Document jm5X0ze2kp57xMmevVy1x8BRO
AR17J6-033I
Feces3MMPerMothtoEocdDoDIlCfeoAvreLSlotDpumEdyPeAnNtRoM.TTeMt-Da6Eb3eNor1il6Tvis.a,1mtC7iv,OSeTtsRu-.6dP2yO9fR5o.A2r1PT,eETrf-T7luO1o3Xr2oI.o3C;cOtSaLTnOe-4sG1ulYfonate
SFfTetlhcuuieodssrysimtnuOeedbtAyajebnicsoatlldiiyvteteeis:ciaganlnaCelydhsetiosm. gisetnryerTaeteamspteociumseenfsofrodretvheelo3pMmEenntvairnodnvmaelindtaatliLonabaomraetothroyd of
Research O ient: 33SMMainCSt pPeenacuteilar,l,tMyBNuCihl5de5imn1gi4c42a3ls6Division
Sponsor:
33SMMainSCtpPeenacutiealr,l,tMyBCNuihl5de5min1ig4c4a2l3s6Division
Study Location:
33SMMainSCt tPernaatuteelgr,,iMcBTNuiol5dx5iinc1go4l42o7g0y-L3Sab-0o6rartooorym SB314
Study Director:
PA33TSMMhaoni.xd:nMiCrt6cePo5ewenal1dout-Mieg5clr,y7a.,Ml5BSSD-pe3Nueae1ilpcc56dtai15i.atn1,l/igF4sPCAt42ho2.XDr0p:-.o26rE5a1-t0e-72T3o3x-1ic7o7l3ogy
Study Toxicologjst. 3PDA3SMMhaed:iavn6nMCat5nnPre1acaade-tLu7iedclu3r,aR,e7MlBbe-D1ksNue3eeialpr75d,rt45ci.Mnh1F/g4SACT42Xoo2xr0:pi-6co2o5rEla1o-t-eg07i23Ts3to-x1i7c7o3logy
ProposeIInnd--SLLtuiiffdeeyESTtnaidmrtDeDlainatetee:::WMeodnndeasdyaNyoNvoevmebmebre2r22,149, 919999
RpTTroheoixgstioucsclotaoultoldogayrynywdLCiclalolbabmsGespipLlfieiaPerndfPocarreoms:gaerda"mCinlaPtshrsoeBc3eMdSuturSedt.yra"teagsiecxTploaxiniceodloingyTLOaXboSrOatPor0y9u5n0d, eSrtraadteegfiinced
^05962
T-63I6.17; T-6295.2I; T-7132.3; ST-41
DfuTarennsitHsMhaeIkaddeteehsr,nigiPtahilrf'-o.iNpcduaaurtmicitotyenR:N:e-sEptoNP2pFn7eFO-sr9EOifSb5ltSuEFi-l3o:iO,t9rPyPoS-eF3oLErOcfi:altSuaNisnooaaernnrosrduoo3lcwPMftoFanRnOCaeamhSnSeAgimudeltoifoNcoeant-tlhEhisceatDhnASyiovctllrii,adsFit,oeMPngo,i-cth3aT9ass2soi3pxu.rimceovSliooagultys;lyCLaAbS. # PFOSA: Perfluorooctanesulfonamide
Molecular Formula: NPF-EOtSF:OCSsEF:jtCO8SFO1z7TSC0"2N(CH2CH3)CH2CH20H PFOSA CsF,7S02NH2
Lot Number:
NPonF-EeOtsSFa:OmLSpolEet.:#L2o1t7s 30035, 30037, 30039 mixed and analyzed as
PFOSA: L -l0009
Purity:
PNaPnFFdEOOA9tDSFS9nSA%O:aCl:Sy>pstE9uei9s:cr%ehb9ny(83iaqG%)su.CdeaMesst(eSd1rme)d.teeinrtemerdminbieynde1db9Fyt-hGNaCMt t,hRGe(Cs2t/)aM.riSng, 1m9Fa-tNerMiaRl w, !aHs-oNvMerR
mbtQfc(hrIhrsoouaaaomnnatipnloctirh)htmto,hae)1pteeia8cytvhnso.le7iydmnb%algr0pnbal.oedCn2rasc8tFqnirh%tiu3cia)oa(h,lCnn()3'C,HtFw.1i5Ft21/aa%^3).ts)2xFi3v%6-CC-CeN5-xc.F((8MFCCo(%2CmFFRxF23pC+)3)coxl2Fr>-s-oSCCi3(ts0Ci(FFsoC2-F-(n-i(FCn2NaC2lt)FHeFy)r3gxe-22)Sr-s)(-aSux0tSt-0l-2iB0toS2s-2nNu0-t-Nt2hNaHy-anHlNH2tab2wlH2(ryIa(es2n(NnirAtsceeohlrrrpdeXnmheva4raeali)alv.leedd
i9cCpHCmo6p91PnmF8p%LFcu13Ce9ro6Sin(Hf/t5OMitPer)Sa2F.sSONt,Oito2HchNSnhe2s,Ha,pro612au,,,fc16rs1ti00ete,0y02rvi0ezopp0rappfatmmtpilhopoenomothPffoCeFoCfrsOtf7hFaFCSmew18A3FPiSHdF1Ose5SOaHs2Om.NS2BiSpAHNaOle2Hss,2eawNj5dm,1oH2op0u24nllepd,a0tpnhrb0emdee0vlseaopouappwfmlpemerdoorox9ffi,tm6h0ea0tely
005963 2
T-6316.17; T-6295.21; T-7132.3; ST-41
ItCSTShntethefoasoatbrtrearmimaslgitcaaetytmtteieC:orraniiDotasenltooridiwnccaiuslitslm:iwylonbeniltneslht:besatsetoiioskrenemdpwetttiiohlglnohbdtfelsiyl,eks.ceeopamtleopdnoasfititlireoo.nomortoemthpeerrcahtuarrea.cteristics that define A nim als:
IWNASSSdoptguereeuenmaicrgitacinibehfet:esit:GGGGic:rnaaRRRRaitttniOOOOiioandUUUUntiits:RSHPPPPoieaupnaxa342t1nrtri:..:a:looiaqgNPPcfnnuuoFFt-eeronEOOe1ttfatar2DSStoitFrAl,mmaleO,nwma,ae=nStnllan=e3em=rEyst3k3:,enn=t:39a-p1p1rowxeiemkastely 200-250g H usbanDEHdniroeyvut:i/srWionnEtoHtTAagaehmlnfDe:tmalreorvkoreorlrpwilua:ranaoeogndttmrfsnh:,aoTmowtMraueueicikrrlatnoelldtpatlbhoalideeseelfrocLci7snhtniMot2,ooudnWnudi-tv4yrroio3I8.da,fl5nusaFudanMfr,loidlahnyrouet1hutamh2aopseneiuhdw/dsaoRientafuyadietrmtecoilreSnaifsgwlt3w.ehri0rotlii/l-rlod7eibzma0ebar%kbopwltr,cetioolyaDlvmcmbilideeeim.etns,dieemstttuaoutpbomapollmlliioesramdfain1tbsc0tyaaaiegHndxeaclasirhbltaaiotnnugmes Dose anMdeDthoosdimuvseraAn1eoaos0golsgcilcll0inieuf/PhndrmgiammagvsrsdtLolaeawesgemcm)/aw1ioek1lai5pldfsn0gin-llibu05fldemndeerbgmmoiPeltspelrssteFlageid:edsOtrd/4riksofoaoo0oSugswfs0nreeiPm(d/dnnm2gDFog-e%rvusgOiodisenp/a;sukSdwoe2isogeAnp0ifrprtdeaP.thrmhnloFeUe5sgsgRpOienaos/saemSivytnofr-rarosaLofai/gurntNnk)mikesgdoewpg-eosnEesrinbfualn:otlootssdFfsbrpdiatoOeeiyhdynnnoeSpwzsgsorEtieieeironfs,ropinPgogsruasua.hFrpoetteoOs.fd4gfStiRNrhniwineanag-in2Eltdsrlsdo%tetruirueNFndcppTOy-geeEw3irSsuvotteEswFeeuielOnipna(lbg8lS2se8%raEife0nwoc;grei8leliel0ve
005964
3
T-6316.17; T-6295.21; T-7I32.3; ST-41
gbArTPfaeocayFwcrevsmOpeteiaoniueSgvignnmneeAlegep8t,2o(a0i5%22nn.%r%gmaeTttml;hsTw/2euwiek0nleeseggmmnieobrnnguo8o/l0u8dmsin0piyao.Ln2nw1)d%Rtoewhei1ngrTi-lowshldwuutabislegydelpehorzenpesnetrche8erseoeip0oiovasoftnreoyvfeoraedtaihnfhmbfPegiicyneFislxaetOdiutlmuiwdSscrmsyioAelo.lneolTbsvdcfoeeiiwnal1niatgo%detdrlsiaomynawtfibciaotnieechlniltfeseoobottneorrefearenep1/ted2sd%e,o%rwvtsfhoiiinalerlgnmo.readl ObservaBFCtrolieoidnqnyiucoWeaEfEOfoirnlmAieebcnaOanmisnymcdcegbehhaiihmeranscivndaatengoseanniirsdnna:dvilittwmmsg.earN:olitaaayliulllnlomapwbwinmnresiibidllao:rlleleorbsbrcnteewoooeworfiledPbAleueFsbintdegOhe.irhamvSsAeneaAdaaddclsridsrimdi:aiafati.timciolweynedidafllilooabfnrtieenmdldysaoiaynprctgr2raiisl-ofipiwtrcyoetiosldaltnbtodrdeenomasrdeetmoa.cyroebrn1iddtepiatdoynsadatsndtdohseneyo.taaArbellel Specim MeneCthoolldrttEfwsaUoAnwaawa5eererennlnecafaomoimiinrmapadclqdltncitzilliftlnahrmoupohseiyecobtbSrneefoevnrwnseapeaeeuspiretaanutslersaoit&eersadnnw.rnetryrtecrleiadwsdupll,icniaAliaEd.oflriomobnseilubtfqewTnalheatslrdblegu,eococdmtcaehelbeeionahoeseeddldebdfepnytldsuddioollClnslsndteiseowaesorepvi(faiecouesgeottrooewlidtrh:.utlcdaldirrolhlvlo6elimiyeflowgnTaeabocnlopccmnatetloehiatwtrrulacnlihfi-oloetlzlcmomloph7.)iepetebo2linpr0Anlwcnydaeewle0:aabltnlitb0eiioetabriCeselioilpace0lmnbaxmyflnttteeblocbfuedurxaCarotaeivldreislmiulsiv.nioOgrlotecnwbsefisdilsmdodr2pectuefeioaolereulsomaeaclwnomldrenntntfrwarbfaieicededioill1debietlnmyidogen5tgoaowbsthwdefoocwirtlte(oseoiouohvaatvt2uinurersaspegilemi3tshbnaapanihaca0neabdelnreneteonidnohetdeqamaarytawtlxehcdl.uwniebycicirrieeoddTamnoelsoeoidltbtiumlhonpfsashi1a.bdtrse,.ttsgt.eaoerhmo55eytDuisilzrTemflnir-lmyapuve1eaaracihninnegecitn0fa3nlelsrgroeoytrgamiffm.grownrroleearefdBroierrbleamtiadcomermldcliodmrler1oodnaeoyeredbb1co,istsfiddnehal0oiitd)tocwia.hedo0ngfwaeoysmDeleieen.axasdaziriduslsimegtlocwgOhiucrdhdabnipebinntfelleleleolleesgssrs.
bsliaqecusriitdfoicrneeidtdroaogtne-7dn0afyoCr2f-fbpootrusbrteidobcoihsoeecmhweiicmllailbcaeanleaaxlnycasisliyse.sdiK,s.wideniegyhsedfroamndafnlaimshaflsrozen in
005965
4
T-6316.17; T-6295.21; T-7132.3; ST-41
SpecimAtaeennlmal lHupyrosaiirnnsae,drtialhliynnedsgset:foesrcaeemdspaaltned-s7wt0hielClsbeienruptmhaecakSnetddralitinevgedirrcyfoTicroemxaiecntodalbosoghlyiiptLepaeabdnoatlroya:stoisryw.illFboer
T3K9SM3ter.5liesPEpBaHnhuuavolsn,inhrsMeoeAnnNNmv,oeP5e.n:hn5u.6t1Dea53l.31T--37e3c7h381n-6o0lo8g1y,
and Safety Services Facsimile No.: 651-778-6176.
twAhilelllkSbitderansteteoygrisecpdeTacoitmx-i7ec0noslCoag.nydltahbefroermbaioincdheemr oicfaslearunmalyasnisd. liTvheersweisllpbeecikmeepntsin
Tfohlleownusm: ber, type, and date of specimens to be generated for analysis are as
TABLE 1 -Spea m ens for EnvironmentalLab
Specimen
Collecton date
ELanbviSropnecmimenetnasl
Urine Feces
D12ay 1 post dose D10ay 2 post dose 12 10
Sera 2
10
SSptreactiemgiecnTs ax. Lab
Liver LKSeiivrdaenreys
2 2 2
10 10 1100
Total 22 22 12 12 12 1120
DAlaltraeAsunltaslywsiilsl:be provided for inclusion in the final report.
R estDcpiosoeslnaluensecinbtsaiinplLigetciuieinemsb-:lekifneesrsfaponerdcaiAmnaneldynrssei,swp. eSrfeoarcmatinwgiltlhbeenreecsrpoopnssieibsleanfdorcdoollseicntgintgheanadnismenaldsi,ng rAenvdierwewbeSfeoarceaat wfinilalldrreapftoartfiisnaislsrueepdo.rt and ensure the report receives appropriate 3M
0 5 9 gs
5
Signatures:
17).
DSSetru.ndiAoyrnDdRriereeswecatSorcrehacTaot xicologist
/
DAStdeuavdnaynnTaceoJd.xLTicuooexlobicgkoieslrto, gMisSt
T-6316.17; T-6295.21; T-7132.3; ST-41
_____ Date
___ ulaR/m Date
005967
6
T-63I6.17; T-6295.21; T-7132.3; ST-41
References: 1. Payf8Te1wr6,o,R6Y/C2e3ah/ra9Fr7ae.cet3deMirnizgSatSMiotuDndyoL.faFbSMMB-uD3il9dA2in3ng,aMl2y3tiix6cat-u2lrBRe-eo1qf1uL.eostts#5320408395.,3A00na3l7yt&ica3l0R0e3p9ofrotr# 2. KesLStnpaeebrc,otTrrao.tsoFcrloyupo/yrSoRcMheeMqmuDeisc-ta2l#3I65s-o32m0B3e-01r.1D3,iMDsterSicbepumetciboiaenlrtby1yA,11d99Fh9-e7Ns.iMveRs &SpCehctermosiccoalpsyA. nalytical 3. Payf5e9r4, 2R6.GRCe/pMorSt 9an/2a4ly/9si9s.o3fMPFSOAS&AC(LLa-1b0B00u9d).inSgA2&36C-2ABn-a1l1y.tical Request No. 4. KLSapebesotcntrreaort,oscTryo.p/CyShRMemeMqiucDaels-t2C#3h6a5-r92a4Bc2t-e61r.1iz3,aMStieopSntpeoemcfbPiaeFlrtOy2SA5A,d1h,9Le9s-9i1v.0e0s0&9,Cbhyem1HicaalnsdA1n9aFly-tNicMalR
5. CDC15hoe8rRro4po.mooRrasaettFoeqg.uArCeanshptaahl#ryyatAicGct-aer1olr5iuTz1pae2.tc5iho4nn.ooRlofegPpyFoCOrteSn1At0e/Sr7,a/9Bm9up,illaednsind, gTL-2e70t1t1e3-r21-a-1d2d9(e,LnC-d1Au0mT00Ct9o-) raenpdoTrtN1-0A/1-4/99.
00S968
7
