Document jNyGRa3GbKkbe94L53b7g23O5

July 16, 1969 Joseph C. Street Professor, Dept, of Animal Science College of Agriculture Utah State University Logan, Utah 84321 ' Dear Professor Street: Dr. Cummings Paton has asked me to reply to your letter to him of July 3* We are extremely appreciative of your thoughtfulness in informing us of the paper which you have submitted for the next meeting of the American Chemical Society. As you can imagine, we are very interested in learning of new research efforts that are underway concerning the polychlorinated biphenyls. I am sorry that we can not provide at this time pure isomers of the various chlorinated biphenyls. We are investigating the possibility of separation techniques since a number of laboratories end agen cies have asked us for pure isomers. In our own rather extensive sampling and analytical program, we are U3ing the technical materials for reference. Perhaps you would be interested in learning that we have a number of toxicity and research projects under way. These include two year chronic feeding studies in rats and dogs; three generation rat reproduction studies; studies with chickens to determine possible toxicity effects on the birds, egg production, hatchability of eggs, viability of chicks, egg shell thick ness and calcium and phosphorus content. The above studies include three dietary levels and controls. In the case of the rat work sufficient numbers have been included to allow sacrifice of a significant number at three months, six months and twelve months. DSW 433769 STLCOPCB4086877 Joseph C. July 16, 1969 Page Two - We have discussed with our toxicological consultants the question or undertaking studies relating to the induction of hepatic microsomal enzymes. For the time being we have decided that more toxicity data based on the usual parameters for establishing a "no effect" level would be helpful. We learned recently of one study abroad where chickens fed a diet containing 100 ppm of 60J5 chlorinated biphenyl for a year showed no gross effects. Unfortunately, the study was not as comprehensive as we have undertaken and would not include the parameters mentioned above In connection with our studies with chickens. X expect that some time this summer Dr. Robert E. Keller, Manager of Applied Sciences for our Organic Chemistry Division, and I will attempt to set up an itinerary to allow visits to those scientists who have contacted us about the FCB situation. We obvi ously would hope to include a visit with you and will write you further as our plans develop. Very truly yours. Elmer P* Wheeler Onager, Environmental Health EPWiJu c.c. Dr. Cummings Paton b.c. R. E. Keller W. R. Richard DSW 433770 STLCOPCB4086878