Document jm2xkzZGgXnYyDm7BvrG94D2N

FILE NAME: Phenolic Resins (PHR) DATE: 1945 Nov 16 DOC#: PHR033 DOCUMENT DESCRIPTION: Meeting Minutes - American Petroleum Institute Medical Advisory Committee Fcr Info:r a t i o n Only - Not For Publication A F R I C A N PLTRC'LLUM INSTITUTE LEDICAL ADVISORY COMMITTEE Minutes of Meeting Novenfcer 16, 1945 Stevens Hotel Chicago, Illinois Tt'BSRS ?!-T.SCiHT' 'V. o. Armstrong V. C. 3aird F. F. Boys UF,TREES ABSENT i D. ii.English H. A. Jewett ASSOCIATES PRESENT: E. v;. Adams L. C. Beard, Jr. R. S. Bonsib elver N'oody - Chairman D. V. Stroop - Secretary T. li. Frank A. E. Hoag J. P. Holt M. N. Newquist B. B. Reeve 0. S. Somerville (Rep.. by M.. Erooks V/. R. Levis A. Morrison J. F. Feattie * * H.'S. Thomson K. C. Cole Nelson J. Cothard H. P. Lankelraa H. K. Aarrick F. ii. Matkins Robert .... Fenoe, II.D. - Kettering Laboratory, University of Cincinnati. I ..JNUTSS OF PREVIOUS ..LISTING Action: The minutes of the meeting held i!ay 7-8, 1945 at St. Louis were approved as circularized. II REPORTS OF SUBCOMMITTEE C H A I K I N Subcommittee on Carcinogenicity - M. N. Newq'iist, Chairman. Dr. Newquist presented a formal report with outline of proposed research project and copy of the form of agreement required by the University of Cincinnati in its toxicity investigations. (See Appendix A to these minutes.) API 06773 -2- j r . yihoe :-.nd the members discussed in detail the report, the outline of work, and tnc lore, of agreement. Acticn: 1. Tlic report of the c n a i m a n was accepted 2. It was agreed unanimously that the type of agreement required by the University of Cincinnati should be signed, if necessary, in order th^t the Uedical advisory Committee may promntly nrogress the selection of a suitable investigator. 3 . It was agreed unanimously that the Kettering Laboratory of Applied Physiology should be selected to initiate the investigation on carcinogenicity as outlined by the subcommittee. 4. It was agreed unanimously that the matter of selecting samples for the investigation should be referred back to the Subcommittee on Carcinogenicity with power. B Subcommittee on Chlorinated Compounds - F. F. 5oys, Chairman. Dr. 3oys presented a formal report which was discussed at length by those present. (See Appendix B to these minutes.) Action: 1 . V.'ith slight amendments, the report was accepted. 2, The secretary was requested to transmit copies of the report to directors of the American Petroleum Institute with the suggestion that the report may be of interest to medical, legal, and cutting oil sales departments. C - Subcommittee on Permissible C o n c e n t r a t i o n s V. C. 3aird, Chairman. Dr. 3aird presented a formal report, a copy of which is attached as Appendix C to these minutes. action: 1. 7,'ith a few additions to the lists of industrial toxic materials, the report was accepted. 2. The secretary was requested to send duplicate copies of the list of industrial toxic materials to all members and associates and to ask them to return one copy upon which the listed materials, and any additional materials, are classified into three groups so ns to indicate three degrees of need for prompt publication of data. Subcommittee on Ijedicrl Policies ;nd Practices - R. A. Jewett, Chairman. In the absence of Dr. Jewett, the subcommittee report was presented by Dr. Frank. (See ppendix D to these minutes.) API 06774 -3- ction: ! Th: reoort cf the Subcommittee on Medicol Policies '.nd Pr--ctic.s -,,as accepted v/ith expressions of appreciation for the splendid service conaributed by Dr. Jewett. . I 2 . The chairman tens asked to make additional appointments to thc- mtr.bershdp of the subcommittee to replace those who have indicated their inability to serve. Ill 3UDj3TS FOR 1946 CGli.ITTZZ .CTI7ITI5S ..cticn: Daring the meeting, 1946 budgets were established and funds were allocated for activities as follows: (h ) .t budget was established and ,>,500 of the Medical Research Fund were allocated to initiate the library research on permissible concentrations, as recommended by the Subcommittee on Permissible Concentrations. (3) I-, budget was established and .-{6,000 of `the 'Medical Research Fund were allocated to initiate the investigation to be conducted by thu Kettering Laboratory. (C) r,n unspecified amount of the Medical Research Fund was authorized for expenditure in the purchase of a library of 10 authoritative books on toxicology and a suitable shipping case so that arrangements could be made to have such books available at future meetings of the Medical Advisory Committee. IV CH-.:.'1S IN CCAMITTZ C.iC.J.TZ,.TICN-.I'D PKC-CADUAL ^ ..ction: 1 The committee regretfully accepted the resignation of Doctor I. 2. P>~rcy. 2. The members agreed unanimously that Dr. Moody should continue as chuim-ji during 1946. 3. The chairman was requested to consider and to make several changes in subcommittee memberships. (These will be announced in the near future.) 4. Chairmen of subcommittees were requested to prepare their reports at the earliest practicable date so that copies may be circularized in advance of each meeting. Note by Secretary: Such prior circularization will be done by ..PI !>Ieadquartors for rooorts received not later than 30 days prior to a meeting. 5. The secretary was requested to circularize copies of a revised list of memoirs and associates complete with F.C. addresses. API 06775 Dr. Hr-ifj retd memorandum dated November 2, 1945 from Janes T. Beard, Jr. as follows: "The resort of the Subcommittee on Chlorinated Compounds of the ,,pi Medical Advisory Committee, dated October 16, should be of interest to all marketers of cutting fluids. We feel that it is an important step in calling attention to the possible effects of various types of chlorinated materials. Vie are quite in agree ment with the conclusions that have been reached. "We are now suggesting that other phases of this problem are worthy of investigation -- namely, those phases that deal v.'ith bacteria, the effects of bacteria on operators, and the control of bacteria in all types of cutting fluids. Vie suggest the following line of investigation (a) An investigation of the various types o f bacteria found in used cutting fluids, both non-soluble and soluble -- th- pathogenic groups, and the faculta tive anaerobic groups; (b) The rate of growth of the various bacteria in various types of fluids -- (* 1. Mineral oil i 2 . Mineral oil and fat > 3. Mineral oil and sulphurized fat t 4. Sulphurized mineral oil I 5. Sulphurized mineral oil and fat 6 . Sulphurized mineral oil-- and sulphurized fat 7. Mineral oil and chlorine 8. Sulphurized mineral oils and chlorine 9. Soluble oils and soft water 10. Soluble oils and hard water (c) The effectiveness of various germicides on the various groups of bacteria, and the percentages required to keep cutting fluids sterile. "This is an extensive program, and it may not be practical, or even possible, to carry out in its entirety. However, any steps that can be taken to enlighten us and the general public along these lines will be very beneficial." Action: The subject was referred to the Subcommittee on Chlorinated Compounds for study. VI ..SA crarJTTTSE ON TOXIC DUSTS ,iND G.lSES (ZT7) API 06776 The secretary requested the committee to nominate a member and an alternate to serve as API representatives on Committee Z37. -5- nCtion: The committee nominated Dr. V.'oody :*.nd ilr. Bor.sib ns the member m d alternate, respectively. V II ::zxt h z t h ,cticn: It was agreed that the next meeting should be held in Cidcngo cn Monday, April 8, 1946, which is the first day cf the 1946 meeting of the ,imerican Association of Industrial Physicians and Surgeons. VIII ADJCUR&1ZNT As there was no further business to con before the meeting, it was adjourned. Approved elver '.ioody Chairman D. V. S tr c o p S e c re ta ry Becember 3 . 19*15 API 06777 fplkdix a For Information Only - Not For Publication t.-TPORT OF sira rrw rT T S E ON CARCINO'SNICITY TO: DR. MclVER 'fOODY MAH. EPICAL ADVISORY COMMITTEE - aPI On .uvust 13, 1945, a marting of the S u b c o - i U . . on Carcinogenicity called in New York. Those who attended were: Dr. M. N. Newquist Dr. A. E. Hoag Dr. I. E. Percy Dr. Mclver V/oody R. S. Bonsib L. C. Beard H. R. 'Jarrick D. V. Stroop Dr. R. A. Kehoe (guest) At tide nesting, the objectives and procedure for study of carcino genic Properties t o ^ t K ' sLj! T e h f e S . 2 S to b e l n t S S t e d in cubing the study, but he wished to consider it*further before coming to a conclusion. In a letter to Mr. Stroop dated August 28, 1945, that ne wished to ^ " ^ U r i f W before P ^ " y TM s lo ii'c i i ^ S l 'f S S r S agreement font attached), and (2) He .ished to have a clelreJ S d S s t L n d l i s of the particular problem in question. since there as a difference of opinion among members of the Subcommittee a f S whether the contract should be signed i^n the -bmltted by =r. Kehoe, a meeting o | [ ^ S u b c o n m i t t e e ^ e r s ^ Ne,, 'lortc Hosg, Adams, Beard, Na tentative selection of petroleum products to be for further discussion, anu for a tentative seie -ortrnct still existed studied. The difference of opinion with respect to the r.trnxt still Ft the close of this meeting, so Mr. Stroop was ~ ^ e d t write ^ further clarification of certain phases of the proposed contra . b"ifr. Stroop on September 25, 1945 - which included an invitation to Dr. Kehoe to attend the meeting of the Medical ndvisory Committee m Chicago on November 16, 1945. In a letter to Mr. Stroop dated October 13, 1^45, Dr. Kehoe advises to the effect that the Kettering Laboratory could not undertake J TOa proposed study unless the contract submitted by the U m v e r s i y his signed by the American Petroleum Institute. Dr. Kehoe may vas o p position personally at the meeting on iJovember 16th* Since the signing of the proposed contract involves a matter of policy of the API, it is suggested that the recommendation of the Ledicai .-.dvisory Coianittec of the API be obtained in this connection oefore pr o c e e u n g further. API 06778 -4t~ Respectfully subrrdtted, Dr. 1. W. N'ewquist, Chairman . November 16, 194$ Demurs: . Dr. 4. N. Newquist Dr. / E* Hocg j)r . Joseph ? Holt Dr. I. E. P=rcy Dr. Dir.. h. Levis 4 r. H. R. Warrick Mr. L. C. Beard iiir. Roy S. Bonsib Mr. H. E. Keranerer API 06779 F yyy>.D a55I-5CH FRCJICT 0f study of Carcinogenic Properties of Hydrocarbons > _ i.-mediate -- To study carcinogenic properties of those petroleum products ' '..hich, on the basis of present knowledge, are most likely to embody such dualities, (diesel oil, furnace oil, heavy fuel oil, road oils, asphalt and coke) and with which refinery employes and the public are nest likely z c cone into contact, so that any indicated precautionary ineas'ires may be instituted 5 - Future -- To study pure hydrocarbons contained in petroleum products in an effort to determine the presence or absence of specific carcinogenic factors. a '.cedure > - It is proposed that a centralized laboratory adequately staffed and equipped (portions of the study may be assigned to other acceptable rus-arch institutions) conduct appropriate studies in line with the objectives stated above, which would include:v 1. Literature survey of the carcinogenicity of bituminous compounds to date. 2. Examination of samples of petroleum products* which will be submitted at the direction of the liedical advisory Committee, these samples to be subjected to both analytical and animal testing in order to determine their possible carcinogenic properties. It is proposed that these samples be drawn from representative thermal and catalytic ere eking operations, using a wide range of crudes and operating conditions. Control tests will also be run using known similar carcinogens, 3* The develoDment, concurrently and"based upon the above testing of samples, of a chemical and/or physical test which will determine the carcinogenicity of a given material without the necessity of conducting animal tests. b . The development of a means or a method by which the carcinogenic properties of the petroleum product concerned may be neutralized. 3 - Although the incidence cf cancer among petroleum workers is not unfavorable as compeared to that cf the general population, it is proposed, nevertheless, to request information from the medical departments of those conpitnies rnving adequate records, as to the incidence of cancer among their respec tive employes which was ascribed to their occupation (1 ) in the past, and () in the future. D '"i jstic He. 2 Fuel Oils i. Straight run b. Thermal Recycle c. Houdry or TCC Recycle (i. Fluid Recycle 2. Heavy Fuel Oils a. Straight Residual b. Thermal Tars c. Houdry or TCC Tars d. Fluid Tars API 06780 fl fi P ~ X TEIS AG5ESM3TT Made - ' ' A (hereinafter called: (hereinafter called: , between - " the Donor"), and the TOIYEHSITT OF CINCINNATI, "the University") WITNESSETH __ -: c-;TVl >- UEZ3EAS, 4 r.< fA - -*^ VtT'.-JufJw J n" wish the Kettering Laboratory of Applied Physiology (hereinafter called: "the Laboratory") to investigate the toxicity and node of action of certain eh eaioal pc.-rr-.^-1'"r^ products to be mutually agreed upon hereafter from time to time; and WHEA2EAS, the University has approved such investigative wots: * V v by said Laboratory, In consideration of tho mutual promises hereinafter specified, IT IS a g h e e d : , X* 1 . The Laboratory shall carry out such investigations v.'ithin I the limits of its available facilities and scientific interests. 2 . Tho Doner shall pay the University therefor the sum of S it poLUfyg.S on -or beforo / " 1 and additional sums in advanco from time to time as may nitually be agreed upon as necessary to prosecute projected experimental work for a definite period of time. At the end of each fiscal year or other period agreed upon for tho completion of a spocific projoct, tho University shall refund to the Donor any unexpended balance of any payment remaining aftor the investigp.tivo work has been completed, or shall apply the balanco to the continuance of such similar work as nay be agreed upon as desirable. 3. The name of the University or of the Laboratory or*of any nonber, officer or employee of the University or the Laboratory, API 06781 c o f r (seiVtiatted) - 2- shell not be used, in any advertising natter at any tine daring the progress cf the work or thereafter. A written report shall be made of the findings and such e report or a photostatic copy therof nay be used by the Dcnor as evidence of the facts established. If the findings are published in a scientific Journal, the Donor shall be free to quote such findings subsequent to publication. 4 The investigative work shall bo planned and carried out by the University, and the University shall have the right to disseni., nato for the public good, any information o b t a i n e d Howovor, before the issuance cf public reports or scientific publications, the . manuscripts thereof will be submitted to the Donor for criticism and suggestion. 5. Do person shall be roquirod to make an applicati~n for patent based cn any invention, diaccvory or development resulting from any investigative work under this Agreement. IN WITNESS WHEHEOy the parties horoto have executed this Agreement by tneir proper officer, respectively, who ore hereby certified to havo been duly authorised to execute tho same. A m e c #h IwiTnvre -- -- -- -- ---------------------' --i ay. UNIVERSITY OF CINCINNATI through its BOARD 07 DIRECTORS By Chairnan By Clork API 06782 APF5.DIX B For Information Only - Hot For Publication REPORT OF 5UI3C01iiITTEE ON CHLORINATED COMPOUNDS API LEPIC,J- nDVISORY COLliITTSE IKE PhOPLSi Cutting oils containing several percent of Chlorinated Compounds have been used in industry. The compounds used have been Chlorinated Paraffin, Chlorinated Naphthalene, Chlorinated Diphenyl and Chlorinated Diphenyl Oxide. These compounds have been employed to improve the finish of the work and to inerease tool life* There have been certain objections both real and theoreti cal tc the use of such compounds from the standpoint of the health of the workers. This has been particularly true in the case of the Chlorinated Aromatics. A, Systematic Effects - There have been fatal accidents from the use of Chlorinated aromatics in the coating of electrical cables when drawn through Chlorinated Aromatics such as the Chlorinated Napht*hlen'fe. In these cases, large quantities of the Chlorinated Aromatics were held at elevated temperatures and as a consequence material percentages of the product vaporized and establish ed toxic concentrations in the atmosphere. Frequently ventilation was poor. ;.s a result, inhalation of the product occurred nnd was in a few cases followed by systemic effects, notably acute yellow atrophy of the liver. This history naturally has made the use of Chlorinated romatics suspect. B. Dermatological Effects - Denaatosis from cutting oils, containing only petroleum hydrocarbons, is not unusual when conditions of uncloanliness obtain and when the workers are allergic to petroleum hydrocarbons. More recently recognition has been given, especially by Dr. Louis Schwartz of the U. S. Public Hoalth Service, to a specific type of dermatosis which he has named Chlcracne. Dr. Schwartz has published several -papers on this subject. The investigations were said to deal with the Chlorinated Aromatics. The problem of the Subconsnittee was to evaluate the importance of both the systemic and dennatolcgical effects of Chlorinated Compounds as related to the health of the workers using cutting oils containing then. REVIEW OF LITERATURE ND ACCUMULATION OF DAT,. FROM INDUSTRY As the quickest approach to obtaining such information as was available either in the literature or in the files of industrial companies, a questionnaire was sent to two manufacturers of Chlorinated Paraffins, to a manufacturer cf Chlorinated Naphthalenes, to a manufacturer of Chlorinated Diphenyls and to a manufacturer cf Diphenyl Oxides. These companies were the outstanding manufac turers and marketers of such products. They were requested to supply any data or the results of any physiological investigations they had on: 1. Dermatological effects cf the compounds made by them. 2- 4. Brief statement as to any serious cases cf dermatosis cr systemic pciscning. 5, -That laboratories or institutes they ccnsidered most skilled in conducting investigations of the toxicity cf such compounds as related to their industrial uses. The response tc this questionnaire was unanimous, cooperative, and unbirssd. The consensus was that the Chlorinated ^romatics could and did cause serious systemic pciscning, as well as dermatosis, especially under conditions cf peer ventilation and poor hygiene. The Chlorinated Paraffins cn the other n- nd s-er.i tc be relatively free cf these objections. One company reported, "In all cur experience we have been unable tc lccrn cf any evidence that Chlorinated Paraffin ./ax has either aermatolcgical cr~systenic toxic effects." The other company, quoting the results of a physiological laboratory, said, "These results show that the Chlorinated paraffins made by our processes were not toxic under the condition cf test and did net cause dermatitis." They stated that they had confidence in the laboratory making the tests for them, but they could net guarantee their findings and that it would be necessary for each user to make their own toxicity and dermatosis studies cn the particular combinations t h a t 4they might use. A literature reference on Page 420 of the "Rubber age" August 1943 states, "A. G. Cranch in a recent personal communication tc one of the authors, stated that the effect of these waxes cn the skin resulting in the appearance c f . acne is net determined by the presence cf chlorine alone, but is due rather to J the compound effect of chlorine and a tar derivative* No such marked tendency to acne formation results from exposure to chlorinated petroleum derivatives, such as Chlorinated Paraffin." EXPERIMENTAL The information given above showed that iry relatively high concentra tions the Chlorinated Aromatics can be harmful. It was felt desirable, therefore, to determine the order of concentrations which might occur in the atmosphere in the locality cf metal grinding and cutting work. To this end three experimental cutting oils were compounded containing Chlorinated Paraffin, Chlorinated Naphthalene, and Chlorinated Diphenyl. The total chlorine content of each of these oils was 3%, equivalent to approximately 6% of the Chlorinated Compounds. Use was made cf a Earner and Swasey turret lathe and a Cincinnati Cylindrical Grinder. These tools were first operated under normal conditions cf feeds end speeds and secondly, with heavier cuts and reduced oil flow in order to induce smoking, analyses were made of the chlorine content of the r.ir at distances cf from 16 to 60 inches from the cutting edge. The concentrations of chlorine found ranged from none to 0*55 milligrams per cubic neter of air. The concentration of Chlorinated Compounds were approximately double this amount since the Clilcrinated Compounds used contained roughly 50$ cf chlorine. The above tests wore conducted in the Technical Service Laboratories of the Socony-Vacuum Oil Co., Inc. and the Carbide and Carbon Chemicals Company assisted in obtaining the analyses. A member of the API Medical Committee m s present during the tests. API 06784 Comparison of the concentrations obtained with the oermissible limits reported by Dr. C. K. Drinker (J. cf Ind. Hyg. and Tex., Vcl.*21, 1939, p. 157) shows that in general the concentrations obtained were well below his permissible limits, which ranged from 0.5 tc 10.0 milligrams per cubic meter. In seme cases drinker's permissible limit was exceeded. In a private communication, however, the members cf the committee, Drinker stated that his limits are predicated cn eight hours per day continuous inhalation. Drinker further stated that he felt it unlikely that in cutting operations a sufficiently high concentration would iccur to cause systenic effects. PERSON,'!, c o n t a c t s Several of the companies replying recoimended Dr. C. K. Drinker cf Harvard School cf Puhlic Health as an outstanding authority on this subject. On September 26, 1945 Dr. Drinker met with the New York members cf the Subcommittee cn Chlorinated Compounds, As stated above, Dr. Drinker expressed no concern regarding systemic effects when Chlorinated Compounds were used in cutting oils because he felt the concentrations were nc>t sufficiently high. He did, however, sound a warning tc the effect that since Chlorinated Aromatics had under more rigorous conditions of use caused yellow atrophy cf the liver, any case of yellow atrophy of the liver, whether rightly attributable to the cutting ail '.r net, would be so construed. This points tc the need for careful medical examination cf employees or prospective employees using* chlorinated cutting oils for liver damage. Additionally, for much the same reasons, workers with adolescent acne or a predisposition to acne as well as these with skin allergies should be excluded from such work. He further mentioned that workers subject tc treatment with arsphenaraine and the like should be barred. Ccnmenting cn the Chlorinated paraffins, Dr. Drinker said that in animal experiments he had administered enormous amounts cf Chlorinated Paraffin without the occurrence of yellow atrophy of the liver. Ccramentihg on the dermatological aspects, Dr. Drinker felt that it would be a waste cf money to investigate this phase further. For a competent investigation, there would be a need for human volunteers, who are unlikely tc be forthcoming. In the absence of these, clinical observations of workers in industry using cutting oils containing chlorinated compounds might supply useful information. It was suggested that consultations be had dth the heads of the Departments cf Industrial Hygiene of seme of the states. Dr. Leonard Greenburg cf tnc New York State Departrrent of Industrial Hygiene was suggested in this respect; such consultation was had and a letter from him is attached. CONCLUSIONS nil the above leads to the following conclusions: 1. Chlorinated Paraffins appear to be relatively free firm condemnation aue tc either systemic cr dematclogical effects. . The likelihood cf systemic effects by the use cf chlorinated aromatics in cutting oils is remote. There are claims in the literature of adverse dermatological effects. 3. Suitable precautions should be taken in the selection of workers, one vcrking eenditiens and hygiene. The toxicity cf carbon tetrachloride is well recognized and there fore should net be used as a cutting oil additive. This report should be viewed as preliminary and work is continuing. November lo, 1945 API 06785 DIVISION o f nfljosflOAi h t g i f t b jlJIP S JJT H standards DEPARTMENT OF smcusi 2M So. W orr.il Si. IU FFALO S lo t O ffice >14. LABOR I'NGM AM TON SQ2 P in t Hog NOT York City, IS November 7, 1945 j r . A. X. Hoag Medical Department Socony-Vaeuum oil Co. 26 Broadway New York City, N. T. Dear Sr. Hoag: *0 hare read orar the draft of the report of your sub~ccmlttee on chlorinated compound* of the A.F.I. Midi cal Advisory CcMlttee, pre pared by you and Dr. Beard and dated Ootober 16, 1945. With reference to this report, I would like to say that we bellere the use of chlorinated paraffins to bo relatlTsly free of hazard and essentially we agree with your first conclusion, with reference to the use of chlorinated aromatic compounds la cutting oils, we bells t s there Is a very real possibility and eren likelihood of producing dexvatitis and that the incidence of this nay be quite bi particularly with long, continued exposures, with reference to systemic poisoning, we believe the possibility to be far sere remote but, nevertheless, we feel that Industry should be fully warned as to such a possibility and instructed Just how to utilize precautionary measures. I trust this answers your purpose but should any further questions arise, please do not hesitate to call on m . IN REPLY P LEA SE ADDRESS W RITER API 06786 For Information Only - Hot For Publication EFFORT OF SZC0I1IITTEI FOR PZPUSSIBLL COXEKTR/.TIONS CF TOXIC SU3STAKCES IN THE PETROLI7J-J INDUSTRY We have outlined the scope of our assignment as follows: 1. To prepare a list of the toxic substances used and produced in the petroleum industry. 2. To collect and publish information on those substances in the above list v/hose toxicology has already been established. 3. To select those of the subjects remaining on the above list which are of sufficient and general importance and on which satisfactory toxicological information has not been determined, and to develop a research program for their study. We have prepared a tentative list of the toxid Substances used in the petroleum industry, llany of the compounds are listed by type only, thus eliminating in this list an enormous number of possible homologs, for example, "naphthas," "mercaptans," and "phenolic homologs." 1 copy of this tentative list is attached. v,'e propose to develop the following information in connection with the second objective listed above: I. Marne of substance II. Properties and Characteristics - Physical and Chemical III. Uses in Petroleum Industry , IV. Toxicology a. Acute effects, including symptoms b. Chronic effects c. Safe limits V. Treatment VI. Examinations - a. Preplacement Examination b. Periodic heexami nation 1. Frequency 2. Extent VII. Safety Precautions a. Working Rules b. Equipment VIII, Bibliography API 06787 To prepare this information, we have entered into negotiations with 9r. Cecil K. Drinker, Professor of Physiology and head of the School of Public Health cf Harvard University. Dr. Drinker has agreed to undertake this assign ment. ijuch of the library and research work will be dene by a graduate student,