 ( 1 1 1 1 1 1 ! i i [ i \ 1 1 Sweden UK USA Yugoslavia 1i JI 1 111 11 1i |1 1i 1i TOTAL 1i 11i 1i 1 1 J 31 1 11 1 11 1 4i i i i i i l i \ 1 1 2i i i i i 11 i i i ii 1 1 1 1| 1 4[ 1 9I 1 1| \ 1| 1 1 l 2i 1 21 f 7| i i i i 28 | 1 1 1 J 5| 1 1 ! 21 1 6* | 1 21 1 1| 1 l1 1 1 1 1 1 7j i 4| 1 1 28 | 1 1 1 1 21 1 1 1 41 1 21 1 1 1 1 1 1 1 21 1 31 1 71 1 1 1 1 20 1 1 1 1 1 1 I 1 1 11 1 1 1 I 1 I 1 1 i 1I i 2i i 41 i i i i 8i i 11 11 1 I 1 11 18 11 1 1 1 1 10 1 1 20.4 11 11 1E 2 11 15.0 11 i 1 2 1 1 14 1 1 24 11 11 1 1 21 11 18.3 tI ]1 11 3 n 19.3 11 i 1 1 2 11 19.5 1 1 11 11 1 11 22 j1 fi t 1 5 it 24.5 ) 1 11 1 1 8 11 23.62 11 11 4 1 1 31 11 24.80 1 1 11 11 4 11 21.2 11 11 II H 6 II 102 11 22.12 1 1 11 * Includes G 03 aerosol cnn filler GEHC 008778 (Review date 15 April 1983) Page 32 TABLE 4C LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE MAX POSSIBLE I YEAR OF 1 LATENCY PERIOD | FIRST EXPOSURE ! LATENCY PERIOD | ARITHMETIC MEAN 1 1 OF LATENCY PERIODS 1 11 11 43 I 1939 1 38* 42 I 1940 1 41 1 1 1 37,21,37 40 1 2 1 32,38 |1 1 203 33.83 1 | ~T 1 |1 39 1 3 I 28,14,32 I 1 1 4 1 28,11,24,20,24,34 | 679 26.12 1 1 5 1 27,22,28,29 | 26 1 1 6 1 21,29,31,26,28,15,23, | 1 1 1 30,35*** 35 I 7 1 29,24,29,28 I | 1 1 34 I 8 1 28,24 1 9 1 30,26,20 |1 | 424 - 23.56 1 | 1950 |1 1 26,22,31,19,23,14,33 | 1 19,28,17,28 | 18 1 1 30 1 2 1 21**,15 I 1 29 1 3 1 25,22,23,22,20 | 1 1 4 1 21,21,25,25,21,28***, | 1 1 1 22 | 538 m 20.69 1 I 5 1 22*23,24,14,19,21, | 26 1 1 27*** | I 6 1 21,12 | 1 1 1 25 | 7 1 19,17,15,13,16 | 24 1 3 1 18,18,15,17,20 | 1 1 1 9 1 16,21 I 328 = 16.4 1 I 1960 1 13,18 | 20 1 | 1 1 15,16,16,16,19,18,12 | 20 I 2 13,18,17,12 | 1 1 19 1 3 1 16,17 1 4 1 16,17 I 5 1 11 |1 | 86 - 14.33 1 16 1 1 6 19 15 I 7 1 14 1 8 1 1 ;i | 1 1 1 1 91 11 I 1970 1 1 1 VIOLA I 11 10 1 2 1 9 1 31 11 11 I 1 MALTONI 1 41 1 GOODRICH I TOTAL 1 102 I 2258 22.13 ! 11 ! 102 1 * Cholangiosarcoma ** Aerosol can filler *** US33 and 34 still ALIVE PJST80061400,11/WPX7-2 6ENC 00S77? (Review date 15 April 1983) Page 33 TABLE 4D LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION MAX POSSIBLE | YEAR OF | LATENCY PERIODS IN LATENCY PERIOD | FIRST EXPOSURE | WESTERN EUROPE 1 NORTH AMERICA I ROW 1 43 | 1939 1 1 1 1 38* 1 1 42 | 41 I 1940 1 1 37 1 1 21,37 1 1 40 | 39 1 21 3 I 38 1 32,38 1 14,32 1 1 1 4 I 28 1 11,24,20,24,34 1 1 5 1 27 1 22,28,29 1 1 35 1 6 | 21,29,31,33 7 I 29 1 26,28,15,23,30,35*** | 1 24,29,28 1 34 | 8 I 28 1 24 1 1 9 I 30,26 1 20 1 1 1950 I 26,22,31 1 1 I 19,28 1 19 1 17,28 1 23,14 1 30 | 2 I 21** 1 15 1 29 1 3 | 25,22 1 23 I 22,20 1 4 I 21,21,25,25 1 21,28*** I 22 1 5 I 22,23,24 1 14,19,21,27*** 1 1 6 1 21,12 1 1 25 1 7 1 19,17,15,13 1 1 16 24 | 8 I 18,18 1 15 1 17,20 1 9 I 16,21 1 1 1 1960 1 13,18 1 1 1 I 15,16,16,16,19,18 1 12 1 1 20 | 2 I 13,18,17 1 12 1 19 I 3 1 16,17 1 1 1 4 I 16 1 17 1 I 5 I 11 1 1 1 6 19 1 1 15 | 71 1 1 14 | 8 11 19 11 VIOLA 1970 1 2 1 1 MALTONI 3 1 1 1 1 1 TOTAL 1 53 1 41 18 * Cholangiosarcoma ** Aerosol can filler *** US33 and 34 still ALIVE PJST80061400,12/WPX7-2 GENC 008780 (Review date 15 April 1983) TABLE 4E Page 34 PLANT START UP DATE LATENCY PERIODS OF ASL CASES NO OF CASES AVERAGE LATENCY PERIOD 11 I LOUISVILLE 1 19407 I 12,14,15,19,19,20,24,27,28,28,28,29,29 1 iI SHAWINIGAN 1 1941? 1 11,12,14,21,22,23,24,24,26,28 1 l1 S CHARLESTON 1 1939? 1 24,30,32,32,34,35,37,38,38 1 1 TROISDORF 1 1954 1 12,13,16,16,17,18,19,21,23,25 1 11 1 I 13 | 1 10 | 1 91 1 10 | 1 22.46 20.5 33.33 18 PJST80061400,13/WPX7-2 (Review date 15 April 1983) TABLE 4F Page 35 LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT YEAR OF FIRST | 1 EXPOSURE | S CHARLESTON I LOUISVILLE 1939 I 38 1 1940 1 1 1 1 37 1 2 I 32,38 1 3 I 32 1 4 1 24,34 1 20 51 1 28,29,27 6 I 30,35 1 71 1 29,28 81 1 24 91 1 1950 1 1 19 11 1 21 1 15 31 1 41 1 28 51 1 14,19 6I 1 71 1 81 1 91 1 1960 I 1 11 1 21 1 12 PJST80061400,14/WPX7-2 1 SHAWINIGAN 1 TROISDORF 1 1 21 1 14 11,24 22 26,28 24 1 1 1 1 1 1 1 1 1 1 1 23 1 1 21,25 1 23 1 12 1 13 1 1 1 12 1 16,16,19,18, 1 17 1 GEt-iC 00 878 (Review dace 15 April 1983) TABLE 4G Page 36 PLANT 1 I SUNDSVALL 1 | BRIGNOUD 1 | f | | ST FONS | 1 | BARRY 1 | I1 I BURGHAUSEN | i | NIAGARA i | 11 I I SPLIT 1 | 11 START-UP DATE 1945 1950 1939 1948 1933 1947 1941 1 | 1 1 1 | l I l I i I 1 1 I 1 LATENCY PERIOD OF ASL CASES NO OF AVERAGE PERIOD CASES 16,19,27,29,31 11 1 5 I 24.4 years 11,16,18,26,30 11 1 5 I 20,2 21,28,29,37,38 11 i 5 I 30,6 9,17,18,28,31,33 i 1' 6 1 I 22.66 17,21,22,25 11 1 4 I 21.25 15,17,21,23 i 1 4 1 19 II 20,20,22,23 11 1 4 I 21.25 11 PJST80061400,15/WPX7-2 (Review date 15 April 1983) TABLE 4H Page 37 LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT YEAR OF | 1 1 1! 11 FIRST EXPOSURE | SUNDSVALL 1 BRIGNOUD 1 ST FONS 1 BARRY 1 BURGHAUSEN 1 NIAGARA 1 SPLIT 1939 1 1 1 11 11 1940 1 I 1 i1 11 11 t 1 37 1 1 11 21 1 1 11 11 31 I 1 38 1 1 11 41 1 1 11 11 5 I 27* 1 1 11 11 6 1 31 1 1 29 1 1 1 15,23 1 7 I 29 1 1 11 11 81 1 1 28 1 i 11 91 1 26,30 1 1I 1I 1950 1 1 1 1 31,33 1 1 1 23* 1 1 19 1 1 1 28 1 1 17 1 21 1 1 11 I1 31 1 1 1 1 25 1 1 20 41 1 1 I 1 21 1 1 22* 51 1 1 1 1 22 1 21 1 61 1 1 21 1 i 11 71 1 1 1 1 17 I 1 81 1 18 1 11 1 1 20 91 1 16 1 11 1 1! 1960 1 1 1 11 1 11 1 1 11 11 21 1 1 1 18 1 11 31 I 1 1 17 1 11 4 1 16 1 1 11 11 51 1 11 1 1! 11 61 1 1 19 1 11 * Monomer workers JS/DJS/DSO 16 12 April 1983 PJST80061400,16/WPX7-2 GENC 003784 TABI.E 5 (Review Date - 15 April 1983) Page 38 Annual Incidence of ASL Cases (Date of Death) by Geographical Area 1955 7 1961 2 4 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 1983 TOTAL l l 11 i Western Europe | North America | Rest of World ( Annual Total 1 l 11 i t1 i i1 1 11 1 f1 ( i1 i i1 t |1 1 i1 i |1 1 112 t1 t i1 i1 l |5 12 i1 l f 1 1 11 i5 13 i2 11 12 1 13 i4 i1 ( f5 11 14 1 318 (3 \2 i -( 5 1 6 1 4 i i i 11 I 6 ( 3 i 2 | 11 16 1- 3 9 I 7 ( 2 | 1 | 10 15 | 1 "15 18 (4 t ~ t 10 f 4 1o 1 -| 4 1o |1 | nil to date | 1 I1 j nil to date 1 nil to date t 1 ( 53* i 39** 1 8 | 100 * Includes G03 aerosol can filler hut omits It 01 bag extruder ** Does not include US33 and 34 still alive. I Cumulative t 1 Total l Key Events t i11 t2 1 t31 14 f i t t i i i81 I7f 1 ( 1 12 ( 1 15 1 17 1 20 1 25 l 33 I 38 I 49 i 60 1 69 t f 1 i 1 1 t 1 t i I Viola 1 1 1 Maltoni ( Goodrich 1 1 1 t 79 | 84 1 94 I 98 I 99 1100 1 1 ( 1 1 ( t l 1 1 t t 1 1 UENC 008 (Review date 15 April 1983) Page 39 TABLE 6 ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING IT01) I KEY 1 I EVENTS 1 1 1 1 1955 16 17 18 19 1 1960 11 12 13 14 15 16 17 !8 19 1 Viola 1 1970 11 1 1Maiton! 1 2 3 1 Goodrich 1 4 15 16 t7 18 1 19 1 1980 11 12 13 1 Total 1 I WESTERN EUROPE 1 FI 1 G1 | Swl r G2 I Nl,Sv2,UKl,It2 | G3** | G4.G-5.UK3 1 F2,F3,G6,G7fG8,It3 1 Bl,F4,F5,F6,F7,Sw3 1 F8,F9,G10,Gll,G12,Sw4 1 F10,F11,G9,G13,G15 | G16.G17 1 F12,F13,UK4,UK5,G18 1 UK6, UK7,G19,Sw5,G20,G21 1 It4,F14,UK8,G22 | UK09 1 53 11 1 NORTH AMERICA | REST OF WORLD 11 1 1 Cl 1 1 1 1 C2 1 1 I 1 11 1 1 US8 1 1 1 C3 1 1 1 US5 1 | Cz2 11 11 11 1 C4,C5,US4,US7,US10 1 US12.US16 1 US11 1 C6.US2 1 1 i t 1 C7 1 C8,US1,US3,US23 1 1 Y1,Y2,Czl 1 C9.US13 i US6,US9,US18,US26 1 1 Japl 1 US19.US20.US22, | Jap2,Y3 1 C10.US21.US24* 1 US27.US28 1 | Y4 11 11 | US17, US29, US30, US32 1 1 US31 1 1 1 39*** 1 18 1 V. 1 J * Cholangiosarcoma ** Aerosol can filler *** Does not include US33 and 34 still ALIVE PJST80061400,1/WPX7-2 GENC 008786 (Review date 15 April 1983) TABLE 7 Page 40 ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING IT01) ~ KEY | EVENTS | 1 I WESTERN EUROPE 1 | NORTH AMERICA 1 | REST OF WORLD! 11 1 1 11 I 1939 1 I | US24* 1 1 I 40 1 1 1 | Frl 1 1 21 I | C3.US27 | US13, US29 1 1 1 1 3 I Frl4 I C2.US19 1 1 4 |UK1 1 5 I Sw2 1 6 |Frl,Fr3,Sw4 I Cl,C5,US5,US7,US28 1 I C4.US3,US9 1 | C7,C9,US8,US11,US21,US31| 1 7 I Sw3 1 8 |Fr9 I C6,US22,US26 I US1 1 1 1 9 |Frl2,Fr4 I US12 1 1 50 |Fr7,Nl,UK8,UK9 I US16 |Y2, Cz2 1 1 ISwl,UK5 | US10, US32 1 1 2 |G3** 1 3 1G15,It3 I US4 I CIO 1 Uapl.Yl 1 4 |G7,G8,UK4,G19 I US18,US33*** |Y3 1 5 IG11,G16,G18 1 6 IFR10.G1 I 7 |Fr8,G4,It2,G2 I US2,US17,US20,US34*** 1 1 1 1 [ Czl I 8 |Fr6,B1 I US23 | Jap2,Y4 1 9 |Fr2,It4 1 1 60 IG5.G13 1 1 1 |G9,G10,G12,G17,G20,G22| C8 1 2 |G6,UK6,G21 1 US6 1 3 IFrl3, UK7 1 1 4 I Sw5 l US30 l 1 1 1 1 l 1 5 1 Fr5 1 6 |UK3 1 1 1 1 71 1 81 I 91 Viola | 70 1 |V 1 1 1 1 1 1 1 1 11 1 11 1 | 2| | || Maltoni | 31 1 1 11 1 1 1 Total |53 1 41 18 11 1 1 * Cholangiosarcoma ** Aerosol can filler *** US33 and 34 are still ALIVE PJST80061400.2/WPX7-2 (Review dace 15 April 1983) Page 41 TART K 8 WESTERN EUROPE PVC PRODUCERS - START-UP DA1ES vs ASL GASES (CMOTTOG G03) START-UPI COUNTRY NAME | OCMPANY NAME | LOCATION ASL CASE NLMEER I YEAR CF YEAR 1931 1933 1 IWest Germany |West Germany 1 |BASF IWacker 1 ILudwigshafen IBurghausen 04,07,11,15 1 1st Exposure 1 157,54,55,53 1938 I Italy 1939 (France IMontecatini |Acna I Rhone Poulenc |St Fans 1 03,09,10,11,14 146,48,56,41.43 1940 (United Kingdom!ICI 1940 I United Kingdcmlld |Runcorn IHillhouse 01,04 1 144,54 1945 I Sweden IKemanord |SundsvaIl(Stockvik 01,02,03,04,05 151,45,47,46,64 (Switzerland |Lanza ISios 1946 IFrarKe IRhone-Poulenc IRousilloa 01 1 146 1947 (Italy | Mooted!."son |Porto Marghera 02 157 1948 lUnlted KingdanIBP Cbem IBarry 03,05,06,07,08,09166,51,62,63,50,50 IWest Germany IHuls IMarl 09,10 161,61 1949 IBelgiua ISoIvic IJemeppe 01 158 1950 I France IPuk IBtignoud 02,04,05,06,12 159,49,65,58.49 |France IRhooe-Poulenc |St Auban 07 150 I Holland | Norway I Shell I Norsk IFerais IHeroya 01 1 150 1951 1952 1953 IItaly |Italy 1Austria IFrance 1Montedison IMontedison IHalvic ISoIvic | Brindisi ITemi IHalleln ITavanc 08,13 1 1 1 157,63 I Italy ISoIvic |Ferrara 03 153 1954 (Spain |Rio Rodano (United KingdomIBIP IWest Germany IHoechst |West Germany IDynamLt IHemani lAycliffe IGendorf ITroisdorf 18 01,02,08,12,16, 1 1 155 156,57,54,61,55,61,1 11 1 17,19,20,21,22 154,61,62,61 | 1955 1956 1958 1960 (Spain ISpain 1 |West Germany lltalv I Monsanto IberialMonzon IGaiqsa ISabinanigo IHispavic ITorrelavega ISolvay IRheinberg |S C Ravenna IRavama 04 1 1 1 1 159 1960 IWest Germany ILonza IWaldstut 06,13 162,60 | 1962 1965 1966 1967 (Portugal IFrance (Italy IWest Germany IWest Germany IFrance ICires IRhone-Ponlenc IPozzi IWacker IHoechst |AT0 Chimie lOporto IMontlucon v IFerrandina v 1Cologne 1 Knapsack(Frankfurt) 05* IBalan 1 1 1 1 160 1 1 1 1 1 | 1 1968 1969 1970 1971 1972 1976 1977 ISpain |Rio Rodano IMiranda de Ebro (Greece |Esso Pappas IDiavata Salonika IBelgium IBadiphQ 1 Antwerp IUnited Kingdom|Vinatex 1 Italy IRimLanca lltaly |SIR IStaveley ICagliari Sardina 1 Porto Torres Sar 1 United Kingdcmlld IRuncorn lltaly |S C Ravenna IRavmna ISpain IHispavic IMartorell I Sweden IKemanord 1Sterungsund 1 United KingdcmlHP Chem IFinland IPekema IBaglan Bay ISvartback 1 Holland IDEM IBeek Limburg IFrance |Soc Art D'vinylIMazingarbe ISpain IMonsanto Iberia 1 Tarragona 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 * Laboratory worker In Research Department PTtrrsnnAi/n aajpy7-? liEt IL- 003/ 33 (Review date 15 April 1983) Page 42 TABLE 9 USA PVC PRODUCERS - START-UP DATES vs ASL CASES |START-UP I COMPANY NAME | LOCATION 1 ASL CASE | YEAR OF YEAR 1 1939? |*UCC 1 1 S Charleston 1 NUMBER | 1st EXPOSURE 107,13,19,21,24,144,42,43,46,39, I 1 127,28,29,31 |41,44,42.46 1940? |*BFG I Louisville 101,02,03,04,05,148,55,45,52,44, 1946? 1947 1 1 I *UCC | Goodyear 1 l 1 Texas City | Niagara Falls 106,09,16,17,22,162,45,50,55,47, 126,33,34 147,54,55 I 108,10,11,20 1 146,51,46,55 1948 I Firestone I Pottstown 112 149 1950 I Uniroyal 1 1 Monsanto I Painesville 1 (closed 1975) ) Springfield ! 1 132 t 1 |51 1952 | Dow 1 BFG 1 Midland | Avon Lake 1 118 1 154 1953 1954 1956 1 Diamond | Deer Park 1 General Tire 1 Ashtabula I Air Products 1 Pensacola I Atlantic Refining I Brooklyn 1 Borden I Leominster I Conoco 1 Hebronville I BFG 1 Niagara I Great American 1 Fitchburg 1 1 1 1 1 1 1 123 1 1 1 1 1 1 1 |53 1 Plastics 1 Hooker 1 | Hicksville 1 i 1 1 1957 1 Pantasote 1 Atlantic Tubing 1 Tenneco I Passaic 1 Cranston 1 Flemington NJ 1 1 130 1 1 159 1958 1960 I Keysor Century 1 BFG I Air Products 1 1 Saugus, Cal I t Watson, Cal 1 1 Calvert City 1 I (closed March 1982) 1 1 1 | 1962 1963 1965 1966 1967 1 Borden 1 Illiopolis 1 1 Tenneco I Burlington NJ 1 1 Conoco 1 Aberdeen, Miss 1 1 Stauffer I Long Beach, Cal 1 1 Conoco I Assonet, Mass 1 1 Ethyl 1 Bacon Rouge 1 I Diamond 1 Delaware City I 1 General Tire/Pantasl Mt Pleasant W Va 1 I BFG 1 Henry, 111 1 1 Stauffer I Delaware City 1 1 Allied 1 Painesville, 0 1 1 1 (sold to Robintech) 1 1 1 1 1 1 1 1 1 1 1 | I Hooker 1968 1 Firestone 1 Burlington NJ 1 Perryville 1 1 1 1 1969 1971 I BFG 1 Pedrickton NJ I Goodyear 1 Plaquemine 1 Olin 1 Assonet, Mass 1 (Formerly Conoco)) 1 Conoco 1 Oklahoma City 1 1 1 1 1 1 1 1 1 1 PJST80061400,4/WPX7-2 GENC 00878? TABLE 9 (Continued) Page 43 USA PVC PRODUCERS - START-UP DATES vs ASL CASES |START-UP | | YEAR | 1972 | | 1973 I [ COMPANY NAME Nat Starch Borden Robintech | 1974 | Atlantic Tubing | Shintech | 1975 1 Certain-teed I Georgia Pacific I Tenneco | 1979 | Firestone | LOCATION 1 | Meredosia, 111 I Springfield | Painesville, 0 1 (sold to Georgia 1 Pacific who I converted to 1 polystyrene) I Cranston RI I Freeport, Tex 1 Lake Charles I Plaquemine, La I Pasadena, Tex I Plaquemine ASL CASE NUMBER 1 YEAR OF | 1 1st EXPOSURE | 1 1 1 1 1 1 1 1 1 1 1 1 1 * My databank has no Information on UCC before 1946 or BFG before 1950 NB Some of the plants In this list were closed down, some have changed ownership over the years PJST80061400,5/WPX7-2 (Review dace 15 April 1983) Page 44 TABLE 10 CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES I START-UP | COMPANY NAME 1 LOCATION | ASL CASE I YEAR OF 1 YEAR | 1943 1(1941?) 1 1 | Goodrich 1 1 1 i Shawinigan 1 1 NUMBER 1 101,02,03,04,05 106,07,08,09,10 | 1st EXPOSURE 1 |44,43,4l,45,44. 147,46,61,46,53 1 1 11 ! | 1951 I Monsanto* 1 1 La Salle 1 1 1 1 1 1 11 1 | 1957 | Goodrich 1 1 Welland 1 1 1 1 1 1 11 1 | 1966 1 Esso 1 1 Sarnia 1 1 1 1 1 11 1 11 | 1979 | Diamond Shamrock Alb 1 Fort Saskatchewan 1 1 1 1 1 I1 * Terminated 1975 PJST80061400,6/WPX7-2 GENC 00o?Vl (Review date 15 April 1983) Page 45 TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES | START-UP | COUNTRY NAME | COMPANY NAME I YEAR 1 1 IPre 1939 I East Germany (State Company 1 1941 1 Russia (State Comps | 1950 I Yugoslavia IJugo Vinil | 1951 I Czechoslovakia I State Comps 1 1955 |East Germany I State Comps I 1956 I Rumania 1 State Comps 1 1957 (Poland I State Comps |Rumania |State Comps 1 | 1958 I Rumania 1 1 State Comps 1 1959 1 Hungary I State Comps 1 1961 I Rumania 1 State Comps 1 1963 I Yugoslavia lOhis I 1965 (Bulgaria I State Comps 1 1967 1 Poland (State Comps 1 1969 I Russia 1 State Comps 1 1970 I Rumania (State Comps I Russia 1 State Comps 1 1972 (Yugoslavia IVinilplastika 1 1975 (Czechoslovakia 1 State Comps |Russia I State Comps 1 1976 I Yugoslavia IHip 1 1977 I Rumania (State Comps I LOCATION 1 1Schopau (Vladimir et al 1 Split INovaky IBicterfeldt 1Icechim |0sweicim (Dwory) ITimaveni ITurda IRisnov (Berente Borsod 1Borzesti (Skopje I Varna ITarnow ID.jerjinsk IRimnicu Vilcea 1 Volgograd I Zadar 1Neratovice (Kalush Area (Pancevo IRimnicu Vilcea PJST80061400,7/WPX7-2 | ASL CASE ( NUMBER 1 1 101,02,03,04 |01,02 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ( 1 YEAR OF ( 1st Exposure ( 1 153,50,54,48 157,50 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 60'1'C 00 87 V 2 (Review dace 15 April 1983) Page 46 TABLE 12 JAPANESE PVC PRODUCERS - START-UP DATES vs ASL CASES I START-UP I COMPANY NAME I YEAR 1 l 1950 I Chisso Corp I Kanegafuchi Kag I Tekkosha 1 1951 I Mitsui Toatsu I 1952 I Mitsubishi Mon I Sumitomo Kag I 1951 I Denki Kagaku I Nippon Zeon | Toa Gosei 1 1955 I Ryo-Nichi I 1956 | Nippon Zeon 1 Nisshin Kagaku I 1957 1 Kureha Kasei 1 Shinetsu Kag 1 1960 I Denki Kagaku I Kanegafuchi Kag 1 1964 I Chisso Corp I 1966 1 Tokuyama Seksui I 1967 I San Arrow Kagak I Sumitomo Kag I 1968 I Ryo-Nichi I Shinetsu Kag I 1970 I Chisso Corp I Denki Kagaku I Kanegafuchi Kag I Kawasaki Yuki I Mitsui Toatsu 1 Nissan Kagaku I Shinetsu Kag 1 1971 I Tekkosha I 1973 I Asahi Glass 1 1974 1 Toyo Soda 1 1 1975 I Central Kagaku | Toyo Soda 1 1977 1 Unknown PJST80061400,8/WPX7-2 | LOCATION 1 1 Minamata '1 Osaka I Sakata I Nagoya | Yokkaichi | Kikumoto I Shibukawa 1 Kambara I Tckushima | Uozu I Takoaka | Takeo | Nishiki I Naoetsu 1 Ohmi I Takasago I Chiba I Tokuyama I Tokuyama | Chiba I Mizushima 1 Tokuyama [ Mizushima I Goi (Chiba) I Kashima 1 Kawasaki 1 Sakai I Chiba 1 Kashima I Yokkaichi 1 Hayatsuki | Sakata \ | Yokkaishi I Kawasaki , k I Yokkaichi I Kashima I ASL CASE | NUMBER 1 1 1 I 01, 02 1 1 1 1 1 1 1 1 1 1 1 1 1 1 11 1 1 1 1 1 t 1 1 1 1 ! 1 1 1 1 I YEAR OF | 1st EXPOSURE l 1 1 1 53, 58 1 ! 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 i 1 1 1 1 1 1 1 1 1 SENC 008793 * (Review date 15 April 1983) Page 4 7 TABLE 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS | START-UP| COMPANY NAME | YEAR I | 1953 1 Monsanto Mexica 1 1954 1 Policyd 1 1955 1 Geon Do Brazil 1 1956 1 Elehlor 1 1960 1 Electrochlor 1 Viplastic | 1961 1 Indupa 1 1965 I SOC Paramanga 1 PET Columbiana | 1966 1 Carburo De Col 1 1967 1 Plasticos Omega | 1968 1 Primex 1 1970 1 Policasa 1 Petro Dow 1 1971 1 Polimeros Mex 1 1975 1 Rico Chemicals 1 1976 1 Petroplas | 1977 1 Indust Resistoc | 1978 1 Huls Brasil 1 Polychem 1 Policyd | 1979 1 PET Camacari | LOCATION | 1| | Lecheria (Mexico) 1 | Mexico City (Mexico) 1 | Sao Paulo (Brazil) 1 | Sao Caetano (Brazil) 1 ICapitan Bermudez(Argentina) I | Mendoz (Argentina) 1 | Cinco Saltos (Argentina) 1 | Paramonga (Peru) 1 I Cartagena (Colombia) 1 I Medellin (Colombia) 1 | Mexico 1 | Puebla (Mexico) 1 | Managua (Nicaragua) 1 | Conception (Chile) 1 | St Martin Puebla (Mexico) 1 | Guyanilla (Puerto Rico) 1 | EL Tablazo (Venezuela) 1 I Tlazcala (Mexico) | Cubato (Brazil) 1 1 | El Salvador 1 | Coatzacoalcos (Mexico) 1 I Camacari Bahia (Brazil) 1 ASL CASE NUMBER 1 YEAR OF | 1 1st EXPOSURE | I 1 1 1 i i i i i i i i i i i i i i i i i i PJST80061400,9/WPX7-2 GENC 008794