Document jm50dj6rdOXkXp0Y8k0o3jQB5

h CHEMICAL HYGIENE FELLOWSHIP KEY TO TOXICITY TESTS Number Name 1------------------- Peroral, single dose to standard rats 2 ------------------Peroral, single dose to other animals 3 ------------------Oral, subacute (usually 90 days or less) 4 ------------------ Oral, chronic (lifetime or 2 years) 5 ------------------Parenteral (subcutaneous, intraperitoneal, intravenous, etc.) 6 ------------------Skin Penetration, rabbits (24-hour contact under impervious sheeting) 7 -------------------Skin Penetration, rats (4-hour contact under impervious sheeting) 8 --------------- --Skin Penetration, subacute (usually less than 90 days), 1 hour contact, 5 days per week 9 ------------------ Skin Absorption (quantitative using tagged compounds) 10 ---------------- Inhalation, single--saturated vapor at room temperature, 20 to 25C -- 11 ---------------- Inhalation, single--mist (at 170C or selected temperature) 12 ---------------- Inhalation, single--fog (aerosol of 1 to 2 micron particle size) 13 -----------------Inhalation, single--measured concentration (ppm or mg/liter) 14 -----------------Inhalation, subacute (usually 90 days or less, 6 or 7 hours per day, 5 days per week 15 -----------------Metabolism, animal in vivo and in vitro on either biopsy or surgical specimens 16 ---------------- DOT Corrosive, 4-hr 17 ----------------- Rabbit Belly, irritation (single application, uncovered) 18 ---------------- Rabbit Belly, irritation (4-hour, eight applications) 19 ---------------- Rabbit Belly,' irritation via repeated application (3x daily for up to 3 days) 20 ----------------- Rabbit Eyelid, irritation, to classify bland materials 21 ----------------- Rabbit Cornea, volume and concentration to produce injury 22 ---------------- Rabbit Cornea, injury from vapor 23 ---------------- Mouse Skin Painting, for carcinogenicity 24 ---------------- Rabbit Ear, chloracne formation 25 ----------------- Guinea Pig, Landsteiner (sensitization via intradermal or topical appli cation) 26 ---------------- Human Patch Test (sensitization) 27 ---------------- Organoleptic Tests 28 ----------------- Wear Test (FDA) , miscellaneous irritation and wound healing 29 ---------------- Bacteriology, miscellaneous biochemical tests 30 ---------------- 3-Generation Reproduction and Lactation 31 ---------------- Teratology 32 ---------------- Mutagenicity 33 ---------------- Demyelination 34 ---------------- Cholinesterase and/or other Enzyme Studies 35 ----------------- Joint Action, to detect potentiation or antidotal response 36 ---------------- Literature Reviews 37 ---------------- Endotracheal Injection 38 ---------------- Pyrolysis (identification and toxicity studies) RNW 0424 January, 1976 * Chemical Hygiene Fellowship Carnegie-Mellon Institute of Research Carnegie-Mellon University 4400 Fifth Avenue Pittsburgh, Pennsylvania 15213