Document jNmL9zQL8OrJRRqrMkXv4DZXk

ORTHO-NITROBIPHENYL (Toxicity Data) Monsanto Technical Bulletin No. 0-D-700 August 10, 1951 Development Dept., Organic Chemicals Division Monsanto Chemical Co., St. Louis 4, Mo. GENERAL STATEMENT The following data pertaining to the toxicity of OrthoNltroblphenyl are based on reports which have appeared in "The Journal of Industrial Hygiene and Toxicology".(1) Tests on rats and rabbits, as experimental animals, show that Ortho-Nitroblphenyl is toxic to the following extent: A single, lethal, oral dose (LDeq)* admini stered as a 25# solution in olive oil is 1.23 grams per kilogram for rats and I.58 grams per kilogram for rabbits. Indicative of the fact that the method of preparing the compound for administration has a marked influence on the rate and extent of its ab sorption, the LD-d in the case of a 30# suspension of Ortno-Nltrobiphenyl in 1.5# aqueous methyl cellulose, administered orally, is 4.11 grams per kilogram for rabbits. EFFECT ON THE SKIN Repeated application of Ortho-Nitroblphenyl (as a 25# solution in olive oil) to the abdominal skin of rabbits Induces no signs of local irritation nor does it appear to cause systemic illness. Patch tests on a group of 200 individuals, in which the Ortho-Nitroblphenyl was applied as a 5# solution in Acetone, resulted In no positive reactions. The con clusion drawn is that according to the test and applying the material as a 5# solution in Acetone, Ortho-Nitrobiphenyl is neither a primary irritant nor does it appear to be a sensitizing agent. (l)The Journal of Industrial Hygiene and Toxicology, Vol. 29, No. 1, pp. 1-13, Jan., 1947. U**i b*T>nd OUf cora,l- The Honuito Chemical itlicl with 06142 80 TOWOLDMONOQ38452 INHALATION Inhalation experiments indicate that vaporized OrthoNltrobiphenyl is not safe in a concentration of 0.3 to 0.5 milligrams per liter of air. The maximum safe concentration has not been determined. EFFECT OP LETHAL DOSES The administration of single, lethal, oral doses of OrthoNltrobiphenyl to rats and rabbits caused unsteadiness, an increased rate of respiration, marked muscular weakness, dyspnea, and death in coma in from one to eighteen days. SUGGESTED INTERPRETATION ONB possesses some degree of toxicity, but this makes it by no means unique when plasticizers and solvents are considered in general. The toxicity is of the same order as that of trlcresyl phosphate and trlphenyl phosphate. The ingestion of Ortho-Nltroblphenyl or the inhalation of vapor, mist or dust must be avoided through proper engineering and safety measures incident to good housekeeping. Finished formu lations which may be doubtful as to their ultimate application should be tested, and contact with food or other possible avenues of ingestion should be avoided unless properly designed tests prove that such an application is safe. Bach new use requires careful consideration not only of the new product but its use and conditions of use. The inherent properties of Ortho-Nltrobiphenyl indicate that it is worthy of serious consideration in plasticizer applications. In the event that this statement does not cover a particular case, we shall be glad to expand upon it in detail upon request and within the limitation of the available data. The data set out herein is from reports received by us. We believe in the competency of the investigators but interpretation and a proper use of toxicological data to suit not only the product but a given set of conditions are essential and must be made by the user. law:wa-750-851 Printed in U.S.A. TOWOLDMON0038453