Document jm3OXdRjKb5dZ9rByedqbExgZ

' CroplL ife Bl ve wesarzamsoowo-osouzo CropLife Europe Scientific input to the consultation on the Restriction proposal on the manufacture, placing on the market and use of PFASs. Executive Summary: + A derogation for fluorinated packaging essential for sale handing of chemicals in regulated sectors should be introduced. + Additional information i provided on biodegradation of PFAS substances which are not + pDeerrsoigstaetnotnasndfosrpeicnitfeiremdaedsioatesoufsshoct uolpdeobfetihentrreosdturciectdiotnopraovpooisdal,unintended loss of derogated substances. + Tahmeenwdoerddintog afvooridtheunaicnttievnedesdublsotsasncoef isnafPelnaenrts ParnotdecstyinoenrgiPsrtosd,ucwthsicdheroagraetiaolnsso sshuobujelcdt bfeo + RInefgourlmaattiioonn(oEnU)th1e1a0g7r/o2n0o0m9ic importanceoffluorinated active substances is provided in support ofthe time-unlimited derogation. + A tme-unlimited derogation for PPORD and ot-yet-approved active substances shold be introduced to avoid unintanded los of inavation. + The universal PFAS restriction should removemanufacturefromthescoofphee restriction. + EshmoiuslsdibonoeasdtjiumsatteedsafnordmorlaepcourtlianrgwreeiqguhitretomaevntosidfordiPstoratedrnte4arparcgattiavtreisouna.bstpanches (and safeners) Table of Contents 1. Universal PFAS Restriction Scope........ S-- wm 3 IOOITOBES.....oo -- SR 3 Product and process orientated research and development (PPORD).................... 4 `Scopeofderogatiofnosr active substances. peel] Laboratoryuse............ Sr Fo ? ETE 2. Hazard Characterization 6 Biodegradation of PAS substances. 6 Tonnage and emissions -- molecular weight correction 7 `Specificcomments onAnnex XVreport wm-- ain? 3. Specific Information REQUESS ..... Til 1: Sectors and (sub-uses:.. FTI GR pil 2 Emissions in the end-ofife phase ............. ---------- 4 Impactson the recycling INAUSHY: we anil FrCarnocpoLpihoonEeuSroepceioniostf h|o9RBuussiGnuemsaCrodu|ro10f4B0rGusrsuelso|c|oBklgfuema|uGEr0o44p76e1@8e8r71oR pl|wie weowofcLuoot pgrablooPepauro essoo.npsoe.ouu ol 1322663 1550] Fax +322663 1580 5: Proposed derogation--s Tonnage and emissions: .......... --9 6: Missing uses -- Analysis of alternatives and SOCi0-CONOMIC ANAIYSI:........ nd 6.1: Fluorinated packaging in regulated sectors. 10 6.1.8: Annual tonnage and emissions. n 6.1.0: Key functionalities provided by PFAS. 13 6.1.0: Number of companies in the sector 13 6.1.0: Availabilty of alternatives 1 6.1.e: Future developmentofalternatives 1 6.1: Information on substitution requiring addtional time. 1 6.1.01: Costs. mn mm mn 6.1.62: Time... rm nm wn dS 6.1.0.3: Differences in functionally... sesminisns en 16 6.1.04: Benefits -- SE on 16 6.1.g: Information on substitution not considered feasibl............. en 16 6.2: Infermediates........ -- -- en 16 6.2.2: Annual tonnage and emissions .......... son S--] 6.2: Key functionalities provided by PFAS....... A. orn 16 6.2.0: Number of companies in the sector 16 6.2.0: Availabilty of alternatives " 6.2.6: Future development of alternatives " 6.2. Information on substitution requiring additional time. " 6.2.9: Information on substitution not considered feasible 7 6.3: Laboratory uses. 7 6.3.2 Annual tonnage and emissions. 1" 6.3.0: Key funcionalies provided by PFAS. 1" 6.3.0: Numofcbompeanires in the sector. SE enn 18 6.3.0: Availabilty of alleratves............. SE TY 6.3.: Future development of alternatives .. SE en 18 6.3: Information on substitution requiring additional time......... en 18 6.3.9: Information on substitution not considered feasibl........... en 18 `7:ecPoontoemntiicalandaelyrsoigsa:tions marked for reconsideration -- Analysis of alternatives and socio- 18 8: Other identified uses -- Analysis of atematives and SOGic-eCONOMIC ANAYSIS:............... 19 9: Degradation potential of specific PFAS sub-groups: i. - ST 10: Analytical methods: ....... SE SE won 2 4. ROGreNCES..... SE -- on 2 5. Annex 1 - Analyosftihse potential agronomic impact from the lossoffluorinated agrochemicals in the EU 23 6. Annex 2 OECD summary, Aerobic soil metabolism of "C-trfluoromethoxybenzoic acid... 23 7. Annex 3 -- Experimental work on degradationof CFs-containing molecules. 23 8 Annex 4-CropLife Europe information on functional groups .... en 23 22 9. Annex 5 -- Specific comments and addiional references linked tothe restriction report Annex B. 23 1. Universal PFAS Restriction Scope + rTehsteriucntiiovne.rsal PFAS restriction should remove manufacture fom the scope of the + Dsuebrsotgaantcieosn.s for intermediates should be introduced to avoid unintended loss of derogated + aThmeenwdoerdditnog afvooritdheunaicnttievendseudbsltoassncoef isnafPelnaenrtsParontdecstyinoenrgPirsotds,ucwthsidcehroagraetiaolnsso ssuhbojuelcdtbteo. + RInefgourlmaattiioonn (onEUt)he1a1g0r7o/n2o0m0i9c importanceoffluorinated active substances is provided in support + oAfttihmee-tiumnei-muinltiemditdeedrdoegraotgiaotinonf.or PPORD and otyel-approved active substances should be introduced to avoid unintended loss of innovation Manufacture AunsivaergseanlerPaFlAcSormemsterincttioCn.LEHissttorroincgallylyrReEcoAmCmHenrdesstrricetmioovnsalhaovfemafnocuufsaecdtuorne pflraocmintgheonstchoepemaorfketth,e oannldy.68T,hewrieth atrhee cfurrsrten(talsybeosntloyst)hbreiengREthAeCoHnlryesptrriec-tiRoEnAsCwHhiecxhamapplpel.y Wtoimlantuifsacbtaucrkeg:roEunntdr,iesan6, 62, the ucnopnrseecqeudeenncteesd. sIncoopuer oofpitnhiiosnPF"pAlSacriensgtrioctniotn,hethmearrekaeptp"eairssa1d0eqbueaatelatrogeacshcioepveefotrheuniinntfeennddeedd objectives. As a concrete example, Article 68(1) appears to exempt onsite isolated intermediates from the scope of REACH restriction: "The first subparagraph shall not apply to the use oaf substance as an on-site isolated intermediate." However, closer inspection of the Article 3(24) definition shows that "use" odkfeoeeapsinnngaor,ttitcirlneaoftarmcetancn,oyvfeiolrtinhmgearinnufufotaiccsotanutsriieon:n?e.r"sm,Aesraannassfraaensryufltrp,roomacoensnyseirncegos,tnrtfioacritminuoletnaortaiaponnpo,ltihceeordn,stmuoimxpmitanigno,unfp,arocsdttuuocrrtaiigneog,n appears as it may apply directly to onsite isolated intermediates. AS a further example, the Annex XV report proposes afer 18 months all manufacture cease. Derogations apply for various downstream uses. This presumably places a significant compliance {t`bhuerrndedanirneoocfntpslotythefecnotPueipFallArelSyd cmtoaonnfauilldfeatnchtteiuadlroebwrunsasittntrehseesasmitnaufrstoerormf'asttihcoeonmvtpaollibuaaenctckhiauniptne,hrpewrhesotuasptepilocnyocomfhpalhiienanidsteamraonglouafftcaisocnstn.ucroeTerhnies. A`acfhoiceuvisngonthpelianctienngdoednotbhjeecmtaivrekse.t would presumably remove many of these issues whilo Intermediates iRnEteArCmeHdiAartteiscltehsat1a7reanudsed18unednearctstrsipcetlcyifciocntprraolvliedsicoonnsdiftoironssub(sStCCa)n.ceSsCCu.sepdrovaissioonn-ssiatpepliysoflattesd etriengcuohmrneoourlsaolgtyieedcsofnaotrraetiurnasenedsdpbotyrotmetidenciihsmnoiilcsaaetleedmmiiensatsenirsomneddaiunardtienasgn,yiwtrsheiswcuhhloilmneugseltixfpbeoecsyucrlrieeg,.oraoTnuhsdelysceocnoptnrrtooavliinsaienoddnsbyparrtoeeccfehudnruitrchaaellr `eqmueiapnmsednutr.insgamtphleinwgh.olaenalliyfseicsy,cleloiandcilnugdianngdmaunnulfoaacdtiunrgeo,fpeuqriufiipcamteinont, ocrlevaensisneglsa,nwdasmtaeinitsepnoasnacle oofr purification and storage. Manuiaciure, use and placing on the market of intermsciates under these sim ckoenydirteiqounisreefmfeencttivoelbyomdeeamnonssithrearteedisinnoArteixcpleo6s8u(r1e),foarnda RheEnAcCeHnroesutrniaccticoen.ptable risk, which is a lIengtiesrlamteidoina,taensdliwhuipcshtarreeamprionpothseedsuipnptlhye crehsatirnictfiroonmCporloudmunct2s, rPeagrualgartaedphb4y,mtoobreenespecfifoicmvearttiicmale umnalrikmeitt,edindetreorgmaetdiioant.eTsoshaovuoliddbienadevxeermtpentteldy frreommovthiengprtohpeosseeddorwenstsrtircteiaonm. products from the Procedent sTuhbestAannnceexs (X2V0.1R2es.t2r0i1c9t)i,onclReaerployrftorfoerseUensdeacnafelxueomrpothieoxnafnooricinatceirdme(dPiaFtHexsA)w,hifcsh swaalstssaunppdorrteleadteidn the final RAC and SEAC opinion (8.12.2021): 9u.sePda,roargirsapuhssed1 aansda 2trsahnasllponrotteadpipsloylattoeadniynotefrmtehde iaftoell,opwirnogv:id(2e)dathsautbtshteacnocendtihattiiosnitnsobe points (a) to ()ofArticle 18(4)of this Regulation aro mat; Product and process orientated research and development (PPORD) `6S7c(i1en)tiffricomreAsnenarecxhXaVnIdIdReevsterliocptmieonnstu(pdeftoinaedqiunanRtEitAyCoHf A1rttiocnl/eye3a(r2,3)PiPsOeRxeDmp(Alretidclien R3(E2A2)C)HofAfretrisclae tRiEmeACliHmitAerdticmleec6h7a(n1i)ssmtattoesactchaetss*(.q.u.)anAtninleesxlXaVrigelrsthahlalnstpheicsiffoyridf etvheelroepsmtreincttiopnursphoasllesn.otHoawpeplvyert,o `perxoedmupctteda.nTdhperoAcesns XonrVierenetpaoxtretd droeesseanrocthcuarnredntdleyvperloovpimdeenat,deasrowegllaat0sailtlohoenwmfaorxPiPmOuRmD,quawnhtiicthy ibsioccriitdiaclalpfroordutchtes,depvleanltoppmroetnetctoifonacptriovdeuscutbsshtuanmcaens adnadrovgeatteerdinianryComelduimcnin2a,lPparrodaugcrtasp.hM4orfoerduestaeilins are provided below. Scope of derogations for active substances The current restriction proposal Column 2, paragraph 4 reads By wayoa.fdaecrtiovgoatsiuobns,tapnacreasgrianbpihosci1daalndpr2odsuhcaltlsnwoitthaipnptlhyotoscopeofRogulation (EU) 528/2012 b1.1a0c7t7i2v0e0s9ubstances in plant protection products within the scopeofRegulation (EC) R.egaucltiavtoiosnub(sEtCa)nNceos7i2n6h/2u0m0a4,n aRengduvleatteiroinna(rEyUm)e2d0i1c9i/na6lapnrdodDuicrtecstiwvieth2in00t1h/o8s3c/oEpCo of Cverrotipciafl eleEgiusrloatpieon.suApproerctentthreevpireowp,osoavlertotheexepemrpitodac1t9iv9e8-s2u0b2s0t,anrceevseaclsovtehraetd60b-y70m%oreofspneceiwfliyc limapuonrcthaendt oprarrteogfisatefraemdmearg'rsoccuhrermeinctaclrsoparperootregcatnioofnlutooorliknite,cMoaminptoauinndinsg.aTnhdesroetactoinmgptohuenldismitfeodrmpoaonl aogfriacgurlotucrhaelmpircoadlucstiwviitthy.dWifhfeernenctonasniddenreinwg mroemdoevsinogfsapcetciiofnicicsokmepyoutondesnstuhrereetihsealswuastyasainabiislktythaotf no atematives are available - depending on the pest control segment. eAcnonneoxmi1cciomntpaaicntss oafdtehteasieledsuabnsatlaynsciessofforthEeuraogpreoannofmaircminigm.poTrhteasneceagrreolneovamnitc fcoormtmheentsosciaor-e Arletloovtahnetroestthriect"ipolnapnrtopproosatle,ctainodn sppreocidfuicctalslyasnedctbiioonciAd.e3s."1s7eAccttoirvsesspuecbisftiaendciensTianblPelaAn.t1PorfotAenctnieoxn Products (PPP), Biocidal Products (BP) and Medicinal Products (MP)of that Annex. Safeners wm Tachteivesusbusbtsatnacnecsewsit(hAirntictlhee 2s(c2)o)p,ebouft Raelgsuolastaifoenne(rEsC)(Ar1t1ic0l7e/22(030)9a)wiatnhdspseycniearlgissttastu(sAratriceleno2t(3o)nbl).y Therefore, the restriction proposal should be amended to accurately reflect the regulation legal text: bR.egaucltaitveiosnub(sEtCa)nc1e1s0,7/s2a0f0e9n.ers or synergists in plant protection products within the scope of TthheersecaorpeetowfoResguuclhatsiaofne(neErC)su1b1s0t7a/n2c0e0s9.whSiacfhenmeerestartehessutbrsutctaunrcaelsdewfhiinicthioanroe fausePdFAtSo,elainmdinawtitehionr rbeeidnugcefipnhalyitzoetdonbiyctehfefEecutrsopofeatnheCpolmamnitspsriootenctDiGonSpAroNdTuEctaonnd cMeermtabienrplSatnattse.sDianatadreedqiuciarteemdewnotrskianrge gsruobuspt.anTchese.oAbjsecwtriivteenis,twoithhaovuet tthheemabvoovteedatmheisndymeenattro, itnhieisateewroeugluldatnoortybreenveiefwsfroofmtthheesefosrpeecsiefeinc dweoruolgdatbieonm,aagnnidfireedqubiryeatlosobeimrpelmicolvyedrefstrroimctitnhgefmraormkeutsewitthheinac1i8ivmeonstuhbss.taFnucretshetrhamtorien,hetrheentilmypraeclty on the safener action for their function. If safeners are not explicitly derogated, the intent of the derogation is thus undermined. Not yet approved active substances oTfheRergeusltraitcitoionn (pErCop)os1a1l07a/s20w0ri9t,teAnsprsouvcihd,esthfiosr adodees.rognaottiocnoovfearcteairvley-ssutbasgteandceevselwoipthmiennttheprsiocropteo sdeuvbemliospsmieonnto,faArtdiocslsei3e(r2f3o)rlfiimristrethviisewt.o W<h1itloen.aTRhesetrqiucatnilointydoofeasctniovteapspulbysttaonscceienrteiqfuiicrreedsfeoarrtcehstainndg aAnndnedxevXeVlorpesmternicttipounrpproospeossaflordoaensenwotacptriovveidseubfosrtaanPcePOtyRpiDcaldleyroegxacteioend,sw1hitcohn.wFouurltdhearlmloorwet,hetshee quaniiies for registration purposes to be manufactured. oTfhteenrebgeistthreatcioansesttrhaattegayppfrorovaacltsivaeresugbrsatnatnecdesindtohiersd ncooutntnreiceess,sparriloyr 1statrhtewiEthUtDheepEeUn,dianngdoint ctahne tEaUr.geAt,sawrEiutreonptehaenrreesgtirsitctriaotniopnrmopaoysanleviserlikbeelyatpoplmiaekdefotrhief tEhUe paesletsosradttirsaecatsiveesloncoattiroenlefovranrtesfoerartchhe aefnfdecdteivveelneospsmoefnatc,tdivueestuobtshtealnicmeista(tiPoanzseonnckavSaieltaball,e2c0h2e0m)i.stries that can be used to maximise the Active substances which are no longer approved tInracnasisteisonasnpaecrtiiovdessiunbsptlaancceefodroeasppnloitcagnetts raenndewMeedmubnedrerSttahetePslaontpPurtottehcetimoenaRseugruleatiniopnlatchee.reTahries i`nmcalxuidmesumaogfroancee pyeerairodfornottheexdciespeodsianlg, ssitxormaogen,thasndforusteheofsaelxeisatinndg dsitsotcrkibsutoifont,heanpdlanitn apdrdoitteicotniona tphriosdluecgtasl cpoosnscibeimletyda(nadrtiaclliegn20accinorRdeignugllayt.ion 1107/2008). The restriction should take into account In principle similar considerations on not-yet-approved and no-longer-approved active substances apply o all active substances in biocidal, plant protection, human and veterinary medicine products. To avoid uncontrolled impacts on 3" countries food and health snyotstoenmlsy,rtehgiesdteerroedgaitnitohnesEhUo.uld apply to active substances intended for such uses, Laboratory use ItplsahcoiungldonbethneotmeadrktheattoRrEuAseCHofAartsiuclbes6t7a(n1c)esitnatsceisentthiafticRersetsreiacrtcihonasnddodneovtealpopplmytenott.hTehmisaneuxfeamcpttuiroen, `tmoaxyicbeolionogarydeaqnuaaltyetifcoal lsatbuodriaetso.riTehsecotnotdaulcttoinnngargoeut(iinnecltuedsitnigngfaors aaccaodmemmeircciraelsesaerrcvhiciencel.ugd.insgucohthaesr g1etnyereaalrcrheesmeiacraclhsaynntdhedseivsewloorkp,metonxticloilmoitg.y, use as a mobile phase modifier, etc.) may exceed the sim Othneeusseuochfeax--aCmFpslemoiisetthye:In Vitro Mammalian Cell Gene Mutation Test (OECD 490), which relies on K`iOnEaCsDe TGeesnteN.o.Mu4t9a0n:tInceVllistrodeMfiacmimenatliinanthCyemlildGineeneKiMnuatsaetieonnzTyemsetsacUtsiivintgy tbheecTahuysmeidoifnae mtruitfaltuioornotThKysm/i-di1n0eT(KT+F-T)a.reThreesiTsKtanprtoftiocitehnet cceyltlosstaatriecseefnfseicttisveoftothTeFTp,yrwihmiicdihnecaaunsaelsogtuhee. pinrhoilbfietriaonteofi cetlhleulparremseetnacbeoolfisTmFTanadndhaflotsrmfuvritshiebrlececolldoinviiessi,onw.hTehruesa,smcuetllasntcocnetlasinairneg tahbeleTKto. enzyme do nol. Anqouitch-ecrhreoxmaamtpolegriastphhye(uHsPeoLfCt)rmiofbliuloerpohaacseaetcimcdod(iTfFieAr)(inLaanradleyutxicHal.ceht ealm,i2s0t2a1r)sy. aAchiidgsh-spuecrhfoarsmaTnFcAe hayrderoapdhdoebidcittoysohfitthtehesupbsHtaonfcetshebemionbgilaenaplhyasesde., aInndtuamsatherreestuelnttitohne tdiemgeraenedofselieocntiizvaittiyoonfatnhde shuabsstpaarntciecsulcahrayndgees,irtahbulse aplrloopweirntgitehseforreliuasbelewdietthecltiiquoind ocfhsrpoecmiafticogsruabpshtayn-cmeasssto sbpeecoiprtoimmeizlerdy.(TLFCA MFSor)rdeegtuelcattieodn ssyesctteomrss,isbteecdauinseCoitlisummnor2e, vPolaartailgeratphahn4al(tbeiorcaiidavle,spalnandtdporeostencottiofnoualntdhehiuonmasonuracned. vreegtiesrtirnaatriyonsm.edTihceinsael apnraoldyutcitcsa)l, meatnahloydiscaalremelteghaoldlys rmequusitredb,e asnpdeciufsieedd faosr pprarotducoft cthoemplpiraondcuec,t minectlhudoidngrecqouimrpelsiadnecveeloofpmiemnptoritnead lfaoboodrawtiotrhy tMoadxeimomnusmtrRaetseitdhuaet itLweovreklss, (fMoRlLl)o.wedAbycahannguepdtaotethoef the respective registrations before it can be used. CursoepTLFfeAEausropapretdoofetsheniortdceusrcriepnttliyonh.avHeowaenovevr,eermpvioriifcetahlwleyntuimbcelreoafr mtheatthoadns1i8m-pamcotnetdh,ti.r.a.nwshitiicohn apuetrhioorditiisesinfsourffaipcpireonvtalto, adnedveflionapllnyerwolemeotuhtotdosg,ovreegrinstmeerntthaensde iwnidtuhsttrhyetreeslteivnagnltabcoormapteortieenst. Gbievemnodtihfeiaedbotvoeienxcalmupdleeasl,l alanbdomraatnoyrymourseescainndbeepaenntdiceinptatoefd,rCesoelaurmcnh 2a,nPdadreavgerlaophpm5e(n1)t, ssthaotuuls.d 2. Hazard Characterization = Addiional information is provided on biodegradation of PFAS substances which are not persistent, and specified as outof scopeof the resriction proposal, Biodegradation of PFAS substances Tdehfeinisttiaornt,inwghipcohintisftorhetnhenasrcroopweedofstlihgeht"yuntioveprlsaacleTM-oPuFtAoSfrsesctorpicetisopnecpirfoipcocsaolmpios utnhdesOwEhCiDchPcFarArSy isei.ngclean-nCotFboer CcoFn.sidgerroeudps"fwohriecvhericnhtehmeimcsaellsv".esAlhtahvoeugnhotmbeeeetninagsstohceiaOtEedCDwitPhFeAxStrdeemfienipteirosn,isttheenscee ifnusntcatbiiolntaylugnrdoeurpsecnavninroontmbeentaclolnysirdeelreevadnttobcoend"iatrironosw.head" substances, becaouftsheier fundamental `PTahpeebra#si3s54f6or1 iadveanitliafbylienginthAensneesxpe4cific functional groups is provided in CropLife Europe Position tItihs e aebssoevnetitahleotroerteiaclailzwe othraitkthceosrreecetx.peArsimsuecnht,satrheegpnrleyciisnetedndeetd atooifptlrhoseveetxhpeefruinmdeanmteanltcaolnbdaistiisonfso.r vuasreydwihtehreeadcoh nmootlemcautlteewrh(iec.gh.,co2n0taCinvsso1n2eoCf).tThheisseifsunbcetciaonuaslegtrhoeuposbs(ee.rgv.edOCdeFg)r,adadteipoenndriatnegwoin the broader chemical structure of the larger parent molecule. The essential and key point s that the wihdeincthifmieadyfubnectriegoinsatlergerdouunpdser(sRuEchACaHs,-aOnCdF)hednocenotthecroenfisernopebrassiisstfeonrcaenona apriloarrigberanmoolnecsuulceh oz `rmeoslpeeccutlievse.dMososlieecrusl.es registered under REACH must still demonstrate lack of persistence in their `The parent molecule for the below experiments (benzoic acid) was chosen with the expectation that sittwaonudladrdbiOoEdeCgDradgeuirdaepliidnley,etxhpuesriamlelnowtianlg coobnsdeirtviaotnisono(2f0thCevfs a1o2fttC)heecOhoCsFe;n mwoeireety.toSiemnisluarrley,tthhaet sufficient degradation occurs to identity metabolos and haltives with minimal uncertainty. cRoenctaelxctuliastniootn atoRE1A2CCH irsegciosntrsaitdieorneddosssuifefricfioerntalyspaecccifuircatseubsfotrantchee,sebupturraptohseerst,heapnd rboefcoacuoonsceafptth.e sPurpeplliimeidnatroyEdCatHaAon(RbAiCo)deignrCardoatpiLofnoinEusoriolpoef B*r*iCa-fTirngifNloutoero#m3et5h9o7x3y ibneAnznonicoa3c.idAnhauspdbaeteenipsrpervoivoiudseldy ainttCahcahepdtteo3rthoifstdhioscduomceunmteinntAn(Snpeexcif2.ic Information Requests, Question 9), and a study summary is aPslapcrionpgotsheedspbeycitfhiecDaolslsyiiedrenStiufbimeidtftuenrcst,idoonaelsgnrootuipnsanouytwoafyslcoowpeeropfrtohteectrieosntroifcthiuonmaprnophoesaallt,h otrhethleaceknvoifrpoenrmseinstte,nbcee,caIuncsleuidtirnegmaaniynsmeitnacbuomlibteenst,Ionn tahneyrReEspAeCctHivreogRisEtArCanHtsrteogidsetrmaotnisotnsr.ate Tonnage and emissions ~ molecular weight correction Page 72ofthe Annex XV makes reference to a list of active substances in PPP in Appendix A.3.17 d(epfaignieti2o7n,2)Waendwiisnhcltuodneostea trhoautghheesvtaismtamtaejotrhiatty2o%f aocfitvoetasluEbUstsaanlceesosfcosnutbasintaonnclyessimnegleetftlhueoriPnFatAeSd `ovmeoriaeltliesma(is.es. -oCfF2t-hoers-uCbFs3t)a,nacneditnhiqsu"epsetrifolnu.crTinhaetedreamlkayilnmdoeiretoyf" tihsethmuosloencluylea scmaanllifnrancotiownaoyf tbhee cisoncsoirrdeecrteeddtfoorb,e PFAS --the results a clear overestimation of PFAS emissions by mass unless this T41heplraensttrpioctlieocnipiroonpaocstailveApspuebnsdtiaxncAe,sAapnpdensdaifxenAer3s1b7elpireovveiddteosmaesett tohfecOliEvCeDsuPbsFtAaSncdeesf,inFirioonmatnhed. icunrfroernmtaltyiona:pproved to be placed on the EU market, CLE has derived the following average Table 1. EU approved active substance & safenors n=41 [Wm| Waar Average Wilscuar weight range (gimal) [m2 [ema [ama %(69PgFiAmSo)momioeiteytimoasstsha-t bmaeseetdthoenOCEFC2D(5P0FgA/Smolde)fiannitdioCnF.3' APsFAaSre"saurltr,owshienagd"tsheubAsntnanecxe XwVereesttoibmaetfeoorfm2ed% wciotnhtrniobudtieognr,adaantdioan,sstuhmeinntghethaectwuoarlstmacsasse-btahsateda emissions would be 0.4% (i.e., 20%ofthe current estimate). T"PoFaAvSoiedquoivvearleesnttitmoantniaongeas'ndfodriascttoirvteiosnubofstraenpcoersteidn PtoPnPnaagneds,saCfeLnEersstrwohnegrlye trheecmoomimaetyndosf iuntseereosft forms only a 4,ii) should minor part of be modified ttoheremqoulierceutlhe.erAesposrutcihngtheofr"esPtFriAcStieoqnupirvoapleonsta"l qCuoanltuimtines2., Paragraph `Specific comments on Annex XV report Atensntreixcti5oncpornotpaoisnaslsipnecAinfnicexcoB.mments on the interpretation of toxicology studies reported in the. un 3. Specific Information Requests cFoonrsuelatsaetioofncSrpoescsifriecfeIrnefnocrimnagt,iotnheRenquumebsetrsi.ng in this section follows the questions i the public 1: Sectors and (sub-)uses: aPlnedas(esusbp-eJcuisfoystihdeesnetcitfoiriesndanthde(Asnubn-oJxusXesVtroawshtirccthoynourrepcorotm(mTeanbtloap9)p.liIefsyaocucrocrodimnmge(n0tthaeppselcetsortso soveral soctors and (sub)uses, please make sureto speciyal o thom. "The following four uses have not been covered in the AnneXxV restriction proposal Fluorinated packaging in regulated sectors Finlvuoolrvienaatgegdrpeascskiavegionrggainsirceqsuoilrveednttso,ianenrdt pmliagsrtaitcipoancokfagtihneg,soplavretnitcutlharrloyugwhhetrhee tphlaestciocntwenatlss. WAonunledxpXoVseraepsoratf,etTyahbalzear9d.,TThheesree cisonmomecnletasr aalrleocraetlieovnafnotrathsisausmein[0imausmecttoorthsepefcoilfoiwedinign csehcetmoircsaslpeicnidfuisetdryi.n FTuarbtlheerA.i1nfoofrmAantinoenxfoAr:thpilsaunstepirsoptreocvtiidoendpurnoddeurcQtusesatnidonbi6o.cides, and Intermediates IalnltoecramteidoinaftoerstiinsucsheemtiocaaslecsytnotrhesspiescifhiaevdeinnoAt bnoeXnnVexerpelpicoxirttl,yTdaebrloega9t,eTdh.eTsheecroemimsennotsclaeraer rperloetveacnttioans paromdiuncitmsuamndtobtiohceidfeosl,loawnindgcsheecmtiocrsalspiencdiufsiterdy.inFuTratbhleer AinfforomfaAtimonefxo At:ispluasnet is provided under Question 6. Laboratory use Tinhaedegqeunaetrealfoer xleambportaitoonriefosr croensdeuacrtcihngarnodutdineevetlesotpimngenats farcoommmReErcAiCaHl sreersvtirciecti(o5n6s8miayvibteo daisaegcntoosrtiscpsecdiifscludsisnioAnnninemxiXcrVoprleapsotrit,c Treasbtlriect8i.onA)s. T@hmeirneiimsunmo,dtehaersealcloomcamteinontsforartehirseulesveantto b10iotchiedefso,llaonwdincghseemcitcoarls sipnedcuisftireyd.iFnurTtahbelreiAn.f1oromfatAinonneoxrAt:ispluasnetipsrpootveicdteiodnupndreorduQcutesstainodn 6. Uses in Production Equipment foUsrtehsisiunsperodtouactsieocnteoqrusippemciefnitedhaivneAnotnbeXneVnreeexppolixrcti,tlTyadbelreog9.aAtesd.a mTihneiremiusmn,otcheesaercaolmlomceantitosn aprreodruecltevsanatntdo tbhieocfidoelsl,owianngdsecchteomrsicsapleciifnideudstirnyT.abSlterinAg.e1ntofsaAfnentye,x iAn:tepgrliatnyt apnrdoteqcutailotny sTthaensdearsdtsanadnadrdrseaqunidrreemqeunitrsehmeanvtesbceaennofitmepnoosneldy ibnetrheeacEhUe'ds bmyodreelryningproonduPcFtiAoSn msaytsetreimasl.s cteoclhunmolnogiynt.ernItalssh,oluilndingtsh,erfeifeorrse, mbeemnborasnuerspr,isdeiatphhartatghmes,maejloercittryonoifcsv,alevtce,s,usgeadskientsi,ndupsitpreisa,l stheatttinmgesectontthaeinsaPmFeASstbrainsgeedntmastaefreitaylsa.nTdheinctegoritmy sptalondfeadrexdvseilaostpiwyneglaansd freespltancginagltPemFaAtiSveisn production equipment wil nolusbt technologically complex and extremely expensive, i wil aAlsdoettaialkeeddseoccaidoe-secwointohmiocnlayslsiemistsemdepnrtobwialbliblteypfroorvsiduecdcebsysC(EaFvaIiClarbeilptryesoefnrtiuneg atlhteemcahteimviecsa).l on industry, and additional information is not provided here as a consequence. As CLE we. psruopvpiosritonathraetqwuheistchfoirlaacktiimneg-iunnltihmeictuerdrednetropgraotpiosoanl.for PFAS in production equipment; a 2: Emissions in the end-of-life phase: pThhaese.envTiorognomtenatabletitmepraucntdearsssteasnsdmienngtofdotehse enxottonctovoefrtheemirsessiuolntisngreusnudletriengstfimraotmiotnh,e (esndu-bo-fJ-ulsiof-e `ispee.citfhiecimnafnorumfaatcitonureiprheasqeu,esthteoeundseempihsassioenasnadcrtohsesetnhde-odfi-ffiefreenpthasstaeg.ePsolfetahseeprliofveicdyceljeousftpirfiocdautcitosn,s for the representativenessofthe provided information. In particular: a) Please provide, at the (sub-Juse level, an indication of the share of emissions (as pveorlcuemnetsaginest)heatetnrdi-bouft-albilfee ptohatsheesaetstehcrteoerodirfesruebn-tsescttaogerls.eveAlnwionudlicdatailosno obfeaanpnpuraecliaetmeids.sion b) Ifpossible, please provide for each (sub-Juse what shareof the waste (as percentages) is treated through incineration, landiiling and recycling. Please provide information tojustify the estimates as wella information on the formofrecycling referred to. No informationiscurrentlyavailabletoCLEforthisquestion. 3: Emissions in the end-of-Ife phase: oWfitihncriensepreacttiotno wuansdteermnaonramgaelmoepnetraotpitoinoanls,caondddiittioonnasl i(nfofrordmiaftfieornenits rwaesqtueestytpoeesnd, teh.e.efhfaecztairvdeonuess,s municipal) with respect o the destruction of PFAS and the proventionofPFAS emissions. _-- -- 4: Impacts on the recycling industry: iTnofogremtatiaonn uisndreerqsuteasntdeidnogn:of the impacts of the proposed restriction on the recycling industry, a) The impacts that the concentration mits proposed in paragraph 2ofthe proposed restriction ehnatvteyotenxtth(esoteecthanbilcealstaanrtdinegcoonnopmaigcefe4aosifbtilhietyosfuremcycmliaonfgrtphryeocAensnseesxX(tVogreetsthreircwtiitohn arecploreta)r b) iTnhdeicmaetiaosnuornesthtehawtarsetcyecslterrsewaomusltdo nweheidchothteakdeestcoraicbheideviemptahcetpsrolpaotes)e.dconcentration mits. ) The costs associated with these measures. No informationis currentlyavailabletoCLE forthisquestion. 5: Proposed deroga~tTiononnagse and emissions: Psaurmamgarrapyhsof5thaendAn6neoxf tXhVe prersotpriocsteiodn rreesptroirctt)ioinncelnutdrey steexvter(asleeprtoapbloesesdtadretirnoggaotniopnsa.geFo4r otfhetshee prersouplotisnegdedmeirsosgiaotniosnst,o tihnefoernmvaitiroonnmiesnrteqfouresttheedroenlevtahnettuosne.naPgleoeafsPeFpAroSviduesejdusptiefricyateiaornsafnodr tthhee. reprosontativenessof the provided information. No informationiscurrentlyavailabletoCLE forthisquestion. 6: Missing uses -- Analysis of alternatives and socio-economic analysis: hSievgehrlailghPtFieAndSbluuseaesndhoarvaenngoet ibneTeanblceoAv.e1roefd AinnndeetxaiAloifn tthheeAAnnnneexxXVXVresrtersitcrtiicotinornerpeoprotr.tIn(saeddeituisoens, oz rseoqmueestreeldeovanntaltuesmeastimveasyannodtsohcaivoe-ebceoennomiidceinmtipfaicetds,yetc.oveFroirngsuthcehfuoslleosw,insgpeecliefmiecntisn:formation is a. uTsheo. annual tonnage and emissions (at subvscclor eve) and type of PFAS associated with the relevant b... TThhookneuymbfeurnocfticoonmaplasniporsoinvithdobesydecPtForASefsotrimathtedroolbevoanatfuosecibeyd tho rstriction. 4. iTnhcoluadvianiglaibnifltoyr,matteicohnniocnaltahondexetcaonnto(miinctefremassioiflym,arhkaeztarsdhsarasn)d sfokwshiocfhaoarlmoamtaitvievse-fobrastheedrperloedvuacnttsuasre,o eaxlpooacdtyedaferod on the EU market and whether any shortages in the supply of relevant atermalives are o. sFaobrlecaiaenmsawihaiivcsehsa,lineclmudaintgatrihoooneosxttyeantt aovfaRiEabDlei,aiivnes fin toeonrtmhsreosftmmateusaoafnRdtoErDipnraonocceislsnainsvoerstfmienndtisn,g hreelelviaknetlichoorotdioifcasiuocnceosrsfrueqlucioamtpoortyiaopnp,rotvhaelst)imaendextpheectmeadjo0r bceharlelqeunigraesdefnorcosuubnstteirteutdiownil(hclautdeimnagtiavneys Fwohricchawsearsoicnonwshiidcehresudbbstuitsutuibosnoiqsuetencthynidciaslrleygaarnddede.conomical feasible but more tm is required fo s11u.bstitthuete:typo and magnitude of cost (a company lovl and, favailabe, a sector level) associated with 2. sthuebstiimieforneq(ue.igr.edcosftors fcoormpolewtoiqnguitphmeosnutbostritcuhtaionngopsroincoepsesra(tiincnlgudcionstgs)a:ny relevant certifcation or 3. riegnulfatoorrymaopnaprptoovsiasloisc;ne fereinnfuncctioenalsity and the consequencesfordownstreamusersand ccoonnssuummpetrison(.e.g., estimations of expected early replacement needs or expected additional energy 4. 1F.o4.r ciasnefsoinrwmhaiotcnhitsohunobsbtotnueinssfonoattotneachtniivceaplrlyovoirdeercso.nomically feasible, information on whl the socio percoovniodmeitchoimapnancutasl wvaoluulodobfeEfUosacloemspaannidspsr,ofciotnosfutmehresr,leavnadntofshacotrora,fafencdteedmapcltoorys.mefntavnauimabbelr,spolreatshee Soctor. 6.1: Fluorinated packaging in regulated sectors Fluorination in a chemical packaging context is a surface treatment technology required to ipnaerrtticuoltahrelrywwihseere"ftlhueoriinnteenfdreeed"chpleamsitciaclpcaocnktaegntisnginv(osluvcehagghraessshiigvhe-odregnasniitcy spoollvyeenttsh,ylaennde m(iHgrDaPtEi)o,n of the solvent through the plastic walls would pose a safety hazard. Use of such packaging is required to meet the requirements for Transport of Dangerous Goods (TDG). Furthermore, such packaging forms part of the formal registration requirements of the pRreosdtruiccttsi,onhuprmoapnosaanldCvoeltuemrinna2,ryPamerdaigcrianpahl 4prdoedruocgtsa.teTdhesescetovrerstii.cea.lblieogciisdlaaltipornosdupcltasc,epsliagnntifpircoatnetcctoiosnt ahanvdetibmeeencondsetvrealionptesdo.nTthheersepeisednoatcwlheiacrhalallolceamtaitoinvefsorcatnhibseussuebsttoitautsede,ctifoarvasipleacbilfei,eodr ianfeArnntehxe.y XV report, Table 9. A`sA: palmaintnipmruomt,ectthieosnepcroomdmuecnttssaanrdebrioeclideevst,aoctnhhteemfioclallowiinndgussetcrtyo,rsanspdecoitfhieerd`iUn sTeasbluenAk.n1oowfnA'nsnuecxh as "chemical laboratories". iDmeptaacltedcliemaprlayctapipnlfoersmattoiomnahnays ootnhleyr bseecetnorpsropvaicdkeadgifnorg thhaezaplradnotusproctheecmtiicoanlsp,rodauncdt isnecptaorrt.icTulhaer otrragnasniitciosnoltvoenatlst,erninatpilvaestpiaccbkoatglliens.g mAatedreiraolgsa.tion is requested to allow sufficient time for oz 6.1.8: Annual tonnage and emissions pesticidIendpuasctkrayglienagdwCiothnitnaiEnUe2r7Maconuangtreimees.ntThSeystatregmest c(oClMleSc)tihonavreatebefoernmiantturroeduscyesdtteomcsolilse6ct6%usfeodr E(aUim2s7t(o202i1n,clauidmeianlgl f2o7rm7e5m%bbeyr2s0t2a5t)e,sabnyd22020o5)f.27 countries are managed by industry driven CMS O"vTehreaallv,ertahgeecqolluectaioonnfrpaeitsetiiisciaydpeprpoaxcikmaagtienlgy 6pl6ac%edinonEUt2he7-mcaoruknettr(esE(2U022o1,r7tlha)teespteraivaoidl2ab0l1e8-da2t0a2)0. irsigaidppprloaxsitimcatpealcyka3g3i1n0g0.t Tphlaisstircep(wrietshenatnsu2nc3e2rt0aoifntfyluo1r7i%n)a.teOdfptlhaissti7c%paics keasgfiinmgat(ebduttotbhies filsnuooritntatheed quailty potential considered PEAS). Proportionofdifferent material types placed on the EU27 market mFiagrukreet1.SoPurorpcoerftoiontbiyspedracteanatrweeiagnhntuoalftCotMalSshrieppporetdspglaesnteircaptaecdkabgyinCgropplaLcfeed oEunrhopee.EUTZh7e eWistthim5atreodspproonpdoornttiosnoifndilcuactrinngatuesdapoafckfalugoirnignfastetdhepraecskualgiongfa.sAurvveeryaogfe fomretmhebeprercioomdp2a0ni1e8s, 2020 used. T10h.ea avemroyunthtinofbaprortieenrtiaaylelyr.PFThAeS paoctteunatlilayllcyonPtFaiAnSedsuibsatpalnacsetiscfcoornmtaeidnedrepisevnedrsyosmnaltlh,eapnladstiisclibmeiitnegd terxepaetcedt.edFtoorpprloadnutceprpootelcyttieotnrafplruoodruocettshylwehneer(PTtFhE)btohtatll,e wpiltahstaicsuifsficHiOenPtE,defglruoeroinfaftliuoonricnoautlidonboef the surface carbon chains, would then meet the PFAS definition (KharftonAo.v P. et al, 2008). pThlearsemaarfelutohrrienaetmioani,namnedtphoosdtsuoorficnraetatiionng.aTfhleuolraitntaetretdrbeaartrsiearllosnurafapclaesstoifc bthoetb:otlnl-em(oilndsildueoarinndatoiuotn),. while thefisttwo methods use fluorinated gas to treat only the insideofthe bottle. g`Caosmdmuornilnyg utsheedexitnrEuusrioonpeblIsowinm-omallddinfgluoprrioncateisosn.tIonf-omromldtfhleuobriantateionntaopptlhieesmotlhed.flTuohreinterceoanttmaeinntinigs thheartsaflosroeocnrleaytoens athbearirniseirdeonolfytohenbtohttelie.nsPildaesomfatrhleuocornitnaaitnoenriwsitahpsriomcielasrsbsatrerpienrtphreopebortttileesptrooidnuc-tmioolnd mfloulordiendatfioonr. mPeosdtfblotuiolrei(niantsiiodneof&opuatcskidaeg)iwnigllsbea rsaeptaerdataefperrotcheesesxtsrtuespiwonhebrleowthmeolsduirnfga.cTeohfetqhueanftuiltlyy of PAS depends to some extent on the technology used to generate the thin flurinated barrier layonethre bottle surface, but are expected toberoughly similar. win Estimated possible PFAS tonnage calculation The thickness of a fluorinated layer is estimated to vary between 0.1 and 10 um. For modem layer consists of PTFE. Massofpotential PFAS in packaging = thickofnbearsriesr layer * total surface areaof packaging * Table 2. (m?) fon the market (m?) layer PTFE (kg) to 380 (LXWxH) [0.494 [1250000 617500 (0.06175 YO Gc 0 bottles or canisters with a volume of 1L, 5L, 10L and 20L which represent 89% of the rigid plastic to reflect any special shapes of round bottles and rectangular canisters. The number of bottles for each size is calculated from the total tonnage placed on the market (23201), the proportion contributed by the market share of the respective bottle size and average mass (see CLE CMS- data). The barrier layer is assumed to be PTFE with a densityof2000 kg/m? (2 glom?). AAA Not considered in this calculation are bulk packaging, such as drums or IBC's, because the majority of packaging used is covered by the four small sizes. Assuming this represents approximately an placed on the market for crop protection products is approximately 663 kg/year. in the 20 Members States with a CMS, and up to 84% in some Member States). 7countries do not recovery, because there are other unmonitored local systems in place that operate collections schemes. We aim at ensuring collection programs are available in all EU MS by 2025 with an Wsihtrheidndintgh,e aCnMdS,extprruidmianrgyopplealslteicts.paAcnkyagpiancgkacgoinntgainnoetrssuairtaeblceofnosidreecryecdlifnogr irsesceynctlifngo binyciwnaesrahtiinogn,. oAnsstuhmeinmgartkheetreilea.tiv7e%p,rotphoretnioanpopfrofxliuomraitnealtyed3p9a4ckUaygeianrg soefntfltuooriinncaitneedrartiigoind ipsatchkeasgainmge awsouplldacbede ionrcianserraetfeud.se Idnecriinveerdatfiuoenlo(fRtDhFe)cfoolrlehcitgehd-tpeamcpkeargaitnugreoccceumresnvtiakimlnusn.icCirpoaplLwfaesEtuerionpceinderoaetsionnotplahnatvse,. aInnypriinncfioprlmea,titohneopnacpkoasgsiibnlgecPolFlAeScteedmivsisaieosntsarbelsiuslhteidngCrMoSm fiornpecstiicnideeorfpapacakctakgiaignoig,nngdoweasstneotsternedamus.p in landiil 6.1.6: Key functionalities provided by PFAS and thoFslueorhiannatdiionnigsupsroedducatssaablaornrgierthteescuphplny tocohlpairono,tgeecyltc.t)hebeynvmiarinotnamiennitngantdheusperesrf(ocrumsatonmceerso,f dplaansgtiecroboutstlgeowohdischcetrthieficeodntpeancktasgianrge.inItccornetaatcetswiathf.luTohriisnatteedchpnoilqyumeearvolaiydesriosnsutehsessuucrhfaacse sotfrtehses ocfradcaknignegrwohuischgocoadnsirmepgaucltattihoensp.erformance of the packaging required for compliance with transport Tfuhnectiboarnriiserusiusavlleyrytoofctreenatbeuta nboatrrieexrclaugsaiivneslty puesremdeaftoirosnoolrvemnitg-rbaatsieodn offortmhuelaptrioondsu.ctTchoomproenqeunitrsed. a(el.sgo.,besoluvseentd,aasctainveosxuybgsetnanbcaer,rieertct)o tkhereopugfohrmtuhleatpliaosntipcrobpotetrlteiewsalwli.thiFnurtthheerrmegoirset,ertehde pbuarrirtiyermictasn over the regulatory requirement for two-year shelfife. SthuerfuasceedfuluroirnignattheedrHeDcyPcEincgonptraoicneesrss,aurnelickoenostihdeerrebdararsierremcaytcelarbilael,sa(nHdDtPhEis/dEoVeOsHnootr iHmOpPaEctIoPrAlicmoi-t extruded), thus reducing waste streams. sSceieentiTfirce.sseaxupldaneattialon(2o0f07t)hein tpeacrhtniiccuallar psreocpteirotnies"3.i2n.2t.r1o.duBcaerdriebry psrouprefratciees"flufoorrinaatmioonreofdeptlaaislteidc packaging. Kharitonov A. P. et a (2005) provide example chemistry details of the surface treatment process. 6.1.: Number of companies in the sector fluorinaItnedgepnaecrkala,gianlgl cfoormpsapneciiefsicpprroodduuccitngtyppeestsicdiudees,foanredguclhaetmoircyalrecquoimrpeamneinetss itno gceonmerpally, wuisteh tprraondsupcotrsteo.fg,d,asntgoerragoeusstgaboioldtsy., cIannaldedaidtotno,threegniesterdattioonusreeqfuliuorreimneantteds piamcpkoasgeidng,ondeppleanntdipnrgotoencttihoen types of product manufactured by a given company. 6.1.4: Availablity of altematives. creatingToaoubrarkrineorwlweitdhgoeutantdheasoufsetodofayftlhueorrieneargeansoesaltienmatthievemsarakveatil.abHloewfoervears,urtfhaecree tarreeatomtehnetr tienscihdneolaongdietshebasseecodnadropuronvdidcion-gexsttrruucstiuornalofsutpwpoorptl.asEtxicamtpylpeess taovafiolrambltehaenbdotctulre,rewnittlhy oonnethleinmiangrktehte arrapeidHOtrPaEns/itPiAon.or HDPE/EVOH co-extruded packaging, however, there are significant hurdles to a a`Tnhde acusryrmemnettcroinctacionnetraisnherapsehuaspe-edbiystdehseigmnajeodriftoyr hofantdhienpgesptuircipdoesepsr.odTuhciserdses--igandea-vociednsteerxepdosnuercek ohotphpeer.pesticide and contamination during emptying the packaging into the spray tank or induction 13123 (WiPtAh ocro-EexVtOrHud)edismantoelricaolnssissutcehntalsy HevDePnE/fPorAaonr HaOsyPmEm/eEtVrOiHc,botthleledidsetrsiibguntioannodf tchaenbairnrfireirngleayoenr ruseiqnugirceomeexnttrsudfeord amamteirniiamlu,ma wnalelwtbhoitctklenedsessitgonhwaovueldanneefefdicteontbeanindtreoffdeuccteidvebybatrhreimerajloaryietry.oWfhethne apedsatpitcaitdieonsp)r,odtuecsetrisn,g FfuorrthUeNrmotrrea,nspaodratplaoftiodnasngoeropursodugcoiondgspacecrktafgiciantgion(,neawndtooplrsodaunctdiodnesifignne modifications would be required. Trehgeistpraatcikoan,gisntgudifeosr opnestthiecisdueistabisiltspoefcipfaicekdagiinngaarpelarnetqupirroetdec(t2ioynearpsrosdtuocrtagreegsitsabtirlaittiyo)n..AFcohrantghee tpoerafnoramletdemaatnidveprboavrirideerdtaeschannoluopgdyatreepltoactihneg psruordfuaccte frelguirsitnraattiioonn.wAouclhdanregqeuitroetnheewpasctkuadigeisng(0cbaen. only occur after approval by the respective competent auhriies. Ointdhuesrtrpya.cTkhaegisngamfatoeefretinaylds ussuecrhsahsasgbleeonarimnsectrseaalsehdavseinbcoeetnhehsihsitfotriocalilgyiduspeldastbiyctphreimcarroyppparcotkeacgtiinogn --rbeqoutihrewditwhaasndhiwgihterh,ourtelquuoirriendatmioonr.eThcueshriisoknoifnglamsalserbioatli,eabnrdeaikmapgaec,tpeadritchuelatrrlaynsinpotrhtealnardgesuspipzleys icnhnaeirnctohartoiungghs,ioncrweaassemdowreeigehats.ilMyetdaalmpaagcekdag(ibnygpwuancstulresisngr)esdiusrtianngt ltoogciosrtircossihoann,drienqgu.ired additional iTnhecusrerepnrtevpirooudsulcyturseegdismtaratteiroinasl,soarrearneoteacsolnysidavearieldabalse piontetnhteiaplalyckaalglionwgabliendausttermy,atainvde pcaacnknaogtibnge considered viable (ransport weight), aelttc.ernatives due to the significant reduction in safety, carbon dioxide emissions aItsshcoou-ledxtbreudneodteHdOthPaEt/poEtVenOtHialoratHePrEaiIvPeAp)achkaavgeinlgimtiteacthinoonloogniersecuyscelaobtihletry baanrrdietrhmuasteproitaelnst(isaulclhy increase waste streams. a`Schroorstsagoetsheornirndauwsimraytesreicatlosrsfo(ropoadc,kaofg,incgheamriestnroyt,ceutrcr)e,ntalryekcnoonwsni,debruetdwiathlikaenlyercisokn. oSmhyorwtiadgeesshoifnt fmoartebortiiallessoarnidndcuasntirsytecraspaacrietcieosnstihdaetraerdetaobvaeivlaebrlyelfiokeclhy.anLgeea,d-uipgmreasdfeorornebwulmdolndeswfporropdluascttiicobnottololless hreatvuernaeldretaod_ypbroe-epnanodbesmeircv_eddu1r0atiinocnrse.asSeimdiuleartoitnhcereraesceesntinCOlVoIaDd--1im9epsanrdeeqmuiirce,dafnodr hcahvaengnoetsyetto pfreotduumcetdiotnoehqisutioprimceanltnoinrmlsi.ng and packing production lines have also been observed, and not yet aAsbaotntliemmneedcikatcoeubladnbweitthhae aduetrhoograittiieosnfpor ere-rorefg1iis8trmoaotinodtnhoronulpydwaitlelseoafd etxoiasthiunggepraomdouucnttreogfirsetqruaetsitosn.s ina short timeframe. 6.1.: Future development of atematives creatingToa btahreribeerstwiotfhoouutrtkhneowulseedogfefltuhoerrieneargeasneosalntetrhneatmiavrekseta.vailable or a surface treatment Tadheeqrueamtealyy btoe mceerettaitnrapnrsopdourcttosffdoar nwgheircohucsurgroeondts,atoermaptlainvtepboalrercieiriomnatperroidaulcstdsoonroatgpeesrtfaobrilmity requirements. 6.1. Information on substitution requiring additonal ine: 6.1.1: Costs cNuorreesnttilymaatveaiolfabcloestbsut(0afruelloybivmipoluselmyenvteraycsuhbasntagnetitaol,alternative barrier material bottles is wiz AMnemabpeprropSrtiaatteepdlearnotgpartoitoenctpieorniopdrowdouucltdraelgluolwaftoorrs,aamnadnraegdeudcetirnavnseisttimonenbtynbeoetdheidnfdousrtrpyeaakn.d resource needs (`latening the curve'). 6.1.42: Time te.i5s. ecsatpiacmiattyedcotnhsattraatinltesasint s6tyoeraagresswtoaubilldtybetesrteiqnugirleadbofroartotrriaenssi,toiornraessosuurmciencgonnstoradienltasysb.y caphparnogveisngtorepglualnattporroyteauctthioorniipireosduccotnsriedgeirstirnagtitohnes.anticipated large number of application for EEE Figure 2. Timeline for substitution of fluorinated packaging specific to the plant protection product sector under Regulation (EU) 1107/2009. mWahjeornituyosifntghceoepexstiriucdiedde pmraotdeurciearls,,aFunretwhebromtotlree,deasdiagpntawtoiuolndsntoeepdrotdoubcienignptarocdkuacgeidngby(ntehwe. ttoiomles(aunpdtdoe2s4igmnonatdhasp)t.ations) and production fine modifications would require additional AfatnedrUaNn attreanmsaptoirvteopfadcaknaggeirnoguhsasgoboedesn fteosutnindg)(.intchleudriengiscoamplaetgiablilnieteydtetsotipnrgobviydaeneavpaplluiactainntg, MsteambibietyraSttaatmebiaeuntthortielmepserwaittuhret,heorrebsyultesxtorfapsotloartaigone swittahbialcycetlesetrsa.teEditshetror2a-gyeeasrtusdtioersag(e2 awceceekpstaatnc5e4ofCexatnrdalpoorl2atmioonntbhys aautth4o0riCt)i.esCrisopvLairfiaebEleuraonpde dmeepmebnedrssoenxptehreifeonrcmeulsahtoiowns ttyhpaet. `2a7ndfmoartsetraibailltuyseadn.dD4a.1t,a4r.e4qufiorretmreannstpsoratr)o.al listed in Regulation (EC) 28412013 (see sections. FHienralelyt,hetitmiemeilsinreeqiusiareldsofovratrhiaeblaectdueapleenvdailnugatoinonMbeymtbheerMSetmatbees'rcSatpaatceitcioemspteotepnrtocaeustshorpliatnyt.. pPrFoAteSctoironotphreorduCchtesmidcoaslsiSetrrsatreeggyulfaotrorSyusatcatiinoanbi(lctuyrrienntdluyce6dtdoe1m2anmdosn)t.hSseweitthhenoDGaddSiAtNioTnEa.l report of Member States timelines for products actions (EC, 2020). cCoonmspildeetreilnygintshueffaicbioevnet,atnhde wdoeufaludltreRseuslttriicntiloonssproofpaotsalleaosftasnom18e-mploanntthptrroatnescittiioonn ppreordiuocdtsi.s wAhgircohnomariec lroesqsuiersedandbyecroenguolmaitcionimptoactbse opnafcakramgeerds ainndsptehceiffioeodd fsluupoprliynatcehdainpaccokualgdinbge.. apnltainctippartoetde.cCtoinosneqpureondtulcyt, saedcetrorogiastrieoqnuefsotrefdl,uaornidnamtoerdepgaecnkearaglilnyginustheedbirnotahdeerrecghuelmaitceadl sdeecrtoograthiaonndpienrgiohdawzoaurlddouasllsouwbsfotranacmeas nuangdeerd ttrraannssiptoirotnobfydbaontgherionudusstgroyodasn.d AMneampbperorprSitaattee plant protection product regulators, minimising peak resource needs (fattening the curve'). 15123 6.1.0.3: Differences in functionality TlahregreerispacakraigsikntghastiazleslewmaittihveabnarirmiperascttooPnFtAraSnsdpoorntotofpdearnfgoermroaussegxopoedctsedtr,anisnpcolrutdianngdfor product registrabilty. For some chemicals it s ikely that alternative barrier materials wil require a greater apancdkiangcirnegaswaeldlwtehiigchktnepsesr tbootatlceh.ieTvheisthceousladmheavbearriimepracprtospeorntiseuss,tatihnuasbiulstiynggomaolrseofpltahsetic European Union, in particular through use of more plastic, higher carbon footprint (plastic manufacture and transport of increased weight), and higher energy consumption during manufacturing. Similarly, alternative packaging technologies (such as co-extruded HwaDsPtEe/sEtrVeOaHmso,rcHaDrPboEn/PfoAot)prhiantv,erlaiwmitmaattieornioalnarnecdycelnaebrigltyyuasnadget.hus potentially increase 6.1.04: Benefits `Suppliersof packaging to the crop protection sector will likely remain the same, as they. currently provide both barrier technologie--s both fluorinated and coextruded packaging. 6.1.g: Information on substitution not considered feasible Inthe case that forspecificproducts a co-extruded barrier material was not able to be pfrooutnedcttihoant pardoedquucatterleyqupierrefmoernmtesdotno smteoertagtehesttarbainlstyp,ortthiosfwdoaunlgderreosuusltgionodoss,soorfptlhaentproduct regulatory approval for sale. 6.2: Intermediates. As a minimum, these comments are relevant to the following sectors specified in Table A1 of Annex A: plant protection products and biocides, and chemical industry. Detailed impact information has only been provided for the plant protection product sector. 6.2.a: Annual tonnage and emissions. `The total tonnage is all approximately that of all substances within scoofpthee restriction pderroopgoastailownitthraansditeiroongapteiroinodlsownogeurldthbaen t1h8emionnttehrmse.dTiahteesululsiemadtteo tsoynnntahgeesiazteearcetxipviersyoufbstthae.nces in (Cionldiuvmindua2l,lyPa<r1aUgyreaaprhp4erresguublsattaendces)e,ctaonrsd,Csoulbusmtnan2c,esPaursaegdraipn hRe5(s1e)a"rccalhibarnadtioDneovfelmoepamseunrtement instruments and as analytical reference materials". cBoyntdreoflilnietdiocnonidnitteiromnes,diwahtiecshreignicsltuedreesdiuntnedrearliRaErAigCoHrouasrecornetqauiinrmeedntt.o bAesussuecdhutnhdeerre ssthroiuctlldy be no end-ofife or other emissions to the environment to consider. 6.2.0: Key functionalities provided by PFAS need fo`rTthheekfelyuofruinncattieodnamloitiieetsyffoorritnhteerfmuendcitaiotnesofartehadteitnearlmimonleedcublye.theInetnhde-vuassetmmoaljeocruiltye,ofancadstehse,. the intermediate will only contain a fluorinated moiety if it is required to transfer this functional group. tis unlikely to have any function in the intermediate beyond this. 6.2.0: Number of companies in the sector All companies using intermediates. 8128 62: Availabilty of alematives being usInedthteovsaysntthmeasjiozrei.tyAosfscuacshe,stihnetienrtmeerdmieadtieastaerceadnofuisnueadllbyyntohtbe emoclheacnugleedthweiyhaoruetumloidmiaftyeilnyg {troohbebuersettsluyrlaatnasnsstfuecmhreerdmteiodtchatalht.efIlnnueotrxhiensgisepipes,cpiafrinecdsecunaltsiiemnaotafenflliyunottrheiernmefeicndhaileamtpiersotodrnuylc,yti.gfitTvhheeenrertfoholeroeve,axnpitteminsosireee,taiystocinsaanibnlbteeen{0desday that for intermediates in general, no alternatives are available. An alternatives and socio-economic analysis can be performed on the inal synthetic product--s tFhoer ohuitscroemaesoonf,wihnitcehrmweoduiladteisnshehroeunltdlyrdeceetievremitnimeethuenloinmigtoeidndgenroegeadtifoonr,aanyndspaenciyfic intermediate. allematives/socie-economic analysis conducted furher downsiream. 6.2.6: Future developmentof allematives No information is currently available to GLE for tis question. 6.2. Information on substitution requiring additonal ime: Generally no altematives are believed to be possible for intermediates. 6.2.6: Information on substitution not considered foasitlo derogatiIonnt.erImfeidnitaetremsediieatuepssdtorenaom irnetchelevseuaptpllyeacshtasiinmiflraormdeprroogdautcitosn,initmemneddeidattoerleocsesoivfe aall adlotwenmsptlrinegamtopmraodnuacgtes wmouullldlfeoltliomwelaifnteers twhiehdeafsasuolctia1t8emdocnotmhpltiraannscietiiosnspueers,ioad geexpnierreidc. iImnestead a of unlimited derogation should be put in placeforintermediates. 6.3: Laboratory uses + These comments are relevant as a minimum to the following sectors specified in Table A.1 of Annex A: plant protection products and biocides, and chemical industry. Osnulbystlainmcietesdcoinuflodrmcaaltliounndiesrprthoivsirdeesdtrhicetrieondpureopotsoalt,heTvheersyellairmgietenduemxbaemrploefspaorteentoinally uisnetesndwehdictho caprrotomivmcileedrseciiananlloanblo-arbeaoxtrhoaartuyosrstyeitvsteeitnolguistnlgwishniemciohgfhattrheehankvoietn.ddeTotfhaeuilseuedssehPserFaeAr.SeTdhaisesstsieuncbmtsartyaonomcreumssaaeynodnfoctPhFfeamAlliScuanmldaetrererarigeaeslnsetaasrncidhn `and development exemplions, and total tonnages across sectors may exceed 1 tiyear. 6.3.0: Annual tonnage and emissions establisUhseed hinanldaibnorgatoofrhiaeszairsdouunsdewrasclonetrsotlrleeadmsc.onditions and the only emissions should be via 6.3.0: Key functinaliles provided by PFAS follow. `The key functionalities provided by PFAS substancesdependon the use. Some examples IMnutVaitnrtocMelalmsmdaelfiicaienntCeilnltGhyemniediMnuetkaitniaosneTeenstzsym(eOEacCiiDviTtyesbtecNaou.s4e90of) ausmeuttartiifolnuoTrKot+h/y-mi0dinTeK-(-TFaTr)o. troesTiFsTta,nwthtiocthhceacuytsoesstatthiec eifnfheicbittsoiofn tohfeceplylruilmaridmienteaabnoalliosgmuaenTdFTha.lTtshfeurTtKheprrcoofilcdiievnitscieolnl.sTahruess,emnsuittainvte cells are able to prolferate nthe presence of TFT and orm visible colonies, whereas cells containing wn tthhee sTaKmeenzfyemcetias reunnloitk.elTyh.is is highly specific effect, and an alternative fluorine-free substance with Trifluoroacetic acid (TFA) can be used in analytical chemistry as a high-performance liquidcahdrdoemdattoosghrifatpthhye(pHHoPLfCt)hemomboiblielepphhaassee,moadnidfiaesra(LreasrudletutxheH.deegt rale, o2f02o1n)i.zaAtGioindsansduchhydarsopThoFbAicairtey tofhutsheaslulobwsitnagnctehsebreeilniagblaenadleytseecdt.ioInn toufrnsptehceirfeitcenstuibosntianmceeasntdosbeleecotpivtiitmyizoefdt.heTsFuAbsthaanscepasrtcihcaunlagrel,y sdeyssitreambsl,e bpercopaeursteieistsfomrourseevowliatthielitqhuaind aclhtreommaatitvoegsraanpdhyd-omeasssnotspfeoucltrtohmeeitornys(ouLrCc-eM.S) detection 6.3.c: Number of companies in the sector All companies with laboratories involved in commercial activities. 6.3.6: Availabilty of altematives. `mutagenFiocritsyu(b.s.t,arnfcleusoruostehdymiindsipneec)i,fincotoaxkitceomlaotgiyvesstuadrieescosnuscihdearseOd EliCeDlyTteosbteNoav.ai4l9a0blfeo,rbecause the test relies on blocking a highly specific metabolic pathway using thymidine aFvoarilsaubblse,tawnicthescaussee-dbyin-caanasleytsiuciatlabcihletymifsotrrsyubassiimtuotbiiolne. phase modifiers, allematives are likely to be eFqourispumbesntta,nacneds uansaeldytiincaalcraedfeemriecncreesmeaatrecrhi,alc,omitmiesrhciigahllyruensleiakrelcyhaalntderdnaetvievleospwmiellntb,e caavlaiiblraabtlieo,n of given the highly specialized uses. 6.3.0: Fulure developmentofalternatives No information is currently available to CLE for this question. 6.3.1 Information on substitution requiring additional time: No information is currently available to CLE fo this question. 6.3.9: Information on substitution not considered feasible: are putitnischneomtirceaallilstaibcortaotporeirefso.rm a detailed analysis of all the uses to which PFAS substances 7: Potential derogations marked for reconsideration -- Analysis of alternatives and sPaorcaigor-aepchson5omaincda6naolfystihse:proposed restriction entry text (see table starting on page 4 of the af`tseurmmtahreycoonfstuhletaAtionniXnVn[srqeuesatriecxibornackreetposr)t.) iTnhcelsudeesaerveeursaelspooftePnFtiAaSldwehreograoitohnesefvoirdreanccoensuinddeerraltyiionng tthhee baasssiessosfm)ewnhteotfhtehretescuhbnsitciatlultyioannpdoetceonntoiamlicwaalslywfeeaaks.iblTehealstuebrsntaittiuvteisohnapvoteeanltrieaaldiysbdeeetnerimdiennetidfioend oprroaplotseemdatrievster-ibctaisoend, pi)rwohdeuctthserarkenoawvnailaalbtleernoantivtehsecmaanrkbeetiamtpltehmeeanstesdumbeefdoreenttrhyeitnrtaonsfiotricoen poefritohde `aennddsiii()wtahkeitngheinrtoknaocwcnouanlttetrinmaetirveeqsuairreemaevnaitlsafbolresiunbssutfitiuctiieonntaqnuadncteirttiiefsicoantitohneomrarrekgeutlaattotrhyeaappsrsouvamle)d, Aentsruymnmtaorfyoorcfetthoealalvoaiwlaafbfleecteevdidceonmcpeanaisewseltlo asusbstthiteutkee.y aspects based on which a derogation is pboetienngtiparlolyviwdaerdrainnttehde arreesppercetsieventseedctiinoTnasbilneA8ninnetxheE.Annex XV restriction report, with further details 18123 rTeoqusetsrteengdtohnenalttheernjautsitvifeiscaatnidonssocfoiro-aecdoenroogmaitciiomnpafocrtsthceosveeruisnegs,thaededliteimoennatlssdpeecsicfriicbiendfionrmpaotiinotns ai)s tog) in question 6 above. No information is currently available to CLE for this question. 8T:abOlteh8erinitdheentAinfnieedx uXsVesres--trAicntaiolnysreipsoortfparlotveirdnesataivseusmamnadrysoofctihoe-iedcenotnifoimeidcseacntaolryssaisn:d (subJ`auvsaeislabolfePeAviSd,entcheeairaelptreronvaitdievdesinanthdetrheespceocsttisveexspeecctitoendsfirnoAmnanebxanE.of PFAS. More defails on the F`aonrdmmaianlonyfqtuyhaelit(astiuvbe-.JuIsnespa,rttihceulianrf,oremvaitdieonncoenoantaelmtaetrniavteisveasnwdasosciinoc-oencclounsoimviefcoirmspoacmteswaapsplgiecnateiroincs: fsaelalliingnguntdapeer, tnhoenf-oplolloywminegri(csuPb-F)AusSesp:rotceecshsniincgaatiedxstefosr, perloedcuicrotniiocns,ofthaecreylniecrfgoyasmecttaopre,,PwTiFnEdotwhrfeiamd manufacturing, and lubricants not used under harsh conditions. pMootrenetiianlf,orpmraotpoirotnioinsanlieteyd,edanodn tahletenmaeteidvefsoransdpescoifciico-teicmoe-nloimmiicteidmpdaecrotgsattoiocnosn.clTuhdeereofnorseu,bstsipteuctiifoinc ianbfoovrem)atiionre(qfuneostteadlroenadayltienrcnlautdievdesinanthdesAoncnieo-xecXoVnormesitcriicmtipoanctrsepocrotveorrincgovtehreedelienmtehnetsquleisstteidonisn points a) tog) in question 6 above. No information is currently available to CLE for this question. 9A:foDwegSrpeacdiafitciPoFnApSotseunbt-igarlouopfssapreeciefxiccluPdFedAfSrosmutbh-egSrcoouppeso:fthe restriction proposal because of `mainceormabliinzaetiinotnheofenkveiyrosntmreunctt.urRalAeClewmoeunltdsapfporrewchiaitceh tiot rceacneibvee aenxypefucrttehdertihnaflortmhaetyiowniltlhautlmimaaytebley aevnaviilraobnlmeernetgaalrdicnogndtihteiopnostenatinadl dceogrmapdaarttimoennptasthwfoarys,tKiifnleutoircosmoertphorxoyd,ucteidflmueortoambeotlhtyelsamiinnroe-levaanndt difluoromethanedioxy-derivatives. ScoeneteCxthoafpttheirs2e,xpHearziamerndtaClhawroarcktecroiznadtuicotne,dBbiyodCergorpaLdiafteiEounroofpeP.FInASparStiucbuslatra:nces (above) for the tbaissisessfeonrtitahletaobroeavleizethtehoartettihceasleweoxrpkeriismecnotrrsecatr.e oAnslysuicnht,endtehde tporpercoivseetdheetfauilnsdamoefntthael ethxepeorbismeernvteadldceognrdaidtaitoinosn urasteedwhielrveardyowniotht meaatcthemro(lee.gc.ul2o0wChivcsh 1c2onCt)a.inTshiosnies boefctahuessee pfaurnectnitonmaollegcruoluep.sT(hee.ge.ss-eOnCtFi-al),andedpkeenydpionigntons tthhaelbtrhoeaiddeenrtcihfeimeidfcualncsttiroucntaulregorfoutphes (lasrugcehr aRsEA-COHCF.:) donotconferpersistence on a larger molecule which maybe registered under n`iTthreosgeanm,eetcco,nswihdeerraetitohnes faoprpmlaytifoornootfhesrtahbelteersopaetcoimesboonndeddegCraFdsataionnd c-CaFn2n-otGrboeupasses.ug.meOdx,ygaennd, cstoanncdeamrsd.environmental fate studies required by REACH must be conducted for proof or absence of Defluorination of "C-Trifluoromethoxy Benzoic Acid in Soil 19123 1 [Re L1 iE:I * is ee emt1,ten pt - as iJi:ie - Hy Ii 400b vox -: i nt Faciigdurpere3s.eTnthedaabtoSvEeTpAloCtsEsuhroowpepr3e3l"imAinnnauryaldeMgeraatdiantgio3n0rAespulrtsif4o Mtafylu2o0r2o3me(t3h.o1x6y.bPe-nTzuo2i1c6:. Dreepfolrutoriisnnatoiwonaovfai1l4bCl-eTriinfAunonreomxe2t.hoxy Benzoic Acid in Sol). The study summaryforthe final CderfolpuloirfienatEiuonropofe *BCri-eiffinogroNmoetteho#r3y5b6e7n3zo(iAcnnaecxid3)In fisroslt. reFpiogrutreed 3prealrieminpalroyts reosfulptrseloimnintahrey degradation data presented at SETAC Europe 33 Annual Meeting 30 April -- 4 May 2023. Aonnndeexf:lu2ocroinnattaiionnsotfh"eCO-EifClDuosrtoumdeytshuormymbaernyzofiorctahceidn.oTwhecoemxpelceutteidveasnudmrmeaporrytesd reexppreroidmuecnetdalbewloorw.k TanheOoCbjFecgtrivoeuopf cthaen pbreedseengtraadeerodbiincssoolllImneatwaaboyltihsamt stthuedCyFweagsrotuopinivsepstairgaatelfformfuollleycudleeflsuocrairnraytiondg 50 that the respective carbon atom can finally be degraded o COz. Awsasa cmhoodseelntfeosrt pceormfpooruminndg,4an<rafelruoobircomseotihdoexgyrabdeantziooincsatcuiddy raacdciocr-diianbeglteod OdiEreCctDlyguatidtehleinCeF307grwoiutph special analytical focus on the formation of "COz. Ftroerattheids,wtihthre"eCs-orlfsluroormomtehtehoSxoyu-tlhawbeeslteedrntersetgifolneofatGertamragnetya(pLpil1i0c,atLiUonFrAat2e.2o,fa0n.d67LUmFgAa.2.54.)kwgedrrey. sdoilslrbwuhtiicohncionrtrheesptoopnd2s,5focamfiselod alpapyleircaatnidonarsaoteiodfen2s5i0tygo2f.1.55.g/ccamlc.ulated on the basisof an equal Twehreosafillemdoiinst5u0regwpaorstaidojnusinteidntdiovi4du0a%l golfatshseemsatxviesmsuamls,wattreeratheodldainndgtchaepnaciintcyu(bMaWlHdCi).thTehdearskolast a temperature of 20 2C in a dosed incubation system with corlinuous aeralion for up 10 56/57 days. Sionlclubsaatimopnlepesriwoodr.eThteakseanmpaltidnagyda0teasnwderate s0,ev1e,2n,a3,dd6i7t,on1a0l, s14a,mpalnidn2g8tdiameyss attherroutgrheoauttmetnhte(DenAtTi)r.e V`oslaamtpilleeds wteogreethceorllweictthedtfhoe reeascphectteisv!ectoensttacionnetraiinndeirvi(deuaxlcleyptthartoudgahyd0e).diFcoarteedactrhapspaimnpglisnygstiemmes atnwdo roerpdleircattoe csohielcskamifplthees dweecrreoawsoerkoefdtuhpe. nOonn-eexattraicotnaablle sraemspildiunegs wisasprpoecrefeodrimnegdaaflte5r64/57wedeakyss oinf incubation. "ITnheorrdadeiroatcot_ivcihteycikn tahlesvoolaftoirlerreampapiniinnggsotlruatnisonfsorwmaatsioannalpyrozdeudcbtys liinquisdoslclintthileatsiooinlcosuanmtpilnegs(LwSeCr).s c(1o1n1s,evciuvt)ivaenldyweaxstrhaecdtetdwiwciethwi3thx5500mmLLacaecteotnoen.iiTehiewaintdeirvi(d3u/a1l,eixvt)r,act1sxwe1r0e0 amnialayczeeldobniyriLlSe/Cwaatnedr combined fracions were concentrated and analyzed by radio-HPLC. 22 sTyhsetesmoi.l ArleisqiudoutesafotfertheextdrraicetdionsoiwlawserrieedcoumnbduesrtNe;d wthoildeetbeerimnignaetttahceheadmotuonatnootfhenronC-Oex;trtarcatpapbilneg residues (NER), so that a *"C-mass balance could be provided for each sampling interval, aTnhde irnadaidodaicttiiovne bteystcoimtpemarpiesaokn ionftthheesroelteenxttiroancttsimweasofctohnefirramdeidopbeyakmeinanthseosfoimlaesxstrsacptesctwriotmhetthrey retention timeofthe **C-labeled test tm in the application solution. T72h.e7r%eosfultthseshtootawl tahpaptliaefdterra2di8oadcatiyvsittyh(eTmAiRn)e.raTlhiezatmiaosnstobaClOa;ncreesawcehrede >va9lu0e%s TbAetRweduernin6g1.t8hean2d8 ldoawyesramnadsrsanbgaeldanfcreoomf91>.8870.61%0.3.6% TAR. Orly one sampling point with LUFA 2.2 showed asightly Tbehtewaeemnou0n.t6 oafnedxt1r.a3ct%abTlAeRraadfitoearct2i8vedareyssidofueisncduebcarteioans.edThferonmon>-e9x7i.r4ac%taTbAleRraetsiddauyes0itnocrveaalsueeds fvarloume5s 2be.t6w%eTenAR26a.t0 daanyd037to.8m%axTiAmRa aotf 2485.d5atyos5a4n.d5%furTtAheRr atto 22-26.9daaynsd, 3a1n.d1%thTenARdeacfrteears5e6d/5t7o days. tTehset irteelmeasheadofr"eCacOh;edfrnoemgltihgeidsloeillsecveolnst.inTuheed edveecninaeftoefr tNhEeReSxtraafcttearb2l-e6raddaioyasctisvuigtgyeasntsd tthhuats tthhee doreggarnaidcatmiaotnrioxfitnhseoi"lCaFnsd-gwraosupparptrloycienecdoerpdordaetsepditienttohtehfeachtumtihactstuhbestbaennczeosi.c acid reacted with the rPardeicoiapcittiavtiitoyntwriatphpBead(iOnHt)h:eaNsawOelHl saosluatciidoinfsiciastiaotntrwiibtuhteHdCtIo o"fsCeOl;e.ctOethdesravmopllateislecconofmipromuenddtshawtetrhee observed at levels < 0.04% TAR. 1Du0r2i.n7g%tTheARcoautrdsaeyoOfttohevasltuuedsy,< t2h.e0%amToAuRntafoftep6rar-e1n4t dcaoymsp.oBuensdidqeusictkhleypadreecnrteacsoemdpofurnodm,9a7.f4owunidentified transformation products were detected, but al at evels < 0.2% TAR. Kinetic evaluation and calculation of DegTz and DegTeo values (tigger endpoints) for the parent 4(Krinfeltuiocrsowmoertkhgorxoyu)pb.enTzhoeicobatcaiidnewdaDsegpTe:rofaonrdmeDdegfTosllsowvianlguesthaerergeicvoemnmebneldoawt.ions of the FOCUS Table 3. Trigger endpoints of 4-{iflvoromethoxy benzoicacid at 20 C [sorte [earrr | DosTule] | DeaTwich tmz wo ne Jw lm | ii [ofr Jue fee] oTfritghgeerFeOnCdUpoSinKtisneattic1s2woCrwkgerroeupe.stTihmaetoebdtausiinnegd DtheegQTizo aapnpdrDoaecghT,oofovlaolwuiensgartehegirveecnombmeelonwd.ations Tmaobdleel 4. Estimation of trigger endpoints for 4-{riflsoromethoxy)benzoic acid at 12C Soil Kinetic 2 X* error| DegTss DegTss | Correction| DegTso | DegTso 61 [dl at| [d] at| factor [dl at| [d] at 20C 20C (frome) 12c 12c trhz2 so fms Jus [om Jaw Jew [os | trhz [so Joo Jor [om [oo Jor Jew | Ttrhaensfroersumlattsionshroewacttihoants 4o-b(sterirfvleudorwomeerthotxhye)breenlzeoaisce aocficdarisbornapdiidolxyiddeegarnaddtehde ifnorsmoaitl.ionThoef noonnl-y ewixtthratchteabdleegrreasdiadtuieso.n Tohfethheigmholaemcouulnet,stohfeCOOC;F-f-ogrrmoeudpfrisomratphiedlOyCFasn-dgrlaorugpeldyemmionnesrtarliazteed,thwatitahlotnhge rpersoicdeusess.oTfhemincearrabloiznamtiinoenracloinztaitniuoinngfroemvtehneaOftCeFrgthre oraduisoaapctniviintdyirwecatspopoarftthoafttahlesotnohne-oerxgtarnaicciaalbllye bound fsorineis fully mineralized, i. t ends up as inorganic fluoride in so. Overall, the experimental data show(1) that the presence of an OCFs-group does not automatically ltheaatvtehae Cmo=lebcoulned psernsoitsttehnatt isntatbhlee eansvciroomnmmoennltyorpolsetaudlattoedp.ersistent degradation products and (2) Further experimental work being carried out WFhuritlheerthiesxwpeorrikmiesnteaxlpewcotrekd btoybCeroupsLeiffuel iEnuerxoppaendoinngbisocdieengtriafdicatkinoonwlisedsgcheeodnultehde einnvtihreonnmeeanrtafultfuraet.e oSofllc,erwtaeinbfelluioervienaittehdamsoebieeens,sutfhfeicfiaecnttltyhadtesmuocnhstrrapaitdeddetghraatdaetxitorneamnedpmeirnesriasltieznactieonfoirs oatbsleerasvtedthien `cmooniteatiineisngfoer.gw.hi-cOhCiFnfoarrmeatnioondihffaesrenbteetonostuhbemristitnedascsaunmnpotitobnse aarsosuunmdepde.rsAissteancree,sualtn,dmtohleeccualseesby-case assessment in a REACH regisiraton is appropriate and proportionate policy option. 10: Analytical methods: A"mnentehxoEdsoffotr hPeFAASn.neAxnaXlyVtirceasltrmiecttihoondrsepaorrot croanptiadiynsevaolnviansgs.esPlsemaesnetopfrotvhiedeavaanilyabnileiwtoy orfaadndailyltoincaall information on new developments in analytics not yet considereidn the AnnexXVrestriction report. No information s currently avaiable to CLE for ths question. 4. References EC (2020) Report on the compliance with the legal deadlines set out in the Regulation (EC) No 1N1o0r7w/a2y0f0o9rctohnecyeeranrisng20t1h7e,au2t0h1o8r,is2a0ti1o9naonfdpl2a0n2t0p,roDtiercetciioonraptreodEu--ctFsoroedpoarnteddfbeyedMseamfbeteyr, iSntnaotveastiaonnd. European Commission. hiips:/icod.ec.europa.eulsystem/fles/2022-00/pestcides ppp report ms`rsuervqeyulatory-procodure20s1-7-i2m00i.n0dgf Kharitonov A. P. (2005) The kinetics and mechanism of the direct fluorination of polyethylenes. hiStuprsf:a/cdeoloCroga/t1i0n,g1s007I/ntBeFr0n2at6i9o9n5al74 Part B: Coatings Transactions, 88, pages 201-212. 22 bLiaorpdheaurxmaHc.euetticaalls(2in02i1q)uidAlctherrnoamtaitveogmroabpihlye~pMhaassse sapdedcittriovmeestrfyo.r AtnhaelycthiacraacCtheirmiizcaatiAocntao,fVporlotuemien 1156, 29 April 2021, 338347. hitps:/doi.org/10.1016/,208.2021.338347 `POarzgeannoofkluSo.r,ineetCahlem(i2s0t2r0y),Cphp.ap6t9e5r-71362:. Mhotdpesr/ndoFlluoorrgi/n1e0-C.o1n1t4a2i/n9in7g81A7g8r6o3c4h7e3m3i6c_al0s01i6n Frontiers of tThrreosusgahudflAu.orientaatlio2n0r0o7ut)esM:odFirfiocmatfiuonndoafmseunrtfaalcerepsreoaprecrhtiteosionfducsairribaolna-pbpalsiceadtiaonnds.pJooluyrmnearlicofmaFtleuroriianles Chihtepmsi:sitdyo.Lorg/1V0o.l1u01m6efluch1e2m8.,2006.1s2u.0e15 4, Apr 2007, Pages 378391 5. Annex 1 -Analysis of the potential agronomic impact from the loss of fluorinated agrochemicals in the EU Cropife Europe Position #33669. Pages 1-6. 6. Annex 2 -- OECD summary, Aerobic soil metabolism of TMC- trifluoromethoxybenzoic acid rPirfevliuooursolmyethouxnypbuebnlziosihcedacidO.EPCaDgess1u-2m3m.ary on the Aerobic soil metabolism of '`C- 7. Annex 3 -- Experimental work on degradation of CFs-containing molecules DPoFcAuSmeinnftirperfiegvhitoiunsglfyosaumpprlesiterdicttoionthperoDpoosssaile.rCSruobpmiifteteErusro(pEeCHBAri)efainngdNRotAeC#3in59t7h3e.cPonatgeexst 1o-f8.the 8. Annex 4 -- Croplife Europe information on functional groups DPoFcAuSmiennftirperfiegvhitoiunsglfyosaumpprelsiterdicttoionthperoDpoossasli.erCrSoupbLmifteteErusro(pEeCHPoAs)itaionndPRapAeCr i#n35t4h6e1.conPtaegxetso1f-1t7h.e 9. Annex 5 -- Specific comments and additional references linked to the restriction report Annex B. 2Detailed comments on toxicology studies reported in Annex Bof the restriction proposal. Pages 1- Annexes 1-5 follow, in the above order. Pagination is non-consecutive. 2m 2 caosozs CroplL ife Analysis of the potential agronomic impact from the loss of fluorinated agrochemicals in the EU 1. A recent review,overthe period 1998-2020, reveals that 60-70 %ofnewly launched `2o1r riemgpiosrttearnetdpaagrrtoocfheamfiacramlesr'asrecourrgeanntofclruoopripnreotceocmtpioonuntodoslk.itT.hese compounds form 2. Maintaining and rotating the limited pool of agrochemicals with different and new modes of action is key to ensure the sustainabilityof agricultural productivity. When `acroonasviadielraibnlger-edmeopveinndgisnpgecoinfitchceopmepstouconndtsrotlhsereegmiesnatl.ways a risk that no alternatives 3. tLhoeosCirnogpfPlruoolreicntaitoend Iangdruoscthreymwiictahlsthceoluolsds hoafvkeeyseavcetrieveismapnadctMsoadcersososf aAlcltsieocnto(rosAo)f drastically reducing the resistance management options available for EU growers: I0lno3sssteocetfnitci4irdeMelyso./AAWcgharreoircueipadses.sFtwhuoenuglhidecrisbdeieecsitdwheoeuslleodcstssoorefew9otahuceltdiovsesseseuobftsh1te1anlAcoSessswi(otAfhS)155aMnAdoSAcoagmnrpdoleuttphese `complete loss of 1 MoA. 4. Wfuengoiuctildiense,inPomtoarteo dfeutnaglichiedesp,oteOnitiSaleeimdpaRcatpsea--crIonsssecCteirceiadlesF,unPgrioctiedcetse,dSVueggaertBaebelte Insecticides, Fruit crops Insecticides, Cereal Herbicides, Corn Herbicides, Vines and Orchards herbicides. Th Importance of fluorinated sgrochamicals in crap protection Ahass'ursvheoywonf 4n5alneawropuensdtic8i4de%acotfivieeinlgarudnicehnesd upsreoddauscmoardeehralaoggreocnh-esmuibcsatluslaodve(r1h0ehelrabsitci1d0esy,ear1s5 ufuontgiicniadeosd, a1n3d airnosoucnbdci4desio5afcahr%iacimdecs,onaannda3GFnermoautpci,deapsp)roFxriomma.tetlhyes1e9,%3a1 CaHctiEveanidngarreodunnids3%arae (CF30-group as a substituent on the phenyl or heterocyclic moieties". Th imporiance of fluorine chemistrya a ool for enhancing the biological activites of active ingredients IaGsgarcwoeacldlheesrmeicfcoragolnmsiz2ste3hd.0uAtcorcflae5ma4ar3liisntdiienccdarteinaosn1e8onf77tthh1ee n1k0ue6ymboreuorlleooffth8oa6tr2fnliuasoertidenenap2lca0ye1s.iinnTghtreheedmidoenestvtseclinoophmmmeeonpntasfotuftonrreenwee `containing groups is aromatic CF-group and aromatic fluorine atom.A? more recent review, over the period 1998-2020, indicates that 60-70 % of newly launched or registered agrochemicals are `organofluorine compounds (Ogawa et al, 2020). 7a7n:e JoenanG t maSrea7a ,n ac0ssr ,Sosfht aoo oG e n rcn raiBc0,1,:O3 genshosChaity--Sys,Hoar: FroanncpnianEeoSnescsath[o3 RBuusGnueisTmeCaor1|du5t21o0246B088Biuv1s5e5e0s| o|BFpexkgc3uo2mu|S0G0Ep30e41r94n0706k1o3n87sogaptwrwof LoopglePnosrospona ners Polyfluoro-alkyl groups for example, as substituents on the phenyl or heterocydic moieties08p0l5a2y02a8n importroalenitn agrochemicals used in plant protection. This canbeexemplified by aremarkable number odfecCaFdxe-. aFnurdthCeHrFmzo-rge,roaupcocuopnlteainneinwgahnedrbiincniodveasti(v4e6i%n)soacntcdidfousngbiecairdiensg(h5e6pt%a)flluaouronsc/hseod-proovpeyrl tghreoulpass,t awlelrmeosduecrcenssnfeumlaltycliaduensc,headlrfeoradgylolbaalunccohnterdolorofuinmdpeorrtdaentveilnosepcmtenpte,stwsiptehciceosnsiikdeerfaalbl layrmiymwporromve'd. Aolvemroasltl itonxgirceodlioegnitcsa,l tahned soe-ncvailrloendme"nftlauolripneroeffefesct'c,onstuaicnh CaFss-tghreouepfsf.ectAs uonniqsuteerifceaatunrde eolfecftlruorniince on active proportes, `cmoentfaobrolmiact,iooxnidaantdivep,olaanridtythhearsmablesetnabdiiltsycu(sCs-eFdboinnddoetnaeilrgiyn: r4e8ce5ntkJriemvoile,wsme=t.aboInliacddsittaiboilni,zaitmiponr)o,vithneg ptKh.e vpraolpueerteifefsecstsuc(hH-absonmdoilnegc,ulparroteIiinpopbhiinldcitnyg (afkfeiynitpya),raamnedtetrheforinafblsuoerncpetioofn falnudoritnreanospnorpth,ysiimcpoocrthaenmticfaolr bioavalabilty) can be underlined (Jeschke, 2021). Lipophiicity is an important physicochemical parameter quantified by the log P-value; it also determines leliigmainnda-ttiaorng)etprobpienrdtiinegs. Tinhtiesraicsteioxnse,mspolluibbiflytiyt,eheda(nFdC-AXD)MgErou(pasbso(rXp=tiSo,n,0),diwshtriicbhutcioonn,lrimbeuttaebtootlhisem,pesatn'ds Movoerreaolvlerp,hatrhmeacionlflougeinccaeolfacftliuvoirtiyneboynemnhoandciunglothafebtiionlisoegocitcnaclenptrroaplernteiresvoofusansaycsttiveems(uCbNsSt)anpceene(tArSa)tihoans.. bAeleuonrdinees-ccrointbaeidniinngdsetuabisltbityusentshoinftiobiboifloolgoigsciacallaactcitviivteyairnigsriendgifernotsmtshuechainstrtohdeuctcioomnmoefrcfiluaolriizneedatinosmesctaicniddleosr. y-aminobutyric. acid (GABA)-gated chloride channel blockers (phenylpyrazoles), sodium channel `modulators (pyrethroids), or inhibitorsofchitin biosynthesis, type 0 (benzoyl urea)'. "The roll of fluorinated agrochemicals in resistance management dPioflyefrleunotroi-nadlkiycla-tiognrsouspuschforasexhaemrpblicei,deas,s isnusbescttiitcuiednetss/aocanritchideesp,hefnuynlgiocridehsetearnodcycnleimcatmcoiideteise.s Tchoevseer bboelnoznagmidtoos, dcifaerrbeonxtamicdheesm)icaalnd gorfofuerpsp_ot(eNn-tphmenoydleismidoefs,actibountontohlaitdeasr,e crdiitaimcaildesin/caerfbfoexcatniivelidaensd, caonmpelxetmreemnetlayrysepreisotusmagnlaogbealmenatn.d Rienscirsetaasinncge tporcohbelmeimcaflorpefsotoidcidpersodiuncatlioinn.diTcahteiroenfsoirsec,onasnideefrfeecdtiavse. r(eHsRiAsCta)n"c,e ImnasencatgiceimdeenRtessitsrtaatnecgey AicstimoanndCaotmomryi,tteaond(ItRhAeC)H'erbaincdidetheReFsuinsgtiacnicdee ARcetsiiosntaCncoemmAictttieoen `Committee (FRAC)'?havebeen dedictoamtakeindg thariealisty for the past three decades. Regardless. of numerous research programs, only a fow now modofaoctison have entered the market n the past30 years. Maintaining and rotating, let alone reducing the limited pool of agrochemicals with diferent and new. `amsosdiemspolfyancotiaolnteirsntahteirveefsomriegkhetybneotavtaoielanbdlaendgeepresnidgeninfticoanntltyhethpeessutsctoanintarboillisteygomfenagtr.icultural productivity 1In6d%eebd,ywdiitsheoaustesa,de1q8u%atbey pilnasnetcptrsoatencdti3o4n %prbodyuwcetesd,sy"i.eldIncaadndibteiorne,dgulcobeadliazlarteiaodnyatnoddacylbiyma--teocnhaavnegreagaer-e ernevdirraownimnegnttsh,e lagarnidcsulctauprealoafnpdlafnotrepsetsrty pdirsotdruicbtuitoionn,.eTchoissytsrteenmdspaonsdesbiaodtihvreerastittyoinnatthueraEluraonpdemaannUangieodn tbeerainotriyc.iFpoatreid nevsentifac5on0unct0re1ie0,s0mpeeertcetnhteiinecxriesatsinegincopmmeitsmetnt-snctordorpeuldoucscseeegsridenenEhuoruospeeagnaswheemaistssihonosu"l.d 3 GE.Cork,2006,rep Loss opis.JounalofAruburlSconce(2006), 14, 31-45. cbf aotsACeDoSt.ehc,oa J.J31 TAeuwnk0sbTuaru yolW-T36o,chslsac orc,6oO4.0k55,.epnBs.a1e t6i.h9s5.o1g9.0M1o0t r.d1a1s2ce6rdceiarosocnincartospiloos>ses to satpais aworming ErGRCoao G,uscToomkn I,unmgao5gaerR.ya .oEcKnaodnbl cae8e.y,73a.3sM,heO1in0,.7s4c6i7rh.l,,SReK.cae&niSthsiapsot35alm,c(a2o0tC2o0oen)rse2or0r2c.Ca1o5e3riincaonpporffOecrtgna-nnoenw diCsocomvperoiuesnadsn0ah fom ho. Hak7keeMrpaariLto&raso.uSGecon,LaHohnldpo,onT,h7osoi0ro:r.anAFcecofu aaiPdirfoc eseoS1m2c0na 1hce8e)eW,so5s,cPo6n7c-eh 6s2.C0ha ina(Mm 2o00c4c5a i8a, 8D5ic.a9g9n.oso is, au ndAgt rocpa,mes,(06G.. 7AG.TTrssahud.eEolocvorrdAercooenriaanr.ing(ad23000c8h)sepmpi.c.a1l21175ovr ofrcantSevanpmentsn, AdvnaPhnircScearcse, ol 2,00. Sesh, Lato:gurationofhkogenp-eicceosnPosatMannan,Sgi2017),73, 1055-108. 216 `Adequate and sufficient pesticide modeofaction options need to remain availabe o face tisod0ysn2a0m2i3c and to sustain agricultural productivity. The agronomic impact of loss of fluorinated agrochemicals in the EU Linodoussitnrgy fwiltuhoritnhaeteldosasgroofckheeymiaccailisvewsoaunldd hMaovdeesseovfeArciiomnpa(ctMoa)crocsrsasatlalsleyctroerdsucoifngCrtohpe rPersoifsetcainocne t`hmeanaavgaelmaebnitlootpyfti6onMaovAaigarbolupfsoraEnUdgrreoswuelrtsn.tIhnesaccoimcpidloestieAclaorsiscoidf4oswMooulAdgsraoeupst.haIln thoeofEs9UAsSfu,ngiicmipdaecst. lWoosutledntsiereelyt.heWhloesrseoafs11tAheS,heirmbpiaccitdethseecatvaoirlawboiultlydofseseubtshteanlcoesss ionf81M5oAAS,griomuppsa,ctwitthhe5avMaolAabgirioyuposf Substances in 7 MoAgroups andsoe the compote oss of 1 Mo. sEuxgpogretstjutdagtemfoernPtPoPn thtaergientteirnatcetrioanctbioentswceoennsiidnehreerdantmerdesiiusmtainscek raiskeafsactto3rsMoanAdarreesniseteadnecde mwohdiisfiiefrosr smcaennaagrieomsencton.siIndemredaohifghnth rcisyrkopthseenctaormsimneinmtuimoneodf b4elMoowAthewonuulmdbebreofneaevadieldablfeoransudsetfaifncaibilvee Mpeost cahreemiasltrreiaedsy. limited and further losses of AS and MoA would exacerbate the resistance risk on other Cereal Fungicide wGhoircehalcsanarsoiggnirfoiwcanntilnyalfafregcetyqiuealdnianidsqaucarols.sKtehyecoEuUntaineds airneclsuudescGoerpmtaenyt,o Farawnicdee,rPaonlgaendo,fRdoimsaenaisae,s pReecienntanredgHulaalt.orTyhmeenasuuresomhfaMvbeoAseegernotruhpesloasvsaoilfabalenfuomrbtehreocf moullonsfcetrsoelaulrtidoinoss,eawlsheiscihs aaplprleyadiyncmreiaese,d apgraeisnssutrokeoynctohreelredmiasienaisnegs.ATSh.eSloDsHso(fMfolAuogrrinoautped7)agarroechaeemliactavleslwyounledwsaonedtvehreyrefefmeocvtailvoefM2 o0ugorfo1tu0p AS current avaiable. pAcrtoigvreamssu.bsMtaanncyesDfMrIo'm tahreeDaMlIrecadhyamaitstirsykgrrooump t(hMeorAeggurloautpor3y) sacrreutihnaycuonmdeerrstroenguelaotficoenre1a1l1f0u7n2gi0c0i9d.e fFuuorrtihneartleodssaogfrKocehyemDiMc'alssi,nt2hriisamzaolroksetwwoouuldlbdesleovsetraflryolmimtihtistheimpaorvtaanit glroaoufpb.oifelcttvyesolutions.With no wInidaedd-istpieocn,irtuhme Qacoiiftuyn.giOcindeeso(fGrtoheuspe11a)ctairvee asukbesyptaarncteosf twhoeultdoalosolfobbefuonrgeaxmlovceondtrforloimn ctohrealopstiwointsh avaiable. cIunrardednittliyonr,egFirsatnecreed, fGuenrgmiacindye,s fPoorlpanodwdaenrdySmpialidnewwocuolnldrohlanvecaerleoaslso(fG1rouunpiqUu0e6)m.ode of action from the SBaDsHesd otnhrtehaetveenrdyilsoewasne countromolfaMcbrooAsewsiEtruhrinopteh,cerceorpelaolsfsuensgiocfidbeeatrweeaetnh 4l0os%s(oyfelalsoiwgnuisfti)caanntdnu2m0b-e2r5o%f (iSmeppatcotritah)ecaabnitbyo feoxpceoncttreodl iSfocpolnotrrioal faansd.yTehlloowloasnsdofbrSoDwHnI raunstd. kDeiyseDaMsIe'scoinntrwohleiantbwaorluelydwsoeurliodusbloy oifmpraecstiesdtatnocaentoeveexnisgirnegatecrheemxitsatnrtwyitinhtkheeyrdiesceaesens tosufocahskaessy mNuelttisbiltoetcahc,tiRvaemuslauriba,stRhaaynndnchhciogeshpolrevieulms akoady making disease management dificult, Growers can manage disease ritossomke extent through Fr*P.eJsersrn.ve,iOF.LG ooveen.u Cr&LoiFssL:So acArosrc,esTahPrcdrlsaesocf(amB0cri1ais)nc5,i7d.n6hn91dt6e1iB.n ofogrse3a0c4AeTlianrirectoar.(AGC.HR)acsoempo aaRrofsrtHCe- axrgmi,eonn1S.VK teuy,,iVeocccoenC,ohp210t)e 0o5ok.n5r C32a.mie npei(,RrVALC)1HFosrctdee.ds3saldchaeon(s0.taFnocesvm.nW,orvly ImnseoNhcreint,V,CnoSdtre...CVopaSpPnatte1A0,hCo5tmp$o1Au0Mn1Udc5.lCo.nFacIaRdAes.aciaiddis(sohnoandms oetaW. ciienrdds.uKoamoenr. Ue CTDoRpavsavno12: SForcoFR3Ar Ladoidt so(c6.teFed, osc,eWeandrestWann1'0o.f SgeienroVV CHisCo ,rWopePrs re.to(201955 S7o.pRotofrteaS.t.Jeoenrosan ani.mHaenbnoche201.cEtPPSOBuublTleis41,c43h2-a43T8,Raensainomaarnag,mer inEe:prkmiy a8 selection of specific cereal varieties however it is important to also remember that crop poraoutesc0ti2osn products also heltpoprotectvarital disease resistance n the medium to fong term. `Sugar Beet fungicides "cThheeminsutmribeesreoxfaaccetribvaetseadndbyMothAe irsevceernyt lliomsisteodffokresyuDgMaIr'bseeutsecdurirnentthyerseulgyianrg bperiemtarcirloypo.nAQokle,yadnidseDaMsIe Cinersceonsspiotriayhaisn wEiudreospper.eaTdheresyiiseltdancleostso GoonltchhiesmsitsrtartyegaincdctrhoeprefaorremcaonnyceMmesmabbeorutSptoatteentsiaclaOuMsIedsibfyt nCeerecdoesdpsoormaaninaagbosdeinsceeaosfegsoiodtidsiismepaosretacnotntcrroolp.can be up to 20% sugar yield. New MoA are urgently `FGraenrcmea,nyGethremraenayreacnudrrePnotllaynodnlayr7e mtohedelsarogfesa!ctpiroondruecgeirssteorfedsufograsrubgeaertbe(eEtu,rotshteata,dddiatitoanaflrolomss20o2f2S).DHIIn be(MeotAfugnpgi7c)idcehsemwiosutlrdy wboeurleddurecseudlttonoanflu4yrtahcetrilvoesssuobfsatamnocedseaofnad4ctmioondgersoouf.atIinoPnolaInndFrraengcies,teGreerdmsaungya,r aPcotliaonnd,woSupladinreamnadinlfalryomontlhye acusritnegnlleyDrMegIisftuenrgeidcisdeu,bsftraonmcetsheincusrurgeanrtboepettions of 2-3 from this mode of Sdeovmeeloofpmtehne iodrenrteigfiisetdraatcitonivpesha(see.g.inScDrHoIpss sauncdhDasM)suagraer breeleat.ivLeolyssneofwtthoestehenemawrakcettivaensdwialrlenosttijlusitn iinmcpraecatseexitshteinsgelreecgtiisornatpiroensssbuurteaolnsothfeutruermeapirnoidnugctModAesve.lopment on key European crops and significantly Potato fungicides dPeosttartooyilantgefboilgihatg,e acnadusbeydibnfyecPthiyngtotpuhbetrhso.raIiinfoansteanofstihseafmoawjpolradnisdeiasseeasoefsptohtaatcoaens cabasuosliuntgellyosdseesstrboyy aupctroop,15parpopdluicciantigoans1b0ei0n%gcursoepdpleosrss'.eaFsuongni.cAidnesefafercetiavne diimspeoartsaenctonctormoplopnreongtraofmmaetewobulilgdhtucsoentbreotlwweietnh 4Th8eAmSosftorimmuploartteadntasEsUolcooourntmriixetsurfoerpprootdautcotspraopdpulciieidoinn abclcoocrkdsianngdtosepqruoedunccteioonveirn t2h0e2g2ro(wEuirnogstsaeta)soarno.. `Germany, France, Poland, The Netherlands and Belgium. CTuhrerernetcleyntthelroessaroef k1e2yMmoulAtirseitperessoelnutteiodnsinhEausroppleaacnedcardodpitpiroontaelctpirnesfsourrleatoenbltihgehtacvoanitlraoblleinsipnogtlaetoseist.o athceiiirveMso.AF-ugrrtoheurplroesssuletsinwgouinldlossseethtehceormepmloevtaeloosfs3oAfS3,MeoaAchaogfatinhsemthbiseivnegrythcehaslolleengrienpgrepsaetnhtoagteinv.es of Grape fungicides AiscraossesctEourrowpiteh, ognreaopfetyhieeldhaignhdesqtuaulsiteyocfafnunbgeicsiidgenisfwiicatnhtl1y0itmopa2c0teapdbplyicaatiroannsgeroeqfudiirsedeatosecsontVriotlicutlhteusree dreissiesatsaencse? tPootwhdeepraythmoigledne,wtsheraefmoraejomrandiysdeiafsfeereonftgmroapdeevsinoef,awcittihonmaorsetrveaqruiierteidestohaevnisnugrenolonggenteetrimc mdeavnealgoepmmeennttwohficthhirseqduiisreeassea.diIvnersaidtydoofnd,ifebroenlttmsodisesaofhiacgthioins.kDpoawtnhyogmeinkiienw tanedmsa roafngreeosfisottahnecre diseases can also severely reduce yieki. GSpraaipne, pFrroadnuccet,ioanlyin,EPuorrtoupgealcoavnedrsG3e,r1m3a2nyth.ousandha (Eurostat 2022), with the largest producers being "FTrhaelnocessanofdfGleuorrmianantyedaangdrolocshsemoifc4alofstwhoeulcudrrleenatdlytortehgiesltoesrseodfmo3duensiqoufeacmtoidonesinoPforatcutgiaoln, in Spain, aly, AvMuannocare,r,An:Mo(z1l9a9o8ct,hU,GnDi:oveStrostroao,offCoMnir:nekcPtaiscsuhta.,oIsW.etCdorewePisen,rsRPt.eMasGannractageei,menMe Pedo25wa,iErraydWyisBdkow20:2a1n.d5g.Li1at5ee41sB.lor aofNPaorsatg.ementand ars OSR-Insecticides onus202s Taphheidpeiaschre-sppoolnastioblaephfiodr aranndsmmeiatliyngcavbibuasgoes aipnhaidutaurmenthaenmdaicnanaprheiddupceosttshoofyiOoSksR.byTh2e0%P.eaTchh-aprootaatroo cchuorrrdeonttoynaolnloyrg2anMomoAdualvaatiolrabsl(eMaOgAaignrsotuapph29i)d wiinthOpSeRa,cht-hpeosteatboeianpghipdysreatlhrreoaiddyss(hoMwoiAnggrhoiugph l3eav)elasnodf sreesviesrteanicmepatcotpoynretthheroaibdisltayctroosgsroEwU.OSMRoingEruoruoppe2.9 in OSR would disappear and its loss would have tTohehilgohssdoafmkaegyespyroefthOrSoiRdsd(urMionAg gtrhoeucpr3oap)easgtaaibnlsitschmaebnbtagpehasstee.mTfhleea rbeeceetnlte ilnosasutofumkneypenreioondicwoiflilneoaidd Bceheetmliestcroyntfrorlo.m TOhSeRlocsrsoposfakleryeapdyyreptlharcoeisdsexagtarienmsetpwreeesvsiulrseo(fCotuhteorrheymanicnhiunsgsApcpt.i)vweosuwlidthbreegsaervdesretosCinScFe there are no other solutions after the wintertime to control this type of pests at low temperatures. NPoolrltehnebreeFtrlaencies,aGevrermyaniym.poProtlaanntd,peCszteicnhORSepRubilnicn,orHtunhgeamrya,ndRocmeanntiraal..EuTrhoepeb.eeKtleeyccaonunctaruisees sienrcilouudse yyiieelldd rleodsuscetsioinn bcoatnhowcicnutre'r. aTnhderseprairnegcouirlrseenetdlyroanpleyctrhorpese, MaondAfaoprpsrporviengd ofolrseuesde aragpaei,nsmtoproelletnhabnee8tl0e:% p`ysraemtphlreosidosf,boexeatdlieaszicnoelsl.ectaenddinneEounriocopteinsoiindcse.aRtelseiasstta1n9c9e9,toapnydreptrhroobildeminssweictthictihdeescohnatsrobleoefnthreecboeredtelde iinn tinhseecftiiecldidehacovnetrboleeisnawlirdeealdyy lriempioterdtetdo2.MWoAh.erTehepylroetshsveosidofrfeusrtihsetranAcSe wiis.thpirnestehnets,e tMhoeA-mgorsotupesffweoctuilvde be catastrophic wih significant yield losses anticipated. Protected Vegetable Insecticides CTuhceurlbosistaocfeAaSwoinulMdoAbegrcoatuapst2r9opahnidc,kKeeyypycroeuthnrtoiiedss iinncMloudAegfrorouppro3taecatgeadinvsetgaepthaibdlse ipnroSdoulcatniaonceianeclaudned. TpehstsNewitlhlehralavnedas,biFgriamnpca,ctItoanlyvaegnedtaSbplaeinp.roDdiurcetcitony.ieBlidolloogsisceasl asosluatironsstaroefvniotruesffeesctriavnesamliotnieeadndbythtehye. need an IPM approach including chemical PPP's. Wvihriutseefsl.y aUrnedaersetrhieoucsurprreonbtlpermoipnosparlotwecetewdocurlodpsperoedutchteiolno,ssacotfinfgivaesAvS aegaifcnosrtetcWohniooemfilrcyaalsclryosdsam3agMionAg Ggrroouupps2:9)p.yMreotAhrgoriodsupM2o9Awogurlodupdi3saa;ppAeaCr.HVR (e fMeowAerfgfreocuytpiv4e)saolnudtiCohnosrrdeomtaionn,alanodrgtahnesmeodwuolualtdobres u(nMdoeAr extreme pressure if growers were reliant on such a miled selection of produc. aLbespoilduotpet.eraThpeestlionssproofteckteeyd cpryorpeptihnrgoicdsonainodnsvoclotnatgroel-dteaprgeentdsenstuchsoadsiHuemlicchoavenrnpealarblmoicgkeerrasanadgaTiuntsat einpiEduorpotpeeraansppreoctieecstewdouvledgehtaavbeleaprboidgucitmipoanc.t and would sce the effective loss an entire MoA group (22) sIteirsionuostakbnloectkh-aotnifefafencutmobnemrinofoirncsreocptisciwidtehAicntitvhevSeugbesttaabnlecseesctaorreslionscteonthmeaajovraiclraobpsi,lottfyhecnrotpheprreotweiclltiboen products are already limited. Fruit crops Insecticidos uMnadneyr itnhseec1t1i0ci7d/e2s00u9serdegiunlafrtuiiotncrinopEsuraorpee.alFrueratdhyerunldoesrs soefvkeerye ArcetgiuvleatSourbysptraenscseusrewoaunlddahreavbeeisnegriloousst eFfrfaencctes,oGnetrhmeaanbyi,itlytatloyparnodduScpeaihni.ghStqounaleitfyruiftruaitreingEruorwonpei.n kKeeyycporuondturcieesrssoufcphoamsePoflruaintdi,ncFlruadneceP,olaalnyd,, `Spain and Greoca whist citrus crops are grown primary in Spain, Italy and Greece. bLeacrisesMo(nroadiHasnssenenrsoFPrmotscitnonoVbooluemea23p,oh(Bsa1s,aananpys2L0)c0o.pPaages 4546Econaricdamagersh modefo pon FIeRluopnaeeSDtaioftofi.Pon9s5taM.)a3ncoargoertmeScedinrctRe,OVOol 6B7.ushs ho620t1,iynetResosiscancoemaCnokaming in(ERuArCo)pea peulaionsof sis `agSaoimnestsuabpshtiadnsc(e0s9.arOeyasnapimhpsorptiaannttaogoilnefaoraanpdhiAdphciosntproolmi)n IinPMspepcrioaglrtaymcmoesp.s Twihlelpooatdenotih!iglhooslaseosvfezlusosozef hdaembaeggeisnnbinogcaotfsseeabseonne.ficial n orchards aro not good enough to control mentioned posts specially n iLeupisdfopittercaropssu,chdaamsacgoidnignlgeamvoetshsa,ndearfuo,lrresd,oianng tlheeafqmuinaelrosifattrhyoe suertioaunsdpceosntssaoqfuepnomley,sgsntiofnceaanntdy ianmtpraecliynagnmdsaervkeeretlayblimypdasc.t tThohoabVilotlylatgec-odnetpoelndeepnitdospoldriaunm pcohsatnseiln tbhoocskeecrsopMso would be removed Coreal Herbicides cTehreeaclosmwpolueltda hlaovseoifmtphaeciInohniboivieornalolfiPchayltoweeneedDceosnailroulrasster(aMyoAa3grtoiuspm1o2d)emoofdaectoifonacitsiomnpionratuatnuomrn cIonnhtibriotlioonfosfpPehciyetsoewnhsicDhessahtouurladseno(tMbOeAlgerfouupni12s)prminogd(.oef Vaicoiloansapnpd, tVheeroAnLiScacsopmpp).ounThde(lMoOsAs oofrotuhpo h2)e,rbiinciaduetsuminntwhilel mdararmkaetticcaolnltyromlpinagctthhoseecdonitcrtosl owfeeVdiso.la Ismppp,ortaVnetrocnoiucnatrsipeps. inadnuddfeeaFvreannceo,auSptaunm,n Romania, Poland, and Germany. Tasinhgdeni(lfAocpsaenrotafytshtpheiecAacLvSoocnto)mopifonguRrnoadmsassne(isaM,iokAePgo(raBonrudop,m2uC)szae3ppcpphr.o)RvieenpdukbienlyeE,cuoruSonlptoreviafekosirasa,uucathnudmansGeaFrprmpalanicnceya,.tioSnp,aiwno,uRlodmiamnpiaac,t tThoeneinrcerseiassteadncreelpiraenscseourne ALS and ACGase producs or conrl of grasses i spring would further add Com Herbicides bTrhoeadlossopefckteryumASpoisntMeomAerggreonucpe27gwraosusdainndcredaisoelthceonptroels,suwrielohnrtehseisrteamnacienianng AiLncSreparsoidnugctpsrgobilevme. feoslpleowciinaglpirneE-cehmincohcohrlooaa.ceTthaemipdoss,t-heamsdilvaerrgseiltyy kofepHtPrPeDs,isAtaLnSc,eatuoxainmainndimPuSm icnheEmuirsotprei,esbiun croegrunlautsoerdy iopmtpiaocnst.s oInmpeoxritsatnitngcporne-ceomunatnidespoinsctl-uedmeAFrSanacned,hGeerPmaFnAyS,pSrpoapionsaallsy,coRuolmdalneiaav,e Hgruonwegrasr&vyerPyolsahnodt of Vines and Orchards herbicides TFuordtahyerhleorseseis lwiomiutedpnacutmASboaefcArrSosson3vMinoeAs garnoduoprsch2a.r1d4s,farndth1e).cPoronblteofmrrwoaeseldssankdebrCooandylzeaafswpepedansd. Lbeoslevesrpepl.y hchaavlelelnigmeidt.ed Tehfeesceiespceocnitreoslhopatvieondseavnedlospuesdtariensaibslteawneceedtommaunlalgleememnotdoef hoofsaectciornosp,s wtihle WJoosusldofemxualcieprlbeatheertbhieciadlersea(dfyazahsiuglhurwoene,dpperneosxssuurleasm,anfdluaiznifcorpe,asoexydleuvoerlfoepn)meonrt fosf mreasniastgaenmceenitn countries such as Spain, aly (Conyza spp and Lolium spp) and France (Lom spp), oe BASF SE + 67117Limburorhot, Gemany Wo croat chemisiry OECD Summary Study Title Aerobic soil metabolismof "C-trifluoromethoxybenzoic acid Test Guidelines USOEEPCADOgPuPidTeSlin8e353.047100 Authors. Test Facility AgriculBtAurSaFl SSoElutions Ecology aSnpdeyEenrveirroSntmreanstseal2Analytics 67117 Limburgerhol, Germany BASF Study Identification Number (Study ID) NG_935316 [BASF Registration Document Number (DociD) 202312027022 eersootoohthFahnanRsQndoyTeBAteGnRaEo ArSe ntBaASGr,eWirYvSsRoOnyABE,A roaSrtbastr Fontana ansoosaz RReeppoorrtt ayuetahrors Report title Report No. 2`A0e2r8obic soil metabolism of CiNfGlu0o3r5o3m1e6thoxybenzoic acid Guidelines followed in study EPA OPPTS 835.4100 (2008) Test Facility B`AOSEFCDS3E,07Ag(r2i0c0u2lt)ural Solutions Ecology and Environmental Analytics 6S7pe1y1e7reLrimSbturragsesreh2o, Germany qDueivdisaltiinoens from current test No Le No Executive Summary eInnvgiernoenrmaeln,tmboelceacuusleeos ctaherivnergy taabClFe--Cg-rFo-buopnda,reAnadssnumcaesdestowhbeerentohne-ydaergerdaeagbrlaedabilne,thei is expected that they will form persistent transformation products. The objective of the present asrobi sil metabolism study was to investigate f molecules `GceafrlruyionrgnaatneOd-sCoF-thgtrohuep rceasnpebceiidveegrcaardbeodninatsooiml icnaanwfainyaltlyhabtethdeegCrFasd-gerdo0upCiOs .partially or fully GArsoaupmowdaesl tcehsotsceonmpfoournpde,rf4o-r(mriinlgoraonmeatehroosbiycbesonizloidcegarcaiddatriaodnics-taubdeyledacdciorrdeicngat 0thOeECCFD Quidsline 307 with special analytical focus on th formation of "Cz. For his, three sols fom the Southwestern region of Germany (Li 10, LUFA 2.2, and LUFA 2.4) were treated with "C-trifluoromethoxy-labeled test item at a target application rate of c0a.l6c7ulmagteda.osn./tkhge dbraysissoiolf, awnhiecqhualcodrisrtersipbuotnidosn itnothae tfioepld2.a5ppolmicsaotiilonayrearteanodf a2s5o0i dgenas.si.t/yhao,f 1.5 glem, The soil moisture was adjusted to 40% of the maximum water holding capacity (MWHC). The fs{oohirelusdpawretkorae5t6f/ail5lt7eeddmaipnyes5r.0atgurpeoorfti2on0s.in2indCiviidauacllgolsaesdsitnecsutbvaetsisoenlss,ysttreeamtewditahncdontthiennuionucsuabeartaetdioinn Sinociubsaatmiponlepserwieord.eTthaekesnaamtpdlian0gydaantedsawtesreeve0n, a1,dc2i.l3o,n6a7l.sa1m0p.l1i4n,gamndes26tdharyosugahfoeurtethaeiemnetinrte (DAT). Volates were collectedfo sach test container individually through decicated rapping Sspayemsrpftloeirmnmsgedainadmtes5a6tm/w5po7ledrdeapytlsoigcieanttehoersrdoewlrittshoatmchpheelcreeksspfweetchrteievdeweotcerrsketeacdsoenutopaf.intOehrenen(oenxa-cdeedxpitttroaantcatdlaabyslae0m).rpelFsioinrdgueewasecihss proceedingafer 4 weeks of incubation. T(LhSeC)r.adiIonacotridveirtytoincthheecvkolaaltsioleorraprpeimnaginsionlgutriaonnsstwoarsmaatnoalnyzperoddbuyctisauiindsoslc.intthleaisoonl csoaumnptliengs Were. consecutively extracted with 3 * 50 mL acetonitrlehatar (91, viv), 1 x 100 mL acetonitrile/water (1/1, viv) and washed twice with 50 mL acetone. The individual extracts were Paez won mrss `analyzed by LSC and combined fractions were concentrated and analyzed by re radio-HPLC. trapping system. Aliquots of the dried soil were combusted to determine the amount of non`extractable residues (NER), so that a "C-mass balance could be provided for each sampling Th radon test fam pk in he sob exc wes a Sconodinbi y orenarstof mass A ---- `and 72.7% of the total applied radioactivity (TAR). TT Sy 2 The mass balances were > 90% TAR during the 28 dosndrr days and ranged feB12 100% from 91.8 to 103.6% TTopatrnstof elrealTdatSi tegises dSepcraeefd1om T47.A0%TTAATLA on0000 De oe ed A a LL rs The release of "CO; from the soils continued even after the extractable radioactivity and thus the degradationofthe '"CFs-group proceeded despite the fact that the benzoic acid reacted `withtheorganic matrix in soil and was partly incorporated into the humic substances. S T ITL y IA SS AT TONe l STL eSmOmAsGEl Precipitation with Ba(OH)a.s well as acidification with HCI of selected samples confirmed that a few unidentified transformation products were detected, but all at levels < 0.2% TAR. oo Kinetic evaluation and calculation of DegTso and amie DegTs values a8 emnado) fr (trigger endpoints) for bethe Tiggerendpointsofrfupromethasybenzac sid 120C [sor iretomeso|pororpa | vested| bourne] [oma Tw 1 on | wo | an | TirecToommeSnndeanEnEFOOUE S KetsGwTaa.PTTio70.neas CGegeToaend STorHee pons wor sr: ds [Estimationoftrigger endpoints for 4(trifluoromethoxy)benzoic acid at 12 C DegTso[d] | DegTs [d] [[oirmwzz||ssroo[|woroo || vews||soemr[| z2m ||eosw|| ewee|| [ormza|sro |zs[ow |saz | zis[er|ow| Ee a `The results show that d{rfluoromethoxy)benzoic acid is rapidly degraded in eed soi. The only `demonstrate that along with the degradation of the molecule, the OCFs-group is rapidly and a man oo mn rnirns largely mineralized, with the process of mineralization continuing even after the radioactivity Overall, the aed my experimental data show (1) that the presence of an ond soe OCFs-group does ohnot degradation products and (2) that the C-F bond is not that stable as commonly postulated. -- ast boc 2am |. MATERIAL AND METHODS A MATERIALS 1. Test Material Aremaitxmtuerne.oDfe"t"aCi-lreaddiionlfaobremlaetdioannodnutnhleabteelsetdf4e-m(tirsipfrlueosreonmteetdhobxeyl)obwe.nzoic acid was used for soil GRehga.miNcoa.l name (IUPAC): a4-2{rr1i0f7lu8oromethosy)benzoic acid Molecular formula: CHF: Molecular weight: 206.12 g/mol (unlabeled) RaBdaitoclhaNbeol:: t1r3i5l3u1or0o0m1ethoxy-"C Specific radioactiviy (ai); (1600.91,50M00Bac/pmmigug) CRahdeimoiccheampiucratly:purty: ~~ n99a.9% Solvent acalonitie u0n0l0a1b4e4le2d022 (nacand rom Sigma Adc) 9n0a.9% none wl ~ Structural formula: I J 9 Q 250i Three diferent sols from Germany were used in this study, Li10, LUFA 2.2 and LUFA 24 oWiftthhiensfaiivse. years prior to field soil collection, no plant protection products were applied to any AatlBoAiSsF,wealrlesopfasssweedrethsrtoourgehdain2tmhemasrikevaet aanbdoustub4seCquuennttilyfusrthhieprpepdrotcoesBsAiSnFg.. TAhfteerstaorrriavgael d{iamyebbeeftowreeeenacsohilapspalmipclatiinogn,anthdeaspopillicmaotiisotnourfe twhaostedsetfeermminweadsalnedss5t0hagnctrhyreseoilmoenqtuhisv.alOenntes waactherwheolrdifniglecdanpaoci1t8y e(sMtWcHoCnt)aibnyeras.ddTihnegswoaltemroitsotueraechwatsosatdcjounsttaeidne0r.3T5h%eoftetshtecmoantxaiimneurms were closed and sored at oom temperature over ight. An overview on the soil paramaters is given below. Preset SS = oErr | oemo || omnn [poll designation (22/1680103) (221736103) (22/1807/03) TouslcissUSDA) |saryloam |sarayloam | tam | `Sol texture (USDA) [%] oe Organic carbon [%) 1.07 2.14 Eim me ||w ww w | ow | onCac oH (0) 1) [omol'kg) [sw [ses |e | [es | es[ewe| Img C/100 g dry soil) - Prior to applicationofthe test item, soil moisture was checked and re-adjusted if necessary. The target application rate was 0.67 mg a.s./kg dry soil, which corresponds to a field application rate of 250 g a.s./ha, calculated on the basis of an equal distribution in the top. unlabeled test item (in acetonitrile). The application solution was diluted in water and vessels was sufficient to allow for duplicate sampling at each sampling time plus several reserve vessels. The total amount of organic solvent (from the application solution) added to (total applied radioactivity). ASFose 20232027022 `gTahseweaxislhiinnggaifrlwaseknstfitlherdowuigthha trapping system for volatiles consisting ofa sequenceof three ((21)) 4455 mmLL 0et.h5yMlenNeagOlHycol (3) 45 mL 2M NaOH Volatiles were led through a dedicated set of wash bottles for each test container. Tcohnetewneti.gWhhteorfetnheeciensdsiavriyd,ualevtaepsotrvaetsesdewlastwearwsasmonrietpolraecdedupboyndesiaomnpilziendgwattoecr.heck the water 2. Sampling Eight sampling times were scheduled within 28 days after treatment (DAT). One additional `sampling was performed after 56/57 days in ordetro check if the decrease of non-extractable sruesmimdaureiszeisd pbreloocwe:eding after 4 weeks of incubation. The individual sampling dates are SSooiillLLiU1F0:A 2.2: Soil LUFA 2.4 00..11..22,,33,.66,. 1100,, 1144,, 2288,, ((5567)) DDAATT 0,1,2,3,7, 10,14,28, (36) DAT AVotleataicehs staramppsli(negxcteipmte,fotrwdoayre0p,liwchaeteretenstovtersaspeslwserweerteacshaemdp)l.ed together with their attached 4Pr5iomrintoasnadmptlhiengt,estthceonftlaoiwnerartsesolfigahilytthreodugihn tohredesratmoplreeldeatseset"cConOt;aipnreerssenwtaisn itnhceraerassepdafcoer in the soil bulk so that it could be trapped and ot escape during further sample workup. aFtutratchheerdmotroet,htehteesfitrsctonetxatirnaecrtsi.onTsholeutrieosnul(isnege sbleulroryw)wawassulatdrdae-sdonwiictahtetdheftorra5pmpiinngasnydsttehmesn spiult 0thaetstthefotrraanpoptihnegrs5ysmtienmwwitahsthdeetaairchsetdreaanmdstsilolilruenxntirnagctitohnropurgohcteheedevodlaatsiedtersacprs.ibeOdnlbyelafotwe.r rTehqeusieresdtfeupllsmpartoervieadlnbeacleanscsea.ry to catch the still remaining "CO in the Soil bulk to obtain the 3. Descriptionof analytical procedures cFeonrtreiafcuhgestaumbpe.ledThteestsociolntwaaisnerc,ontsheeccuotimvpelleyteexalmroacutnetd otfhsroeiel wtiamsesrefmoorv3e0dmainnd wfiitlhed5i0ntmo La aacdedtiotniiolnrailleex(tArCacNt)iwoanstefror(t9/w1, vto/vt)harneedmoinncuetewsitwhi1th0050mLmLACaNciewtaontee,ra(l1l/1o,nvaiv)l,abfoorlaltoowreyd sbhyatkweor atlhe15s0uprepmm.atAafntterdeeaccahnteexdt.raTcthieonesxtterpa,cttshewesraempaldejuwsatsedcetnotr5i0fumgLedofror1500mimnLat(4A,C2N0i0wartoemra1n/d1 aexntarlayctz)edwbiyhLStCh.e respective extraction solvent mixture and aliquots of each extract were Anfeewrweaxtsrhacbtoitotnl,e twhiethr4em5nmanLt0s.o5ilMwaNsaOtrHanasnfedrrseudbjbeacctkedinttooathceontsetstanctonsttarienaerm,oaftnaicthroegden(0foar drying at room temperature. Two aliquots of the trapping solution were measured by LSC. ``TchoembAiCnNeIdwwaittehrth(e8/a1c,evtiovn)eeexxttrraaccttss,werresepeccotmibveilnye.d,Aliaqnudotsthoef AeaCcNhIwpaotoelrso(l1u/t1i,ovniwve)reextarnaactlywzaesd Pae7or2s onsoueo avanzrozz `bmyeLaSsuCr.eAdlbiyquLoStsC,offeoallcohwepdooblyscoolnucteionntrwaetrieoncieanntrioftuagreyd,evalaipqouroattsoorfatth4e0reCs.ulTtihneg scuopnecrennattraanttesd: Solution was transferred to a 2 mL volumelri flask and made up to volume with ACNIwater a(1l/i9u,olvisv).ofAltihqeuostsupweemraelamnetasmueraesdurbeyd LbSyC.LTShCe arnedmaiHnPiLnCg.soHluPtLioCn mweaassucernetmreinfutgsedwearned cexotnrdaucctteeddrafdoiroaacltivsiatmypwlaessautnlielas6t/72.D0A%T,TAfRu.rther samples were only measured if the total DcFeotrerhamnailnayastiisoronfannaodn-ecxtratctaeble rresioidfuensozn(-NeExaRi)ra,ctttahbeliderreeodssiodinulwesas ground in an analytical mil Four aliquots were combusted, the released "CO; was trapped in Oxysolve C-400 scintillator and analyzed by LSC. TIhnevteraspstfiorogfvaovlotaltoiltelosesn:were sampled together with the respective attached test container at ach sampling time except or day 0. Three aliquots of each solution were analyzed by LSC. oTfoevaecrihfyaptphlaitctahteiornadgirooauctpivwietryeinstehleecNtaedOaHndtra3psmLoriagliqnuatoelds ffrroomm etvhoelrveesdpe"cCtiOv,e NsiaxOsHamrpalpess `asnudbjeccetnetdritofupgreedcipfiotrati2onmwiinth aBta(1O3H,)0,0.0Threpmsamtoplpersecwiepriteattereattheed wfiotrhmeexdceBsasCBOas(.OHT)h;'e8n Ht:h0e `supernatants were analyzed by LSC. No significant amount of radioactivity was found in the `supernatants (1.89% TAR), confirming that the trapped radioactivity corresponded to "CO;. AVoslaumsaetcroinfdlavsekriafincdatiaocnidsitfeipe,d 4wimthL0o.f6 tmhLe rceopnrceesnetnrtaatteidveHsCaI.mpTlhoes wsearmepltersanwsfeorreremdatdooa u5pmtLo volume with water, subjected t ulrasonicalion and purged with nitrogen for 10 min n order> eSoxlpuetliontsh,e trheulseacsoendfiCrOmi,n.g Atfhtaetrwtahredsr,adinoaoctriavdiitoyacptrievviitoyus(l0y.f0o2u%nd TiAnRt)hewaNsaOdHettercatpesd iinndetehde originated from "CO. MsMaSspsweacstusreod mtoecot(nfMriSnyn)the idenity of the test tem in application solutions and sol extracts: lIadebnetliefdictaetsitonitweamsabnadsoend tohne tchalecduleatteiromninoafttihoenmooflethceulsaprecfiofrimcuilsaoelofpreompatthteerancccuaruasleedmabsystehes. aofsstihgendeedtebcytcedomipoanrsiascohnioefvetdhewirtehteEntSiIonMiSmaenadnEdStIheMSM/SM/SM.SSdtartucatwuirtehstihneptoeosltstaemmp.les were 4.Calculation of the degradation rate Kinetic analysis and calculation of DegTso and DegTs values at 20 Cforthe parent compound 4F-O{tCrUifSluKoirnoemteitchsowxoyr)bkegnrzoouipc Raeci.d 1w.eTrhee paenarlfyosrimsewdasfodlloonweinbgy tnhoen-lrienceaormmreegnrdeastsiioonnsmeotfhodtsh.e fuosrinegacthhesasmopfltwianrgeipmaec.kTahgee DCeAgKT:Eo(avnerdsiDoengT3.s6,).vaRleupelsicaatte12samCpwleerseweesrteimtaatkeednuisnitnogatchceouGnrto `approach according to FOCUS [Ref. 1]. Poiana ASFose 20232027022 I. RESULTS AND DISCUSSION A. DISTRIBUTION OF RADIOACTIVITY AND MATERIAL BALANCE "The distribution of radioactive residues is presented in Table 1 - Table 3. Wsiatmhpilnintghet2im8esd,ayexicnecupbtatfioront,heth6e dmaaysssabmapllainncgesofweLurfeac2o.m2plwehteere(>o9n0e%reTpAliRc)atoerrealacshoeildsoannldy 85% (resulting in @ mean value of 87.6%). wFiotrhtuhneuseuxatlelnydiegdhsarmadpiloianctgivaifttyerva5l6u/e5s7idnatyhse,sleocwoenrdmNaasOsHbatrlaapnpciensg swoelruetioobnsse(r2v1e.7dttoo3ge4t.h3e%r 2TA8RD)A.T.ForTheiascihndaipcpaltiecsattihoant gtrhoeulpo,wtmheasasmobuanltanocfeCs aOt 5at6/5567/5D7ADTAaTrewcaasusloewderbythlaorsstehseoofnCeOazt d#uCeO,t.o the insufficient capacity of the NaOH trapping solutions to capture the stil evolving STohiellaim1o0unt of radioactivity extracted with ACNIwater 9/1 and 1/1 (vi) and acetone from sail samples decreased from 102.7% TAR al day 010 1.3% TAR afer 28 days. Tinhceremaisneedraflriozmat0i.on1%tTo ACRO;on rdeaaych0e0d a7m2.a7x%imTuAmRofaf4t5er.52%8TdAayRs.at 6Nodna-yesx,trwahcitaeblfaellirnegsaigdauiens 1026.0 %TAR at 28 days and then further to 22.9% TAR after 57 days. dAasydsesccaruisbeedd abbyovveol,aatilseli(ghCtlOy)owleosrsemsi.neOratlhiezratvioolnatviaelsuewoefr6e6.ne6g%liTgiAbRlewaansdonbesveerrveedxacfeteerde5d7 0.04% TAR. STohiel LamUoFuAnt22of radioactivity extracted with ACNIwater 9/1 and 1/1 (v/v) and acetone from soil samples decreased from 97.4% TAR at day 010 0.7% TAR after 28 days. Tinhceremaisneedraflriozmat0i.on5%tTo ACRO;on rdeaaych0etdo a6m3.a9x%imTuAmRofaf5t0er.62%8TdAayRs.at N3odna-yesx,trwahcitlaeblfaelirnegsaigdauiens 10.29.5% TAR at 28 days and then further to 25.9% TAR ater 56 days. dAasydsesccaruisbeedd abbyovveol,aatilleig(hCtOlyx)lolwoesrsemsi.neOratlhiezratvioolnatviaelsuewoefr5e6.ne4g%liTgiAbRlewaansdonbesveerrveedxacfeteerde5d6 0.01% TAR. STohiel LamUoFuAnt24of radioactivity extracted with ACNIwater 9/1 and 1/1 (iv) and acetone from sail samples decreased from 99.4% TAR at day 010 0.6% TAR after 28 days. Tinhceremaisneedraflriozmat2i.on6%tTo ACRO;on rdeaaych0e0d a6m1.a8x%imTuAmRofaf5t4er.52%8TdAayRs.at2Nodna-yesx,trwahcitaeblfaellirnegsaigdauiens 037.8% TAR at 28 days and then further to 31.1% TAR after 56 days. Adasydsesccaruisbeedd abbyovveol,aatilseig(htClOy)lolwoesrsemsi.neOratlhiezratvioolnatviaelsuewoefr5e4.ne1g%liTgiAbRlewaansdonbesveerrveedxacfeteerde5d6 0.01% TAR. Paesor2s ar rss Table 1 DSiastnraibautaicondoofnraSdoioTaLc]ti1v0itaynadftmeoruaspapltiicoantiuonndoefr*sCo-4r-e{tsricfolnudoirtoimoentshoxy) T ac[o% TAR]aAiET So r--oe --T-- T or" Juem Te ww WS WaoonGr uowo mm | o[e Bwom ==bd omw fa = B Wmeeda wwe es | fwa aeon ||u|| oonesms WH Woooona nmamfE om moom iaorotrl 8F Bosuw onuR |lewomoo boAot Gow be bd B g oa onapas oE om Euw ceFS ne ] a a oo m0u : aosf | miae om oWmm ReF2iA nB E TTRaapmsE a o Ea l onssensei in as ar mrss Table 2 Senza acon sot LUFA Distribution of radioactivity 3aftaenrdapwpleiscpataitoononfun"dC-e4-s{etrroifluocroonmdeitthiooxnys) T rc[ona"%oTARo]lAnnEi r-- oT r. ---- B Win obomewe f|ae o=oam wr HS n wDahmm h | oom+ | om MBBmooe onnormomlEEEooaos Sa woooamoa onu|rn wm ion Pewo3e a B Wooa da soa nn a |loe me ooooeee m | oPasRem | owe aG a eoe e ln oa oema ws wmae ee lmw|e ||omow F6G G o ae 5--a --eaoi |-- -- mE lae -- moemmail BaesA fCnB E pTETatapymsa--E oA r SeE e T atom tein rs