Document jBqb6b6kONbNBpK7z9L6g0kE2

Industrial Hygiene Digest June, 1965 558 Lung Cancer. Detection by Use of Electrical Skin Resistance Method. J.F. Fries end C.P. Richter. Arch. Internal Md. 113. 6Z4-634 (May, 1964). la a high proportion of patients with lung tumor*, abnormal pattern* of high and low elcctrieal skin resistance art reported. Many of these pattern* are due to lesion* of the sympathetic ganglia in the cervical and upper thoracic regions,, either from pressure or from invasion. A concept of a broader and often subelinical Horner's syndrome, detectable only by measurements of shut resistance is set forth. Other abnormal patterns of skin resistance associated with lung tumors are thought to be due to sympathetic hyperactivity referred to the dermatomes representing the lungs and bronchi. Other* are due to peripheral nerve lesions, such as involvement of the intercostal nerves by tumor. Still other bisarre patterns are at present unexplainable and nonspecific. Further experience with the method, however, may delineate them into specific syndromes. Possible practical applications of the method in diagnosis are discussed. Advantage* cited include speed, cost, paucity of false positives, superiority with certain tumor types, and lack of discomfort to the patient. .Am. Rev. Resp. DU. Abets. 559 Treatment of Pulmonary Aspergilloma with Amphotericin ,B. H. Ikemoto. Arch. Internal Med. 1 15, 598.601 (May, 1965). Isolated therapeutic successes in the treatment of bronchopulmonary aspergillosis have been reported following the administration of nystatin by aerosol as well as oral intake of large doses of potassium iodide. Parenteral injection of stilbamidine and, more recently, amphotericin B have also been considered to be successful in isolated cases. However, clinical effectiveness against deep.seated fungous diseases has been accompanied by a variety of disturbing side effects and evidence of toxicity during intravenous infusion of the drug. Fatal reactions due to renal or hepatic failure and drug hypersensitivity have also been recorded in the human. Furthermore, systemic drug therapy appears to nave particularly limited value in the treatment of free .lying Aspergillus fungus ball. There is only one preliminary report of endobronchial use of amphotericin B in the English literature In this report, amphotericin B was instilled intrabronchially by tracheal puncture in one patient with pulmonary aspergilloma. The in. stillation of the drug was associated with expectoration of many fragments of fungus ball. Subsequently, the fungus ball disappeared almost completely on the chest roentgenograms. There were no signs of side.effects or evidence o: renal or hepatic toxicity during the treatment period. 560 Pulmonary Aspergillosis: Diagnostic and 1mmmo.og:;*: Significance of Antigens and C.Substance In Aspergillus Fumigatus. l. L. Longbottoir. arc .' Pepvs J. Pathol. Bacterial. 88, 191-151 (July. :'69i Extracts were prepared from mstr-.', :i of broth cultures of_. fumigatus and other fungi. The number and types o: arvji* "irnr.ed varied considerably with the kind of culture medium employed and the time oi'-.ar *<:.*g Maximum antigen production by A. fumigatus occurred after three to five ae - .oatior. in Sabouraud's medium. Of 3CT patients with asthma, the, sera of 9% hae or? . . - :ungai antibodies; 63% of patients with asthma, transitory pulmonary tnfiltr*:. o* -1 eosmophilia gave positive reactions: and 98% of 57 patients with pulmonary rr.. :r-: -- ft ga e strongly positive precipitation reactions Moreover, the sera of patients in the latter -roc.;ed many more precipitin ares in gel diffusion than the other sera. Normal sera t.: 3'ta.n precipitating antibodies The in. cidence of positive skin tests paralleled :.-.e o: o' precipitins Following surgical removal of the mycetomata, the precipit.r.i -::e: 'o c.sappear It was also found that after prolonged culture of A. fumigatus an antigen . i troc.ced which is serologically related to pneumococcal C.substance. \ Jor.d from Am. Rev. Reap. Dis Absty. .v. J**,;* r: 'y. ^^V^**'* 01 132 2663 ij.