Document jBwd0VxEJdkgzv0vnyQrR6195

co ee Johnson BABY PRODUCTS COMPANY SUBJECT TO DemicronizTaeldc - 2006.01 Carbowax 400 - Aging Study Mr. G. Lee NB Sprick fam fam RARITAN N.J. 08869 June 20 1977 JBP exhibits a measurable reduction in airborne respirable particles ARP when treated with 0.25 carbowax 400 A further reduction in ARP is achieved by formulating the JBP with a demicronized talc fines removed and then treating with 0.25 carbowax In order to determine if the respirable particle reduction effect of carbowax 400 is permanent the following samples have been in 70 aging and tested over the past seven 7 months Sample # 1. 66 Talc Base - Lot 65374 Talc used to formulate samples 2 & 3 below 2 A JBP Form 499 Control - Batch 4681-31 A are duplicate samples 3 A JBP Form 3553-112-02 0.25 carbowax 400 Batch 4681-31B A are duplicate samples 4 JBP Formulated with demicronized talc 4365-48 and 0.25 carbowax 400 Results The respirable particle reduction effect of the Carbowax 400 is still effective and essentially unchanged after seven 7 months aging at 70 Procedure 250 grams of each sample and initially tested for as follows was placed in 9 oz airborne respirable JBP containers dust levels 729-10 Protected Document to Protective Order 0106917 JNJ 000339552 Demicronized Carbowax 400 Talc - 2006.01 - Aging Study Mr. G. Lee The container was placed in a mechanical device and shaken vertically at a fixed rate to deliver about 1 gram of powder The shaker is located within a closed chamber so that any airborne dust is contained within the chamber and is rapidly dispersed and uniformized by means of a fan The airborne dust is sampled with at a 1.7 min flow rate The cyclone small circulating a 10mm nylon cyclone separates out the respirable sized particles and delivers them to a TS1 3210A quartz crystal mass monitor for weighing of respirable particles as mg in the and printed out every 10 sec The concentration chamber is monitored Under these conditions the peak concentration of ARP in the chamber is reached in the first 10 sec after shaking This peak reading was used as the criteria to measure the effect of the and at carbowax 400 on JBP The samples one month intervals for three 3 were run initially months and then at the end of seven 7 months The average result of three 3 trials was recorded for each test A test consisted of measuring peak concentration in Mthe grams of powder delivered and the number of shakes An additional measurement was made at the end of seven 7 months aging only e.g. the average concentration of ARP in the chamber in the first two 2 minutes after shaking the can of powder Discussion of Data attached 1 The addition of perfume to talc results in a reduction of ARP sample 1 vs. sample 2 & 2. The addition of 0.25 Carbowax 400 results in a marked reduction of ARP when compared to the regular JBP Sample 2 & vs. sample 4 3 A further reduction in ARP results when the JBP is made using a demicronized fines removed talc Sample 3 & vs. sample 4 Protected Document to Protective Order 0106918 JNJ 000339553 7 Demicronized Talc - 2006.01 Carbowax 400 - Aging Study Mr. G. Lee 4. It requires more shaking to deliver the same amount of Carbowax 400 treated product from the container Comments This aging study will be continued to conclusion at one year by cc W. M. B. R. QS S. Russell H. Ashton Goodman to R. Gordon Semple N. Miller to V. Zeitz - Windsor Minerals Inc. attachment Protected Document to Protective Order 0106919 JNJ 000339554