Document jJ9wan5yODnodJM1K7yKNyKk

CONFIDENTIAL World Register of Cases of ANGIOSARCOMA OF THE LIVER (ASL) due to VCM REVIEW DATE 1st JANUARY 1990 ********* Collated toy: Or Brian Bennett Occupational Health ICI Chemicals and Polymers Ltd Hillhouse Site PO Box 4 Thornton-Cleveleys (Telephone Blackpool FY5 400 (Telex England (Fax 0253 861632 J 67483ICIPLH6) 0253 86iB6i ) CMA 010700 LIVER ANGIOSARCOMA CASES circulation of register CONFIDENTIAL FE3RUARY 1390 BAGSHAW Dr I M M BAND Dr P R BARRAT Dr G BAXTER Dr P BAYLAC Dr BELLEC Dr BENECH Dr M BENNETT Dr B BERTAZZI Dr P BERTUZZI M BEYNON D W S BISHOP Dr C BORRELLI F E BRAUN Dr C L J BROGDEN M E BROWN Dr M G BYREN Dr David CAMPION Dr Catherine CARTER Dr J T CATANZARITI A CELLA C CHANCE M CLARKE Dr E A CLAYTON H CONTASSOT Dr J C DAVIES J G DELORME Dr F DEPLAN Dr F DIETZ Dr H W DOLL Prof Sir Richard DOMBROWSKI S L S DOORNBOS Dr N DRUMWRIGHT Dr J R DUPONT G EMMINGER H ERNST Dr W EVANS Dr A E J FALK Dr H FARMERY Dr K FAVRE Dr FIELDING Miss C Hydro Polymers Ltd, Newton Aycliffe, UK Cancer Control Agency of British Columbia, Vacouver, Canada AECRP, Commentry, France University of Cambridge UK Atochem, Chauny, France Rhone Poulenc, Aubervillers, France Naphtachimie, Lavera, France ICI Hillhouse, UK Inst of Occupational Health, Milan University, Italy EVC, Brussels, Belgium ICI Runcorn, UK EMAS, Cardiff, UK Georgia Gulf, Delaware City, USA Akzo, Arnhem, The Netherlands ICI Runcorn, UK Shell, An Den Haag, The Netherlands Nobel Industrier, Sundsvall, Sweden Health & Safety Executive, Bootle, UK EMAS, London, UK EVC, Brussels, Belgium EVC, Brussels, Belgium ICI Runcorn, UK Ontario Cancer Foundation, Toronto, Canada Norsk Hydro, Newton Aycliffe, UK Atochem, Saint-Fons, France EVC, Brussels, Belgium Quebec, Canada Atochem, Jarrie, France B F Goodrich, Akron, Ohio, USA Imperial Cancer Research Fund, Oxford University, UK Dow Chemical, Midland, Michigan, USA DSM, Beek, The Netherlands Vista Chemical, Houston, Texas, USA APME, Brussels, Belgium VKE, Frankfurt, Germany Berufsgenossenschaft der Chemischen Industries, Nurnberg, Germany Lever Bros, Warrington, UK Centers for Disease Control, Atlanta, Georgia, USA ICI Hillhouse, UK Atochem, Montluel, France ICI Millbank, London, UK CMA 010701 J FILLINGER J FINCHAM Ms Shirley FOA Prof V FORMAN Dr D FRASE R W FREIESLEBEN Dr W FRIEDEL Dr H P GAFFEY Dr W GIUDICE Dr S GOTTESMAN Dr R T GROISMAN D HILLMAN Dr D W HOWARD Dr J K HOWE Dr W HUMPHRY Dr N F JOHNSON Dr C A JOHNSON Roy N KAIPERT Dr J H KALNAS Dr J KLEIN Dr H LAGAST Dr H LANHAM Dr John LANOUZIERE Dr Claudine LAWRENCE-JONES Sir C LEE Dr F I LEESER Dr Jenny LELBACH Prof Dr WK LEVEQUE Dr G LEVISON Prof Dr D A LEWIS Dr P LIGO Dr R N LO MARTIRE Prof N LUSS R D LUSSATO Dr Josette MALTONI Prof C MATTIUSSI Dr R MELTON B MIDDLETON D MOKKA Mr MONTESANO Dr R MOTTI Dr A A MUNOZ MOUTON Dr M MacSWEEN Prof RNM NAKAMURA Dr S OSMAN Dr J PADDLE Dr G M -2 Solvay, Brussels, Belgium Alberta Cancer Board, Edmonton, Canada Inst Industrial Medicine, Milan, Italy Imperial Cancer Research Fund, Oxford University, UK DiversiTech General, Akron, Ohio, USA ECVM, Brussels, Belgium Berufsgenossenschaft der Chemischen Industries, Heidelberg, Germany Monsanto Co, St Louis, Missouri, USA Montedipe, Venice, Italy The Vinyl Institute, Wayne, NJ, USA Electrochemical Industries, Acre, Israel Diamond Shamrock Corp, Dallas, Texas, USA University of Otago School of Medicine, Wellington, New Zealand ICI Runcorn, UK ICI Australia, Melbourne, Australia Goodyear Tire and Rubber, Akron, Ohio, USA GenCorp, Fairlawn, Ohio, USA Dow Chemical Europe, Horgen, Switzerland Imperial Oil, Sarnia, Ontario, Canada Dynamit Nobel, Troisdorf, Germany Solvay, Brussels, Belgium Dow Chemical, Midland, Michigan, USA Solvay, Tavaux, France Chief Medical Officer, ICI, London, UK Victoria Hospital, Blackpool, Lancs, UK ICI Runcorn, UK University of Bonn, West Germany CDF Chimie, AZF, Bully-les-Mines, France Guy's Hospital, London, UK Chemical Industries Association, London, UK Dupont, Wilmington, Delaware, USA EniChem, Milan, Italy Occidental Chemical, Pottstown, Pennsylvania, USA Atochem, Port de Bouc, France Institute di Oncologia, Bologna, Italy Montedison, Milan, Italy Formosa Plastics, Delaware City, USA Hydro Polymers Ltd, Newton Aycliffe, UK Neste Oy, Espoo, Finland IARC, Lyon, France ICI Duperial, Buenos Aires, Argentina Rio Rodano, Madrid, Spain Western Infirmary, Glasgow, Scotland Japanese PVC Association, Tokyo, Japan Health & Safety Executive, Bootle, UK ICI Central Medical Group, Alderley Park, UK CMA 010702 3 PAQUET Dr Christiane PATERSON Dr J C PIRASTU Dr Roberta POSSBERG Dr J PUECH Dr A M PURDHAM Dr J RAMBAUD Dr J RICHARD Dr A ROBSON Mrs D ROSA Dr HS RUTY Dr J SALG Dr Joyce A SCHIPPER Dr H SCHUCKMANN Dr F SERONNE Dr D SHAH Dr Has SIGRIST Dr J SMITH Prof Allan H SMITH Dr P M SPIRTAS Dr R STAFFORD Dr J STAHNECKER Dr E SULAIMAN Dr TACHECI Dr H TAMBURRO Prof CH TENKHOFF Dr N TEPPER Dr L B TERWIESCH Dr B THERIAULT Dr Gilles THUS - EVENSEN Dr E THOMSON Dr D H TOMATIS Dr L TONER H P VAN DER MERWE Dr H J WALTEMATE H WEJDLING S 0 WILLIAMS Dr DMJ WILSON Prof R YORK J ZOBER Dr M A Atochem, Serquigny, France ICI Runcorn, UK Istituto Superiore di Sanita, Rome, Italy Wacker-Chemie, Munich, Germany Atochem, Brignoud, France University of Toronto, Ontario, Canada RP Recherches, Antony, France Rhone Poulenc, Roussillon, France Saskatchewan Cancer Foundation, Regina, Canada Petroquimica, Salvador, Brazil Atochem, St Auban, France NIOSH, Cincinnati, Ohio, USA University of Manitoba, Winnipeg, Canada Hoechst, Frankfurt, Germany Diamond Shamrock, Dallas, USA CMA, Washington DC, USA Shell Chimie, Berre L'Etang, France University of California, Berkeley, USA Llandough Hospital, Penarth, UK NCI/NIH, Bethesda, Maryland, USA Somerset, UK BASF, Ludwigshafen, Germany Arabian Petrochemical Co, Saudi Arabia Hoechst AG, Frankfurt, Germany _ University of Louisville, Kentucky, USA Huls AG, Marl, Germany Air Products, Allentown, Pennsylvania, USA Huls AG, Marl, Germany McGill University, Montreal, Canada Norsk Hydro, Porsgrunn, Norway Cancer Treatment & Research Foundation, Halifax, NS, Canada IARC, Lyon, France Society of the Plastics Industry, Washington DC, USA AECI, Sasolburg, South Africa BF Goodrich, Cleveland, Ohio, USA Norsk Hydro, Stenungsund, Sweden BP Chemicals International, Barry, UK Harvard University, Cambridge, Massachusetts, USA EVC, Brussels, Belgium BASF, Ludwigshafen, Germany From: Dr B Bennett, Occupational Health, ICI Chemicals & Polymers, Hillhouse Site,PO Box 4, Thornton-Cleveleys, Blackpool, FY5 4QD England CMA 010703 CONFIDENTIAL register of cases of angiosarcoma of the liver due to exposure to vinyl chloride - REVIEW DATE 1 JANUARY 1990 PREFACE : ACKNOWLEDGEMENTS, SIGNIFICANT CHANGES, COMMENTS AND REQUESTS 1 The 14 new cases in this Register are: France 26, 27, 28; Germany 33, 34, 35, 36, 37, 38, 39; Spain 01; UK17, US 42,43. The Spanish case is the first notified from that country. 2 The following 2 cases have been deleted from the Register: Germany 26 (Alcoholic Cirrhosis), US24 (Cholangiosarcoma), 3 There are amendments from the previous Register against cases: France 22, 23, 24; Germany 31, 32; US33, 34. 4 I thank the following for information about new cases: Drs Lagast, Contassot, Friedel, Tenkhoff, Lee, Hamill and Mr Roy N Johnson. For information about other cases I thank Drs Dietz, Fendel, Smith and Williams. 5 So far as I know the following are still alive: France 15 and 28; US33 and 36. I am grateful for information on this subject in the past year, and urgently need to be kept up-to-date, please. 6 In Table 3 I have now treated a 'cluster' as 3 cases instead of 2, due to the passage of time and the increased number of cases in the world. 7 Tables 4E to 4H have been amended, as the number of cases per factory has altered. 8 A new Table 16 has been introduced showing the number of PVC factories in the world so far as known to me. Please keep me informed of any alterations in ownership, openings, re-openings or closures (see Tables 8 to 15). 9 The initials of case UK05 have been amended to RK (not JK). It will be seen that certain cases have no initials against them. Can anyone please help with this? Some of the countries concerned are Belgium, Czechoslovakia, France, Sweden, the US and Yugoslavia. 10 CHOLANGIOSARCOMA As stated above I have deleted US24 which was a Cholangiosarcoma, not an Angiosarcoma. I have heard of another case of Cholangiosarcoma but the significance of these cases is not apparent in connection with VCM. I should be grateful if anyone who knows of any other case where the patient does develop Cholangiosarcoma with VCM exposure, would inform me about it. 11 RESEARCH Please keep me informed of all relevant research and if possible send me copies of Reports. Would recipients of the Register please pass on this request. 12 Please also notify me of all changes relevant to the Register and especially new cases, for which a blank sheet is provided at the back of the Register. FROM: Dr Brian Bennett, Occupational Health, ICI Chemicals and Polymers Limited, Hillhouse Site, PQ Box 4, Thornton-Cleveleys, Blackpool, FY5 4QD, England February 1990 BB/BGS CMA 0 1 0 7 0 4 Ctfrt 0 1 0 7 0 5 INDEX Table Sequence He 1gium Canada Cxechoslovakia France Germany Italy Japan Norway Spain Sweden UK USA Yugoslavia Incidence of Cases per annum (Table 1) Distribution of Cases by Country ('Table 2) Pattern of Cases by Fat: lory (Tab 1 e 1) Latency Periods (Table 4A) Dist ribul ion of Lnlency Periods (Tables 48-411) Annual Geogruph1ca1 incidence (Table 5) LI VFK ANGIOSARCOMA camps (kfvikw date - January tooti) 1 1I Page \ 11 1 1 ASb Cane Numbers by year of Death 1 2-3 1 (Tab 113 b) 1 ASL Case Numbers by year of first exposure 41 (Table V) 1 5-10 111 Western Europe PVC Producers - Start-up Dates vs AS I. Cases (Table 8) 11-18 1 1[ USA PVC Producers - Start-up Dates vs ASb Cases 19-20 1 11 (Table 9) 21 1 Canadian PVC Producers - Start-up Dates vs ASb Cases 11 (Table 10) 22 1 JI bast European PVC Producers - Start-up Dates vs ASb Cases 23 f1 (Table 11) 24 1 Japanese PVC Producers - Start-up Dates vs ASL Cases 25-29 i 1 (Table 12) 1 South & Central American PVC Producers - Start-up Dates 30-38 1 (Table 13) I 39 1 Australasian PVC Producers - Start-up Dates 1 40 1 (Table 14) 1 Middle Eastern PVC Producers - Start-up bates 1 41 1 (Table IS) 1 Number of PVC Factories in the World 1 42 t (Tab 1e )b) 1 1 Blank form for notifying new cases 4i 1 44-50 1 1 I 1 1 6l 1 1 y i M-Vi Sb-5 / `,U 59 60 61 b2 61 64 CMA 0 1 0 7 0 6 OAWFRY AMD REEEItEJKE 1 HU NAME m WJTJiLS date ok bjrih UM 1.1 J SuJvdf Sujvdf i i VM-i Ajhj i 1 I Idle I I.Uiti-ii f l`lt*Ci| I Jeoeppe hkst uc EXPOSURE DATE OK IJIAOHUSIS AGE AT DIAGNOSIS YEA*IS UK EXPOSURE TO DIAGNOSIS YEARS 0* EXPOSURE DATE Of DEATH HJSTOUXJJCAI. | ESTiHATED COME l MAT ION | EXPOSURE | UVEE OCCUPATION --------------- 1------------- Yes J H it^i Autoc leaner I J4 yrs | t*.a | nxpused Lo PnlfworEet | 70U p(a i fi s | (nr 41 hrs | per di| | dfHt | irertainlf | under | !iOU pfa | in b to I I duUcJdves | i%a-i?/2 | exposed l j 'jO-2GU mm \ U hrs pur I day in I ) autocldves | H72-1DV4 | exposed to | S0-2U0 pfm | in auto- I eJdve rucM UTUER CAREER HIGHLIGHTS | | I t/niER COHHKjrrs Dm l ler in j IciurhU y (J yrd) | hepatic tests | iu U t il#V4 |were iHirsd I. ) druer jRetired (IS its) {tub iS/S Uui k in glass fltutiplldl ised i mi. J chmi- |df I'J/fe I(dl imJkLsliv |Ciaplule |ii i mitral and |i-ajuer details | rii e yi ven in a |paper by |llublel el dj J in Aieh. Duly, jlfcd. Six ., | llyy' Hd- |Trav Hud. |U^. j I "J 2 / (wyes I GUI t>22 I I n JO 8J I W | 137V 30 I K" | KCTlRtU J I h'tdi 19/3 j ua.bi>-ui. jAutucJodOei jtirtaun since |lsl sign Julf | bj 01. b/ |S ft s S nths| Hi /I. | 10.11 > jopetdtnr \ j /D; Thordt ii: jpdin UJ./S. | 700 pya | Uh/.b.l | i yttelhs | Ii jllepdl 11 leit S |alleretl UJ. /4 | lM.bl-17. l | bb v 70(1 l I I |Pus it ive Jn iMjyt aptiy 1 P(a I I jil.H Hepa |tet tir 02.DO fi'tiifltht th`I app . | Inloioui iuo (vjkven ui let lei 1/ Nov MtH hm Dr Uc tiL.^i i'cKf*' CANADA Mwel J i m.K Angiosarc fU Cajiei, - (Review Dale: j Jan 1990) dm notms fv.xh All dales use UK sys CMA 0 1 0 7 0 7 1 COUNTRY AND REFERENCE f1 i \ "1 1 T rl ~i------------------ ;-------- 1------------------------------ 2 j1 -i l > 1 6 1 /iS 1 9 | JO | u | 12 | 1 1 1 14 1 is 1 16 L_____________ l___________ _L 4- 4_____________ _J 11 1 11 1 11 11 1i 1 T------------------------------ NAME OR DATE uF | 1 HRST YC DATE OF | AGE AT | YEARS Of | YEARS OF | DATE OF | HISTOLOGICAL | ESTIMATED 1 I | 1/11164 INITIALS bjfitu | COMPANY 1 FACTOR V 1 EXPOSURE 1 DIAGNOSIS J DIAGNOSIS | EXPOSURE TO J EXPOSURE j DEATH | CONFIRMATION | EXPOSURE | OCCUPATION | CAREER I oiwurrs m CANADA 01 1 j 1 t 1 1 l L 1 1 1 IS.12.13 I 1 1 1 SHAUUQGAN 1 1 11 1 4. 4 1 1 \1 1 1944 1 19SS 1 41 | DIAGNOSIS I 11 1 i1 1i 1i 1 1 I1 11 1 1 f i" | 11 l02.09.SS | Yes 1 LEVEL 1 1 _l1 1 i1 i i1 | |Reactor ( 1UGHLI GIFTS 1 1 T------------------------------ 1 (operator 1 (Saoker 1 j 1 02 I l L 1 0b.03.I4 J 11 1 1 i 1J1 1 11 1 | i 1 ii T1 11 t ( 1 1 1 m3 J9S7 1 43 1 14 ] 14 (21.12.S7 | Yes | {cleaner [polynerisat innf 1 l i------------------------------ (Maintenance , jopeiator (Hoiked 1 l l1 I l t I Ii I \miilurjybt, [overtme 1 i 1 03 1 l i J 26.oa.i9 | 1 i 1 1 1941 11 |1 f1 1962 1 42 1 21 f 11 1t 1i 1i | 30 133.03.63 | Yes 1 I 1 | Ipjpefilter J i [Operator, |Sauker 1 T------------------------------ (Worked 1 i 11 1 l I 1 11 l |lore*an Invert ine 1 j 1 04 1 i i 1 OS.04.IS I l i 1 I I94S 11 rl 1 l%7 1 48 | 22 1 11 11 11 11 | 32 (21.01.64 | Yes 1 I 1 | I 1 i [Reactor | Operalor. |Nun-5Btjfcer 1 T------------------------------ J Worked 1 I l1 1 i i t 11 i | e leaner {toman. [overt me 1 t 11 1 I l 1 11 il (water cool Log (Sauker 1 j 1 OS 1 I 1 07.0S.il | J1 11 J11 ( ii 11 11 \1 I1 11 11 1 r 1 1 1944 I960 1 57 | 24 | OS |OS.07.68 I Yes | t J 1 (Reactor Juntl I 11 |Hater cooling |Uurfced 1 l 11 t l i I Il ( (cleaner |uni t [over tine 1 i 1 06 1 I 1 1 IS.12.IS I l1 11 111 1 I1 11 11 1 r 1 1i ti 1i j 1 1 1947 1 1971 1 51 1 24 | 33 110.04./I | Yes | 1 1 (Reactor (Snoker I (Maintenance, (Mbrked * 1 l l1 1 i l 1 11 I |cleaner |ul Iwrighl Invertine 11 i1 l1 1 11 J{ | Sauker 1 \I t1 J1 ii 1 i 11 11 11 1I 11 1 1------------------------------ 07 |Q9.11.19 I 1 1946 1972 | S3 | 26 | 2b (24.12.72 | Yes | |Reactor (Machine shop (Worked 1 I l1 1 I I ) II I ) t leaner (operator and (overt tne 1 1 1 oa l 1 1 1 OS 1 1 1 1 13.OS.20 | IS.07.21 I 1 ( I 1 11 11 1 11 1 jt 1 1 1 1 1 1 i J 1[ 1 11 i 1 1 1 1961 1 1973 1 53 I n | OS |12.06.73 | Yes | J1 11 1 (1 1 11 11 11 1 1 1 11 11 11 J 1 1 t 1946 19/4 1 Si | 28 | 26 {04.09.74 | Yes | I1 1 I i i II t 1 J 1 f Reactor |poly unit Iftnntenance |Snuker 1 1-----------------------------|In plant |cleaner 1 1 |Furnace <p. (turbine shop |2S jrs! Sauker 1 1-----------------------------(Worked |pipefiIter Invert use 1 1 I1 1 i i i |iuinteikince {Sajker 1 1 1| I1 1 11 11 1 Y* F.^jer Oy 3>r DKLuWtt n Anrulcs ii ' Aikjtiaic ikillMjJijgKjue Paris, I 970 Yu 1 23 1to 1 ppiOS l 4 r lams tins case had both a Uepatmu and AM. sinul tanenusly Page CANADA Sheet 2 cuwrnty and REFERENCE NO wue or INITIALS DATE OF BIRTH LIVER Angiosarccaa Cases - (Review Dale: \ Jan 1990) UKY All UK It) FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL (rniEH CAREER HIGHLIGHTS OTHER COMMENTS 10 imL6.Ob.Ib Shawioigan 19S3 61 IJ.lO.2b Gulf Shawinigao 1943 Nov ab 12 BC 14.09.20 Gulf Shawinigan 194b Mar 82 61 13 n 3: > o SoI 00 Niagara | Melland J I1 II It 60 23 U0.U4.77 Yes Reactor cleaner Furnace up. Uintenance, packaging 42 Ob.04.86 High 1943-47 Operator & Supervisor VC Plant Relired 19/2 (Age 4/j Letters Iria Dr Fernand Detorae, Pathologist A M Bibeau, btG 37 27 31.03.82 Yes High I94b-bb (Retired 19/2 |Lelters trum Autoclave [(Age S2) |0r Fernand Operator, | |DeJoiwe, PVC Resins I9bb-6b | 1 | [pathologist A ^ Etibeau, BFG 1 VC | l Neiliia fenufacture | l1 196b-J2 Autoclave | J 1 1l 1 t Operator, | 1 PVC Resins j 1 30 23 26.1.67 l%7-70 High mo-80 Low Poly Cleaner Retired I9UO A Operator (Age S4) Supei-visor Information Ut HU Diet ^, bFG, 1988 Page CZECHOSLOVAKJA l IVKH Anyjnsarc<*d Cases (Review Uale: l Jan 40) coumv AM} REFERENCE HO UK OK INITIALS HATE Or ttlfiTH CLVTAMV I I EACTQfiY I FIRST VC EXPOSURE HATE OK DIAGNOSIS AGE AT DIAGNOSIS YEARS OK EXPOSURE TO DIAGNOSIS YEARS OK EXPOSURE DATE OF DEATH HISTOLOGICAL COHFIRIUTiOK ESTIMATED EXPOSURE LEVEL CZECHOSLO VAKIA 01 2b.0U.28 Kovaky 01.07.S7 24.12.73 4b 24.U./3 Yes Autoclave Cleaner Ob.07.27 lbtfovaky OK II. SO 27.ll.b4 3? 14 26.11.64 Yes Autoclave Cleaner lb OTHER j CAREER | HIGHLIGHTS } UTHEK amEMTS I flARC letter uf giving fiietails fri* |Prut A David |ut Centre Ind |Hygiene and |Occ diseases. I + (jAItC letter ol |l-4-H2 gave |sLeirtkit (altered dates Jlor this case, (j have J accepted t lie (changes sum:* (the dates cemt: |trua Prof |A David of the |Centre of |JndustrlaJ JHygiene and (occupallunal (Diseases. "i Jddles cum? |urigiruj Jy jin- KIOSK. ox > o vl O _l -O FRANCE Sheet t LIVER Angios^cana Cases - (Review Date: L Jan 90) 1 countrf aid REFERENCE HO ji 4 --1 2 56 I 7|a 1 ____________ i_______________ _______________L______________ 9 MIC OH IHITULS DATE OF 1 BIRTH ! coHPurv FACTORY FIRST VC EXPOSURE DATE OF I ME iT DIAGNOSIS ! Duonsis FEARS OF EXPOSURE TO DIAGNOSIS 01 15.04.24 w Rouss illon 00.01.46 16.02.67 43 21 { jo | ii 11 YEARS OF | DATEOF EXPOSURE | DEATH j 1 1 ------------------------- !---------------------------- j------------------------------- | 12 | n 14 | lb j 16 11 i 1--------------------- 1 ------------------------- r-------------------- 1 `--t----------------------------- | HISTOLOGICAL | ESTIMATED I OTHtli I imttH j CONFIRMATION | EXPOSURE | OCCWITIOM j j LEVEL | 1 CAKEH | highlights | OMElfTS j 1__________________ _____ 1________ k 1-------------------------1--------------------------- 1-------------------------------- 19 19.02.67 | Yea | High |lutoclave J |Bei. Bavler at 1 1 [writer and | jal arch. Hal. 1 1 (cleaner | |Ptof. 1 30 o' 1 1 |l9 |rs j |1 Hov 75 1 III p 171-W7 1 111 l I f---------------------- 1-------------------------1-----------------------------1-------------------------------- 02 sn 03.06.11 PCW rtpmud 06.07.59 15.01.75 63 16 12 24.01.76 | Fes | High |2 frs qq {lUliao jftef. ( (ITIOSH no f fauoauer J origin Jg bonne too et | coMBOt) 1 j 1 jlG fra on (polpner- | J |al "Nouvelle (presae | | ] isatjoo | [edicale" | || | jb Hov 19/7 1 II 1 |P 735 1111 f 1 11 1----------------------------- 1------------------------------- 03 HIV 06.01.20 u> St Poos 00.00.46 15.01.75 55 29 29 29.06.75 | Yes J High |Poljworfcer: |tfCH product ion j Ref. Rety et | | 11-0 frs as f 16 yrs. |al Arch. Hal. | | Jauloclave j Italian PUN. |Prof. 1 37 n _____________ 1____________ 1______________ 1 04 WW 127.01.27 1 PCW iBri^uud 19.10.49 16.01.76 t1 I 49 26 11 1 11 1 11 1 11 1 11 1 11L r i 05 29.01.36 KlU [Brignoud 16.01.65 13.05.76 3# 11 11 1 1 1 1 n1 ac 1 >1 1 t 1 1 11 11 o 1 | t 1I 26 04.01.76 | | i Tea 1 1 | 1 -j 1(_______________ 11 fl3.OS.76 1 7es 11 11 II 1 11 II II 11 1 II .11 1 11 1 I1 | (cleaner,, |Shepherd, |6 June 7? | (Cospoundiog |Sawyer, Maaon |p 551 555 1 ll IK 1 1I 11 1I | High jlfcxKjaer | i i----------------------------| J [production J 1 jwrker | [ j 1 |B Ks- 1 1 1 INC 1 | | [nitration [ ( 1 |1B (rs 1 i J1 1 ------------------------- r~ - I i------------------------------ f High FolyvorAer 11 JTboracotouy |Ref. P Coudere 1 11 fra |9th Fefa 1976 |et al "Seaulne 1 II 1 |costal |des hospitaux caaafang! osar j 10 Septeahre j2)Sciotigrq]iby|l976 II |found ASL |Previouslf had II |3)Haeaorrhage (tune 1 |fruu ASL |angi osarcum" II |4)Right |AJsn II Jrtepatcctuuy JpMicbuwski cl II | (al "La Jhaivel k II | |Pre:su Nudicele" | iM\ July 19/'* I ftjge 2465 Page (> FRANCE Sheet 2 LIVEJt Ang i osarcuaa Cases - (Review Date: l Jan 199Q) 3 courntv uo REFERENCE NO MIC OR INITIALS DATE OF BIRTH Fa 14.04.34 0? 26.04.27 08 01.04.34 09 m 08.10.14 ii i------------- 1--------------- 1------------ 1-----------1-----------------1------------- 1-------------- 1-----------------r 4 1i 6 8 5 10 1 U 12 l u 1 14 15 ` | 16 1 1 [ --------------------- 1 1 T1 I FIRST VC DATE OF AGE AT TEARS OF TEARS OF | DATE OF HISTOLOGICAL ESTIMATED | OTHER l --------------------------| OTHER COTAJfY | FACTOR* EXPOSURE DIAGNOSIS 0IAOI0S1S EXPOSURE TO EXPOSURE | DEATH COMF1 RHAT10N EXPOSURE j UCCUP1TUW CAREER | CUMKMTS PC* 1 _j 1 iKriipoud _____________ 1 01.03.S6 12.06.76 42 DIAGNOSIS 18 I J 13 [11.09.76 Yes LEVEL 1 1 T Moderate |(lSSt)-|%0) KlGHLlGIfTS 1 i _f--------------------------- J'JTus aao had I | (NIQSH (2 |rs JAOL prior to I |sajs (nitration (AS. Ana. de l j12.09.76) [itl li frs |Mal. Prof. l 1 [pulyworker jJuly 'll I l (and works |p 64b 6 6. t 1 | lab? [AUL was found I 1 1 (in 19/1 1 ive i 1 1 jyrs before I 1 1 |asl i 1 11 1 1 1 --------------------------- HP Jst iuban 01.07.50 After 45 % 22 (Q2.07.76 Yes High (Plant fore- j 1972-6 atfein |Died of i death 1 (NIQSH do Juan in [sect ion id |seplicae*la i HIOSH I ocnaeal) Ipolyaer- |st Auhao |Saail liver i sajs I |isation jlesioo found i 00.07.76 1j i1 11 Solvay |Tavaua 23.05.57 03.12.75 42 19 19 j30.01.77 Yes Moderate [6 frs packerj (after autopsy _|1---------------------------- |l4ad been i I |& autoclave |tunnel worker i I |clnr Ipreviouslf i I ||4 jrs l I I |autoclave l 1 1 |worker 1 1 11 1 1 i n---------------------------- RP |st Fans 10.01.46 26.04.76 63 2ft 28 [25,12.77 Yes Very j HuJ |K[ jio frs in [Operated 4.76 I i 1948-1966 jisatioo |sulphuric (for reaoval of i I Lesser (operator. [acid factor?. |liK)ur frcai i l Exposure [aulocleaoer (storekeeper A (liver and i I 1966-1976 |autoclave (geoeral (died after o 3 > o M o ''J i i I i i t i i i i I I i i i I i i 1i i laaioteoaoce | services i I i i i i i i ii (second (surgical |operation for |biiio (bronchiaJ |fistula |Paper bf Jl)r fietc et al (in Archives dt: | Ha lades M ____________ i i i i 4______ _____ _____________ 1 i i i I ________ _____________________1 j------------------ ti i i ii j------------------------j____ (Professionals |VuJ 40 Hu 6 j1919 pages |141 1. J------------------------------ Page t FRANCE - Sheet 3 L.lVfeJt Angios&rcru Cases - (Review Gale: 1 Jan 19901 ii _______1 i 1i * J_______ l--------------------------- 1l 1 coumry ud | MIC OR | Dill Of 1 6 REFERENCE | INITIALS | BIRTH COMPANY FACTORY NO 10 1 J_______ \ |vp 1 | 1 j 24. (ft. 19 RP 1 1 St Poos l1 1 ii 6 _____________ J FIRST VC EXPOSURE 00.12.96 i / DATE Of DIAGNOSIS 10.01.76 i 61 AGE AT | DIAGNOSIS | j 66 1 i 9 YEARS OF EXPOSURE TO DIAGNOSIS i---------- 1---------------- 1-------------r 10 1 11 12 13 l U 1 16 J t --11--------------------------- 1 YEARS Of | DATE OP HISTOLOGICAL ESTIMATED | | OTHER Lb ( OTHER EXPOSURE | DEATH l CONFIRMATION EXPOSURE | OCCUPATION | emu CUMENTS 1 1 1 21 |10.01.76 Yes LEVEL High 1 | HIGHLIGHTS _lJ---------------------- 1 |Autoclave |10 yrs id Died ot il {cleaner {ecbamcal pu Lnun&rf ll lI Il 4_______ 1 i____________ 1 11 \l 115-.02.12 RP 1 1 1 1 SI Fan* 00.01.41 12.06.76 66 1 J7 il il 1 | 1 31 |l3.11.76 Yes High i i 1 1 1 {1941-1946 {engineering 1 La 6 {iixhrst rj days after j 1946 196b surgery 1 1--------------------------- 1 1i l Il |po!jer- I 1i l Il JisaMon I 1i l Il [general l o 1i 1I > lI lI l l 1 l ll lI ll II |purpose {worker. jim-Hf2 jvai I i I I 1I I Il [synthesis I 1I l ll |(HC1 A I 1I l lI [Acetylene) i 1I 1 II fForeaan l 1i I II l(*9tt>t I 1i 1I l l ll lI |de Milrise) i 11972 1 11 12 1 1 [16.06.14 PCI* Hrignoud 09.02.49 00.06.79 11 30 85 1 1 123.06.79 Yes |retired High [dontaer i i1 1l 1 II [production i 1I 1 ll |and polyaer-1 laation operator 010712 n 40I9.0t.il Solvay 23.09.63 26.06.79 16 l I I I I I I t I i |AutocJeaoer |2 yrs a9 cycle|Ciyaret te |2 frs. {ectwaic. faoker until |Auto- |lt> yrs as |i9J4. ill <ai {operator |enaaeller io |uf 19/7 due 111 |9 irs. |sanitary ware |Oesophageal [Cupolyners |anut act ore |varices. |4 jrs 1 1 1 1 I i i i I |Surgical | intervention |2i.lB./9 | (right | hepatectcay) 14 06-04*24 ChJoe 1st Pons m3 0G.07.81 6? 36 29.BJ.8L Ves (ferj High [l`MJ 19/5 |l9/5 -19/9 I j Ctuw* t I I II | I (l-n^rly | I I I| i 1943*19/6 j A 3 J t ppea <>t juiiiteoauce arid | juhs ijh fwuik I I I t WIJ I I I I I i Intern 11 - JumifatJ me | I II III II I enttf j lh suin'enance I II II III III II II I I 19/6-19/9 |m van l.:\i | jl'liMVSS | I I i___________1_______ _______ 1------------------ 1---------------------1--------------------- 1--------------------L J--------------------------- 1______________ 1_______________ I__________________ L Page 8 FRANCE Sheet 4 LIVER Angiosarcona Cases - (Review tale: l Jan 1990) I country um REFERENCE NO JUIK OR INITIJU-S DATE OF birth CUNPUY 15 OEP 03.01.3? Chloe Chime (fomerlj RP) St Pons FIRST VC j DATE OF EIPOSWRE j DIAGNOSIS AGE AT DIAGNOSIS YEARS OF YEARS OF EXPOSURE TO EXPOSURE DIAGNOSIS DATE OF DEATH HISTOLOGICAL CONFIRMTION ESTIMATED EXPOSURE LEVEL OCCUPATION 07.07.55 28.09.62 45 27 27 Alive Yes High-20 yr Autoclave Moderate cleaner 7 yrs 1955-1962 autoclave operator 1962-1982 OTHER CAREER HIGHLIGHTS OTHER COMMENTS Left Hepatectueq L983. J C Cantaaaol Letters of 5 10 83 and 29 7 86. 16 GDI 13.07.22 Chiue Chlaie (Formerly RP) St fans 17.10.41 05.01.63 61 41 03.04.63 Yes High-33 yrs|Polfnerisat-| Moderate- f ioo Process | Low - 5 yrs | Mao | It j Maintenance f |Worker i 1 [Health & | l 1 | |Safety Agent| [Retired |jan 1979. |j C Contassot [Letters of |5 10 1963 and |25 7 84. I 1 l t 17 22.02.23 Chloe iSt Fans 17.06.46 03.04.63 60 34 28 03.04.63 Yes High - Autoclave Other sectors Retired ChtaJe 23 yrs Cleaner of St Fons 01.01.79 (Fonerly 1046-1971 Factory 1971- J C Contassot RP) 1976 Letter of 5 10 1963 18 14.07.42 Solvaf Tavaux 09.09.63 21.03.84 42 21 27.12.64 21.03.64 High-12 yrs Autoclave Low - 9 jrs Cleaner o 3: o ui 09.03.84 Right Mepatectunj 05.05.8424.09.84 cheaulberapy for lungelastasis : partial rued sstoa. Utt.84 - Live* recurrence. JO.84 - Lung: evolut iutj of (be disease PtMje y frarce Sheet S LIVER Angiosarccaa Cases - (Review Date: 1 Jan 1990} 10 12 13 16 COWIRY AID REFERENCE MO INITIALS DATE OF BOTH FACTORY FUST VC EXPOSURE DATE OF OIAOQSIS AGE AT ouausis TEARS OF EXPOSURE TO duqiosis YEARS OF exposure OATE OF DEATH HISTOLOGICAL COMFlRfanOM raacE 19 MZ lb.12.32 Alocbea Brl(ptoud 07.04.S9 26.10.04 52 25 06.11.65 LEVa High Autoclave operator a cleaner OTHER CAREER \ OTHER | aworrs HIGHLIGHTS I H--------------------- [Hfocardl&i (infarction j i960. Coronary |bfpass 1961. |Letter frun Or Cootassot 5.4.86 Portal Brifpioud Yes20 02.03.23 Hocboa 19S1 27.12.65 63 34 22 26.12.65 High Autoclave [q other parts fibrosis fra Joperator and of factory 26.04./4. The Icleaner since 1946 illness was dia^msed as Ipreaaablf |work related Jen 20.04. /4. (Letter froa | Or Con tasset J05.04.66 21 01.10.40 SEP 1959 03.06.86 Hootluooo 27 22 13.08.2B Atocbea 01.09.56 05.11.67 59 29 26.06.86 Yes 06.09.68 II High Autocleaner Aainleoance 4 fears worker l Hepatic lest Hdf 64 noraa!. | Hepat ic test Jttaj 66 showed |abouraaJities. | Let ter fna Jf)r fiarrat ]18.07.86. High 1958-70 Low 19/0 64 12 years (Autoclave | worker. | 1I (14 years in J (Control Koua Letters trua | Ur Cunt assett, | Atocbea jj.12.87, |29 / 66, J24.0I.89 23 i CMA 010714 U7.02.27 Atocbea II II l I I St Foos ll lI lI II lj 1944 1966 63 J____ L J1.IH.B9 II II II II J____I___ L High Autoclave (cleaner A [dll PUC |pf\MJuct ion | jobs Partial |Hepatectuaf, Jtpc J68, Cheaulhei apy |Inforaatton fiua (Ur J C Cuntossol, Alutfwa, 1966/69 Page 10 France Sheet 6 LIVER Angiosarcoma Cases - (Review Date: 1 January 1990) ---------------- 11-------------------1 23 < is _______________i____________ 6 7 8 9 10 11 12 13 14 15 cowmtY jud REFERENCE NO HUE 08 INITIALS DATE OF BLRTH cueamy F8CTGH FIRST VC grnngiafr YEARS OF DATE OF AGE AT EIPQGWE YEARS OF DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF DEATH HISTOLOGICAL ESTIMATED OJNFIRfUTION EXPOSURE OCCUPATION LEVEL OTHER CAREER HIGHLIGHTS lb OTHER OMENTS 24 HA 08.12.26 Atochem Brl^oud 1943 1988 62 46 35 01.12.88 Yea High PVC Product .on Liver transplant Haf 1968. - 2 fears Information from Dr J C Cuatassot, NCV Detect! on Itocbea, 1988/89 - 3 fears 1 PVC Product ion maintenance - 30 fears 25 B6 02.03.30 Solver Tavaux 1962 1966 58 26 21 07.05.08 Yea 11 fears) Pol fcleaner High) - 5 fears Polffloor ' - 6 fears 12 fears Control Root Low i - 12 fears Prinarf Liver Timour Helastases lung,, brain, bone, spleen, kidney. Information frcm Dr H Lagast, Solvaf, Hoveaber 1988 26 HG 29.11.40 Solver Tavaux 16.04.63 25.10.88 48 25 15 012.11.88 Yea High Autoclave 12 fears Cleaner Low for 15 3 fears fears Died bf batmorragic rupture of the timour. No surgery. Letter from Dr H Lagast, Solvaf, 28.4.69. 27 8C 1929 Atochem St Fans 1954 1988 59 34 30 00.01.89 Yea 1954-74 Autoclave High Cleaner and 1974-84 all PVC Low production Jobs Notified bf Dr Cootasset, Alocbem, December 1989 28 JG 1926 Atochem St Funs 1942 1989 63 C t > o H o Nl ___ ______ cn ____________ 47 20 Alive Yes 20 fears 10 fears High monomer analfs is (labs) 10 fears production PVC Notified bf Dr Contassot, itoebem, December 1989 1 Pe^e 7 GERMMY Sheet 1 LIVER Rngiusarcaaa Cases - (Review bate: 1 Jao -------------------- 1 ---------------------- 1----------------- 1--------------------- 1------------------------ -------------------- 1 -- 2 3 4 l5|6 | 7 a 9 ______________ i___________ 1______________1________________ LO OXJVTBV UD RETEBOll no UK ON INITIALS DATE Or BOTH COWANT factont FIRST VC amswE LUTE 0f DIAGNOSIS AGE IT DIAGNOSIS TEARS OF EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE GEBMUTC 11 DATE OF DEATH it i-----------------------------1------------------------------ 12 | 13 | 14 l 15 | lb tItill HISTOLOGICAL | ESTIMATED | | CQVlUliTIQM | EXPOSURE | OCCUPATION j OTOE* OfliEElt 1t | UTIIUL j 0CVWNTS | LEVEL | | HIGHLIGHTS j 111 1 01 00.00.30 4 4 - 01.10.56 19.09.60 3a 12 12 25.01.69 Tea (K10SH) Pnifimriber 02 00.00.31 4 4 14. 10.57 25.09.70 39 13 11 14.12.71 Tea INIOSH) Polyworker 03 00.00.30 12 12 09.06.S2 00.03.73 04 00.00.30 8 A 16.04.57 26.11.74 o X > o H o Si H* ------- ____________ _______________ O' 43 21 16 10.10.73 Tea (NIOSH) Filling Reported wider pesticide Dun polfaer- aerosol cans isat loo with VC workers in NIOSH list of 31.3.77. Ttiis of course Is slricllf correct. However 1 wueder I whether this 44 17 i an had high i exposure to i VCH in his i xo filling i<jperatioa? ________________ t- ii i 200-500 ((iPolieorter ijl958 ms |cllnicel 17 25.11.74 Tea (NIOSH) but high Jleapororr |autuclener |detalla in during l |r|eutocleaner |ior I jr |pnper bJ eutocleenerj 1 I01**1 et al I| jVirdma ir<i || Jl Path H/b ij |J12 p 175-203 11 11 ! * ________ -- _________________ i i1 ii II------------------------- !-------------------------- f Page 1 J- GERHUfY LIVER Angiosarcoma Cases - (Aeview Date: l Jan 1990) Sheet 2 -------------------------- ! l-------------------- 11-------------------11---------------------- 11-------------------1 -------------------- 1---------------------- -----------------------1--------------------------- 2 3 4 5 617 8| 9 I| 1| coumnr aw KEFQUMCC no KANE Oft INITIALS DATE OP BOTH ouran factory FIRST VC exposure DATE OF outansis AGE AT | YEARS OF DIAGNOSIS j EXPOSURE TO j DIAGNOSIS _____________ _______________ 1 1 1 i GERMANY 11 10 TEARS OF EXPOSURE i----------------------------- 1-----------------------1-------------------------1---------------------------- 1------------------------------- 11 1 12 | 13 | 14 | ' 15 | lb 11 lI)I<I OWE OF IHIST0U1GICEL I CSTDUTED | | OTHER <1 I OTHER deith |aarmnn | exposure j occupitic* | cekecr j canons | 1 LEVEL I I. HIGHLIGHTS j 1 ill I 1 Ilf 1 1 III |Cml Lrad 11 1 11 1 1 05 00.00.36 11 11 D2.O4.60 1 10.12.73 36 | 13 05 lb. 12.74 |Yea (BIOSH) | |BG Chemie J |Reported under 11 j l |is | {non-polymer- (M10SH gives 11 I | |"dieufitr| | jisalioo as Case Ob) I1 I | |laboratorian| | workers in 11 11 | | [in the | |H10SH list of j | (Techno- | |il.3.77 and 11 | | | logical | 11.70. djn*t 11 I | (Research | {think, this is 11 I | |Department* | ja correct 11 | | |(KIOSH says | [classification 11 L | {assistant { |by KIOSH. The 11 J | | factory j |aao nay have 1 j | [chemist j {been involved 11 | | (which any be| (in VOl 11 | | j wrong j |pu)paerisalioa 11 | | |translation)! |in pilot plant 11 t || | |or in auo 11 | lit (plant. 11 11 1 111 l 1 III | 06 00.00.52 7 7 16.12.62 1 00.00.76 43 | 13 12 09.01.75 | Yes | |PVC - Hanu | | 11 | j jfacture | j (N10SH gives 11 | | Isfalft Leader] j U Case 05) 07 00.00.2b s 1 I 1 a 15.04.64 | 12.11.75 1 1 1 49 | 21 1 11 1 1 III 1 III 21 13.11.75) Yea | |PVC Haiu- | 1 1 | j 1 1 (hosh | | llacture and | j 1 1 h;i 12) 1 1 1*11 wrt J j 11 11 | | |lncl auto- | | j j |cleaning | | 11 1 1 112 Y 1 | 11 | | |(I954-fa6* | | ' 11 | | )Funaan Ted>| ] 11 1 1 lit* l|ra j j n 31 oa ^ _______________ I1 1 (oo.oo.H 4 4 1| r1 1 1 1 1 I 1 19.07.54 | 06.04.75 | 58 | 20 | | 20 25.12.75 ] Yes | |( 1967-1976* | III III | ? |Pulfwrker | ? | 1 | | 0! * 01 1 1 1 SI --1-------------------- _______________1____________ III III III 1 1 i1 1 1 1 t III 1 1 1 III 1 ------------------ L---------------------------1111 Si Page GCUUin Sheet 3 LIVER Angiosarcuaa Cases - (Review Dale: l Jan 199U) -------------------------- 1I-------------------- 1 -------------------1----------------------- 1 2 J| 4 1 i 16 1----------------------- 1---------------------- 1 /a county u REFERENCE WUC OR INITIALS | \ DATE OF | BIRIN j coffin ____________ |______________ 1 | FIRST VC FACTORY j UNSURE DATE OF ouoaosis AGE AT DIAGNOSIS NO 1 1 11 ____________ 1______________ 9 VEJUtS OF EXPOSURE TO DIAGNOSIS GEMMW 09 00.00.J4 2 2 20.02.81 16.06.76 41 1 10 | 11 1----------------------------- 1-----------------------1-------------------------1----------------------------- 1-----------------------------| 12 | 13 | 14 | 1 IS | 16 I1 I1 11 11 11 |1------------------------------ VEARS OF 1 DATE OF | HISTOLOGICAL 1 ESTIMATED 1 | EXPOSURE | DEATH j CURF1RMTIQM j EXPOSURE j OCCUPATIO* j OTHER CAREER | OTHER j OMWEXTS I| j LEVEL | j HIGHLIGHTS I1 I1 II 11 11 11-----------------------------11------------------------------ III 1 II III 1 13 ( 24.03.70 | 11 Yes (High peaks |l2 jrs pol|| 1 (worker incl 1 110/78 ICoolimed t| | 1171 auto- | leverage || | |clave | (exposure first 1| |( jj | {cleaning | ( |Control rwaj 1 |l fr I |9 jrs 150 turn, |occ 1000 pgm. (Next 3 |rs av. 10 (NIOSH gives as Case 11) u (MIOSH gives as Cass 10) 12 o 3: > c V* c> 4"a, ta 5 00.00.36 2 00.00.29 a 00.00.3B 4 2 01.01.61 00.01.77 40 8 10.10.55 28.06.77 47 It lit |75 ppa. Last. 11 t1 1 |jr av 35 pps 11i________________________________________________ 1 ____ J I 1 1 1----------------------------- 1 1 1----------------------------- 1------------------------------ IB | 10 f07.03.77 | Yea |0igb peaks 110 yrs polf-| {Average III | || | |workerincl J | 1171 auto- | (exposure first |9 frs 150 ppa, III | {clave | |occ 1000 ppe. Ill III | |cleaning | 11 1 (Last jr av hwi. CHH III II 1 (letter of III II I jj| ill 11' III 21 | 22 |2B.06.7? | lea { High |j frs auto- | III 1 jclave | (21.114.78 1 1 | | III 1 j cleaner j j III 1 |19 ,rs | III III 1 [filter j 1 [operator j 4 00.00.61 00.10.77 39 111 ill || II 1 1 16 I 6 | 07.10.77 [ Tea 1 ? |fVC Raeu- | 111 1 |lecture j 111 j jj | |Autoclave | j [worker lor | III III i |6 Its | III III III III til III III ,111 II 1 III III III III _______________ III III ------------------ 1-------------- 1------------ 1i111 | | j 1 1 j j | j | 1 1 1 1 1 1 1 1 Page 1 >1 GERHAIIV Sheet 4 ---- I 1 21 cowry aw REFERENCE HO HUE OH INITIALS DATE OF BIRTH 13 oo.aa.i4 (14) _________ ________ joa.oa.29 15 1 {H10SH gives 1 Uus as 1 Case 11) 1 1 1 I C 1________ 1 4 CGMPiHT 7 s LIVER Angmsarccna Cases - (Review bate: I Jan 19%} 'r 1---------------------1 56 1 FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS 7 00.00.60 | 06.04.78 a AGE AT DIAGNOSIS 63 -- ---------------------1------------------- 1-----------------------------1---------------------- 1------------------------- 1---------------------------- 1------------------------------ 9 10 | II | 12 | 11 | 14 | IS | 16 YEARS OF EXPOSURE TO DIAGNOSIS II I1 11 1 III VERAS OF | DATE OF | HISTOLOGICAL | ESTIMATED | | EXPOSURE j DUTH | COMF1 RMTIQHj EXPOSURE j OCCUPATION j OTHER CAREER 1 | | OTHER j COWIEHTS jj j LEVEL j j HIGHLIGHTS j II I1 |1 11 18 14 119.05.76 | Yes | | r1------------------ 11-------------------- | |p U Best 1 II Ij | jletter of 1 II || | jiOtb June I960 1 II || | [enclosing data 1 II III |fr 1 || | | | |Hr H P Fnedel 1 II j | | jo( BG Chenie 1 1 I1 I1 11 1I 11 11 1 | |Hot an | | | |F W best 1 | |Anglosarcau | | | [letter of 1 | | In Ids letter | | j [loth June I960 1 [ |of 21 12 81, | | | [encfusing data l 1 |Hr Frfedel | j j jfrun 1 | jsaid this was [ | | |h P Friedel of 1 | |a "Piatlenepl-| j | [BG Cbeatie 1 | j thelAarzlnon | | | [withdrawing 1 | |0er J | [ |thls case 1 j Ispeiserohre" | | [ | 1 j j(a carciaona III | 1 j |of the j | j j 1 | |oesophagus) III [ 1 | |not attribut- III | 1 j jable to VCM 6 j | j j 1 | [not reraiyitand| | | | 1 j |as an Indust- Ill j 1 | |rfal disease III 1 1 1 11 1----------------------- 1 j--------------------------1 B 19.10.S3 | 09.10.76 49 25 25 (23.10.78 | Yea | ? |Autoclave | |loguiaarouu I || | (cleaner and | f confines! 1 j| | [worker. | |09/79. Se 1 || J |Drier | |detail of this 1 || ( (operator. j J& also cases 1 jj | |Later shift j (9, 11, 15, lb 1 1 II_________ 1 || jj 1i | (leader jj i [ j i |& 1> given in HRU Report tor i h_ _ _ _ _ _ _ _ _ _ _ _ _________ O t-* o vl >o r |1 GEHNANV SI**;t S courrev ME) REFERENCE NO NAME OR INITIALS DATE OF' BIRTH 17 (HIOSH gives as Case IS} o 3: o si W O LIVER Anghosarcxa i Cd^es - (heviiir bate: l Jan l***)) -------------------- 1---- IS FIRST VC EXPOSURE DATE OK DIAGNOSIS AGE AT DIAGNOSIS VEARS OF EXPOSURE TO DIAGNOSIS VEARS OF EXPOSURE DATE OK DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION other ( CAREEN | HIGHLIGHTS | criuEH CUMEMTS 10.01.bb 07.08.76 (Lelbach suspected ASL at Feb L97S laparotcay) 23 yes 1 ASL and | Hepatocel Lular| Carciuaa | 1 1 1 1 1 1 1 1 1 1 1 High jAuluclave ( |worker till | |l4t4. | {Leader and | (aster ( 11 11 11 11 11 11 l1 11 ll l1 1 | Aimj 1 osar<xaa |conl irod. itull details jol illness |since March 14/J given 10 |NRU Med Insp |ttep lor 14/tt. (Different |delaiJs given in "VC (Associated |Disease" by |Leibach acid |forstel ler j 41*361) p/1. 01.11.61 14.06.76 I 2b. 12.74 T 66 00.00.'jb j 11 1 j------------------- _u_----------------- 1-- M 24 jf High Autoclave worker Ves Nelastasing ASL Autoclave 4ui her High Autoclave Ankct J Aug losarcuK (conlinwd. (Annual report (of Hie North | Rhine |WestphdJla (Medical | Inspectorate |ji 147H |pages 14/177 |gives full |JetaJIs. Vinyl |chlunde (disease | diagnosed |U2-U2-/3. | Oesophageal |vac ices. |RadiuJogicall| |confirsed aero |osteoijsts. I G------------ |0r Besche | let let of )| I 04-62 to |h. U n I Ad _t________- J'rjtjc' I GERMANY LIVER Angiosarcima Cases ( Review bate: l Jan 1990) Sheet 6 11 1 |2 | ------------------- 11---------------111 11 l 1 |4 1 1 -- ---------------- 1---------------- 1------------------- 1--------------- i------------- (---------------- 1------------------1------------------- n------------------------------------- 56 J|a| 9 10 11 1 12 t 11 I 14 I 15 I It |1 I1 till 11 1 1 I 1------------------------------------- 11 1 H1ST0 III | COUMRY UK) 1 NAME OR | DATE OF | REFERENCE jINITIALS | BIRTH jaflPANY FACTORY NO j || FIRST VC EXPOSURE DATE OF | AGE AT | YEARS Of DIAGNOSIS j DIAGNOSES | EXPOSURE TO j j DIAGNOSIS YEARS OF EXPOSURE MK OF | LOGICkL | ESTUUTEU | | COWL* BUTH 1 CONFIRM- j EXPOSURE j OCCUPATION j CAREER j mo* j LEVEL j j HIGHI.IGtrrs | j | OTHERCUNHEOTS J1 |1 1...............1.............................. -- J 1J1 111______________ 11 1 11 |-------------------------------------- 20 | joo.oo.is | 4 4 14.02.61 00.04.00 65 19 n 19.10.80 Yes | High |Autoclave | |Dr Besche Letter of i ii HaeaaogioJ |Uurker | |]i-Q4-B2 to i it Endutheliana | | |[)r g ii F Adats i ii of liver with | || i ii Netastases J J| i* ii 21 | 00.00.11 4 4 01.01.62 00.09.79 66 ia L n 19.06.80 Yes | 1 1J 1------------------1--------------------- -- High Autoclave | Dr Besche letter uJ 1 pronounced Haeaangio| Worker and | H-W B2 to 1 clinical Endolhelicaa worked in | Dr U G F Adans 1 liver of Elver with jdrfiag shop | 1 s|ptas) 1 Netastases l 1 _____ 1 1 22 00.00.2] 4 4 I5.10.bl 28.oa.ao 59 19 11 06.12.81 Yes High Autoclave Chargehand, Dr Besche Letter of Netastasi ag Uurker subsequently LJ-M-02 to ASL Foreman Dr W G f Addas 2i 24 25 06) If 00.00.27 a b 1955 26.03.79 52 24 21 29.09.01 Yes High Cheustr; Prinarf hepatoceJIar (>J00 pp.) Worker care iikana; proliferation ol the sinusiodaJ ceLJs with i sinusoidal ectasia. i 'riedel tetler 21-12.B6. ii i 1 1------------------- ----------------- E---------------------------- | |u0.00.28 a|a 1969 11.10.32 54 1 n 1 12 28.05.Bi Yes High Autoclave j |Prof Eder (Munich) I1 1 11 <>J0Q ) Cleaner | |letter 22.ua.Bi, 11 11 11 j 11 | toei.oo.2j j b | 1 III a I960 1 ________ J 1 28.U9.ai 58 | 21 1 1 1 11 i 14.0I.8J | 1 Ves High | (Fried*) letter 19.04.85. ----------------- 11j------------------------------------ Polrclave | Uurker and | |Prof Selaair (tfcinu*) jlelter 22.U8.8J. t III 1 1 kuluclave | (friedel letter 14.04.B5 1 1t 1 1 Cleaner j 1 i________________ 4------------------------------------------------- - ,, ---------1------------------ 1-------------- 1---------------1--------------------- -----------------------1-----------------------1--------------------------- -------------------- 1-------------------1------------------- 1---------------------- 1------------------------1 21 III 11 (Deleted on advice of Dr Tenfchotf December 1989; 1 >1 j III 111 2 |0U.U0.2B 1 4 | 4 j 1955 o1 M1 III ill 11 11 ---------------- 1-----------------1------------------- ia.0l.8J 1 55 1 28 11 11 1l |Alcoholic Cirrhosis, not VCH associated. till 1j 1 ----------------------- t--------------------------------------------------- 18 IU2.0J.B4 | yes | High kuluclaae j |1 1 |rledlKrt,ll| ||| |W2 I |Lel6acll. |r..lel lelte. JI9.U4.a5 Page GERMANY LIVER Angiosarcoma Cases ( Rev ten Dale: 3 Jan 1990) Sheet 7 -- 1 2 14 I b 6 1-- ----------------------- 1 ---------------------------1 76 9 10 ------------------- 1 ----------------------- , n 12 n t 11 | t 16 | lb ------------------------- 1__________________ L__________________________________ 11 HISTO 11 coumy and REFERENCE . MO 28 Hue oft INITIALS DATE OF FIRST VC BIRTH cavun wen** EXPOSURE 23.il.23 7 7 01.10.60 DATE OF DIAGNOSIS 11.OB.86 AGE AT DIAGNOSIS 61 VEARS OF EXPOSURE TO DIAGNOSIS 25 YEARS OF EXPOSURE DATE OF DEATH 25 25. OB. 86 LOGICAL CONFIRM ATION es ESTIMATED | OTHER I EXPOSURE OCCUPATION | CAREER | OTHERCIJMENTS LEVEL High | HIGHLIGHTS | ________________ |___________________ l__________________________________ 1r Process j |Annual VCH screening worker J j24.04.86: no ctmplaint, 1974-84 | |no abnormal it I detected. | 11470 two-thirds 01.10.60 - 33.03.84 PVC | J j (gastrectomy for ulcers. ||971 Coronary throatusis 11983 Femoral production, | |i^>lanlalion agitator | |l984 Pulmonary embolism area | jand pleurupnetaortia. | J landers letters 18.09.85 j [and 04.02.87. ________________ 1__________________ 1------------------------------------------------------ 29 00,00.22 2 2 3962 36.02.83 63 21 19 35.02.84 Yes High Chemistry J Haemang uisarkama. worker |Friedel letter 23.12.86. ___________________1----------------------------------------------------1 30 00.00.17 4 1 1951 07.01.80 62 29 25 25.05.83 Yes High Polyworker | Haemang iosarktaa. Shift leader (Priedel letter 23.12.86. I 1 33 00.00.23 8 8 19S3 30.06,85 61 32 20 31.01.8b Yes High Autoclave | Haemang {osarkama. cleaner |Friedel letters 23.12.8b, jib.11.89 6 Fendel Lb.2.89 ___________________ 1_______________________________ -- 32 00.00.30 A H 'ttS 00.04.86 55 30 21 15.07.86 Yes High Polyworker Autoclave cleaner llaemangiosarkcma. Also Developed Cbolangiosarctma. Friedel letters 23.12.86, 15.11.89 and Fendfel 16.2.89 a33 00.00.w 8 1953 19.08.83 67 - s> 00.00.34 4 4 1956 * 2 tJO.OO.24 4 4 196S si w h) 13.06.85 51 38.2.33 49 30 21 25.03.85 Yes 29 16 37.09.85 Yes 5 i 16.10.84 Yes High Autoclave Cleaner, Chemist r| Worker High Shift Leader High Autoclave C Leaner Letter fro* Or Priedel 16.11.89 Utter Iri* Ur Friedel 16.11.89 |97b disease of iivr parenchyma; at ii4Sl LeUer frtm ti* FriecM lb.II.89 J'Uyt! GERMANY Sheet a 1-------t < LIVER Angiosarc , Cases ( heview Hale: 1 Jan 1990) 10 I 12 | COOWRY AID REFERENCE NO JUIC OR INITIALS HATE Of | | FIRST VC t DATE Of | AGE AT mm |company FACT0Gy| EXPOSURE I OlAGNUSIS I DIAGNOSIS YEARS OF I | YEARS OF EXPOSURE TO | EXPOSURE DIAGNOSIS | ) HISTO j j DATE OF | LOGICAL | ESTIMATED j DEATH CONFIRM-j EXPOSURE | OCCUPATION | ATION | LEVEL | | OTHER CAREER HlGHLiGlfTS OTHER corrects 36 00.00.18 1913 19.01.76 57 n 23 14.02.86 Yes High Autoclave Worker Letter fro* Dr Fnedel lb. 11.89 and mfonwtjun frua Dr Tenkhoff Dec by 37 00.00.21 1969 09.06.85 59 16 05.09.86 Yes Laboratory Assistant letter frca Dr FriedeJ lb.11.89 00.00.22 1914 16.05.88 66 34 19 16.09.86 High Shift leader at the autoclaves; later on at the tuahier letter frca Dr FriedeJ lb.11.89 39 00.00.42 1968 00.10.86 44 IB 03.11.86 Yes High Autoclave Cleaner Pension frua 19/4-84 804 later on 1001. Letter frca Dr Fnedel lb.H.89 and uDoraaliun frua Dr Tenkhoff Dec 89 O 3: > o Nl to w  I CMA 0 1 0 7 2 Pag*s V) ITALY Sheet 1 > conmtv ud REFERENCE HO 01 (Od hash wl*anUcr list) 02 2 JIUC Oft INITIALS LG SE LIVER Aogjosarccu Cases - (Review Date: i Jan 1990) ---------------------- 1 ------------------- 1 ---------------------1 ---------------------- 1I----------------------- 11-------------------------- [-------------------- 1 1------------------- 3 4 b6 7 8 9 10 DATE OF BIRTH outrun FACTORY FIRST VC EIMSURE om or ouqusig AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH 15.0t.34 PUSK Kira 00.GO.6b 19.04.71 3t 06 03 16.04.71 Venice 13.11.29 Montedison Porto Nargbera 00.00.57 13.12.72 43 lb 06 27.12.72 I I------------------------- 1---------------------------- 1--------------------------------- 12 | 13 | 14 | 15 | 16 1l I---------------------- 1 HISTOLOGICAL | ESTIMATED 11 l ; i--------------------------------- | OTKUi | OTHtit CQNF1RH1T1GH | EXPOSURE ocormai j cittet | camorrs | LEVEL | HIGHLIGHTS j i I 1|-----------------------------11--------------------------------- 7Te* ( PVC Bag | |Prleery lisiur 1 extruder | faay have been i | Iperlcardiua. 1 j |Hot boao- 1 | jgeneous wlLb 1 | |other cases. Yes 1 1 1 | Polyvarker 1 11 ______________ 1 1 i | | 1____ __ 1* 1 1 \* 1 I ** M 03 14.03.30 Solvaf Ferrara 00.01.S3 10.07.75 55 22 21 10.07.75 Yes High Autocleaner 1972-5 did 8 yrs (1953 a varietf of 61) Autoclani jobs operator including 12 frs (1961 PVC paduny. 72) AN 04 re 20.07.3V MIC Ravenna 00.04.59 00.01.81 43 21 21 30.03.81 Yes 12 yrs - 1 yr - Never cleaned Very High Monoeer operator autoclaves. See paper bf NN 5 frs - CHIAPPIN0 et Noo-soker. Hedlui 20 jrs - al Ned Lavoro Coosuaed Autoclave Vol 6 (1982) little 4 jrs - operator 6 pp 555-563 alcohol. Mo Low other duties AQL. in suspens ion polfaer- lsstion. Ob G Danesla 19.03.37 PAHSAC Mira 00.00.67 07.03.83 Venice 46 ______________1 _______ 16 Area Foreaao in sane Dapt _______: ___________________ 1 since 1975. 1I 1 8 06.04.83 Tes |Nedlui~? |Bag extruder| |Hi^> 11967-1975 | I |S Pagtialuoga jlelei of t joeeaercial | |2 lug 1983 | |0ept 1976- | | 1 11 -- -----------------------------1111 See Hditooi ffed di Lavoro Lb p445, J974. Further details in letter (real Dr Nonlesano of JARC on Apr 1 i 1st 1902Also see Hal ton i and RundineHa in Acta Onculogica Vol 1 I960 pages 3b ~ 49.  PaQtt 20 italt Sheet 2 LIVER ingiosarccaa Cases - (Review Date: 1 Jaa P-f*J) -------------------------- 11 1 2 1-------------------1I---------------------- 11-------------------11-------------------1 3 4 56 1------------------ 1|-------------------11----------------- 7 0 9 to n YEARS Of -------------------------1------------------- ---------------------- 1---------------------1--------------------------------------------------------------------------- 12 j 13 14 t 15 [ >6 I 1 1 1I country ud REFERENCE HO 06 HUE OR HATE OF initials BIRTH GX 21.0h.36 cowunr Montedison FIRST VC FACTORY EXPOSURE Porto 01.10.60 fergben, Venice DATE OF AGE H EXPOSURE YEARS OF DIAGNOSIS OUGWSIS TO EXPOSURE Duansis DATE OF DEATH 06.12.85 49 25 25 13.02,8b HISTOLOGICAL | ESTIMATED | OTHER jcariRmnoi 1 edoswe OCCUPATION CAREER | j OTHERCOMMITS |LEVEL 1 1 |HIGHLIGfTS| 1___ __________ 1 -------------------- 1--------------------------------------------------------------------------- 11 Tea (High PVC | Letters frai Dr Cbiozzini, Venice, |1960-71 wnufacture j 22.09.8/ and Ll.0t.8S |Nedl<a |1971-74 [Luw |1975-85 1 1 ti fears as Autoclave cleaner 1960-71. 14 fears in Control I l l 1 1 1 Room l 1 1971-85 1 L_ ______1 ir07 09.02.26 Noplafan Tterai 1958 21.01.86 60 28 22 05.04.86 Tea 1958-74 Maintained High VC Machinery (not operating or cleaning autoclaves1 1974-80 VC levels NediiB reduced fra 1973/74 Inforation fns La aedicina del lavoro, Italj, Vol 79 No. 1 Jan-Feb 88, and Dr Beoetta, EniChaa. 1 CMA _______ _______ _______ _______ 1 M I'J VI _______ _______ i--  Page 2 t JWU LIVER AnglusarcGaa Cases - (Review Date: 1 Jan 1990) -------------------------- 1 1 2 cotmv urn tEraOKG NO MIC OR oituls 01 Ttaaji Hurl 02 SC 03 vs 3 MK or Rum OI.OR.22 02,08.39 01.09.10 4 oann Mitsui Tbitw --------------------- 1 -- ----------------------- 1--------------------------- -- -------------------1-- 1 i------------------------1-----------------------------1 ii i 5 VICTORY mot* 0 FIRST VC UFQSIM 00.04.S3 7 date or DIAGNOSIS 24.10.75 8| 9 | 1 1 AGE it | YEARS OF DUORBIS j EXPOSURE TO | masks is t 1 1 53 | 72 ! 10 n TRASS or ED0S0BC DATE or DEATH 13 24.10.75 12 13 | 14 | 15 | 16 ---------------------- 11-------------------------i-1--------:------------------- 11------------------------------- 11 1 HISTOLOGICAL ESTIMATED | | OTHER | OTHER coarimtnai EXPOSURE I OCCUPAT10H | CAREER | COMMITS LEVEL j | HIGHLIGHTS j I1---------------------------1---------------------- 1----1-------------------------1-----------------------------1 11 Yen PVC Assoc |)3 jrsauto-) |Japan Tinea saja not [clave ] |25.10.75 k 1 know. |cleaner | [Japanese PVC 1 Japan |l9M - [ |Assoc letters I Tines {assigned to | [of 31.03.78 t indicated [different j 130.11.87 1 oo 25.10.75[work since | | 1 exposures |had ill | | 1 often at |haallh | j 1 3000 w* t>| | j 1 to 1974 l | | 1 |1------------------------------------------------------------------------------1------------------------------- 1 ll 1 lI l Kanegafucbi Osaka Owical 00.11.58 10.08.76 Mitsui Tostsu Moor* oo.o7.es 26.06.85 i_________ __________ _______ 37 | 17 1 1 1 1 I t 54 | 20 1 1 1 1 1 13 10.08.76 Tea Not known |In poljner- [ [Japanese PVC |lsation work) |Association |Including [ [letters of [autoclave | |3l.0J.76& 5 14.09.85 Tea High [cleaning | |30.11.87 |1---------------------------------------------------------------------------- 1-------------------------------- 11 1 ll i |5 fears | [Letter Iron |Autoclave | |0r Nakamira, |cleaner | J Japanese PVC || [Association | | 130.11.87 __________ 1 _________ 1 ______________ 11i-------------------------------------- \--------------------1------------------------- O 3: > o * o Nl M O' LX VCR Angiosarcxma Cases - (fieview Date: 1 Jan 1990) 10 12 U 14 lb country uD rfpfrppti NO JOIC Oil INITIALS DATE Of birth CQHPUn FACTOR? FIRST VC exposure DATE Of DIAGNOSIS AGE AT DIAGNOSIS TEARS Of EXPOSGRE TO DIAGNOSIS TEARS Of | DATE Of EXPOSURE oum HISTOLOGICAL ammmm ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER coMorrs 01 23.12.IS Horde 00.03.50 21.12.71 56 22 21 04.01.72 Hydro High Foreaan A Autoclave supervisor Confined by Dr TtdisEveoseo of NH. At EPIC Htg of 9 June 1974 Mr P Ranynes stated that Ah had been a auaber of a start-141 lean, VCM b PVC were aade id same buildlog. The VCH was aade fraa acetylene o 3: > o SI M > Page LitfR JLnyiusarcau Cases - (Review bate: i Jan 1940) -- 1--------------------- 1---------------------- 1----------------------- 1 1 ti2 3 4 b b 7 3 10 11 12 -- 14 Lb countrt aw REFERENCE no HAW OR INITIALS date of Bum COWART FACTORY FIRST VC UNSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS TEARS OF EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE DATE OF : HISTOLOGICAL DEATH C0KFIMUT10N ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS lb OTHER CttKNTS 01 nog -*.03.40 Hlspavic 'ornliwgi 1 01.02.b4 10.11.09 49 25 a 09.11.S9 Yes High Autoclave Fri* 1.1.7B Cause of death; 12 fears Operator procfcjct loo cil Multiple feditat I fear 12 fears. Latex 1 fear hfdrogae peroxide cerebral tumor rhages. No Metastasis. Letter fro* Dr Logos1, Solvaj, 04.01.90 n 3: > o MO 'vj to 00 t Page SWEDEN LIVER Angi osarcom Cases - (Review Date: l Jan i990) 11----------------------- 1 1 2346 coumv and REFERENCE m NME ON INITIALS MIT Of BIRTH COMPANY FACTORY 01 HU 02 BL 23.06.27 Knaanard Suodsvall 27.11.11 Knaaord Suodcvtll 03 HE 04 At 10,06.10 Uaaaord Suodsvall 16,11.H tr--wrd Suodsvall n 3: > 05 s ttoo 'O 12.03.19 Keaaoord Suodsvall i _________________ i_____________ ___________1 1 6| 7 | ji ri FIRST VC DATE Of | a AGE AT i EXPOSURE DIAGNOSIS | DIAGNOSIS 1 1 1 1 M.06.51 00.01.4i 20.10.70 j | i 00.08.72* | 43 61 1 1 1 1 1 1 1 1 1 1 1 1 00.OS.47 18.03.76 | 65 00.00.46 i I2.0i.77 | 62 1 l 1 1 1 1 1 1 1 1 1 ll.0i.64 22.11.00 1 1 1 | l 61 l i 1 I _______________ i_______________ i ii i i-------------------------1----------------------------- 1------------------------------- 0 1 10 1 II 1 12 j 13 1 14 1 li 1 16 Il I1 I1 11 11 I1 YEARS OF | YEARS OF | HATE OF | HISTOLOGICAL | ESTIMATED | | EXPOSIRE TO j EXPOSURE j DEATH j CORFLRHATIOM j EXPOSURE j OCCUPATION j OTHER CAREER I1 | OTHER j COMKNTS DIAGNOSIS III j LEVEL j | UfGHLiGIfrS III ll< 1 III III 1 IS | la 120.10.70 1 Yes j jPoiruurker | 111111 1 1 1 1---------------------------1------------------------------- 27 | 27 16.06.72 Yes High {VCX | (Hr SjoelUi's 1 {production J | letter of 1 j| |28 March 19/8 1 |J {confirms 8L 1 |J [was a ameer 1 || {worker who was 1 || {heavily 1 1I {exposed, 1 |J | probably even 1 || jaore so than 1 |[ |a noreal 1 J| {reactor 1 I 1 29 | 21 19.03.76 1 i 31 | 31 12.06.77 Ves Yes High High { 11 | Polyworker 11 |l946-1956 | 11 | 11 | [cleaner i1 J 11 [in first 12 1 {polymer- | |yrs of 1 {isation | |e^>loyment bad 1 {worker (12 | |been heavily 1 [yra) A 1956-1 {exposed- In 1 11977 foreman | {1974, liver 1 |(19 yrs) | {abnormality 1 | | {and necrosis 1 | | | diagnosed. 1 | { {Data confirmed 1 | | |In Dr D Byren 1 1 1 11 16 | 16 l22.II.B0 Yes i I High - | | {letter 16.b.// j | j to CEFIC 111 ii i |l964-|9/0 1 |Letler ol 11 | 6 Years (centrifuge j |2nd Rov I9BI 11 | Luw - (operator j Jlrra 11 11 J HI Years | 1910-1980 | j jdrier j |Or Oavol Bfreu | f1 | |upeiatur | | 1-------------------------------------------------1-------------------------- 11------------------------------------------------ 11------------------------------ * Ifi his letter 1st April 1982, Dr Nunlesano of 1AAC says Sweden's National board of OS Health gives 20-02-70 as date ot diagnosis for Case 0L and 15-05-72 for Case 02.  Page UK Sheet 1 COUNTRY AND REFERENCE NO NMC Oil INITIALS DATE OF BIRTH LIVER AngiosarcL&i Cases (Review Date: 1 Jan IS9U) i FIRST VC EXPOSURE DATE OF | AGE AT UIAGN0S1S | U1AOIOG1S YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EKPOSWE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL I (*:CUPATIUN | I i/rm.H CAKfcKH iiiuiiLiurrs I tmu;H iiKtiurr-j 01 UJ 20.04.01 ICI HLIlhouse 04.04.44 03.12.72 (Fox 6 Collier paper sa;s 23.12.72) 26 22 03.12.72 Yes bOO | 1944-7 VOl ( (Fox 6 1947-8 Drier) Col1ier I94B-61 j paper Autoclave [ says opetalur | 21.12.72) L%]-6fc j Drier I lee and liarri l.ajicet 29-06-14 pages 1116-6 (02) Dubious fabrication 03 02.06.37 BP Barr; 00.02.66 00.12.74 37 24.12.74 04 JSN 23.06.20 ICI JUJlbouse 26.1M.M 00.06.79 b9 2b 18 12.10.79 O * *y o v* o -4 o High Nediiahigh Autoclave cleaner | ----------- 1--------------I ISM b [Pre-war Usb Bagging |packer Plant |]9J9-4Sarvf 19bb-6 |vehicle Drier Plant Jaaintenanoe I9b6-fl jl94b-M Autoclave |iish packer worker 19bd fal Chargeband | j | Dt ter | Plant | 1961-/2 | rut tauti J 2/i Plant | Exposure 1 uuled lu 2 66 - S.6S Page UK - Sheet J 1 12 OHJimiV MO) ] HMffc OR 1 DATE OF RtFLRfclrt | INITIALS H1RTII 1 COMPANY 1 l <r~ r | FIRST trr | FACTlJftY | EXPOSURE I JUR Angu Siiraai 1 useb (Rev mu wle: 1 Jem 1990) t a i 9 1 10 u OATF OF TAGfc AT YEARS OF | YEARS OF DATE OF DIAtUKJSiS DIAGNOSIS 1 EXPOSURE TO | EXPOSURE UEATH Nl> 1 1 I US jfiCK J0.UJ.J4 up 1 _| 1 jtUUTf 1 1, t 1 0ti.UJ.61 UO.10.79 1 DIAGNOSIS 1 1I 1 66 2ti 1^ I9.U.79 1 11 1l 1 I1 11 1 11 11 1 11 11 1 11 11 1 11 11 t 11 11 1 11 l1 1 11 11 1 l1 11 1 11 11 1 11 11 i 11 11 1 1 1 06 |0P 1911 w 1 1 1 |Barrj 1 1 \ | 1962 09.01.00 /9 1 I 1 IS 1 12 09.0t.00 1 Il 11 l Il 11 l il 11 1 i i i 07 |Ka 26.04.20 OP i 1 _4 1 |Barri l 1 t 1 | 1963 OO.UO.0O 1 J 60 17 1 1 1 1 | 0.2 13.06.00 i i 1I 1 06 |tmi 0ft.0S.24 OP i i 1 11 {Barry i i 1 1 1 | t9.09.SO 27.lt.01 1 1 1 1 1 67 1 11 I ) 1 1 1 1 26.12.01 i ii 1i i i i i i i i i i o 3. > O o 04 P* J- L .. i i i i i i i i i i i i 1 i i i 1 i i i I I I I I I I i I i i I | i i i 1 i i 1 __ L_______ J__________ L 1 1 1 1 f 1 1 1 1 I t I 1 1 1 I 1 1 1 1 i i i i I i i i i i i i 1 i |j 1 i i i -x_ \2 HISTOLOGICAL t'OKHRHATJON Yes Yes Yes 11 M 1 tSTHUTU) | T" tKPOSURE | IX WAT HI* | oruER CAREER n > | *mit.R { uAWJfTS i.tvti, | | HIGHLIGHTS 1 1---------------------- i i 1 jtuc ttn-l iPolyc leaner i | ml onul ion f j 1404 11 uta l*j(ex i i |hi 1 H Sndh | jihI Dr D fl J Puljrf loor i |UU11 1%0-M i I Hulf i l ('turgehand i I l%4 7(1 i l Charging i l operator i 1 14 JO !2 i t Oner i l operator --------------------1 f jrs l1 i1 i---------------------- ~T--------------------------- 1 {Further |PoJy Fluor i f mtonut ion |Operator i 11409 inm yrs i |Di P H SniLh (Greaser on i fPolj Flour 1 i 1---------------------- (and Or U fl J jutlli<Ms 1----------------- |FoJjcleaner 1 |L%J-S i {Recovery i | Further ml or*- |ation L909 friM |l)r P H S*ilh 6 1 |t*r U R J Uilliai j Yes 1960-1960 1960-61 (1910-1440 I Furl her 600 pfa Autoclave |p|utur Mechanic| information 1960-19/4 a ffm operator isM-mv |thargeaan {autoclave J1940-1960 1Operator on |Acetylene {Product ion J1989 fetm }Dr P N Saith [and Ur D H J |UiJliaas {building jl'feJ-lUH (Shirt {.super visor {autoclave |buildmy {Never c 1earn'd JLli - nJ,. {Plant 1 l l i i i I j l I I I l I I I f l,,.t l ;;u[jei vibui 1 r| | i i i | ijultM' Lives In in:;|*cl (1 m n ________ 1 1 i l I { I i \ _i_________________ i------------ r i Is COWHUY AND REKERBICE HO NAME UN | DATE Of INITIALS | BIRTH EIGP 07.OS.25 Barry 10 04.04.47 Barry US.05.2S BP Barry o 3: > o NJ W JO 24.01.3/ KJRST VC EXPOSURE 15.02.50 27.04.66 I.JYER Angi osaretna Cases - (Review Hate; T Ian 19911) I HATE UK DIAGNOSIS AGE AT DIAGNOSIS YEARS OK EXPOSURE TO DIAGNOSIS YEARS OK EXPOSURE DATE OK DEATH 13 29 24.02. S3 Of 05 S4 37 IS 4.2 16.05.S4 II + HISTOLOGICAL ESTIMATED J il | OTHER CONKIRHATZOft EXPOSUR E | OCOIPATI ON | CAREER LEVEL j | HIGHLJGirrS + Yes Nediimi | Pol yworIter |2 years on I jAiryiomti j Je (Resin Plant. |A Iso prior to other axtftjrrs |l950. 4 years Irak (maintenance. {3 years sot or (car paintshup. \/ years in I (Graving Dock. -I----------------------------- High * IL jpulycLeaner |Heavy goods Informal ion ninths (500|1966-67. |vehicle driver given in ppm). Low-1 Spray-drier (until final letter IS mollis |bagger 1967' |ilines. 10.O6.S4 turn (Wppm). |6S. I Dr ON J Pfediin - (Blowdown I UiIltans 21 months Jstnpper I (200 ppa) (operator I ()9bS-70. i I 19.12.65 02.06.S5 57 19 16 02.06.S5 Yes (High Jpolycleaner jl%5 -69 jl%5-68. jlfed 69 79 (Service |Low 79-S2 (operator |6B-69. ipi>1i |Uperator Ibl-W. | Leading Hand j 1-1-6/. lb.09.5/ U3.Ob.S6 1 1 1 1 j 2fl 06.12.S5 j \a m 15>5 / - >91 Spate aun, (high Vt M (bagging (Low M-S5 ft I'.n 1 l`)LJ/ `.4, |Aullh lave lllJ.-tjtLlJ J____________ -J_______________ (loiter of (04.U6.S5 |Ur Paul Smith (and letter oJ |04.U6.S6 (Ur UNO Evans jOesophageal | haemorrhage |due to (oesophageal |varices due lu J Angiosarcoma jul livei (belter (26 1)6.66 110 K 1 Lee 1 1 t 1 i----------------------------------------------------- Page UK - Sheet 4 1.1 VEK AityhosarciBau Cases - (it*-v i-ew liate: I January 1990) -------------------------- 111 1 111 1------------------- 1-----------------1------------------ 1----------------- 1-------------------1------------------------------ ------------------------------- r------------------------------------------------------------------- 1 12 | J| 4 | > 1 6 1 ) 1 a I4 | HI 1 LI 1 12 1 11 j 14 IS | lb 11111111111L 11 11 T 11I 1 1 1 ------------------------------ 1---------------------------------------------------------------------- I1 I || (years of | | |histu- I j t COUNTRY AMD |NAME OR 1 DATE Of I FIRST VC IdATE Of (AGE AT (EXPOSUREI YEARS OF | DATE OF |L0G1CAL |ESTIHATED | |other j REFERENCE 11N ITl ALS | BIRTH COWANY j FACTORY EXPOSURE |UUAGNUSIS|D1ACN0S1S|T0 |EXPOSURE| DEATH (CONFIRM-(EXPOSURE j OCCUPATION | CAREER I OTHEROmjfTS 11 1 I| (diagnosis) | (ation | LEVEL j HIGHLIGHTS | 11 1 11111 11111 n MJ 02.01.4a BP Barn 1968 Jan 86 37 IB 3 IU2.06.S6 Yes | High Polyc leaner Moved to {Renamed well, working 1 196869 [kerflonitrile {actively, until Jan 1986 | Lou I Central Depot Plant until | left 8P 1983. j : 1 1969-/0 Manager of 1C &j High Poiyfloor |SS Ltd at | 1970-1971 Cardiff Airportj 11983-86 J H GS lb.06.4 BP Barry 07.07.66 21.DS.8T 45 _________ 1 IS BCR 23.OS.2 jsr Barry 1956 1968 1 1 1 1 1 1 66 21 11 01.12.8B Ves 10 Months Polycleaner {letters from Dr LtfJ Evans, High 1966-67 (pathologist, Penarlh, Wales 10 years Polyi luor (and Dr LMJ UiHians, BP, Barry constant Hediua but on worker at lines between 1966-1962 l 1 1 inter* ittent jots ______________ 32 16 01.05.88 Yea 9 years Poly cleaner 6 ) l l l It---------------------------------------------- [luforaat Lon frt High 5 years Operator ) Exposure Blow 6 Recovery) , |Dr 0 H J UiIlians, HP, and . Ur Paul Sailh, Pathologist 1988. Hediia 2 fears Low Operator Utilit, Operator jil--m-t } | | | 1...... 16 RT 25.Ob.2 ICl Hilibouse 1963 1988 66 25 12 12.11.88 Ves 1 fear ) Packer Lou ) 9 fears) High ) 2 fears) Lou ) Autoclave Operator \t RN 14.01.3J [Cl Hiilhouse Ob.04.63 19U9 58 CMA 010733 26 25 17.09.89 Ves 1963-63 Packer Low 2 Months 1963-74 ) High ) Autoclave 1 {11 fears; ) Operator 1974 88 j ) 25 years Ujw j J (14 years ) _________l Hepatic fibrosis 19/4 Oesophageal varices Porta-cavai shunt 19/5 Information frtai Dr B Bennett, JCI, and Dr J J Lee, Blackpool Victoria Hospital 1988. Inloraat jon frua Dr B Bennett ICl, and Dr K J Lee, Blackpool Victoria Hospila 1, 1989. UK sysleni of dal^s USA I.JVER Angiosarccsu Cases - (heview Date: 1 Jan 1990} UAY - HOtmt - YE.AA Sheet I coumtv aw REFERENCE HO 2 HIK Oft INITIALS 1---------------------- ------------------ 1 3| 4 5 |6 -- ---------------------- 1-------------------------- 1-------------------- j 1----------------------------- 1---------------------- 1------------------------ 1----------------------------- 1------------------------------ / a | 9 | to II | 12 ( 11 1 >4 1 15 | 16 DATE Of ____________ 1_____________ FIRST VC DATE OF AGE AT 1 1 | YEARS OF 1 1 | YEARS OF 11 1 I1 Il.lJ HATE Of I HISTOLOGICAL | ESTIMATED 1 1 OTHER | OTHER BIRTH COMPANY FACTORY EXPOSURE DIAGNOSIS DIAGNOSIS | EXPOSURE TO | EXPOSURE HEATH I CONEJRHATIOM | EXPOSURE 1 OCCUPATION 1 CAREER | CUtHEVTS | DIAGNOSIS | j | LEVEL | | H1 UHL 1 CUTS | L___ 11| 11 11111 1 11 1 11 History given [Roiling Stone 11 in Annals NY [Art 01 Earl 17.10.a BTC Louis 09.12.48 03.03.73 49 24 21 03.03.73 Yes | jfutCleaner ACAD SCIENCES jftef 1 NY Acad Parks ville S<maj j(Block Vol 329 (1979)jof Sc Syap [ | 19/4) p 53 page L90 in |l974 11 Paper by |Also Block 11 11 B R Cot tine of[jx*a L.7.74 USHA jp 53 11 1V 11 02 19.08.13 BFG Louis* 15.11.55 00.05.70 37 14 13 27.09.71 las | |Pot Cleaner |Aef 1 villa (NIQSH | (ter Block) [Also Block says ll [JAMA 1-7.74 28.09.71) 1l Ip 53 iI i 03 Eitwrd 25.tft.15 are Louis* 28.11.45 19.12.73 58 28 28 19.12.73 Yes | [Pot Cleaner Louisville Ref 1 j |(Cf Block) Diniddla villa Courier Also Block 11 Journal 11 02-09-60 11 11 04 IS.01.24 are Louis* 0b.07.52 19.08.67 43 15 15 07.01.68 Yes | fPot Cleaner Ref 1 uiile | t(Cf Block) 11 1 1 OS 25.01.12 BFG Louis 19.06.44 09.04.64 52 20 20 09.04.64 Yes | [Pot Cleaner Also Block Ref 1 ville | |(Cf Block) 11 11 1 Ob Ear 23.11.2S BFG Louis 17.01.62 00.02.74 45 12 12 24.07.75 Yes | | US Air Force | Also Block 1 |ftef 1 * Austin Jones? ville || ( j jpot Cleaner | [Louisville [Ties 21.7 /5 | |(Cf Block) | j| j |j | [Retired April [1974 (Also Block 1 07 Diaries 03.05.22 j UCC 11 _______________ _______________ ri js Charle-| 27.08.41 00.00.66 l 4b | 24 _____________ i 17 [23.U3.68 T Saart 1 i ston | 11 1 ------------------ 11----------------------I1 11 1l _________ 11J Ii _____________ 1____________ ir Gtt 06.OS.20 | Goodyear |Niagara j 07.10.46 00.08.61 | 41 | 15 | 15 | 29.08.61 Yes Yes I|j1 111 || | III |1I1 III |J J 1 |Ref J 1 1 | Rei l l Il II 11 III 1 o 3: > _j I II t Il iii---------------------------------------- II II II II !---------------------------------------------1---------------------------U------------------- 1------------------- III 1 III 1 iii________________________________ i--------------------------------------- o o Nl w s USA - Sheet 2 ---------- 1 2 j 4 b6 COUNTRV AMD REFERENCE HO NAME Oft INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE LIVER Angios<ircaaa Cases - (Review Date: l Jan 1990) -- I 7 6i 9 10 11 _____________ ____________ DATE OF DIAGNOSIS AGE AT | YEARS OF DIAGNOSIS t EXPOSURE TO | DIAGNOSIS YEARS Or | DATE OF LXFOGIAE | DEATH 09 Raymond OB.II.3t BFG GettieFinger? Louis* villa 28.OS.45 01.03.74 43 | 29 24 11.03.75 10 16.oa.13 Goodyear Niagara 12.06.51 00.05.60 II 77.05.09 Goodyear Niagara 14.10.46 00.03.70 12 Francis A 17.11.IB Firestone Pottstoun 13.07.49 02.05.69 tectaao Fa 55 | 17 61 t 23 50 | 20 IT 10.05.68 23 16.03.70 19 02.05.69 13 Richard 01.12.21 UCC Eduard Clendenin 5 Charle- 11.12.42 stun 00.05.74 52 | 12 26 07.04.74 n % > -- (15) si w 01 -- ______________ i---------------------- _____________ UK system of dates day - Nmrm - year 1T ll 12 i B | 14 | J11 TT HISTOLOGICAL | ESTIMATED 1 | 15 OTHER it 1 OTHER CONFIRMATION | EXPOSURE | OCCUPATION | CAREER OMSMTS | LEVEL 1 | HIGHLIGHTS j_________ 1 |___________________ 1l Yes | 2000 ppa 1 1 Ref 1 has Il 1l wrong figures re fit st ll exposure. ll Louisville ll Times 1l 25.10.14, ll 12.1.1b, 1 j_________ 1 l 1 1 110.3.16 ___________________ 1 Tea 11 |tef 1 j_________ i i i ___________________ Yes 11 Ref 1 j_________ 1 __________________ 11 1 1 kYes |mgb 10 yrs)10 yrs as |Ut1lit y Ref ] letter |reactor op. jService op. of 26 April |(not cleanerjBagger 1516 fru |- separate |Dryer op. Russell A Park |cre*i cleaned (Stripping op. to J T Seamell |autoclaves) |l yrs prior of MCA i (service In . i {tyre plant 1J_________ 1___________________ ____________________ 11 Yes j 200(1 turn 1 1 Charleston 1l Daily Nail 1I ,21.1.16 j i___________________ ___________________ 1i 1 11 1i 1I 1i 1i Never diag- nosed as ang- jiusarctaa of liver. Intone- 1 1 1 1 j 1 ! i i i J______________j_________ i I I i i 1 l i i f i at ion given in letter 22 Nay 1564 Irua J A Sail). Accountant; ASL - Hu evi dence ol Vtll lexjiusure. Page 3?- USA * Sheet 3 LIVER Aug i osarco Cases * (Review Date: i Jan 1990) UK Systen of dattis DAY - HUHTH - YEAR 1 coumty jub REFERENCE m 16 -- JI 4 |6 2 1----------------------6| 7 ------------------ 11------------------ -------------------- 1_______________ 1 1 HUE OR INITIALS DATE Of BIRTH COWAKY FACTORY FIRST VC 1 DATE Of EXPOSURE j DIAGNOSIS 1 _____________ 1_______________ Jaws 04.11.27 BFG Louis 08.OS.50 00.00.69 AGE IT 1 !9 I ) t I TEARS Of 1 11 1 |------------------------ 1-----------------------------1----------------------------- I 10 1 11 I 12 1 13 j 14 1 15 I lb 111 1 || III i f| |---------------------------- (------------------------------ III II I I | TEARS Of | DATE OF | HISTOLOGICAL | ESTIMATED [ 1 OTHER j OTHER DIAGNOSIS | EXPOSURE TO j EXPOSURE | DEATH | CONFIRMATION 1 EXPOSURE j OCCUPATION | CAREER | j DIAGNOSIS ill | LEVEL 1 1 HIGHLIGHTS ORMENTS 11111I ... ri ii 41 19 [ 04 127.03.69 j Yes | 11 i-------------------------1---------------------------- 1------------------------------ 11951-4 VCTI jtrua 1954 |Table 4 in Hoard ville 1 1J J jpolyner- | inwards iq j Wagoner III | |i sat ion |Aray *d other | Testimony to III j| (service. |US Senate III || J46-50 Any j Confined in 111 III || || | j |N H Johnson Jtr 07.0ft.7ft 17 Peereobooa 06.05.31 BfG Louis ville 23.06.55 11.10.74 43 1__________________________ 1______ 1 1----------------------------- f Yes 19 19 16.10.00 j on 11.10.74 11 1 1 I------------------------- 1--------------------------- -- 11 11 Ur H N Johnson | but no 11 letter of J (U0t-aortea j i6.ia.ao 11 11 24.2.61 con fined death i 11 6 years alter i 11 diagnosis t ----------------j------ 1------------------------- 1---------------------------- 16 Chur lie 22.04.2ft BFG Avon Lake 1S.09.S4 00.00.75 46 21 13 02.11.75 Yes 13 yrs |Mavy j Arthur autocleaoer| | ft yrs <jo Estol || |T|re Store | plaat iciaer | | 6 Carboaet J j operation J ___11 i I | i I 19 Virgil 00.00.15 ucc S Charle 00.00.43 19.OS.7b 60 32 32 06.04.76 Yes 2000 pp* f Christlea ston | | | J j Confined in H N Johnson Itr 07.U6.76 Also Rolling Stone nag. 15.01.76 i I fwiiliausport |Sun Gazette |21 June 1975 20 11.00.17 Goodyear Niagara OO.OO.SS 30.01.76 sa 21 _______________1 ii Ii 71 Chester 02.09.09 UCC Hinkle S Charle-j 00.12.46 slon | Earlf 71 | 1 67 30 11 ___ i1 t1 ____________ 1_____________ _______________1_______________ IS 22 t 30.01.76 02.01.77 Tes Tes J| (charleston || |Daily Hai1 | _ ii I1 11 | 121.7.75 II ii | Indish letter 1 jof 25.10.79 i| lfl| |1------------------------------ III 1 || j |2H frs uilli || || | | |l)CC at SC jlb-Ured || | (News release 11 1 123.2.77 ---------------------------- 1111------------------------------ OiO?36 CHA Pje USA - Sheet 4 LIVER Angiusarcuna Cases - (Review Dale: 1 Jan 1990) UK systen ul dates DRV - IMTTH * YEAR -- -- ---------------------1 ---------------------- 1-------------------1 1 2 345 0 cotnmv ut> REFERENCE NO mm on INITIALS DATE OF BIRTH CGWAJN FACTOR? FIRST VC EXPOSURE 22 02.k0.21 BFG Louis- 11.07.47 villa 21 00.00.21 Great Fitchburg 0B.09.5B American Mass. Cbewucai Cuqwar ---------------------- ,--------------------------- 1 -------------------- 1 7a 9 10 n DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS VERBS OF EXPOSURE DATE Of DEATH 00.01.70 52 29 28 04.12.76 06.M.73 50 15 14 06.04.71 11 1 111 1 1 12 | 13 | 14 | 15 | 16 |__________________________________ _________________ 11 III 1 111 1 HISTOLOGICAL 1 ESTIIUTED 1 1 OTHER | OTHER jcowmanon exposure j occwtrio* j career | cgmchts | LEVEL j j HIGHLIGHTS j |__________________________________ _________________ ___________________ | III 1 Ten | ] | |Louisville jj L jTinea 26.1.76 || || | | [said be was jibe 10th AS |[ J || | || | 1I I 1I 1 || | III J| j J| | 1I 1 || | ||| j| | Ivicttn at |Bells Lane ot jwboa 8 bad Idled by |2b.L.7b |la his letter |tu tb.il4.ttl |Dr H N Johnson | curd i rats (his |is Lbe |case described |by Dannaher [Taaburro A Vn |1 | [u, Feb 198U || || | j |k* J Medicine jvol ;t) p280 1111 fee (24) Dele ed 1000 b) i Bennett: Not angleslarccea, but confined C i SI I 8 (24) o 3: > o t-L o SI u Read *al frn reg ster conf rod in R 1 ______ -- ______ ______ 0) ii er of 5 Nov*tei 1460 _______ ________ t ' ______ R M Wheeler letter of 20/2/79 and Ruse Kaainski letters of A/2/79 and VM/B0 _________ _________ Cage 31! LIVER AiHjiosdn-uaki Cases - (Review Dole: 1 Jdo 199U) UK sjste* of tidies - lJAY - MONTH- YEAH USA - Sheet 5 * 2 1 4 56 / 6 9 10 LL 11 12 LI 14 IS 16 CUATTHV AMU i REFERENCE NO NINE OR INITIALS DATE OF BIRTH cowurv FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION j OTHER CAREER HIGHLIGHTS OTHER CUMEMTS 26 John Berrf 07.07.23 ttfti Louis ville U3.10.47 00.00.77 (up to 2 jeers after death) 52 (death) 2B (death) IB 11.02.76 Yes ' Exposed in Various jobs some degree in PVC to 22 plants from chemicals cold roue to hut main paste exposure recover]* to was to UCH, PVC charging probably operator to high paste charging. Ill August 1965. Terminated e^lofmant Jan 1966 R Kaminski letter ot 26/2/7<J and I'l .it. Taafcurru letter of 9/1/7S 27 J L 11.OS.16 ucc Forrest S Charle 01.07.41 ston 30.11.70 62 37 20 25.11.78 Yes (HIOSH safe 27 and C DaiIf Hail > High Operator to Exposure in R H Wheeler 10.10.76 bulk and Jtr of 4 Jan dispersion PVC 1979 and manufacture Charleston Dull) Nall 30.11.78 and A Kaminski 2b/2/79 28 11.M.17 ucc S Charle 00.0B.44 03.11.7S 61 34 33 01.ll.7fi Yes ston R Kaminski letter of 6/4/79 29 12.10.07 wcc S Charle OO.OS.42 00.03.SO 72 18 16 oi.oi.ao Yes ston R Kaminski Letters of 19th June L98U & 5th Nov 1900 10 Wh 22.0/.22 Teoneco Flemington 11.06.64 30.12.80 SO 17 15 10.12.00 Yes 6 - Unknown Maintenance Chemicals i 9 - MiciLeal Mechanic l 6 irs i nI 3: > I Elsewhere i LJ frs | | i boiler house] oi 1 ____________ i_____________ i _____________ l O I I 1 1 1 _ _ _ i__________ ______________ _______________ _______________ _________________ I Operator __________________ l_______________i 9 yrs |i i| __________________ u 00 Page Jj USA - Sheet 6 1I ___1 1 -------------------------- 1 1 1 axamiY and REFERENCE NO hake or INJTULS DATE OF BIRTH ji 06.11.23 4 CCWANV UCC 1I |5|6 I| 11 | | fIRST VC | PACT0RIT | EXPOSURE 11 |1 11 |s CUrle-l 12.0S.4h t `t<X> I 11 11 1I 11 11 11 11 11 I1 11 11 11 ii UK sjstt* ol dates LIVES Angiosarccna Cases - (Review Date: L Jan 1990) DAY - MONTH - YEAS -----------------------1---------------------- 1-------------------------- 7a 9 ------------------1----------------------------- i---------------------- 1 10 LI 12 1H 1 H [ 15 ! it 1 DATE OF AGE AT DIAGNOSIS DIAGNOSIS 1 1 oi.Gtt.ai i i i i 57 TEARS OF EXPOSURE TO DIAGNOSIS 35 TEARS OF DATE OF Fipnfijpf DEATH 1 1 11 02.04.82 i----------------------- 1-----------------------HISTOLOGICAL | ESTIMATED 1 OTHER -- OTHER COW LUNATION | EXPOSURE OCCUPATION CAREER CUHKIDS ! LEVEL HIGHLIGHTS --------------------i--------- 11 -- 1|------------------------ --' (----------------------------- Yes High (But Chemical From 1959 to I Dr Dacey l not as high|Operator in 1976 Aliphatic(letter l |as reactor (charge Cheaucais 16.10.81 and l Jcleaner reactor operator and R N Uheeler i Ivuuld froai July 197b|letter of l experience)| to date 9.11.81. l Nutted as Foreman lAlso Dr Dacey J labourer Aliphatic 1 letter of i trim Chemical ,01.01.83 re l June 1941 Operatioa date of death. l to IbT I94&| i l and aai I have : cleaned reactors in that tune 32 C U Giroux 22-02-0* Monsanto Springfield 15-10-51 00-07-79 | Hass | 31 II 1 1 II Il 1 II ll 1o 3 >1 iI i I t Il l I1 Il l I I O 1 * 1 II II I I lI Ii 1 , I 1 ^1 iA 1 vO 1 ij I I i i1 I I I It I l i 11 II I ti 1f II I I i 11 II i II 11 Ii i Ii 11 r___ i11___ M S Ferguson |08-10-27 HFG Ii t I i i1 I I i iiiii 1| [Louisville 09-09-54 11-05-82 54 inr J II i Ii ii II I l I 1f tl I ( I ll 11 1 1 i ____ 1___1___1___ 1___1___1___ 1___ 1 28 28 14 17-05-80 An autopsy Itie death 1940-1951 inlonat ion (in PVC was done and certificate Various jobs given in autoclave area) bnediate cause of gave jin polyaer Hr Giroux' |nanufacture tetter of 24 li'ebruari 1982 death given usual iHUrVAR jlrij* Dr as occupation JUISTREl "Angiosarccaa" as "kaUlejlHSI-1%4 |Halter C |Barnes of operator41 [Various jobs [Monsanto i in in and [Springfield to i "chemicals {around PVC [Dr A Nunn ot i |industry". |autociaves |Monsanto i |19M-W1 J kurupe. i |Various i [clerical i i [jobs in PVC i i fpoJ paer isat ion | i i L r 28 Alive _1 (es i |faoilily/ i i jftel ired i [Ul-UJ-M. l i-----------------------1------------------------ ---------------------------- 1------------------------------ ||9M-M |nulUp]e |Prol TdoAmrri) l 1 High | jobs |letter ot 1 I J 1 _.J |l9/5-62 I Low | Kicludiiuj |l'uly 1|l2 tug JLJ2 t Ur n N Johnson 1 | Operate* | letter u{ I____ l ____ IiViVycleanet. | _______ 28 let 198i. t f'age ' USA * Sheet 7 L.JVKJt Angiosarcuaa Cases - (Aeuieu bale: i January 1990) UK systea of dales mmiw - Yl.AH ------------------------- ! ---------------- 1 --------------------1 ------------------1 ------------------,------------------! i -- 2 3 4 56 8 |9 10 *2 13 M 18 16 -- 1 ___________ 1___________ 1____________ ___________1___________ 1 __________ 1____________1 ______________ ii i ri i i i 1 comers v uo UK OR I DATE OF nasr vc DATE OF | |ADE AT | VEERS OF | | |H15TD- | | |FIFOSURE 11 EARS OF| DATE Of |L0G1CAL |ESTUIITED| | jtflHER REFERENCE initials| birth OWANY FACTORY LXWSURt DIAGMUG IS j D1AGN0S IS |TD juPOSUREl DEATH |CWIRN-j EIFUSURE joCCnFATlflH j CAREER cmitR cuwjTs NO l -- 34 Hr Bfna 29-01-34 BFG Louisviil 1955 | jlllAGNOSlsj j |AT]0N | LEVEL j |HlG*.lGmS ____________l___________ 1____________1__________ 1___________ 1__________ 1____________1______________ 1_____________ 11 03-11-82 48 j 27 10 04.08.83 Vas 1988-74 Poly 1968 led Or N H Johnson letter nf J Hov 1962, 1 Hi* Operator t BFG to 28 Feb 1983 and 9 August 19H4. 1 1978-82 Autoclave beccae a 1 Urn Cleaner rler'jymafi 1955-65 35 09-03-12 IICC S Charle 23-07-44 18-07-83 71 | 39 14 18-07-83 Yea High fra ston 1944 to lldtt. | {fed fna | 1955-1958 Or Oacey letter of 5 September 1983. 27-06-32 The GeneralAahUtoiia 11-06-56 21-06-03 Tire and 50 27 27 Alive i Moderate |l956-b6 |labourer j1956-57 (prod helper |l957-7G J operator j1970-75 {electrician j 1975 A W Laundrie letter of 12 Sept 1983: spotted at nodical Kay 1963. Testing cynrorl Hay 1983 37 J Payton 29.08.29 8FG Louis ville 1953 06.06.64 54 38 o 3: > o M lit Products Calvert City (10.02.63 19.01.64 20 06.06.84 Yes High IWorked {regularly [in PYC area {in the {early days teas. |reactor {cleaner |l953-75. I 28.10.63 High | Haemal 1963-19821 progression [frue helper |to senior {operator, {cleaned |reactors, {stripping a |recovery {areas as jweJ1 as {charging J___I__I___I j|jeral4jr. Intonation given in letter 09.06.64 froa Dr H H Johnson Thronbo cytopenia and leukopenia since 19/8. Gold treatment fur arthritis 1976. Uoder Oc's care about 6 Bunths before death, had passed standard physical examination 3 aunths earlier. J Barr letters of 22.10.64 and 23.01.85. USA SJieel ti LIVER Angiosarcoma Cases - {Review Dale: 1 January 1990} UK system of dates DAY HuNTh - YEAR courm u REFERENCE HO ------1--------r 1------------------ 1 2 3I 4 js 6 11 ______7 B 1 9 ____________ 1____________ j j YEARS OF 10 11 12 u M 16 ____________ _______________ ______________ 1 H1ST0- ife UK Oft DATE OF INITIALS Biimi 1 COWAMY | FACTORY lt FIRST K EXPOSURE DATE OF |1GE AT jEIFOSURE YEARS Of 0UGNQ6IS| DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF DEATH LOGICAL ESTIMATED] j OTHER OQNFlSfl- EIPOSWE | OCCUPATION j CAREER ATIQN LEVEL (highlights ___________ 1 ____________ _______________1______________ 1 OTHER COtttENTS - ---- --------- Never in hospital tor any chronic or J Nemice (27.06.18 Pantasote | Passaic I960 ftarch bS 24 23 29.06.84 Yea Lon 29.09.60 - jUorked acute medical problems. Death certificate 1984 |mt 66 before slates cause of death cardiu-pulmonary |injl I960 arrest secondary to angiosarctma of jfabricat ion uith US liver. l j Plant Air Letter of IS.07.86 from John E Ertel 1 High (Hay 66 - Force, of Paotasote with letter of 24.02.86 1 I Aug 70 (hni led from Dr Auerbach, Pathologist. 1 l |UU1U( Wool 1 |Resin Dyers 1 1 (Operator and 1 1 |(1dc Jul 66|0fcanite 11 - Sep 67 11 Reactor 11 Operator) 1 1 Low Sep 70-82 11 Monomer 1 l Operator 1 1 Low 1982-83 1 l Hill 1 Operator, 1 Caleodar 1 Shop, until retirement 40 P P 26.10.14 BFG Gilmer Louisvilie 22.0b.42 1967 72 j ------------------ I 41 ft Buckley 2.02.1b Goodyear Niagara 1949 190/ 72 I Kalis II II lI OI 3: I > I I I I iiil till till ot t-l I o I I NJ I I .fc X X till till lilt j------------------ 1i------------------- 1------------------- 4b 34 1 l 1 i t i1 38 27 I I I i I i l i ! 03.01.87 Yes High Chemical 1942-1974 Murker 1942-46 Letter from Dr Dietz, 8FG, 10.3.87 Low 11975-19761 Foreaan 1 |1996-76 11 ____________ 1_______________ 20.08.07 Yes High 1949-65 Retired la*tiers from Prof Tamburro 1 Ichaucal Op/ 191/ University of Louisville, 1987 1 |Shift Sup/ (Age 62) and Or C A Johnson, Goodyear, 1988 l (Foreman, |lJVC Resin (Product ion t Hediim 1965-/7 1 JiF Plant 1 iLefL KVC area lor b months in I4bb| ------------------- 1----------------- _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 1_ _ _ _ _ _ _ _ _ _ _ _ _ _ 1_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ Page USA Steel 9 LIVES Angiosarcxaa Cases - (Review Uate: l January 1990) UK s;s1'!B ui dates DAY - HURTH - YEAR -- 1-----------------1 ' 234 couwnv aw REFERENCE NO HUE OR INITIALS DATE OF birth COMPANY -------------------1 -- *3 6 78 9 ---- 10 11 12 U ---------- - -- 14 IS 16 l-- FACTORY FIRST VC EXPOSURE YEARS OR tun or AGE AT EXPOSURE YEARS OF DIAGNOSIS DIAGNOSIS 10 EXPOSURE DIAGNOSIS DATE CP DEATH HISTO LOGICAL ESTIMATED CGNTim- EXPOSURE OCCUPATION ATICM LEVEL OTHER CAREER HIGHLIGHTS other a marrs 42 NcHulte 02.05.41 Olio Assooet 00.04.68 00.04.82 41 14 6 09.07.62 Yea High Labourer in Pot area: pot cleanou regularIf Utter fries Or Peter tbaill 13.04.89 43 J R 06,09.21 GeoCorp Aahlabuia 14.04.55 26.li.86 67 Succi (fomerlj Ohio General Tire) 13 26 10.01.89 Yes PVC Resin Retired Letters fries Rof N Johnson, GeoCorp Plant: 01.01.64 06.Oh.89 and 30.OS.09 High ttelntenaoce Cleaner 1.6 fears Shift Nediia Hecbaoic 2 fears Plant Low Electrician 24.10 fears O 3: > o M- I o Nl -bM Page 7>r* YUGOSLAVIA I.1VR Anyiosarcm Cases * (Review Hale: 1 Jan 1990) -------------------------- 1 1 1---------------------1 1---------------- 1------------------ 1-------------------1------------------- 1 1 1------------------1-----------------------1---------------------- III 1 I1 1 t 1 t1 1 1 1 |2 i J| 4 | 5 |6 | V | d |9 10 | It | 12 | 13 | 14 j IS 1111111i 1 1 11 f t1 i1 l1 l1 1I 1 1 11 |YEA*S Of \ |HISTU- 1 11 COWRY UD |lUK OR DATE 0F| | jFIRST VC HATE Of irGE ST j EXPOSURE years or j am of j logical | estimated | j other REFERENCE j INITIALS BIRIN j COMPANY j FACTORY | EXPOSURE OUQUSiS OUOBSlsjlO EXPOSURE j DEATH j CONFIRM- j EXPOSURE jOCCUPATION j CAREER NO j 1 11 jdiagnosis j jATION ILEVEL j [HIGHLIGHTS |i 1 1 ii ii ii 1 11 1 1111 1 1 ii i ii 1 11 1 l1 lb < OTHER GJHENTS ---------------------------------------------------------------------- r i3 YUGOSLAVIA 1 1 11 1 1t l lI 1 1 l1 1 11 l ll m| 1 0S.04.H|Jugo| Split |OO.OO.S3 j If tall j j S9 1 1 20 20 f06.04.73 | Yes 11 | | jSARJC et al paper | [ |tnv Heal Lb Perspective Vul IV. 1 ii 1 02 | f 1 11 1 1 |1 |1 1 11 15.11,31 |JugoJ Split |00.00.50 [Vinll j | 12.07.73 1 1 1 1 42 1 23 11 11 I1 11 18 (12.07.73 | Yes* 11 || 11____________________ 1 11 |VCM | [production j |pp lay-192 _1________ 1 1 im 1 1 1 1 1 1 00 1 1 1 1 t i ii i ii i ii ii ii 21.12.31 |JugoJ Split lliinil j t i |04.06.S4 j 11 1 1 11 i 11 11.01.76 1 1 1 I 1 1 4S | 1 | 1 1 22 11 1t 11 11 11 11 22 |n.01.76 | Yes* 11 11 11 i i *ln his teller of 3 Oct 1970, Dr Spirtas ot i i NIOSH changed the status of Case 02 to VCM i i production e^lofee. Dr Spirtas also i 1 i 1 notified a new Case 03 also a VCX product ton 1 1 worker. |VCM | [Production ] 11 11______________1_-_-_-_-_-_--_------1------------------------------------------------ 1 11 04 | 1 | 1 1 ll.OO.iOjjugo jviall 11 1 |Split j 11 1 tlS.12.SS 03.09.78 j I1 1 48 | 1 1 1 1 20 16 103,09.76 | Yes 11 |1 ii 11 | | [Rose Kaainsfciletter of 19 June tSflU and | | jlARC tetter of 1April 1962 1 11 i ii l 1l 1 t 11 1 ll l l l 1 1 11 1 1l l 1 t 1 1 11 1 tI I I I 1 1 11 1 lI t l I 1 1 11 1 1l l l i j 1 11 1 ll I l l O % > o f* 0 'O > 01 1 11 t 11 1 11 1 1t 1 !1 1 11 1 11 1 11 1 11 t 11 iii ____________ t 1 1 1 1 1 1 1 1 1 1 lI lI ll It It lI i' j| i it i ii i ii ] ii i ii t ii t ii i ii i ii t ii ------------------ 1_______________i______________i___________________________________________________________ 1 Page hO Incidence of ASL Cases Per Annus - By Date of Death 19b5 6 7 8 9 1960 1 2 3 4 5 6 7 8 9 1970 1 2 3 4 5 b 7 8 9 1980 1 2 3 4 5 6 7 8 9 O > O o "4 > Total 1 0 1 0 0 0 1 1 0 2 0 0 1 5 3 2 3 5 8 5 11 11 8 10 5 10 5 3 10 8 8 11 3 7 5 1 S3 TABLE 1 {Review Date - 1 Jan 1990) NOTES 1 Does not include Italian 01. 2 The 1977 total now excludes US24, Cholangiosarcoma: deleted. 3 The 1982 total now excludes G2b Alcoholic Cirrhosis: deleted. 4 Does not include the following who are still alive, so far as known: Frlb and 28, US33 and 36. t Page 'll Distribution of ASL Cases by Country TABLE 2 (Kevlow DciLe - 1 January 1980) USA W Germany France UK Canada Sweden Italy Yugoslavia Japan Czechoslovakia Belgium Norway Spain Total 29 * * ***** 2^ ***** 28 ** 16 13 5 *** 6* 4 **** 2 2 2 1 1 157 ie Western Europe North America Rest of World Total 96 52 9 -- 15/ ___ * Omit ItOl - atypical case of PVC bag extruder. ** Includes Frl5 and 28, US33 & 36, who are still alive, so far as known. *** Includes one monomer worker. **** Includes two monomer workers. ***** Excludes G26 and US 24: deleted. I ChA 010745 Page 117PaLtern of ASL Cases by Factory TABLE 3 (Review Date - 1 Jan 1390) (a) H Europe Of the 96 cases in W Europe, 79 have occurred in ciusters at it) factories. Of the 37 German cases, 34 have occurred in clusters at 4 factories. ASL Cases Dynamit (now Huls), Troisdorf, Germany BP, Barry, UKAtochem (formerly Chloe Chimie, formerly RP), St Fons, France Wacker, Burghausen, Germany Atochem (formerly PCUK) Brignoud, France Kemanord, Sundsvall, Sweden ICI, Hillhouse, UK Solvay, Tavaux, France CWH/Huls, Marl, Germany Lonza, Waldshut, Germany 18 11 11 10 8 5 5 5 3 3 79 NB: There are 32 pre 1962 PVC plants in W Europe; 20 of these have had ASL cases (Ref Table 8) (b) N America Of the 52 cases in N America, 41 have occurred at four factories out of a total of 55 factories. In N America 41 plants have not had ASL cases. ASL Cases BFG, Louisville, US BFG, Shawinigan, Canada UCC, S Charleston, US Goodyear, Niagara Falls, US 15 12 9 _5 11 NB: There are 29 pre 1962 PVC plants in N America; 13 of these have had ASL cases (Ref Tables 9 t 10) (c) Rest of World I The 9 ASL cases are believed to be :ri one cluster ot 4 and Lwo clusters of 2 cases. CMA 0 1 0 7 4 6 Page V, TABLE 4A (Review Date 1 Jan 1990) Latency Periods (Years from first Exposure to Diagnosis) Country No of Cases Total Years Average W Europe Belgium 2 35 17.50 France 28 795 28.39 * Germany 37 765 20.67 * Italy 6 127 21.16 Norway 1 22 22.00 Spain 1 25 25.00 Sweden 5 122 24.50 UK 16 376 23.50 * 96 2267 23.61 H Europe Averaqe America US 39 1002 25.69 * Canada 13 314 24.15 * 52 1316 25.30 N America Averaqe Rest of World Czechoslovakia 2 30 15.00 Japan 3 59 19.66 Yugoslavia 4 9 85 21.20 174 19.33 Rest of World Averaqe Summary W Europe 96 226/ 23.61 N America 52 1316 25. 10 CMA 0 1 0 7 4 7 Rest of World 9 157 174 3757 19. 13 23.92 * World Average Oi the countries with > 10 cases, France, USA &. Canada have an average latency period above wur 1 d average; Germany in U below world average. Page M> (Review Date - 1 Jan 1990) DISTRIBUTION OF LATENCY PERIODS TABLE 4B -------- 0-9 yrs 10-14 yrs 15-19 yrs Belgium Canada Czechoslovakia France Germany 1 2 3 11 14 5 11 20-24 yrs 5 3 10 --! 25-29 yrs 30-34 Yrs 2i 10 4 64 1 n------------ 1 1 II | | Average | 35+ yrs i | Total || Latency ! II || Period II11 ||(Table 4A) nl 1 II 1 II 2 || 17.50 1 1 i \ 11 |1 2 II 13 || 24.15 I 11 1 1 II 2 | | 15.00 L 11 j1 6 2B || 28.39 11 |1 37 || 20.67 Italy Japan Norway 222 12 1 6 | 21.1b j1 3 | 19.bb l 1 22.00 Spain Sweden UK USA 1 1 25.00 2 21 5 24.50 1 5 1 63 - lb 23.50 3 7 9 8 6 b 39 2b. 10 Yugoslavia 4 4 21.20 CMA 0 1 0 7 4 8 TOTAL 2 13 35 37 37 19 14 157 24.03 l Page (Review date 1 January 1990) TABLE 4C LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE MAX POSSIBLE YEAR OF LATENCY PERIOD FIRST EXPOSURE LATENCY PERIOD (NO OF YEARS) ARITHMETIC MEAN OF LATENCY PERIODS 50 1939 49 1940 298 = 37.25 48 1 37,21,37,41 3 47 2 32,38,45,47** 46 3 38,14,32,42,45 4 28,11,24,20,24,34,39, 886 = 28.58 44 31 5 27,22,28,29,37 6 21,29,31,26,28,15,23 30,35 42 7 29,24,29,28 41 8 28,24,34 9 30,26,20,38 559 25.41 1950 26,22,31,19,23,14,33 22 1 19,28,17,28,34,29 37 2 21*,15 36 3 25,23,22,20,31,22, 32,30,23 4 21,21,25,25,21,28**, 22,34,34 1010 24.04 5 22,23,24,14,19,21,27 42 27** 24,28,30,33 6 21,12,27** 32,29 32 7 19,17,15,13,16,28,30 31 8 18,18,15,17,20,29,28 9 16,21,25,27 598 19.29 1960 13,18,21,25,24,25 31 1 15,16,16,16,19,19,12 27 2 13,18,17,12,18,21,26 26 3 16.17.20.21 25,25,26 4 16,17,25 322 18.94 5 11,19,20 17 6 9.18.21 22 7 16 21 8 18,5,18,14 9 13,16 1970 1 17 2 16 3 4 TOTAL 157 CASES 84 14.00 6 VIOLA 3757 * 23.92 157 MALTONI GOODRICH * Aerosol can filler G 03. ** The following are still alive, so far as known FrlS and 28, US33 and 36. CMA 010749 ro O Page (Review date 1 January 1990) TABLE 4D LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF' FIRST EXPOSURE AND GEOGRAPHICAL LOCATION MAX POSSIBLE LATENCY PERIOD YEAR OF FIRST EXPOSURE LATENCY PERIODS IN WESTERN EUROPE NORTH AMERICA ROW 50 1939 49 1940 48 1 37,41 21,37 47 2 47** 32,38,45 46 3 38,45 14,32,42 4 28,44 11,24,20,24,34,39 5 27 22,28,29,37 6 21,29,31,33 26,28,15,23,30,35 42 7 29 24,29,28 41 8 28,34 24 9 30,26 20,38 1950 26,22,31 19 1 19,28,34,29, 17,28 37 2 21* 15 36 3 25,22,32,30,23 23,31 22,20 4 21,21,25,25,34,34 21,28** 22 5 22,23,24,27**24,28 14,19,21,27,33 30 6 21,12,32,29 27** 32 7 19,17,15,13,28 30 16 31 8 18,18,29,28 15 9 16,21,25,27, 1960 13,18,21,25,25 24 1 15,16,16,16,19,19 12 27 2 13,18,17,18,21,26 12 17,20 26 3 16,17,21,25,25,26 20 4 16,25 17 5 11,19 6 9,18,21 22 7 16 20 21 8 18,5,18 14 9 13,16 VIOLA 1970 1 2 CMA 010750 MALTONI 3 TOTAL CASES 96 52 9 * Aerosol can filler G 03. ** The following are still alive, so far as known Frl5 and 28, US33 and 36. Page (Review date 1 January 1990) TABLE 4E PLANT START UP DATE LATENCY PERIODS OF ASL CASES IN SPECIFIC PLANTS (10 OR MORE CASES) NO OF AVERAGE CASES LATENCY PERIOD TR0ISD0RF W GERMANY LOUISVILLE USA SHAWINIGAN CANADA BARRY UK ST FONS FRANCE BURGHAUSEN W GERMANY 1954 12,13,16,16,18,19,19,21,23,25,28,29,29, 5,23,16,34,18 1940? 12,14,15,19,19,20,24,27,28,28,28,29,29, 31,45 1943 11,12,14,21,22,23,24,24,26,28,42,37 (1941?) 1948 9,17,18,28,31,33,18,19,18,21,32 1939 21,28,29,37,38,27,41,34,44,34,47 1933 17,21,22,25,24,13,21,32,30,30 18 15 12 11 11 10 20.22 24.53 23.66 22.18 34.54 23.50 CMA 010751 Page (Review date 1 January '.990) TABLE 4F LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (10 OR MORE CASES) 1 --1 --l | YEAR OF FIRST | TROISDORF [LOUISVILLE SHAWINIGAN | BARRY | EXPOSURE I W GERMANY I USA CANADA 11____________________ 1_______________ 1_____________ | 1939 1 UK _ 1 | 1940 -- ST FONS BURGHAUSEN FRANCE W GERMANY 11 21 37,41 12 47 I3 14,42 38 14 20 11,24 44 15 28,29,27 22,37 16 26,28 29 j7 29,28 24 8 9 1950 1 2 29 24 19 15 31,33 28 28,34 3 23 31 23 25,32,30 4 21,25,34 28 34 21 5 23,28 14,19 27 22,24,30 6 12,29 32 21 7 13 17 8 9 1960 1 16,16,19,19 12 2 18 12 18 21 3 17 4 5 19 6 9,18,21 7 8 9 1970 1 2 5,18 16 18 -------------------1 13 CMA 010752 Page (Review date 1 January 1990) TABLE 4G PLANT START-UP DATE LATENCY PERIOD OF ASL CASES NO OF AVERAGE PERIOD IN SPECIFIC PLANTS(4-9 CASES) CASES S CHARLESTON USA 1939? 24,30,32,32,34,35,37,38,39 9 33.44 BRIGNOUD FRANCE 1950 11,16,18,26,30,25,34,45 8 25.62 SUNDSVALL SWEDEN 1945 16,19,27,29,31 5 24.40 NIAGARA FALL! 1 USA 1947 15,17,21,23,38 5 22.80 TAVAUX FRANCE 1953 19,16,21,26,25 5 21.40 HILLHOUSE UK 1940 28,25,28,25,26 5 26.40 SPLIT YUGOSLAVIA 1950 20,20,22,23 4 21.25 CMA 010753 TABLE 4H t'-age - (Review date 1 January 1390) LATENCY PERIOD OF A5L CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (4-9 CASES) 1-----------------------------1------------------------ | YEAR OF |S CHARLESTON BRIGNOUD |FIRST EXPOSUREj USA FRANCE !- 1 Ii ....... 1939 | 1940 | 1 | 37 2 | 32,38 3 | 32 45 4 | 24,34,39 51 6 j 30,35 7 8 9 1950 1 2 3 4 | 11 i | | | i I1 1 i 26,30 34 51 6I 7| 8 9 1960 1 1 I I | j 18 16,25 21 I1 31 4I 5| 8I 71 ... 11 8j 9I 1970 1 | | 2| _________________ 1______________ 11 SUNDSVALL SWEDEN 1 NIAGARA| TAVAUX FALLS | FRANCE USA | Jr 1 HILLHOUSE SPLIT UK YUGOSLAVIA 1 I 1! 1I 1 27* 1 31 15,23 | 29 1 1 1 38 | 1 19 17 | 28 1 1 1 i 1 1 1 | 23* 1 I i 1 1 1 21 | ....... 25 1 I 1 | 20 22* 1 1 1 19 I t 1 f 28 ------------------ 1 | " 20 11 11 11 1 26 i 1 1 -- |16,21,25 25,26 16 i 1 i1 i1 i ii 1 1 i i! i1 i1 i -----------------1 1 _ _ _ _ _ _ _ _ _ _ _ i_____________ Monomer worker CMA OIO754 Page 57 TABLE 5 (Review Date - 1 Jan 1990) Annual Incidence of ASL Cases (Date of Death) by Geographical Area 1 I 1955 17 I 1961 12 14 17 18 19 I 1970 I1 12 3 4 5 6 7 8 9 1980 1 2 3 4 5 6 7 8 9 Western Europe North America Rest of World Annual Total 1 1 1 1 1 1 5 12 11 12 41 l4 32 64 63 62 72 5 64 5 3 73 62 7 10 1 3 7 41 1 1 1 1 12 1 5 3 2 3 5 38 5 1 11 2 11 8 1 10 5 10 5 3 10 8 18 11 3 7 5 Cumulative Total Key Events 1 2 3 4 6 7 12 15 17 20 25 33 38 49 60 68 78 83 93 98 101 111 119 127 138 141 148 153 Viola Mai ton i Goodrich TOTAL 94* * * 50** 9 _________________________ _____________________ 1____________________ ____________________ 153 ________________ * Omits It 01 bag extruder O x > ** Does not include the following who are still alive, so far ps known: Frl5 and 2B, U3J3 & 3b S G iO tO NOTE: G26 and U324 deleted. Page ,, 1 (Review date 1 January 1990) TABLE 6 ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING It. 01) KEY EVENTS WESTERN EUROPE NORTH AMERICA REST OF WORLD 1955 6 7 8 9 1960 1 2 3 4 s 6 7 8 9 FI G1 Cl C2 US 8 C3 US 5 Cz2 C4,C5,US4,US7,US10 US12.US16 Viola 1970 1 2 Swl G2 N1 ,Sw2,UKl,It2 US11 C6.US2 C7 _ Maltoni 3 G3* C8.US1,US3,US23 Y1,Y2,Czl Goodrich 4 G4,G5,UK3 C9.US13 5 6 7 8 9 1980 1 2 3 4 5 6 7 8 9 F2,F3,G6,G7,G8,It3 Bl,F4,F5,F6,F7,Sw3 F8,F9,G10,Gll,Gl2,Sw4 F10,F11,G9,G13,G15 G16.G17 F12,F13,UK4,UK5,G18 UK6, UK7,G19,Sw5,G20,G21US It4,F14,UK8,G22,G23 UK09, It5, FI 7, B2, G24, G25, G30 UK10,F16,F18,G27,G29,G35 UKU,UK12,F19,F20,G28,G33, G34 F21,UK13,It6,It7,G31,G32, G36,G37,G38,G39 F25,F26,UK14,UK15,UK16 F22,F23,F24,F27,Spl,UK17 US6,US9,US18,US26 US19.US20.US22, C10.US21, US27.US28 US17, US29, US30.US32 US31.US42.C12 US35, US34, US38 US37.US39 Cll US40.US41.C13 US43 Japl Jap2,Y3 Y4 Jap3 TOTAL 94** 50** 9 * Aerosol can filler (G3) ** Does not include the following who are still alive, so far as known: F15 and 28, US33 and 36 CHA 010756 NOTE: G26 and US24 deleted. Page TABLE 7 (Review date 1 January 1990) ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING It.01) " KEY EVENTS WESTERN EUROPE NORTH AMERICA REST OF WORLD Viola 1939 40 1 2 3 4 5 6 7 8 9 50 1 2 3 4 5 6 7 8 9 60 1 2 3 4 5 6 7 8 9 Frll,Frl6 Fr28** Frl4,Fr24 UK1,Fr23 Sw2 Frl,Fr3,Sw4 Sw3 Fr9, Frl7 Frl2,Fr4 Fr7,Nl,UK8,UK9 Swl,UK5,Fr20,G30 G3* G15,It3,G31,G33,G36 G7,G8,G19,G38,Fr27,UK4 G11,G16,G18,G23,G28, G32,Frl5** FR1Q,G1,G34,UK15 Fr8,G4,It2,G2,UK12 Fr6,Bl,Fr22,It7 Fr2,It4,Frl9,Fr21 G5,Gl3,G25,G28,It6 G9,G10,G12,G17,G20,G22 G6, UK6, G21, B2, G29, Fr25 Frl3,Frl8,Fr26,UK7, UK16.UK17 Sw5,Spl FrS.UKll UK3, UK10.UK14 It5 UK13.G35.G39 G24.G37 C3.US27 US13, US29.US40 C2,US19,C11 C1,C5,US5,US7,US28,US35 C4,US3,US9,C12 C7,C9,US8,US11,US21,US31 C6.US22.US26 US1 US12.US41 US 16 Y2, Cz2 US10, US32 US4 CIO, US37 Japl.Yl US18.US33** Y3 US2,US17,US20,US34,US43 US36** C13 US23 Czl Jap2,Y4 US39 C8 US 6 US38 US30 Jap3 US42 70 1 2 Maltoni 3 Total 96 52 9 * Aerosol can filler (G3) ** FrlS, Fr28, US33 & 36 are still alive, so far as known NOTE; G26 and US24 deleted. CMA 010757 ' J,3S (Review date L ,'anuar7 . ;90 i TABLE 3 WESTERN EUROPE PVC PRODUCERS - START-UP DATES vs ASL CASES (OMITTING C-03 S ;-..;p 1 1 1 1----------------------------- i i iSTART-UP| COUNTRY NAME | COMPANY NAME I LOCATION | ASL CASE NUMBER | YEAS OF i YEAR i J________________i ! L93i !'iest Germany 1 BASF 1Ludwiashafen 1 | 1 1st 5;oosure | i . i 333 [West Germany |Hacker 1J |Burghausen | |04,07,11,15,23,24|57,54,55,53,55,69,50,53i 125.31.32.33 155.53 i ; 938 i Italy iMontecatini Ucna 1 1 ._ 1 1939 | Franee J |Rhone-Poulenc/ |st Fons Ichloe/Atochem I |03,09,10,11,14 [46,43,56,41,43, 115,16,17,23,27.23155.41.48.44.54,42 1940 1 United KinadcmllCI/EVC 1 Runcorn (Closed 1948) 1 1 United Kinadoo1ICI/EVC l.HiUhouss_________ 101,04.12,16.17 144.54.57.4 i .63 1945 1 Sweden 1 Kemanord/Nobel [SundsvalKStockvik) 101,02.03,04.05 151.45.47.46.64 1 1946 1 France 1Rhone-Poulenc 1 Roussillon 101 146 : 1948 |United Kingdom|BP Cheo/ICI/EVC|Barr? |03,05,06,07,08,09166,51,62,63,50,50 | 11 1 110,11,13,14.15 166,65,68.66.56 ! IWest Germany ICWH/Huls iMarl 109,10,29 161,61,62. i 1949 1Belaiuo ISolva? I Jemeppe........... . IQU22 158,62 ... . I 1950 |France |PCUK/Atochem |Brignoud |02,04,05,06,12,19|59,49,65,58,49,59, | 11 1................... 120.24 151,43 ._ 1 | France |Rhone-Poulenc/ |St Auban |Q7,22 |50,58 | 1 1Chloe/Atochem 1 11 .1 1 Holland 1 Shell IPernis, Rotterdam 1.. 1 .1 I Norway I Norsk iHerova. Porsarunn 101 150 1 1951 (Switzerland 1Lonza/ICI/EVC ISins. ....... 1.......... ..... 1 "1 1952 |Italy |Montedison/ |Temi |07 158 | 1 1Moplefan______ J___________________ 1 1 1 Italy Iwontediaoo/EVC 1 Porto Harahera 102.06 157.60 1 1953 [Austria lHalvic/Solvay 1 Hallein 1 1 1 [France Isolvay iTavaux 108.13.18.25.26 157.63.63.62.63 1 1 Italy ... Isolvay 1 Ferrara 1.01.............................LSI... . 1 |Spain |Rio Rodano {Hernani 1 1 1 | United !Ongdcn|BXL/BIP/NORSE liycliffe 1 1 1 lest Germany iHoechst iGendorf 118 [55 1 1954 West Germany 1 1 |Dynamit/Huls |Troisdorf |(since 1.1.89) 1 1. J___________________ |01,02,08,12,16,17|56,S7,54,61,55,61, jl9,20,2i,22,27,30|S4,61,62,61,55,51 134,35.36,37,38.39156,68,53,69,54,68___ 1 | ! 1955 Isnain 1956 |Spain [Monsanto Iberiaittonzon____________ 1 Icaiasa | 1 1 1 1 1 ! 1Hisoavic/Solvay1Torrelaveoa 101 164 1 1958 lUest Germany Isolvay 1Rheinharq________ 1 1 I 1960 |Italy 1 (ANIC/SC Ravennaj I/EVC 1 Ravenna 1 104 I 159 1 1 [Meet Germany 1Lonza/ICI/EVC lUalrtahut_________ 106,13,28 [62,60,60 I 1%1 1 Italy iMontedison/EVC iBrindisi.... .. 1 1 1 1962 1965 IPortuaal 1 Franca 1 Italy 1 Italy Icixea |Rhone-Poulenc IPozzi IPensan lOrorto iMontlucon 1Ferrandina lltLra. Venice [ 121 1 105 1 .............. 1 159 1 11 167 _ 1 1966 1967 iHest Genminv lUest Germany 1 France 1Hacker iHoechst lAtochea 1 Cologne___________ 1 1 1 Knapsack! Frankfurt) l05*[60______________________________ 1 iBalan 1 1 iMiranda de Ebro 1 1 _. .... 1 1 1 1968 1969 1Greece lEsso Panoas [Belgium. _ iBadlphll______ 1 United KinadoalVinatex/Norsk iRmanica/RVC iDiavata Salonika 1 Antwerp Istaveler I'-rrur 11 1 | CMA 010758 )j JJ-______________________1 Continued Page Table 8 - Continued WESTERN EUROPE PVC PRODUCERS - START UP DATES vs ASL CASES (OMITTING G03 & It.Oil 11 1 ..... 1 ~~ -- |START-UP| COUNTRY NAME | COMPANY NAME | LOCATION I mill -------------------------- ,-- | ASL CASE NUMBER | YEAR OF 1 1 YEAR 1 1 I i 1 1st Exposure 1 | 1970 1It^lv__________ 1 SIR I Porto Torres Sar i 1 1 lUnited Kingdom1ICI/EVC iRuncom i 1 1 | 1971 ISoain 1Hisoavic/So1vav1Martorel1 i 1 1 1 Sweden iKemanord/Norsk IStenunesund i 1 1 lUnited Kingdom1 BP Chem iBaelan Bav i 1 1 | 1972 1 Finland ! Peltemu | Svartback i 1 1 1 Ho Hand IDSM iBeek Limburg i 1 I | 1976 |France |Soc Art D'viny1|Maringarbe l 1 1 J____________ If CDF) 1 i1 I 1 1977 I Spain 1 Monsanto Iberia1Tarragona i 1 1 | 1982 |West Germany |ICI/EVC |Voslapp l 1 1 J____________ J________________________________ 1 W-i 1 he 1 mgha-TOTi_______ i _________ _________1___ i 1--------------- 1-------------------------- 1----------------------------1111 * Laboratory worker in Research Department CMA 010759 TABLE 9 Page , ' (Review date 1 January 1990) USA PVC PRODUCERS - START-UP DATES vs ASL CASES r -- 1 START-UP company name | LOCATION 1 | ASL CASE --"1 YEAR OF 'TEAR 1 1 NUMBER 1st EXPOSURE 1939? *ucc | S Charleston |07,13,19,21,27 44,42,43,46,41 1 128,29,31,35 44,42,46,44 Dow [ Midland (made | 1 Saran copolymer) | 1940? *BFG 1 Louisville |01,02,03,04,05, 48,55,45,52,44, 1 [06,09,16,17,22, 62,45,50,55,47, 1 126,33,34,37,40 47,54,55,53,42 | 1946 *UCC/Dow i Texas City (Partially closed 1977) 1947 1948 Goodyear Firestone/ I Niaqara Falls | Pottstown 108,10,11,20,41 46,51,46,55,49 |12 49 I Occidental Uniroyal 1 | Painesville 1 | 1 (closed 1975) | 1950 Monsanto | Springfield j 32 51 1 (Closed 1975 | 1952 Dow 1 Midland (No PVC since c 1975) BFG I Avon Lake 118 54 1953 Diamond/BFG 1 Deer Park 1 1954 General Tire/ ** | Ashtabula |36,43 56,55 DiversiTech 1(Closed 1983. Reopened 1986 by Vyqen) 1956 Air Products I Pensacola (Pace) | Atlantic Refininq I Brooklyn(Closed late 1960s) | Borden 1 Leominster (Closed 1984) Conoco 1 Hebronville (Closed 1975) BFG I Niaqara I Great American | Fitchburg |23 58 Plastics 1 (Closed 1983) | Hooker 1 Hicksville (Closed 1980-81) Pantasote 1 Passaic(Closed 1984) 39 60 1957 Atlantic Tubing 1 Cranston (Closed 1967) Tenneco/ | Flemington NJ |30 59 Occidental 1 (Closed 1985) [ 1958 Keysor Century 1 Saugus, cal 1 Air Products | Calvert City(Paducah) 38 63 1 (Closed March 1982 Re-opened October 1983) 1960 BFG | Long Beach, Cal (No PVC now. 1 Formerly shown as Watson) Borden 1 Illiopolis I 1962 Tenneco/Occidental 1 Burlinqton NJ | 1963 Conoco/Vista I Aberdeen, Miss 1 Stauffer 1 Lonq Beach, Cal (Closed 1982) 1965 Conoco/Olin | Assonet, Mass | 42 68 I(Closed by Olin 1975) Ethyl 1 Baton Rouqe (Closed 1984) 1966 Diamond/Georgia | Delaware City | Gulf 1 ... 1 Gen Tire/Pantasote 1 Mt Pleasant W Va |(Closed 1982) BFG 1 Henry, 111 I Stauffer/Formosa 1 Delaware City (Sold to Formosa 1981) 1967 Allied/Robintech/ | Painesville, 0. (No PVC made by Robintech. Georqia Pacific I GP converted to polystyrene) Hooker/Occidental 1 Burlington NJ 1 1968 Firestone/Occidental Perrwille (Closed 1982) | t < Continued CMrt 010760 Page :7 TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES vs AST. neve START-UP YEAR 1969 1971 1972 1973 1974 1975 1979 1983 1986 COMPANY NAME BFG Goodyear/BFG Conoco/Vista Mat Starch Borden Atlantic Tubing/ Tallvrand Shintech Certain-teed Georgia Pacific/ Georgia Gulf Tenneco/Occidental Firestone/ Occidental Formosa Vygen ** LOCATION ASL CASE NUMBER Pedricktown NJ Plaquemine Oklahoma City Meredosia. Ill Springfield Cranston RI (Closec1 1982) Freeport. Tex Lake Charles Plaquemine, La Pasadena. Tex Addis (formerly sh<Dwn as Plaauemine) Point Comfort. Tex Ashtabula. Ohio YEAR OF 1st EXPOSURE * My databank has no information on UCC before 1946 or BFG before 1950 ** Refer to same plant at Ashtabula, bought by Vygen from DiversiTech. MB Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product. CiMA 010761 Page ;' TABLE 10 (Review date 1 January 1990) CANADIAN PVC PRODUCERS - START-UP DATES vs ASL GASES START-UP YEAR COMPANY NAME LOCATION ASL CASE NUMBER YEAR OF 1st EXPOSURE 1943 (1941?) Goodrich Shawinigan (Formerly Gulf) (Formerly Shawinigan Chemicals) (Formerly Canadian Ressins & Chemicals) 01,02,03,04,05 44,43,41,45,44, 06,07,08,09,10, 47,46,61,46,53 11,12 43,45 1951 Monsanto La Salle (Closed 1' >75) 1957 Goodrich Welland (Niagara) 13 57 1966 Esso (Imperial Oil) Sarnia 1979 Diamond Shamrock Alb/ Fort Saskatchewan BF Goodrich CMA 010762 Page TABLE 11 (Review date 1 January 1990) EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES 1------- --1--------------------------f------------------------- |START-UP| COUNTRY NAME | COMPANY NAME 1 YEAR...1............... 1 tP-re 1939tEast Germanv 1 State Comoanv 1 1941 1 Russia 1 State Cobds 1 1950 1 Yugoslavia liugo Vinil____ i | LOCATION 1 1Schooau 1 Vladimir et al Isolit i i ASL CASE i NUMBER i i 101.02.03.04 '-- | YEAR OF 1 1st ExDOSure 1 1 153.50.54.58 1 .1951 1 Czechoslovakia!State Comes 1 1955 lEast Germanv 1 State Conros 1 1956 1 Rumania 1 State ComDS iNovakv iBitterfeldt 1 leechim 101.02 1 | 157.50 _1 1 | 1957 1 Poland 1 State Comps lOsweicim (Dworv) 1 1 |Rumania | State Contis |Timaveni 11 llurda 1 1958 !Rumania 1 State ComDS 1Risnov 1 1959 iHunsarv 1 State Comes 1 Barents Borsod 1 1961 1 Rumania 1 State Comos iBorzesti 1 1963 1 Yugoslavia lOhis ISkooie 1 1965 1Bulgaria I State Comos I Varna 1 1967 1 Poland 1 State Comos iTamow 1 1969 1 Russia 1 State Comos iDleriinsk | 1970 1 Rumania 1 State Comos iRimnicu Vilcea 1 Russia 1 State Comos 1 Volgograd 1 1972 1 Yugoslavia____ IVinilnlaatika 1 Zadar | 1975 1Czechoslovakia!State Coups____ lNeratovice 1 Russia ! 1976 1 Yugoslavia 1 1977 1 Rumania 1 1 State Comos IfCaluxh Area iHio 1Pancevo 1 State Comos 1 1` Vilcea___ 1 1 1 1 | | | | | | | | | | | | 1 1 .I __L 1 1 1 1 I 1 1 1 I L 1 __L 1 1 1 | | | | | I | | 1 | | | | | | | | | | | | 1 | 1 CMA 010763 Page (Review date 1 January 1990) TABLE 12 JAPANESE PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP YEAR COMPANY NAME LOCATION ASL CASE NUMBER YEAR OF 1st EXPOSURE 1950 1951 1952 1951 1955 1956 1957 1960 1964 1966 1967 1968 1970 1971 1973 1974 1975 1977 Chisso Corp Kanegafuchi Kag Tekkosha Mitsui Toatsu Mitsubishi Mon Sumitomo Kag Denki Kagaku Nippon Zeon Toa Gosei Ryo-Nichi Nippon Zeon Nisshin Kagaku Kureha Kasei Shinetsu Kag Denki Kagaku Kanegafuchi Kag Chisso Corp Tokuyama Seksui San Arrow Kagak Sumitomo Kag Ryo-Nichi Shinetsu Kag Chisso Corp Denki Kagaku Kanegafuchi Kag Kawasaki Yuki Mitsui Toatsu Nissan Kagaku Shinetsu Kag Tekkosha Asahi Glass Toyo Soda Central Kagaku Tovo Soda Unknown Minamata Osaka Sakata Nagoya Yokkaichi Kikumoto Shibukawa Kambara Tokushima Uozu Takoaka Takeo Nishiki Naoetsu Ohmi Takasago Chiba Tokuyama Tokuyama Chiba Mizushima Tokuyama Mizushima Goi (Chiba) Kashima Kawasaki Sakai Chiba Kashima Yokkaichi Hayatsuki Sakata Yokkaishi Kawasaki Yokkaichi Kashima 02 01. 03 58 53. 65 CMA 010764 Page (Review date I January 1990) TABLE 13 SOUTH AND CENTRAL AMERICAN I'VC PRODUCERS START7UP YEAR 1953 1954 1955 1956 1960 1961 1965 1966 1967 1968 1970 1971 1975 1976 1977 1978 1979 COMPANY NAME Monsanto Mexica Policvd Geon Do Brazil Elchlor/Solvay Electrochlor Viplastic Indupa PET Columbiana Carburo De Col Plasticos Omega S0C Paramonga Primex Policasa Petro Dow Polimeros Hex Rico Chemicals Petroplas Indust Resistoc Huls Brasil Polychem Policvd PET Camacari LOCATION Lecheria (Mexico) Mexico City (Mexico) Sao Paulo (Brazil) Sao Caetano (Brazil) Capitan Bermudez(Argentina) Mendoz (Argentina) Cinco Saltos (Argentina) Cartagena (Colombia) Medellin (Colombia) Mexico Paramonga (Peru) Puebla (Mexico) Managua (Nicaragua) Conception (Chile) St Martin Puebla (Mexico) Guvanilla (Puerto Rico) EL Tablazo (Venezuela) Tlazcala (Mexico) Cubato (Brazil) El Salvador Coatzacoalcos (Mexico) Camacari Bahia (Brazil,* ASL CASE NUMBER YEAR OP 1st EXPOSURE - CMA 010765 Page (Review date 1 January 1990) TABLE 14 AUSTRALASIAN PVC PRODUCERS START-UP DATES START-UP COMPANY NAME YEAR Mid 1950s ICI Australia 1960s B F Goodrich Late 1970s ICI Australia LOCATION Botany, Sydney Melbourne Laverton Melbourne ASL CASE NUMBER YEAR OF 1st EXPOSURE OiO7^ \ Page (Review date 1 January 1990) TABLE 15 MIDDLE EASTERN PVC PRODUCERS START*UP DATES START-UP DATE Sept 1986 COUNTRY NAME Saudi Arabia COMPANY NAME LOCATION National Plastic Company (Ibn Hayan) Arabian Petrochemical Company Madiant Al-Jubail Al-Sinahyah 010767 Page ik (Review Date 1 January 1990) TABLE 16 NUMBER OF FACTORIES IN THE MORTJ) PRODUCING PVC So far as known at i .Tnnnary 1990 (See Tables 8-IS of this ASL Register) Western Europe USA Canada Eastern Bloc Japan South and Central America Australasia Middle Bast CLOSED 1 20 1 - 22 OPEN 53 30 4 23 36 22 3 1 172 CMA 010768