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BASKS&L JL.^BOEATOR Common Name; inorganic Lead Chemical. Haras; ---- CAS Registry No.. s Chemica3, Structure ; ------ -- i Physical and Chemical Properties; Form: Molecular Weight: Boiling Points Melting Point: Density 5 g Vapor Pressure; ` Conversion Factors; Solids ------- ' ---- Recommended AEL 50 ug/100 grams of blood Blood lead concentrations represent the most effective way to monitor an individual for exposure to inorganic lead* The diag nosis of excessive lead exposure should be based on history of. exposure, clinical symptoms and signs, evidence of increased lead absorption, and significant biochemical changes. Individuals may . present increased blood leads without clinical effects, in the range Of normal background (20-40 ug/100 grams) biochemical changes such as decreased delta.aminolevulinic acid dehydrase (ALAD) can be measured, but this change is apparently without physiologic consequence. At blood levels from 40-60 ug/100 grams, other biochemical markers indicative of lead exposure, aminolevulinic acid in urine (ALA), and increased free erythro cyte protoporphyrin (PEP)`are elevated, again without serious consequence. Blood levels exceeding 60 to 8Q-ug/lQ0 grams indi cate overexposure to lead* although frank signs of lead intoxica tion including anemia, kidney function changes, and other clinical signs are not apparent until the level reaches around 100 ug/100 grams. While no impairment of health is evident with blood 'lead levels as high as 60 ug/100 grams blood, lower blood lead levels are desirable and will provide an additional margin of safety. When the bloOd lead concentration exceeds the recommended limit of 50 ug/100 grams blood, action needs to be 1- DW 3 02^^^ " * M -*-^*^DUP04001'l214 taken fcp determine the source of exposure and to initiate appropriate preventative actions. Medical Division has prepared instructions for blood lead determinations. In these instructions an airborne lead concentration of 30 ug/m3 (8-hour TWA) is considered an action level for initiation of blood lead determinations. Also to be considered is the 30 ug/100 grams blood lead ceiling concentration for women of childbearing potential (memo, B, W. Karrh, C, F. Reinhardt 3/23/81), Richard C. Graham smjh August 25, 1983 1.18 INM.JH3 \ T T~T DW 3.031416 DUP040011215 1"