Document jBpBEo9kKXy9L8n2rp1RGKGd2

1 force eked "1i SSuiFgng M27o0s35c0a5 S3S16Cae1n0t0r0 n TWO YEAR ORAL (DIET) TOXICITY / CARCINOGENICITY + STUDY OF FLUOROCHEMICAL FM-3924 IN RATS 1 (RIKER Experinent No. 0281CRO012) i7 Conducted During April, 1981 - - May, 1983 1 Volune 4 of 1 RIKER Laboratories, Inc. / 3M Company St. Paul, Minnesota 55144-1000 U.S.A. ] 002491 Ir TERR ORALIDIET) TEnONC STUY TeCHuCIn TIA OFSnF-39E24u8 FGLa1t4l3ErdIeuntRATS . ST TooonrTE SemoenseT 2 (d55a0,e oess s . weer sz od I~ swFsoeyontaee ois 11s seesiHs ee6r1s a wm oor oheorerson smuov { i ffForroeetters BZ ais resiSLs Eeis 1 wm ees BmeEerson stu m . 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I: r Foa e t TNaMlA 8 a1e .a |1: mEi J ismI EmCFEEJon HEmaiysY :i. FD =TOUaLTmRe E 195 3 m3m34.I2a3 d1:s iEmmaEe23 i mML i memat . GmmEEnE odoo:wk mmwrla Eman set w .: sate ::de 2k oTTsolee alsa we sonneCl RBRnoeEEEL cor j e Sfs oe nie . 5E an%E:kL wm JTe oueG noie . EnsYmoson Ewa EY oLyT E E orsCE heTad deen mS p i ownnr . mmEed4i Su: oan smo F1 sdi mBFn HJe. ETneetkon enor qEBheey 002605 ne |. i . SCS Cu 1 aval ABLE L Ve si ea Fo 1 os peHEs -- ws :bn ohn L ns ARG 095 wre zz 5 mteaak . . : L . MpFotodionmkik1n92 . m 2JE6)4 7a0 k:15 EE6ee47 L FLLoFelie 1a0nse E0 oxE.5 e0 n02 | Fa wor is em mow sor |Sg frMoewms:I: mE on mE Ik wEwizy Bfa n PS 78: F Pa i | reiFOEOUneIAE s155 woieTnEHAgHrEhTs 18 een RnbeeXarow snr . mmEea onwewas mmsHEEanR dkok =fE3 ie LE spose She con tn sn goae #22. 4 ry gToowmmiE:BLo m ArfsLim- I-mS1GEL0End4 J Te RPihim rwp emiHEias fx om ffrp RoEhnR-- bYvwheoyoewr mer WY ESE : CTI) ses jis Hus 4b Ha mw welkR an W eWEnEdLod E= aei 002606 1119 !. BESTELTY" AVA ABLE I u . : I ARDIE2E BES Tod TE 70d. 76 - 1120 0602607 I:: [WI EST ALAN ABU L 1RE384T GES 545.75 545.75 I: 1 ear ess 602 6 -o. ez I: = . |: 1F03650 065 621.76 6 621.76 I! 1RE3352 6S Sr.74 6 567. 74 1: FOODJAR 16S 367.42 46 367. 42 0602608 1121 E51 Cue AV APPENDIX ITEM F - L TNOIVIDUAL GROUP MEAN BODY WEIGHTS, BODY WEIGHTS AND FEED JAR WEIGHTS OF FEMALE L RATS RECEIINVIDNIGETFLFOUROROTHCOHEMYIECAARLS Fi-3924 L | NOTES: Code Code 1 4 indicates indicates a a control FH-3924 group - 100 rat pon weight group rat weight | Code 5 indicates a FM-3924 Code 6 indicates a FM-3924 - 30 ppm group rat weight 10 ppm group rat weight - Codes 11, 14, 15, 16 indicates the total feed jar weight for ws the previous rat(s) AN weights are in grams --- 002609 1 122 5 CT mT rrr Appendix teen Tv Year Oroafl Fl(udioerto)caTroboxnici1t3y 2~4mcoingeRnaitcsity study Group Mean body Meiahes (9) + Standard Deviation Fenster Wstkady W contrRol B - 0 pmM02 wa1n00MpreE. S 01 mea3w0 pemso (02 we1s0 Bpomes ane g s&g SSDoo ommmasaiErowojdeeerlaen GWE els wbeelrseIona li n maesnliowaness 1p6s0a3. 1a0sGoo 2st bh G0 lseeaes e10s. Goom mies ee 8 1o WBaSkI m 20o0 W RIWSDE BEG) maneadli omnallien mele nl) 3Ba0dd Je: sess5o0 wo Go uaeest da G0 mmeeads h vs bi mweendss oanbiaee BWo ORDEARE mBaalsl) malm mo eX Bales sanehdE anies(s6) mweennid aaoen) amslaotd adees GG00 amd0i es 60 mmraei aae bien dias aes in H Zo opnsE OMaL ooonos won BME aammanliownes) adi phen 0s: 12s50500 Ndioents nmio0o ndere6d sswee iieer mmess aaiaee 2 0 SMT aL dmeaeln ele) HORII 060 ammmoaliommaaGlse aamlEei N3EEGS) a0s3d a as 050 OBme0dT e0d06300 adadss wwew aiee mes ese sand se ae I 2* Suimabmeirfiocfantandiimfaflesrawnecieghefdrom Control at 5% level (dumnett'a Tests g = 0.05) & . Em ome moo appends seen TM tea OrSaFlFl(uBsierto)caorixoinciPt3y3~24oncinogpeenttscity study Group ean Body tights (3) 4 Standard pevtation remsten msteay ceonmtemot e- e0 pTpmwr %L8 ommSmnaEir oLBeaiamllee NGomomornmlonimoswee S 4 non mm meerroaoopsswnen B Rn X Boom whihemiia opeostaen wan G G MEm EI s SLeeuu GB P0o oBem MeIl sesesreag w1n00Wpiln o mr mmmaemnnsdi SsoaaRhwiEnm saomseisdhobiaolwilenn ssnamasneddoeoSeaNnegEnn sseabdd nest oooahine bln ommmaehdliosSsnhhuuamn mmoeeelnddoahwlihiaannn w5R0 Wpieen mt aSmuneniei NtseUlsooenn oS wnldi5 onBoo0 ggye SwN0aI1lD LpEuuniggnn wDeeeld ae: BoIneg a0 SWwiDll 0 onDin0 i0en mwW ioI: I aGadlne wl10 5Bm e me mtsmaieeis mamosgesm nmmeaeiiiSontiam meell mal posgavoneoene 2 awmild opsaissee wl io) mmaeadtr eGaeaouuln a0Eenidi soooausnmw T"2 I] Suimobmeirtiocfananiimtaflerveingcheedfrom Control at Su level (bunnett's < Tents & = 0.05) 2 T r Toe -- [rr eo tear OroaFlFl(vBolorto)tarTiooxniciTt3y5=20cnicnosweantceity study Group man dy wont (9) Standacs seviation rome msooly momiwrowli- e0 pTmws R BBo oamwae:srd SB emi aBombOhaWan)n oslun EB oogm8 Bom wgwmeeer:loooeaehhbooonem ead oabos B 27m gmm elle moomamaneOenn JX200 mmmIaElDowWobhmooenon mwoomwmEealdl emonolhoomne w1l00Wplm o wr w20R7Em e ws wl oTmes mre SSaEaasGd mali GS0U0G009MWaN.nDd SU0D HISD mmweuennniiiooWnlhliilnp ii ogUO aGWlNRlDI W003 ommmmmeaOlilowmwoIl0iu0on mii wo0o weeens:ss wen: udSemwabltI whomhoh0oo0o swweaaniit wGewdhiioWmoSO0D9 GwwEeD: eoOana0e0 dil msmegosrrs sawmsseieee sel meus E0DU0D JI) wBmenrll gpmeeiowews moi open noonsommme easeeesdd oie ment ewSooonU sell omsooaonwn nein eSweeaedtd woDoannw ara. a OD ROOD wniroeee I2 5 tSioominricoafntanaimaflesresemirgneosom Control at 34 Level (bannatt's ents g+ 0.05) 3 L BEST wiv Vail ABLE I. ;t TECHIa E INITIALS S Ee oaeacreors = L BEE Eo Te ees == breonraaievss : weer L: Fispiereasveree 3g ea1s seeoorisooeoicsaisnagn 1i1a eesiie -; FiLofRcu0osSysEerEes 1ea3ai3sf ceeoourcressseeosesiiessnss ass0an i11a e3S23023 iusto ois eorroeiss So 1 Das 1 1RO4551 01S BO7EO014S. 40 1 145 4 . 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SEuu FODCINE 455 02GADOIGE 10 %51% RPoGdIESnIdz FOrGIRR O0GGG: 155 0prIeBsZeOoUsRTSiT G:0TeNISS oEnC 40 15 ifaiess es: azoses = wmsoe2 G2i0s5sa sFeex d zz e - Geesrex Z2i2n s2 wZein z3 2eaaz s5 2254..71 2a4e5 s2 276 . 244062 61 q20e5.83 2Z1o1e 1 2G7E2 2 7zz5 2z6s536 azzie3 0202.77s 22754.63 Zearr te 23212 2m00s : 2a410a.17 484.0 2e2s7e8 G20720.21 23a6s838 22a535.16 Z3i2a7.5e S2e%i0 e5 BESTCOPY AVAILABLE s253e 2G7e3d 1 - z39e34 219.6 1201 602687 meLmEINE Ea LPPWaOaglO miiadGIGgoUemlEreeRedREwnS EamiramER ek r pmmpelmlae GsIiUmg oEmiRmEnnS l EppwReomeCmEsnsIoOaatImmmNReETmnSllbG mLpaemlaEEmSagmmmeiaErnaa ie LmmeEAn AEsiaSaEEmemREaEnDnf Smr m mEoEe a LEr Ls NERe mEa EEDEG fLprlEaaetSldIL La SaEEENNrEERINERSE m apTasalE hmOiiMapOMErNRRrGEIeRISrIEi L m mEmm CaMEemn nrEEDRSA Of IfPpaEailEseslt a Na nEa r m NAR OW hmmoahmsSIp o IEEORl Ee NRIEEeESk8 p EeoonmseSEInEeonnma REEaIELEa Cfi LenEhoonekImelrLlBLiIloEEOnaIEmEENeAREnNSnnRdCOf IpEaSmeElITNoEnEmNiuLL B23 Ey:t BE EEHHirht =a =H.i i FSFriHt EEs2Set1 2gH=i.et H=Eztnt =2 EPHes 2 SFwtHi Ei i ir i nFBros =iFsHse 2"Ez:ii*3.2 SEi nitI % 002688 . BESTCOPY AVAILABLE 1202 WFiakinetea 6o0s% fGelsloeeiwoiezeerrs 0at0eh 6358 rFflooeistlet1bi5l roSihtieskeeaesrrie SSaEe 138 LFTeRUtIStEEsD bTiEs GoGlaisTEeeseisIeiniSTTo Bafu FFwieeodriie RfGuokiooicltseeeveeicsosns i 1s0 aSs5 FHoaailssiee oBTiiEfs oiSihfreeeestreerrsas e17n00 15s PLikeoiaaiocienns c6is3es% Gsoociesveoensreiese 2gZ0nn 488% EEPoEencEla 4GGE3EE% SEoifiEeeeRenimRaasIrEae 815% HLiEFoeiaenZiiaeis Gdeaopps cooiiiiisiteoocvnetasetsdsizadnno 185s LoIFmresaiinnes ooGioeif ocociciciseaoeoececteeesz etenon 518s FLnoeohlni G5GiEf oinoilisreeeossniierosas m mcnm B81% DHiiFUiaiNSiiEse GGe5iEEt SSaiaieweeomonzaez a10 :1% Frioaaiv:ein1o5gf5 ecoehaneotnairoorrdt ar0e 81% LhICiEReNI 5UGEE5E SmGhaiamteaoennreatss amove S5Is BSiRroeeahncieons GMooeEf: iMooalamceewiosirreaes sssene 8a5n FeiRaneuirtiel SdBoEI oEMcmcNIonnGeeicEts L3i0 f15 LFroieoetisiiteie8Ge5d:% wviirieitneemesrcsrEes 220 51% [FioFPchaaaiiers 1weii5sf ooGiiiocoetromooeoserases ev6n0 15% fFiRuFitaAioiinet ob1ou5:g Gcoiicecvftooboeesisersrss oa2no 155 H[iFRiielniitosh oG1ii5f: oecisiecttweeecoscrzeeezs ereoaa 51% SFSrRweUiItENtEsE BGGaiit:b sceierecreooonomiarss s10n :ie FFiFoaianiEiets dGeieef: oGeiiirrieismeaeccicseeersn asonun ae FfWreohiEeaie bEGeef EwooirrRiioonoEecoaes Swo ef138 i Szein e nsFeiel $Bi7s - Ea2el0 5aR5ita Ba Seel 2f0a5 = SBee EEHieNdr BaSeaill apec 2i5.ds6 F= E nfZetil i esi SFieiEa Fi =H: i=aeerd . FNerEl e25s27 Ei5e1 BEST COPY AVAI EHos4 _ E fZEeiEsdEs al 1203 002689 THO YEAR ORALCDIET> TOX-ONC STUDY OF FM-352E4r&wFCG-z1e4i3cReIRNizFATS TTEoCwHaNICIADNATIENSITEIAeLSe:S HH SFoEon NUNRERELR 0F-3E46L, 0-338 WEIGHT GF FULL FOOL JAF.S E2SGRANS EEK 13 1rpaeadssr7ee Foonank 0e1i5s 11% Geuorv1aEv0e3isZs4 serioescr aS2vO0 1141 iiRfeeddssrrsE FocoJk Goii:s 11% eGoavsieopecztise eevoniaz seud so 4141 Iifkeoidsseeln FoooIRE ooiiss 11% oeoorvrzoesnesdss oovseeier eebo 26 41 41 iiRRonidSseesr FocoaRe eolifs 115 eelloeleecezcsszz Diezeedis 2800 14 m1 freudssstess coia:: eolloosseeoeszesdr sseo Focolek 115 eleeosze 30 11 41 ii Raqassceer Foctane 6e1i5: 115 eilcorceccozzrees eleceoses S1o0 sn 11 41 iiFRoosseees FoooIne obiiss if GpiielsoeeeezzsEsi Dliidozes sdo0 To 14Li iFFoosssasn Foooiek o01i%s 11% @Giili3zGe0e2zecrs. Gilsmess 1500 so 11 41 iiFfeedassis:s Ficoiee ooiiss 115 eealiisseeeezssesd ouizepies seon 10 41 11 iiRroidssesss FoobJek ebiiss 115 eeiiiseeoeezssezs elzepesds 4s0v 10 11 11 iiRRooddssee:r Foooiak oGiiss 115 eciizzizeeoesseirr ezseesis esnn cu 11 11 GirRoessssesss FOOOJAR e1l5s 115 eiiozsovoezzezza 1250934 z1o0 0 14 41 iiRRooidccoolo Foouinr oeiiss 15 eolizzvsoesesseisz eizseoiad 4ab0 zo 11 1 RF1rkooBdOaeIcoRoE:s G01155 115 1Geii3331oz6ee0ee2zs77e6es 4400 2 41 11 LrosWceoned: Foooask eeiss 115 eeriissdeoveeisss e13coedes 3sooo 11 1 oiRioeecnesr Footink i61f5 115 oeiaziereeeeizosse eizeniza 3e0v ec 14 11 | i1FRooaascoess 6o1i5s Geiasdsseeoezzsrds 1700 11 322545..82 S35a0ra sGaezse f2iane6 7262 22 a5s2:6 a65s8 27s5.535 Z36es a8 2266154s 3Z6e471 2F7r.5 2o8a56s 3e0s5 14 z345e.1 33213754 21660..22 234652.16 3S010214 3Z4r4e.24 zSees s2 i25s233 aSoose x 23s20a 227583.17 002690 BEST COPY AVAILABLE . 1204 F1OkO0D9I6A1R0 11155 @O1l4a1z0e0e3z7e3n 4B0w 11 iFoseis eis plazesizd so 1 5a7s5.e4 za 8 . : FiOROeDiIeAiRe e11i5s 0ea1satsweoizeesr SToo 111 iFo4si: iS clageccos 0 1 622687 30 EGF iaDnitARs i11F5 0cllavaoseseesd STOo 111 1FGasis 015 piasoozEL 00 4 a3e6d0.5 ze1 FROEO4DEIIRER 6111S% 0G1i5T0i0e6e3z7e4E S3o0 111 RBagL? eis eizewsier en 1 32784.53 257 F1OFOGL4IzAiRe 10115 p01i5S3G6O623E6d3 S40O 141 1R04E1S IF 015500274 SO 1 e28s4s4 2745 F1OPOaDqIsAzRo 1G1i5 0e1i5s6r6e6e4e1r3s 7300 A1X iRoage1 eis eisseezss vo 1 a2715337 2587 FiOpOeDsJsAzRz iRudcz: 01e11i55s 0e115c9e6e603z975I eisieeiel 3S0 0141 sn 1 329753.s3 303.8 FiRooodDsJzAeR 1i1S5 0O1l6E230G0E3I5L1L 2T0O 111 1Fa4s25 ois pledoezes so 1 32m1172 288 5 FifoGoacziznse iFadecr 0111%5 eis oDilSEssoeeEecEeLd eiereocst 410G 2p 11 1 234841.14 297.2 FiOROnCqJsAzFe Rossa 1Gi1f5 ea 0o1l6e8s0e0e3I3o5n wiresezsr 63i00o 11 1 330905.26 2871 F1oFono4Jseten 1e1i3 eoil7rizceeesssess z7oo 411 1 4e31 els eirieozes so 1 e36a5s7 208 FioRoEt4iEeIRZ 1FA4533 G14155 Gif eeAl77SaReOeIsLsL plreeeiii sS2no0 1111 233381151452 FFoGoaoziamae Fo4cae G114i% 0eii7rSreeenzidadr pirseoes e1n0 Su 111 1 324470.3 265 FiOROOC4IezAeR @11155 eo1iEgleeeEnIi0iE 3200 111 1R04E37 015 18260238 BU 1 e0i3z 23 F1OROOC4IEA3R6 G11155 @11584300823%443 8100 111 1RO4E35 G15 eisSeezso iv 1 2G3az4a8 2801 F1OROOD45J4A0R G11155 eelisss7eeoeszedsl z4o 111 e34s124 ODIAR 1 509.7 0026391 1205 PRELRRLL iE2STCOPY AVAILABLE 002692 Ba 4 pre POSE BEE OLLZOGZTS BO ze 5 002693 - 1207 ry on 1 uEpoeecsrda aiioaitntnmee Eemnnlagdf1 m t LTeahkesSra umemn aemna 8 I E mpSd iGammoMaEeLnf58 Iwmjeeeeenn gSroSOEhniReanInELnsff& E ml meEO m gSaOa mRmEean NniE :fb& e DmreElmmE ElmroiMeaetn Ey f of p mn pRoe mmlaa naNnEmn eEEEnnlsnLdfLb pFoSeneeailiomAnaaSAeaTaemSemETnRsnnL 1Bb B en Ene ni H= 2 =h : miHoEfee EFsrhHe =[B=eriee #2 B=i3e = ooEBRr = = E=:i E=EHe3E =e He Toennd Bnraamm Gh DWLEOL GSeEnnn Ef4 ph be iielie sn 2 aBsi F=r 22 BESTCOPY AVAILABLE mnomadmEn Lo Eh 1208 002694 ROE TE deen i as "2: : 002695 BESTCOPY AVAILABLE 1209 THD VERE GRALCOTET> TOU-ONC STUDY TECHNICIAN INITIALS OF S FH-352E4ie'&oFCG-o1s4i3cneInNizR:ATS TSRooOhnROrnSuRnDAeRTeTSeE 33F0-E63M/4A18L5,E/801-336 Teton OF FULL FOL. Jn S 625GRANS ren iiFkoreoeatisjcteier o1oi1is%s coGooorrrscoeesenisazeses 78100 4 1 [iFRRoeeo4oisasrnrers 1eo1ai:ss ooooewsoeaseoeoeessisseess 4670a 1441 fiFRRooaesosseenss 0o11i1ss2 aoooooyorrmsooaoeezaseird7r 311000 1111 [fFRorOtaUcsSoeSe:Er e05i11s%: oeosllscoecsaooeoocessdtr s7Faa0 1111 F(iFoReoaanoceec:rs wp1ii1ss% Cociilooosdsoponondziesassc 2a5000 4141 iiFRPoaassisteeerr Gp1ia1fc% oodllieeocscewneezrszreai 5a000 4101 LTFFoRUGuSEEnE 10G11E%: oGeliiofieetpncooezzeeedrr So0n 04321 [iFrPoeansscseeo oo1ii1::% oooiiiiiisozceoocecerer7r eeedon 1111 SRFrooasssoeenc: oo1ia4:t% eoeididiigcseoeoeocreassz 5ssano 11a1 LfFProaalisoseitsni oo1ii::f eeeiiiiizeseoooooesssiesrss 37san0 4111 SiFRFoooiaossers: o1oi1is5s eeeaiiszsizsoeeoocsinasizzr e57a00 41a1 iiFFoRatahssiaenssns oo1ii%ss oooiiizssessvsoea0ssessd?s 8e30n0 1111 ifFrroeolsacsioenss oGoiiisss eoeiiisscrseecsceessseezdra 3s20o0 1111 iiFRRoooGssiccnoee:: o1oi1is5s oooiiisszezoceoo0zzsersrss 39s00o 1ia1 JfiFLR{ReOonsassdomoesseae11i1ts% aoeoiiik3zjsase0pe0ooe3sa0ssn%ze s0360a0 111b1 iFPorooadnaicenorer oe1ii1ss% oeoiiiszsseoooocbsaassesez 073a0a 1iLt irascos FROeOsDiIiAoP ois 0111s5 oo0ii1ss4cz1oe0oo0sz3ee6ss4363000 1 111 3E3r22r87 3E$5e5e?. aS37sa 3a 267 p5ero2ad eiisle 7SEAise rEee s3Eeels E3362e535 BBBEeree e5Fres 533034s3 F3H%iie 5330592578s ii25e5=<2 BEBESSTT CO!-COPY AVAILABL 32SG8e:7e . 32643s 12190 002696 F1OROED4EJ1ALE @111S5 011444300003372435B0O 111 33273a5e 11RR0G4I5E112Z e11SS 0e11446s0e0032163E 6600 11 236103.6 F1OROOU4I5A1R4 0111S5 0el1e478e0o0i3s0e7.4S0O 111 338003.49 FiLr09J6A1F5 o1i1s5 oeiiasseodoeziees7 0300 111 238627.3 11RFG034Ec11E7 0011SS 1155210000228660 S8a0 11 228860s8 : F1ORCeU4IsA1RE G21155 @15134000e326e0e. 4300 111 236808..33 | F1ORGO4DEJ1ASR 1@1155 @011556500664207s1 0300 111 2e7s1. 3 11RRee44Ec2210 @11s5 0ei1S5s7c6e032o8z7540 14 2e0z7.5a F1OROeD4JSA2R2 101155 e0115690@606327715 6100 111 32771516 F1OROeD4J2A3R 011155 0e1166120000330497.7700 111 330457..77 11RReeaasc2z4s e0i1s5 g1i6c3i0o0oz3e1s09700 11 32180097 F1OROGD4J6AZRE 10115% eOilescaeepszsreS e6n0 111 325705.68 FROeOsDeIaArK o11i5s Goliesreeneiezir esoa 141 e37r1s6 11RRGE4u6G22%5 0011SS eeiievseeoeniciezr esnO 11 321827..80 F1OROeD4IEA3R0 e1i1s5 eeiir7ziecseilaszi 2300 111 338213.23 1FOFUaDdIA3R1 1e1i5s e6i177d3c0e0i2s0e5 5700 111 325065.57 11kpaacgas:2 eeaiss eeiarpseesezizars 2eo0 11 332215.62 F1ORDGU4JEA3Ra 1G1155 eeii7rSe0e6z24ed2 e000111 234442 1FOFDeU4JEA3R5 0111S5 e0i178s6e0E8I3e5l5 7300 111 0313.573 1rRoesdeEa3?E eei1s5 eaiiseizeeecsziesz eSaa 11 321442..85 F1ORU0D4J6A3R6 101155 e0i1e83400e0336021 2800 111 336021.82 1FFOeO4DJ3A5R e1i1s5 oOi1s8s6e0oez3s5r8.300 111 23831336 1RG4540 015 016700280 30 1 280.2 FoODIAR 1n 503.1 002697 Son Ht Gah Lama Zi BESTCOPY AVAILABLE 002698 cphoronernsG1t4lsaasdeEsccNoonTsrs k3La4a prsictp er E SInEyLoff emeeeeneanktee 114 I m Fearmt rae aaenla 43L eISioeee uiofF SsGetemaeetrn is1 d34a iEPfeeEell si eSemleenne tise 1a4dee fLLeooeiiilhOnaifls aGrernreieesnnenens eaEfe l44 Eiiowee soEf eemreientnl fh1 Fi sancr heirf feaomomsnieEaentt 2J0O b4e BFdfuolietdclnieise eSOLiifffSSSaeecmtsmeeeeanEnntlyBu d4dfe A m icaoE fnsee Y en 4 Ra mernsarmaeneeerniny 41 ffoooitiee Le if uGeean et:aa b44s NmFooenRm NaEtSEmmeEnny ie M LEHroaaRsthGeos easosnereeceime E4S0h 53i m eTonra a omloemna eentne Lb HuReenseSfrf Gaaememenernhnefnf fpePaEpmgsSsetraaamcmweemnslb8LL ufm oelniena g1adomey nenesna :Soo HD ToEheGwla oamln Emnael!L FOOUIRR 155 e117eoits 50 1% wB2eis FmEeHi . i mEeie wE bre F2E5eH3 gi"eisel mmFseeei = E2H3 2Z2i11 2iB w3s =2 xii: BiEetHd 2EBee @FeH 5w=5l F2BSei1Hl 2nw1se =FHEoiHd 2322ss32 BEST COPY AVAILABLE =5BBli.e . 3735 1213 002699 iIPPa0i4isczes eBuSs o0a1i1s5e0e0z2r7a4 5E0 du8 FRiofOoG4uaZicInsTke aG1et5:%: ebelliiazimieeooizsretsd 2410 4S5in FiOFOaUdIsRiRe o1s5:5 Goiizoaiceeesrrsa 2s0r iS FFuUolSdnEk B1E5S GelasfsSsoosieess e 26 S15 FiiaFRoo@oiiizinaaks: pG1i52s: booliiizdsreeoooocazzoeesr 7a3000 5515 RFiaofninoiciaiesse 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BESTCOPY AVAILABLE - 1246 Luks Vb ORALCGIET) TGH-ONC STUDY OF FIi=39iEde& FCe-z1e4s3croIsNizRATS TTSoEEbCGH&LIBADiEAeTEIN3IFTEsIMrAAaLLaSEse5sTH S5E0THNuNGFEERFULL0-F3o4c0h, 0J-A3R3S8 e23GRANS seek 20 FFiroeedisosistntek 1Ge1is3fs 0oeaoarvvaee0o0ec3se1ers 118000 111% SPouie eis Gececeite So 4 aiesr1si des 5 HFNoRAmIiTTnESg G11F3 obaarnrrsseoebmncaztlerss seaunn 144% INH ED Gaewiz ee 4 E25r75as Hie oL EstNsTtRiUvBIeTWrSAevNtihvEeeSLC1R8 SRA 3 mewiae wn o1n 4 FaElee aa fFWoOUcEiSEBROED GMNleLwoEss E w Ea dw Woh 5 Sloss 0 4 eifrs Zhe 1 m LSweImnOliNaGLlLGl GSleiadi sm seesnssw n nia1 FEShroen Sena JPG itu E E DIrD OeNrERion Fis nif amass 30 11 a3So2ss& Fe F(ifoFodOsieConIs 1Be1Ia5Es oOmiiliaivteeeopesisieerez 1sz0uu 111 Lieaive eis eiiewds 1 E2Se2cs1z 37 Frootstiimee ifouses o11i5 ea: comraiszoeateeeseszseetr sreu sb iFRMST as eisecerse ov a1111 3E325e7s FA pLFraiesinstoees ro1i1f0eemiazzreaboeeeisezse 1av FUioee dis eisevorie au 1a1 11 oo3s2e1 Ho H LiFreciihdcoen: 6Go1iisfs oooiiizzsrseeebcweiaszaeesz gsrouo 11a1 DUNE 01% oisevozee do 1 3BEr5oE7 2051 iFirroebuaiociiemc:es IRs 0o11i1ss Gif eeei1iz3ds2oeesc0ss:eiise eizeaccer 7een0 01111 10 1 r5Se:ed BEST COPY AVAILABLE 271 opifauoavionee eo1i1s%loeiiez3eseeecHsaHsrze 8su 111 3Borsse 002733 1247 Fusidne Aeon das Bas wilde GuIsenze 3 Su 41 4 radmin 61s eldwsesls 20 1 332483: 31 2 . 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BF - 1258 BEST COPY AVAILABLE BEST COPY AVAILABLE 002745 1259 TW VERS GRALCUIETS TOR-UNG STUDY OF Fri-i3E2X4P.&#FC6-218413CROI6N1ZRATS TTEiLrAILEIFDERIIENSITI1A0L/S608S1 1H FSEuGFUNREAETRS 32 FDE3M4A6L,E0-338 WEIGHT OF FULL FOOL JH.S SZSGRRNS WEEK 22 I1FF3I44SSTTET F1OPOOUMISATEE 1EQFOOU4ITRTES 1REeRaanScEsn FToOnCiLtIeAE FSoEoItTiEe 3TFRAEATTE FJ lutter FTRoEnUdIEa 1LeE0UiGIEDn ELEGrviInGEe FTrOoOiaLe AFFEGAASSTL F1eO0SqCiIEAaF 1FOFDOOMITASFT 11RPReAaStSET: FFaAtCE 1FFoeodtseers FF1ORoAOaO4iIEoRGlED IiFasico0:: F1OFOGUaISRoFd iFOFOnUaJgAnEs R1ReGuAZseeE 6L1F3 BeO07iAiEaIiSeId 1186 11 1e1i5f GBeOraslleoiiTeEl s30a 411 O1I15F 0bi0rETlleGiZiFrE ESO 0111 Giiif 0boaocTe0lEeEiEi SSUi 14 G1o4h5 eeetreRiieEcIESrE T#uE 1A1 u4l0l5 ecileuliaieeiieees woeu 141 bEiDs GGeenidabeaieideoze 1 T ibe vibeaiidY s To A wcaaif posainirdaeweeess oovn 14d GaiEf iBietEiebesus bao 11 0113D3 vCairAdLaEtLiLiAe 0Si 3%41 011dP nGiAiLiMaDbLiTaeU eTnG 1Aa BO1M3E wGlLlLbEaAGDBIZEES B3UG 1L B1I1EF Geallisriaeciiaerd a706 111 B11I%E e0i1i2s0i2e0i3l5E6 ZZoo 111 CBLLFD BGlAZZlilmGiiiidT 0Te 11 1Bi0d5 eGliiidikiaerigiea sTuu 1ia G111%5 Gillietaieeisrese. ezCe 111 eB1aL1:E5 o0B1lLI22T9cL4aO6eI3iI6SS3e. 233000 11a1 6i1f5 eolli3iei1e0s2eErS 2600 11 1011:5 @6ii3zZ3i1e0i2T2e6 G70G 111 e1i1t% ee1a3i3ain0z3sEsr r8e0 111 Goiii: GGlliiiclienziazra 600 11 3Fa8s3..11 G37e0i.s1 2pr%t 6 2i8s4.s5 m35a5.s7 3zeae para z IGmoery7 ZFrse 3360s 4 3Errar.ed ssires 7 E2E08 Sae7d 71 33155622 333740s7 1ee67 z56ss 76 33356.05233BEST COPY AVAILABLE 2e5i5 2& 3E2O6).7 - zeirs a7 60 3a2r3e6 12 + 002746 BEST COPY AVAILABLE FiIFROPo0GoiLsnsIniAeeeEs 11101113:5 ieBiLadIsoEllLuoEiiIioEts. eaaiesoc feTuuH sw 111s 1 FPiFOohaNaniE:n Go0i1E:% Gvoiilaeiitdeeezsieiese 1s8o00 1111 FiSRoOeodcUiiiLeT 1oI i1l5 vGa lleivciim eesnrs f3o0 d10i FiioFFcanniaiccniiets oo1ii1s%s eoell1udsseeilioovsiioaere 2sS0ou 1111 Fiioffcnotisiceniikc e1oai1s: eeeaalssscaiitaeecssierirez resuao 1111 Fi[FFoaSaSoifiinct i0G1if3f ceeiiissseesiiieecsscecesss seaa0n a111 FUIhFioeniAriictslG waBiafdl bwbiiistihcdiaoeociieeires oS0eh0 d44u FFoeaNlleSt UoitEff aeGiiswogicenaonw Ea3nn0 14 FILRoeaianieii aLoiii:b acBiangdeinseeecittnhe ign 0411 FTiroioceiecaisms Lboafisf eGeavAseEseAalReeIncNiesE Bt16uu A44a PSREeaEiiRe Pcs EUoisiIewirGcsnaEicierNf4ob 01 4a SSLoioEoiiEal ueaiil: GwGiihiradaeenmsaeniefcoa 111 FfpOrorCeTeAeE egr 115 eazraesse 30 3i1 FRGorGoenaIitnSeE 1boi1il%s oewliicrreaaiddeevssesoedlr Sssoun i11b iiRRoaaecist:: Footimk 0o11iass: eowlileeesncaideevsierseetr sssuoo 1111 FiIoRfcooeegies:eh 4oei1if5s eeeliieeeseiidceensiissts rrkaoo a111 IRosiio olf oiericiis su 1 roooon u ai386z6.7 Sp35ea0y4 SEFeil5 3B6oa77s2 3Fz0e7s7 Sszeeee SHPeyie2 33wa5i4 SHEy SoFzeilse fHee7 ZH6oe: i5it4e Z#eesad e325e435 bwise FHFegdr is we. BESTCOPY AVAILABLE 002747 1261 BEST COPY AVAILABLE ve omer+ Tue STUY OF FHZuiLdie8wEbUrLeAak1e4rsBATS LprE Tt T 3 iUenise5: p1e0.n5e0ed a Fin TanOkeRr L3 b=Fionitd anes caverns ke 2 JSreiaatreir HEE WoiDs TI wpoadzdaevcosrse hemi svee 44 a4 oIiArNirImp RtuOiNabEeeNn 3 Wen mIamEa aw PaEE LE Jira NTIUINEARILN Ges aeiaeis w as w Lo 4dw ForVEO edit ATaEl Gs Lbmoetaegesre oipaless wwee Fins aus vasviodoh Fe 44 rientien SET wan: iBaereave ive UL wwHee E]0ae or i Seance BD Gieraecse iSorinaitnre (road baldes an GbaAsMdAaAwBiIiEeR iraeimd Im u 4A av Sierra:s ein fGna:n WI Swhailaiwaaisaen Mie dtuu a3d mde ew4 FP ToentE e LdaR sEAwiNiS iEdeRiwGs ae 4 R(SeraiiivrrreirnbGeieo vbliedsreieie mziwees DBen oto vie GagilbsEe ae 44 1 JGEEaRiCrIrTsE Teli 8oiFs Gf epaizzmbaivoczeide Gilcabdie Wie we 4A EJenNarTid GwaLs merbsrEtlbedeoiea8eh 4 fIeatEils FONE faafi TE bbaizdedroosiiice TEINS Gme d Rae reoagred eheoo ePaihshovess wr Se ve While ae phaamaartt waayn wGaalriimveedre B0e 44 Zzsev6 Si i wper3 rad rZeo a pS6r41 Z2s mGoEne ZSinaa Lis Sprea ESiea1 aSoilss= aZoos4 pShroe SLeEn HZeaorn SZiiz Zhe 8 BEST COPY ezi:s SZhiea Zs = Sprls 1262 3s 002748 J. 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A = in2etge . 09 ol . 200.7 12 002755 : Tr IFlila ees BSeheane ee 5 w30e6.:1 BESTCOPYYAlAAVlAILABBlLE Roe SMEAR BR FLWiEheTSSSiTaEaHnNEiESef8 GLneihmmogsRnTniOEREnEEmRniNlEnfoofb phu Theoonr eISa aaEEmNRNGl EnNIETT O3ffB n wmmrmeEEe TgSEEiEma NNdGEiLLL B3b epEwhelRie S stEEEA MERERRL REIEE 8Bb SGromnoiuarIpeMEEs mREEnLLdob CpLLoomEllinEGuRIIEeEaEEEmmEREEEErNRILELnfbob mp L EefRo em odeSr elaa matenddfL h LmETsu Y iBL e SE EeEaRd E nE Esalb mLmSeelhleREanEnEdEiRERnALLLfOB4Sb LmTE EEILEERNNLEES8 GoeTnerEEaRrE nLbf PPaele wEl GSitEe se Db wi =i1i i mEHErlsl H==EEoii oEusiiis EEi ErHH E: HHEBouye 5i mdi fi EMHiiH3 HHSaeidL HEel i1 H22l5 BESTCOPY AVAILABLE ETWmhSmaSnlaoEEmLeE AnI A 3k8 JiPenee 1270 002756 JOILONE SEEN GSGieeireentne a esen wde f3p6e8e.7 FiE a f [fniecmn tMEeEEreEeG aER:Y we S2Hou7ls - 354s mr fpsoeslonGIsNhREes NAGiEE ib w. xa i SFoie $s F fereelmo in r UwE GEeSln RreetLs 3 S3ei3 See fLreEi i SEN UBIDE IE GGEristnaiaonaoaens SShema 0stee en 816 8 3 EBret $f iE Sees sfBEkeGeinsimecsniaezae es1s sheer TI B3doEo5Ea i p paeerinfGninGcGEiEehNeeEnmmSsaeee 6e1ase RS#eEn7s 35 Cfpe raelinEGdE hGrlarenrrs ell ME SST en aean xe EEiE ee 3a LFfHhaenUrpEiENgEMreSHohmeaneeeiesiererrl1nae vsSU EHEieYs i pLSEnoIwLNSE iEGldleeEe Ervine he6 aeea faHiekel fr Ldeiwyan Then l0hml% LE MAMiIiiEneLesGrsIerwWee k1s mien ree eS$a5ts7 rod o IjrteewetiaiviinkagSSarhliveeit I BE Glia teeee bat e aFFe7aa Wr: Hm peerrb neGl Ma VE VMEiilmheienetsriiw ze eodes ENG a ke Bf2eEast Fri CEHhmeEsiinl 8E EEGS ltRmR eIrriEze oe le iEEd7 tFa Laetnieh neTakeamGtgaimieeemarrieaese n|e1s 3iHiii2 BEST COPY AVAILABLE 3a gmefoeinsinmtlsiibEUlddicRiihannyTeetaseae mEFLet i . 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RATE STu TE reekeesR rboorE sn FETE ERE sues sznomns eer 30 sfersairssee oan iscom rtsooee n s2aJ 4 Bm imE egmsnIe aEEs n Ed PgFoaOrie OifE e SSvaeem ennesesn d4de jHa aise dLEi GSeeene2 dde Ejloaeelr ShSiftaaeimeeneerrlans 3 3 efRoAirEe S if SaMloN mean Rfide1 EpTaeEnask hu heE ammeexEd2 ETaErEGblEaMeeSmnee Ed 5 pfaRnoTainNGlEiiSnteeieran nNhe4 HCpaOmnelNisEIMMaEmeReEnmIeEna 41Le oFf IOhRRErSihfEiMSaimedEg enmssic a 20 1 ile mfimaLTaE Mbeanenyl11 iTPawnss ulnfaaSstaeinmgteBn |3L LE omapnmes basEe seonamieienenndLi HEREhE S EEaE E meE Es 84L lTouere: EifueNaEsEeRSso 4OL 602784 n=1si 2 Fx3eH n2Geo2st e5E5dH: FFeiegs F58E ZaFHee &2333 E#g@oe3i 3Fir%s: =5 2o2:e 5Ha2e 2HaF2r+EsSBEST COPY AVAILABLE u#mueiiss 1298 m8 Zee FH RFftriTooreEse OoSruEisee UungRngGl esErS 43 3 HHmseEelsss fC FheoaiOrsa is SVIm EeShmuieirossrode4 a#x=3ese . 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TTEUCRHISIIAOCRTEINITI1A2L0S175501H SFCCLO0FMUREEIRSE& F0-E3R4A0L,E0-238 WEIGHT OF FULL FODL JRE S S2soRAns ner 32 hEanoi GF 0011R000405078E GG0S 0071108060 G0 OLaUtIe 01115s vGoovoaoopasseis 6e0d 4a1 RhoGrAneEd OG1i5f GbaOs7eAe0r0sAs7 3s6e 11 FIOtUERn 1G115 oe0ocnoooziiize ssoo 111 LFuSubidnle G10a5: oG6aceeoebaiieisc Bonn 411 UIRREGIEU:E GGiins UolloRi0nEeIa1zSs eBon 44 GIVaeiieie G1L0E% GlelszeoeoiieSde 2300 411 k PUGLG IRE G11LS Goaanodeeenezieidz Ton 111 WIaGllEs vwiilh oollooseospsisize z2o0 14 FAorunne AGl5s ewlieosSeasssziec 37b0 111 FIuroliinse w1i0s bGLlLGIOGOGSSEES S10 0111 UJWRiWiSsEtLn oGiEl GGLiIiTZeoRoIcIeEs 1100 41 FSoPuIbSieneC 1G113 OGLLLLSIGNOIZEAT 3300 111 IFPOGOAUSIENSe G11E5 GG1i1l7GReOeLiEeAa 2S0O 11 PJrSInEE GC1L5S GeLlISEeNs0iIiEsS 7200 11 FIOkUiLaIcRiEe 1G1U5T e0112:1800064S2I3L 0S0 61AL TPuhoivdeRsk G11155 oGllziceensiiieds 1s6o 111 LiRPeaaiineeEs G61S5 GoiLzBs0enIi1sEs 4so0 11 FLOpgGdCcIeRs B11055 0w1l2Z6r0e0c5i3a5s 4a0n 111 BIokOGUiIumel O11155 0G1lZzSE0e0w3iaoEr g0o 141 SIhiwinses 6w1i%: Geirsioibeoesiizrz gsoo 41 raRset 1G11:S G011332000c3hSca Ean0 41 G Founak G1125 GouIiTn0en0iziee 3sn0 411 UIwWioasne WGl5s aMIiTiTeonbiItiel S10 611 FWoiodsee 0115s eBiliiEmeiieess ftoo 111 NoOT ON STUDY easie a3r3s SSseee Fiee a36s3e6 ei8s432 2r4e.7 33:0223 MSrw 7 2355 4 EeEl E38e75 s32a4zs m673 pars 5a1s 1e5e4 ZZienaa o=irs BEST COPY AVAILABLE a3r:e i50nae pFrE -- fBrreen 1302 SEeEek 602788 Soi Fun GA Ls ealiE se oae 11 ISPhIeSeIdL lGs1 uellidZzeeusiiszse c6n0 11 FO0onlIdS BUISS OGLLRieeaIeoEI B6D0 141 Cwe eal wLlEl N macunE ita 2E0n 111 SWheEedIy OlLnE aoisiisWaisE 02 11 FTuroecainnlte G1015 GnULSI0O0UEeZsG ESD 111 FLUEOUlIlRM o1l1e5 BGISL1GIS8SE 2700 113 IIFPOIISZILEE G1I ODIITLGOG0OIIZIES S7H0 11 FIUOLELOZnOE B1L1E5 GGIliSeToEnOiZSEs BsOn 111 F1OFUOLIISRZE) L11S5 PPIlSESEGRENZEAST0 3200 411 IPRPEIILZiZI2 BG015 Geilceiwbnoociaasl S7o0 11 FLoiulndRae E10E5 BlLeEcIeWeGiEzS 0se 111 FIOPUE B11E3 GGlAGES0e0NSEIIEA aa0R 111 IIFGwIiSSEeT GBaAiS GollEg7deeOoiiEaln E1n6 11 AFPolIdEeCdE G1L1E3 WBldeOSM0N0IiTIZI 6Sn 411 FLLeOEUiRE w31a3 mDITTI0GEEIERS S2O0 111 frig Srinll GBulnn eOlLTioZo0eBzIzElE 030 11 rFOoOsUTsRie yLse r BITAe ETE GR 11 FJOiOlLte1d15 GoLlViPoBeRaZiEdL BlUn A4 LLeeaadisitS 0013S oniiTTEBOMNZIESER E30 011 faPoElIaERTee G1I0F7 BoLlEgLoGoGsIiSiIs 1700 111 FJiOniR? 10115F Gw1lzSi2e0n0c2eEeE I4n0 111 IThRwIIEEIiEE GGLAC pDIlSSIbO0OISIEEZ S0O 24 RIOhOOUaTEHaKD G10F5 oGlLeETE0B0OiGaLzE S10 011 FoopaAR n BwaE 4 izzeez . 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