Document jGe44QK1Zj5jJY4qoKzK62LQ

Castleman File: American Petroleum Institute w/c = with cover letter or memo If DATE = 0, undated CD-ROM Document #:API DATE fiuej __ published article from trade journal __ published advertisements __ newspaper article __ published government report __ government inspection results __ unpublished or internal report __ unpublished presentation from conference __ letter __ memorandum __ industry warning labels __ industry sales literature __ industry recommended practices meeting minutes (with attachments) __ membership list BC notes 4 January V, 19*9 r. Robert a. Brim Battering Laberatary of Applied Phylology Callage of Medicine nnlTwralty of Cleelanatl Cincinnati 19, Ohio ^ ' Soar Doctor taboo: I at r--1 m1i1 of the prorlalane aot forth la the lattar f agrocaoat dated Jam 15, 19*8, Whereby 00 agraai to jay the Unliorelty of Cincinnati a Nil anna of $25,000 on January 1, 19*9 tad tho Qniforeity agree il to rotsra aay nm tiring la tho fnad on Jam 30, 19*9. It la ay wlai etmellef that clrnaatiiroi boyoad the oeahtl of tho Oalvovaltj here delayed tho aorfc planned for tho period Jam 90, 19*9 aad that It aay bo pooalblo that tho $65,000 realtted hgr lattar dated Jaly 6, 19*8 aay bo oafflelaat to cerar all oacpaaditBroa for tho period. XT thla la troa yoa aay faol It will bo lll^ll^Baa^J for aa to and yon tho $25,000 ahloh la aov dao aod payable. . A otate--rt ef yocr nlehee la tho aatter- irill bo appreciated. . Vwy trnly years. UTS: 4 ec: Mr. Laaoy wnllar Sr. Heitor Woody API 04822 *- Standard Oil Development Company Research and Development Department 15 WEST 51ST STREET, NEW YORK 19, N. Y. u p-ISt-HF.R MANAOKH January 7, 1949 Hr. D. V, Stroop j^aerican Petroleum Institute 50 West 50th Street Hew York City pear Mr. Stroop: You will recall that among the recommendations adopted at the meeting of the A.P.I. Medical Advisory Committee Sub-Committee on Carcinogenicity on November 11. 1948. at Chicago. Item 4 (appear ing in the minutes) reads as follows: "That the fundamental chemical and physical studies that are indicated to investigate the operational technical aspects of this problem may require considerably more money than anticipated; and it is recommended that the technical advisers group consider the problem again and present their recommendations to the Sub committee on Carcinogenicity.* In this connection, Hr. Mclver Woody, Chairman of the Sub committee on Carcinogenicity, has written me as follows: *Now that Dr. A. Wesley Horton has been selected by Dr. Kehoe to investigate the chemical aspects of the problem, it will be greatly appreciated if you would oall a meeting of the technical advisers to confer with Dr. Horton on methods of selecting samples for future testing, tsdcing into account the nature of the crude, its source, the temperature conditions, etc." As I understand the situation, it is desired that the tech nical advisers redefine the objectives of the program to be co ordinated by Dr. Horton and aid him with the selection of suitable samples for study by the Kettering laboratory of Applied Physiology, University of Cincinnati, College of Medicine, under the direction of Dr. R. A. Kehoe. API 04823 T Itr.D.V.S. v -2 m i 1/7/49 I shall be glad to conduct this meeting In response to Dr. Woody's Invitation and would suggest the date of January 31, 1949, In the A.P.I. Board Room on the 20th floor at 89 RuihafellBi piarg, New York City, at 10:00 A.M. Since the group will wish to arrive at definite conclu sions and recommendations. It is hoped that the technical advisers will find it convenient to attend this meeting in person. If you are in agreement with this method of putting Into effect the recommendation adopted by the Medical Advisory Com mittee, I shall appreciate your extending an invitation to Dr. Horton and the associate members of the Medical Advisory Committee to attend this meeting and to others who you feel would be in terested in participating in the discussion. Please advise. Very truly yours. HGMPtHC CCsDr.McI.Woody Dr.J.P.Holt 1 API 04824 \ UNIVERSITY OF CINCINNATI CINCINNATI 19. OHIO UAiOWTORT OF APPLIED PHYSIOLOGY OF MEDICINE--EDEN AVENUE January 12, 1949 (via air mail) CABLE ADDRESS: KETLAB. CINCINNATI TELEPHONE: UNIVERSITY 2665 Mr. D. V. Stroop, American Petroleum Institute, 50 West 5Cth Street, New York 20, New York. Dear Mr. Stroop: In reply to your letter of January 10th, I shall plan to attend the meeting of the Sub-Committee on Carcinogenicity on Monday, January 31st. Very truly yours, 4 AWH:fe A. Wesley Horton' API 04825 Esso Standard Oil Company Medical Department Esso Building. 15 West 51st Street. New York 19. N. Y. ,rR WOODY. M. D. "'"'TO" . s DENHOLM. M. D. J1)H> JurvVT MBOICAL DIItCTOI * T l. SIM. M. D. PBVHIC1AN p LEONE. M. D. ALBERT C. ORUNOW, M. D. CLINICIAN CLYDE M. BERRY. PH. D. induvtiual byoikniut January 12, 19*49 Hr. 2.V. Stroop American Petroleum Institute 50 Vest 50th Street Hew York 20, S.Y. >ar Mr. Stroop! A special meeting of the Subcommittee on Carcinogenicity will be held ir. Room 1000, 15 Vest 51st Street, Rev York City, at 900 A.M. on Tuesday, February 1st, 19*4-9 I hope you can arrange to be present, especially as both Mr. E.3-.M. Fischer and. Dr. A. Wesley Horton may have something interesting to tell us. I HcIWsEH Very truly yours, API 04826 i4 UNIVERSITY OF CINCINNATI COLLEGE Or MEDICINE CINCINNATI 10, OHIO LABORATORY OF APPLIEO PHYSIOLOGY January 12, 19^9 Mr. D. 7. Stroop, The American Petroleum Institute, 50 West pjth Street, New York City 2^. CABLE ADDRESSi KETLAB. CINCINNATI TELEPHONES UNIVERSITY 16B Dear Mr. Stroop: Thanks very much for your* letter of January A to vhich I am glad to reply. I have checked up on our expenditures up to the present time, and I have considered carefully our probable expenditures during the first half of the year 19^9. It seems quite clear to me that ve shall not be able to carry out the extensive work that would be desirable between now and June `0, 19^9. We shall do the best we can, but even so it seems quite clear to me that the funds now in our hands will support our work adequately until July 1. There is no necessity, therefore, for your sending us the additional $25,uGu.0d at this time. I anticipate that we shall be able to gat our work well under way before July 1, and certainly the sums previously agreed upon will be required to conduct the work properly after July 1. With kindest personal regards, Cordially yours, I.AK ef C .C .: Mr Lacey Walker Dr. Mclver Woody (jtiuJhoP.obert A. Kehoe, M D- Il , API 04827 1! January 20, 19*9 Mr. Jcto S. Soma Standard Oil Co. (Bow Jersey) 30 Eochefeller Plaxa Hov lock 20, B.T. Boar Mr. 8am: Far your filo Z mm returning herewith the BmarnrsnrtTin (1-13-*9) frcn Bootar Page, which you handed to am in Washington on January 13th. It now AafTslopa that fir* sanhirra of the API Nodical Advisory Ccantttee bora been invited to sttoad the Bstloasl Cancer Confaranoe In Maaphla, February 25-27, 19*9. AH, or noot, of these ambers will attend a asetlag of ths API Snhniflttee on Carcinogenicity to he held on Fehnwrry 1st. At that tins ths subject of Doctor Fags'* aaaoraa&m will he discussed to a conclusion which will he Ira i wit toil to you* Tory truly yours, BTS:d Suelosur* ce: Mr. VUllan B. Boyd, ft. API 04828 * s i - \ ' -! | .'* 1 4 ' 1A3A? It has Just tew teooght to mj attention that tte Chalraaa of tte Nodical Advisory Creep of API tea boon sated to participate la tte Aanrlew Cancer society Mooting la stick tte Podaral Oovanaoat vill aloe taka pert. It so happens that Jersey has already tew teea^ht lato tte pletnre. Ite Aaarleaa Canter Society gronp have laaraod throogh sow eteanol that Joreoy has tew taking w sws ratter axteaalve rosoaroh w tte heavy catalytic oyolo gas problem. fe fact, Ur. felt has already boon ashed to participate la tte forthsoaiag Ansrloaa Cancer Boelety asstlag Assorting to oowltaanta that ns hgve nade, It sews nest probable thattenlll have to participate. glass it Is probable that tte tear! can API nay be ashed to sate a statwant to tte~jress relative to tte oaacer problw as rolatsd to tte ps>n1jih Tihlashrjj this natter la being brongkt to year attantlw nsv. Mr* Streep sill wdwbtedly give yon all'otter yartlawt details. -- 5j 1 " ' *> 11" - r C vl>"i C . r V 2 j .' $ " '. -- ! l.i; Ir. lobort C. Pago ( o o y i) API 04829 44 Standard Oil Company \A-NIS ' Zf DIRECTOR of research Research Department Whiting Research Laboratory P. O. Box 431, Whiting, Indiana January 26, 19U9 API Medical Advisory Committee / Mr. D. V. Stroop American Petroleum Institute 50 West 50th Street New York 20, New York Dear Sirs Replying to your letter of January 10, I regret to advise it will be impossible for me to attend the meeting scheduled for Monday, January 51> 1?U9 ' Very truly yours, . W. ADAiS EIA/lsg cc H.G.M. Fischer . P.S. I aa greatly interested in the decisions and recommend ations which will be made in this meeting and trust that you will send me a copy of the minutes. E.W.A.  mihutbs SUBCOMMITTEE OH CABCIHOOBnCIIT February 1. 194Q meeting of the Subcommittee on Carcinogenicity was convened at 10 A.M., Tuesday, JeDruary lit, 19^9, at 15 Meet 51st Street, lew Tori: City. fgwBTBS FBXSXHT: I.H. Trank I,1. Hoag J.P. Holt T.J. Kelly T.B. Levis M.fl. levquiet C.A. Swan Mclver Moody .X. Dooley H.O.M. Tiecher H.P. Lankelma K.3. Mackenzie E.B. Marrick H.B. Vilson (representing H.H. Zuideaa) TISHCBSt_ B.C. Cole l.V, Horton - University of Cincinnati D.T. Stroop - American Petroleum Institute TOTAL DT AITEHDAHCZ - 17 jpniBBS iBSEHTl L.E. Curtis L.C. Beard B.S. Bonsib A.J. loewing, Jr. Hr. Tiecher, reporting on the January 31st meeting of the technical advisors of the Subcommittee presented the following objectives for discussion! 1 - Xstablish in what crudes and fractions thereof, compounds are present that may have carcinogenic properties and the types of processes that stay either concentrate or create them and, if so, under what conditions. 2 . Xstablish analytical procedures to permit distinguishing between fractions that according to biological tasting possess carcinogenic properties and those that do not. It would be helpful if a carcinogenic index could be devised for a refiner API 04831 i i 11r t tl I1 to evaluate the degree of carcinogenicity of materials and products* vas agreed that the foilwing processes and materials should he studied: It cfBAlflHT THERMAL PUfyrmggTR; Qas oil cracking Viscosity breaking of residues Haphtha reforming Coking fos reversion Steam cracking CATALYTIC PROCESSES: Houdry TCC ICC Houdryflow Cycloversion Hydroforralng Desulfurization (marginal case) SPECIFIC PRODUCTS: Sod waxes . Slack waxes Certain raw lube stocks (untreated) Solvent extracts (furfural* phenol, sulfurdloxide) Acid oils from acid sludge (marginal ease) PRODUCTS 1B0H OTHKB IKDUSTHIES: Coal tar Vater gas tar Shale oil - domestic and British sources. tossy will make available to Dr. Eorton all its available data and information and It it to be hoped that other companies will do the same. Sr. Horton reviewed the Kettering laboratory report which was distributed to the ushers last Vovember* pointing out that the findings contained in the body of the report are based on histological study of tissue sections, as well as on gross observations, while the graph, which was prepared earlier, is based on gross observations only. He was requested to prepare a summary of the report, including o revised graph showing cancers as determined by histological examinations and the pads of malignancy. ' &r. Horton then reported on the status of the building program at Kettering laboratory, saying that adequate space for the chemical laboratory should be avail- oble by April let; eM the rooms should be ready for use about June 1st. Dr. Holt described the meeting to be held in Memphis February 2bth to 27th under jbe sponsorship of the American Cancer Society and the Xatlonal Cancer Institute WSPBSjj at which Dr. Hoag, Dr. lewquist, Dr. Woody, Mr. Fieeher and he will be sbers of the panel on environmental cancer. Recorders will take down all that Md in the panel discussions, have it mimeographed for use of the participant -2API 04832 t ^0 next sees ion; and the moderator of each panel will present a summary at the * oeral meeting at the close of the conference. The proceedings of the meeting ^ll be published in the Society's magazine and other journals. Tff, Hoag was glad that the petroleum industry is being represented so that in durate statements may be corrected. He cited as an example the tendency of ^informed persons to say that refined paraffin wax produced cancer. He felt g^t the various companies should try to get the facts to the employees and said that he is preparing an article for Socony's employee magazine titled "Some Things Tou Should Know About Cancer", and including some discussion of skin cancer. gf. Cole was of the opinion that all these recent developments were forcing the petroleum industry to take action. He suggested that all API companies should institute the indicated control steps soon. Dr. Kelly reported that a bulletin Environmental Cancer" has been published by the national Cancer Institute and is available from the Superintendent of Documents, Washington, D.C. at a price of twenty cents. Dr, Drank reported that local management was supporting his medical program and that more information (possibly including pictures) from the API would be helpful in informing management more thoroughly of the problem. Dr. Swan stressed the importance of any publicity or Information being accurate and oomple te Dr. Levis said that in the matter of giving out information it was essential to he factual and to create the opportunity for its release. Nr. Stroop believed that the publicity problem was not so disturbing; that the API had a good defense against possible misstatements because of the Investigations now in progress by the API and the individual companies. Dr. Mackenzie said that with the Cancer Society now. in the picture, added weiit would be given to the problem. He cited reports on Incidence of skin cancer among various groups and recommended that in all information releases, the complete story be given to show that there are other things than certain petroleum products which may cause skin cancer. Dr. Bewquist recommended that the statement now on file with the API be reviewed and brought up to date if necessary. Dr. Holt pointed out that in his opinion, and it was the view of the Jersey Company, that the employees should be told that a potential hazard exists relative to the handling of high boiling oils, and that reasonable precautionary measures should be Instituted to prevent skin contact and ingestion of these materials. Ihese views and suggestions are based on the biological and experimental results which have shown that these materials cause the development of cancer when applied repeatedly to the akin of mice and other animals. Dr. Hoag said that Socony has started an educational program by firet informing local plant doctors who, in turn,are gradually telling foremen groups and the toployees about cancer, including skin cancer. He said that the men have been tol& to go to the aedleal department when they notice warts or other skin lealone, w Sovquiet vae of the opinion that it would he inadvisable to single oat the *"1, <kin cancer and that it would he better to tie it is with other conditions. * examination directed toward akin cancer should he tied is with the periodic 0xa*lBAtlons. Hf, Tischer pointed out that with precautionary measures in effect, such as tagging jiges and tanks, provision of showers, emphasis on personal hygiene, the men will why. If they are told merely that the materials are Irritants, they may bec0Ss careless and not follow the precautions. Hr. Tischer, in response to a request for information, said that, while not all fractions boiling above 700 T. were carcinogenic, they should he considered as auspicious until proven otherwise. V&xbs were in a class by themselves. She normally crystalline carcinogens in crudes (e.g. lima crude) may be concentrated during certain steps in wax processing. The 700 7. cut-point applied only to T hydrocarbons; other carcinogenic compounds that boil below 700 7. may be present, such as aromatic amines perhaps in shale oils, certain sulfur and oxygenated coo- Dr. Holt, in discussing the effect of dilution, said tests show that 65-69$ aixtures of decanted oil in non-carcinogenic oil have essentially the same potency as undiluted decanted oil, $0$ mixtures about 3/4 the original potency, 2.9$ aixtures 1/3 to 1/4 of the original potency. Ho data are available as yet on the potencies of blends containing less than 2^i> decanted oils. Kr, Tischer, in reply to an inquiry about crank-case drainings, said that he had no information as to their carcinogenicity but would suspect them because of the severe conditions that crank-case oils may undergo. Or. Trank said he had seen a statement that pipeline paint stay be carcinogenic. It was decided to hold another meeting of the Subcommittee after the Memphis aeeting and before the Detroit Meting, the tim and place to be determined by the Chairman. i.I. Dooley Secretary Mclver Woody Chairman API 04834 9* UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE CINCINNATI 19, OHIO j n"*0^, laeOEATORV or APPLIED PHYSIOLOGY _reo- ,,rua_ ry. 2r-Od, - ~ CABLE ADDRESS, KETLAB, CINCINNATI TELEPHONE, UNIVERSITY SERE Mr* D. V. Scroop, iae American Fetrcleum Institute, pO West 50th Street, "ev York City 20. .11/*' pear Mr. Stroop: l am sending you herewith an account of the financial status of the American Petroleum Institute project for the investigation of petroleum compounds as of January 1, 15^9- Very truly yours, ef Enc. E. R. Fortlager, Secretary to Dr. Kehoe API 04835 UNIVERSITY OP CINCINNATI LETTERING LABORATORY OF APPLIED PHYSIOLOGY ACCOUNT -OP TEE AMERICAN PETROLEUM INSTITUTE For the Fourth Quarter of 1948 (Based on Proportion of Time Actually Spent on Project) ' Robert A. Kehoe - Supervision Francis Heyroth - Chemical and Toxicological Asst. Karl Eitzmiller - Pathological Assistance yesley Horton - Chemical Assistance Sylvan Witherup - fl R j. F. Treon - If If Dan Duvall Tom Gahegan Ruth T*lger - Technical Assistance -n n - It R ECUS EXPENSE Traveling Expense - November and December Chicago to Cinti. (Dr. Wesley Horton) 1J.61 Cinti. to Chicago " " " 108.03 Philadelphia to N.Y. " " " 22.37 Cinti. to Chicago (Dr. R. A. Keboe ) 52.50 Cinti. to Chicago (Dr. F. F. Heyroth) 41.88 proportion of Secretarial, Library, Janitors, Wash Boys, Draftsman, Shipping Clerks, Animal Caretakers, Histopathological Preparation ............................ .... Proportion of Heat, Gas, Electricity, Steam, Telephone, Maintenance, Pensions, Annuities etc d ....................... 34.60 41.57 138.40 420.00 60.00 31.11 44.44 16.28 3-52 789.92 242.39 / 238.55 593*00 1663.86 Balance Remaining for Work in 1948 at end of Third Quarter 1948 ............................ $24,261.84 Expend!tures 4th Quarter 1948 ....................... . 1,663-86 Balance Remaining for Work in 1949 .... 22,597.98 API 04836 VS ^ _ "TV\- E_ j c ------------ i, 1**> pp. v. a. LaLande, Jr., Pviuglmii S^It --rmTacturlag Co. nr. C. 0. iisnfce, . I. Du Pent d BoKours and Caapany jr. D. A IyvJLa, Hartmat Coetpenj of Jnsrloa It*. Basil tarsfiold, Rtynolds Metals Company gr. i. |u Astaaa, Mwml on Product* ctapeny Cr * ft* awarioan Patroltm Institute friar w MOOtmt of All floorIda* fagtBi , irt itagUsd on t J* * 1b All rSOSip staat of tbs IB MOOVdOBtO* vlth 7 mmtriimkkmt if tit ontlnuad for a sroood . ffSBt 1ft AM. ?D1* m of t* library vlthont to ttHVt U IMP sstltatad 1b 19*6} Oariaa tr tmm All klaAa* I trust bs sura tbo rortc on Bdudad md tb tltuto fvbie& iA to tho ram to b* ptovlda t$s SArviOM 1ratal Tsrfc, sad also (OIFST tbttt In tbs OOAt Of MppllAA Of Approval, tat taa A dAOldAd AUldSlBfrilj IB literature M > tbs oiwlai tta Wfr MMdtt IB inotds t&QB tis fmds MI f Slottd tat not md* Ibo. 4 $' /fee. KbiH'^'MS/i. B: r API 04837 * t*inuo C--pony of Aasrlea t> Sbaro of ixpease os ZteMsed Belaaee Psnalaiaa froo 1947 Appropriation - 1000.00 Receipts 1948 ................................................. 3000.00 pffiamm Petxdeun Xastltute SfciM of Expense as Z Unload Balaaeo fr-- 1947 Appropriation.........................2300.00 Rooolpta 1948 ..................................................... .... 2300.00 Balaaeo for 1949 Appropriation X. duPont do lenours and Conpiay Stare of Xxpease aa It--1sod . Boeolpto 1948 ..................... Ivanla Balt Xfg. Co--oaj Stem of i--onoo......................... Balaaeo duo fr-- 1947 ................. Boeolpto 1948 ................................. Balaaeo duo -- 1941 Apprsprlatl 2000.00 4000.00 4000.00 4000.00 2300.00 5000.00 2300.00 5000. 2000.00 2000.00 Ids Metals Oo--on]r Share of in --i as Ztonlsod stars Balaaeo duo fr-- 1947 apprsprlatl-- .... 4000.00 Boeolpto 1948 ......................................................... 4000.00 4000.00 4ivtrsal Oil Produets Co--say Stare of iTpsntt as Zt--lsed above............................................. Boeolpto 1948 .. ..................................................... talaaoo duo -- 1948 Appropriation......................................... 1000.00 qqqq.qq 1000.00 API 04838 )y urxvaftsxrr op cxbczxbatx KSTT&HXIO LABORATORY OF ATFLUX) PHT5IOLOOI accoost or the floorii pboject 1943 (Baa*4 os Proportion of Tine Actually Spout on Project) ,aMrt A. Echo# ILfteli Heyrotta JS*rd Largent Sob Cholak Dutra Tljori* Christion So Laslck (i*0 Blocks ton Srlss Pox So Broorlag lollor >ls Bloekston file nRvot~h Son Michols Jtfes coppol M. Roldan |frd Signon - Supervision (Oonorol) - Supervision * Prlnelpol Investigator - Supervisor of Analytical Work - Pathological Assistance - Kevlev of Literature - Ievlev of Literature - Analytical Asst, and Experimental Sub - Analytical Assistance nous mrasfc food and Expenses incurred in tbs Collection of Bangles by taperlasntal Subject............................. .... . . laboratory Supplies rtlan of Secretarial, Library, Wash Boys, Shipping Clarks, Draftsman ate............................................................ mporUn of Beat, Sas,telsphnae, Peetags, liestrialty. Pensions, Annuitiee, Postage, aiatsasass ate .... TOTAL Receipts 1948 ......................................... . 16,500.00 Balance due oa 1948 appropriation 5,000.00 Total Receipt# Toward proeeeutlon of Prograa................................. . 19*300.00 Total Expenditures 1943 ..................... 18,323.21 Science B--Inlng for 1949 .... 676.79 3.53 59.56 1779.72 239.94 22.67 1300.00 36.10 1312.03 933.93 606.06 464.25 131.10 49.00 426.67 97.02 415.08 205.30 3637-36 2037.00 2923.54 2177.88 3047.43 18,323.21 API 04839 Copy from D. V. Stroop for Information of Members and Associates of API Medical Advisory Committee. 3-14-1+9 March 8, 194-9 Dr. W. A. LaLande, Jr., Pennsylvania Salt Manufacturing Co. Mr. C. 0. Henke, E. I. du Pont de Nemours and Co. Dr. D. A. Irwin, Aluminum Company of America Mr. Basil Horsfield, Reynolds Metals Co. Mr. E. M. Matson, Universal Oil Products Co. Mr. D. V. Stroop, American Petroleum Institute . Gentlemen: Prior to our meeting on March 30 > I send herewith the summarized account of all expenditures made in connection with the work on fluorides for the year 1948. All receipts have been included and are itemized on the second sheet of the account. In accordance with my best Judgment, I have assumed that the contribution of the American Petroleum Institute (which has been continued for a second year) should be added to the sum to be spent in 1948. This has made it possible to provide the services of the library without curtailing the experimental work, and also to absorb the increase in the cost of experimentation (over that estimated in 1946) represented in necessary increases in the salaries of personnel and increases in the cost of supplies of all kinds. I trust that this will meet general approval, but the matter should be discussed at the meeting and a policy decided upon for the future. The cost of the library work will be decreased considerably in 1949, since the intensive work of surveying prior literature has been done. This will provide additional funds for the experimental work proper. It was necessary to curtail the work somewhat in the last quarter of 1948, so as not to make in roads upon the funds available for subsequent years. Sincerely yours, RAK ef Dictated but not read. // Robert A. Kehoe Robert A. Kehoe, M.D. API 04841 UNIVERSITY OF CINCINNATI KETTERING LABORATORY OF APPLIED PHYSIOLOGY ACCOUNT OF THE FLUORINE PROJECT . 1948 SALARIES (Based on Proportion of Tine Actually ' Spent on Project) Robert A. ICehoe Francis Heyroth Edvard Largent Jacob Cholak Frank Dutra Marjorie Christian John Lesick Elmo Blackston Charles Fox Leo Broering Jim Zoller Morris Blackston Jim Roth Anton Michels John Cappel Wm. Holden Howard Sigmon Supervision (General) $ Supervision Principal Investigator Supervisor of Analytical Work Pathological Assistance Reviev of Literature Review of Literature Analytical Asst, and Experimental. Sub. Analytical Assistance 8.33 59.56 1, 779-72 239.94 22.67 1, 800.00 36.10 1, 312.08 983.98 606.06 464.25 131.10 49.00 426.67 97.02 415.08 205.80 i637.36 MISCELLANEOUS EXPENSE Food and Expenses Incurred in the Collection of Samples by Experimental Subject ........................................................ Laboratory Supplies ............... ,................................ ,...................... Proportion of Secretarial, Library, Waeh Boys, Shipping Clerks, Draftsman, etc........................................................... Proportion of Heat, Gas, Telephone, Postage, Electricity, Pensions, Annuities, Postage, Maintenance, etc............. 2 037.00 2 923.54 2 177.88 3 047.43 TOTAL .............................................. 18 823.21 Receipts 1948 .............................................. $ 16,500.00 Balance due on 1948 Appropriation........ 3 .000.00 Total Receipts Toward Prosecution of Program .............................................. 19,500.00 Total Expenditures 1948 ........................... 18,823.21 Balance Remaining for 1949 ..................... 676.79 API 04842 MISUSES SPBCOHMUTEB 01 ClBCIHQgEHICITr March II. ms A seating of the Subcommittee on Carcinogenicity was convened at 10 A,.M., Friday, Karch 11th, 19^9, at 1$ Beet 51t Street, Few fork City. * ytfHERS FRESBTTi .1. fioag J.F. Holt .B. Levie M.H. levquist Mclver Foody H.S. Bonsib A.E. Dooley H.O.M. Tlscher H.F. Lankelma X.S. MacXensle QUESTS! A.V, Horton J.J. PhalrD.7. Stroop University of Cincinnati University of Cincinnati American Petroleum Institute fOfAL IF AIOTDIIC* - 13 MOTHERS 1BSEBT: L.I. Curtis f.M. Frank *.J. Felly C.A. Swan L.C. Beard AeJi-foewingt ir% H.H. Zuidema Dr. J.J. Fhair, Professor of Preventive Medicine, University of Cincinnati, was introduced. Minutes of the seeting of February 1st were approved. Dr. Horton reported that hit laboratory equipment is being assembled and his new facilities will be available about May 1st. In the meantime, he is visiting refineries and studying the various types of catalytic cracking units and their operation for the purpose of making the proper choice of samples. He stated that Shell had offered to cooperate in a pilot-plant operation to yield sasples which could be used to determine effects of variables, such as natures of API 04843 r . feed., temperature, rate of through-put, etc. He thought this approach to the problem might yield valuable data and samples that could be studied concurrently yith: (a) the search for an analytical tool, and (b) the animal testing of the 21st of materials recommended by the technical advisors to the Subcommittee in its January 31st, 19^9 meeting. Sr. Holt said that before deciding on the inclusion of the pilot plant approach, I tbs technical advisors should be consulted. Mr. Tischer felt that the pilot plant phase, while of scientific interest, might Bet answer the practical problems because of the great variations in feed stocks. Be feared that it might bog down the animal testing program and believed that it gbould receive a low priority until answers to the prs^tlcal phases of the problem bad been obtained. Mr. Bonslb agreed with Mr. JTischer's comments because of tbs jsatijr variations in feedstocks. '-ri. 4-^" Sr. Horton replied that refinery sasples would present these same variations and cosplications. It waa his plan to get the pilot plant runs on three selected feeds containing; 0, 30 and 60 per cent aromatics respectively. Mr. lankelma, while agreeing with Mr. Vischer, believed that sooner or later this phase would have to be a part of the study. Mr, Mackenzie thought that the nature of the charge stock was of minor importance compared to operating conditions; and that one run on a paraffinic stock should settle the question of the effects of time and temperature. Mr. Jischer said that his company had tested Mnples from different feed stocks and had concluded that fluid-catalytic cracking operations presented a carcino genicity problea. He recommended that the analytical study be given priority. Dr.- Horton urged that Shell's offer be considered because of the time required jto prepare the samples. He pointed out that oil 3^32 was being fractionated and that the frMtions would be tested on animals, in attenpt was being made to Isolate the carcinogens in hope of obtaining an analytical tool. Zt was the unanimous opinion of the Subcommittee that the analytical work on oil 3632 should go ahead. Dr. Horton said that this analytical work may be long and complex; he thought that the other phases should not be delayed. Dr. Holt divided the problea into four aspects: ' 1. Does a problem exlstf That was the question two or three years ago. Work to date indicates that there is a potential problem. I ! I -2API 04844 )* 2. Where does it exist; in what operations, oils, fractions, materials, etc. is there a hazard that requires protective measures? 3. Can these operations he changed to control the problem? 4. Development of a technique to eliminate animal testing* If a study of the processes were added, there would not he sufficient facilities available. He recommended that a list he made of all samples to he studied and that the Subcommittee then schedule them for priority in testing* Nr. ?ischer said that such a list of samples had been approved at the last meeting of the technical advisors and that Dr. Horton was to collect the samples listed and report to the Subcommittee. The proposed schedule of testing them and the analytical work on oil 3632 should he continued concurrently. His personal view was that samples obtained from a pilot plant run should he placed way down on the list. Dr. Horton estimated that when the new facilities are available about June 1st, 4,500 mice could be handled which would mean that 150 to 200 samples could be undergoing tests at one time. Dr. Hoag Bald that the first oils to study were those to which exposures are now occurring, in order to determine control measures. Dr. Hevquist was of the opinion that, while it was very important to test various oils in order to determine which ones present a hazard and call for protective measures; nevertheless, the analytical work should be continued, ilso, because of the limited number of samples that can be tested, the pilot plant studies should get under way. Dr. Voody said that this question would be up for discussion again at the ipril meeting in Detroit and that, in the meantime. Dr. Horton would discuss it with Dr. Xehoe and Dr. Heyroth. Dr. Holt proposed that Dr. Horton prepare a summary showing the total number of samples that may be desirable to study at Cincinnati between July 1949 and July 1951 and the order in which they should be studied. Dr. Horton agreed to submit such a list by Nay 15th. Seportlng on the Vatlonal Cancer Conference recently held in Memphis, Dr. Hoag Bald that Dr. Holt and Mr. Tischer were to be congratulated on their handling of the subject. Dr. Hevquist added that tEe cancer question was now an open story. He also commended Dr. Holt for his presentation; no hysteria was aroused and what was said was not embarrassing. Dr. Voody submitted a revision of our confidential memorandum of ipril 2nd, 1948 proposed by Dr. Curtis. On page 3, the third sentence in the last paragraph was changed to read as follows: -3- _ . _ **1 )1 "Experiments in the laboratory have shown that certain of the high-boiling materials from these newer processes cause the de velopment of tumors and cancers on mice." and the foot-note was omitted. Dr. Phair said that he planned to get acquainted with the medical directors of the various companies to see what medical records are available and to determine whether epidemiological techniques could be applied to advantage. The long "incubation period" was one of the factors that complicated the problem. The adoption of control measures might be better than attempts to eliminate the hazard. In r* eponse to a question from Dr. Eewqulst, Dr. Phair eald that a cancer registry for the petroleum Industry was an inherent objective of the control program. He added that he had doubts as to the successful enforcement of laws requiring the reporting of cancer cases, as has been proposed by some investigators. The next meeting of the Subcommittee will be held in Detroit April let, 19**9. A.I# Dooley Secretary Hclver Woody Chairman API 04846 V 1 PERSONAL AMD COHFIDENTIAL MEMORANDUM FOR IHrORMATION OF , W. R. BOYD, JR.. PRESIDENT, AMERICAS PETROLEUM INSTITUTE ?/' ' It has "been stated that petroleum products cause cancer. To the informed, this sounds like a very serious matter and in the interest of undergt&n&ine ani proper evaluation of such a statement, the following facts are presented. Very little is accurately knovn about the causes of cancer. Causative jgents which have been cited in the Technical Literature include soot, coal and gas tar, asphalt, crude oil, unrefined paraffin wax, certain chemicals, pitch, grsenlc compounds, nickel compounds, chromium compounds, and sunlight. It has gj.so been recently proposed that cosmic rays may contribute to cancer. There is also medical evidence, although controversial, that mechanical irritations such as injuries caused by blows may be contributlve. Other possible producing causes vbich have been cited are Internal secretions produced by the body Itself. The number of cases of cancer reported to have been caused by contact vlth industrial materials is exceedingly small as compared to those which arise from unknown causes. Vlth regard to the petroleum Industry, fey cases of cancer have been reported. Reference is made to the Government Bulletin No. 284 of the U. S. Public Health Service from which the' follovlng abstract is taken: Disabling morbidity and mortality from cancer among male employees of oil refining company with reference to age, site and duration. V. M. Gafafer and Rosedith Sitgreaves. Public Health Reports 55: 1517 (Aug. 23) 1940. "The authors studied the records of the members of a sick benefit plan connected with an oil refining company. The study covers a period of 6 years, from 1933 to 1938, during which there "was approximately' 60,000 years of membership for the male employees. There were 70 cases of cancer, 46 of vhieh ended in death. The eases vhlch did not end in death terminated in recovery or In sufficient improvement for return to work. The 46 deaths yield an average annual death rate of 0.78 per thousand. The population exposed represents an age distribution ranging approximately from 15 to 69 years. The calculated crude death rate from cancer for vhite males frem 15 to 69 years of sge throughout the entire United States for the years 1933 to 1937 is 0.96 per thousand, while the expsrlesce of the industrial department of a large life Insurance company for 193? gives a rate of 0.86. Previous studies have Indicated that certain types of mineral oils possess carcinogenic activity; the present experience is therefore not unfavorable The above quotation shows that up to 1938> mortality per thousand bweons due to cancan from all cause a in the petrbleum industry, as represented ty this group, was less than In the United States aa a whole'. -2- 1 Turning now to the reports in the medical literature that petroleum oducte cause cancer, we find the following: Clinical and experimental data show a great difference in the carcinogenic (cancer causing) properties of semi-refined and refined oils and paraffin waxes, depending, in part, upon the chemical composition of the raw materials and, in part, upon the method of fractionation, distillation and refining (1). According to Schwartz (2) oils derived from shales are more carcinogenic than petroleum oils, while pure medicinal petroleum oils are non-carcinogenic. Scott and others (3) (4) have reported the occurrence of a signifi cant incidence of skin cancer among workers in Scottish shale oil refineries. He noted that in these workers malignancy was preceded by the presence of warty growths, and that the change of these growths to cancer could occur long after withdrawal from exposure. The so-called "mule spinner's cancer," which generally involves the scrotum, occurring among textile workers in the cotton textile industry in England, is the commonest cancer associated with oils. In the process of operating the machine (mule) that makes the yarn, the mule spinners have skin contact with the oil that is used to lubricate the spindles. A study of the problem by a committee appointed by the British Government (5) indicated that the high incidence of scrotal cancer among mule spinners was a result of long contact with lubricants of the type used. Altogether 3^5 scrotal cancers causing death among mule spinners were reported in England from 1911 to 1935 (6). Only six reports of mule spinner's cancer are on record in the U.S.A., and only two of those were positively contracted as a result of exposure in the United States (1). The difference in the origin of lubricants is presumed to account for the variation in incidence of the disease. Individuals employed in filter press operations in which paraffin wax is separated from certain petroleum oils have been reported by Heller and others (7) (1) to develop skin cancer. Wood (8) states that pure paraffin wax is not productive of cancer and Schwartz (2) reports that workers with refined white paraffin do not suffer from deraatoBes, epitheliomas (skin cancers), or papillomas (wart-like growths) which affect those who handle crude paraffin wax. Schwartz (2) has reported the presence of epitheliomas in oil field workers in California. Individuals who developed cancer tram, exposure to oil or paraffin wax have gonerally been exposed to the material for a period of from 10 to 50 years (1). The mortality, based on certain English statistics, from paraffin wax cancer was 13 per cent, and frem mule spinner's cancer 51 per cent of those having cancers (1). Approximately k3 cases of paraffin cancer have been reported in Germany and Austria; a few cases of oil cancer in France; about 150 cases of paraffin wax cancer and over 1,500 cases of oil cancer have been reported in Great Britain; in the United States approximately 50 paraffin wax and 12 oil cancers have been reported (1). API 04848 * * -3- % from this information'it is clear that fev cases have been reported in this country compared to the number of cases that have been reported In England. This appears to be due to the fact that the mineral oils that have been used in this country vere much less carcinogenic than certain oils from Bhale used in England; for example, it is stated (1), on the basis of experimental studies, that refined American oils vere only one-twelfth as potent in the production of cancer as oil from shale and that a worker in contact with Pennsylvania oil is only one-fiftieth as likely to develop skin cancer as a worker exposed to oil from shale. Experimental studies on mice with various fractions of crude shale oil (9) shoved these materials to be carcinogenic; while experimental studies on mice by Tvort and Ing (10) on various brands of purified liquid paraffin oils showed these products to be non-carcinogenlc. Davis states (11) that animal experimental studies on slack wax and pressed distillate have failed to cause cancer of the skin. Extensive experimental studies by Tvort and associates (12) demonstrated the carcinogenic properties and potency of certain crude and refined mineral oils. Epitheliomas of the skin caused by occupational contact with mineral oil and paraffin are included among the compensable diseases in Argentina, Australia (West Australia and Queensland), Belgium, Cuba, Great Britain, Ireland, Rumania, Venezuela, Germany, Russia and Mexico and in the U.S.A., the states of California, Connecticut, District of Columbia, Illinois, Indiana, Massachusetts, Missouri, New York, North Dakota, North Carolina, Wisconsin, Ohio, Pennsylvania, Rhode Island and Washington (1). At first glance, the above evidence may seem formidable, but let us examine the matter a little more closely. First, those hydrocarbons which cause skin cancers are relatively high boiling (above 700F.). Such compounds, therefore, are not found in gasoline, kerosene, and home heating oils. Lubricating oils generally are treated with sulphuric acid or other agents vhich will remove a substantial portion of any cancer-causing materials that aay be present. American crude oils, according to the record, contain less cancer-causing materials than oils from shale vhich vere largely responsible for the initial unfavorable shoving experienced by the British textile industry in the use of lubricating oils from shale. The petroleum industry has been studying the possibility that products from the never processes of refining are more carcinogenic than those used before the war. To date, there is no evidence of cancer among employees that can be attributed to exposure to those products. Experiments in the laboratory have shown that certain of the high-boiling materials from these sever processes cause the development of tumors and cancers on mice. Products derived from certain sources and processes that have been employed for many fears have shown a similar tendency to some degree. Extensive vork is in progress in biological and analytical laboratories with the objective of developing a clearer understanding and a better knowledge of the compounds that possess carcinogenic activity and the process features that aay influence uch activity. T The question naturally arises as to what protection can he afforded, jjje most important protectire measure is personal cleanliness, and this applies pot only to workers in the petroleum Industry, hut also to those who use -atroleum products. Oil-impermeable protective outer garments, clean under clothing, and dally showers at the end of work are recommended as well as -eriodic medical examinations. In other words, with adequate medical supervision the pursuit of hahlts of cleanliness, the chances of industrial cancer from petroleum are remote. This confidential memorandum summarizes the primary sources of information known to members of the Institute's Medical Advisory Committee vhich has recanmended its transmittal to the President for such use as he may deem necessary or desirable. ' Submitted by: M. N. Newquist, M.D. Chairman, Medical Advisory Committee. Amended 3-H-U9 API 04850 > -5- REFERENCES Hueper, W.C.: Occupational Tumors and Allied Diseasos, Charles C. Thomas, Springfield, 111., (19L2). 2. Schwartz, L., Tulipan, L. and S. M. Peck: Occupational Diseases of the Skin, Lea and Fohiger, Philadelphia (19^7)> 3. Scott, A.: Cancers in Mineral Oil Refineries, Report of the International Conference on Cancer, London, July, 1928, held under the Auspices of the British Empire Cancer Campaign, Bristol, John Wright and Sons, 1928, p. 27 J. Ind. Hyg. and Toxicol. Ah. 11:28, 1929. VJI h. Kennaway, E. L.: The Anatomical Distribution of the Occupational Cancers. J. Ind. Hyg. and Toxicol. 7:69, 1925 5. Report of Departmental Committee appointed to consider evidence as to the Occurrence of Epitheliomatous Ulceration among Mule Spinners. London, H.M. Stationery Office, 1926. Cited in Heller, I.: Occupational Cancer, J. Ind. Hyg. 12:169-197, 1930. 6. Henry, S. A.: The Study of Fatal Cases of Cancer of the Scrotum from 1911 1935 in relation to Occupation, with Special Reference to Chimney Sweeping and Cotton Mule Spinning, Am. J. Cancer, 31:28, 1937* 7. Heller, I.: Occupational Cancers J. Ind. Hyg. 12:169-197, 1930. 8. i9. Wood, H. B.: Paraffin not Productive of Cancer, Jour. Cancer Research, 13:97, 1929. Leitch, A.: Brit. Med. J., 2:110k, 1922. : , .10. Twort, C.C. and H. R. Ing: Lancet, 1:752, 1928, Ztach, f. Krebsforsch, 27 308 1928 11. Davis, B. F., J.A.M.A., 62:1716, 191**. 12. Twort, C. C. and J. M. Twort: Lancet, 1:1331, 1930; 1:286, 193**; 2:1226, 1935. j. Hyg, 29:373, 1930, Ztach. f. Krebsforsch, 32: **91, 1930, J. Ind. Hyg. 13:1931, Am. J. Cancer 17:293, 1933, Oil and Color Trades Journal, Oct 22, 1937; Twort, C. C. and J. D. Fulton, J. Path, and Bact. 32:lk9, 1929, Ztsch f. Krebsforsch, 35:5*0, 1932; Twort, C. C. and R. Lyth, J. Hyg., 33:**6L, 1933; Twort, C. C. and H. R. Ing., Lancet 1:752, 1928, Ztsch, f. Krebsforach, 27:308, 1928. API 04851 MEMBERS PBESEBT Marshall Clinton L.X. Curtis T.M. Trank J.F. Holt / T.J. Telly M.H. Rewquist Mclver Voody 71 SITORS V.C. Baird T.T. Boys Xleffer Darls A.X. Hoag X.X. Linder X.F. Lnengo H. Clinton Page B.B. Rosts WESTS S.J.X. laid R.D. Bent ' = J.V. Saaaond BJL. Iehos~; \<V.L. Siapsen J.B. Stackers H.O.S. vaaRaalte Idl.IMarriok . Minutes of Meeting April 1, 1W Book-Cadillac Hotel Detroit, Michigan ASSOCIATES FBISETT Y' L.C. Beard, Jr. B.S. Sonsih A.X. Dooley H.O.M. Tiseher * HJP. Lankelaa X.G. Mackemie/ H.H. Zuidena-^ X.V. Ideas R.C. Cole X.J. Oothard B.M. landon T.M. Vetkins Institute of Petroleua, London Atlantic Refining Coapany, Philadelphia Enable Oil Coapany, Houston University of Cincinnati Detroit Institute of Cancer Research Fore Oil Coapany, Chicago / Shell Oil Coapany, Curacao, Xeth. Ant ill. Bxe Texas Company, lew York D.7. Stroop - API yPTBTBS ^JHggJIT VR. Leris C .A. Swsn TOTAL n ATTXXDAXCX - 36 ^PX 04852 * Hew members of the Subcommittee and. guests were Introduced* Minutes of the three previous meetings, November 11th, 1948, February 1st, and March 11th, 1W were approved after a change was made on Page 3, Line 9 f the March 11th, 1949 minutes by substituting the word "suggested" for "approved". Dr.. Eehoe stated that of the $40,000. capital funds provided by the jpl, $30,478. had been applied to building costs and $8,264, had been put into special equipment, leaving a balance of $1,258. to provide additional equipment as needed. Of the API grant for current expenditure, there remained a balance of $22,598* as of December 31t, 1948, of which about $14,660. would be used during tjje first six months of thiB year, giving a balance of some $7,000. as of July 1st, 191*9. Current expenses from July 1st, 1949 to June 30th, 1950 were estimated at $122,600., of which about 2$i would be covered by from payments from individual companies for testing their samples, leaving some $90,000. to $100,000. to be provided by the API. Thanhs to the API grant for capital expenditures, which came in the nick 0f tin* facilities would be available by July 1st for a colony of 10,000 mice which vould permit simultaneous studies on 175 to 200 samples. The API would have first claim on these facilities; but after that, samples submitted by any Individual company would be accepted for testing provided that they would not interfere with the API schedule. In addition to Dr. Eehoe, Dr. Heyroth and Dr. Dutra, 11 other persons would be required. Of these, Dr. A. Wesley Horton was already engaged in securing the necessary refinery and chemical data. Dr. J.J. Phair would start work on the eoidemiological phases of the problem after July 1st. Other personnel would in clude: a chemist to assist Dr. Horton; a record clerk to maintain complete records on all the mice; three technicians to do the actual application of samples to the nice; one technician to prepare tissue sections for the pathologist; and two animal caretakers. A principal investigator was yet to be selected. This investigator would have to be an excellent pathologist, as well as a good administrator because he would be responsible for: a. Supervising application of the samples to the mice. b. Establishing standard criteria for. 1. Determining existence of tumors. 2. Differentiating between tumors and dermatitis. 3. Establishing whether tumors are benign or malignant. Dr. Hewouist asked about the method of selecting samples for testing. Dr. Eehoe replied that this would be the duty of Dr. Horton, working with the Subcommittee and its technical advisors. Hr. Beard asked \diether results of tests of samples submitted by indi vidual companies would be available to-the API. Dr. Eehoe said they would be available only with the consent of the particular company and then only on a confidential basis. Mr. Fischer thought the proposed program was well organized but wondered whether the personnel proposed by Dr. Eehoe vould be sufficient to carry on all the necessary work. -2- API 04853 I Dr. Sewoulst thought experiments on primates should he started at an ggxly date bec&use of the time required to get results. Dr. Kehoe replied that javestigators of carcinogenicity of petroleum and its products had two objectives: first, to find a tool for determining potencies; and second, to determine whether suits of animal tests are applicable to man. The first phase required a group 0f stable, non-variable animals, such as the highly inbred C-H mouse strain, jjjis stability and lack of variability between the individual animals was not found in primates. As to the Becond phase, there was no definite evidence as yet that the results obtained in mice were applicable to man. It might be necessary to use other animals to establish the relationship. In that case, the laboratory had other animals available and, while it was not anticipated that monkeys would he used at first, this might be done later. Human experiments could not be set ^ until a good deal more information and knowledge was available, and even then only carried out under his personal responsibility. Dr. Slm-DBon pointed out that since susceptibility varies between in dividuals and since humanB are not homogeneous, any tests on humans would have to be done with statistically significant groups (many thousands) and that there fore, as far as establishing potencies is concerned, this approach would not be practical. Furthermore, a carcinogen too low in amount to produce a local reaction, might be absorbed and produce a carcinoma elsewhere in the body. * Col. S.J.M. Auld. Chairman of the Research Group of the Institute of Petroleum, London, described the carcinogenicity problem in England and asked for an exchange of information between the API and the Institute of Petroleum. Mule spinner's cancer was still a problem in England, 20 deaths having occurred in 19^7. After the earlier work in the nineteen twenties, there had been a lull but the subject was brought up again after the war, largely due to the action of the trade unions. The University of Birmingham had started research work and had found that extracts from solvent refining operations produced Bkin conditions which were "core than a mere dermatitis". More recently suspicion had been cast on some cutting oils and some motor oils from Scotland (not shale oils). The publicity attending the use of mineral oils as cooking oils during the war caused the Government to enter the picture with the result that the Medical Research Council (a government group) and the Institute of Petroleum (which succeeded the Petroleum Board) were now cooperating as a joint committee. Under the direction of Messrs. Squiers, Cook, Ferguson, Woodhouse, Irvine and Auld, a long-range t research study has been started, beginning with an investigation of these three crudes: Venezuelan crude - naphthenic type Middle East crude - Kuwait Mid-Continent crude (USA) - of importance in lubricants. A certain amount of supoort was given still to the unfortunate formula by Twort regarding refractivity; but later work indicated that the higher the aromaticity, the higher the carcinogenicity. The industry in England had made white oils available but there has been little demand for them as yet. There was no evidence that solvent refined oils are carcinogenic. Shale oils were going out of the picture. Some preliminary idea on potency of oils might possibly be had by determining their effects on plants. It appeared that the fractions which are the most active plant poisons are those that seem to possess the highest carcino genic potency and that perhaps by fractionating the oils and testing these S>~ API 04854 )* fractions on plants tone Index of carcinogenicity night he developed. Dr. Woody read a letter fron the American Cancer Society requesting API to report the anount of money it was spending on cancer research, so the Society could include it in their report of grante-in-aid for cancer research, lb-. Stroop was asked to obtain information on how this data would he used hy the j^erican Cancer Society. Action hy the Subcommittee - It was voted to recommend to the Medical j^dlvsory Committee thatl 1 - Information on carcinogenicity he exchanged with the Institute of Petroleum. 2 - The budget for the year beginning July 1st, 1949 for the program at Kettering Laboratory he in creased to $100,000.00 ! A.Z. Dooley Secretary Mclver Woody Chairman -4API 04855 1 w *wC -- l c "+'l AMERICAS PETROLEUM INSTITUTE SUBCOMMITTEE OS CABCIBOQESICIfr MISPTBS Of ISTEHIM MEETISO Juna ?. 1949 An interim neeting of the Subcommittee on Carcinogenicity vas held on Priday, June 3rd, 1949, *t 15 Seet Slat 8treat. Sew Tork City. MEMBERS PRESENT ASSOCIATES PSESEST Marshall Clinton T.M. Prank A.E. Hoag J.P. Holt T.J. Sally M.S. Sevquist MeIvor Woody L.C Beard, Jr. H.P Lankelaa I.G Maeksntie B.M Shepardson (representing H.G.M. Plscher) H.H Zuidema CHESTS R.W. Paulk - Shell Oil Company A. Wesley Horton - University of Cincinnati ASUSS! D.V. Stroop - API TOTAL IS ATTENDANCE - 15 MEMBERS ABSENT ASSOCIATES ABSENT L.E. Curtis W.R. Leris C.A. Swan B.S. Bonsih AJE. Dooley H.G.M. Pischer Minutes of the meeting of March 11th were approved as issued. Mr. Stroop stated that the API prefers not to he included in the American Cancer Society's list of grants-in-aid for cancer research. Dr. Horton submitted a progress report. (Copy of the report is attached as Appendix A). Dr. Woody said the Pederal Security Administration has awarded over $450,000. in federal grants for cancer control and teaching activities. The API 04856 b* V r largest amount, $35*000* went to the Pennsylvania Department of Health, where Dr. Shilen, Director of the Division of Industrial Hygiene, has set up an occupational cancer control program with a physician and a nurse. At a later date, two engineers and a statistician will he assigned to the project. The attached forms (Appendix B) are being prepared in quantity for use in their surveys and are essentially identical with the form submitted to them by Dr. Hueper to insure uniform data from the various states participating in the Industrial cancer program, file oil industries located in the Philadelphia area are high on their agenda. Dr. Hoag and Dr. Bewqulst spoke briefly concerning articles on cancer they have written for the Secony-Vaeuum lews and Texaco Topics re spectively. It was agreed that other companies could well afford to follow their example. T.M. PHASE Secretary MeITER ROOD! Chairman 4 API 04857 afpudix a API PROJECT ON CARCINOGENICITY AT THE UNIVERSITY OF CINCINNATI The program at the Kettering Laboratory is roughly divided into three major phases. Of perhaps most immediate importance is the effort to pin point throughout the industry materials and operations which represent potential hazards from the cancer standpoint. The second phase, which will be prosecuted simultaneously with the first phase, will involve the concentration and isolation of the compounds re sponsible for the carcinogenic action of certain catalytically cracked oils which have already been tested biologically. From the physical and chemical properties of such concentrates, an effort will be made to develop an analytical tool which may then be applied to any refinery stream to determine its carcinogenicity without resorting to animal testing. The third major phase will be an epidemiological study of cancer in the petroleum industry. In carrying out the first phase in the program, as described above, a series of typical refinery samples will be tested on suitable laboratory animals to determine their relative carcinogenic potencies. It is expected that, in the course of the coming year ending June 1. 1950, testing of approximately 150 to 200 such samples will be started at the Kettering Laboratory. Thus an average of about 12 samples from each of the following processes will be studied: 1. Non-catalytic gas oil cracking 2. Viscosity breaking of residues and extracts 3. Naphtha reforming 4. Polyforming 5. Coking operations 6. Houdry catalytic cracking 7. Fluid catalytic cracking 6, Thermofor catalytic cracking 9. Cycloversion 10. Houdryflow cracking 11. Hydroforming 12. Slack waxes and aromatic extracts therefrom ]3, Solvent extracts from lube oils and heavy gas oils. API 04858 I> 2- - The potencies of the samples will be compared with those of coal tar and shale oil fractions on which clinical data is available from England. In considering the selection of samples from each of the processes listed, attention is at present being re stricted to those intermediates or products with a distilla tion end point above 650CF. On the basis of confidential information supplied to the Kettering Laboratory by each of the API member companies on such materials and the unit operations producing them, a sampling program is being organized which will cover the current range of variations in each process. Careful consideration is being given not only to the characteristics of the particular products which will be tested for carcinogenicity but to the feed stocks and the unit operating conditions as well. In this manner it will be possible to correlate the effect of the trends in available charge stocks and refining practices with the relative carcinogenic potencies of products formed. Thus, the results of the testing program now planned should permit prediction of potential hazards as unit operations change in the years to come. As yet, a list of the specific samples to be tested during the coming year has not been prepared since the necessary data from the individual companies is not complete. However, sufficient information is available to permit the selection of a small number of samples from thermal cracking of high boiling materials, both virgin gas oils and those previously subjected to catalytic cracking. In addition it is planned to request samples of high boiling oils from TCC units since to date no physiological testing of the heaviest products from these operations has been carried out. In reporting results of tests on future oil samples, a direct comparison with a solution of a known concentration of a standard carcinogenic hydrocarbon in a standard solvent will be made. Preliminary tests are being run with solu tions of methylcholanthrene in benzene, at concentrations from 0.01# t% 0.6#. Previous results have indicated that the tumor incidence curves for typical heavy catalytically 04859 API II -3- cracked oils may be compared nicely with the curves for such standard solutions. In further work the effect of the benzene solvent on the tumor incidence and the induction period in mice will be determined. Various non-volatile solvents, such as methylnaphthalene, are being considered for this purpose. However, it must be kept in mind that benzene solutions of methylcholanthrene have been employed as standards for many years in studies by English scientists. Their use may therefore facilitate the interpretation of our laboratory results in terms of practical hazards to exposed workers. 1 I June 3, 1949. /7 s. k, Wesley Horton API 04860 + OCCUPATIONAL CANCER R3C0RD 1, Noma Residence 3. State: 2. riaca of Death: City: City: Uospltd: Street: 4. Soclel Security No. 7. Data of Birth: 5. Sex Age 8. Tears: M03. Days: _ 6. Color or Race: 9. Date of Death: 10. Occupation: 12. Cause of Death: 11. 13. Industry * Business: lietbod of Diagnosis Clinical; Biopsy: Autopsy: Other: .14. Nars of Physician: 15. Strset: 16. City: 17. Clinical Diagnosis: 0. Date of First Symptoms; 18. Pathologic Diagnosis: 19. Primary Site: 21. Date of First Visit to Physician: 22. Date of First Diagnosis: 24. History of Other Illnesses of Site Affected: 23. Stage of Disease et First Diagnosis: 25. History of Injury to Site Affected: s' . 86. Tryogura: Hare vou erer tetndled or worked war any of the following? If yes, give date lie. HAKE OF SUBSTANCE NAME OF BULGIER DATS LENGTH (T EXPOSIP.E j DESCRIBE TIPS OF EICP03URE AND ESTIMATE lERCHUT OF l 7.DRKKG TIME EXPOSED: 4 - ip p g y p ix b API 04861 I BIH-C-lb Occupational Cancer Reoord - Page 3 7. Occupational History: List Occupations In Chronological Order beginning vrlth last or present one. Detea TPOV TO j , TYPE OF 3CSIK2SS FAME OF aiPLOYER ' ADCRESS OF atPLOYHR l CR PRODUCT '.IAUK TITLE OF J<B THE OF VJORK PERFORMED 1 1 ! ___________________________ 1________________________ APPENDIX B 28. Are there any other Important mete rials to which you have boon ozposed? (Hobbies; Habits; tedicines; Cosmatlcs; Diets; Environment) 29. Additional Information Obtainable at: (List Physician; Leboratory; Hosplttl; Insurance Co; Plant Medical Department Clinic; Tumor Registry, etc.) Mama: Address: *>ane: Address: Name: Address: 30. Any other Information pertaining to Tumor (llultlpllclty, sites, etc.): kPX 04863 1* BIH-C-2 PLANT CANCER RECORD S. In operation since: 5. Number of worker^ employed: Vale: Tamale: Kbits: Colored: *. Ndne of plant official 6. Insurance Carrier: In plant: 4. Products Manufactured: In office: , -- --------------- ------------------------------------------- 7. Name of riant Physician . Carcinogenic hazards: 10. Operations Involved: 12. Sex of exposed workBrs: Hole: Female: 11. Number of vorkers exposed: a. Constant exposure b. Intermittent exposure e. Ooceslonel exposure 13. Race: White: Colored; Id. Duration of exposure: Number: Number: Number: 15. Rate of turnover In exposed group (a) Tears: Teara: Tears; '5. Cancers Observed In exposed group (s) 17. Canoers by sites: Total number: Period: IS iPfianiii b BIH-C-3 X. Mane of Company: RLAHT CANC3S RECORD Date: t. Location: 4. Products Manufactured: 9. Number of Workers: Total Tsmales Males White Colored 3. In Operation slnee: Office: Production: 6. Wane of Plant Manager: 8. Insurance Carrier: 7. Plant Physician: 9. Carcinogenic Hazards: 10. Operations Involved a b e d Number of Workers Total. White Colored Male Pearnle Exposure Constant Intermittent Ocoeslonel J f e b i J k 1 n 11. Type of Exposure Duration of teposure Inhalation Skin Indention Other Average Longest a b e d e f 8 h 1 J k 1 m n Cancers Observed Site Number Period 12. Sate of Labor Turnover: API 04864 UNIVERSITY OF CINCINNATI ' COLLEGE OP MEDICINE CINCINNATI IE. OHIO laboratory or arrued rhyriolosy June 2D, 1949 Mr. D. V. Stroop, The American Petroleum Institute, 50 Vest Street, New York City 20. Dear Mr. Strocp : I send you herewith an account of expenditures made during the first quarter of 1949 in pursuit of the A.?.I. project. From this information you will recognize that I was correct in my statement that the funds on. hand at the first of the year would he ample for the period ending June pO, 1949* I am sure you and your associates would he pleased to know that our building program is completed for all practical purposes, and that we are nov able to get things lined up so as to work in earnest. Within the next thirty days we shall he going forward on all of the fronts of cur projected work for A.P.I. Cordially yours, . RAK ef C .C .Dr. Mclver Voody - ' Robert A. Kehoe, m. D. 9 API 04865 }# UNIVERSITY OP CINCINNATI KETTERING LABORATORY OP APPLIED PHYSIOLOGY ACCOUNT OF THE AMERICAN PETROLEUM INSTITUTE FOR THE FIRST QUARTER OF 1949 ^ipjES (Based on Proportion of Time Actually Spent on Project) Franeis Heyroth Frank Dutra Joseph Treon A. Wesley Horton Dan Duvall Tom Gahegan Ruth Telger George N^dderman Wm. Poynter Chemical and Toxicological Asst. Pathological Assistance Chemical Assistance Chemical Assistance Technical Assistance n mn Rn nn ^TfgELLANEOUS EXPENSE Purchase of Animals Laboratory Suppliesj..................................................................... Traveling Expense .......................................................................... proportion of Secretarial, Library, Janitors, Wash Eoys, Draftsman, Shipping Clerks, Animal Care takers, Histopathological preparation etc . . . . proportion of Heat, Gas, Electricity, Steam, Gas, Telephone, Maintenance, Pensions, Annuities etc . 425.66 27.87 115.90 1800.OG 187.05 85.87 27.51 24.18 108-59 2802.43 63.00 945.89 .V 907.70 765.19/, ^ 6375.15 Balance Remaining at End of 1948 for vork in 1949 ....................................................... $22,597-98 Expenditures 1st Quarter 1949 ....................... 6,375*15 Balance Remaining for Work in 1949 .... 16,222.85 API 04866 Jam 30, 19*9 Hr. Bofeart k, Cefaoa lettering lotoratory of Applied ftyalolagy Callage of teiHnfm OalTarolty of fT--t--II Ciaolmtl 19, Ohio of Jam 20 aad tea n--t of oryoaflltiroo tela* mam to eoeflra year --rllor eotlaate teat tear* vlll to on oiyonAaA tolo-- la tee faoi at tea TMteralty of Claelaaatl oa Jtea y>, 19*9 of $7,658 or aero. Vo two talon tent ootlaato late eeaaldaratloa la tko yraiai atloa of tea oaalaaod ooatUnatl an 1 olanoI 7 tea JTaaldoatt and Bacretery aad ora aokaltted for I annojjtonai aad ayfrooal oa tekalf of tea Ontoralty of | Claelaaatl. #1 Qfcoa raaalyt of taa telly aoanutai ooylaa | ao ahall mmk yea a akaak la tea Ml of $*9,tt3. tery teoly ynaro. 91V id API 04867 American Petroleum Institute 90 WEST BOTH STREET NEW YORK 20. N. Y. June 30, 1949 Board of Directors University of Cincinnati Cincinnati 9, Ohio Gentleman: This communication Is authority to continue work and to expand the scope of Investigation of the toxicity and sods of action of certain petroleum products for the year ending Jons 30, 1950 according to the tens of the agreement dated January 8, 1946 and on the hula of a BftTlmnn budget for operating expenses of $98,825 which is conditioned upon an unexpended balance of $7,858 or sure remaining in the fund at the University of Cincinnati as of June 30, 1949. Upon receipt of your approval of the continuation and expansion of the project with this conditional ma-rlmnm budget we shall pay you the sum of $49,413, the balance of $49,412, less the unexpended balance of $7,858 or more, to be paid on January 1, 1950. It Is understood that any balance remaining In the fund on June 30, 1950 will be returned to the American Petroleum Institute, and that no excess over the amount of the budget Is to be obligated or spent without written authorisation. ary truly yours, API 04868 1 UNIVERSITY OF CINCINNATI COLLEGE OP MEDICINE CINCINNATI 19, OHIO 9 l>BORATORY OP APPLIED PHYSIOLOGY vUy ;, 9 CABLE ADDRESS, KETLAS. CINCINNATI TELEPHONE, UNIVERSITY SS8B Mr. D. 7. Strocp, Director, Department cf Safety, American Petroleum Institute, 5u nest Street, Mew York City . Dear Mr. Sttocp: Inis is to acknowledge your lette: of June pO with the enclosed copies, of the continuation agreement. The latter have been forwarded to the University, with our recommendation for their approval, and in due course the two executed copies requested will be returned to you. _ Sincerely yours, Hooert Eenoe, M. I>. RAH ef C .C .: Dr. S * Hoag Mr. Lacey Walker Dr. Mclver Woody API 04869 a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE CINCINNATI 18, OHIO `-A-O^ATONV OF AFFUED FHT.IOLOOV JUly ^ 1949 CABLE ADDREEIi KETLAE. CINCINNATI TELEPHONE) UNlVtaaiTV lltl Mr. D. V. Stroop, Director, Department of Safety, American Petroleum Institute, 5u Vest 50th Street, New York City 20. Dear Mr. Stroop: In accordance with Dr. Kehoe*s letter of July 6 I am forwarding to you herewith two executed copies of the letter of June JO, extending the agreement between American Petroleum Institute and the University of Cincinnati to June JO, 1950. Very truly yours, ef C .C Dr. A. E. Hoag Mr. Lacey Walker i Dr. Mclver Woody Enc. E. ./portlagSecretary to TVr . TCehne API 04870 ^riONT OF INDUJTIIAL Hyoiini HARVARD UNIVERSITY SCHOOL OF PUBLIC HEALTH July 12, 19li9 Mr. D. V. Stroop American Petroleum Institute 50 Test 50th Street. New York City Dear Mr. Stroop: Referring to my request that you pay the bill for killing the type of the Cutting Oil Review, we' can take this out of our budget and got a refund later,'as you suggest. If you wish to do so, please send copies of this4letter, (extras are enclosed) to Dr. Hoag and his committee mashers, advise me accordingly, and we'll call the matter closed. > r,\ . '%! Mr. Kxiste? Mas beea^ill-amd that is why the paper was not revised as agreed, pea*^,, It.will*be; dene .presently, y - . ' ,--*,44*- * siaeerely yours, PDtsl Ene. Id 1 <, -I$*&**. He-, t Ajrv IhiUp . 'v. '+ *** ' w *V -f -e * . f _ |*5:f3. *. rV3r;$ *.'V V <V t API 04871 JW 12, Sr. Philip Erlator Bernard Cairoraitgr School of Public Bcclth 55 tOmttmk street Boatoa 15, Mm. Sear Boatar Ifcrlatort Ode la la reply to pear lettor of Juaa 30 tuai reaalto from aj lattar of /iy 6 to Doctor Iea, a copy of toioA w eea* to yea. Doctor Seas aacpwto that I ratora tto iaroiea to 70c with rc*acat that It to paid tram year current faada alto tto aoiintoall^ toat toe Suto acoalttoe on Panel ecitla Ccaooatrailopc etoal* rofuaat a n irreapnrtll-- laaraaee la tto aaxt ssrat to to .raaaaaaada* far H wnvl. aa oatllaad ia tto aoccod eltormtire rtated la agr lattar of M; 6 Tto laroiaa la gatnraa* toravlto. to traat ttot tola proaaiara will to tory truly 70m, DTB:d ea: 1 . C. lair* J. P. tolt k, I. Boat l. 1. Boat* API 04872 59 SO CONY-V ACUUM OIL COMPANY INCORPORATED sT*iai. relation* '* H. MONTOOMIBY * mamaur 2(5 Broadway, New York 4, N. Y. 1fr. D. V. Stroop American Petroleum Institute 50 West 50th Street New York 20, 5. Y. July 11, 1949 Rej "The Cutting Oil Dermatoses A Critical Review* by B. C. Xriete Dear Mr. Stroopj Your oonaunication of July 6, 1949 has been received and considered. In my opinion, I would suggest that Method #2 be oarried out. It would be such less expensive and would save a great deal of time. Method #2: "Request Dr. Drinker to pay invoioe from his current funds and request Medical Ad visory Comaittee at its next meeting to recommend corresponding inorease in payment to be made to Harvard on Maroh 14, 1950 from |10,000 to $10,139.61 for the next fisoal year." Very truly yours, AEHsDMM A. E. Hoag, M.d-- API 04873 Dr. a. X. Boat Sococy-Xamiaa Oil Coapaay, XBo. 26 Broadoay Wr lark *, I.X. Jkly 6, 19*9 Daar Doctor Boacs fer nor MHl4tntiCB and adrloo I aoeloao out of lattar dotod Jo* 30 final Dootor IBlllp Erlator vlth tfalak ho oat so as 1sk>1m So. 17311 ftroa fba Wini-- aad Vllklaa Cnfiny, Baltlaoro, Maryland, aanwatlna to $139&1 to ooaar "aharfa far Irtlll^ artialo 'tka Cmtti^ Oil Daraatoaoa - k Critic*! Sarlor1 ^ By B. C. XTlato." I I flad ^aalf waaBlo to pa? tkla laa>ieo aa oar | azpoadltaroo aro 1MW to --rata wnaaartal By tka Nadleal IdTiaory Canalttoo and ayprvwd By tka Safety Coatlttao of the lord of Director*. %* tdll recall tht $2,300 too paid to Barnard OniT*r*ity la Bmartar 19*7 to romtaro* tk* U1 fnd tharv for , eoota la tk* proparatli af the rertov. Mar tka tartar atrlot ralao oooaraiag oar of apaatal Dak, tkla aattar any to handled la oltkar of too an, aa ftllata* 1. Caaaaaa tka Madlaal Adrtaory Caanritto* By lattar af $139*61 lamloo and aoouro I tka Safkty Caaalttea of tka Board lattar tallat. to pay lsvelao fwn kla Mrtlaml Ad-flawy aaat1a< to roeoanand la aaaat to Bo aada to ______ aa Barak 1*, 1930 from $10,000 to $10,139*61 for tk KLaua lot DIB: 4 ee: Doctor*: T. C. Baird Wily firm J. t. Bait B. B. Barra tlo* joa truly yean. API 04874 Industrial Hygiene * HARVARD UNIVERSITY SCHOOL OF PUBLIC HEALTH 55 Shattuc{ Street 'Hoston 75, i_\lassachuset:s -- * V D uT'C'Ojj American re^rcleum institute 50 Ass1 50th Street Mew Ycr.< Yity 1 Year Mr. Streep: herewith sill Yor pljP.ul Yor .tilling the article cr. gutting ills as per vote ef API Medical Conciittee at "etroit last April. 7cu will renercber that the paper actually was in galley prccY, having seen approved by the comittee, then ap proval was withdrawn and we were stud with tne cost of print ing the galleys. I do not think it would ce fair tc charge this against cur own special budget. Please advise. c.nc. API 04875 Jtilj 15, 19*9 Er. Sobort A. JQetaoe .Tsttorlag Ijtent7 of ApplloA rfejelologj CoLUes of M*Alela* Balienltj of Cleelamti Claolaoati flfclo Daar Doetor tehee: lfcie ie to eciarwrleAge receipt of the teo swated eofloo of the MMtlmattioB c^reeavat of <7bb 30, 19*9 ad to enelaei the metltate'c entci in the Mmat rf i*9,*13 la onnnrilonrn vlth the terae of the nari--nt. Jmrj twlj jean. DTStd Sr! MiTver Weedy API 04876 UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE CINCINNATI IE. OHIO LABOBATOBT of applied physiology July 18, 1945 CABLE ADDPMI; KETLAB. CINCINNATI TELEPHONE; UNlVMPITY MSB Mr. D. V. Stroop, American Petroleum Institute, 50 West 50th Street, New York City 20. y, v /\ Dear Mr. Stroop: I herewith acknowledge with thanks receipt of American Petroleum Institute's check in the amount of $49,413.00, covering expendi tures to be made on their behalf. Very truly yours, E. P. Fortlage, Secretary lo Dr. Kehoe ef API 04877  04 UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE CINCINNATI 19. OHIO laboratory op applied physiology September 1, ly49 CABLE AOORSSSi KKTLAS. CINCINNATI TELEPHONE) UNlV Mr. D. V* Stroop, The American Petroleum Institute, 5j West puth Street, New York City 2u. ' Dear Mr Strocp : 1 I send you herewith an account of the expenditures made on behalf of the A.F.I. project for the second quarter of 1949. Very truly yours. E. R. Fortlage, Secretary to Dr. Kehoe ef Enc API 04878 UNIVERSITY OP CINCINNATI KETTERING LABORATORY ACCOUNT OF THE AMERICAN PETROLEUM INSTITUTE FOR THE SECOND QUARTER OF 1949 >lBlES (Based on Proportion of Time Actually Spent on Project) Francis Heyroth - Chemical and Toxicological Asst. A. Wesley Horton - Chemical Assistance pan Duvall - Technical Assistance Vfm. Poynter -" " Karl Korpi -" " .. Sylvan Witherup - " " 152.48 1800.00 28.85 38.74 113.24 10.77 2145.08 rtTTLANEOUS EXPENSE f purchase of Animals Laboratory Supplies Traveling Expense ................................................................................... proportion of Secretarial, Library, Janitors, Wash Boys, Draftsman, Shipping Clerks, Animal Caretakers, Hlstopathological Preparation etc ................................................... proportion of Heat, Gas, Electricity, Steam, Gas, Telephone, Maintenance , Pensions, Annuities etc 87.00 990.92 1400.01 550.62 600.61 5774.24 Balance Remaining for Work in 1949 ,,_ at End of First Quarter 1949 .................................$16,222.85 Expenditures Second Quarter 1949 ................................ 5,774.24 Balance Remaining for Work in 1949 ............................ $10,448.61 Receipts - July 18, 1949 ................................ 49,413.00 Total Balance Remaining for Work in 1949 at End of Second Quarter 1949 ....................... .... $59,861.61 API 04879 October 19, 19^9 5r. McTrsr Voodj Xaeo Standard Oil Conpeny 15 Vest 91st Street Be* Tor* 19. I.Y. Deer Doctor Vfeojx Toe jckec iafcraetian ve enclose copy of budget data supplied to ao by Doctor Eeh.;>c vtth his letter dated October Ibth. T.-r;- truly yeuro. WS:d Xnclesnre API 04880 October 19, 19*9 XT. Robert A. Xfcfcoe Ual-rerelty at C laclanetl Thm Uttering Laboratory Collet* of indicia* Claclaoetl 19, Ohio Seer Doctor Xfcboe: Tfcenlt you Ter/ *acb far your letter of October 1* end the t*o oople* of the eetlaeted bedeet on the API earoloogmloltj project far tbe fleeel jeer 1950-31. Jar7 truly your*, DV8:d API 04881 . anTrTrtM*'"s L**OR*TO"' ` gt Of OICINE--DE1 OHIO r\ UNIVERSITY OF CINCINNATI DEPARTMENT OF PREVENTIVE MEDICINE AND INDUSTRIAL HEALTH October 14, 1^49 CABLE ADDRESS; UTLA*. CINCINNATI TELEfHONE: CAMTOl UI4 Mr. D. V. S:roop, the .-xierican Petroleum Institute 5'J Vest 5'jth Street, I<ev York City 2j. Dear Mr. Strocp: < I am sending you herewith tabulated information in response to your request for it in connection with preparing the budget of your organization, in connection with our work, for consideration at the November meeting. This information may or may not be in the form in which you will wish to make use of it, but it will serve, I believe, to acquaint you with the outlook so far as we can see it. If there is any other information you require, do not hesitate to let me know. Sincerely yours EAK ef Enc API 04882 BUDGET DATA FOR AMERICAN PETROLEUM INSTITUTE Investigation of Cutaneous Carcinogenic Materials by Lettering Laboratory Schedule I Program vith respect to Petroleum Technology and Epidemiology, on behalf of A.P.I., (excluding testing of materials by means of mice; Compensation for Personnel July lS4s to July 1950 Estimated Estimated * April 1949 October 1949 July 1$50 to July 1951 Estimated October 1949 Supervision $ 2,500.00 $ 2,50u.0u $ 2,500 ju principals - Petroleum Technician Epidemiologist 7,200.00 5,000.00 7,200.0u 2,500.00 7,2u0 .ju 5,00o .00 Assistant Chemists 4,800.00 7,200.00** 8,80u.oo Travel Special equipment Laboratory supplies 7,500.00 - . 5,000.00 7,500.00** 5,500.00 5,000.00 - 5,500.00 Overhead TOTALS ~ "~X7>V0Q .00 * 40,500.00 ' 17,700.00' j 55,100.00 16,660.00 48,000.00 f- , * Based on f lgures .eompletejor largely complete to October 1, 1949 ** Represents part'of year compensation for tvo assistants ** Represents allocation of cost (50#) of infra-red spectrograph, to the project BUDGET DATA FOR AMERICAN PETROLEUM INSTITUTE Investigation of Cutaneous Carcinogenic Materials by Kettering Laboratory Schedule II Program vlth respect to Testing of Materials by means of mice, on behalf of Petroleum Industry Supervision l 2,500,00 pathologists ' 7,200.00 path-technlclans 5,000.ou Animals 10,000.00 Technicians (animal tests) . 7,200.00 Becord Clerk . ..2A.00.00 .. Animal Caretakers (2). 4,000.00 Special equipment (Cages, etc.) Supplies Overhead 7,' 5y 00.0 0.4 . ; '^ytSQQJDO' un;ima _. .23,650.00 TOTALS ; 70,950*00 Estimate of Cost Borm/by Others mm, t Estimate of Cost for A.?. 1.70,950.00 *' '*_JcC- $ 2,500.00 7,200.00 3,000.00 2,500.00 4,980.00 2,400.00 . 3,000.00. 5,276.00 3,500.00 17,178.00 51,534.00 10,307.00 41,227.00 $ 2,500.00 7,200.00 4,CQ0.0j 3,500.00 5,200.0J 2,o0u .00 4,000.00 - 3,500.00 16,250.00 48,750.00 4,875-00 43,875.0V API 04884 BUDGET DATA FOI. AMERICAN PETROLEUM INSTITUTE Investigation of Cutaneous Carcinogenic Materials by Kettering Laboratory Summation of Schedules I and II Estimated Cost of Entire Program for A. P. I. July 1, 1949 to July 1, 1950 Estimated Estimated April 1949 October 1949 July 1, 195<j to July 1, 1951 Estimated October 1949 $40,500.00 70,950.00 $ 55,100.00 41,227-00 $ 48,000.00 43,875.uo TOTALS - Schedules I and II 111,450.00 94,327.00* 91,875.00 Balance on hand July 1949 59 Ml-61____ Estimated Requirement to July 1950 34,465-39. * This sum differs from the original estimate of April 1949 by reason of an error ($3*650) in estimating the overhead vhich also Includes cost of care (not feed) of animals. T ffg. a** 04885 API fcteart THIS END In slot of automatic tbjegraph *Hh messoge facing outward WESTERN UNION API 04886 n .a For Information Only - Wot For Publication Report to Subcommittee on Carcinogenicity of the API Medical Advisory Committee on PROJECT CN CARCINOGENICITY AT THE UNIVERSITY OF CINCINNATI 9-' The following discussion will be restricted to the technical aspects of the project- Doctor J. J. P.iair will attend the meeting in Chicago, November 10, 19^9, and will describe at that time his tentative plans for an epidemiological study of actual cancer cases in the petroleum industry. To date, process data on the various cracking and lube refining processes have been received from about sixty per cent of the cooperating oil companies. In line with the recommendations of the API Subcommittee in their meeting February 1, 19^9, the samples listed in Table 1 have been requested and are, at this time, either under test on experimental animalB or pending investigation. Samples of various cokes and heavy coker gas oils will be requested in the near future. Operating data on the various catalytic processes, not included in Table 1, are not yet sufficiently complete to permit any logical selection of samples. Of the "specific products" recommended for study, particular attention has been given thus far to the solvent extracts (Samples API-lh through 17) of certain lube distillates. Since these extracts should contain the major portion of any carcinogenic components of the original raw lube stocks, it is felt that testing of the latter can well be postponed until the results of the tests on the extracts are known. Further selection of samples will proceed cautiously until the survey of the cracking and lube refining operations covers at least eighty per cent of the oil companies. When that situation obtains, a list of approximately 100 to 150 samples from the various processes will be drawn up. This list will then be submitted to the Subcommittee for review before going ahead with the full scale testing program. To conclude this discussion of samples from typical refinery streams, we should like to offer for consideration the following sugges tion. It is felt that the data thus far obtained definitely rule out any possibility of the use of boiling point alone as a sufficient criterion for determining the dilution of a carcinogenic oil necessary to permit safe handling. A single case might be cited. A typical heavy catalytically cracked oil, containing less than ten per cent of material boiling over 700 F., has been tested on mice in the usual manner. Half of the animals given adequate exposure developed tumors, most of which were found to be malignant on postmortem examination. Hence it is urged that as much atten tion be given to the concentration of the aromatic component of an oil as to its boiling range in considering any formal recommendations on dilution. 1 I1 9 `i i i f 04887 2- - The experiments previously mentioned., in which various concen trations of a standard, carcinogenic hydrocarbon, ttothylcholanthrene, in benzene are being tested, have proceeded very satisfactorily. The results will be presented graphically at the Chicago meeting. It has been found that with the C3H strain of mice, used in testing the first 8 oils, that the concentration of methylcholanthrene is inversely proportional to the times of appearance of tumors in the different groups of mice. Thus, with the C3H strain of mice the benzene solutions of this carcinogen offer an excellent set of standards for reporting the relative carcinogenicities of the oils to be tested. Simultaneous experiments with a CFW strain from the Carworth Farms have brought out interesting differences in the effects of the polycyclic aromatic structure on mice. Based on time of appearance of tumors, this strain is more susceptible to the lower concentraions of methylcholanthrene (below 0.2 per cent) than is the C3H strain. Hence the CFW strain may be useful in accelerating the determination of relative potencies of the oils which are only mildly carcinogenic. However, perhaps due to some general toxicity of high concentrations of methylcholanthrene for this particular strain of mice, there is no further shortening of the induction period with concentrations higher than 0.2 per cent. The technical personnel required to handle adequately the work of the carcinogenicity project are now assembled. The predicted expansion of the animal testing program may require an addition of one non-technical assistant. The group handling the actual testing of oils on the mice remains essentially the same as previously reported, with the addition on July 1st of Dorothy A. Templeton, B.S., who is responsible for keeping the records of the animals and for bio-statistical studies. Pathological examinations of sections are being made by Frank P. Cleveland, M.D., and Frederic Shaffer, M.S., under the general supervision of Frank E. Dutra, M.D. By July 1, 1950, the animal testing program will be amplified considerably, involving about 6,000 mice required to test between 150 to 200 samples drawn from typical refinery streams. Further developments in the direction of an analytical tool based on the physical properties of the streams should aid in the selection of the samples. Further experiments are contemplated using standard carcinogenic hydrocarbons, such as Methyl cholanthrene and 9,10-Dimethyl-1,2-Benzanthracene, in both a non-volatile solvent, dodecylbenzene, and in some solvent of very high viscosity to stimulate thermal tars. Experiments which have already been started involving washing animals with soap solutions at definite periods after application of a carcinogenic catalytically cracked oil will be continued and expanded. TheBe tests have not been running long enough yet to permit more than a statement that the normal time of appearance of tumors has been delayed by washing. Lastly, mention should be made of the fractionation studies being carried out in our chemical laboratory. Russell Tye, M.S., has been engaged in this work with the Laboratory since July 1st, and on October 3rd, Ruth C. Pierle, Ph.D., Joined the group. Much of the work has been with Oil W-3632 (API-8), and with another FCCU decanted oil, API-12, which is a somewhat cleaner product to work with and about equally carcinogenic API 04888 to mice. Progress towards the development of a rapid analytical tool, which might be applied to any refinery stream to determine its carcino genicity, has been very satisfactory. The technique is, at present, being applied to all of the oils which have been previously tested for the American Petroleum Institute or for individual oil companies. Details of the method and results of its application to the various oils will be discussed at the Subcommittee meeting, November 10th. October 25, 19^9 A. Wesley Horton II-2-U9 04889 TABLE 1 "API Sample number . Process 9 TCC 10 TCC Product Syn. Tower Bottoms Fuel Oil Gravity 18.4 11.6 11 Houdry 12 FCC Syn. Tower Bottoms Decanted Oil 4.3 18.1 13 Polyforming Polyformer Tar 9-7 14 Solvent Extrac- Extract from 10.3 tion (Furfural) Kansas 200 Stock 15 Solvent Extraction (Furfural) Extract from Okla. crude (for 400 Pale) 10.9 16 Solvent Extraction (Phenol) Extract from 900-X Coastal Distillate 11.0 17 Solvent Extraction (Duosol) Extract from Calif. Waxy Desiduum 7.0 18 Viscosity Cracked Breaking of Desiduum API 17 and San Joaquin Asphalt 6.0 19 Naphtha Deforming Deformer Tar 17.0 - Wax Pressing Slack Wax from Lima Crude - FCC Heavy Cycle Gas Oil 26.1 Thermal Cracking (DeFlorez) of FCC Heavy Cycle Gas Oil above Thermal Tar 13.5 Boiling Dange 425 756 F. 550-92$ at 76o 438-81$ at 700 435-74* at 750 440-75$ at 740 705-920 720-95$ at 960 790-50$ at 915 650-50$ at 950 355-94$ at 706 427-828 373-95$ at 1050 UOP "K" Factor 10.7 (70$ aromatics by silica gel) 10.7 9.8 11.3 (50$ aromatics by silica gel) 10.4 10.8 11.1 11.0 10.2 11.6 10.9 API 04890 COPY Mr. D. V. Stroon October 31 1949 (air mail special delivery) Dr. Mclver Woody, Medical Director, ESSO Standard 1$ West 51st Oil Company Street, Hew York 19, N. I. Dear Doctor Woody: We have again reviewed the interim progress report submitted to- you last week. Since none of the samples at present under test are far enough along to per mit any definite concluetops.regarding their physiological activityr it is fait that nothing more could be said about that phase of the: program. . M indicated \in paragraph 4 of the report, our plans for .animal testa of auch materials in 19gd are necessarily on a..tentative basis. Ve have reason to azpeet that we.ehail probably have 80 per cent of the companies represented os our data aheats within the next two months. Our fell seals tasting program on refinery samples for 1950 can then be organised and submitted to the Sub-Committee for review. The necessary equipment for the fractionation work in tha ehemledl laboratory paa net available until about July 1st. 8ammar vaeatloan postponed active initiation of these studies ustilrAugust* ^Hapca I am.not unpleasantly surprised toadied myself-in: a,position to,discuss even in a preliminary-manner, data which we.believe will lead to a use ful analytical tool in. the determination of the carcinogenicity of petroleum products. .. - ' Thua, while many aapacta of the project, plans for which haws beenpreviously reported to the Sub-Committee, have recently gotten under wey, it la felt that the results of the present stage of the work hardly warrant any formal and lengthy discussion. API 04891 Dr. Mclver Woody 2 October 31, 1949 To complete the discussion of current work, I am adding the following paragraph to the report (to appear on Page 3 just preceding the final paragraph): By July 1, 1950. the animal testing program will be amplified considerably, involving about 6,000 mice required to test between 1.50 to 200 samples drawn from typical refinery streams. Further developments in the direction of an analytical tool based on the physical properties of the streams should aid in the selection of tfax samples. Further experiments are contemplated using standard carcinogenio hydrocarbons, such as Nethylcholanthrene and 9,10-Dimethyl-1.2-Bensanthracene, in both a non-volatile solvent, dodecylbenseae, and in some solvent of very high visoosity to simulate thermal tars. Experiments whioh have already been started involving vaahing animals with aoap solutions at definite periods after application of a carcinogenic catalytically cracked oil will be continued and expanded. These tests have not been running long enough yet to permit more than a statement that the normal time of appearance of tumors has been delayed by washing. Since receiving your letter of October 21st in which you indicated your concurrence in the idea thatthe members of the Sub-Committee should be given an opportunity to review this progress report before the meeting, I have talked with some of the members personally. All have been quite pleased to hear that they would receive the report in advance* Hence, with the inclusion of the preceding paragraph, I hope that you will find the report which you have in hand suitable for distribution. I can assure you that tbs technical aspects of our work are covered completely therein and could in no sense be rendered confusing by any thing I plan to say on Movember 10th. The graphs which I ^pX 04892 Dr. Mclver Woody -3 - October 31, 1%9 shall bring to the nesting show only the preliminary results of the aethylcholanthrene experiments, which are by no neans complete as yet and include no microscopic examinations. You will recall that last Wednesday we discussed the choice between lantern slides and photostats. Since we were in agreement that the incomplete nature of the experiments did not warrant a permanent record, 1 shall present the data we hare on slides as suggested. I believe that the members of the Medical Advisory Committee would have a much better opportunity to talk over the program with their technical associates and prepare their suggestions concerning future work if they did receive this material prior to the Chicago meeting. However, if you wish, I shall have the report mimeographed here to be handed out November 10th. If this is your desire, please advise me by Friday, Noveaber 4th, so that our secretary will have time to do the work before I leave Cincinnati: on November 6th. Sincerely yours, - A. lfesley Horton AWH:fe '* ' cc: Mr. 0. f. Stroop PROJECT OK CaRCIKOGEKICITT *T THE UHIVEKiXTT OF CIKCIHMATI Tbe following 41a eusion will be restricted to the technical aspects of the project. Doctor J. J. Phair will attend the nesting la Chicago, November 10, 1949, a&d will describe at that tine hie tentative plans for an epidemiological study of actual eanear cases in tha patrolsuta industry* To data, process data on tbs various cracking and lube refining processes Have bean received froa about W> sixty per cent of tbe cooperating oil coapaniea* In line with tbe reeoaaeadatlons of tbe API Sub-Coaaittee in tbeir aaating February 1, 1949, the aaaplas listed in Table 1 have been requested and are, at this tine, either under test on experimental nnlaals or ponding investigation. Staples of various tokos and heavy coker gas oils will bo roquMtod^ia tbs. soar future. Operating data on the various catalytic .professes, not includod in Tablo 1, are net yat;auff^ciefily-aoaplata to permit any logical selection of taapitt, * of the * specific products* resoMBfuded .for, study, -psrtlsular attention has been given thus far4to the-solvent extracts {Samples API-14 through 17} of Cfrtain.Iubddiatillstea. Since these extracts should contain :tbo asidr portion gf any carci df nogenic eoapeiMot* of the original raw lulo Stgeks, it is felt that testing of the"letter sen well be postponed untiJ^th*.gftfulte the.extracts ere known. < , t ,u g T* H 'rr; tr r * ?* ',.1. ~ i J" Jiirther etlectioh cf gentles Will proceed cautiously until the surveyv#f the tracking and lube refining opera- tiopecovers at 4ehft 10 per cent of the oil conpeniee. bhetrlbat situation-obtains, a list of approximately 10a,to^l50 oenploe from tbs various procatena will be drawajup. This list gill-then,be submitted to the Sub- Cendlttee for review "before^gging aheadjdth the full seals testing program.' API 04894 To conclude this diccuscion of cample c from typical refinery streams, wo hoaid liko to offer for consideration the following suggestion. Zt is felt that the data thus far obtained definitely rule out any possibility of the use of boiling point alone ns a sufficient criterion for de termining the dilution of a carcinogenic ell necessary to peralt safe handling, A single case night ho cited. A typical hoary catalytieally cracked oil, containing less than 10 per cent of naterlal boiling ever 700* F., has been tested on nice in the usual manner. Half of the animals given adequate exposure developed tumors, most of which vere found to be malignant on pestmortem examination. Hence it is urged that as much attention bo given to the concen tration of the aromatic component of an oil as to its boiling range in considering any formal recommendations on dilution. The experiments previously mentioned, in which various concentration! of a standard carcinogenic hydrocarbon, Kothylebslanthrene.-in bensene are being tested, have proceeded very satisfactorily. The results will be pre sented graphically at the Chicago meeting. Zt has been fomnd that with the Oh train of alee, need in tooting the first I oila, that oho concerntratlsn of aothylcbolanthrono ia inversely proportional te the timet of appearance of tamers la ths differemt groups sf miss. Thma, with ths C3I strain of alee ths bsnsene solutions of this serelasgen offer on excellent 004*01 standards for reporting the relatlve eartimogeaiofttloo of-the Clio to be tooted. Simaltaheoiiseapertnehtm with a CFV Strain from tbs Cnrwortb Farms have breugheoat Interesting diffsrenees in the effects of the polyeyelie sromotie structure on nice. Based on time of appearance of tumors, this strain is more susceptible to the lower concentrations of methylcholanthrene (below 0.2 per cent) than is the C3H strain. Hence the CFV etrain may be. useful. Iil.accelerating the determination of rolativo potentlas of the oils which are only mildly carcinogenic. However, perhaps duo to some general toxicity of high concentrations of mathyleholan- threno for this particular strain of nice, there la no further Lfl g*nple jiiiMbar 9 10 11 12 i1 13 ' 14 15 16 <> 17 16 19 - Process .- Product -- ---- Gravity Boiling Range UOP *1" Factor . TCC TCC Houdry FCC Syn. Tower Bottoms Fuel Oil Syn.Tower Bottoaa Decanted Oil IS.4 11.6 4.3 1S.1 Polyforning Polyfaner Tar * 9.7 Solvent Extraction (Fnrfnal) Extract from tanaaa 200 Stock 10.3 Solvaat r r T street free isr* &n*racti*n - Okie-erode - dtftwii) Urnr iOft Pale) Solvent Extraction (Pbanol) ' Bstrost free u.s 900-1 Coastal Dietiliato Solvent Extraction (Duosol) Extract froa Calif. any Healduun 7.0 ?iaoo#lty Cracked Bracking of Beaiduun API 17 and San Joaquin Asphalt 6.0 aphtha Reforming Reformer Tar 17.0 Wax Praaalng Slack Wax froa Lina Crude FCC Heavy Cycle 26.1 Gaa Oil Themal Cracking Thermal Tar (DeFlores) of FCC Heavy Cycle Gaa Oil above) 13.5 425 756* F. 550-92* at 760* 436-61* at 700* 435-74* at 750* 440-75* at 740* 705-920* 10.7 (70* aroaatica by silica gel 10.7 9.6 (, 50^* *a3roaatica by silica gel 10.4 10.6 720-95* at 960* 790-50* at 915* 650-50* at 950* 11.1 11.0 355-94* at 706* 10.2 427-626* 373-95* at 1050* 11.6 10.9 API 04896 Esso Standard Oil Company Medical Department ES90 BUILDING. 15 WE9T 51ST STREET, NEW YORK 19. N. Y. jV^BJBDIWCAOLO0D1YII.KCMT. ODR. .US' S. DENHOLM. M. D. JUn`AH-lTA.*T MfO/CAL DIHBCTO* uOBK*r ** V- S1M*PBVBIMCIADM YPtTEB P LKONE. M. D. ' pBYMICIAN THOMAS n. ELIAS, M. D. CLINICIAN CLYDE M. BERRY. PH. D. INDDITUAl YOIBNIBT Koroahor 1, 1W. HA All HAtt Dr. A. Vooloy Norton Onlwmroity of Ciaelnati Dopartaont of PTOTontiw* Modiein# sad Industrial Health Cineisati 19, Ohio Doar Dr. Horton* Cm roo*trine four lottar of yootorday, I consulted Dr. Boar aod Mr. Staroop, both f mhos worn* omits milling to guidod "by jronr d*alr to hors your urogrooo rooort ciroolatod nrior to iho sooting. In lino with your roqsoot, tto additional gr*Tnh *>y July 1, 1950 delayod by waohing*. will bs inoortod jmt Wforo th* concluding naragroreh of your rouort. tncoroly, XelViHB m trrt1 ee /Dr. A.*. Hoag Mr. 3.T, Stroop API 04897 October 25, 1949 Dr. Mclver Woody, ESSO Standard Oil Co., 15 Vest 51t St., New York 19, N. r. Dear Doctor Woody: I an attaching the promised report for distribution to members of the API Medical Advisory Committee prior to the Chicago Meeting. 1 am looking forward to seeing you on Thursday or Friday. I shall telephone you when I arrive in town to arrange a suitable time for a meeting. Sincerely yours, : . . 1. Wasley Horton AH:fe end. cc: .Dr. A. E. Hoag, vMr. D. T. Stroop with attachments. API 04898 rorrFH>ENTIAL D For Information Only - Not For Publication AMERICAN PETROLEUM INSTITUTE SUBCOMMITTEE ON CARCINOGENICITY \N- *v ^V ' Minutes of Meeting November 10, 19^9 Stevens Hotel Chicago, Illinois Members Present Associates Present Marshall Clinton L. E. Curtis T. M. Frank T. J. Kelly M. N. Nevquist C. A. Swan Mclver Woody L. C. Beard, Jr. A. E. Dooley R. W. Faulk H. G. M. Fischer H. P. Lankelma Visitors W. 0. Armstrong F. F. Boys J. W. Crooksh&nk Kieffer DaviB A. E. Hoag E. K. Linder J. W. Long B. B. Reeve E. W. Adams C. T. Brovn E. c. Cole N. J. Gothard L. M. Henderson C. A. Nellson R. M. Shepardson F. M. Watkins Guests B. D. Bent - The Atlantic Refining Company E. E. Eckardt - Standard Oil Company (Nev Jersey) E. A. Evans - :President, Institute of Petroleum, London A. V. Horton - University of Cincinnati W. J. McGill - Standard Oil Company (Indiana) E. c. Mlthoff - California Research Corporation J. J. Pbair - Univarsity of Cincinnati V. D. Seyfried . Humble Oil and Refining Company H. R. Warrick - The Texas Company W. 0. Wilson - Standard Oil Company (Indiana) Advisor D. V. Stroop - American Petroleum Institute Total in Attendance - 39 Members Absent J. P. Holt W. E. Levis K. G. Mackenzie API 04899 Nev members and guestB were introduced. Minutes of the June 3> 19 interim meeting were approved. Dr. A. Vesley Horton. Assistant Professor of Industrial Hygiene, University of Cincinnati, reviewed briefly the progress report which wbb sent to the subcommittee members prior to the meeting. He said that data obtained so far indicate that the use of the boiling point alone is not a sufficient criterion for determining the dilution of a carcinogenic oil necessary to permit safe handling. The aromatic content must also be taken into account. Dr. Horton presented a series of lantern elides to show the progress being made at the University of Cincinnati toward developing an analytical tool. The technique is being applied to all oils which have been previously tested on animals at Cincinnati. This predicted expansion of the animal testing program may require the addition of one or two non-technical assistants. Dr, J. J, Phair, Professor of Preventive Medicine, University of Cincinnati, in discussing the epidemiological aspects of this problem reported on the advantages and disadvantages of various approaches. He proposed the establishment of a cancer registry for the petroleum Industry at the University of Cincinnati and submitted a preliminary form for recording data on cancer cases. He requested that the subcommittee members submit suggestions as to changes in the form and how it should be used. It was the consensus of the subcommittee that legal advice be obtained as to whether reporting such cancer cases to the University of Cincinnati would be an invasion of an individual's rights. Dr. Elliott A. Evans. President of the Institute of Petroleum, London, reported briefly on the cancer problem as it relates to the petroleum industry in England. He said that in England the chief interest was the problem of effects on users of petroleum products. He requested that the exchange of information between the API and his organization be continued. Those subcommittee members who had written articles on cancer for their company employee publications reported that such articles had caused no adverse results. The subcommittee recommended to the Medical Advisory Committee that: 1. Exchange of information between the API and the Institute of Petroleum, London, be continued as during the past year. 2. Legal advice be obtained as to whether an oil company has a right to report cases of cancer that occur among its employees to the University of Cincinnati. 3. Adequate funds be allocated to continue cancer research at the University of Cincinnati for the twelve months ending January 30, 1951. A. E. Dooley Secretary Mclver Woody, M.D. Chairman 11-28-1*9 API 04900 1< CO s # e rH a 03 p 3 H -P ft C3 >. CD P 1 p P S to ---- l XI 0 P n-4 pi as P 03 0 O as p ' T3 O1 CO CD fp 0= 1C I3 CA *w --' <1 11 OO Q> U) 1 ! IT. GO 4J CO 1 i p >3 i 1 0 * rH C mp 03 Pi >3 03 CD 03 E cc * 3 p +3 Pi 1 03 E 03 a! 3 X! C3 3 ft 03 CO CD SZ H f4 CC & Eh >, CO 4J 1 >- w -l 1 rH ft ! 1 31 n C o *. P CD p o 1 S3 1 > 5 3 P < 1c 1*3 ft X 0 03 O 03 1 1 CO . 1 >> U CD | CD V *-- E -p C3 lH O 1 b CO CO 0- n H a3 O Fh S5 Q tc r? E> I&H M Pc' nt'o cccp t: C Eh or cc CO --O *--* 4J C C\J 0) bU T3 p - -C__- r-t rH k a C CM oO 6 P< 1 I sO CM u S3 I m H CM. P 0v >C S3 P 03 LP S3 S3 to .11 03 I os C ,0_.a^J4U3S P 1 P CD lP|T3!o CD I P 1 |s> o CS CO j 03 03 1 P >30 iH jH jC CM CM 1 1 !& p. w_* * 1 IA W 1 Pw 03 CD tc a: p1 1 3X 1 co I I >s XS TJ S3 *3 P o a S3 c= CM ** U -P 03 O > 03 EP 3 -P E; co CO 03 p E so T3 T3 S= < r"\ vO 03 1 EP . o a) * 43 p O *! 03 (X p P *H u 1 J Mco CO < CO -- O1--I' E-i -? &3 o o -d-o Ss M S: ljH*- O< rH t-t --C5 CO M E-* *; 3C-O1 o CO &-> > 1-3 M oa i-3 O cr c CO o E- < E E- sr E- c<nd fA <3. a; 3H CM Q ft p -- API 04901 API 04902 I MEMORANDUM SUBJECT: RECEIPTS, EXPENDITURES AND ALLOCATIONS I November 10, i?49 API MEDICAL RESEARCH FUND Contributions Received 1945 194? 1948 19^9 TOTAL Expenditures Made Prior to November 10, 1949 ,$28,900.00 27 000.00 98,300.00 64,340.00 $219,340.00 Harvard University Toxicological Revievs Cutting Oil Study $37,000.00 2,500.00 39,500.00 University of Cincinnati Carcinogenicity Fluorine Study 120,413.00 5.000.00 125,413.00 Miscellaneous Books for Committee Use TOTAL EXPENDITURES BALANCE ON DEPOSIT 57.77 Payments Required to Continue Current Projects Unltl 6-30-50 164,970.77 54,369.23 Harvard University Toxicological Revievs (3-14-50 to 6-30-50) University of Cincinnati Carcinogenicity Fluorine Study (11-28-49 to 6-30-50) 38,963.39 1,500.00 TOTAL PAYMENTS TO 6-30-50 BALANCE AVAILABLE 7-1-50 Tentative Budget for Year Ending 6-30-51 Harvard University Toxicological Revievs 10,000.00 3,000.00 40,463.39 4L46.1J2 10,905.84 University of Cincinnati Carcinogenicity Fluorine Study 92,000.00 2,500.00 TOTAL TENTATIVE BUDGET ____ CONTRIBUTIONS WWDTO TO FINANCE TENTATIVE BUDGET 94,500.00 104,500.00 93,594.16 NOTE: If 1949 contributors should give 150$ of the 1949 contributions the total for 1950 vould amount to $96,510. API 04903 T Bomber lk, 19*9 Sr. Sobart A. Bibo* OnlTersity of Cincinnati Battering Laboratory of Applied Physiology Cincinnati 19, Ohio Dear Doctor Ksbosi At Its 19*9 usual neetii* the Instituted Medloal Advisory Coulttee totad to continue Its financial support to tbs cooperative study on flaorias at a rata not to saoassd $2,500 par rnr, Vs wish to change tbs annual data of paynent on this sooouat iron lawstir 2dth to July 1st to aaks it concurrent with otbsr special projeeta; tbsrsfars, se srs ri to sssA you $1,500 on Boraabar 28th to eorar tbs aszt ssran Months. Will this bo satisfactory to you? Tory truly yours, STB id API 04904 I UNIVERSITY OF CINCINNATI * department of preventive medicine and industrial health November 17, 1549 CABLE ADDRESS: EETLAR. CINCINNATI TELEPHONE: CAFITCU. MIA Mr. D. V. troop, American Petroleum Institute, 5J Vest pjth Street, Hew York City 20. Dear Mr . S.troop: I am glad to knov from your letter of November 14 that the Medical Advisory Committee saw fit to approve the continuation of A.?.I. financial support to the cooperative study of fluorine. -Any manner in which it is convenient to you to furnish the funds will be entirely satisfactory for our purposes . You will remember that we applied the first grant of fund^as at the beginning of the calendar year,which cane some months after the receipt of the grant Since that time we have continued to employ these funds on that kind of a delayed schedule within our own budgetary year, which coincides with the calendar year. Therefore, any means by which we receive the funds, during the continuation of this project will be wholly satisfactory. Sincerely yours, I |. ,1 f! 1 1 RAE ef i API 04905 ** American Petroleum Institute 50 WEST BOTH STREET NEW YORK 20. N. Y. November 25, 19^9 Dr. Robert A. Kehoe University of Cincinnati The Bettering laboratory College of Medicine Cincinnati 19, Ohio Dear Doctor Kehoe: Pursuant to the understanding reached by our letters of October 28 and November 5, 19^7 as modified by letters dated November 14 and 17, 19^9, ve are enclosing the Institute's check in the amount of $1,500 payable to the University of Cincinnati as our contribution towards the development of information on fluorine and fluorine compounds for the seven-month period ending June 30, 1950. Very truly yours, D. V. Stroop DVS;d Enclosure me: Mr. Baird 1. Markham Dr. A. E. Hoag Mr. Lacey Walker Members, Safety Cosmlttee of the Board of Directors Members, Medical'Advisory Comittee API 04906 * American Petroleum Institute SO WEST SOth STREET NEW YORK 20. N. Y. November 25, 19^9 Dr. Robert A. Kehoe University of Cincinnati The Kettering Laboratory ' College of Medicine Cincinnati 19, Ohio Dear Doctor Kehoe: Pursuant to the understanding reached by our letters of October 28 and November 5, 19^7 as modified by letters dated November lk and 17, 19^9, ve are enclosing the Institute's check in the amount of $1,500 payable to the University of Cincinnati as our contribution tovards the development of information on fluorine and fluorine compounds for the seven-month period ending June 30, 1950* Very truly yours, D. V. Stroop DVS:d Enclosure me: Mr. Baird E. Markham Dr. A. E. Hoag Mr. Lacey Walker Members, Safety Committee of the Board of Directors Members, Medical Advisory Committee API 04907 * American Petroleum Institute BO WEST BOTH STREET NEW YORK 20. N. Y. November 25, 19^9 Dr. Robert A. Kehoe University of Cincinnati The Kettering Laboratory College of Medicine Cincinnati 19, Ohio Dear Doctor Kehoe: Pursuant to the understanding reached by our letters of October 28 and November 5, 19^7 as modified by letters dated November lfc and 17, 19^9, we are enclosing the Institute's check in the amount of $1,500 payable to the University of Cincinnati as our contribution towards the development of information on fluorine and fluorine compounds for the seven-month period ending June 30, 1950* Very truly yours, D. V. Stroop DVS :d Enclosure me! Mr. Baird E. Markham Dr. A. E. Hoag Mr. Lacey Walker Members, Safety Committee of the Board of Directors Members, Medical Advisory Committee ! { .j 'I 11 i t API 04908 American Petroleum Institute 50 WEST SOTH STREET NEW YORK 80. N. Y. November 25, 19^9 Dr. Robert A. Eehoe University of Cincinnati The Kettering Laboratory College of Medicine Cincinnati 19, Ohio Dear Doctor Kehoe: Pursuant to the understanding reached by our letters of October 28 and November 5, 19^7 as modified by letters dated November lU and 17, 19^9, we are enclosing the Institute1s check in the amount of $1,500 payable to the University of Cincinnati as our contribution towards the development of information on fluorine and fluorine compounds for the seven-month period ending June 30, 1950* Very truly yours, D. V. Stroop DVS:4 Enclosure me: Mr. Baird H. Markham Dr. A. E. Hoag Mr. Lacey Walker Members, Safety Consul ttee of the Board of Directors Members, Medical Advisory Consulttee a American Petroleum Institute SO WEST BOTH STREET NEW YORK 20. N. Y. November 25, 19^9 Dr. Robert A. Kehoe University of Cincinnati The Kettering Laboratory College of Medicine Cincinnati 19, Ohio Dear Doctor Kehoe: Pursuant to the understanding reached by our letters of October 28 and November 5, 19^7 as modified by letters dated November 14 and 17, 19^9, ve are enclosing the Institute's check in the amount of $1,500 payable to the University of Cincinnati as our contribution towards the development of information on fluorine wnfl fluorine compounds for the seven-month period ending June 30, 1950. Very truly yours, D. V. Stroop DVS:d Enclosure me: Mr. Baird H. Markham Dr. A. I. Hoag Mr. Lacey Walker Members, Safety Committee of the Board of Directors Members, Medical Advisory Connittee API 04910 LA.OHATORr 'VjS, or MEDICINE--COEN AVENUE OHIO 3 UNIVERSITY OF CINCINNATI department OP PNEVEMTIVE MEDICINE and industrial health November 29, 1949 CAMU ADDRESS: KETLAt. CINCINNATI TELEPHONE: CAriToi MM Mr. D. V. Stroop, American Petroleum Institute a 50 Vest 5bth Street, New York City 20. . Dear Mr. Stroop: I herewith acknowledge with thanks receipt of American Petroleum Institute's check in the amount of $1500.00, covering expenditures to be made on behalf of the Fluorine Project for the period December 1a 19^9 to June J>0, 1950* Very truly yours E. R. Fortla^A Secretary to Dr. Kehoe ef API 04911 Esso Standard Oil Company Medical Department Esso Building, 15 West 51st street, new York 19. N. Y. V , fVEB WOODY. M. D. * HIMCTOt pgS * DENHOLM. M. D .tnnAXT MBD1CAL D1KBCTDB P. SIM. M. T. 7iini MTMCiiir " D' THOMAS G. ELIAS. U. D. CLINICIAN CLYDE M. BEHHY. PH. D. IXDDITUaL KYOIRNIlf Deeeaber 1, 19^9 Dr. D.V. Stroop Aaeriean Petroleum Instltats 50 vest 50th Street Sew Tork 20, 5T* Dear My. Stroop* Ag requested in your letter of yesterday, I aa herewith returning the stateaant of expenditures aa.de at the lettering Laboratory. Very truly yours, XH Enc. hVI 04912 T fovwrtxrr 3C; 19*9 Ir. jfelYor Vooiy aso Standard Oil Cmpasaj 15 Veat 5Lat Street law lark 19, 3. I. Saar Doeter Weedy i Yor year Lafuraatlop and yaaltta eonest than la eonloaeA atateaaast of expenditures node at tha latterly Laboratory on behalf of tha kneriean Petroleoa Institute for the third quarter of 19^9. file. Please return the stateanst for ear ary truly jrewre, BTBtd Xnola API 04913 ^tfTTEA'Xe LAEOHATOHT , Qf NEDICINI--EOEN AVENUE JJeati n. OHIO UNIVERSITY OF CINCINNATI DEPABTMENT or PEEVENTIVf MEDICINE AND INDUSTELAL HEALTH November 2:, I?-- CAELE ADDRESS: KETLAE. CINCINNATI TELEPHONE: CApitol MU Mr. D. V. troop, Che American Petroleum Institute, 50 west pCth Street, Mew York City 20. Dear Mr. Stroop : I am sending you herewith, for your information, a statement of expenditures made on behalf of The American Petroleum Institute for the third quarter of 1949. If you have any question or comments. Doctor Eehce would appreciate your bringing them to his attention. ef me API 04914 t UNIVERSITY OF CINCINNATI KETTERING LABORATORY ACCOUNT OF TEE AMERICAN PETROLEUM INSTITUTE For the Third Quarter 1949 IES (Based on Proportion of Time Actually '' ' Spent on Project) prancis Heyroth A. Wesley Horton porothy Templeton Bussell Tye Karl Korpi Sylvan Witherup gdvard Svillinger l Carol Brown v^t.TJUTEOUS expense Chemical and Toxicological Asst. Chemical Assistance Technical Assistance R purchase of Animals 208.71 1800.00 404.84 750.00 110.38 53.05 22.24 4.50 3553.72 125.80 Laboratory Supplies Traveling Expense . proportion of Secretarial, Library, Janitors, Wash Boys, Draftsman, Shipping Clerks, Animal Caretakers, Histopathological Preparation etc ................................. Proportion of Heat, Gas, Electricity, Steam, Sts, Telephone, Maintenance, Pensions, Annuities etc . Total 12,635-83 ffelance Remaining for Work in 1949 at End of Second Quarter 1949 ..................................... $59,861.61 penditures Third Quarter 1949 ..................................... tlance Remaining for Work in 1949 at End of ThM Quarter 1949 ................................. 12,635.83 $47,225.78 i i! API 04915 ffaajarlVmtloM iMtlnd jLMP AT.TJWifjflfli >. HTC yBJpAIr ram 19*5 19*7 19*8 19*9 $28,900.00 27,800.00 96,300.00 6*.3*0.00 $219,3*0.00 11--Utiii'M lhd Prior to 1gmr& gnlfrilty VedMloclMLl Berlov* emttlac Oil BtoAjr 31. 19*9 $37,000.00 2.800.00 39,300.00 Bklroroltr of Claal--itl dorolaoconioity Jlasrla* Stodj 1*0,*13.00 $.300.00 128,913.00 gLootUoaeou looks for 1 37.77 tom nmncm MMI8I Oi MVOSXX ?W--t ItmlroA to CU$-- dyromt TnjtU QnU1^0r30 166. *70.77 3*.,889 .23 fcmrA Bnlnnltr toadoologieoi tori-- (3-l*-30 to 6-30-30) 3,000.00 OhlTgolty of 01iolmtl CnlM0raielt7 2*,#h22 WOm, IATKMTM TO 6-30-30 UlAWBX ATHLAtU 7-1*30 *1*963.39 10,903.8* hint far T*-- M***f jbdloal AtnM(7 mottIooo 3,000.00 Roarlao Stady *0 92,000.00 t.800.00 j*i329.-.9g. i?oq^s $ 58,39**16 1-10-30 API 04916