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3Hmen wpr TECHNICAL REPORT SUMMARY
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w--CRL - Analytical and Properties Research Laborator: Trace Fluorochemicals in the Environment
T8DC 137-088: FM-3422/Monkey
0502
2000006
595
J.E. Long
Jon Belisle
88240
secomrvp 0 oon
GS
evwonoone:om aw CoRRERT GRRCTIVE:
ISSEY EN TM |Requestor:J.E. Long;
CAennatlryatlicaRlesReeaprocrh
Chemical/Analysi.
RES
-
Request IA69503;
3
Syn
Project $9172110004
:
REPORT AST Ra ry ms men ABSTRACT: (200-250words) This abstract infoirsdmistaribtuteidboythneTechnical Communications Canter
CLOSED ABSTRACT
-
Of monkeys from the IRDC subacute study 137-088. Furthermor The level of FM-3422 was determined in the serum and livers
total fluorine content was determined in selected serum
samples
F/NMR.
and
the
metabolism of
FM-3422
characterized
by
| 22 Contzin #71 wipy
33
e
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CENTRAL
Report
No... 8995 ANALYTICAL LABORATORY
Dat Augue st1. 6,1. 978.
tbject: IRDC 137-088: FM-3422/Monkey
equestor: I.E. Long...
equest No. AG9503.___..._ epost:
Dept. Name ..Toxicology.. Dated.. 8/3/78 ceeeeeee.
Proj. No.2172110004
Reference 137-088 study of FM-3422.
by IRDC was a The original
s90tuddayywassubsaectuteatRhtehesusfomlolnokweiyngtdooxsiacgiety
levels:
dosage
30,
levels
100,
of
103,00,30,1001000,mg/3k0g0/dmagy/.kg/dTahye.
study
It
awpapsearrsevi(sseede
with
Table
ETbehalecohws)egrroutumhpatancdotnhtelaiidvnoeesrdsagew4ermleoenvkeeelayscsh,weir2nedmiavllioedwuearalenlddy 2agsaufibenmmailtpetreidaosrftoforollatohnweaslsysstiusd.y.
Group.
Dosage Level
Survival
I
5
0
1 mg/kg/day
4/4
ass
III
3
4/4
Iv
10
"
4/4
v
30
3/3
SERUM ANALYSIS
tonkey
74708 74938
Dosage?
0 o
EM-3422 in Serum (ppm)
0
0
Total F in Serum
and
am
(ppm)
7467M
1
0
an
74897
1
o
am
469m
3
0.1
an
7474m
3
am
75
74878
3
0.1
an
L276
wil 46995
tenkeyTM 74754 7498
posage 10 10
74724
30
74998
30
-2=
_mu-3422 in Serum (ppm) nm 0.4
0.5 0.7
August 16, 1978
Total in Serum (ppm) 150 nin
375 -
Qt = Male, F = Female Bn mg/kg/day
hn = not measured
yItihahnesedispacenrarateuelsmdyesniottsfheato7fp4r7a2et4svheeenwraycsseerlpouofrnwepacfaoorsrneicdgeFnnNti-rf3ai4tc2ia2onnti.ndleiTvcoeatltaeldof tflhfualotersittdihedi"es.amcaoTrmhipeoorrunenfdore
for F/NMR analysis:
rcwTihaotetnhitoeNnMntoRofwosatFpshNe-ec3rto4rb2ass2eirgivunnesiddefidicca(ati8nne0t%dthbf(erlRauinoccrhhiaenredd/2pN0ee%awkmalrnikon)teaerdt).h.e
AprevsereynceMigofh. hPoGa-s9s5hed The bramchedssrono
abrgarnecahteedr/60e%xtelnitneatrh.an Ptheerhalpisnefaterhe.edinbgranscthueddy wiassomefrounsiswnvermceilieoed to
gTthHghee-s3e4nsf2tua2ilcaftloilsntyihcactlnoeacaairFdeMh."d-i3g4hf2Fr2uol,fmetvheitelhnredmioocfraetF,eCs-9t5htehwaatsstuFdMfy-o3u4wn2od2ulidnis itnmhgeestoesmneoorssiuimzreaennod to
sa1t3uggcceoosnmtcpselnetttrehalatytioFcnCo-sn9v5earpbtpueridolxditsmoatuFepCbl-oy9Sd5ylo1w0srliaynttchiewemiretsth'hrgearpseiimdaaocltnsyek,rey tthhfaaontlebrsarsrteobsse;rpathmeca3siibta
LIVER ANALYSIS
donkey 7469 74878
Dosage 3 3
EM-3422 in Liver(rg) 110
190
Ew-3s2z inLiver (ppm) 1.3
2.6
7472 30
1300
14.3
74997 30
4500
59.2
in mg/kg/day
-
ASR. $6995
-3-
August 16, 1978
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octnohnevseelsrisuvimeg)rni'n`wnhesehnFeMc-Lo3ime4pe2a2redtotothethe
iInninnauls? go2 2 greater
sdtleotenhsa3idtutritimhneegs fhtehimegahleesrtuadtcyhcaunwmausltahtaeesmfeelmaean.lde/,orIpneprsemeganapiisnrsiaogFnaMci-.n3o4il2sT2uhgoenalty
tivity of the female to this compan.
gesting
BL. /iz
n nBelisle Le