Document jBegeQEGyvmw1oKyaQjQ6X4L9

FILE NAME: BF Goodrich (BFG) DATE: 0000 DOC#: BFG033 DOCUMENT DESCRIPTION: Book Excerpt 20 RUBBER CHEMISTRY ANC TECHNOLOGY r'32 L. D2'5O, r25a1nd(1I.05K2b).ssler, Ind. Chim. Belgique 16 (3), 133 (1051); R uhdek C iifm . T eciinol. *'M A. U1.)0A8 ll(i1s0o5n2)a.mi 1. .1. Stanley, dw d. Chem. 24, (>30 (1052), itinmKit C iikm. T eciinol. 25, *** A. T3k8n3c(a10n5d5)Y. . Kollo, Chem. Z vesti 7 (5 G), 257 (1053); IIuhheu C iiem. T eciinol. 28, 636 V. K(c1l0l5o.3a),nd A. Tkae, Chem. Zvesti 7 (7), 385 (1053); R ijhiikii C hem, T eciinol. 28, 008 MA. T2k8n,c0, 8V0. (K1c0l5lo5,).and J. Hiivikovn, Chem. Zrv&ti 8 ( I), 3 (1051 ) ; Knit unit ( hlKM. T eciinol. *37 V. K(1cl0l5o0a).nd A. Tknc, Chem. Lity 49, 1587 (1055); H uniisu C iibm. T eciinol. 29, 1266 s y K2e9i,|01|2A4.5T(k1n0c5,0m).ul J. Hrivikovn, Chem. Listtf 49, 1433 (1055) ; Rudiieii C iem. T eciinol. 664308 BF.. IAI.. DKoegnaddakllina,ndK.J.KMnsasnanto,cJh.kiPno, lyNm. eKr lSuruiz. c1u9,,a5n0d3 A(I.0S5mG)i.rnova, llcpt. -lew/. Sri. U SSR, 641 J, EP. hFyiesl.dS,cDr.. 1E2., GW1Goo(d1f9o4id8,);anRduiSjb. eDh. CGheehmm.aTn,ecJ.iinPoolly.m2e4r, 5S0r1i. (1150,5511). (1955). 642 E MN.eBwcvYilonrckq, u1n0,7i0n, "vTolhuemrme a1l, Sp.ta1b8i9li.ty/)! Polymers", K. T. Ccmloy, ed., M arcel Dekkcr, f6i4431 AA.. PP.. GGrraayy,, CAa. nI.I../C. aCllhcenmr,. a4n1d, 1F5.11H.(1C9.GE3)d.gecombe, Can. J. Chem. 41, 1502 (19G3). fi46 R. S(.7A),le0e4v,(1V0.0V8).. Zharkov, and A. P. Kafeugauz, Plast. Massy (7), 03 (1908); Son. Plast. 646 K. FTuejcimhnootol.a4t3u,l|8K00. W(10a7tu0y).a, J . Appl. Polym1er Sri. 13, 2513 (1009) ; IUiudeu Ciikm. 6f,447ti KF.. JIm. uLrinni,nHg. aEnnddoJ., aEn. d SMte .wTa urtk, e Jd . n , tHesu.i t . N Cath. v jBn.a rS.o cS. t aJ un dp . o n 6 03, 70, 8(7140 5( 18 0);0 4R) . u h m e h C hem. 648 F. J.T Leciniiinngo,l.Iv31J,. 7P1a9rk(s1,95a8n)d. J. K. Stew ait, J. lies. Nat. Hur. Stand. A 68, 409 (1904). 6r,6M0 JJ.. LE.. KStoeewniagr,t Man.dMF..[CJo. lLeminainn,g,J.J R. ,liSesh.eNltoant., nHuudr.jPS.taIIn.dS. t.a1rm71e,r,10Ru(1iu9i0e7h).C hem. T ecknol. 662 N. S4h4e,p7p1ar0d97an1d). G. II. B. M. Sutherland, Trans. Faraday Soc. 41, 201 (1945) ; R uhiieh 663 N. SChhepepma.rTd eacniidnoG.-. B1.9,B0.0M(1. 9S4u0t)h. erland, J . Chem. Soc. {London) 1099 (1947); R ubdei 8MA. SC. hKeumz.mTieucskiiini oaln,d21L, .79V9. (B19o4rk8n).vn. Zhur. Piikl. K him. 31. 048 (1958); Chem. Ahstr. f65 N. 5.2,K1la5x1i1z3cnb a(1n9d58B).. A. Dogadkin, Zttvodsk. Lait. 28, 438 (1902); Chem. Ahstr. 58, lG13c 656 L. O(,19B0a3t)e.man, l. W. Glazebronk, C. G. Moore, and R. \Y. Saville, Proc. T hird R ubber CTeiickhmn.olT. eCcoiinnfo. l(.L3o0n, d3o9n7),(1W95. 7I)l.elTcr and Sons, Ltd. London, 1954, p. 298 ; Ruuueu 067 R. WT.eGcilianzoclh.ro2o8k, a1n09d (I1t.95W5)..Saville, J . Chem. Soc. (London), 2U91 (1954) ; Ruhiieh C hem. 068 J. J.3S6h, i2p1m9an(19a0n3d).M . A. Golub, J . Polymer .Sri. 58, 1003 (1902) ; Ruhheu Ciikm. T eciinol. 068 J. la1y02n,sh5i3,1J.(1F9u0r0k)u; wCah,eman.dASb.stYr.a6m6a, slhIiGta4,GKItoh(u1n9s0h7i).Kagaku 23, 531 (lG); Polymer Hep. fiC0 K. V7.4,N7e7l'1s7o(nix, a(n1d97N1).. N. Novikova, Vysokamol. Socdin. A 13 (I), 140 (1971); Chem. Ahstr. 666U2 RR.. NO.. CJoruiselsc,i,PJu.reAmA]e>rp. l.OU('hCemA.cm1.8,*S3o0c.345(1,980198). (1908). ENVIRONMRUENBBTEARL IHNEDAULSTTHRYC,OPNATRRTOLII FOR THE W . E. M cC ormick Department op EnvihonAmeknrtoani,. OChoinotr4o4l3,18The II. I'\ (o<>imi<n Co., CONTENTS Page VII. Antioxidants and antiozonants...................................................................................... 628 1. Aldol--naphthylanune (Agerite Ilesiti).............................................................. 628 2. Alkylated phenols....................................................................................... . . . 628 3. N,N'-b2.s(l/E(limclIiylpcntyl)-p-pl]eiiylene(liamiiie (Eastozone 33). 628 4. N,N'-6is(l-etliyl-3-methylpentyl)-p-plienylene<lianiine (UOP88). .. . 628 5. N,N'-i>!'s(l-methy!heptyl)-p-plicnylene(lirniiie (UOP 288)......................... 626 6. G-leri-Uulyl-i-cresol and sidfur dichloride reaction product (Santo while M K )................................................................................................................................ 629 7. N-Sfc-liiityl-N'-phenyl-p-phcnylenediamine (Elexznne 51,)......................... 629 8. N-Butyl-p-aminophenol (Tenainene 1)............................................................ 629 9. 4,4'-Butylidene-l>is(6-ieri-butyl-m-cresol) (Santowliite l'owder)............... 626 10. Catechol (pyroeateeliol; l,2-dihydroxyl>enzene).............................................. 630 11. llutylated-octylated phenols (Wingstay T )...................................................... 630 12. N-Cyclohexyl-N'-phenyl-p-plienylenediainine (Flcxzone 611).................... 630 13. 4,4'-DiaminodiphenyImethane (Tonox).............................................................. 630 14. 2,5-DWeri-amylhydroquinone (Santovar A ).................................................... 630 15. NjN'-Di-ji-naphthyl-p-phenylenediamine (Agerite White).......................... 630 16. 2,6-l)i-iert-butyl-a-<limelhylainino-p-ciesol (Antioxidant 703).................. 630 17. 2,6-Di-ieri-butyl-p-cresol (butylated bydroxytoluene, B U T )..................... 631 18. NjN'-Di-sec-butyl-p-phenylenediamine (Tenainene 2).................... 631 19. l^-Dihydro^^I-trimetliyl-b-ethoxyquinorme (Sanlodex AW ), . 631 20. l,2-Diliydro-2,2,4-triinethyl-0-doderyl<puuolme (Snnloflex 1)1))... 631 21. l,2-Dihydm-2,2,4-t.riinclbyl<juinoline, polymerized (Agerile Hesiu 1), Flectol II)..................................................................................................................... 631 22. Diphenylamine-acetone resin (Aniinox, Agerite Superflex, BEE, BbE-25) 631 23. Diphenylamine-acetone-formaldehyde resin (BXA-C)................................. 631 24. N,N'-Diphenyl-p-pheiiylenediammc (Agerite DI'PI), JZF)... . 632 25. Ilydroqiiinone (Tecquiuol)........................................................................ 632 26. p-Isopropoxy-diphenylamine (Agerile ISO).................................................... 632 27. N Isopropyl-N'-phenyl-p-plienylenedinnnno (Flexzone 3C, Santoflex 30) 6,33 28. 2(2'-Mctliylene-ins(4-ethyl-6-6Ti-butylphen<>l) (Antioxidant 425)............. 633 29. 2,2'-Methylene-6is(4-methyl-6-nonylphenol) (Nauga White)..................... 633 30. 2,2'-Metliyleue-6!s(4-inethyl-0-/<T/-butylphenol) (Antioxidant 2216) . 033 31. Ilydroqiiinone mouobenzyl el her (Agerile A lb a )........................ 633 32. Monooctyl and dioolyldiphenylnininr (Agerile, Slalilc, Agerile Slalile S, Oetainino) .......................................... ...................... ............. 631 33. Nickel dilmtyldilhiocarlmmate (NHC).......................................................... 631 34. Bhenyl-o-implitbylamine (Zeozonc A )................................................................ 631 627 628 RUBBER CHEMISTRY AND TECHNOLOGY 8856.. IP'lhieennyyll--(0?--ininapplhitthyyIihIiammiiiiiiee-(nAcegteorniteerPesoiwnde(Hr,etZaenoozxonSepDec)ia..l.)............................................. 663854 8378.. SPtoylryeanlkaytelpdoplyhpehneonlsol(W(AignegrsittaeySSu,pAerfelirtiet)e..S..p...a..r.)................................................................................ 663355 4309.. SBtnetayrloaytle-dp--satmyrinenoaptheednoplhe(Snuoclson(oWxin1g8s)t.a..y...V...).......................................................................................... 663355 4412.. 44,,44''--TTlhiiioo--ft>iws((6d-ii-esreic--baumtyyll-pmh-ecnroels)ol)(Sa(nStaonwtoliwitleiitLe).C...r.y..s..t.a..l.s..)........................................... 663355 4443.. 4N,4-P'-lTieliniyol--6Nfs'(-6(p-i-etroil-ubeuntyels-uol-fcorieisyol)l)-p-(pEhtehnyylleAnendtiioaxmidhaient(A73r6a)n.o..x..)........................... 663366 4456.. T1,r3i,(rm>-iTxerdimmetohnylo-2a,4n,d6-dIriniso(n3,y5l-pdhi-eincyril-)bpuhtoyslp-4h-iltiyed(rPooxlyybgennrzdy)l.)..b..e.n..z..e..n..e....... 636 (Antioxidant 330)....................................................................................... 636 VII. ANTIOXIDANTS AND ANTIOZONANTS agoT1.hPisarits tIhdeeIanlstt wofitha ttwhoe-phaeartlthprceosnentrtoaltiornel,atthinegfitrostphoalyvminegramppaenaurfeadctauryienagr, apnroticoexsisdinagntcshaenmdicaanlsti,oaznondaanctsc.elWerahtiolersa.nPaatrttemIIptishacsonbfeinenedmtaodae tdoisrceuvsiseiwonthoef okxniodwanntstoaxnidcoalnotgiyozoannadnths,anthdelirnegunexdpoeurbietendcley ohfavtehebeecnominmadervceiratlelyn-tuosemdissainontis from1. thAeldloisl--t. a-naphthylamine (Agerile Resin).--This compound has received cwleitahrarnecpeeabtyedthfeooUd. cSo.nFtoaoctd2.and Drug Adniinistration for use in rubber articles chem2.icAallksytlrautcetdurpeheannodlsn2.o--t Tothhiesriwsisae gcrlaosuspifieodf ifnoutrhiasnptrioexseidnatanttisono:f Nunevspaestcaifiinc A, NNeevvaassttaaiinn BA, hCaysaannoxorLalF,LaDn5dofSoarnrtaotws loifite1.754g./kg, while that for Nevastain oBf 2is.4a7pgp/rkogx,imaadteerlmy a2l0LgD/k50gfso.rCthyeanroaxt oLfF> p5o0sgse/kssge,saannd oardalerLmDal60LfDors0tfhoer trhaet rLaFbbaint dinSeaxncteosws loiifte125.64 gsh/kogw5e.dEyaesilrigrhittattioonnsetguadtiievse, eufsfiencgt rwahbebnitsi,nostfilCleydanuonx diluNteodneintoof rtahbesbeitsa'netyioexs4id'6a. nts presents any unusual handling requirements. The3.paNs,tNh'-isBtoisr(yl,4o-fduimsaegtehyhlapsenbteyeln)-pq-upihteenfyalveonreadbialem. ine (Easlozone S3).--Ex wpeitrhimseinntgalle sotruadliedsosbeys othf e E 1.0 agst/mkgananKdodWaikth Cs oin.6g l se h oinwtratphearti torantosalardeoskeislleodf 0le.v8egls/kogf, 0w.8hilge/ksigmialnard r0o.u4tegs/kogf ,adrmesipneicsttirvaetliyo.n Dfoeratmhsicewperreodduecleadyedde,atuhps atot t2w4ehlvoeurdacyosn.taScotmoef s0l.i1g-h5t inrirli/tkagtioonf tthoethuendsikluintedof pgruoidnueact,pibgustotchceurreredwaws intho ewvaids eonbcseerovfeds.ystemic effects. Some slight sensitizing effect to guinea pig skin andTahcetsuealdautsae ionfdticbacteconmopsoeurniodusovaecrutae nhuemalbtherporfobyleeamrss shhaosucldonbfiermeexdpetchteisd. Skin4.coAnr,tXa'c-tBsihs{otu-cldlhybte-3m-ninuitmhyizlpedcn. tyt)-p-phvnylcned\mninc (UOB 88).--The pHrOodPucCt.heTmhiecsael sChoomwpathnayt hitashacsararniedoroaul tLDv.a-,roiofours rtaotxsicooflo2g4i0ca0l mstgu/dkigesanond aitns HEALTH CONTROL 629 1L8lt0y0o mofg9/k00g mangd/kagn. ILtsDopeorfcu4t5anneoigu/skgto. xAicciutytefoinrhraalbabtiiotns sshtouwdeieds, aunsiLnDg Sr0aotsf eafnfdectgsuiantea30pipgpsmanfdorusriantgs eaxnpdos3u7r,5espopfmatofomrizgeudinUeaOpPig8s8. Aforsi1mliil,arsheoxwpeodsunreo atifztaertioan71. wDereakpewraiatinndg Jpoehrinosdonsh8ohwaevde nfoedfutrhthisercoefmfepcotsu,nidnctloudipnrgegannayntsernastis 0o.v4e%r a. nMaaprpkreodxirmetaatredlyat2io-mn oonfthgrpowertihodoacctudrireetdarayt lethveelshiogfh0e.s0t2l5e%ve,l.0N.1o%e,fafencdt ionnterremperdoidautcetiloevnelw, aaslthoobusgehrvtehde aretsuthltes wloewreesntotleevnetli,reatnydclepaerr.haHpisstonpoatthaotlotghye for aRllepleevaetlsinwsualst npeagtachtivtee.sts using 50 humans (application of the test product cwoams pmouandde twoasthneotsaamperismitaeryforirraita2n4thbupteraiosdenesviteirzyero. tShiemr ildaary)tessthso,wuesdingthae srhuobwbeerd cnoompproimunadry ciorrnittaaitnioinngan3dpnaortssenosfitiUzaOtPion878. per 100 parts of rubber, favoTrhaebler.ubItbesrhoiunlddusbteryr'esgaexrdpeedrieanscea sinkinthseenussiteizoefr tahnids sckoimnpcoounntdacht asshobueledn, ther5e.foNre,N, b'-eBpi8re(lv-emnettehdy.lheplyl)-p-phenylenediamine (UOP 288).--Draper and J0.o4h%nsofnorhtawvoe fmedonfothusr8.diAedtavreyrsleeveeflfsecttos porneggnraonwtthrartsatrea,nagsinwgeflrloams 0li.t0t0e5r%sizteo, hwiesrtoepoabtsheorlvoegdicaaltly0,.1w%ereanodbse0r.4v%ed.. No other adverse effects, either grossly or M K6)..--ff-Ttehrils-Batdnytli-omxi-dcraenstolisaanddasruklfluiqrudidichwloitrhidenoresapcetcioifnic pcrhoedmucictal(Ssatrnutocutuihriete. tTohxeicomloagniucfaalcsttuurderie, sT5.hTehMesoenisnadnictoatCe oamn poaranly,LhDa6s0 fpoerrftohremreadt osofm17e.5prge/lkimg.inTahrye amimniomdearlastiengalme oleutnhtalofdosksein, wirhreitnataiopnplrieedsutlotedth. eInskuinndoiflurtaebdbiftosr,mwiatsis>d1e0fingi/tkelgy; abny heyeeatiirnrgitaitntt.o R12a0ts hCavweitbheeonnleyxsploigshedt nfoarsaalnir8rithatpioerniordestuoltvinagp.ors generated the Ienyeu.sIinf gactchidisenptraoldcuocnt,taccatreshsohuolduldocbcuer,tapkreonmtpot pwraesvheinntg afonryaenmtrinainmceumintoof S15kinmicnonwtaitcht swhaotuelrd sbheoualvdoidbeedd.one and then prompt referral to a physician. repo7r.teNd-seexcp-Beruimtyle-nNt'a-lphtoexniyclo-lpo-gpyh.enItyliesnkendoiawmnintoe b(eFlaexszkoinnese5nLs)it.--izeTrhweriteh issomnoe indi8v.idNu-aBlsu.tyH-pa-nadmliinngopehxepneorlien(cTeenianmtehnee rIu)b.--beTrhiendTuesntrnyeshseaes bEeaesntmfaanvorCaobmle. gpuainnyeahpaisgs.obTsheersveedsamane sLtuDd50iesofin>di5camtedl/kagmboydepreartceudtaengreeoeusofasbksionrpirtrioitnatiwoint9h. proTcehdiusrecsominpionudnudstriys srheocuogldnizheeddeassignaedpottoenptriaelvesnktinskiinrrritiamnftinafn. d hnndling Mo9n.sa4ntt4o'-BCuolmylpidaennye-hhaiss(o6b-lseerrt-vbeiddyal-nma-ccruetseolo)ral,(Smainntiomuiuhmiteleth1a`olwddotsre)-f.--or Trahtes nofo1s7iggn/ks go.fRtaotxsichiatyv.e Dbeeernmfaetdoldoigeitcsaclosnttuadinieinsgp5e0r0foprmpmedfoorn90hudmayasnanvdolsuhnotweeerds indicate that this compound is not a primary irritant nor a sensitizer5. specTiahlehhainsdtolirnyg opfreucsaeutiinontshearerunbebeedredin. dustry has been quite favorable. No 630 RUBBER CHEMISTRY AND TECHNOLOGY pou1n0d. lCiaastecchoonlsi(dpeyrraobclaelectohxoilc;o1lo,2g-idciahlydbraocxkt/gbreonuznende11)..--ItTs hpisrinolcdipachl eemffieccatl icsomon tuhpeonceanntrimalalnedravtoau, sissyhsitgehmer, tlhikaen pphheennool.l. HTohweeavperp,roitxsimaactueteactuotxeiclietyth, albaosreadl dguosineseafopriga, n0i.m16algs/kagre12:. dog, 0.13 g/kg; cat, 0.1 g/kg; rabbit, 0.2 g/kg; and porItetdi1s2. rIenagdeilnyeraabl,sotrhbeedindthurstoruiaglhexthpeersieknince ainndussiknign ciartreictahtoiolnhahsabseebneegnoorde. pHroewveenvteri,nhitaslathiaoznaradnsd smkuinstexbpeosruerceosg.nized and appropriate steps taken to Rub1b1e.rBuCtoymlatpeadn-oyctyhlaastcdpeprhfoernmolesd (eWxpinegrsimtayentTal).--toTxihceoloGgoyodwyietahr tThiisre coamnd pofoubnodd1y3. wReaitgshht afovre abepenerifoedd ofifve36diweteaerkys.leGvreolsw, trhanwgainsgsifgrnoimfic5anttoly50d0epmregs/skedg aptrotthheromtwboinhtiigmheesstofletvheelsbl(o1o5d8waenrde e5x0t0endinegd/.kAg)t. bAotlhso,levtheles,cloivaegrulcahtoiolenstearnodl Iwnacsreealseevdatmedo,rtaanldityfaotctcyurcrhedanignesthwe emrealseesenat itnhethheiglhiveesrt laetvetlh. e highest level. everO, rtahleddaatataodfothinisdiscoartteatrheatditfhfiicsulmt attoereixatlriaspnoolattehigtohliyndtouxsticr.iaTl huesrees.aHreowno repo1r2t.edN-cCasyecsloohfeixllyle-Nffe'-cpthsefnroylm-p-iptsheunseyleinneidnidaumsitnrye. (Flexzone 6II)2.--Experi fmorenrtaatls toofxi>co2l0o0gy0 cmargr/kiegd. oTuhtisbCy oUmnpiraonyyala,lsIoncr.e1p0osrhtoswtshaatnitacisutae sokrinal sLenDs6io ptihzeern,ylpenaerdtiicaumlairnley. to those individuals who arc already sensitized to any Sk13in. 1co,4n't-aDcitamshionuolddipbheenayvlomidetehda.ne (Tonox)2.--The manufacturer of this dpireotdauryct,leUvenliroofy0a.l1, %In10c..,Spheacsifipcerdfeotramilsedof2-tyhre sfetueddiyngarsetundoitesavwaiiltahblrea,tsexactepat athsattoxthicereeffewcatss naoreecvoidnecnercneeodf, asneeymcsartcoinboegetnheiciltiyv.erT. hCearperismhaoruyldtabregetta,kseonfainr ahtaneldelvinagtedthitsemmpaetreartiaulreisn, ionfdtuhsetrviaalpoursse.s to avoid inhalation of the dust or, if stud1i4e.s,2u,5s-iDngi-tbeortt-hamraytlhsyadnrdoqruaibnbonites, sh(Soawnttohvaatr th.el)o2.r--alELxDpe50rimforenbtoatlh aspneimcieasl oisf t>h2e0d0i0etm) wg/ikthg.nRo aatdsvherasveeebffeeecntsf6e.d 35 m;g per day for 175 days (1800 ppm hadTnhoe pmroabnluefmactwuirtehrcoufsttohme eprrsoduusicntg, Tthhise pMroodnusacnt tooveCrommapnaynyy,earerps5o.rts it has von15I.lnNam,N'r-Depio-(r3t-naaplohwthydle-gpr-peeheonfylaecnuctdeiaomrainlcto(xAigceitryiteinWrhaittes,).--4.5Mga/lklegtteasanadn LtizDin60g. eTfhfeecstewshaemneaapuptlhieodrstoretphoertsekdinaosflihguhmtlyanisr1r4.itOattihnegr adnodt taaustolilgohgtylystsuedniseis cparrimrieadryoiurtribtayntt,hbeurtenpoeattainsesnusltititzeecrhnoriqauedeopnighmuemnatinnsg haagveents1h5.own it to be a no s'Eigllnisifaicnatniotxpidhaynsitohloagsicbaelenpruosbeldemfosr. mBeacnayusyeeaorfs iitns tshkeinruibrrbietranint deuffsetcrty, wskitihn cont1a6c.t 2s,hGou-Dldi-tbcerla-bvuotiydle-ad-.dimcthylumino-p-cresol (.1 ntioxidant 703).--The only available toxicology on this compound is a reported oral LD.-,o (presumably HEALTH CONTROL 631 ftoorxirca. tTs)heorfe 1a0r3e0nomkgn/kogw1n6. rTehpiosrtvedalueeasewsooufldillinedffieccattse inthiatst uitsei.s not severely of t1h7e. m2,o6s-tDwi-ilderetl-ybuulsyel-dp-fcoroedsolan(btiuotxyliadtaendths;ydirtosxyulsoeluiennet,heBIrIuTb)b2e.--r iTnhdiussitsryonies lLimDibtoefdo.r Itthehraast biseernepostruteddietdo ebxete1n.7s-i1v.e9l7y gw/kitgh bryesDpeecicthtmoantonxiacnodlocgoyw. oArnkeorsr1a7l. sTigwnoi-fyiceaanrt ffeineddiinnggssatut ddiaeislywditihetarraytsl,evbeylsthofes0e.2s,a0m.5e, oinrv0e.s8t%igators, showed no andM"amlloedtteeraatned" vtoon"sIlliagahmt"14sfkoiunndirraitcaonntsiedfefercatbslytohhiguhmeranLsD. r,ofor rats (8 g/kg) irritTahtiinsgcotmo ptohuendsk, inwhwileithof parololowngoerddecroonftatcotx.icHitaynodrlainllgy,pmroacyedbueressomsheowuhldat, ther1e8f.orNe,,Nb'e-Ddie-ssiegcn-ebduttyol-pp-rpehveennytlethniesd.iamine (Tenamene 2).--The manufac tfuorrerratosf otfh2e00p-r4o0d0ucmt, gT/kegnnaensdseea EpearsctumtaanneoCuosmLpDan50y,forregpuorintseaanpigosraolf L5-11)M0 mintlo/kgth9.e Mraobdbeirta'steelyye.seIvterise setyreondgalymairgreitaatlsinogotcocutrhreedskwinithanddiriescta insesntisliltaitzieorn. wPrhoepreervehranitdilsinugsecdo.ntrols should be established to prevent skin and eye contact acut1e9.or1a,2l -LDDihbyodfroor-2r,a2t,s4-hlraims ebteheynl-6fo-eutnhdoxtyoqubieno80li0nemg(/Skagn. loRfaletxs haAvWe b)2e.e--nTfhede dnaegilaytidviee.taRryablbeviteslshcaovnetabieneinngex0p.2o%sedanfodr02.40%h, foovre2r0a0 d3adyasy; apllerpioadth, otologvyapwoarss gOennleyrarteesdpirbaytodryrodpipsicnogmtfhoret parnoddumctildonlatoeryammateitoanl sruersfuultceed.heTawteednttyo w3o2r5keFrs. ohxaivdeanptawrteicreipwatoerdn fionr faivuesdeaytessat wweheekrefobrysirxuwbbeeerksg. lNovoesskicnonirtraiitnaitniogn trheissulatendti6. the Thhisitsoarnytoiofxtihdiasnutsheahsabsebeneenusfeadvoforrabmlea.ny years in the rubber industry, and acu2te0.or1a,2l-Dmiihnyimdraol-2l,e2t,h4-atlridmoestehyflo-6r-droadtsechyla<s]ubieneonlinfeound(Staontbojelcixn exDce!)s)s2.o--f A40n sgk/king,aannddeayne aircruitteatsikonin omccinuirmreadl lteothtahledorsaebbfoitrs rwabhbeintsttroeabteed>w10ithg/tkhge. cMomild pBoausendd6u. pTohneraenihmaavle dbaetean, nitoisrepprourdteedntiltloefkfeeecpts iftroomff tthhee suksien oafntdhitsopprroedvuecntt. con2ta1c.t1w,2i-tDh ithhyedreoy-e2s,.2,4-lrinielhrylquinoline, polymerized (Agerite Resin D, F2legc/tkolg.IIA).p--plTichaetiolnethtaol tshiengslkeindoosfe rtaobbriatbs bpitrsodhuacsedbeneon sfiogunnsdoftoirrbietataibonou15t. rHaotsdgfoera2nydreaonwdorhkaevres1o8bhsearvveedfectihdeafiolyrmdaietitoanryofletvuemlsorosf i0n.0s1o,m0e.1o,fatnhde a1n.5im%altso. 0S.i0m3i,laarndstu0.d1i5e%s wpitrhodduocgesd fnoor taum1-oyresa.r period at daily dietary levels of 0.008, dusTtrhyiswaitnhtinooxirdeapnotrtheadscbaeseens oufsieldl effoferctas.great many years in the rubber in 25)i2.--2. TDhiipshernesyilnaomuisnep-arcoedtuoncte hraessinno(.1spmeicnifoirc, Agerite Superflex, BLR, BLRchemical structure. No experi tmheannta3l0 tyoexaircso'lougsye hhaass bbeeeennenretiproerlytefda;vohroawbelev.er, the experience during more 23. Diphcnylaminc-acetone-formaldchydc resin (BXA-G)2.--This resin has 632 RUBBER CHEMISTRY AND TECHNOLOGY dmaotasp. eHciofwicevchere,miitclailasstbreuecntuursee;dtihnertehearreubnboerreinpdourtsetdryefxopremrimaneyntyaelartosxaincdolotghye hist2o4r.y Nof,Nth'-iDs iupsheeinsyqleuniteedifaamvoinraeble(A. gerite DPPD, JZF)2.--This old anti oeaxridlyan1t95h0a'ss,bietenwasstufdoiuenddqtuoitehaevxetednissitvinelcyt waditvhanrteaspgeecst wtohetnoxuisceodloginy.pIonultthrye afenedd twoaspruesveedntotnhea occocmurmreenrcciealofbtahseisseforriouthsispopuultrrpyosdei.seHasoew, eevnecre,pobbasloemrvaaltaisoinas, rbaytsO(saerleinngt1h9e5Gni1n9,gsohfowthienggeasntaatidovnerpseerieofdfewctitUhpsounbstehqeupeanrttuinrcirtieoanseodf mproergtanlaintyt tmoarbkoetht ftohrethmisotphuerrpaonsed. Tthheisliwttoerrk), hraesqubiereend ctohnefirrmemedovianl uonf pDuPblPisDhedfrosmtudtihees by The 15. F. Goodrich Company15. degrEexecoefpttoxfoircittyh.eWpheecnulifaedr aesffeac2t0%on apqauretouuristisounspoefnsrioants,toDrPatPs,I)thheams ianimloawl dleotshaaglesionfgl1e.4dgos/ke gistoinreaxbcbeistss oofve1r0ag/5k-g6. wFeuerkthepremrioodre,, nwohseingnfsedofaitllnaesdsaiolyr iinnteRrhfeerseunscemownitkheynsoramt alelvgerlsowofth1,ra2t0e, wanads o4b00sermvged/k15g. Openredyaeyarshfoeewdeidngnsotutodxieics effects and no significant histological findings20. posiPtiavtecheftfeescttss cwohnednuctteesdtedonw9i1thhuam48anhs, cuosnintagctc.omNmo esrecniasiltiDviPtyPDre,aschtioownedwenroe found when tested on the same personnel after a two week waiting period15. straUtesde oitfsthfrieseadnomtioxfirdoamntainnythseignruifbicbaenrtinhdaunsdtrliyngforprmobalnemy .yeNaros shpaescidaelmporne caut2i5o.nsIlayrderonqeueidneodn.e (Tecquinol).--Acutely, hydroquinone is somewhat more atoqxuiecouthsasnolupthioennsol.haTshbeeeanpprreopxoirmteadtetolebthea0l .2orga/lkgdofsoer otfhethriasbbciotm21paonudnd0.0i8n dge/kmgonfostrrattheed caat2r2e.laHtiovweelyverlo,wexdpeegrriemeenotfalchsrtoundiicestoinxicaintyim. aTlsheancdommpeonunhdavies capable of causing skin irritation from prolonged repeated contact0. dailSyteerxnpeorsuarnedtnashsoycdiraotqesuinhoanvee, rte.cp.,orttheed doenvetlhoepmmeanjtorofhbarzoawrdnisahrisdinisgcoflororma dtieocnreoafseedyevtisisusaule a(ccuoirtnye.aAalnsdo, cdoinrjeucnt cetiyvea)c23o.nTtahcetsemeayye crhesaunlgtesinmsaeyvelreeadeyteo irritPartieocna.utSioynstsemshiocueldffebcetstafrkoemn iinndtuhsetrihaalnedxlpinogsuorfe hhyadvreoqnuoitnobneeentoobpsreervveendt. iftosr eanmtrainnicmeuimntoofth1e5 emyien. wIfitthhiws ashteoruilsd noeccceusrsaarcyc,idanendtathlliys, fiomllmoweeddiatbey wparsohminpgt refe2rr0a.l pt-oIsaopprhoypsoixciyadnip. hAenTylLaVmionfe.2 (mAgg/emrit3ehaIsSObe)e2.n--eTsthaeblimshinedim24a.l lethal oral daodsmeinfoirsteriaetds ims a<ll1y0tog/rkagbbaintsdafto. ra rdaobsbeitosf <1.74 gg//kkgg., T5hdisaycsompeprouwnedekh,aosvbeerena s5u-0ltedweienk thpeerfioirds1t*.3 Nwoeetkosxiocf ethffeecetxspoecrcimurernetd., Tahltihsowugash bseolmieveedwetioghbte lcoassusreed bbeyenthemaaninimtaianlse'dreinjecctoinontacotf fwoiotdh asktitnhiosf hriagbhbditossaatgealleevveell. Tofhe1.5cogm/kpgoufnodr 4hahs apnedr dtahye,re5 wdaeryes npoersiwgenesk,ofovsekrinai5rri0tawtieoenk15p.eriod. No signs of toxicity occurred, Routine 48 patch tests have beam conducted on 91 adults with a challenge HEALTH CONTROL 633 athpeplcicoamtipoonunmdadtoe baet tnheeithenerd aofparim2 awreyekirrwitaaintitnngopreariosedn. sTithizeesre16s.tudies showed comTphleisteclyomfapvoournadbleharsesbueletsn. uNsoedspfoecriaml ahnayndyleianrgs pinrecthaeutriounbsbearreinndeuesdterdy. with --A2n7.acNu-tIesooprraolpyLlD-Nso'-pfohrenryalt-sp-opfh7e2n0ylemnged/kiagmiisnere(pFolretxezdo.neHSuCm,aSnanploaftlcehx tSeOs)t2s. tpaeirnfionrgmethde wcoitmhptohuendcoamspaonunandtiionxicdoanncte,nsthroawtedit ftoormbe, aasskwinellseanssirtiuzbebre10r. con admTinhiestMeroendsaasntao 1C0o%mpsuasnpyenhsaisondeitnermmeintheydl acnellaucluotsee,otroalbLeD166020formrga/tks,g.wThhene asucsupteenmsioinniminalmleetthhayll dcoelsleulobsye,skfoinr raabbsobritpstiiosn,>7w5h0e0n madgm/kingi.stTerheids caosmapo5u0n%d pthreoveeydestoofbreabmbiiltds6y. irritating to the skin of rabbits and slightly irritating to servAedppirnopanriyatiendhuasntrdilainl guspesr.ecausions to prevent skin contact should be ob com2p8o.uSn,dS'-iMs eplrhaycletnicea-lblyis(4n-oenth-tyolx-6ic-lefrrto-bmutyalnphaecnuotl)e o(rAanltisotxainddapnot inJtt2.F>A)2n.--LTDhsios Sfoirngrlaetsd, owsehsenofad1m, 4in, iastnedre8d ga/skagn haaqvueeobuesensusappepnliseidont,oistihneesxkcienssooffr1a5bbgmits/kagn4d. ktheeprte inwacsonntoacetvwidiethnciet ofofrsk18inh.irrNitoatsiiognnsboefyosnydsteamimciltdoxriecditnyesosccautrrtehde, atwndo ihnigthheesteydeossaogferalebvbeiltss., Wonhlyena tmhrilede imnfillalimgrmamatsoroyf rtehaectdiorny opcocwudrreerdw. eRraetsplhaacevde pbeereinodf.edNodasiilgynidfiiceatnatrysiglenvseolsf toofxi1c0it0y, w10e0re0,foaunndd,1a0l,t0h0o0ugphpmtheovrearts are5ceiwveinekg the Thhigisheasnt tlieovxeildashnotwheads mbaereknedusreedtairndatthioenroufbbgerrowinthd4u.stry for u number of year2s9.wSit,hS'-nMoertehpyolernteed-biins(s4t-amnceelhsyol-f6i-lnloenffyelcpthse.nol) (Nauga While)2.--An acute oferdalatLaDsleovfeolrofra5t%s ooff t3h2e.7dagi/lykgdiehtatso braeetsnforrep9o0rdteady.sTwhiethcnoomspigounnsdofhtaosxibcieteyn, epirtihmerargyroirsrsilytanotr oart snkeicnrospesnys.itSiztuerd1i0e.sItwihthasrabbeebnitsusineddicwatiethothuatt aintyisknnootwna pro3b0le.mSs,Sin'-Mtheethryulebnbee-rbiisn(d4u-msterlyhyflo-r6-alenrlu-bmvblyelrphoefnyoel)ars.(Antioxidant SS46)2.-- Cthoisnsaidnetiroaxbildeawnto.rkIthhaass baeelonwdelevvoetledoftaocautsetuodrayl otof xtihceityp,hbyseiionlgogaibcaolveeff5ecgt/skgo,f owfhreanbabditms ionfis0t.e4regd/kags aasnaaq10u%eoussolsuutsiopnenisnioWn etsosomnicoei.l aRnedpehaetlddoinsecsotnotathcte wskitihn tthioenssksihnowfoerdapnoprsoigxnims aotfeslyyst1e8mhiocutrosxoicnitayl4te;rhnoawteevdear,ysthfeorreawteorteasleovfer6eadpepglriceeas onfosakpinpriercriiatabtlieond.eAgre1e%ofsoilrurtiitoantioinn oinil,tahnedeaysesanofoirla-wbbaittesr. eOmruallsifoened, ipnrgosduhcaevde wbeeeenk mpaerdieodt.o Nraotssaigtndsaiolfy tdoixeitcairtyy loecvceulsrroefd,20e0x,ce1p00t0s,oamned r5e0t0a0rdpaptmionfoirnath1e3 growTthhisoafnmtioaxleidraantst haatstahelohwigdheegsrteefeoefdtionxgicleitvyela4n. d requires no special handling pro3ce1d. uHreysdrionquiinndounsetrmiaolnoubsee.nzyl ether (Agerile Alba)2.--This old rubber anti oxidant is a well-recognized dcpignicntiug agent. Its ability to produce louko- 03-1 nunnER CHEMISTRY AND TECHNOLOGY dboynKnalawudaesrf2i6rsatnedstoatbhleisrhiendvebsytigMatcoNras.llyB2l5aannkdalniads Msinilcleerb27eeanndweGllasuul2b8shtaanvteiaatlesdo afosutnhde ivtirtgoinbecoimrrpitoautnindg otroatsheanskiningroefdiaenstubofstraunbtbiaelrnsutomckbse.r of people, either doseD, oefnt1o0n0 amndg/kcogwfoorrkaer2s29mhoauvteh fpeedritohdi.s Dcoepmipgmouenndtattoionguoinf etahephigasiraotccaurdraeidly, gbuuitnethaerpeigws oirne anno aopthperroxsiimgnasteofamtooxuicnittyo.f P1e2ekg aonvderSoabo5tkmao30nthhavpeerfieodd.itNtoo dLeeprnigemr eanntdatFiointzpofattrhiecksk31infoournhdainrooctocuxricrecdh, aanngdesthienremwiceerewnhoicshignwseoref tionxjeiccitteyd. icnotwroarpkeerritso32nheaalvlye fwouitnhd 0t0h0atmcagn/kcegr ppeartiednatys tfoolreraate3d woereakl dpoesreisodo.f uKpeltloy 1a0ndg perCdaaryefwulithuoseutosfigthnsisocfotmoxpiocuitnyd. is necessary in order to avoid skin contact. Octa3m2.inMc)o.--noAocgteyrlitaendStadlioitcetyhUalsiphbcenenylafmedinteo (rAagtseraitte tShrtaeleitele, vAelgscrinitethSetiarlidteaiSly, dofiemt:o2r5t0a0li,ty50w00a,safnodun1d0,0a0t0apnpymofovthere afe0e4diwngeeklevpeelrsi.odS.omNoe imncilrdeaesfefdecitnscoidnenthcee liverHuwmeraenobpsaetrcvhedteasttsnpeecrrfooprsmye15d. with Agerite. Stalite using the repeat insult mtecehnntiinqgueagshenowt16.thTahteitsiinsgnleeitmheinrima aplrilmetahrayl iorrraitlandto,sae sfoenrsirtaizbebri,tsnoisr aapdperpoixgi- matTelhyes1e5 amnlt,i/okxgi1d5.ants have been used widely for a number of years in the rubb33er. iKnidcuks'dtrydiwhuitthyldniothrioepcaorrbteadmaotcecur(rNeBncCe)s.--ofTahdeveraspeperfofxeicmtsa. te lethal oral dsoolsuetiofonr irnatsanisa1c7etogn/ke-gd.ioWxahneen mapixptluierde, tonothsekinskiinrriotfatgiounineoaccpuirgrseda.s Aa 2100%% sooflsuetniosnit,ivsiitmy.ilarly applied, produced only mild erythema. There were no signs inasMmuodcheraasteelyxpcoasruerfeultohannicdklienlgcosmhopuoludndbes ceaxrerriceissesdomine pusoitnegnttiahlisricsokm. pound, been34c.oPndliuenctyeld-a-unsaipnhgth3yldaomgisn,ew(NitheozaondeaiAly)2.a--dmLionnigst-rteartmionfeoedf i2n9g0stmudgie5s dhaavyes apbersenwceeekoffobrla3d0detro t4u2mmorosn33t.hs. No signs of toxicity were found, including the teerAs pdpidlicnaotitocnauosfeasnkianquireroituastiopnasoter steontshiteizsaktiinono33f. each of 199 human volun the Rperceesenntcdeatoaf d/3e-vnealpohpte.dhyblaynhiiiigichluypsetnosi3t0iveppamnaliyntipcalilepnryol-cae-dnuarpehsthhayvlaemshinowe3n4. Tnahpishthisylbaemliienveedhatsopebrehatposxieaolwloagyiosuclloyntianinsiegdni/f3ic-nanutp,htihnyalsammuiciihe oafs apbloiuentytlh-aisswaimtheplehvcenljda-nad-nnaophatdhvyelrasme ienfcfeocvtserhamvaenybeyenearseseonf iunsee.ither animals or humans been35f.edPhdeiemtjal-r(y3-lneavpehlsthuyplamtoin1e%(oAfgtehreitier dPaoilwydderie, t Nfoeroz7o1neweIe)k)s2.--witRhatnso shiganves ohfavcearbceiennogfeednic5i1t0y;inhgo, wfievveerfl,ayssompeer kwiedenkeyforda5m0-a5g4e mwoansthfso,uanndd. oTnherefleogd1o0g0s wmegr,ekfgoupnedr33d.ay for 45 mouths. No signs of bladder tumors or other toxicity The similarity in name between phenvl-/3-nnphthylamine and the recog- HEALTH CONTROL (35 rwiiiztehd rheismpmecnt ctaorctinhoegecna,r/cSin-noagpehntihciythyunoifneplIime.nsyblie3e-nnnthpehtchayulsaenoiifnemuocvherconmcaenrny ytheearse.xpTehriisenicseonine othfisthuesoeldheasst abneetnioxeindtainretlsyufsaedvorinabtlhee. rMuobtbherWinildliuamstsr'y15, aanndd Sphcoentty36l-/h3a-nvaephcittheydlatmhienea.bsence of bladder tumors in producers and users of ceduRreecsehnatvdeasthaoawcnqutihreedprtehsreonucgehofth/Je-nuaspehtohfyhlaigmhilnye sienncsiotmivme earncaiallytgicraaldepsroof lpohgeicnaylI-s/i3g-nniafpichatnhcyel,aminiansemuupchtoas5t0heppcmom34m. Terhciisalisgrbaedleievoefdphtoenhyal-v/3e-nnaophtothxyiclao- iitnsinuesehahsapsronboatbblyeeanlwaasysosccioantetdaininedalneyvelwsaoyf twhiitshmtuhcehp/9r-ondaupchtitohnylaomf ibnlea,dbdeurt tum3o6r.s.Phenyl-0-naphthylamine-acetone resin (Betanox Special)2.--There is no feaxvpoerraimbleen. tal toxicology reported. Its use in the rubber industry lias been very been37c.oPndoluycatlekdylpwoiltyhphreantsolov(eArgaeri6t2e wSueepkerplietrei)o.--d Ousrianlg fteherdeiengdisettuardyiesle16vehlsavoef 2ta5l0it0y,. 5T00h0e, parnidnc7ip5a0l0 spitpems .ofThtoexihcigehfefescttslevweelreprtohdeuckeiddnseoymeanidnclrievaesre.dTmheosre tfheeoduignhg elefvfeeclsts, owferceouorbses,eravreed,retlhaetivceolmy phoiughndfoirs pnrootlorneggeadrdfeededainsg,vearnyd toexviecn. Its 3u8s.e Sinlyrtehnearteudbbpehreninodlsus(tWryi,nogvsteary mSa, nAygyeeraitres,Shpaasr)b2.e--enTehnetiGreolyodfyaevaorraTbilree. aFnivde Rgruabdbeedr dCoosemsphaanvye hbaesenpeferdfortmo erdatschartolneivcelfseerdainngginsgtufdrioems o5ntoW5i0n0gsmtagy/kSg. fleovrelas,31658weaenkd p5e0r0iomd.g/Rkegt.arAdtatthioenenodf gorfow12thweweakss,fnouonodthaetr tshigenstwoof thoixgihceitsyt wer3e9s.eeBnu13t.ylated-styrenated phenol ( Wingstay F).--Two-year feeding studies nwoithevWidienngcsetaoyf Vtooxnicritayt,s aenxcdedpot gms,oadtelreavteelsduepprteoss1io5n8 mofg/fkoogdpeinrtdaakye, apnrdodbuocdedy awlel irgehstpoinnstehsewcearseenoofrmraatlsinatbtohteh hspigehceiesst13d. osage level. At 50 mg/kg per day, men4t0a.l Nto-xSitceoalroogyyl-pin-admiciantoesphaennoolral(SLuDco6noofxor 1r8a)t.s--ofTh<e11ongl/ykgr3e7.ported experi rubbTehrerinedhuastvrey.been no reported ill effects from use of this compound in the mal41le.th4a,4l'-dTohsieo-fboirs{rdai-tss,eca-dammyinlpishteenreodl) in(Saunntdoiwluhtieted Lfo).r--m,Tihse >a2cu0teg/okrga,l wmhinilie itshteeraecduitne umnidniilmutaeldleftohraml ,diosse>1b0y gp/ekrgcu. tTanheeoucosmapbosuornpdtioisnnofonr-irrarbitbaittisn,gatdomtihne sthkeineoyfesraobfbriatsb.bIitts6p.roduces slight irritation when administered undiluted into antiTohxiedraenta.re no reported ill effects associated with industrial use of this sant4o2.C4o>m4'p-Tanhyio-rbeipso(6r-ttseral-nbtailcyul-tme-correaslolL) D6(0Safonrtorwahtsit,ewCherynstfaelds)2a.s--aTh.5e0%Msouns pReantssiohnavine oblieveen ofiel,dodf i2e3ta4r5ymlegv/kelgs, oafnd0.0fo0r5raabnbdit0s.0a5p%profxoirm3atmelyon3t2h0s0wmitgh/kngo. signs of toxicity except a retardation of growth at the 0.05% level5. The 030 RUBBER CHEMISTRY AND TECHNOLOGY vMoolunnstaenetros aCnodmpruabnbyerliapsatccohnesduccotnedtainhiunmganSanptaotwchhitteesCtsryusstainlsg a2s00thehuamnatni iorxriidtaanntt.nTohresernessiutilztserh5a.ve been favorable, indicating that it is neither a primary c a l l4y3.hi4n,d4e'r-Tedh io-bis(6-tert-butyl-o-cresol) phenolic antioxidant ha s (E a t hyl Antio Reported xidan acute t 736 oral ) .L--DT50h ios f s6te3r4i0- rmagts/)k.gThwihseins aadrmeliantiisvteelryedlowas laev2el0%of tsooxluictiitoyn. iNnopsepaencuiatl ohial5n8d(lpinrgespurmocaebdlyuretos are 4r4e.coNm-mPhenendeydl-Nb'y-(pth-teolmueanneusfualcjtounryelr).-p-phenylenediamine (Aranox)2.--There yiseanros' ruespeorintedtheexrpuebrbiemreinntdaul sttoryxicwoiltohgynoforreptohritsedaneatisoexsidoaf natn.yIpt rhobaslemovse. r 30 oral45t.oxTicriit(ymifxocrdramtsonsohoawnsd adninoLnDy5lp0hoefny1l0)p.5hogs/pkhgi.teT(wPoo-lyyegaarrdf)'e1e.--diTnghestaucduietes swliegrhetpteorxfoicrmefefdecwtsitwherr.evtsseaenndadtotghseaht idgiheetsatrylelveevle. lsRueppetaote1d watp%pliocfattihoen foofodth10e; suknidniliurtreidtatcioomn pbouutn1d10teovtidheensckeinofosfyrsatebmbiitcs thoaxsicpirtoyd10u. ced definite but transient skinBiarsreidtatuiopnoninaninimduasltreixalpeursiemoefnttahtiisonc,omthpeoruenadp. pHeaorwsevtoer,bethseomhiestorirsyk offroimts use4o6v.ert,3a,5n-uTmribneirctloiyfly-2ea,4r,s6-htraisfi(b3e,e5n-dif-atverotr-ahbnltey.l-4-hydroxybenzyl) benzene (Anti aoxcuidtaenLt D336o0)v.a--luTehoisf 1c5omgp/kogun(dprheasusmaabvelyrytolorwatso)r.aNl itnoexticyi-tdya, ywfietehdiangresptuordtieeds tmoitrtaetds uapt atod0i.e5tawrty %levinelpoofly3m.1e6r%s bpyrtohdeuc1eJ.dS.noFosoigdnaifnicdanDtruefgfeActdsm39.inIitstirsatpieorn for food contact applications40. 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DPeecnktoann,dAH. .BS. oLbeorntkear,, aJn. dInTve.sBt..DFeirtmzpaatotrli.c4k,, 3J2.5In(1ve9s4t1.)D. ermatol. 18. 110 (10521. 8818 AK.. BH.. LKeerlnlyer, Han. dRT. B. Bie.rmFaitnz,paantrdicMk,.JB..ASmhiemr.kMine, dP.roAcs.sS. a1cS.2E, x5p77. I(li1a0!5. 3M).ed. 79, 580 (1052). 88 HaskteollcLusatboomraetros,ryA, uEg.. 1I.8,du19P7o1n. t do Nemours and Go., Wilmington, Del., Memorandum 88 ElastaonmdeurmCthoemcuicsatolsmDeresp, tA.,uEg.. I1.8D, 1u9P7o1n. t de Nemours and Go., Wilmington, Del., Memor 88161TM..8C. .SHco. tWt, iCllaiarmcins,ogCeanniccear,ndVoCl.h3ro, nBicutTteorxwicorHthazaanrddsCoof., ALrtodm., aLtiocndAomn,in1e0s,58E, lpse. v3iGer3.Pub 88 MileslisLhainbgorCatoo.r,ieNse, wElYkhoarkrt,, 1I9n0d2.., communication. 8*8* EEtthhyyll,CCoorrpp..,, PPrroodd.. BBuullll.. 733300,, BBaattoonn Rltoouuggee,, LLaa.. 48 U. 8. Food and Drug Admin., CFR 121.2500, Fed. Regist.