Document jgbknOmrXgedkDJqz3gn3Qn32

BCC: Mr. lie Smith - 0.0. August 9, 1961 Mr. D. B. Bowser American Cyanamld Company Willow Island, West Virginia Dear Mr. Bowsert Mr. MoKinnsy of our Cincinnati office has asked me to send you toxicity and safe handling information for our produot Pydraul AC. Animal toxicity screening studies with Pydraul AC indicate that the oral lathal dose to rats is greater than 92.0 grams per kilogram. In the case of rabbits, the minimum lethal dose was found to be 3>5 to 4.5 grams per kilogram. The difference in toxiolty to various snlmal species is not unusual in the oase of our hydraulic fluids. Based on the lethal dose in rabbits, we conalude that Pydraul AC may be considered only "slightly toxio" from the standpoint of accidental ingestion of single doses. Whan applied to the unbroken skin of rabbits, the skin pene tration lethal dose was found to be between 4.0 to 5.0 grams per kilogram. Again, this indicates a relatively low order of toxicity in terms of accidental exposure to large areas of the skin surface. Skin and eye irritation potential studies in animals lndloate that irritation is not a serious hasard. We do reoassnend, however, that prolonged and repeated skin contact be avoided. In relation to eye irritation, animal etudiee do not reflect the pain which has been reported when the fluid has accidentally splashed in the eyes of workers. Significant pain and moderate irritation have resulted in the case of suoh acci dents. As would be predicted from experience in animals, no permanent damage to eye tissues or to sight has resulted. Rats survived six-hours' continuous exposure to an atmosphere saturated with vapors of Pydraul AC. This Indicates that aooldental exposure to massive vapor concentrations presents no serious acuta hasard. MCNS 091059 Mr. B. B. Bowser August 9, 1961 Page 2 We believe that any Pydraul AC carried over In compressed air or gases presents no significant toxicity hazard to humans breathing the air or gas. The limited series of samples taken from a compressed air line used for such purposes indicated that no measurable quantities of the components of the fluid were present. Certainly, single or limited repeated inhalation exposures cause no effect In Industrial uses of compressed air where workers are provided with protective alr-supplled respira tory equipment. Any Pydraul AC vapors In concentrations to be toxlcologlcally significant would be objectionable from the standpoint of odor. Even these concentrations would not be significant in terms of possible toxic effects unless the workers were continuously exposed eight hours a day, week after week, during their working hours. Where the compressed air is supplied to workmen through indivi dual alr-supplled respiratory masks, good Industrial practice dictates that the system include an alr-llne filter. Such a filter Is available from the Mine Safety Appliances Company and will remove organic vapors, odors, oil, water mists, and condensation from the compressed air. If I can be of any further assistance, please let ms know. Very truly yours. REKiPH CCi Mr. (Jordon McKinney R. Emmet Kelly, M. 0. Medical Director MOAS 091000