Document jg0MbL20qM1N8Zgj89dzG9E32

-- 3~F^ Interoffice Communication to Flynt Kennedy From Tom Grumbles oa November 17, 1980 subject Vinyl Chloride Research Committee Meeting Several issues were decided and several questions were raised during the subject meeting. 1. Work histories of the study cohort will be updated for the period 12/31/72 through 12/31/79, as recommended. The proposal will be amended to reflect this change. 2. The last paragraph of Task 7 in the E H A proposal, dealing with verification of the original cohort members inclusion in the study and cohort additions, will t>e deleted. There was lengthy discussion of this issue but thtTbasic decision was that we are attempting to update the "present" study data base in terms of mortality ex perience and no alteration of the cohort is prudent or necessary. 3. E H A had proposed dropping the exposure determinations used in the original study (pg. 3) for the follow-up study. This information is al ready in the data base file and it was the agreement of the committee that it should be used. However this classification scheme will not be used in the updating of work histories. This was also discussed at length with the basic agreement that after 1974 all exposures would be in the low category. An effort will be made to put cohort members into the following three catagories: (1) VCM production only (2) PVC(resin) production only, and (3) both. The benefit of updating the first study versus doing a case control study on the known results of the first study, i.e. brain cancers, was discussed. This question was left open for future consideration. Although no actual financial committments were made at the meeting , CMA will soon need to know who will support the follow-up. CMA is currently assuming all those in attendance, or those supporting the original study, will do so. The support asked for will be based on 1979 VCM production and PVC capacity. A formal request will soon be mailed to ascertain company financial support and company records support for the mortality update. For the sake of brevity little detail of the discussions is contained above. If you would like to discuss these issues, please feel free to call. t - Thomas G. Grumbles CCS 000002550