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REARC226 - 1123
september 17,2002
VIA FEDE] bi
Document Control Office (DCO)
Officeof Pollution Prevention and Toxics (OPPT)
Wasp 18 faye 02
EPA East, Room 6428
`1W2a0s1hiCnogntsotni,tuDt.iCo.n
Avenue,
20460
NW
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iFYI-00-801i378
Attention: Docket No. AR-226 and the FY1 Docket
Re: Information on Perfluorooctane Sulfonates and Related Compounds
Dear Sir or Madam:
"rTehliastecdonctoimnpuoeusn3dMs',savsoplaurnttoafryousrubomnigsosiinognsdioafldoagtuaeownitpherEfPluAorroeogcatradniengsufllfuoonraotcehsemaincdals.
On August 30, 2002, a meeting was held between USEPA personnel and the
representatives from the Fluoropolymer Manufacturer's Groupofthe Societyofthe
PplearsttaiicnsinIgndtuosatrmymtoondiiuscmuspsersfcileunotriofoicctaasnpoeacttes tohftathweerreesuplrtesvoifotuwsloy tsouxbimciotltoegdytsotAudRi-e2s26.
The studies discussed were the six-month oral toxicity study in male cynomolgus
`monkeys
`meeting,
aandedttahielemdualntail-ygseinseroaftiroanw
reesptrrooduuscctyicolni/ndgevdaetlaopfmreonmtatlhestlautdtyerinstrautds.y
At
was
the
presented by Dr. John L. Butenhoff, 3M. As an action item from the meeting, it was
agreed that the raw data and its analysis would be submitted formally to AR-226 with
additional analyses that may be helpful in
intentofthis submission is to provide the
understanding the results
raw data and analyses, as
ofthe study. The
agreed on August
30,
2002.
Included in this submission are the following:
An exact copy of raw estrous cycling data for P and F1 females from Argus Research
Protocol 418-020, "Oral (Gavage) Two-Generation (One Litter per Generation) Reproduction Study of Ammonium Perfluorooctanoate (APFO) in Rats".
AObsteabrlveat(itowno Dpaatgae"s)wehnitcihtl,edi,n "aEdsdtirtoiuosn CtoycdlaitangonanedstNraotuusraclycDleilnigv,ecroyn/tLaiittnesrinformation
on mean litter numbers of implantation, liveborn, and stillborn by dose group.
An analysis ofP and F1 generation estrous cycling data made subsequent to the August 30, 2002 meeting and including colored charts which graphically represent the raw estrous cycling data.
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Document Control Office: September 17, 2002 Page2 We will continue to provide information as it becomes available. Please feel fice to contact me with any questions. Very truly yours, Michael A. Santoro DirectorofEnvironmental, Health Safety and Regulatory Affairs Specialty Materials Markets 3M Building 236-1B-10 St. Paul, Minnesota 55144 651-733-6374 (phone) 651-733-1958 (fax) E-mail: masantoro@mmm.com ce: Dr. Charles Auer
Dr. Oscar Hemandez.
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