Document jNm58e2RvK8Xw9LkVL8KqvNMp

CHEMICAL MANUFACTURERS ASSOCIATION REC ~' December 4, 1981 Dtl019ei TO: Vinyl Chloride Program Panel SUBJECT: Up-date of Epidemiology Study DEP/-.I -- iT The Vinyl Chloride Program Panel for December 16, 1981 has been cancelled bility of several key supporters of the A new meeting date is tentatively set f meeting scheduled he+**-* ' `' `""udy. 9182. In the interim I^would appreciate a reaction (by phone or memorandum) to the present situation. There is also a new proposal to be considered that would split the present study into two parts corresponding to Phase I and Phase II of the present EHA study proposal. A separate contract agreement would be drawn up for each phase. The work product at the end of the first study would include: 1) updated study tapes, and 2) hard-copy summary of data on the tapes and an indication of the completeness of records. EHA would then develop a proto col for the second study and submit a bid for completion. At this point we would have the option of taking the study proto col to another contractor or continuing with EHA. I look forward to hearing from you on this matter. Sincerely swsnan CRS/seh Formerly Manufacturing Chemists Association--Serving the Chemical Industry Since 1872. 2501 M Street. NW Washington, DC 20037 Telephone 202/887-1100 e Telex 89617 (CMA WSH) Liver Angiosarcoma Caie Circulation Dr K S Ullllanson G Paddle D P Duffleld W G P Adana - (5 copies * ICIA, AECI* Duperlal) John York* Everberg D W Pleater H R Jervis* Hlllbank Brian Hasler* Vinatex Peter Heron* BP R H Hards, BIP Vinyls J T Carter, BP T L Phillips* BP P Lewis* CIA J P Taaalgnon* Solvay J Jauvert* Chloe Chlmle* Paris Renzo Hattiuasi* Montedison P Lechaude* Solvay B List* Lonza P G Claus, APHE J G Kammuller* Shell S Wejdllng, Kemanord C Rangnes, Norsk Hydro Terwleach, CWH H Ennlnger* VKE P de Voogd, Shell E Lloyd-Jones, BP Owen Jones* Hlllhouae Brian Bennett* Hlllhouae Peter Wright, P & P Wilton F W Beat, Everberg C Celia, Montepolinerl G Dupont, ABIE C Bishop, EMAS B Werner, EMAS R Splrtas - NCI/NIH BBTHESDA R Kaminski - NIOSH, Clnclnattl Dr R Owen - TUC Dr J Stafford (8) SEE I Vj Dr T R Torkelaon* Dow Mr J Lawrence* SPI flSTt $JLla*u die Mr J T Seawell* CMA Washington Mr R N Wheeler* UCC idDH Dr A Ross Adams, Air Products Dr Mayo Smith, Air Products Dr John Barr, Air Products Dr Walter D Harris* Unlroyal Inc Dr Robert K Hinderer, BF Goodrich (Cleveland) Dr R A Krueger* BF Goodrich Dr M N Johnson* BF Goodrich Dr J Possberg, Wacker Dr J Rety, Chloe Chlmle* St Fons Dr Aubrun * PCUK Dr I A Frledel* Berufsgenossenschaft der chenlschen Industrie* Heidelberg Dr E Ernst, Berufsgenossenschaft der chenlschen Industrie* Nurnberg Prof Dr Ihiess* BASF Dr D M Ferguson* ICI Americas Mr A G Mash* ICI Americas Dr Gary Ter Haar* Ethyl Corporation Prof. C Maltonl* Bologna Dr J William Lloyd, Osha Dr David Bryson* AG Division Mr S Nakamura* Japanese PVC Association Dr Peter Baxter* CDC Atlanta Dr A Munn* Monsanto, Brussels Dr R E Gosztonyj Jr, Tenneco Chemicals, Saddle Brook (NJ) Dr Donald W Hillman* Diamond Shamrock Dr G Kent Hatfield* Diamond Shamrock Dr Pierre Bertazel* Milan University Dr Hans Popper, Mount Sinai Medical Centre JS/MM/D-58 17 August 1981 PJXS79170920/WPX Wide 11 9^951 ian wt-q PREFACE ACKNOWLEDGEMENTS, SIGNIFICANT CHANGES AND COMMENTS Thank you for your letters and continued Interest in this compendium of ASL cases. Notification of new cases Is trickling In and regrettably we have knowledge now of 91. Confirmation of cases In some instances seems to be taking a long time but one Is still left speculating whether the ASL case rate peaked In 1975-8. I am grateful to Dr P A Bertazzl of Milan University for his letter of 1 June 1981 giving details of the Italian ASL Case 04 (the third to occur in the VCM/PVC industry in Italy and first 1981 death to be notified). Case 04 started work at SC Ravenna In the first year of that plant's operation if my records are correct. In his letter of 24 February 1981, Dr M N Johnson of BF Goodrich gave me further details of US Case 17. This ASL case was diagnosed In 1974. The deceased man's family were unwilling to permit a post mortem when he died In 1980. Mr I A Friedel of BG Chemie, Heidelberg in his letter of 8 April 1981 to Dr F W Best of ICI Europa has informed us of German Cases 18 and 19 who died In 1979 and 1980. We are grateful to Mr Friedel for this information and for his detailed corrections to earlier data. The paper by Dannaher, Tamburro & Tam in American Journal of Medicine Volume 70 Feb 1981 pages 279-287 seems to describe US Case 17 and also confirms it as a BFG Louisville case. Could Dr M N Johnson please corroborate this? 1 have embodied the data on US30 given to me by Dr Gosztonyl of Tenneco first as the 6 February edition was being mailed. I enclosed an addendum dated 24 February which I hope you all received. In a further letter dated 10 March, Dr Gosztonyl said it was conceivable that in his years as a maintenance mechanic (1964-1970) Case 30 might possibly have had some high VCM exposures. I have added Table 13 to remind us that there are at least 6 plants in South & Central America as old or older than the Lonza, Waldshut plant which is the "youngest" to have produced an ASL case. I have not had any data of serious Illness attributable to VCM from Latin America. Is there any information available? John Stafford Division Manager Health and Environment Protection ICI Petrochemicals and Plastics Division Bessemer Road Welwyn Garden City ' ENGLAND JS/MM/17 August 1981 twsnan Table Sequence Belglw Canada Czechoslovakia France Germany Italy Japan Norway Sweden UK USA Yugoslavia Incidence of Cases pa (Table 1) Distribution of Cases by Country (Table 2) Pattern of Cases by Factory (Table 3) Latency Periods (Table 4) Annual Geographical Incidence IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION LIVER ANGIOSARCOMA CASES (REVIEW DATA - 17 AUGUST 1981) 1 2-3 4 5-7 8-12 13 14 15 16 17-18 19-23 24 25 26 27 28 29 ASL Case Numbers by year of Death (Table 6) ASL Case Numbers by year of first exposure (Table 7) Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8) USA PVC Producers - Start-up Dates vs ASL Cases (Table 9) Canadian PVC Producers - Start-up Dates vs ASL Cases (Table 10) East European PVC Producers - Start-up Dates vs ASL Cases (Table 11) Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12) South & Central American PVC Producers - Start-Up Dates (Table 13) swsnan 30 31 32 33 34 35 36 37 IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION LIVER Inilourcou Caaea - (Review Dates 17 August 1981) pm i 1 COUNTRY AND REFERENCE NO BELGIUM 2 NAME OR INITIALS ( 3 f DATS OF BIRTH 1 1 4 COMPANY 11 13 6 || 1 1 1 FIRST VC 1 FACTORY 1 EXPOSURE 1 | 1 1 6 DATE OF ACE AT DIAGNOSIS 1 D1ACN0S1S 9 YEARS OF EXPOSURE TO DIAGNOSIS 1 10 < II 1 1 YEARS OF | DATE OF EXPOSURE | DEATH 1 1 1 1 01 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 l 1 1 1 \ X 112.01.13 Selva? 1 JNappe 1 00.07.38 1 00.05.76 1 1 1 1 1 1 1 1 ( { 1 I 1 1 1 1 1 I 1 1 1 1 1 1 ( 1 63 18 1 1 I1 1( 11 1 (1 11 X J_ _L J_ X _L X 17 129.06.76 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 i 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 XJ 12 HISTOLOGICAL CONFIRMATION 11 13 | IA 1 11 1 ESTIMATED | 1 I EXPOSURE I OCCUPATION | LEVEL | | 11 11 11 13 OTHER CAREER HICHL1CKT8 1 1 1 1 I I 1 ( 1 1 16 OTHER COMMENTS Yea High (Autocleaner lOrlller in IHcpttlc Nltl 114 yra (foundry Itn Oct 1974 1938-1968 | 1(2 yre) Iwere nonul. axpoaed to|Polyworker IFanaer I Retired 200 ppai |3 yra 1(13 yra) (Feb 1975 lor 8 hre ) (Work la glaaa (Hoepltallaed per day ( (tnd. 6 cheat- (Hay 1976 and | certainly j (cel tnduetry 1 1 (Coaplate under 300 ppa In,6 to 9a1 | | | | 1 1 1 1 (Clinical and Icarwer detatlal (are given in I paper by eutocleveal 1 (Hublet at el 1968-1972 | 1 |ln Arch. Belg expoaed to| 50-200 PPe| 1 1 (Med. Soc.. (Myg. Med. 8 lira per | ( (Trev. Hed. day to 23a3 | | 1 1 |Leg. (1977 pagea autocleveal I9?2-)4H | 1 1 1601-622 ( expoaed to| 30-200 ppa| 1 I 1 In auto- | 1 1 clave rooal 1974-100 | 1 1 1 ( PI* 1 1973- 50 | 1 1 1 1 PP 1 RETIRED | 1 Feb 1975| 1 1 1 1 1 1 1 1 1 ( 1 ( I 1 1 1 ( I t 1 1 1 1 1 11 ( ( 1 X1 1 ( J 1 1 1 6wsnun IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION LIVER An(loMreMi Caiai " (Review Detet 17 Auguat 1981) All lain uee UK niUa Canada PAT ~ MONTH - TEAR Shea! I ** Data publlehad In Journal of Occ Med 1978 pagaa 338-340 *** Many of dataa altered to fit NIOSH 31/3/77 ltat 10 12 13 1A 13 Pegs 2 18 I I COUNTRY AND REPeREHCE NO NAME OR INITIALS DATE OP BIRTH COWANT FACTORY FIRST VC EXPOSURE DATE OP DIACNOSIS ACE AT DIACNOSIS YEARS OP EXPOSURE TO DIACNOSIS YEARS OT EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS CANADA 01 13.12.13 SRAWIRICAM 1944 1933 41 II 02.09.33 Tea Reactor cleaner Operator Saoker polyaeriaatlon 02 1 03 1 1 1 1 04 1 1 1 1 1 1 05 1 1 1 1 1 08 1 1 1 1 1 07 1 1 1 1 i 08 1 1 1 09 1 08.03.14 1 11 126.08.19 | 11 11 t1 1 105.04.19 | 11 11 11 11 1i (07.05.11 ( (1 11 11 1l 115.12.19 | 11 11 1t 11 109.11.19 | 1t 11 11 11 113.05.20 | 11 1( 1I 119.07.21 | 1943 1957 43 14 14 21.12.37 Tea 11 1 1 1941 1962 42 11 11 11 11 1 1 1945 1967 48 11 11 11 11 11 1 1 1944 1968 57 11 11 11 I1 1 1 1947 1971 51 11 11 11 i1 1 1 1946 1972 S3 11 I1 11 1 1 1 1961 1973 53 i1 11 11 1 1 1946 1974 53 1 11 21 1 20 (23.03.62 ( Tea I ! 11 1 1 11 1 1 l1 1 1 11 1 22 1 22 (21.01.66 ( Tea | 1 11 1 11 1 1 11 1 1 11 1 ( <1 1 24 1 05 (05.07.68 l Yea ( 1 11 1 1 11 1 11 I 11 ( 24 1 23 (10.04.71 | Yea I 1 (1 1 1 i1 1 1 11 1 ( 11 1 26 1 25 124.12.72 ( Tea | 1 (1 1 1 11 1 l 11 1 1 (1 t 12 1 05 (12.06.73 | Tea | 1 11 1 1 11 1 1 11 ( 28 26 (04.09.74 | Tea ( osgsnan Maintenance, Operator lllwrlght, pipefitter Worked overtina Saoker 1 (Operator, (foreaan 1 1 1 (Reactor leleanar 1 1 1 1 J 1 (Oparator, |foreaan, 1 (Worked (overtlaa (Non-gaoker 1 1 (Worked (overtlaa 1 | | ( 1 1 | | Iwatar cooling (Saoker ( 1 1 1 (Reactor (unit 1 J1 11 |Vater cooling (Worked 1 1 1 | Icleaner 1 |unit ( (overtlae (Saoker | ( 1 ( (Reactor Icleaner 1 1 1 I Maintenance, lalllwrlght 1 1 1 (Worked (overtlae | Saoker i ( | | | 1 1 (Reactor Icleaner 1 1 (Machine ehop (operator and ( 1 (Worked (overtlae 1 ( | | 1 Ipoly unit (Saoker | 1 ( I Reactor (cleaner 1 ( |Maintenance (anchlne ahop 11 ) (In plant | 12S yral Saoker| 11 1 (furnace op. 1 pipefitter aatntenance 1 1 (Worked overt la Saoker 1 1 | * Paper by Dr P DELORME In Annalea d'Anatoala pathologlqoe Parla, 197S Vol 23 Ho 2 ppl05-H4 clalaa this case had both a hepatoaa and ASL aiaultaneoualy PLASTICS U!VIS ION IWERtAL CHEMICAL INDUSTRIES LIMITED LIVER Anglosarcaea Cates - (Review Datet 17 August 1981) DAY - MONTH - TEAR Sheet 2 All 4stes use UR syeteB Canada ** Date published In journal of Occ Ned 1978 pages 338-340 ** Many of datea altered to fit N10SH 31/3/77 list Page 3 11 1 |COUNTRY AND I REFERENCE 1 NO 1CANADA 1 10 2 |3 1 11 NAME OR | DATE OP 1 INITIALS I BIRTH 1 1 1 1 1 1 116.05.15 1 1 4 COMPANY 15 | 1 1 1 FACTORY 1 | 1 1 1 i 1 1 6 FIRST VC EXPOSURE 1953 7 DATE OF DIAGNOSIS 1976 8 AGE AT DIAGNOSIS 61 9 YEARS Op EXPOSURE TO DIAGNOSIS 23 10 1 U 1 1 YEARS OF | DATE OF EXPOSURE | DEATH 1 1 1 1 1 14 100.04.77 1 1 12 HISTOLOGICAL CONFIRMATION Yes 13 1 16 1 15 16 J JI 11 ESTIMATED 1 I EXPOSURE | OCCUPATION j OTHER CAREER OTHER cowfEirrs LEVEL 1 | HIGHLIGHTS 11 11 11 1 |Reactur 1 (Furnace op. Ec-aaoker jcleaaer laainteaance. 1 |packaging 9s nan IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION LIVER Angloearcoea Caeca - (Review Datei 17 Auguat 1981) Pa(e 4 11 2 3 4 S6 8 9 10 II 12 13 14 | 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OP DIAGNOSIS AGE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF HISTOLOClCAL DEATH CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION | OTHER CAREER HIGHLIGHTS OTHER COmKNTS CZECHOSLOVAKIA Ot 00.00.28 State Co Novaky OO.OO.S7 00.00.73 66 16 16 00.00.74 Tea 02 00.00.26 State Co Novaky 00.00.51 00.00.66 40 15 15 00.00.66 Yaa 1 ^99Siiyri IMPERIAL CHEHICAL INDUSTRIES LIMITER PLASTICS DIVISION LIVER AnglosercoMa Cate* * (Review Pate: I? August 1981) Prance Sheet I Pag* 5 1 11 1 I2 |3 1 Ii 1COUNTRY AND I NAME OR I DATE OF REFERENCE 1 INITIALS | BIRTH NO 1 11 11 11 1FRANCE 1 1 4 COMPANY 1 |5 6 i 1 1 FIRST VC { FACTORY 1 EXPOSURE 1 1 1 1 DATE OF DIAGNOSIS 8 ACE AT DIAGNOSIS 9 YEARS OF EXPOSURE TO DIAGNOSIS 01 |M 1 1 1 1 1 1 02 IS1M 1 1 1 1 1 1 1 1 03 (NAV 1 1 1 1 1 1 OA |NOR I 1 I 1 1 1 1 1 05 18 1 1 1 1 1 1 1 I 1 | 1 1 1 (15.04.24 1 RP II 1 1 1 1 l (03.06.11 PCUR 1 1 1 1 1 i 1 1 106.01.20 RP 1 1 1 1 1 1 1 127.01.27 PCUR 1 1 1 1 1 1 1 1 129.01.38 PCUR 1 1 1 ( 1 1 1( 1 11 I 11 1 1 _L |RouseI tllon 1 1 1 1 1 Itrtgnoud 1 1 1 1 1 1 1 1 (St Fans ( 1 1 I 1 1 1 |Brlgaoud 1 1 1 1 1 I ( |lrl|iMiN 1 1 1 1 1 J 1I * | 1 1 1 00.01.46 | 18.02.67 | 43 1 06.07.59 15.01.75 63 00.00.46 15.01.75 55 19.10.49 16.01.76 49 18.01.65 13.05.76 38 9 ES9snon _L 21 16 29 26 II 1 10 | II 1 1 YEARS OF I DATE OF EXPOSURE | DEATH 1 I 1 1 19 119.02.67 1 1 1 1 1 ( 12 124.01.75 1 1 1 1 I 1 1 1 29 129.06.75 1 ( 1 ( 1 1 1 26 104.01.76 1 1 1 1 1 1 1 1 11 113.05.76 1 1 1 1 1 1 1 1 1 | ( 1 1 12 HISTOLOGICAL CONFIRMATION Tee Tee (NIOSH no consent) Tee Yes Yes 11 13 1 1* 1 J1 I1 ESTIMATED 1 | EXFOSUEE | OCCUPATION | LEVEL 1 ( 11 11 11 >5 OTHER CAREER HIGHLIGHTS 1 1 1 | | ( J 1 1 16 OTHER COWENTS High High High High High liuKoeUvt 1 |Ref. Revler at (worker and 1 Iclesner 1 |el Arch. Hal. |Prof. 1 30 n* 119 yra 1 |3 Nov 75 11 |p 171*177 1 1 |2 yre on J 1 lltallan J 1 |Ref. jeonoser lorlgln |C Bonneton at (10 jrrs on Ipolynsr- 1 1 |el "Nourells jpreaae llsatlon 1 |**dlcal*' 11 |5 Nov 1977 11 Ip 735 11 1 11 1 IPolyworker |VCM productlonIRef. Raty at (10 yra aa 116 yra |al Arch. MI. (autoclave lltallan POH |Prof. 1 37 n* Iclesner ISheoherd. |6 June 7f |Compounding (Sawyer, Mason |p 551-555 P yra 1 1 11 1 1 I Honoser 1 1 1 1 (production 1 1 (worker 1 1 18 vra .1 1 (PVC 1 1 (filtration 1 1 (18 yra 1 1 1 1 J 11 1 IPolyworker (l)Thoracoto(iy |lef. V Coedere III yra |9th Feb 1970 |at el 'Beaalne 1 (costal (dee hoaplteui 1 |angioserco*ti |10 Septsubrs 1 |2)Sclntlgraphy|1976 I (found ASL (Previously had 1 (3)Hae*orrha.e (bone 1 (fro* ASL |anglosarco*a* 1 |4)R!ght |Alao 1 IHepatectony |PILlchowekl at |1 |el "La Nouvell 11 11 1J (Press* Medical |7th July 1979 IPaue 2485 IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION LIVER Anglo ear cone Caeee - (Review Date: 17 August 1981) Prance Sheet 2 Pi| 6 10 12 1) 14 IS 16 COUNTRY AND REFERENCE NO NAME OR DATE OP INITIALS BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIACNOSIS YEARS OP DATE OP EXPOSURE DEATH HtSTOLOCtCAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER MICHLICKTS OTHER COIMENTS PRANCE 06 Pe 1 07 |GIR 1 1 1 1 1 08 09 RPX 14.04.34 PCUK Brlgfwud 01.03.Si 12.06.76 42 11 126.04.27 1 RP 11 11 11 11 1J 11 1 1 1 I St Auban | 01.07.SO | After 1 49 | 26 11 death 1 1 11 NIOSH 1 1 11 ( aaya 1 1 i1 | 00.07.76 1 1 1L 1 _l___ 1 01.04.34 Soivay Tavaux 23.03.S7 03.I2.7S 42 19 06.10.14 RP St Pone 10.01.48 26.04.76 62 28 13 11.09.76 (N10SH ajre 12.09.76) Yea Moderate <1958-1960) 2 yra filtration 10-11 yr polyworker and worka labt lhta nan had AOL prior to AS. Ann. da Hal. Prof. July *77 p 64S A 6. AOL waa found In 1971 five yra before ASL 1 11 t1 1 1 | 22 102.07.76 1 Tea 1 High (Plant fore- (1972-6 adnln (Died of 1 1 1 (NIOSH no 1 |nan in (action In leaptIcaanta 1 1 1 conaent) 1 (polyner-- (St Auban (Snail liver 11 \ (leatlon 1 llealon found 1 11 11 ( lafter autopay 1 1| _l 1 J J 19 30.01.77 Tea Moderate 6 yra packer 6 autoclave clnr 14 yra autoclave worker Had been tunual worker prevlouely 28 16.12.77 Yea High Polyner- 10 yra In laatlon eulphurlc operator, acid factory, autocleaner, atorekeeper 4 autoclave general ealntenance aervtcea Operated 4.76 for renoval of tunour Iron liver and died after eecond eurglcal operation for blllo bronchial f latula W9SMU0 _J____________L M* ad a 22 33 Q ill ba- sI- s sV g 52 3" 2>SM e*.wge2 ns1 * n n 9<0 SU 35 ^9 a5HI#*^O4- KI cwb aQa 9 499 9m O--_*fha jM;1uIes0BUes9--f9a----tr #fwoa4 fcssa a 9I ib 1 --15 8e 8u.5>. * a tt mt s-ris a 2 8.5 tiS I 0 fa* a n 9 9 9rs t.* fafsa **va.u--fa^mc**) Us toI 0so O4os|Mi^*f9aa0 *3e*O-N *w9v0ei. m b 9 w fa k y _K (i c 9e 5R ua *2 & ma S.S58 8 t!t! S. Ml b b> bs.. le.iSar C 33 cn cvvnii ss si cs LIVER A nglosarccaa Caaea (R eview O c ta l 17 August 1981)" 55 IS M > W a IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION LIVER Angloearcona Cases (Review Date: 17 August 1981) Ceraany Sheet 1 Page 0 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COIVANY GERMANY 01 00.00.30 Oynanlt 02 1 03 1 1 1 1 1 1 1 \ 1 1 1 1 1 1 1 1 1 1 1 04 1 1 00.00.31 Djfiualt 11 100.00.30 | Dynaalt 11 11 11 11 11 11 11 11 11 11 1t 11 11 11 11 11 11 11 100.00.30 | Uacker 11 10 12 I) 1* is 16 X I FIRST VC DATE OF ACE AT YEARS OF YEARS OF DATE OF HISTOLOGICAL ESTIMATED 1 OTHER OTHER FACTORY EXPOSURE DIAGNOSIS DIAGNOSIS EXPOSURE TO EXPOSURE DEATH CONFIRMATION EXPOSURE | OCCUPATION CAREER COMENTS Troladorf 0I.10.S6 19.09.68 38 DIAGNOSIS 12 LEVEL | HICHL1GHTS _________ 1__________ 1 I I 12 2S.0I.69 Yea (NIOSH) (Polyvorker J_________ I Troladorf 14.IO.S7 23.09.70 39 13 14.12.71 Yaa (NIOSH) (Polyworfcar I 11 IRhelnfel -I 09.06.52 1 00.03.73 |den 1 11 I1 11 11 1 1 1 1 1 1 1 43 1 11 1 21 1 16 110.10.73 (tea (NIOSH) | 1 11 | I 11 f 1 11 | 1 11 1 1 11 1 11 | PI Hint 1 Ipaatlclde 1 (aerosol canal (with VC 1 11 1 1 (Reported under |non polymer|laatloa (workers In INIOSK Hat of (31.3.77. 1 11 1 11 11 I 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 11 11 11 11 11 11 11 11 11 11 11 1 1 1 1 1 1 1 1 1 1 1 (This of couraa (la strictly (correct. |However I (wonder (whether this (nan had high (exposure to (VCM In hla (can filling (operation! 11 1 11 11 1 1 1 llurg- Ihausen 1 16.04.57 | 26.11.74 1 1 \ 1 44 1 11 1I 1 1 17 1 17 (25.11.74 |Yea (NIOSH) 1200-500 ppu(Polyvorker 411958 was (Clinical 1 11 |but high |tenpurary tautoclaaner (details in for I yr I paper by 9S9snan autecleaneti 1 I I 1 I 1 I 1 I 1 1 I |Cokel at al IVIrchowe Arch |A Path 1976 |372 p 195-203 1 I 1 1 1 I I 1 I I J____________ IMPERIAL CHEMICAL INDUSTRIES UNITED PLASTICS DIVISION LIVER Angloearcona Caaea - (Review Detei 17 August 198!) Carnany Sheet 1 Page 9 COUNTRY AND REFERENCE NO NAME OR INtTIALS DATE OP S1RTH GERMANY OS (NIOSII glvee ae Caee 06) 00.00.36 COMPANY Kneehet FIRST VC FACTORY EXPOSURE Frankfurt 02.04.60 DATE OF DIAGNOSIS 10.12.7) ACE AT DIAGNOSIS 38 YEARS OF EXPOSURE TO DIAGNOSIS 13 10 12 YEARS OF EXPOSURE DATE OF DEATH HISTOLOCICAL CONFIRMATION 03 16.12.74 Yae (NIOSH) 1 13 1 1* 1 ESTIMATED 1 EXPOSURE I OCCUPATION LEVEL 1 1 1 1 1 |BC Chenle (eaye fchentetry (laboratories |ln the (Techno(logical (Research IDepertnent" I(NIOSH eaye (aeeletant Ifactory Icheelat (which nay be I wrong (tranalatlon) 1 15 OTHER CAREER HIGHLIGHTS 1 | 16 1 1 I OTHER | COMMENTS 1 1 (Cool 1 need (Reported under |-ton-polywer(iaatlon |workers In (YIOSH Hat of III.3.77 and 11.78. I don't |:hlak thla la |t correct I :laeetflcatIon 1 by NIOSH. The | can nay have (been Involved (In VCH Ipolynerlaatlon (In pilot plant (or In aaln 06 (NIOSII glvee ea Caee OS) 07 00.00.32 Lonce Ualdehut 16.12.62 00.00.7S 43 00.00.26 Hacker 8ur*haueen 15.04.54 12.11.75 49 13 12 09.01.75 Tee 21 21 13.11.75 Yea (NIOSH eeye 12) 08 00.00.17 Dynanlt Trotadorf 19.07.54 06.04.75 58 21 22 25.12.75 Tee IPVC - HamrIfacture (Sblft Leader I J___________ |PVC Nanu|lecture end |ell work Itncl autoleleanlng |12 yre 1(1954-66) (Forenan Tech |Dev g yre 1(1967-1975) I (Folyworker I isosnun i I IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION LIVER Angloearcoea Case* - (Review Date! 17 August 198I) Ceresny Sheet 3 Page 10 10 12 13 14 IS 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATS OP BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS TEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMENTS GERMANY 09 00.00.34 CUH Marl 20.02.61 16.06.76 41 1 1 10 1 |(NIOSH gives| I a a Case 11)1 1 1 1 1 1 1 1 1 II 1 (NIOSH give* aa Case 10) 11 100.00.16 | CUH 11 1I 11 11 11 11 11 1i 100.00.29 | Hacker 1 (Marl 1 1 1 1 1 1 1 1 1 | Burg- haueen 11 1 01.01.61 | 00.01.77 11 11 11 11 11 11 11 |1 11 1 10.10.55 | 28.06.77 1 1 1 1 1 1 1 1 1 | 1 1 40 47 IS I) 24.03.78 Taa Nigh peek* 12 yra poly worker incl I7Z autocleve cleaning Control rooa I yr 1 11 11 1 16 1 10 107.03.77 1 Tea IHigh peaks |10 yra po!y-| 1 11 1 {worker lncl | 1 11 1 |17X auto- | 1 11 1 |clava | 1 t1 1 {cleaning | 1 11 11 1 1 11 11 1 1 11 11 1 1 1| 11 1 1 11 11 1 22 1 22 128.06.77 1 Tea 1 HlRh |3 yra auto- | clave cleaner 19 yra filter operator 10/78 Confirmed Average exposure first yre ISO ppe, occ 1000 ppa. Next 3 yre av, 75 ppe. Laat. yr av 35 ppe (Average | (exposure first| |9 yre 150 ppa.l |oec 1000 ppa.l |Leet yr av | 173 ppe. CUH | jletter of | 121.04.78 { 1 11 11 00.00.30 Oynaelt Trolsdorf 00.00.61 00.10.77 39 16 07.10.77 Tee PVC Manu facture Autoclave worker for 6 yre 8$9SUUn IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION Ctnwf 8heet 4 Pag* I LIVER Anglaaarcoea Clitl - (Review Data! August 1981) 11 12 13 i--------*-- ~--3--i 6 |COUNTRY AND I REFERENCE 1 NAME OR | DATE OF INITIALS | BIRTH COMPANY i i | FACTORY FIRST VC EXPOSURE | NO 1 1 GERMANY 1 1 7 DATE OF DIAGNOSIS a AGE AT DIAGNOSIS 9 10 1 11 YEARS OF YEARS OF | DATE OF EXPOSURE TO EXPOSURE | DEATH DIAGNOSIS 1 12 HISTOLOGICAL CONFIRMATION 13 1 u 1 is 1 16 l ESTIMATED 1 1 | OTHER | OTHER EXPOSURE | OCCUPATION | CAREER I COMMENTS LEVEL 1 | HIGHLIGHTS 1 1J 1 1 | | 1 1 1 13 100.00.14 Lomi IWaldehut 00.00.60 08.04.78 64 14 U 119.06.78 Tea 11 |F U Beat | 11 11 (latter of | 11 11 |J0th June | 11 11 | inclosing data) 11 11 1Iroe | 11 11 Mr 1 A Frladell I1 11 i >f BG Cheaala 1 1 >4 1 1 Not aa 11 |F U Beat | 11 Angtoaarcoea 11 Hatter of | 11 11 11 1i (10th June | (enclosing datal 11 11 (Iron | 1I 11 |I A Frtedel of| 11 11 |BC Chenle | 11 11 (withdrawing { 1 11 Ithla case 1 1 IS 100.00.29 Hacker 1Bnrghauee 19.10.S3 09.10.78 49 25 25 123.10.78 Yea 1 I Autoclave 1 IAngtoaarcoea | 11 (cleaner and 1 (conftreed | |(NI0SH glvea 1 1 jworker. i 109/79. Soee | |thla aa 1 1 IDrler i (detail of thlal ICaae 13) 1 1 (operator. i |4 also cases 1 11 (Later ehlft i (9. 13. IS. 16 | 11 11 |leader 1 i i |4 17 given In | |N>N Report forj 11 1i 11978 1 ( 16 100.00.23 Dynaatt (Troledorf 10.01.55 07.08.78 ss 23 20 107.08.78 Yee Nigh I Autoclave i lAnglosarcona | 11 ASL aad I worker till i (confirmed. | 11 11 Hepatocellular Care lama (1964. i jLeader and i (fall details | (of lllnaaa j 11 {eater i (tinea March | 11 i (1973 given in 1 11 1i (NRH Had (nap | 1 17 100.00.37 Dynastt 1 (Troladorf 6l.li.6l Vi-- ---------- 14.08.78 16 II 1*8.64.76 Yaa 1i nigh (Autoclave 1 No IReo for 1978. 1 |Angloaarcoea | KNIOSH glvea 1 1 |worker 1 (conflrned. | |aa Case IS) 1 I 11 (Annual report | 1 11 (of the North | 1 1 1 11 (1 (Rhine llleatphalla | | 11 i1 11 11 (Medical | (Inspectorate 1 11 11 (for 1978 | 1 1 1 11 11 (pages 347-377 | (glvea full | 11 11 1( 1 1 |details. Vinyl| (chloride | 11 11 11 6S9SUHn 11 (1 11 Idiacasa (dlagnoaad (02-02-73. | | | 11 11 11 11 11 1| 11 1( 1 1 (Oesophageal 1 (varices. | (probably aero 1 1J ______________ 1 1_______________ 1J ioateolvule. i ~At the NIOSH/OSHA/NIEHS Synpoilua In Betheada 10/21 Nirch jlM Sr Ueber eald there war* now 17 coiflraed caaaa In Cenieny. I therefore preaiaaed cease 13 and U vara now histologically conflr*i'<) On 30th Jun* 1980 I received froe Dr F II Beat of 1C1 Europe data originating frod Mr 1 A Frtedel of BG Cheele who ataterf that rate 13 waa a confirmed ASL aitd cnee 14 watt not an ARI.. C.ibo 14 IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION LIVER Angioitrem Ciiei - (Review Detei 17 August 1981) 1 COUNTRY AND REFERENCE NO GERMANY 18 19 1 2 13 1 1 NAME OR ) DATE OP INITIALS I RIRTH 1 1 1 1 100.00.13 1 1 1 (00.00.25 1 A COWANY I 15 1 16 11 11 1 1 FIRST VC | FACTORY | EXPOSURE 11 11 11 11 Hoechet Dynaalt (Condor! | 00.00.55 11 11 11 (Troledorf ( 18.10.54 1 DATE OF DIAGNOSIS 25.12.79 00.08.79 8 AGE AT DIAGNOSIS 9 YEARS OF EXPOSURE TO DIAGNOSIS 1 10 1 II 1 1 YEARS OF I DATE OF EXPOSURE | DEATH 1 1 1 1 66 24 21 (25.12.79 1 1 1 54 19 18 I 22.2.80 |(Figure given I by Mr Frtedel 1 Ipreeu&ebly le.rly Idlagnoili In J1974T) J____________ I 12 HISTOLOCICAL CONFIRMATION Yee Ten 1 13 1 14 1 1 ESTIMATED 1 EXPOSURE I OCCUPATION LEVEL 1 1 i |Autoclave (Worker 1 1 |Autoclave |Worker Carnally Sheet 5 fi| 12 15 OTHER CAREER HIGHLIGHTS l 1 | 1 1 1 1 | 1 1 1 | 1 1 1 16 OTHER COMMENTS t ! I 099snan 1I I 12 <3 11 1I COUNTRY AND | NAME OR | DATE OF REFERENCE i INITIALS I BIRTH NO | 1 11 ITALY 1 1 1 01 (On NIOSH suppleenter? list) 02 03 04 I | | | | 1 1 1 | 1 1 1 { 1 { 1 1 1 1 | BP 1 { 1 1 1 1 1 1 1 1 (15.06.34 1 1 1 1 1 1 1 113.11.29 1 1 1 114.03.20 1 1 1 1 i 1 120.07.37 1 1 { I 1 1 1 1 1 I 1i 11 1I 11 4 CO^ffAMY < 13 1 { 1 1 FACTORY 1 { 1 IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION LIVER Anglo*m<Mi Caaea - (Ravlaw Datai 17 Auguat 1981) Should thla caaa ba raaoved (toa tha Halt MIOSH have it on chair aupplaawntary Hat rotating to JS I/S/77 Pago 13 1 91 7 1 1 FIRST VC { DATE OF EXPOSURE | DIAGNOSIS 1 1 1 1 8 1 9 1 to 1 11 1 1 ACE AT j TEARS OF | TEARS OF ( DATS OF DIAGNOSIS | EXPOSURE TO | EXPOSURE 1 OEATH | DIAGNOSIS 1 1 1 1 12 HISTOLOGICAL CONFIRMATION 11 1 13 1 14 | 15 i 11 1 11 BST1MATBD i 1 EXPOSURE { OCCUPATION | OTHER CAREER 1 { | LEVEL 1 1 HIGHLIGHTS 1 JL_ 11 J 1 t1 1 16 OTHER COMMENTS t 1 1 1 1 1 1 I 1 1 00.00.65 | 19.04.71 11 11 {1 I1 11 I1 ( Montadlaon1Porto 1 00.00.57 | 13.12.72 |Hargbara I1 Bolvay I | FarraraT 1 00.01.53 | 10.07.75 11 11 11 11 11 1 SC RavannalRavanne 1 00.04.59 | 00.01.SI 11 i1 11 1I 11 11 11 1\ 11 11 36 | 06 43 t 13 55 | 22 43 1 21 1 03 116.04.71 1 1 { 1 I 1 1 t 06 {00.12.72 1 { ( 21 110.07.75 1 { 1 1 t 1 1 21 (30.03.81 1 1 1 1 I 1 1 1 l 1 TYaa Yaa Taa Tat |PVC gag jaxtruder | 1 11 I1 1t 11 JL l1 {Polyworker | 11 High JL. 11 |Autoclaanar | {8 yra | |Autoclaa | {oparator | 112 yra 1 JL. It 12 yra - II yr- 1 Vary (Ugh INsnoan | {oparator | 3 yra Madlua 4 yra Low 11 (20 yra - 1 (Autoclave | {oparator 6 j {othar dutlaaj (In auapana- | |ion poljfMr-l llaatlon. | {Prlnary tiaaurl |aay hava been | pericarditis. {Not hoao- Igaoaoua with lothar caaea J 1 1 1t J 1 |*F0A at al 1 {pap*** at |Dubrovnik iauggaat 1 { 1 1 {1 11 11 1{ 11 1 11 11 11 1 1 1 _L 1 1 1 1 1 1 1 _L |Araa Forenanl | in aana Dept| lalnca 1975. | _L JL { 1 1 1 1 1 1 1 L99snyn I IMPERIAL CHEMICAL INDUSTRIES LIMITED FUSTICS DIVISION LIVER AnglaurcoM Casea - (Review Date: 17 Auguat 1981) fill 14 11 12 11 |3 | 4 11 151 6 1 11 11 1 11 i1 |COUNTRY AND i NAME 01 | DATS OP 1 1 1 FIRST'VC I REFERENCE I INITIALS | BIRTH I COIVANY I FACTORY | EXPOSURE | NO 1 11 i1 1 11 11 1 JAPAN 1 I 11 11 11 11 1 11 11 1 01 ITonoJi 101.08.22 (Mitsui |Nagoya | 00.04.53 IMorl 1 IToatau 1 1 1 1 I (no eoaantl | 1 1 |by Jap PVC 1 1 1 1 lAaaoc) 1 1 1 11 11 1 11 11 1 11 11 I 11 11 1 1 1 1 | 02 ISO 1 1 1 11 11 11 11 102*08.39 1 11 11 1I 11 11 11 11 1 1 00.11.58 1t 11 11 1 11 11 J JJ JL DATE OF DIAGNOSIS 24.t0.75 10.06.76 B ACE AT DIAGNOSIS 53 37 CASKS NOT YET CONFIRMED 9 YEARS OF EXPOSURE TO DIAGNOSIS 22 17 1 1( 10 1 11 12 1 13 1 14 I 1 J_______________ 1 I 11 YEARS OF | DATE OP KISTOLOCICAL | ESTIMATED 1 EXPOSURE | DEATH CONFIRMATION | EXPOSURE | OCCUPATION 1 | LEVEL 1 1 11 1 11 1 11 1 13 (24.10.75 Tea 1( (PVC Aaaoc |I3 yre auto- 1 leaps not | clave 1 (known. (cleaner 1 |* Japan (1964 - 1 (Tinea (assigned to 1 (Indicated (different 1 (on 25.|0.75|work alnca 1 laapoauraa Iliad 111 1 ( 1 1 1 13 (10.08.76 loften at Ihealth 13000 ppa up| (to 1974 1 11 11 Tae |Not known (In polyner- 1 1 1 1 J _L 1 ileatloa work 1 (Including 1 (autoclave 1 Iclaaning 11 ( 15 1 U J ( OTHER | OTHER CAREER | COMMENTS HIGHLIGHTS 1 1 1 1 1 IJapan Tlaaa 125.10.75 t IJapanaaa PVC lAaaoc letter (of 31.03.78 1 1 1 1 1 I 1 IJapanaaa PVC |Aaaoclatlon lletter of (31.03.78 I 1 1 1 1 1 1 ( 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1Sh1suo (Sato 1 | | 11 11 11 11 1 IShlgeo 1 | (Tanaka | 11 11 11 11 11 11 IKituystbl | (Ono | 11 11 11 1I I Sub- |Nagoya 1 contractor! ( to Mltaul | I Toatau | 11 1I L_____________ 1 1 Mltaul |Nagoya I Toatau 1 I ( 11 11 11 1 1 I Mltaul 1 1 I Nagoya 1 Toatau 1 11 1_____________ J _1_ 1953 1 1 1 1 1 1 ( 1 | Nov 196B 1 1 1 1 1 1 1 I Dec J 967 1 1 1 1 1 1 1 1 1 1 ( | 1 1 ( 1 1 | 1 1 1 1 1 43 16 47 Z99snan 1 1 1 1 1 1 1 1 | 1 1 1 1 ( 1 1 1 1 1 1 1 11 11 11 11 11 (I 11 114.01.69 ( 11 11 11 11 11 11 11 | Dec 1967| 11 1i 11 11 1 (Reactor Icleaner (1964-1974 1 1 1 i 1 1 i 1 1 1 | j | 1 1 1 1 1 1 1 1 1 11 11 11 11 11 1l 1 I I 1 | | | ( | | | | | | I 1 | | | | _J__ 11 IPra-canceroua | (disorder of | Hirer 1 IJapan Tinea | 125.10.75 not | (conflrnad by ( (Jao PVC Aaaoc 1 IJapan Tinea 1 127.10.75 (eonel | figures | (uncertain bad | (print). Not | |conflrned by | |Jap PVC Aaaoc 1 11 |Japan Tinea | |27.I0.75. Not| (confined by | |Jp PVC Aaaoc | ____ 1 1 I IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION LIVER Anglosarcou Case* - (Review Date) 17 August 1981) Pag# 19 10 12 13 14 13 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH CO(TANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HICHLICHTS OTHER COMMENTS NORWAY 01 AH 23.12.13 Norsk Neroya 00.03.30 21.12.71 56 22 21 04.01.72 Yes High Foreean A | Hydro Autoclave j supervisor | 1 1 1 1 1 1 1 1 1 1 1 1 {Confirmed By |Dr ThilalEvanson of NH. |At APME Mtg of |9 June 1978 |Nr P Rangnes latated that AH (bad been a (aeaber of a (atart-up tea*. |VCH 4 PVC wars laade In aaae (building. The |VCH was aada Ifroe acetyiaoa ian 4 IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION LIVER Angiosarcoea Cases - (Review Dates 17 August 1991) Pag* 16 10 12 13 14 13 16 COUNTRT AMD REFERENCE NO NAME OR INITIALS DATE OP BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DlACNOStS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER C04R4KNT9 SWEDEN 01 MJ 23.06,27 lesnorl Suodavail 14.08.51 20.10.70 43 19 IS 20.10.70 Ysa Polyworker 02 SL 27.11.11 Keaanord Suadsvall 00.01.45 00.08.72 61 27 27 16.08.72 Ysa High VCM production \ 03 | ME 1 1 04 IAL 1 1 1 1 1 1 1 1 1 1 ! 110.06.10 1 1 116.11.14 1 1 1 1 1 1 1 1 1 1 1 1 11 Eewanord Keaanord 1 |SundavallJ 00.05.47 1 1 |Sundsvall| 00.00.46 11 11 11 11 11 11 11 11 11 11 11 11 J J1 18.03,76 12.05.77 1 | 1 I | ( 1 1 1 I 1 ! 1 1 1 1 1 1 63 62 29 31 - 1 1 21 | 1 1 31 1 1 1 1 1 J 1 1 1 i 1 1 i_____ 1t 119.03.76 1 11 11 M2.05.77 1 11 11 11 1I 11 11 11 11 11 11 11 11 _J J__ Yaa Tea 1 1 High 1 1 1 High 1 i 1 1 1 1 1 1 1 1 1 1 1 11 |Polyworker | 11 I 11946-1938 i | Ipolywer- | lisatlon | (worker (12 | lyra) 6 1958-1 |I977 foreaani 1(19 yra) 1 1 ( 11 I1 1t 11 11 !1 Hr SJo*lln's lsttar of 28 March 1978 coaflras SL was a aonoaer worker who was heavily posed, probably even ore so than a NfH 1 reactor cleaner 1 1 1 1 |Ib first 12 lyra of (aaployaent harf| |been heavily laspoasd. In (1974, liver (abnormality land necrosis idisgnosed. IDate confirmed! |ln Dr D Syren lletter 18.8.77| 11o CKFIC 1 HJ9SI nun _J____________L IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION LIVEK AngloMrcoM Caaos - (Review Datei 17 August 198)) UC 8Wt I Pig* II jl l 1 12 11 |3 1 4 1 1| 11 (COUNTRY AND ) NAME OR I DATE OP { REFERENCE I INITIALS I BIRTH COMPANY I NO 1 1 11 I |UK 1 1 1 01 |WJ t (20.04.01 ICI 11 11 11 11 11 t1 1I 1 03 1 |AIW 1 102.06.37 BP 11 1I { 04 1 |JSS 1 1 (23.06.20 ICI 1( 1 11 11 11 11 11 1 11 i( 11 \I iI 11 11 15| 6 11 11 1 1 FIRST VC ( FACTORY | EXPOSURE t1 11 )1 11 11 (Hlllhoueel 04.04.44 11 (1 11 11 11 11 1 1 (Berry 1 1 | 00.02.66 1I 11 11 11 (Hlilhoueet 26.04.34 1| 11 11 11 11 11 11 11 11 11 11 11 11 11 1 7| 1 1 DATE OF | DIAGNOSIS | 1 1 1 1 1 03.12.72 | (Pox & | Coliter | paper aaya) 23.12.72) | 1 00.12.74 1 1 | 1 1 1 1 00.06.79 | 1 I 1 ( 1 1 1 1 1 t 1 ( 1 8 ACE AT DIAGNOSIS 71 37 59 11 9 | 10 1 11 1 12 11 11 YEARS OP | YEARS OP | DATE OF | HISTOLOGICAL EXPOSURE TO ( EXPOSURE I DEATH I CONFIRMATION DIAGNOSIS (1 11 11 11 11 28 I 22 103.12.72 1 Tee l(Pox A 1 (Collier 1 |pepY 1 (eye 1 (23.12.72)1 11 11 11 09 1 3.5 (24.12.74 1 Tee (1 11 11 1( 25 1 18 112.10.79 1 Tee 11 11 (1 11 11 11 11 11 11 i1 11 11 I1 ( 11 1 13 1 M 1 13 1 14 11 1 11 ESTIMATED 1 ( EXPOSURE | OCCUPATION | OTHER CAREER 1 | OTHER | COMMENTS LEVEL 1 ( HIGHLIGHTS I J_______________ 1 (1 1 1 500 ppa 1 1 (1944-7 VCM 1 1 ( 1 ( 1 (1947-8 Drier! (1948-61 1 (Autoclave ( (operator 1 11961-66 1 1 1 1 ( ( |Prior 1 1 11 1 High Medium 1 (Autoclave (cleaner i 1 ( (54-5 1 1 ( 1 1 (Pra-war flah 1 (Eapoeure (Halted to 12.66 - 9.69 1 1 1 high (Begging Inacker 1 (Plant (1939-45 any 1 (55-6 (vehicle 1 (Drier Plant 1Maintenance 1 (56-58 (Autoclave (1945-54 1 Iflah nacker _l (worker 1 1 (58-61 1 IChargehend 1 1 (Drier 1 1 (Plant (61-72 | Poraaan ( ( ( 1 1 1 |C 2/3 Plant 1 1 599^1ian IMPERIAL CHEMICAL INDUSTR1ES LIMITED PLASTICS DIVISION Ml Bhaet 2 fl|4 IS LIVED AugIonarcou Cam (Review Date* 17 Au|uat 1991) i1 -----;----1 i l --r~ 1 ~i--5-- 1 6 --------- 7-------I1 4 ----------- j----------1 l || 1| || (COUNTRY AND | NAME 01 l DATE OP 1 1 1 FIRST VC DATE OP i ACE AT 1 YEARS OP I REFERENCE | INITIALS l irm i COIffANY | FACTORY 1 EXPOSURE 1 DIAGNOSIS i DIAGNOSIS | EXPOSURE TO t NO 1 || 1i | | DIAGNOSIS (IIK 1 l 1 1i 1 l os |JK |30.03.16 1 IP 1 tarry i 09.01.SI 00.10.79 65 1 29 --is--1--n-- i TEARS OP I DATE OP EXPOSURE | DEATH 1 1 21 119.11.79 ------------n-- HISTOLOGICAL CONFIRMATION --n-- i n i i ESTIMATED EXPOSURE I OCCUPATION LEVEL 1 1 11951-32 1 11 1 11 (Polycloaner 1 11 1 11 1 1 II932-55 1 11 1i 11 |Later 1 11 1 11 1i 1 1 1 1 11953-60 11 1Polyfloor 1 11 1 11 11960-64 1 11 i 11 1 1 1 1 1I 11 11 Italy (Chargehand 11964-70 11 1 11 (Charging 11 11 (operator I 11 1 11 (1970-72 11 11 (Drier I 06 1 1 ICEP 1931 IP 1 1 1 tarry 1962 09.01.90 49/9 1 | IS 1 1 12 (09.01.90 (operator (7 yra 1 11 |Poly Floor i1 11 lOparator 11 11 (5 yra 11 11 (Craaaar oft 1 1 07 |RB 1920 IP 1 1 tarry 1963 | 60 1 17 (13.06.90 IPolv Floor (Polycleaoer 11 11 (1963-5 11 11 (Recovery 11 11 11965-1971 11 11 1 11 11 1i 11 11 11 11 11 11 11 1 11 11 1 11 1i 1 1 11 1 11 1i 1 1 .1 11 1i 1 11 1 1 11 1i 1 1 11 1i 1 1 11 1i 1 1 11 1i 1 1 11 1i 1 1 11 1i 1 1 (1 1i 1 i 11 1i 1 I 11 1i 1 | 1 1 1 1 ( 1 i 1 1 1 1 11 11 11 1 I 1 11 1 11 11 11 I1 11 I 1 1 gags nan 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 11 1 11 ( 11 ( 1 1 1 1 1 1 1 1 1 -1 1 1 1 1 1 ( 1 1 1 I I1 1 11 1 11 1 1 I 11 1i 1 1 i 1 1 l 11 1 1 1 i l J_ _L 1 L __L 11 _L .1 _L 1 -L l ... ... f5--------- "j------------- 16----------- OTHER CAREER ICHLICHTS 1 | OTHER 1 | COMMENTS 1 1 1 11 1 1 1 1 11 1 1 ( (I 1 ( 1 1 1 1 1 1 1 ( 1 1 (Death (attributable (to VCM (Angloeercoaa (incidental Iflndtna (In their (supplementary (llat HIOSH (are atlU (quoting Caaa |02 frou 10C0 (which haa been| Idlacounted In (the UK. IOCO (apread many Ipolynara (Including PVC |onto fabrlca. (The UK (Government | Medical | Advisory (Service elao (know of two (further con|(iiud ASL Icaaes In (plastics (fabrication (workere but lit la dubious |whether they (ever handled (i'vr I IMPERIAL CHEMICAL INDUSTRIES LIMITED PI-ASTICS DIVISION LIVER AngIa*<rcM( Case* - (Review Date! 17 August 1981) *UR of dstee DAY - MONTH - YEAR USA Shoot I Pago 19 ( 1( 1 12 13 1 4 1s 1 |1 11 COUNTRY AMD I NAME OR | DATE OP 1 REFERENCE | INITIALS | BIRTH 1 NO 1 1 COSPANY 1 1 | FACTORY 1 1 |I USA 1 1 11 1( 1 01 (Earl 1 117.10.23 1 RFC 1 ILouls- (Parks I villa 11 i( 11 11 1( 1 02 J 1 (19.06.33 RFC 1 I LouieI villa I1 11 11 1 03 (Edward (25.05.15 RPC 1 ILouls- IDlnwtddla I villa 11 1( 1 04 1 1 (15.01.24 BFG 1 (Louis- I villa 11 1 OS 1 ( ( 1 06 (Ray 125.01.12 RFC 123.11.28 RPC 1 (Louie- I villa 1 1 (Louie- (Austin I villa (Jones? 1 11 1i 11 11 1 07 | Charles 103.05.22 ucc 1 IS Chari*- IT Sun I at on JJ 1 617 | 1 FIRST VC 1 DATE OF EXPOSURE 1 DtACNOS19 a ACE AT DIAGNOSIS | 09.12.48 03.03.73 49 15.11.55 00.05.70 37 28.11.45 19.12.73 SB 06.07.52 19.08.67 43 19.06.44 09.04.64 52 17.01.62 1 00.02.74 1 1 27.08.44 00.00.68 1 1 | 1 1 _L 45 45 08 06.05.20 Goodyear Niagara 07.10.46 00.08.61 41 1 9 10 1 II 1 12 TEARS OF EXPOSURE TO 1 TEARS OF | DATE OF EXPOSURE I DEATH HISTOLOGICAL CONFIRMATION D1ACN0S19 1 1 1 1 1 24 21 103.03.73 Yaa 1 1 1 1 1 1 1 14 13 127.09.71 Tea ((NIOSU Isays |28.09.71)| , J_______L 1 28 28 119.12.73 Tea 1 1 1 1 15 15 107.01.68 Tea 1 1 1 20 20 109.04.64 Tea 1 1 1 12 12 124.07.75 Tea 1 1 1 1 1 1 1 24 17 123.03.68 Yaa 1 _L J 15 15 29.08.61 Too 99SV "Wl 1i 1I 13 ( 14 1 13 I 16 ( 11 11 11 i 1 ESTIMATED 1 | EXPOSURE | OCCUPATION j OTHER CAREER < OTHER | ( COMMENTS | LEVEL 1 | HIGHLICHTS 11 1 1 1( 1 1 1 IRlstory given IRolllng Stone | 1 |ln Annala NT |Art | |Pot Cleaner IACAD SCIENCES (Ref l NY Acad | ((Block Jaaa (Vol 329 (1979)(of Sc Syap ( | 1974) p 53 (page 190 In |1974 | ( |Faper by I Also Block I 1 |R R Cottlne o(|Jaea 1.7.74 | 1 |0SKA Ip 33 | 11 1 1 1( (Pot Cleaner 1 1 (Ref 1 1 | |(Cf Block) 1 lAlso Block | 11 (JAMA I.7.74 | 11 (P 53 | 11 t1 (Pot Cleaner (Loulavllle 1 1 (tef 1 1 1 | |(Cf Block) (Courier |Also Block | 1 IJournal t 1 1 102-09-80 1 1 11 (Pot Cleaner 1 1 (Ref 1 1 | |(Cf Block) 1 |Also Block | i1 1 1 i1 (Pot Cleaner 1 1 (Ref 1 |(Cf Block) 1 (Also Block J___ ____ J__________ 1 1 | | 1 1 IDS Air Force! 1 (Pot Cleaner |{Cf Block) 1 1 1 ( 11 |Ref 1 + | |Louisville | (Tines 23.7.75 | (Retired April | (1974 ( 11 11 (1 11 11 1J (Also Block 1 i i 1 Re f 1 ( ( ( (( J____________ 1 i | Re f I I I J___ IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION LIVER Angioaarcoaa Cimi ~ (bvlra Ditu 17 August 1981) *VK ifttta of data* DAT - MONTH - YEAR tISA Sheet 2 r*n 20 10 II 12 1) 14 IS COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF RIRTH COtVANY FACTORY FIRST VC EXPOSURE DATE OF DIACN0S1S AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HTGHLICHTS 16 OTHER COMMENTS 09 Ra^wond 08.11*31 FG Cettle- FlngerT Lonlavllla 28.03.43 01.03.74 43 29 1 10 1 1 116.08.13 1 Coodyear (Niagara 12.06.51 1 00.05.68 1 55 11 1 | 1 11 1 i 1 (27.03.09 1 Goodyear 1 INlagara 1 14.10.46 00.03.70 1 1 1 61 11 11 1 12 (Francis A 117.11.18 Flreetone IPottatovnl 13.07.49 02.05.69 1 50 IRachaan 1 1 Pa 1 11 1 1 11 11 1 11 11 _J _J _L 1 1 1 1 1 J J- X 1 1 1 1 1 J__ 13 Richard 01.12.21 HCC Edward Clendenln S Chsrle- 11.12.42 aton 00.03.74 52 14 17 23 20 32 15 899st iyn 24 11.03.73 Taa 2000 ppm RaF 1 haa wrong figure* ra flrat exposure. Louisville Tinaa 29.10.74, 12.3.73. 10.3.76 1 11 11 1 <1 17 110.05.68 | Ta) 1 1 t (Ref 1 1 11 1 1 l 1 1 11 1l 1 1 1 23 |I6.03 .70 | 1 11 Yaa 1 1 l ) 1 l IRef 1 1 1 11 1 19 (02.05 .69 | Yaa 11 1 inigh 10 yralio yra aa (Utility 4 1 |Ref 1 + tetter 1 11 1 11 1 11 1 11 11 1 11 1 11 1 11 l Iraactor op. IServlce op. (of 26 Aprtl 1 Knot cleaner) Dagger (I97R fro* 1 |- eeperate (Oryer op. (Rueeell A Perk 1 |crew cIeaned|Strlpplng op* |to J T Scevell 1 (autoclaves) |3 yre prior (of MCA 1 | leervlce In 1 1 j (tyre plant 1 I 11 1 26 07.04.74 Taa 2000 ppm Charleston Dally Nall 21.7.75 Dubious fabrication caaa Dubloua fabrication caaa IMPERIAL CHEMICAL INDUSTRIES LIMITED FUSTICS DIVISION LIVER Angloeercooa Cum - (Review Detet 17 August 1981) * UK Synten of lt*i DAT - MONTH - TEAR SA Snt I Nt* 21 10 11 12 13 14 IS 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF IIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIACNOSIS AGE AT DIACNOSIS YEARS OF EXPOSURE TO DIACNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS onm COMMENTS USA 11 16 104.11.27 ( RFG |Howard 1 11 11 (1 11 11 _J J 11 17 | Peerenbooa|06.05.31 IFO 11 11 11 11 1 |Loafs(rills 1 1 1 1 1 |LouieIriUs 1 1 1 1 1 | 08.05.50 1 1 1 1 1 1 1 1 | 23.06.55 1 1 1 1 00.00.69 11.10.74 I 1 1 1 1 1 1 1 | 1 1 1 1 1 1 41 43 11 1 19 1 04 127.03.69 Taa 1 11 1 11 1 11 1 11 1 11 11 1 11 11 1 Yes 1 19 1 19 116.10.80 on 11.10.74 1 (1 but no 1 11 post-aortas 1 11 16.10.80 1 11 1 1 (1951-4 VCM Ipolyaer(laatloo 1 1 1 1 1 1 1 1 ( 1 1 (Proa 1954 1 ITable 4 la j (onwards la I Wagoner ti (Arny end other|Teatloony to i; |service. |(1S Senate i| 146-50 Aray (Confirmed la p 1 |H N Johnson i! 1 Her 07.08.78 Il 11l 11 1 I Dr M H Johnoonl 1 Hatter of 1 124.2.El con- 1 Iflmed death 1 |6 years after _J J 11 18 (Charlie (22.04.28 |Arthur 1 FG 1 _l J__ l 11 1 (Aron Lafcel 15.09.54 00.00.75 1 46 21 1 ( 11 11 1 11 11 1 11 11 1 11 11 1 11 11 1 1J __ 1 1 | 11 11 1 19 (Virgil 100.00.15 UCC (8 Charla-| 00.00.43 19.06.75 1 60 | Christian ( 1 atoo 1 1 32 11 11 ( 13 102.11.75 11 11 11 11 11 11 11 11 1 32 (06.06.76 11 11 1 11 1 Yes 113 Fra INevy 1 1 autocleaner1 1 (8 yrn on 1 1 lintel ITyro Btorn 1 Iplaetlctoerl |4 Cnrboeet 1 (operation 1 1 1 1 11 1 11 Yss 12000 ppa 1 1 1 11 1 Idlesnoala 1 ICbaflrned In |H H Johnson lltr 07.08.78 |A]so lolling | Stons Mg. 115.01.76 1 1 1 (WllllnMport |8nn GnMtta 21 Jum 1975 Charleston Dally Hall 21.7.75 I I I I ___________________ I 20 31.08.17 Goodyear Niagara 00.00.55 30.01.76 58 21 18 30.01.76 Taa I HIOSH lattar | of 25.10.79 1 ___________________ I 21 Qiet ter 02.09.09 UCC 8 Charle 00.12.46 Early 77 67 30 22 02.01.77 Taa Hinkle ston 28 yra with UCC at SC Retired I 699SUUO News relesM 23.2.77 IMPERIAL CNEHICAL INDUSTRIES LIMITED rusTica Division LIVER Angloesrcoaa Oiui * (Review Datei 17 August 1981) *0K system of ltl HAT - MOHn - YBAK USA boat 4 rage it 1 11 1 12 131 4 (5 1 6|7 1 1 11 11 1 1 1 8 1 9 1 10 1 11 1 12 1 13 1 U 1 13 1 16 | 1 1| 1 1 ___ L 1J1 J1J 1 1 1 11 1 1 COUNTRY AMO f NAME OR | DATS or I RRFBRRMCB | INITIALS | BIRTH 1 COMPANY | FACTORY 1 FIRST VC | DATS Of tXFOSURB | DIAGNOSIS 1 1 11 11 1 AGE AT | YKARS OF | YEARS OP | DAT! OP I HISTOLOGICAL I ESTIMATED 1 | DIAGNOSIS 1 EXPOSURE TO | EXPOSURE | DEATH | CONFIRMATION | EXPOSURE | OCCUPATION | OTHER CAREER |1 OTHER |1 | COMIENTS | NO l 1 11 1 DIAGNOSIS 1 11 | LEVEL 1 | HIGHLIGHTS 1 1 1 1| 1 1 | 1 11 1J 1 1 1 | USA ( 1 11 1 1 11 11 1 1 1 1I 22 1 102.10.23 1 la this (is this 11.07.47 1 00.01.76 52 1 29 1 28 104.12.76 1 Tea 1 1 1 ILoulavtlle | 1 1 1 Bret 110th 1 1 1 Seans (Louis- i i 1 1 11 1 1 1I t1 11 1 1 ITinea 26.1.76 | laald ha was | 11 11 likely (villa fron AJM jvlctln? i 1 1 11 1 1 11 11 11 1 1 fthe 10th AS | Ivletla nt | 11 11 paper of 1 Pet 1981 1 i i 1 1 11 i 1 11 11 11 1 1 |Ralls Una of | (whoa 8 had | 11 1i 11 1 11 1 Idled by | 11 1i ( 1 11 11 1 126.1.76 1 11 11 1i 1i 1 1 11 1 1 11 11 11 1 1 |8aana to fit | Icaaa described| 11 1i 1 1 11 11 1 |by Dennaber | (1 1i 1 1 11 11 1 (Tamburro 6 Yam| 11 1i 1 1 11 11 1 (In Fab I960 | 11 1i 1 1 11 11 1 | Am J Med idea | 11 1i 1 1 1 11 1 |Vol 70 p280 | 11 Li | 1 11 11 1 i 1 11 11 i 1 I 11 11 1 1 1 23 I 100.00.23 Crest |Fitchburg| 08.09.58 | 06.04.73 SO 1 15 1 14 106.04.73 1 Tea 1 1 1 1 1 11 American INess. 1 1 1 11 11 1 1 1 11 Chemical 1 1 1 1 11 11 1 1 1 11 Coapany 1 1 1 1 11 11 1 1 1 11 1 | 1 11 11 1 1 1 11 24 (Charles 117.05.17 UCC 1 |8 Charla- 1939 ( 27.05.77 1 60 1 38 1 1 247 1 127.05.77 |1Choiangle- 11 1 1 1 IHadlta to (1941-65 non- 11937-59 waa IN N Wheeler | |Edvard 1 I stoa 1 1 ((Niosa I lasrcome |hlgh for laolvaat loff and on llatter ef | Ifoore 1 11 1 Isays 26) 1 |(t Eaalaakl |24 yra (vinyl raala 1 labourer 118.8.77 to 1 11 11 11 11 11 11 1 1 1 1 1 1 26/2779) 1 1 11 1 1 11 1 (unit d 11939-41 nay (J Stafford | (dispersion |have bean 1 elves dataila 1 (vinyl roslnsloxpoeod an (Rosa Kaalnekl | 11 11 1 1 1< 1 (unit flrat Ireactor llatter of | 11 1( t 1 1 1 Isa fitter Icloanar 126/2/79 1 11 11 11 11 1 1 11 1 1 11 1 (helper. tlten|1943 beesas |R Kaalnekl | 1 lahlft (ahlft fitter |(5 Nov 1960) | 11 11 1 1 11 1 (utility nea (1946 bacana |auggaata that | 11 1 1 1 11 11 lahlft utility |N10SH will I 11 111 1 11 11 loan (retain oa 1 11 11 (1 11 11 11 1( 11 1 1 I1 1 1 11 1 1 11 1 11 11 11 1 11 (26.04.65 jregieter elneel (employment waelthla aeoplaan | (terminated (nay be seaocl-| 1 tsted with ASL.I 1 (25) 1 1 1 1 1 1 1 09SMbn 1 1 11 11 11 11 1 1 11 |R N Miamlar | l1 11 1 11 11 1 llatter of | 11 l( (1 11 11 1 1 1 1 11 1 1 120/2/79 and | (Eoaa Kaalnekl | 1 I Removal from register confirmed In R Ksalnskt letter of 5 November 1980 1 1 1 11 1 llettere of | 11 11 1 1 11 11 1 126/2/79 and 1 11 11 1 1 11 1( 1 (5/11/80 ( JJ 1 1 Jl 1 1 1J JJ J 11 IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION LIVER Angioeereona Caaaa - (Review Data' 17 AugtiaC I9S1) *W ijwtw Of dltti DAT - MONTH - TEAR USA Sheet 5 Pag* IS 111 I |2 IJ1 11| 1 11 | COUNTRY AMD 1 HAKE OR | DATE OF 1 1 REFERENCE I INITIALS | SIRTH 1 NO 1 11 tuST 1 1 1| 11 4 COWANT l | 5( 6 1 7 1 1 1 FIRST VC | FACTORY | EXPOSURE DATE OF DIAGNOSIS 15 1 1 26 |John Ierrpl07.07.23 1 RFC 1 11 1 11 1 I1 1 11 1 11 | Inula(villa | 03.10.47 1 00.00.77 | (ap te 2 1 paara 1 after 1 death) 1 11 1 1 11 1 11 1 11 11 1 1 ( 11 1 11 1 11 11 1 1 27 |J L 1 1 lll.0S.16 tJCC IForroat | 1 1 1 1 1 |S Qiarle-I to* | 01.07.41 30.11.76 11 1 11 11 1 11 I1 1 1 11 1 1 1 2R | 1 1 i til.06.17 1 OCC 1 1 IS Oiarle-I too | OO.OS.44 03.11.76 11 1 1 1 29 ( 1 1 1 (12.10.07 ( UCC 1 1 |S Cfcerle-| 00.03.42 tea | 00.03.SO 11 11 1 3o 1NVM |22.riy.22" Tenneco 1 |Fle*ingto* 11.06.64 30.12.80 11 Chemicals | 11 11 1 11 11 1 1 1 1. J1 JL 6 ACE AT DIAGNOSIS 11 9 1 10 1 U 11 11 TEARS OP | TEARS OP | DATE OF EXPOSURE TO | EXPOSURE | DEATH DIAGNOSIS 1 1 (1 11 11 1 12 | 13 I 14 | J1L 11 HISTOLOGICAL | ESTIMATED | 1 | CONFIRMATION | EXPOSURE | OCCUPATION | | LEVEL | | ((1 11 1 13 OTHER CAREER HIGHLIGHTS 1 1 \ i | I 1 t 1 16 OTHER COMMENTS 32 1 (death) 62 61 72 38 1 28 (daatb) 37 34 38 1 16 Ml.02.79 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 1 20 123.11.78 |(RIOSH 1 leapa 27 1 land C 1 ISetlp Halil 129) 1 11 11 11 11 1 33 103.11.78 11 11 11 11 1 16 101.03.80 11 11 11 1 til 1 13 130.12.80 11 I1 11 (1 t1 11 JJ Tea Tea Tea Tie Yaa IbpoMi ia jel| |E Kaataekl I some degrae|ia PVC | |to 22 |plants fro* j Matter of 126/2/79 aod lebealeala (cold roe* to| IProf. Teoburrol Ihut sale laapoaura Ipeete | jracoverp to | Matter of 19/1/79 |ma to VCNJFVC charging| Iprobabip loparator to | 1 1 (high |paata | 1 | Icharglag* 1 | |111 August | 1 1 1 11965. | I |Terminated | 1 1 I loaplopmant | 1 | |Jaa 1966 | 1 J1L 1 I Nigh 11 |Operator to |Expoeura la 1 1 It N Wheeler | 110.10.76 |bmlk and |ltr of 4 Jaa || Jdieperelon PVC|]979 and || (Manufacture ICharlaatoo 11 11 11 1 1 1 IDallp Mall 130.11.78 aod |l Eaalnakl 11 1 126/2/79 11 1 1 11 11 (I 11 1 1 1 1 1 |l Eaalnakl (latter of 16/4/79 11 1 1 11 11 11 11 11 1 1 1 1 1 1 |R Kealaekl ILattera of |19th June 19B0| 16 Sth Nov 19801 |6 - UnknownIMalateaace | 11 1 |9 - Minimal|Mechanic | 1 > 16 pra | 1 | |Elaawhere | 1 1 lit pra | 1 I |Dollar house| 1 I J16 F" lOperator -1 | 1 J ugsnun IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION LIVE! Anglosarcoaa Case* - (levl Datet 17 August 1981) hi< 24 10 12 13 14 13 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF 8IRTO COMPANY PACTORT FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS TEARS OF EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED KXPOSURl LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMIENTS YUGOSLAVIA 01 03.04.14 JlRfl Split 00.00.53 08.04.73 39 20 20 08.04.73 Iti Vinll 8ARIC t al paper Env Health Parapecttwa Vol 17, pp 189-192 1976 02 IS.II.11 Juge Split 00.00.50 12.07.73 42 23 18 12.07.73 Taa* Vinll 03 21.12.31 Jugo Spilt 04.06.54 11.01.76 45 22 22 11.01.76 Taa* Vinll VCM Production VCM Production In hla lattar of 3 Oct 1978, Dr Splrtaa of M10SH changed the atatua of Caat 02 to VCM production auployae. Dr Splrtaa alao notified a new Caaa 03 alao a VCM production worker 04 11.06.30 13.12.38 03.09.78 48 20 18 03.09.7S Taa Eoee Kaalnekl Latter of 19th June I960 2i9suan i( ii j_______________ i 4 TABLE 1 Page 25 Incidence of ASL Cases Per Annum 1955 6 7 8 9 1960 1 2 3 4 5 6 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 Total By date of death 1 0 1 0 0 0 1 1 0 1 0 1 1 5 3 2 3 5 7 6 11 11 9 10 5 6 1 -- Eissnan N.B. 1 Does not Include Italian 01 but does Include German 03. 2 Does not Include Japanese suspect cases. Since post mortem examinations are rare events in Japan, confirmation of ASL is a problem as Indeed is its discovery. 3 The 1977 total Includes US rasp 24 which Is n PhnlanMossrcoms . Distribution of ASL Cases by Country USA Canada W Germany France Sweden Yugoslavia Italy UK Czechoslovakia Norway Belgian Japan Total 27 *** 10 18 ** 13 4 **** 4 ***** 3* 6 2 1 1 2 9l TABLE 2 * Omit ItOl - atypical case of PVC bag extruder. ** Includes GE03 aerosol can filler. *** Includes case US 24 which was diagnosed as Cholanglosarcoma. **** Includes one monomer worker. ***** Includes two monomer workers. i*e. North America Western Europe Rest of World 37 46 8 Total 91 Page 26 Pattern of ASL Casea by Factory TABLE 3 (a) W Europe Of the 46 cases In V Europe, 36 have occurred in clusters at 10 factories* Of the 18 Genian cases, 15 have occurred in clusters at 4 factories* ASL Cases Keoanord, Sundsvall PCUK, Brignoud Dynamlt, Troisdorf RP, St Fons Wacker, Burghausen CWH, Marl ICI, Hillhouse BP, Barry Solvay, Tavaux Lonsa, Waldshut 4 5 7 4 4 2 2 4 2 2 36 Page 27 NB: There are 31 pre 1962 PVC plants in U Europe; 18 of these have had ASL cases (Ref Table 8) (b) N America Of the 37 cases In N America, 33 have occurred at four factories out of a total of 49 factories - in N Aaerlca 41 plants have not had ASL cases* ASL Cases BFG, Shawinigan BFG, Louisville UCC, S Charleston Goodyear, Niagara s^snun 10 11 8 4 NB: There are 29 pre 1962 PVC plants in N Anerica; 8 of these have had ASL cases (Ref Tables 9 & 10) (c) Rest of World The 8 ASL cases are believed to be In 1 cluster of 4 7 clusters of 7 esses . TABLE 4 Page 28 Latency Periods (Tears from first Exposure to Diagnosis) W Europe No of Cases Total Tears Belgium 1 18 France 13 298 Germany 18 326 Italy 3 58 Norway 1 22 Sweden 4 106 N America UK 6 125 46 953 US 27 650 Rest of World Canada 10 204 37 854 Czechoslovakia 2 31 Japan 2 39 Summary Yugoslavia 4 8 85 155 W Europe 46 953 N America 37 854 Rest of World smi7a n 155 1962 Average 18 22.9 * 18.1 * 19.3 22 26.5 20.8 20.7 24.1 * 20.4 * 23.1 15.5 19.5 21.2 19.4 20.7 23.1 19.4 21.7 * Of Che countries with 10 cases, Prance and USA have average latency period above world average and Germany well below TABLE 5 Page 29 Annual Incidence of ASL Cases (Date of Death) by Geographical Area 1955 7 1961 2 4 6 7 6 9 1970 1 2 3 4 5 6 7 8 9 1980 1 Total Western Europe i I 1 1 1 1 1 4 i 3 6 6 6 7 5 3 1 46 * North America 1 1 1 1 1 5 2 1 2 1 4 2 4 3 3 2 3 37 1_ 1 1 I I ( 1 1 1 1 1 Rest of World 1 2 1 1 2 1 8 ______ 1 I I I 1 { < i I i 1 I 1 i 1 1 1 I I < t 1 Annual Total 1 1 1 1 1 1 i 5 3 2 3 5 7 6 n 11 9 10 5 6 1 91 * Includes G03 aerosol can filler but omits It 01 bag extruder *9snun Page 30 TABLE 6 ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING ITOl) KEY EVENTS WESTERN EUROPE NORTH AMERICA REST OF WORLD WL 15678 Viola Maltonl Goodrich 1955 6 7 8 9 1960 1 2 3 4 5 6 7 8 ____ 9 1970 1 ____2 ____ 3 ____ 4 5 6 7 8 9 1980 1 FI G1__________________________ Swi_________________________ G2 NKSv2.UKl.It2__________ G3*_______________________ G4.G5.UK3________________ F2,F3,G6,G7,G8,It3 Bl,F4,F5,F6,F7,Sv3 F8fF9,G10,Gll,G12,Sw4 F10,Fll,G9,G13fG15 G16.G17 F12tF13,UK4,UK5,G18 UK6, UK7,G19 It4 Cl C2 US8 C3 US5 C4,C5fUS4,US7,US10 US12.US16j US11j C6tUS2 | C7j C8.US1.US3 ,US23\ Y1.Y2 C9.US131 Czl US6,US9,US18,US26 f Japl US19 US20tUS22, | Jap2,Y3 C10,US21.US24* | US27 ,US28 | Y4 US17, US29, US30 Total 46 37 8 * Cholangiosarcoma ** Aerosol Can Filler PJST80061400,l-WPX7-2 Page 31 TABLE 7 ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING IT01) KEY 1 EVENTS I 1 WESTERN EUROPE | 1939 40 1 Frll 2 3 4 UK1 5 Sw2 6 Frl,Fr3,Sw4 7 Sw3 8 Fr9 9 Frl2tFr4 50 Fr7,N1 1 Swl,UK5 2 G3** 3 G15,It3 1 4 G7,G8,UK4,G19 5 Gil ,G16,G18 1 6 FR10,G1 7 Fr8,G4,It2,G2 1 8 Fr6,Bl 1 9 Fr2,It4 1 60 I G5,G13 1 1 G9 ,G10,G12,G17 1 2 1 G6 ,UK6 3 Frl3, UK7 \ 41 1 5 Fr5 I 6 UK3 1 71 1 | NORTH AMERICA 1 1 | US24* 1 | C3,US27 | US13, US29 | C2.US19 | Cl,C5.US5,US7-US28 | C4.US3.US9 I C7,C9,US8,US11,US21 | C6 ,US22 ,US26 ( US1 I US12 | US16 | US10 1 US4 I CIO | US18 | US2 ,US17,US20 1 1 I US23 1 t C8 | US6 1 | US30 1 1 \ { { REST OF WORLD 1 1 \ 1 1 J j 1 | 1 1 1 I Y2 i Cz2 1 | Japl.Yl | Y3 1 1 | Czl 1 Jap2tY4 1 1 1 1 1 1 1 I 1 Viola 70 JRL 15679 Maltonl Total 46 37 * Cholangiosarcoma ** Aerosol Can Filler PJST80061400,2 WPX7-2 Page 32 TABLE G WESTERN EUROPE PVC PRODUCERS - START-UP DATES vs ASL CASES (OMITTING G03) | START-UP | COUNTRY NAME | COMPANY NAME | LOCATION 1 ASL CASE ( YEAR OF YEAR J J 1940 (United KingdomllCI ( IHillhouse `I NUMBER (01*04 ( 1st Exposure 144.54 1941 (France 1Rhone-Poulenc (St Fons 103.09.10.11 (46.48.56.41 1944 (West Germany (BASF IWest Germany IWacker (Ludwigshafen (Burghausen 1 (04,07.11.15 1 (57.54.55,53 1945 {Sweden IKemanord 1Sundsvall(Stockvik) 101.02.03.04 (51 .45.47.46 1 Switzerland 1946 1 France ILonza (Lalden (Vise) 1Rhone-Poulenc IRousillon 1 101 ( (46 1947 1 Italy (Montedison (Porto Marghera (02 157 1948 (United Kingdom(BP Chem (Barry 103.05.06.07 166.51.62.63 (West Germany (Huls (Marl 109.10 (61.61 1949 (Belgium ISolvic (Jemeooe (01 (58 1950 1 France (Puk IBrignoud 102.04.05.06.12 159.49.65.58.49 (France 1Rhone-Poulenc (St Auban 107 150 1 Holland (Norway (Shell (Norsk IPernis (Herova 1 (01 150 1951 1952 1953 lltalv (Italy (Austria (Montedison (Montedison IHalvic (Brindisi 1Terni (Hallein 1 1 1 ( ( V? | CO 1 France ISolvic (Tavaux 108.13 157,63 (Italy 1Solvic (Ferrara (03 153 (Spain (Rio Rodano (Hernanl ( (United KingdomIBlP IWest Germany IHoechst 1Aycliffe IGendorf I 118 I 155 1954 (West Germany (Dynamit (Trolsdorf (01,02,08,12,16 ,156,57,54,61,55, 1955 1956 1 I Spain (Spain J1 (Monsanto IberialMonzon (Caiqsa (Sabinanigo 117. 19 ( ( (61. 54 ( I 1958 1960 I IWest Germany 1 Italy (Hispavic ISolvav 1S C Ravenna (Torrelavega (Rheinberg (Ravenna 1 1 104 1 f 159 1962 (Portugal (Cires IWest Germany ILonza (Oporto (Waldshut 1 (06.13 1 (62.60 1965 1966 (France (Italy IWest Germany IWest Germany 1Rhone-Poulenc (Pozzi IWacker (Hoechst (Montlucon I IFerrandina 1 (Cologne I 1 Knapsack(Frankfurt! 105* 1 1 160 1967 1968 1 France (Spain (Greece (Belgium IATO Chimie (Rio Rodano (Esso Pappas IBadiohil IBalan (Miranda de Ebro (Diavata Salonika (Antwerp 1 1 1 I 1 1 1 1969 1970 1971 (United KingdomlVinatex lltalv IRumianca 1 Italy ISIR (United KingdomllCI (Italy IS C Ravenna (Spain (Hispavic (Sweden IKemanord (Stavelev (Cagliari Sardlna (Porto Torres Sar (Runcorn 1Ravenna IMartorell IStenunesund 1 ( 1 1 1 ( 1 1 1 1 ( 1 1 1 1972 1976 1977 (United KingdomIBP Chem (Baglan Bay 1 Finland IPekema (Svartback 1 Holland IDSM IBeek Limburg (France (Soc Art D'vinvl(Mazingarbe 1 Spain 1 Monsanto Iberia I Tarragona 1 ( 1 1 1 1 1 ( 1 1 * Laboratory worker in Research Department pJST80061400,3-WPX7 I TABLE 9 Page 33 USA PVC PRODUCERS - START-UP DATES vs ASL CASES |START-UP| COMPANY NAME (I * A/ * iSItkA/UH ( ASL CASE I YEAR OF | YEAR 1 1939? |*UCC 1 1 S Charleston 1 NUMBER ( 1st EXPOSURE I 107,13,19,21,24,(44, 42, 43, 46, ( 1940? (*BFG 1 ( Louisville (27. 28. 29 (39. 41. 44. 42 1 (01,02,03,04,05,(48,55,45,52,44, | l l (06,09,16,17,22,(62,45,50,55,47, ( 1 1 (26 147 ( 1946? l*UCC { Texas City t 1 1947 i Goodvear 1 Niasara Falls (08.10.11.20 146.51.46.55 ( 1948 1 Firestone ( Pottstovu 112 (49 ( 1 Uniroval ( Painesville ( ( 1950 1 Monsanto t Sorinstfield ( ( 1952 1 Dow 1 Midland ( 1 1 BFG 1 Avon Lake (18 (54 { 1953 1 Diamond 1 Deer Park 1954 1 General Tire ( Ashtabula ( 1 1956 i Air Products 1 Pensacola ( 1 1 Atlantic Refinlns 1 Brooklyn ( 1 1 Borden ( Leominster ( ( 1 Conoco 1 Hebronville ( ( 1 BFG | Great American ( Niasara ( Flitchburg I (23 (58 1 | 1 Plastics I 1 ( I Hooker 1 Hicksville ( 1 1 Pantasote { Passaic 1957 1 Atlantic Tubins ( Tenneco ( Cranston ( Flemlnston HJ t 130 |59 | 1958 1 Kevsor Century ( Sausus. Cal 1 ( 1-- | 1960 i BFG 1 Air Products 1 Borden 1 Watson. Cal 1 Calvert City ( Illiopolis 1 ti 1 cn 1 UCO.' ,1 --* 1 1962 i Tenneco ( Burllnston NJ 1963 t Conoco t Aberdeen. Miss 1965 . { Stauffer 1 Conoco 1 Ethyl ( Lons Beach. Cal 1 Assonet. Mass ( Baton Rouse I ( 1 1 1 { t 1966 l Diamond t Delaware City ( i (General Tlre/Pantasl Mt Pleasant W Va { i I BFG 1 Henry. Ill t 1 1 1 Stauffer ( Delaware City 1 i 1967 t Allied ( Painesville. 0 I ! i 1 Hooker 1968 ( Firestone 1 Burllnston NJ 1 Perrwille 1 ( ( 1 1 1 1969 ( BFG ( Pedrlckton NJ i ( ( Goodyear t Plaouemine i Olln 1 Assonet. Mass f I 1 ( (Formerly Conoco)! ({ i 1971 ( Conoco 1972 1 Nat Starch I Oklahoma City ( Meredosla. Ill I 1 ( 1 1 ! 1 1973 1 Borden 1 Sorlnsfleld 1 1 ( ( Roblntech { Painesville. 0 l l 1 1 (Formerly Allied?)! 1974 1 Atlantic Tubins i Cranston R1 ( 1 ( i ( 1 1 Shintech I Freeport. Tex ( ( 1 1975 1 Certain-teed ( Lake Charles l 1 1 1 Georeia Pacific 1 Plaouemine. La 1 i ( I Tenneco 1 Pasadena. Tex ( ( 1 1979 t Firestone ( Plaouemine _i_____________________ !______________________ 1 * My databank has no information on UCC before 1946 or BF6 before 1950. NB Some of the plants in this list were closed down, some have changed ownership over the years. Page 34 TABLE 10 CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP YEAR 1943 (1941?) 1951 1957 1966 1979 COMPANY NAME i LOCATION 1 | ASL CASE 1 NUMBER | YEAR OF 1 1st EXPOSURE Goodrich 1 1 Shawinigan 1 11 101,02,03,04,05 {44,43,41,45,44, 106,07,08,09,10 147,46,61,46,53 1 \1 Monsanto* 1 1 La Salle 1 1 I 1 1 11 i 11 Goodrich 1 Welland 1 1 1 11 1 \1 Esso 1 Sarnia 1 I 11 i1 Diamond Shamrock Alb | Fort Saskatchewan 1 l 1 1 1J * Terminated 1975 C XI 05 oo ro Page 35 TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES I START-UP| COUNTRY NAME | COMPANY NAME YEAR 1941 1950 1 1Russia (Yugoslavia ( (State Comos (Juno Vinil 1951 (Czechoslovakia!State Comos 1955 (East Germany (State Comps 1956 1957 1 1 Rumania (Poland 1 (State Comos (State Comos (Rumania |State Comps 1 1958 (Rumania ( (State Comps 1959 (Hungary (State Comos 1961 1Rumania (State Comos 1963 (Yugoslavia (Ohls 1965 (Bulgaria (State Comos 1967 (Poland (State Comos 1969 (Russia 1970 (Rumania (State Comos (State Comos (Russia (State Comps 1972 (Yugoslavia (Vinilolastika 1975 (Czechoslovakia!State Comos IRussia (State Comos 1976 (Yugoslavia IHip 1977 (Rumania (State Comos { LOCATION 1 (Vladimir et al (Split (Novakv (Bitterfeldt (Schkooau .(Icechim (Oswelclm (Dworv) (Tlrnaveni (Turda (Rlsnov IBerente Borsod (Borzesti 1Skoole (Varna ITarnow IDIerlinsk (Rimnicu Vilcea (Volgograd (Zadar INeratovlce IKalush Area (Pancevo (Rimnicu Vilcea PJST80061400,6-WPX7 I ASL CASE 1 NUMBER ( 101.02.03,04 101.02 1 ( 1 1 I 1 ( 1 ( 1 1 1 1 1 ! ( ( ( YEAR OF 1 1st Exposure ( (53.50.54.48 (57.51 ( 1 t 1 1 ( is ( 1 VI 1 s ... 1w Page 36 TABLE 12 JAPANESE PVC PRODUCERS ~ START-DP DATES vs ASL CASES 1 START-UP I COMPANY NAME YEAR 1950 1 Chlsso Corp Kanegafuchl Kag I Tekkosha 1951 Mitsui Toatsu 1952 Mitsubishi Mon Sumitomo Kae 1951 Denki Ragaku Nippon Zeon Toa Gosel 1955 Rvo-Nichi 1956 Nippon Zeon Nlsshin Kaeaku 1957 Rureha Kasei Shinetsu Kae 1960 Denki Kagaku Kaneeafuchl Kae 1964 Chlsso Corp 1966 Tokuvama Seksui 1967 San Arrow Kagak Sumitomo Kae 1968 1 Ryo-Nichi Shlnetsu Kae 1970 Chlsso Corp Denki Kagaku Kanegafuchl Kag Kawasaki Yuki Mitsui Toatsu { Nissan Kagaku Shlnetsu Kae 1971 1 Tekkosha 1973 Asahl Glass 1974 Toyo Soda 1975 1977 1 Central Kagaku Toyo Soda Unknown PJST80061400.7-WPX7/2 | LOCATION t I Minamata | Osaka 1 Sakata | Nagoya | Yokkaichi { Kikumoto { Shlbukawa I Kambara 1 Tckushlma I Uozu | Takoaka I Takeo | Nishlki 1 Naoetsu 1 Ohmi 1 Takasaeo 1 Chiba 1 Tokuvama | Tokuyama 1 Chiba | Mizushima 1 Tokuvama I Mizushima | Gol (Chiba) | Kashima | Kawasaki { Sakai 1 Chiba 1 Kashima 1 Yokkaichi t Havatsuki | Sakata 1 Yokkaishl | Kawasaki 1 Yokkaichi 1 Kashima I ASL CASE ( NUMBER 1 YEAR OF | I 1st EXPOSURE 1 11 1 11 1 I| 1 oc-l O | 53, 58 | 11 1 1| 1 11 1 \1 1 1| 1 1| 11 1 1 1| 1 11 1 | \l 1 1 i| 1 1I 1 1| 1 11 1| 1 1c 1 ! 33 11 1 1 0c5n 1 1 3? I 11 1l 11 \! \I 1! 1I 1! I1 1f 1 ___ L Page 37 TABLE 13 SOUTH & CENTRAL AMERICAN PVC PRODUCERS |START-UP| COMPANY NAME YEAR 1953 Monsanto Mexica 1954 Policvd 1955 Geon Do Brazil 1956 Elchlor 1960 Electrochlor Viplastic 1961 Indupa 1965 SOC Faramanga PET Columbiana 1966 Carburo De Col 1967 Plastlcos Omega 1966 Primex 1970 1 Pollcasa Petro Dow 1971 | Polimeros Mex 1975 Rico Chemicals 1976 Petroplas 1977 Indust Reslstoc 1978 1 Huls Brasil i Polychem | Policvd 1979 PET Camacarl { LOCATION | 11 1 Lecherla (Mexico) 1 t Mexico City (Mexico) 1 1 Sao Paulo (Brazil) 1 1 Sao Caetano (Brazil) l (Capltan Bermudez(Argentina)f 1 Mendoz (Argentina) 1 1 Clnco Saltos (Argentina) I | Paramonga (Peru) I 1 Cartagena (Colombia) ! { Medellin (Colombia) 1 i Mexico 1 1 Puebla (Mexico) 1 I Managua (Nicaragua) I 1 Conception (Chile) I t St Martin Puebla (Mexico) 1 ( Guvanllla (Puerto Rico) i 1 EL Tablazo (Venezuela) J ( Tlazcala (Mexico) 1 t Cubato (Brazil) 1 | El Salvador ( t Coatzacoalcos (Mexico) 1 1 Camacarl Bahia (Brazil) 1 ASL CASE NUMBER | YEAR OF l 1st EXPOSURE 1 1 \ f 1 1 i 1 i 1 1 1 1 1 \ 1 1 1 I 1 1 C, 1M cn