Document jgVY8qXer5k89kwrRXyD0q782

FILE NAME: Oil Industry and American Petroleum Institute (API) DATE: 1955-1957 DOC#: API191 DOCUMENT DESCRIPTION: API History of the Subcommittee on Carcinogenicity API * HISTORY OP THE SUBCOMMITTEE ON CARCINOGENICITY 1955-1957 API 06031 r 4 1 THE STANDARD OIL COMPANY I April 15, 1955 Dr. R. ?.. "cV ardt, T lr* cto r V?gadnolcaRl*sRo.srochar&ch^Dnigviinsoi*ornlng Co. Lindo^no,x 5i Jorsoy at OhCfCUVP.ATCI.'HAuLspCoArI, CMSl.9U. ltJBB Do*r Dr. c'-artti . I rf*M ne to our joooat oim ?oad*aM n p r * li{ tbs cblooraoLoagutbwjooo(t1)taddoopuiora tsolfoptbhoias s aorot laerlaarabaytioDnr. oSf utaopdaary* iItraib u*to-d March 9 , 1955 Corartr^nt by Zt o. nonbors o f tho HTA T iro sad Aeel-iowt r r o * tlo s H. F o llia o f tho l a t lo c a l F o tro lo v s A ssociat lo a in Washington. Fory truly *twr*, JwOiaad Zoo. (2) CCt Dr, Goerfo M. 8aundors Hr. D> 9. 3troop J. . Osborn, M.D. k API 06062 Pr 1 OCCUPATIONAL CANCER HAZARDS W. C. Hueper, M.D., National Cancer Institute (The article reprinted herewith was prepared for the March-April, 1955 issue 0f "safety Standards" a publication of the U. S. Department of Lahor.) The rapid development of modern industrialism has been associated with the appear ance of many new occupational health hazards of which those causing cancers occupy an important position. The term "occupational cancer" is applied to malignant tumors originating in in dividuals during the course, and/or as the result of the regular and usually prolonged exercise of certain occupational activities entailing contact with some exogenous, physical, chemical or parasitic agent acting in proper intensity. Occupational can cers thus are caused by specific agents or etiologically related to well-defined occupational conditions which form an integral part of the ordinary working environ ment. They differ through these aspects from the accidental occupational cancers which result from or follow upon some extraordinary, unforeseen, accidental injury sustained at work and being of a nonspecific nature. Types and Nature of Occupational Carcinogens -9 Occupational agents which are known or strongly suspected as having caused cance: of various organs in workers who became exposed to them are largely chemicals. Some of these chemicals are well defined (arsenicals, chromium compounds, nickel, asbesto benzidine, beta-naphthylamine, L-aminodiphenyl, benzol), others consist of variable mixtures -of a large number of chemical compounds, a few of which possess carcinogeni properties and some of which have been identified (soot, coal tar, pitch, bitumen, tar oils, creosote oil, anthracine oil, lamp black, lignite tar and crude paraffin oil; shale oil and various petroleum fractions (industrial fuel oils, diesel oils, lubricating oils, cutting oils, crude paraffin oils, petroleum tars, pitches, asphalt and coke), and crude isopropyl liquor produced in the manufacture of isopropyl alcohol). A second group of occupational carcinogens is composed of agents characterized by their ionizing and nonionizing radiation (x-radiation, radioactive substances, ultra violet radiation). The third group is represented by environmental agents and condi tions which sometimes have an occupational association, and which may be related to certain infections (schistosoma hematobium) or several specific climatic, geologic, dietary, and nutritional conditions, and which in part have a more or less indirect relation to carcinogenesis (malnutrition with protein and vitamin B-complex deficiency). In addition to these established occupational carcinogens there are a number of potential human carcinogens which have been shown to elicit cancers in experimental animals and to which workers become exposed 'during their regular occupational activi ties (synthetic estrogens, chlorinated aliphatic hydrocarbons, methylated naphtha lenes, diethylene glycol, p-thiourea, thio-acetamide, light green SF, brilliant blue FCF, fast green FCF, butter yellow, beryllium, selenium, cobalt, and various polymer ized plastics). These potential agents also must be considered in the adjudication of compensation claims. Evaluation cf Evidence API 06063 For the establishment of casual relations between ar. exposure tc these agents and the subsequent development cf a cancer of an occupational renesis and therefore com- NATIONAL PETROLEUM ASSOCIATION ras 55-3 MTCm L MW m m Cual MULO C.`Mit MNCUIICMM i.i.ruu< DUiti t.ntaci March 9, 1955 TO: MBMBEh HPA FIRE AND ACCIDEtTOTPREVEHTICR DEPARTMENT In comparatively recenVvears, racer hazards in industry have been recognized as of increasing importai le and nagnitude. Several organizations are devoting considerable study te problem and health authorities in many k J c H large cities are watching the siti Lon very closely in the areas of their M iU lx . Jurisdiction so that necessary n/les id regulations nay be enacted if, in their opinion, they become necjcsary f o ^ t h e safety of workers. Because certain petroleum products o X m t e r i a l s produced in the re- 1 l fining of crude oil are among those listed m a occupational carcinogens, a recent article a p p e a r i n g in the Mardh-Aprll^^955 issue of "Safety Standard 7 a booklet published b y the Bureau of Labor S t a n o ^ d s of the United States Department of Labor,shwid be of particular intei\st to all those concerned with the protection a y safety of workers. The article referred to in "Safety Standards" titled, "Occupational Cancer H a z a ^ s " by Dr. W. C. Hueper, fern ) Brr M.D. of the HationayCancer Institute, is, in our opinion,of Sufficient importance for us t c reproduce it for your information f i l e . A copy of Dr. Hueper's article as it appeared in "Safety Standards" re attached hereto. API 06064 f^ 2 *> i Definite evidence oust be available Indicating that the claiaant had occupational *' t with any one of the various agents listed; that this contact vas either of pro nature extending as a rule over periods of at least 6 months ; and vas of adequate lty for eliciting a cancerous response, according to any previous experience vhlch be available on this point. Single exposures may be considered to be effective if g,e causal agent consists of external ionizing radiation or the-exposure mechanism favors bostporrogdauncitsimon of aenscuaer.cinogenic depot in the tissues from vhieh a prolonged exposure of the I b. The route of exposure to or introduction of the carcinogenic agent in addition its specific chemical properties and metabolic peculiarities determine the site of organ or tissues in vhieh a cancer is elicited. Therefore, not any cancer, but cancers of specific sites are related to any particular carcinogenic agent. c. The type of exposure does not need to he continuous or extend up to the time of pearaoce of the cancer, but may be intermittent. In fact, any contact with the occu- ^gtional carcinogenic agent may have ceased many months to years, or occasionally, even decades before the cancer becomes manifest. Effective carcinogenic exposures may be gufitained not only by the ordinary operators employed in operations vltb occupational carcinogenic hazards, but also by workers entering such operations on a transitory basis, gueh as supervisors, maintenance personnel, repairmen, truckers, loaders, yardmen, and yorkers employed in rooms and buildings near the hazardous operations, if housekeeping gad exhaust disposal methods are inadequate and environmental contaminations result. d. Occupational Medical Stigmata-- Por the establishment of cannai relations between occupational exposures to carcinogens and subsequently appearing cancers, it is of dis tinct value to analyze the medical history of affected persons for functional or anatomic disease manifestations characteristic of a pathogenic action of the particular carcinogen allegedly involved. Such nomcancerous and often preparatory or precancerous symtoma of etlologic specificity act as stigmata or biologic fingerprints supporting not only the actuality of a previously sustained specific exposure, but almo its causal relationship to the cancer present. Symptomatic manifestations possessing such s significance are, for instance, chronic radiodermatitis, chronic tar dermatitis, arsenic dermatosis, chronic solar dermatitis, chronic radiation periostitis, ashestosls of the lung and leukesoid reactions after exposure to benzol and ionizing radiation. Chemical analyses of tissues far the incriminated chemical also may sometimes help in establishing previous contact with any specific occupational carcinogens, such as arsenic, chromium, nickel, radioactive substances, and benzol. It is important, however, to note that these procedures are not applicable for all occupational cancers. Same carcinogens do not produce any etiologically characteristic (Tiptons; in fact, they may not elicit any preliminary toxic or other disease phenomena despite a persistent and prolonged carcinogenic exposure. Thus, cancers of the bladder in dye and rubber workers may develop in the absence of any preliminary local or general wrning symptoms after more than one or two decades of continuous, intermittent, or discontinued exposure to certain carcinogenic aromatic amines. There also does not exist any parallelism between the toxic and/or irritative properties of any chemical and Its potential carcinogenic qualities, nor, is there a relationship between the degree of toxicity of any particular carcinogen and its relative carcinogenic potency. e. Extensive experience with occupational cancers indicates that there usually elapses d latent period of years, if not decades, between the onset of exposures to e carcinogenic gent and the appearance of the resulting cancer. It la for this reason most unlikely that occupational cancers became manifest within the first year following the inception of con- with a carcinogenic agent. In fact, all cancers which make their appearance during first three years of occupation in a carcinogenic environment should be subjected to grere scrutiny for a more probable nonoccupational origin before they may be considered an occupational viewpoint. API 06065 ? - if - / The relative effectiveness of any medical, sanitary and technologic control meamres to je adopted can best be determined by ascertaining the changes in the occupational cancer incidence among the total population at risk occurring during some 10 to 30 years after their introduction. It is therefore desirable that provisions be made for routinely recording all cancer cases occurring among worker groups exposed to occupational carcinogen A H precancerous and cancerous lesions observed among members of such groups should for thi reason be made notifiable with the State health agency. All persons having knowledge of these cancers should be held responsible for such reporting. The adoption of such measures represents an important step from a public-health viewpoint, because there is a growing urgency to determine the environmental causes responsible for significant changes in the incidence rates of several cancers. .. Sx> 7 * 9 What, Then, Are the Conclusions? 1. The increasing rate at which occupational carcinogens have been discovered during r e c e n t decades suggests that only a fraction of the actually existing industrial carcino gens are known and that heretofore unknown and new occupational carcinogens may b e added to the present industrial environment through the development and use of new chemicals and production methods. 2. There is a great deal of evidence indicating that only a relatively small fraction of the cancers produced through contact with occupational carcinogens has been recognized and/or placed on record. Because of the established widespread industrial contact of large worker groups with known occupational carcinogens, the potential scope of the occujational cancer problem evidently is much larger than apparent from the reported number of occupational cancer cases and hazardous Industrial operations. 3. Medicolegal decisions in compensation procedures of occupational cancer claims should he based on a competent and critical evaluation of the entire evidence related to the exposure conditions of the claimant, the presence or absence and the type of any - symptomatic manifestations observed during the latent and developmental periods of the cancer and characteristic for a particular agent, the length of the latent period, the site of the cancer, any specific histologic and histochemical characteristics, the pro duction of corresponding cancers in experimental animals by the incriminated agent and pertinent epidemiologic data. lv. Schedule coverage laws are inadequate for providing proper protection against occupational cancer hazards because of the dynamic state of modern industry resulting in the constant addition of new chemicals and production methods which may entail here tofore unknown occupational cancer hazards. The statute of limitations contained in the general coverage laws represents its main defect in the fair and equitable application of this type of workmen's compensation law to occupational cancer hazards. 5* Since the prevention of occupational cancer hazards and not financial compensation for established occupational cancers appears to he the more sensible and humane method of control, labor codes should be properly adjusted and enforced so as to eliminate or reas onably contain occupational cancer hazards in modern industries. 6 . For ascertaining the actual scope of the occupational cancer problem and for the institution of adequate control measures, it is essential that occupational cancers and Precancerous conditions are made notifiable with local and State health and labor authoritie 7. A comprehensive study of occupational cancer hazards will provide a sound basis for equally urgent investigation of the apparent extension of industry-related cancer hazards ^arSe parts of the general population. API 06067 Subcommittee on Carcinogenicity API M edical Advisory Committee Epidem iological Studies Kettering Laboratory Buffalo, New York A pril 23, 1955 l' c e n t r a l R e g is t r a t io n No tabulations of the newly reported cases have been prepared for review at this tim e. T his d oes not im ply that p r o g r e ss has not b een made during the past year, but is due rather to the extensive changes in our methods of handling the reports. A s noted at the la st m eeting of this Subcommittee, use of the Key Sort Cards (hand tabulation) was discontinued and IBM equipment (electronic tabulation) substituted. This action was taken in order to obtain greater flexibility and to permit the study of m ore variables with le s s effort. H owever, it did require the preparation of an entirely new code since m ore item s in some detail were included; clerks had to be trained to code and punch; and the necessary b asic equipment had to be assem bled. These activities are still in progress. Although additional clerica l assistan ts w ere assign ed to this p ar ticular project, much m ore tim e w ill be necessary before the change over is com pleted. To date only som e 17% of the m ore tha* 1800 reco rd s now on file have been recoded. It is anticipated, how ever, that the staff engaged in this effort can be further augmented this sum m er. During this period the number of ca ses reported to the Central Registry also has increased significantly. Over 50u new records have been received sin ce January 1, 1954, the date of the la st com p lete report. Two more com panies have begun to send in their records, and the others generally are making every effort to keep up with their current cases. A table is appended giving the number of cases reported each year since the establishm ent of the reg istry . (The participating com panies have been given a code number, but each w ill be notified separately how to identify their reco rd .) Geographical coverage of the industry is now alm ost com plete. Efforts in the future w ill be directed to im prove the accuracy of the reporting and to include a larger number of em ployees in the reporting base. Some participating com panies are represented by a single refin ery. It can be anticipated, how ever, if this p ro g ress is m aintained, that significant figures soon w ill be forthcom ing. API 06075 in /CtwC? 11 * z o r use in refinery operations. However, this bridge presumably oar. only be crossed when we come to in. At the present time the laboratory estimates teat it will tale six generations of mice at a minimum to obtain -ne necessary answers to the above equation. With a minimum life of nine months for eacn generation and assuming that each step proceeds without any notch, this represents a minimum of fifty-four months of additional worn by the laboratory in tne solution of this problem. The report by Dr. Fhair shows encouraging results in attempts at making statistical evaluations of cancer in the various participating companies. It is, however, discouraging to realize that only sixteen of twenty-five companies have participated in this effort and that in the last few years the number of participants may have diminished even more than this. For instance, in 195b only twelve companies participated in the epidemiological studies. It should be quite apparent to the medical members of the Medical Advisory Committee that if there is any hope of accomplishing anything with these epidemiological studies this hope resides in the full cooperation of all of the participating companies. This would then provide a large enough sample so that significant statistical analysis could be made and leads shown which might permit more detailed studies by individual companies or by the group as a whole. Nonetheless it must be recognized that if participation does not continue in this project it is doomed to failure +hrough no fault of Dr. Fhair, but strictly due to the failure of cooperation the part of the participating companies and their medical directors on one Medical Advisory Committee. Since the Subcommittee has been emphasizing the epidemiological aspects on this problem so long and intends to push the epidemiological studies, even at the expense of the experimental studies, it therefore seems apparent that if we are unable to obtain cooperation the epidemiological studies might just as well be terminated. The Subcommittee is in no position to do anything but make suggestions to the individual medical directors who sit in on the Medical Advisory Committee, but it is the suggestion of this Subcommittee that the experimented work in and of itself has no real value since it has no direct tie in with the human experience. The whole meat of all of the work which has been sponsored by tne Subcommittee on Carcinogenicity lies in an attempt to develop an understanding of things that may be of importance to man and if the studies on man, namely the epidemiological studies, are not successful then all of the work of the Subcommittee will have been in vain. The Subcommittee simply wisnes to re-emphasize that for the past five or six years it has seen stressing and encouraging all medical directors to participate in the epidemiological studies. REE/jbn October 51, 195? API 06134 * S ty * ^ e ix r jjo r k 51 ' TUESDAY, AUGUST 21, 1956. L Depart Subject te Beview < Mead Dyes i CTAAELCSpOPAxpMKiportNeeSeltFalasiarCnOelUbsMkLrEo'vOiSEanraRanGdyDttotiymviIFoSreIArpOnSLowAymDIeantwTMosDHtItm,VeaIEmUFPzTinlEnaaraIosrCvRVdttaoiUeoDofrEemcRnt,SBtl My COBTE9I The joint adopted by report unaoimousty the symposium la !1iitsMrWoodsedvyeerse ceaomndemlaoteettropnafrrotmir- subject to review by the Execu!ti t symposium. Its report stated ttve Coauntttae of the Interna that ao ta d dye at present met Uoaal Union Against Cancer, tp "agreed erila ris of safety.' is, thysefore. poU bti that some Twenty-nine dyee were Hated or Us conclusions may bs modi 'unsuitable'' or "potantiaBy dan Mod. gerous" Uh the sutiemaat that Tbs report laid down the baste they should or aa aecoaat "be principle that ao food additives added te ta d er drtak ter a n should bo ussd unless spsetfleeliy or am atati." pom ittad by laglelallen based on Another list confinad twenty- lists of substances that have throe dyee that might prove been proved tnaoeuous efua satisfactory after further teats. strtageat laboratory tesu. The fundamental paper that It went ea to give the first formed the beam of tn r sym- Usta af food preservatives and dyee that were found either ac read by Dr. WHhataa C. Hauper. ceptable, duttoua or -definitely Qennan-bom mwtbet of the dangerous. Duttoua preserv United States dsttgatioa. He is ative* requiring urgent retesting chief of the Envii somanta! Caa- iaciudsd ethyl and butyl esters, cer Ssction ef the National thiodiptionic acid, sulphureous Cancar lastitu ts and is o - h sir- acid and Its dertvativea and for- mea of the ifh p m w . mlo add. Dr. Heuper Hrtad twenty Tbs dai^eroua praserv stives groupe of suspset ta d additives oondmaaad as Tarrhw ginoua aad seventeen groupe of port and to bo avoided for aumaa ta d caetamtasnts. Many of ABSKLDO > w ii wm m i t n w use" included thiourea. tioaeet- thsoe agesta, ha sdULsbave not autid, I hydroxyqufwohns and basa adequately ln m tm iM fo r ROME. Ao f. JO-- A Burnt)er of hydroquinooa. a ll ef tbase Most and are used psrhapo h i the carcinogenic quahtkm. Tbo ta d additives Included dyes, thicken uknI additive used in the United Uhittd tataa aad Europe. ers, synthetic sweeteners aad States and Europe as dyes, thlch* flavoni, preservatives, shorten . enen. sweeteners preeervstlvee ing, bisadme, oils aad fa t substi tutes The food coots minante an# ih* uke ever labeled cancer* Included eaUMsUea ead antro* productnf today by a eympoat gen for fattening animals, pesti um of <h* International UaMM cide rendasi, soot, stan im i Again Cancer. Uttsd by redietica aa potential Other food additives were put ' haaarda and against the steriliser*, aatisprontihg agent* wrapping m atarais, radiation. on suspect Uit as unsafe u n til of agesta estrogens as (atteaiac far poultry sad meat At the ead of th rir laboro the symposium aad Esecutive Com tneir propefties bad been m art Lineals. mittee o f International Untoo thoroughly tested. The cancer experts meeting in It n tt that several d e te rf lA galast Oaaeer were received tat audience by the Pope at htt Rome acknowledged thgt thin onsets' their usa"for daaaiag _ food eoa summer residence of Castel OaaIdoUo. He dsUvarod a brief ad irsa'e d a "serious puttie hsetth iproblem' They unanimously res- U iosrs Usa. theroforv ngr utred esu I drew aad Imparted aa apostaba b iasin g to< "' ' loimtsed :he '`urgent arrsastty of -international eoUaboention for ; Baa ea Three Dyas Dpttstt the' protecuap at mankind" i Hors than rwe years ago. in against surb haaarda as eaaear* itile United States. tha rad erai Food aad Drug Adainistrotlort pioducing food additives. jirehibilad the use of three coal The participants la the sym .tar dyss co the ground that they posium also acknowledged that `were potentially harm ful, Tea |food additives were only sea Idait ago Ut* United Btatsa Court of Appasti upheld tha baa ipart of the vlronm ental vast problem of cancer which a1bn*. laonndOMraendgeNoNoSt1, Orange No 9 eludes occupational and lung ' caTntcie*rss.ymposium was attend! av forty-two cancer experts tram :twenty-one countries. Including seven Americans tad four Rua* suns. It was celled by the con* 'grees of the International Unon Against Cancer held in SSn Pmu.o. B razil, in IBM. API 06196 i"1H- Re C c & 'd r 06204 - 3 - 3) The chairman of the Subcommittee, after receiving Or. Bumper1 Bo m manuscript and the resolutions of tbfl Borne syqposl-- , should write a letter to the Burg-- General, with a cartoon copy to Dr. Beeper, asking for elarlficatloo of the stats-- nts which appeared In TBB Btf TORE ZZMB. Bile should be done on API letterhead and the tenor of the letter should be dependant upon the text of Dr. Beeper's manuscript and the reahlntlona adopted in Bone. The letter will be circulated to the Bribeomaitt-- k) prior to being forwarded to the Burgeon-General. It was the general consensus that Insufficient data la presently available to permit adequateevalua tion of the carcinogenicity of dairy war-- . The Kettering Laboratory was asked whether they would be inter-- ted in conducting the raamarch neceeeary to clarify and establish the status of dairy waxes In regard to their carcinogenicity, The Bettering Laboratory expressed Interest In this research f\f( -ML/'? (yT~ t)MiK C i& 'it/*' for such research with budget eetlastes as to the cost for s subsequent a-- ting of the Subca-- ittee, to be held in Chicago on October 20, 1956. Tentatively, the place of this -- etlog will be at the Drake Hotel, providing the ehalT-- n of the Subcommittee can obtain adequate aeonssodatlons for a meeting roca far the Subca-- cLttee on that date. At this ti-- , the Kettering Laboratory will have spcifi prop-- ale with, acre or le-- , specific budgetary estimates for the re-- arch necessary to clarify this situation. In the -- anti-- , the chairman of the Subecsnlttee will provide to Dr. Keh-- , a copy of the -- Morandus which Is t be distributed under item #2 above. IT . Gehoe was reminded, Just before the meeting adjourned, that there would be a meeting c? the Subcommittee about the time of the IMA meeting In April and at this ti-- , be vculd be expected to present budgetary figures for the year Jhly 1, 1958 to June 30, 195 K- B. SCKAKDT, M. D./ejh Caatrman, Subcommittee on Carcinogenicity Snyteabcr 10, 1956 Attach. - ABSTRACT HB42X0BSEI7S BSTCKBI THB COKPCSITIOI ASP CAA.BVCTeKaXleayaCEHCorPtSoPnW,gMtTOfeHl . Of VARIOUS KKFlflEKr STBSTiKB. wL. * V. Streep !.. k . Yjf-'tot AFI 06213 ' ,,ui<A|u vt i <'J December 1, 1956 To: From: Members of the Medical Advisory Com m ittee, API Dr. John J. Phair The accompanying statement describes the present status of the epidem iological studies conducted for the Medical Advisory Committee. This part of the report could not be prepared in time for distribution prior to the November meeting of the M edical Advisory Committee, but it should be attached to and considered as a section of the document circulated by Dr. Horton summarizing the biological and chem ical studies. .<s'\ f l e l AvO - me Attachment API 06272 APi PROJECT Epidem iological Work D ecem ber 1, 1956 i Following the unexpected action of the Medical Advisory Committee that was ? 'r taken during the spring meeting of 1956, the activities in this field were abruptly discontinued. This decision was arrived at for several reasons. F irst, after the //T-l itui.U'U-h a report to the Subcommittee on Carcinogenicity, the statistical clerks were assigned to other work since they could not proceed with the coding and punching of approxi mately 50% of the reports until either Dr. Horton or Dr. Phair could review ft individual records and categorize the occupational histories. As was indicated to the Subcommittee during the February m eeting, this 1 portion of the records was proving difficult to interpret, and many of the histories required a decision by someone with an adequate knowledge of the various processes employed by the petroleum industry and the job descriptions commonly used by various companies. This problem had not been attacked because of other com m it ments, and it was quite obvious that this particular and com plex task could not be completed by July 1, 1956, the date given for the term ination of the support of the Cancer R egistry. Accordingly, it did not seem w ise to waste effort and money on a project that could not be properly finished within the deadline. Subsequently, a request was made for funds to close out the work properly by tabulating the m aterial presently contained in the files. This suggestion was accepted by the Medical Advisory Com m ittee, and authority to proceed was given in Septem ber 1956. By this date, because of changes in the personnel of the statistical group and other demands on their tim e, this program could not be immediately resumed. However, arrangements were made early in November to pull all records requiring additional review and to have a professional person screen as many as possible. The remainder will be studied further by Dr. Horton and Dr. Phair. It may be n ecessary to tabulate separately the cases with poor histories of employment, but this decision must await the completion of the coding. Preparation of the final tabulations has been set for the spring of 1957, and the com pleted analyses w ill be sent to the m em bers of the M edical Advisory Committee at the earliest possible tim e. The exact date cannot be given now since it will depend in large part on the rapidity with which the coding of the occupational records can be accom plished and the availability of statistical clerks and equipment to com plete the proposed tables. API 06273 41 ESSO Research and ENGINEERING COMPANY p o B ox 121. L , . . (F O R M E R L Y S T A N D A R D O IL D E V E L O P M E N T C O M P A N Y I inden n j MEDICAL RESEARCH DIVISION R O B E * E ECKAROT AH O M O O lffK C T O * N V H E N O m C K B CM C h IA O IN O U tT R IA L M V O IK N IS T HCMACE W StNAKDE pm o m o H |A o T O X IC O L O O IIT I f R T M N D tC N N lS O N M O c h ic p c l in ic a l r c ik a r c n p h y s ic ia n A m t 7 V 5 T API 06275 ESSO RESEARCH AND ENGINEERING COMPANY (FORMERLY STANDARD OIL DEVELOPMENT COMPANY) p. o. Box 121. Lin d e n . N. J. MEDICAL RESEARCH DIVISION O B E M T C E C K A M D T. F H . O.. M .O . DIRECTOR N V H EN D R IC K S. CH E HCAO INDUSTRIAL. MVOtCNIST H O R A C E W O C R A RMDCEA.DPTHO XOIC.OMU.OOO IST C CR THRt iAr NCILO.INCIC. ASLE. NMNCISSIAORNC.MM .PDH Y SIC IA N juyu, m r is. M U i i aristas towiflMcfMlUlNUl SsMMk I M M MslS, m u R i r t S * r l* lfJT IHN f m t xt is 1% is 1 * im * is sill 1m i n i V M a Is I <0 X. V. B W , M. X. as. t. k M is. X. M s lt# If* . rfp/ 1^-7 API 06314 r\ S t a n d a r d O il C o m p a n y D d ical e pa r t m en t VCK B. R EEVE. M. D. 1C O I C A L D IR E C T O R lso n w . b o lv a r d . m . d. iM IV T A N T M E D IC A L D IR EC T O R ORGE M. GOLDEN, M. D. U L D. H A L L E Y IS D C S T R IA L irrO IB IT IB T 910 South Michigan A venue Chicago so. Il l in o is January 21, 1957 itf (9q Mr. D. V. "troop American Petroleum Institute 59 Vest 59th Street New York 29, New York Dear Daves In answer to your inquiry of January 11, I shorid like to request space Saturday, iuril 29, 1957 1:09 to 5:90 P. K. for a meeting of the Sub committee on Industrial Hygiene. If this request should be in conflict with other meetings, aowever, then it will be alright with me if you set U 9 up for a morning meeting on the sane day. Yours truly cc: 1. E. Curtis, M. D. Paul D. Halley API 062I American Petroleum Institute 50 W EST 5 0 T h STREET Y N e w Y o r k 2 0 . N. Y. SION O F M A RK ETIN G A jM O S H O t K V D IR EC TO R lE R A L COMMITTEE 0 C O L l E V .lev B R E iT w fifE R . Vice KING. JR tCCftlTARV AwORtOC* A L .AN CRT O ANDERSON NCER c SA G O * BAKER TER F A IL A R T l ETT ELUMAN 1G H T F B E N T O N C F BRACCKEl ; BURNS in r c u m m i n s rAt. C D E C K E R il DEER ; DEVCRC 2< E S A O O C T O R CORCE OONOVAN 1 ELLIOTT I FifHER FITZGERALD M an FOLEv > FRASER g o lom an March i, 957 O FFICE R S JAKE L HAMON chairman 0* 0 **0 FRANK M PO RTER PRCS'OCNT c h a ir m a n * A B UZZ) vice PRC l e t s ' 0 T C O L LE Y Vice * n i D | s * 0 L C O NN ELLY v iC l *Eft>OCs* H w FERGUSON v e t ***S iO |s- F O PRIOR vie* M i n o t s t Mr. D. T. Staples Tidewater Oil Company 79 New Montgomery Street San Francisco 20, California B B JENNINGS recast Rf * LACEY WALKER sccrc % Dear Mr. Staples: fji With regard to your letter of February 12th, I have no v ; objection to the proposed continuation of a study of carcinogenicity and concur that the sum of $50, 000 be made available to cover the cost of carcinogenic testing of waxes by an independent laboratory. * j` GOULO JR GUZZO HARDIN H AR DW ICK (N H A R R E R |H s H A W L E Y > HILL . .TER L HOLM GREN 1 HULL IERT M JEN N EY rOM JO N ES I' J O R O A N KAMPERMAN IRY J KEN NEOY KENT KETCHAM 5 k n O w l ES ) KOONTZ 1>NK c L O V E LYON Xbelieve that this action should not be linked in the m an ner shown in the draft letter to Dr. Burney, Surgeon-General of the U. S. Public Health Service. From the discussions in the Sub committee on Carcinogenicity, it is apparent that there was m isquo tation and m isinterpretation of the statem ents made by Dr. Hueper. These m isinterpretations did lead to unfortunate publicity. However, I believe it would be a m istake to tie this in any way as a basis for the further cancer research proposal by the Medical and Health Committee of the API. MAJEW SKl 1N F R M A R K L E Y I MEEOCR ES M m il l S 1 MURPHY L'E R N E A l Therefore, it is my recommendation that the letter to Dr. Burney be omitted. Eh l n O lan - A PENTICO RAPP R av Cordially, *u E l R O S E n w a S S E R SAUNDERS *R L SCHW ARTZ *ENECA,, JR '* lNY 0 S K S M IT H S w'E S T A . ' C * '" .R C STEWART D. T. Colley SE S T .C k E l -E w SW EET 0 ' . " h O m p S O N ' * Bv j r ,R . . h UTLEY be: Mr. Frank M. Porter 'ANDER JAGT G VESPER a a ' TS C '*' c w e . l S Na . d c w e s t N- w . r E 1 A *. Es 5M A S Z w S E API 06329 WCfi d . -kW fido . _/ 1.' iV ? rtftid U J INVENTORY OF MAC CIRCULARS. REPORTS, ETC. ON H M D FEBRUARY, 1957 Jo. cf Copies V Aioc "Occupational Cancer - A Challenge to the Physician," by the Office of * Public Health Education, N. Y. State Department of Health. 56 "Appraisal of the Potential Carcinogenic Properties of American Petroleum Products," Report of the Progress in the Epidemiological Studies, The Kettering Laboratory, Dept, of Preventive Medicine & Industrial Health, College of Medicine, University of Cincinnati, Cincinnati, Ohio. 70 "Tabular Summary of Current and Completed Biological Experiments," API Res. Project MC-1, September 1, 1953, The Kettering Laboratory, Dept, of Preventive Medicine & Industrial Health, College of Medicine, University of Cincinnati, Cincinnati, Ohio. 38 "Skin Cancer of the Hand and Forearm," by C. N. D. Cruickshank and A. Goure- vitch. L "Report of Progress in the Appraisal of the Potential Carcinogenic Properties of American Petroleum Products," The Kettering Laboratory, Dept, of Preven tive Medicine & Industrial Health, College of Medicine, University of Cin cinnati, Cincinnati, Ohio. *20 "Thermal Burns," Revised draft by Dr. A. 0. Seeler. 7 "Report of Progress in the Appraisal of the Potential Carcinogenic Properties of American Petroleum Products," - The Kettering Laboratory, Dept, of Pre ventive Medicine & Industrial Health, College of Medicine, University of Cincinnati, Cincinnati, Ohio. il6 "The Cutting Oil Dermatoses - A Review," by Bertrand n . Kriete, A. B., Harvard School of Public Health, March 15, 1950. 100 "Estimated Budget of the Kettering Laboratory for the Investigation of Potential Health Problems of the Petroleum Industry Associated with the Presence of Carcinogenic Compounds in Certain Materials and Products API Research Project MC-1, July 1, 1951* - June 30, 1955*" 25 "American Petroleum Institute Medical Advisory Committee Report for Period I9L5 - 1952." 75 1, & "Tabular Summary of Current & Completed Biological Experiments, September 1953/' The Kettering Laboratory, Dept, of Preventive Medicine Industrial Health, College of Medicine, University of Cincinnati, Cincinnati, Ohio. +5 "BAL," by Raymond V. Randall, M. D . , and Albert 0. Seeler, M. D. 11 "Interim Report API Research Project MC-1, October 1, 1955," by The Kettering Laboratory, Dept, of Preventive Medicine & Industrial Health, College of Medicine, University of Cincinnati, Cincinnati, Ohio. 0 "Cutting Oil Dermatoses," by Harry Shapiro, M- D . , N. Y. State Dept, of Labor Monthly Review, Division of Industrial Hygiene & Safety Standards. 3 "Supervisory Development Services Available from Public and Private Agencies and Institutions," compiled by the API Come. cr. Supervisory Development. API 06342 COPY COPY S o c c n y M o b i l O i l C o m p a n y , Inc. f 150 East U2nd Street, New York IT, N. Y. August 20, 1957 \ Subcommittee on Carcinogenicity Dr. R. E. Eckardt, Chairman Mr. E. W. Adams Dr. C. H. Hine Dr. E. K. Linder Mr. R. C. Mlthoff Dr. M. N. Newquist U. S. PHARMACOPEIA REVISION I have Just noticed the following announcement in a recent issue of CHEMICAL AND ENGINEERING NEWS: USF REVISION The revision program leading to publication of the l6tb revision of the U. S. Pharmacopeia has begun. Selection of drugs to be included is going on and the list is well under way. A call will be issued shortly for volunteers to read USP proof. Meanwhile, constructive suggestions for changes in the present USP general tests chapters are invited. They should be addressed to the USP headquarters at U6 Park Avenue, New York 16, New York. It seems like this would be a good opportunity to investigate the possibility of revising USP requirements for paraffin. A 6 you know, present requirements are archaic and do not list tests presently used by the industry for maintaining ouality. In our opinion, the specifications could be considerably improved by changing the melting point range, requiring as ASTM color test, and oil content. Also, eliminating the USP acid color test. USP^ *2-1 r u tila G S & Lf A C P '.lgp cc: E. 0. Mattocks Sincerely yours, /s/ A. C. Fabst A. C. Pabst Industrial Hygienist Medical Department API 06387 * Esso R E C e se a r c h a n d n g in e e r in g (FORMERLY STASDARO OIL DE *'ELOPMEST COMPANY) ompany P.O.Box 45.Linden.N.J. 1EDCAL RESEARCH DIVISION O B t * * E C K A H O T PM O M D DIHICTO IE B T P A N D E S E N N 'S O N M D Assis-'AN-' 3m*cTon >. --E N D R 'C K S CM E ->EAO N O U l T^ I A - Y O I I N H T 'O B A C E w G E B A B O E P m D M D h I a O t O X lCO LO O ISt Ociobar 1, 1957 te. I. A, la*ra Oallage af te iltira - U t e n eiiMd-- n if, a m Dm r D p. I t e i mX mU tetinniiy jaiat e trtarat eM plat eja aarf iterasteartaetea frltataartrMaratalisitlearaA tteeet-eaa. , X raraafaprl4aaraltlrenraasfimtgerraaaaiaralfait/teee.rratlaeliaraiiarSaaraaateaiaateiftlt.eeffttxaerasisrp. aiftIeritaei iit<Metp*teajaarriaaraSttett,eteea, aliaailaaltrae,ratleai TitaeraMrAaOraaaaiaaraiM--aliatae ilifateliraaalaargaai,tela ag--ralar it tlara it,eltietelanaaraali tteeari*atlete.rateterira . trealnllaa--a kl aatletea--f --tearaarapratetiearlaate--tenaatteerateaI f11a0t.e taiplraapearaaal*l--a aftirterai lplyaarate tgeaUjaaaartaeteiteteaIHl i,f allasapaarraarBiaallaataarai.te *fla9r--id aalayarllateteftaagr ftaelraatei tlae stieftrraafrateiiataar haa H te te aa a lte tela t e i aai raU ran m i X aali aatlalrate ite i fafrateratelp ra te i ate tesa itaa la tetra-- te itaaaaa tela a lte par pr&ar iltiteer tlae*taearlada*pgrtreaafeiraattateglarai taeraiit1lea Ialrit.e aXp--araalfiilaitefaratelri-- agnrrraaagailpaaaapri^prtaeaglaatette l i i f paa aali la i ra ter para eraraate nauralag ite r. ftap indp jraaia, 1. I. nuumv, K. s. mte/ea. j-h M raira a f ite tei ApI 06388 .tiae ea Careiwegaaieite te li a i th IlaakarteM Sepiaaber 27. 1957 (Oeteter 1. 1957). (3) (t aiM - v /fr /d . b tp h l `~rt'S7 per gram of wax. It was the considered opinion of Dr. Shubik that he believed this quantity of the known carcinogen, 1,2,5,6-dibenzanthracene, in milk carton o wax is undesirable and that the petroleum industry should establish an immediate standard which does not permit this much carcinogen in the finished product. Lone ranee work then would a tte m p t to establish a standard based upon biological testine* In discussions which the Chairman had with Dr. Hueper at the recent Lung Cancer Workshop at the American Cancer Society, Dr. Hueper indicated that he was willing to sit still as long as the industry was willing to approach this problem with a reasonable, rational attitude, and as long as he was kept informed of the results of any work which was done. The Chairman indicated to the Subcommittee that the Three-Man Wax Comnittee appointed by the Medical and Health Committee of the Board, had met in Chicago on October 21* and unanimously recommended to the Medical and Health Committee, that work be done on waxes to the extent of approximately $100,000 a year for the next three to five years in Dr. aubik*s laboratory. Copies of the report of the Three-Man Wax Committee will be made available to the members of the MAC through Mr. E. 0. Mattocks* office of the API. The meeting was adjourned at approximately 10t30 a.m. )C i f iwx,u l u c t U R. E. ECKAROT, M. D./cjh Chairman, Subcommittee on Carcinogenicity November 1U, 1957 API 06396