Document jgEJgO656yyoBG4Od4EEk74oy

-i -y. * V "V* tit'iffiZf *, > -'1 'S< '"?*- - |, >'.; -'y i i'-lV-yj^V'-.'Cil P. T. i'iofo, A. Ilipoiti, tnul A. Copula = :., , yy- V-; Kmlfntotton was. Iffcjvil.if - and ,fcn pytskcralosis -Was , farlilapinous;:7tiiiCrSvpossl1|C^cf,tc;,yiyc ^(catuij^^icliVj obscivaj in the ,-uv'OS of the tumor It* which the cells, were fihtosis and Jty'n.linosis, TMG pefichoiuttilrn appealed obeli a; 'loosely i'r.*'-'cT.alc<* pll`1 (titilerrojur, an individual rather than a computed flrul t!ipc|p(a||y (ihtnua limit!, collective "type of l.eratim/atinn (lup,. 'll. !** tlyskcratollc ideas, In s'.unq Cases, the liimot p,mw(h was iciatcvl to (ho nape, ' a few epithelial celts (ended to form pearls. The tumor seldom tire cndoeirotulial ossification occur iiiir. below the *'epiphV,! (fri? "Wra-Mpf showed ait undifferentiated prowtlt with ccllul.tr plcomotphism and several mitotic fipuics (l ie,. 5). A few tiimots show ed little nests of isolated pale cells (lips. 6 and?) of 3 (>'pes; mucin-produchip, colls (orip.inatinp front the duel tpithtlium of sweat platuls or sativ.v.y plartds); squamous cells; plate." Ossification was, rrrcpulaf, so ih.n osseous liah.ccu' varied f,realty in llriclmcss and contours. In oilier cases, foci, active cellular proliferation, cartilaeinons areas, chofidri dcvelopinehtal nests, hintl calcified lteurcs occritrcd Ih t"' deeper,portions of the trabeculae (Pip. IK). and intermediate tells with minor tendencies towards The new formation appeared to Ire tor uslrocltohditrma ,v diffeicniiation. consisted essentially of d bony protuberance capped Respiratory Tract. These tumors, alihouph occirtrinr; rarely, cartilapc and a fibrous layer, which represented i wcic mainly odchocaruinomatous. Only in 1 rat did we observe perichondrium. 1 an cpldcimoid tumor orir.inotinp, from the epithelium-covering The fibrous iayer was Continuous with the periosteum, .cells. Sometimes, (lie tumors v.ctc seen iii their early the adjacent cortical bonc amt extended inward to fompscj ; development nnd consisted predominantly of chliic or separatin'1,arid cnePasinp, lobules of caitilupc, . y-f r ' columnar cells arrauped as rcptdar or irrep.ulnr tuhtil.ii and Control Animals. The control rats wcic kept under tlie f.v papillary elements (I t". 8) aitrl supported hy poorly developed conditions as (lie cxperiincnlal rats and at the appropriate 1?; Tlhfbus sboma (Tip, 9). were subjected in a constant flow' of air witiioul vi' In other cases, p.lahdular stmctuics were often imperfectly chloride. N'ortc of these animals developed tumor; or tire if formed n,!id appealed as shert-lihe prolifctalions of of paruicitymal lesions developed by the tats that Inh. undifferentiated or pleomorphic diameter. T he cells showed a vinyl chloride. In a very few of the control tats, theic we. tendency `to extend into the pulmonary parenchyma, thus swelling of the liver ami kidneys. flmulatinp, illd tnicioscopic features of the so-called alveolar cell ratcinciiitii (l;lr,, 10). .Sometimes, this was (lie provailinp, ' pattern. The ptilmoit.iry-.ilr sacs were limited by I of. more Discussible, .layers Of cubic, columnar, ci polyhedral cells with abundant ,, cytoplasm lit.it was faintly eosinophilic (l ie,. I t), ,lic(|uciitly, As In many carcitic'i'.enesis studies in which multiple tun. ndcnopaplllaty t.xctcscciiccs sptcadinp. into the alveolar spaces arise in different tissues and otpans, the data must he evalm,- . wcic present. .` hi terms oT a.mote prompt positive tmpuuv: to he ohtai I -In Some areas, foci of cellular polymorphism with with (lie ideal concnifration of the carcfitni'ctiic cofnpott 'hypcrelnomatic nuclei were noticed; mucin svjs produced in The cutaneous.system Is the most susceptible to the oncor.ei varylne, amounts and secreted Into tit; lumen of, the tubules effects of vinyl chlolide.- and acini, There weic small pools of mucin in which sipncl tim; Our cxpeiinlentyi data do not explain wtiy the cutanv cells occurred, either alone or id small clusters (Pip. 12). The luntors developed hi the same site, i.c., the topion inehid , olvcolar walls were often rjuiic thick and, at times, showed dd the atoa. In which the siihmaxitljry and parotid plain!; Inflammatory infiltration, ' located. It is possible tiiat the Salivdty elands mey by tnss'l As mentioned hefote, if slnple tumor showed squamous" In (lie concert tra I ion .of Cxcrclion of vinyl chloride or sOulo ' structures antP appeared 10'have heed formed- mainly by its active decomposition pioduets. Th!s itypolhtsis Is shot' y. spindle and otal Irlrdiffcreitlialcd cells (i i!t. i2). supported hy, niotphulop.iea! find tups sitowinp, the, spec;, ' ` lloilcs. In tlic tnct.icaipai and metatarsal regions of tlie A ItlidcItcV of' tile'developed 'junior to appear as' t'i;V^fJ^ff:jif*if litnhs, a larp.e proliferation of eaiulapinous tissues arose mucoeptdcniiotd carcihOma, wliiett iudtcaics the . act odtwan! fiom the pnlusuuim and, frvttd the appearance of Its conitil.tition of the munis platululat cells to the limu't *" ' ccllst t'l'sdtirtl to dcr'vs diiecdy fioin the cortical 1-oiia (Tie. * rrowth ffncli l.lnds of iiislotypcf :ue oiton tcl.i<"d to t1'" . H). The perf&Uhnti also prcw and in some areas spread as pkmdtilar opprepatei, :mkI. therefore, Ihe-hispopenesls olTitir; fmpctdlkc piolonputlons fomied caitilaec (l ie. liuicospidcfii'oid c.lteiitnnia iris been ttsitv-lerl lc> the c.T: ^15). In those places, a. ptadtu! I'ansition hetv.rcn fibrous inletcalatqvLduets. 'Hus iiypoihcticr! inletpteC.p.u^i1;'.;'!. scttrlap.e, |',|*M,ostf,1!l', and h'l'v1 red l he iimb-vd, Confirmed hy future cxpeiiments In hlmli the .ict.a;: of I lie newly lormed. cartilapc appeared iiter.nlai With atypical vinyl rhloiide should ho u,Jtrtcicd to tli.1 s.thvaty system. areas; tiro cells, wide!) bad mu lei hiper than the normal the ronrentratirms us-td, satmation -1 o.('tiinp of the oiio' dr'cyrs, lay >-i vwddnrmc'1, rapoilatt'd laemrae. The cells tiuf'ht well ho cvjme'.i'd. tinder ' occuned smp.ly, id pans, or In ten,ids and, alihouplr of iialiir.il cleausim; IijIuI of the ral mrehl .tt.ti ,1 M.;m; . diffetenl si/c and shape, (hey tisuallv contained ;t sinple, hutvsilott protden* with Suhserittont COl'ce I il ,1 t It Mi f ` \ ` ' dnikly slaim'd nnclctis. 'J he cartrlacrnous pnnvllt was not clilothle In ltie sahvaiy ' pi.imh: 'Mo. 1 Me d ' xim Itoiunpeneorls, as shov.n by ihc c'.unsmn of the Imper-bhe nmcenii.itlfui rruild ' the te.wll ol t ddtieiitiy o pinlonpaliorts in1 u |tre hound.uv o; newly titimed tissue. complete cleam,im; hv the tat. Ilesitles the choudiot'ta tic, choiuhoc) tie, and anp.ioniatous I tie neop'islk' "'spoils'1 of live hover u`'pir iton; ir ntcas which indicated a rapid pauwiii, there were also alihoup.h uT lesser imu'.niiudc, is of relevant ('test, t meP Si . , S* > .^n* ' 1 - CUSAROSS 02238 ""V 1 *..,, |i:utoii '}'?'< H.tofjWiolc{-ii;illy sititil.n It* fit" ` " ` ^;' t)(ocl.V">v 11^ fVj>Oiii7c<Iirirc' .\.;I;c"Tuni'ikrii.midiH.'riiefi^': t JUi:`iiCl'VP(iU'cli' tll;,i nn.ciU p<i(^rci:ii,tcils tnay m.]ll1c of tctatninf vinyl chloride ot itss licccihipiisiticill sccinvclo. be iclcvanl once mote. Obviously, n '- 'j-dcij'icintioli Is k'cjnhcd for the palilniivgmeniwe'esiUs oufllliCL' ! ;';,,,>$ ami for tlwir simuliancou* hicklnicc :i ll.c bvcl ' If 11 1 ' * all 4 liin!>t* -m - , ^v, ,' . '* rj"-\ 6. Ilinpei, W. C. Cawcr imiiicli-iii by I'nli titeifi.ut'amt f'*>ij'iiictitc'?i:'?:' '' I'l..nllts, i. Kalb,Cancer Inti.. ,/,/ loil.'i- I02).l9til. .-V- ' '/!''V.j?-''J. ^?. Joohlu;*t*'.,i'm,. K,.. IliioMt, I... Ilr.iiul, iI'.;Y--aanndd' I'tand, 0C. I'olymnicrt V'--'1: > ;;(Iom,.I |>eter,ma.U;: ^ t.lu>* *,'lr(|siic" ' tltJllni*. . I.arly I rclicnplaSla! ' Relationships lo ''' 'f 1 Hatf * \ pc. Mouse Strain,Taiid Sfc;t.` i. [Mini." Cnhccf Iml.i 4-iy 4s%'^;iUi 'ft;-1 ; \f* xrtucNCES ' " 1- ,-f<*'iS-y`'CJi'-^1ir.y3>i,V-T<78J<?79J. 197O.'^rK; H.fp* -* j ar <)**H 8. Kf,".;il, A. iApfcicrriiminecnl.iil illtbaosnlnnniinnrfecnncciiist CaitiUc--.:udl try SSyyinllteiic I'olytiicrj (I'ljUics), MrdiiMn.r, Mnu oiv, /: 2 15-237, 1965. ' | (itn'ijcfi M.t nnrl Jl.ilcj, It. Prevalence t>f Ilclrmplnidy in Mastic I fro-induced I'riitiary Saicomas., Util. J. Cancer, 20: 553- 563, j Hr.-rul, ft., /.nd Runet), L. Polymer 1 umotipcitcsis: Multiple ' ' I'lcnfoplaJlic Clouet In I'rigrily Older wiili Clonal Inhibition. 1'ioc. , See, i:\fil. lDol.-Mcd., J2S: 11 53-11 V 'J6S. 1 (ji.irrd, G., lluocta, I.;, ami lhand. I. Mahp.mml Ttansfotrnatlon and in. Non-clivltlmj; Cclli duiinp 1`olyn.n fUtnahpenc.'.is. rtocSov.i hn. Mcii.. h-t: (>n~ont ihi. | j:rj.tJ, 0.. Ims/rn, I.., and iiUml, I. Caicine-fcnesis from Polymer Jnifl.mls! New Aspects Itom Climinosoni.il and Transplantation jl^dici duilnp I'renialljjnancy; J, K'oti. Cancer Inst., dP. 06?-f>T0, im .: 4 ; 9. Maslfotn.itlco, I!.. I ivlu'r, A. M.. Clui.ll, ll.,;.ilid l),mrl|Tt, D. Acute , Inliai.ition To.vioiy of Vinyl Chloride to LnhO.Mtoly i AniuuU. Ant. tndpll> p, Asun:. J., J/.- 39*t--3y7, 1'ldn. .; 10. Toil.ciM.in, T. It.. 0> cn. I ami Rout,A'. K. Ilte/Ioxicily of Vinyl ,/' Clilonde lit bclciniined ly- Rri'c.ilr'il isxpr>sli/u of l.nboraioty 1 I' I AtilmaU. ImJ. Ilyp. J.. 35 I-3GI. Oeinbeid90i. ,'1 ; '}: a 11. Van I'uicn, It. I.,,' Siv.it:, A,, CoiiUcliir.idi, .11. M., Nat/, C.. anJ'Xv* Mdcltionnc, ,S. Cejc^ino^.-.'iclty of lljlo l.lliett. j. N'atl. Cancct lmt.,yj. 48l-d8C. 1969. i 2. ViolJ, I', l,, r.ithohyry of Vinyl Chlnlldr. il'iili lilifm.ilionai ' , , Conr.iftx f Occupation.il llealt'i. (Cciinmiinii.alion Ko. 38), ' Tokyo, 1909. ', -. - i' ' , ..t'i; *'. ' * ' C," ` v+'v'ir'*- Photomicrographs o the original orticio aro nob lacing disbribiibod.. tv/ibli bliis copy because of the poor quality of their reproduction. * ' ,*Aps '' ' - I s. ' i-.4, `r'*\ '.y ` ' k . - v.; l ift. I to IS. All V.'ctlonr wit tl.tineil uitii II 1C ~ I lf. I, SqUanir'tU tell papilionta or the thin, X 2S. - - .- i 1^, I if. ?.Tfa;isilional tl.ifc (roin p.ipilloui.i m iiirill/ntivc. type of cancer, X 80, . . -^, . f'N i l.inwjJd:<!Skiccul,i 3 ht.mcli to form secondary processes sluwltip, lioiny pearl ftHinrtTWT'fm/iut's). x ?S. ` ' "!'v I Ip. A, Itysl.ei.ilolic an a. I cw cpitludi.il cells v.ith a lendemy to fmni sshoils. I.iule cupaeuy lo develop info homy pcnils. JJO. II i A<)pifjl cells p.uilv lacking, p.h ldes and shos.inn consl'letahle variation in si/e, slmtic and inarty'lttitotic lipnter. y, 2Sfl. I if. C. M.icocpidciniedd .iporii'.irt*. X 100. t nuo'. C'-euriciKi of Ii>dlopic cpideruir.id c,lli, hi:;.! sell -, ccluimi.'.; el1,, .u.3 . :,/|.|idu cell; in .a.iout .. 1' I if. T, Mucocpiilentn'id skin tumor, showing differentiation of ma<scs of snuaniods cpiiheiiilm fiom coluninrit cell:, Iminc end ptolilciatini! Into 'i*rJ'd tuhul.ii spaces. X 100. I if. Ii, MirUMinthilat1 adenooteliiorla of the luuf'. aiismr from a sepmcnlal htonchus. X 25. -. I if. 9. I'etail of | ip,, I; rimU ;op (iihui.it apprep.ites nude up hy Cells js illi liyperehtoiilatic nuclei. I G 10 Kndtil.tr (<i mu hiol.i i .dt e olui utiii'us-M i re Imp. edcMoc.iir iuoina. X 100. * if. 11. hciail of l ip. Ill, 'lion ian nIsc>'!'" i me p,tin in. X 250. l If. IT Macilspiciducmp cell' ss till In pert. In cun.i tic and pieoiuorpluc nuc lei and occui icncc of sip, lie I i in p sell:. X 250. I!d|ii.mmus i ell (.iicmmna of Ihe lunn, X |(Mi. n;_ I -I. Oslvcu hoiidlOfiia ties elopmp as .1 pm I u he rant c from I lie si nail hones of met u a: pus and me la tarsus. X 25, i if. 15. MJfnifn ,itum of I'ip. TC f he piomhcrjMCc consists of hone trahec uhc, capped by tarldape,am) a fibrohs layerfunctioning ai u.dinniJiuitii, X I Of)*, .j, I f lC. Oj'tiu.hnmlmm.1. Caitilapm.'us ( inivlli r'ui.u len/ed by [im.er like ptnb.fi lalimt, X I 00. * '! ) T () S i( .) mill 111 mu. An i m i r, ,lm I n .mi, i 11 < mi I u i l mu. >` 1(C). ' ``t- 18. Cc Uuljt a lea of ,m s'sts os lu'iiilmm.i slu'u in i; ihe li.uiMium I turn sai til.ij.o to osteoid. X 100. CUSAROSS 02239