Document jB30K1ER7rnKz7J0Bm9Ve9N3Z
ELLEN KOVNER SILBERGELD, Ph.D.
I. Qualifications
Dr. Silbergeld is an environmental scientist and toxicologist who
is the Chief Toxicologist for the Environmental Defense Fund and a Research
Scientist in the Reproductive Toxicology Laboratory of the National Institutes
of Health in Bethesda, Maryland. Her curriculum vitae is attached.
II. Subject Matter
Dr. Silbergeld will testify in the following areas:
A. Receptors/TCDD, including:
1. the receptor model and its role in physiology; 2. the detection of receptors and the mode of how
receptors are linked to function; 3. the mode by which receptors recognize TCDD, that
is, e.g. structural "fine-tuning"; 4. the existence of receptors in humans, and in their
various organs, with the implications of their presence for TCDD potency; 5. its occupancy by the TCDD ligand and its relation ship to the biological effects of TCDD at the subcellular level, specifically;
a. DNA-RNA directed proteinsynthesis; b. enzyme induction; c. pleiotrophic changes in the cell.
B. Animal toxicology, and more specifically the extrapolations between animal data, and its predictive qualities in humans, including:
1. biological bases for interspecies comparision; 2. mathematical models for such extrapolation; 3. physiological chemistry among mammalian systems
(including humans); 4. relevant studies on derived cell lines from humans.
C. Reproductive toxicology, and more specifically the effects of TCDD and 2,4,5-T on reproductive physiology in the male and female, including:
1. Gonadotoxicity; 2. Endocrine toxicity; 3. Alteration in hormonal metabolism;
4. Teratology; 5. Feto-toxicity; 6. Significance and persistence of such effects
in animals and humans; 7. Sensitivity of the reproductive system, both
endocrine and gonadal, to the receptor-mediated effects of TCDD.
D. Neurotoxicology, and more specifically the various effects of 2,4-D, TCDD and 2,4,5-T on peripheral and central nerous system functions, including:
1. Neuromuscular control; 2. Nerve conductive dynamics; 3. CNS function (including cognitive, motor, and
affective aspects); 4. Experimental and clinical studies with particular
emphasis on:
a. dose-response mechanisms; b. acute versus chronic exposure; c. early versus long latency effects.
5. Methods for assessing nervous system functions in animal and humans, including:
a. neurochemistry; b. electrophysiology; c. neurobehavioral techniques.
6. Interrelationships between effects on other organ systems and the nervous system, particularly with respect to altered porphyrin metabolism, including:
a. the effects of decreased cellular energy b. the effects of decreased heine-synthesis on
the integrity of myelin; c. the neuroactive properties of certain
porphyrin precursors.
III.
Scientific Principles
See General Statement of Scientific Principles and Assumed Facts
attached.
IV. Substance of Opinions
A. That animal data has and can be used, particularly with respect to 2,4-D, 2,4,5-T, and TCDD to demonstrate their potential and real toxicity, neuro-toxicity, reproductive toxicity, and carcinogenicity in humans.
B. That TCDD receptors exist in human cells, and in their various organs, which are similar, if not identical, to the TCDD receptor described in rodents; that this fundamental cellular mechanism explains scientifically many of the toxic (including carcinogenic) effects of TCDD, and moreover provides a scientific basis for predicting similar toxic effects in humans as in experimental animals; that this receptor explains the very great, indeed exceptionalpotency of TCDD as an acute and chronic toxin (including carcinogen).
C. That TCDD and 2,4,5-T can and, under certain circumstances, will cause male-mediated transmittable damage manifesting in birth defects, miscarriages, and other untoward pregnancy outcomes.
D. That 2,4-D, TCDD, and 2,4,5,-Td are neuro-toxic.
V. Grounds for each Opinion
A. General
The bases for Dr. Silbergeld's testimony as to various facts and opinions include: educational background; professional training and experience; personal research; review of clinical data as set forth in attachments; review of the medical and scientific literature.
B. Specific
1. As to opinion IV A, i.e. animal toxicology, see list of references and other grounds under "Animal Toxicology" attached.
2. As to opinion IV B,i.e. role of receptors in the presence of TCDD, see list of references and other grounds under "Receptors/TCDD" attached.
3. As to opinion IV C, i.d. as to male-mediative genetic damage, see list of references and other grounds under "Reproductive Toxicology" attached.
4. As to opinion IV D, i.e. as to neuro-toxicity of Agent Orange, see list of references and other grounds under "Neurotoxicology" attached.
SILBERCLED - NEUROTOXICOLOGY
Bleiberg, Walon, Brodken and Applebaum, 1964; Archives of Dermatology, Volume 89, p. 793.
Poland and Smith, 1971, Archives of Environmental Health; Volume 22, p. 316.
Kimbrough, 1974, CRC Critical Reviews in Toxicology, p. 445.
Lucier, Sonawane, McDaniel and Hook, 1975, Chemical Biological Interaction, Volume 11, p. 15.
Oliver, 1975, British Journal of Industrial Medicine, Volume 32, p. 49.
Sjoden and Soderberg, 1975, Physiological Psychology, Volume 3, p. 175.
Jerosek, Kolenski, Kubek, Pasturova and Lucash, 1976, Ha,,far7l.________________ Volume 27, p. 328.
Kociba, Keeler, Park and Gehring, 1976, Toxicology and Applied Pharmacology, Volume 35, p. 553.
Allan, Barsotti, Van Miller, Abrahamson and Lalich, 1977, Food, Cosmetics and Toxicology, Volume 15, p. 401.
Elovaara, Savolainen, Parkki, Aitio and Vanio, 1977, Research Communications, Chemical Pathology and Pharmacology, Volume 18, p. 487.
Farrah, 1977, Teratology, Volume 16, p. 365.
McConnel, Moore, Harris and Haseman, 1977 , Environmental Health Perspectives, Volume 20, p. 245.
Kociba, Keys, Beyer, Carreon, Wade, et al., 1978, Toxicology and Applied Pharmacology, Volume 46, p. 297.
Marcilos, Terronon and Aitio, 1978, Zenobiotica, Volume 8, p. 397.
Bogen, 1979, Journal of the American Medical Association, Volume 242, p. 2391.
Field, 1979, Lancet, Volume 1, p. 1342.
Nienstedt, et al., 1979, Toxicology, Volume 13, p. 233.
Strik, 1979, Annals, New York Academy of Sciences, Volume 320, p. 308.
Strik and Koeman, 1979, "Chemical Porphyria in Man."
Zach and Suskind, 1980, Journal of Occupational Medicine, Volume 22, p. 11.
Cantoni, Salmona and Rizzardini, 1981, Toxicology and Applied Pharmacology, Volume 67, p. 156.
Pazderova, Lucas, Pickova and Jirasek, 1981, Archives of Environmental Health,
Volume 36, p. 5.
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International Society for Neurochemistry and International Brain Research Organization Meetings on Neurotoxicology
Editor, Journals on Neurotoxicology and Neurobehavioura1 Toxicology and Teratology
Res ear ch at NIH and Natio nal Center for T ox ico lo gy Research
SILBERGELD - RECEPTORS/TCDD
Vos, Moore and Zinkl, 1973, Environmental Health Perspectives, Volune 5, p. 149.
Kouri, Ratrie, Atlas, Niwa and Nebert, Life Sciences, Volume 15, p. 1585.
Vos, Moore and Zinkl, 1974, Toxicology and Applied Pharmacology, Volume 29, p. 229.
Beatty and Neal, 1975, Toxicology and Applied Pharmacology, Volume 33, p. 151.
Kimbrough, 1974, CRC Critical Reviews in Toxicology, p. 445.
Kupfer, 1975, CRC Critical Reviews in Toxicology, Volume 4, p. 83.
Oliver, 1975, British Journal of Industrial Medicine, Volume 32, p. 49.
Poland and Glover, 1975, Molecular Pharmacology, Volume 11, p. 389-398.
Barry, Zacharia, Namkung and Juchau, 1975, Toxicology and Applied Pharmacology, Volume 36, p. 569.
Goldstein, McKinney, Lucier, Hickman, Burgman and Moore, 1976, Toxicology and applied Pharmacology, Volume 36, p. 81.
Alastair Hay, 1981, "The Chmeical Scythe."
Kimbrough, Editor, 1980, Halogenetic Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products.
Poland and Kende, 1976, Federation Proceedings, Volume 35.
McConnel, Moore, Haseman and Harris, 1978, Toxicology and Applied Pharmacology, Volume 44, p. 335.
McConnel, Moore, Harris and Haseman, 1977, Environmental Health Perspectives, Volume 20, p. 245.
Kociba, Keys, Beyer, Carreon, Wade, et al, 1978, Toxicology and Applied Pharmacology, Volume 46, p. 297.
Boobis, Nebert and Paelkonen, 1979, Biochemical Pharmacology, Vo Ikbb 28, p. 11.
Carlstedt-Duke, Elstrom, Hogburg and Gustofsun, 1979, Journal of Biochemistry,
Carlstedt-Duke, 1979, Cancer Research, Volume 39, p. 3172.
Gasiewicz and Neal, 1979, Toxicology and Applied Pharmacology, Volune 51, p. 329.
Greenly and Poland, 1979, Journal of Biological Chemistry, Volume 254, p. 9814.
13608Gunther, Fysh and Nebert, 1979, Pharmacology, Volume 19, p. 12.
Kociba, Keys, Beyers, Carreon and Gehring, 1979, New York Academy at Sciences, Volume 320, p. 204.
. J i_ _ j .. _ i
P o l a n d & Smith, 1971, A r c h i v e s of E n v i r o n m e n t a l H e a l t h , Vol. 22, p. 316 Huff, Moore, Saracci and Tomatis, 1980, Environmental Health Perspectives, Volume 36, p. 221. Strik, 1979, Annals, New York Academy of Sciences, Volume 320, p. 308. Strik and Koeman, 1979, "Chemical Porphyria in Man." Olson, Gasiewicz and Neal, 1980, Toxicology and Applied Pharmacology, Volume 56, p. 78. Olson, Hoscher and Neal, 1980, Toxicology and Applied Pharmacology, Volume 65, p. 67. Poland and Glover, 1980, Molecular Pharmacology, Volume 17, p. 86. Eisen, Hanna, Legraverend, Okey and Nebert, 1983, Journal of Biological Chemistry, Legraverend, Hanna, Eisen, Owens, Nebert and Henkens, 1982, Journal of Biological Chemistry, Volume 257, p. 6402. Tukey, Hanna, Negishi, Nebert and Eisen, 1982, Cell, Volume 31, p. 275. Okey, Bonde, Mason and Nebert, 1980, Journal of Biological Chemistry.
Participation as invited Speaker and participant in International Symposia on TCDD conducted by Rockefeller University (October, 1983). Current Research in the Reproductive Toxicology Section NICHD NIH Papers in Preparation describing'this research. Training and Research experience at Johns-Hopkins and the NIH in receptor and cellular biochemistry and toxicology. Society for Occupational and Environmental Health (December, 1983)
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SILBERGELD - REPRODUCTIVE TOXICOLOCY
Courtney, Daler, Hogan, ec al., 1970, Teratogenic Evalation of 2,4,5-T; Science Volume 168, p. 864.
Sparschu, Dunn and Rowe, 1970, Toxicology and Applied Pharmacology; Volume 17, p. 317.
Courtney and Moore, 1971, Toxicology and Applied Pharmacology; Volume 20, p. 369.
Khera and McKinley, 1972, Toxicology and Applied Pharmacology; Volume 22, p. 14.
Moore, Glupta, Zinkl and Vos, 1973, Environmental Health Perspectives, Volume 5, p . 81.
Neubert, Zens, Rothenwallner and Merker, 1973, Environmental Health Perspectives, Volume 5, p. 67.
Kimbrough, 1974, CRC Critical Reviews in Toxicology, p. 445.
Kupfer, 1975, CRC Critical Reviews in Toxicology, Volume 4, p. 83.'
Lucier, Sonawane, McDaniel and Hook, 1975, Chemical Biological Interaction, Volume 11, p. 15.
Oliver, 1975, British Journal of Industrial Medicine, Volume 32, p. 49.
Gjoden and Soderberg, 1975, Physiological Psychology, Volume 3, p. 175.
Barry, Zacharia, Namkung and Juchau, 1976, Toxicology and Applied Pharmacology, Volume 36, p. 569.
Courtney, 1976, Bulletin of Environmental Contamination and Toxicology, Volume 16, p. 674.
Alastair Hay, 1981, "The Chemical Scythe"
Kimbrough, Editor, 1980, Halogenetic Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products.
Kociba, Keeler, Park and Gehring, 1976, Toxicology and Applied Pharmacology, Volume 35, p. 553.
Smith, Schwetz, and Nitschke, 1976, Toxicology and Applied Pharmacology, Volume 38, p. 518.
Allan, Barsotti, Van Miller, Abrahamson and Lalich, 1977, Food, Cosmetics and Toxicology, Volume 15, p. 401.
Earry, Slaga, Wilson, Zacharia, Namkung, et al. , 1977 , Biochemical Pharmacology, Volume 26, p. 1383.
13610
F a r r a h , 1977, T e r a t o l o g y , V o l u m e 16, p. 365.
McConnel, Moore, Harris and Haseman, 1977, Environmental Health Perspectives, Volume 20, p. 245.
Kociba, Keys, Beyer, Carreon, Wade, et al., 1978, Toxicology and Applied Pharmacology, Volume 46, p. 297.
Barsotti, Abrahamson and Allan, 1979, Bulletin, Enviroanental Co nt ami na tio n and Toxicology, Volume 21, p. 463.
Bogen, 1979 , Journal of the American Medical Associaffi., Volume 242, p. 2391.
Field, 1979, Lancet , Volume 1, p. 1342.
Kociba, Keys, Beyers, Carreon and Gehring, 1979, New Tork Academy of Sciences, Volume 320, p. 397.
Murray, Smith, Nitscheke, Humaston, Kociba and Schwetcz, 1979 , To xi co lo gy and Applied Pharmacology, Volume 50, p. 2 741.
Schantz, Barsotti, and Allan, 1979, T o x i c o l o g y and A [P plied Pharmacology, Volume 48, p. 360.
Cook, TowHsend , Opst, and Silverstein, 1980, Journ al or' Occupational Medicine, Volume 22, p. 530.
Lee and Suzuki, 1980, Journal of P h a r m a c ol o g y and Experiment a 1 Therapeutics, Volume 215, p. 501.
Cantoni, Salmona, and Rizzardini, 1981, T o x i co l o g y arnd Applied Pharmacology, Volume 67, p. 156.
McNolte, Pomerantz, and Farrell, 1981, Food, Cosmetic cs, Toxicology Volume 19, 0. 57.
Remotti, Virgilis, Bionco, and Candiani, 1981, Placerntz, Volume 2, p.
Townsend, Bodner, Van Peenen, Olsen and Cook, 1982, ^American Journal Epidemiology, Volume 115, p. 695.
Lamb, Marx, Gladen, Allen and Moore, 1981, Journal o:'f Toxicology and Enviorn me nta l Health, Volume 8, p. 825.
Research at Na tional Institute of Health
Research Reproductive Toxicology Section NICHD
SILBERGELD - ANIMAL TOXICOLOGY
Bleiberg, Walon, Brodken and Applebaum, 1964; Archives of Dermatology, Volume 89, p. 793.
Poland and i>mith, 1971, Archives of Environmental Health; Volume 22, p. 14.
Moore, Glupta, Zinkl and Vos, 1973, Environmental Health Perspectives, Volume 5, p. 81.
Vos, Moore and Zinkl, 1973, Environmental Health Perspectives, Volume 5, p. 149.
Kouri, Ratrie, Atlas, Niwa and Nebert, Life Sciences, Volume 15, p. 1585.
Vos, Moore and Zinkl, 1974, Toxicology and Applied Pharmacology, Volume 29, p. 229.
Carter, Kimbrough, Liddel and Cline and Zach, 1975 , Science, Volume 188, p. 738.
Kimbrough, 1974, CRC Critical Reviews in Toxicology, p. 445.
Oliver, 1975, British Journal of Industrial Medicine, Volume 32, p. 49.
Poland and Glover, 1975, Molecular Pharmacology, Volume 11, p. 389-398.
Goldstein, McKinney, Lucier, Hickman, Burgman and Moore, 1975, Toxicology and Applied Pharmacology, Volume 36, p. 8L.
Alastair Hay, 1981, "The Chemical Scythe"
Kimbrough, Editor, 1980, Halogenetic Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products.
Jerosek, Kolenski, Kubek, Pasturova and Lucash, 1976, Hautarzt___________ , Volume 27, p. 328.
Farrah, 1977, Teratology, Volume 16, p. 365.
McConnel, Moore, Harris and Haseman, 1977, Environmental Health Perspectives, Volume 20, p. 245.
Crow, 1978, Annals, Occupational Hygiene, Volume 21, p. 297.
Kociba, Keys, Beyer, Carreon, Wade, et al., 1978, Toxicology and Applied Pharmacology, Volume 46, p. 297.
Marcilos, Terronon and Aitio, 1978, Zenobiotica, Volume 8, p. 397.
McConnel, Moore, Haseman and Harris, 1978, Toxicology and Applied Pharmacology, Volume 44, p. 335.
Bogen, 1979, Journal of the American Medical Association, Volume 242, p. 2391.
Gasiewicz and Neal, 1979, Toxicology and Applied Pharmacology, Volume 51, p. 329. Kociba, Keys, Beyers, Carreon and Gehring, 1979, New York Academy of Sciences, Volume 320, p. 397.
Luster, Face and Lawson, 1979, Drug and Chemcial Toxicologies, Volume 2, p. 49.
Neal, Beatty and Gasiewicz, 1979, Annals, New York Academy of Sciences, Volume 320, p. 204. Nolan, Smith and Hefner, 1979, Toxicology and Applied Pharmacology, Volume 48, p. 16
Strik, 1979, Annals, New York Academy of Sciences, Volume 320, p. 308.
Strik and Koeman, 1979, "Chemical Porphyria in Man."
Huff, Moore, Saracci and Tomatis, 1980, Environmental Healthi Perspectives, Volume 36, p. 221.
Okey, Bonde, Mason and Nebert, 1980, Journal of Biological Chemistry. Poland and Glover, 1980, Molecular Pharmacology, Volume 17, p. 86. Zach and Suskind, 1980, Journal of Occupational Medicine, Volume 22, p. 11. Pazderova, Lucas, Pickova and Jirasek, 1981, Archives of Environmental Health, Volume 36, p. 5. Lamb, Marx, Gladen, Allen and Moore, 1981, Journal of Toxicology and Environmental Health, Volume 8, p. 825. Tukey, Hanna, Negishi, Nebert and Eisen, 1982, Cell, Volume 31, p. 275.
Attendance International Symposium on TCDD, Rockefeller University (Oct., 1983) M ember EPA Expert Committee on Dioxin (July, 1983) Service EPA Expert Committees on Several Toxins Review Clinical Data, Nitro, W . V a . , Seveso, Italy, Times Beach, Mo . Exp er ienc e in Risk Assessment
Exp er ienc e in toxi colo gy & toxicology assessment
RAYMOND SINGER, Ph.D.
I. QUALIFICATIONS Dr. Raymond Singer, Ph.D., is a neurotoxicologist and neuropsycholo
gist practicing at Occupational Health Consulting, Inc., New York, New York. Dr. Singer's curriculum vitae is attached.
II. SUBJECT MATTER Dr. Singer will testify to the toxic effects of toxic chemicals,
Agent Orange, PCDD and TCDD on the human nervous system and the consequences thereof. Dr. Singer will testify to various studies, including a study conducted by Dr. Singer, which demonstrate the nervous disorders resulting from exposure to Agent Orange and TCDD. His testimony will also include an explanation of the method using nerve conduction velocity studies to show the resulting nervous disorders and the results of the examination of each representative plaintiff.
III.
GENERAL SCIENTIFIC PRINCIPLES
The effects of phenoxv herbicides and related contaminants have
been studied in a number of research efforts in both animals and humans. These
include case reports and epidemiological reports. Occupational health studies
are often helpful in determining the toxicity of chemicals.
13614
The doctor will testify to a review of the literature concerning the evidence of toxicity in humans to the central nervous system and the peri pheral nervous system.
Dr. Singer will not testify on the biochemical process within the body by which the nervous system results are produced, but merely on the pre sence of those results in the literature and the fact that there are deficits in mental and nervous function that can be related to herbicide toxicity. Some of the specific areas are set out below in relation to his opinions.
IV. SUBSTANCE OF OPINIONS
Dr. Singer's opinions are as follows:
1. Agent Orange and its contaminant TCDD can cause nervous system
damage in humans, which will vary from individual to individual.
2. Agent Orange and its contaminant TCDD produce central nervous
system effects which include:
a. Irritability.
b. Nervousness.
c. Sleep Disorders.
d. Memory Problems.
e. Other Mental Dysfunctions.
They also produce neuropsychological results which include distortions of per
ceptual function and cognitive reaction time.
3. Agent Orange and its contaminant TCDD produce peripheral ner
vous system effect, which include:
13615
a. Numbness. b. Loss of Feeling. c. Weakness. d. Pain. 4. The neurophysiological results include a slowing in nerve conduction velocity and a probable reduction in amplitude. 5. The nerve conduction velocity tests are the most reliable method of determining the presence of peripheral nervous system effects. 6. The opinion testimony to be offered in relation to each of the representative plaintiffs is set forth in the individual reports Dr. Singer has prepared for each.
V. GROUNDS FOR EACH OPINION
Attached is a copy of Dr. Singer's article entitled Nerve Conduction
Velocity Studies Of Workers Employed In The Manufacture Of Phenoxv Herbicides.
The article reports the test results which the doctor obtained from review of
plant workers in Jacksonville, Arkansas. Either at the time of the study or
previously thereto, the plant was owned by defendant Hercules.
In addition, he has and will rely upon certain unpublished data
from tests he conducted of another group of workers at the Nitro, West Virginia
plant of defendant Monsanto Chemical Company in 1981.
Also , below is a list of references which Dr. Singer will rely upon.
A. Opinion IV(1) (Ref. Nos. 8, 26, 29, 35)
B. Opinion IV(2) (Ref. Nos. 2, 15, 19, 31, 37, 44)
1361^
c. Opinion IV (3) (Reference Nos 3, 31, 35, 3-7) D. Opinion IV(4) (Reference Nos 9, 10, 35) E. Opinion IV (5) (Reference Nos . 5, 12, 13, 41-4 3, 45, 46) In addition, Dr. Singer may rely upon some: or all of the following as the basis or his opinions: (Reference Nos. 1, 4, 6-7, 11-12, 14, 16-18, 20-25, 27-28, 30, 32-34, 36, 38-40, 47-52.)
21..
Anastasi, A. (1976). "Psychological Testing," 4th cd. Macmillan Co., New York. Ashe. W., and Suskind, R. R. (1950). "R epons on Chioracne C ases." Monsanto Chemical Co., Nitro,
West Virginia. Department of Environmental Health, University of Cincinnati College of
Medicine.
3. Bauer, H., Schulz, K. H., and Spiegelberg, U. (1961). Berufliche Vergif tungen bei der Herstellung
von Chlorphenol-Verbindungen. Arch. Gewerbephathol. Gewerbehyg. 18, 538--555. Reported in
IARC (1978). Long-term hazards of polychlorinated dibenzodioxins and polychlorinated diben-
zofurans.
3 . Behse, F ., and Buchthal. F. (1971). Normal sensory conduction in the nerves of the leg in man. J.
Neurol. Neurosurg. Psychiatry 34, 404--414.
4 . Behse, F., and Buchthal, F. (1978). Sensory action potentials and biopsy o f the sural nerve in
neuropathy. Brain 101, 473 --493.
5 . Berkeley, M., and Magee, K. (1963). Neuropathy following exposure to a dimethyiine salt of 2.4-D.
Arch. lnt. Med. I ll, 351-353.
6 . Berwick, P. (1970). 2,4-Dichlorophenoxyacetic acid poisoning in man. J. Am er. M ed. Assoc. 214(6),
1114-1117.
7 . Blei'oerg, J., Wallen, M., Brodkin, R., et al. (1964). Industrially acquired porphyria. Arch. Dermatol.
89, 793 -797.
8 . Boeri. E. (1980). "Cross-Sectional Neurological Study of a TCDD-Exposed Population in the Seveso
Area Compared with an Unexposed Population." Unpublished report, Instituto Neurologico,
Milano, Italy.
9 . Boeri. E., Bordo, B., Crenna, P., et al. (1978). Preliminary results of a neurological investigation of the
population exposed to TCDD in the Seveso region. Riv. Pat. N erv. M eat. 99, III --128.
10.
Bucher, N. L. R. (1946). Effects of 2,4-dichlorophenoxyacetic acid on experimental animals. Proc. Soc. Exp. Biol. Med. 63, 204-205.
11.
Buchthal, F., and Behse. F. (1979). Electrophysiology and nerve biopsy in men exposed to lead. Brit. J. Ind. Med. 36, 135-147.
12. Buchthal, F., Rosenfalck. A ., and Behse, F. (1975). Sensory potentials of normal and diseases nerves.
In "Peripheral Neuropathy" (P. J. Dyck, P. K. Thomas, and E. H. Lambert, Eds.), Vol. I, pp.
442 --464. Saunders. Philadelphia.
f
13.
Buiatti. E.. Cecchini, S., Ronchi, O., Dolara, P., and Bulgareili, G. (1978). Relauonship between clinical and electromyographic findings and exposure to solvents, in shoe and leather workers.
Brit. J. Ind. Med. 35, 168-173.
14. Cochrane, W ., Singh. J., Miles. W ., Wakeford. B.. and Scott, T. (1980). Analysis of technical and
formulated products of 2,4-dichlorophenoxy acetic acid for the presence of chlorinated dibenzo-
p-dioxins. Presented at the workshop Impact of Chlorinated Dioxins and Related Compounds on
the Environment, Rome, October 22-24, 1980.
15. Creso, E., De Marino, V., Donatelli. L.. and Pagini. G. (1978). Effette neuropsicofarmacologici della
TCDD. Boll. Soc. It. Sper. 54, 1592-1596.
16. Crow, K. D. (1970). Chioracne. A critical review including a comparison of two series o f cases of acne
from chlomaphthalene and pitch fumes. Trans. St. Johns H osp. Derm atol. Soc. 56, 79--99.
17.
D'Amour, M. L-, Shahani, R. R. Y ., and. Bird. K. T. (1979). The importance of studying sural nerve conduction and late responses in the evaluation of alcoholic subjects. N eurology 29, 1600--1604.
18. de Jesus, P. V ., Jr., Hausmanowa-Petrusewicz. I., and Barchi, R. L. (1973). The effect of cold on
nerve conduction of human slow and fast nerve fibers. N eurology 23, 1182--1189.
19. Desi, I.. Sos, J., Suie, F., and Markus. V. (1962). Nervous system effects of a chemical herbicide.
Arch. Environ. Health 4, 101 --108.
20. EIo, H. A ., and Ylitaio, P. (1979). Distribution of 2-methyl-4-chiorophenoxyacetic acid and 2.4-
dichlorophenoxyacedc acid in male rats: Evidence for the involvement of the central nervous
system in their toxicity. Toxicol. Appl. Pharmacol. 51, 439--446.
2 1 . Elovaara. E., Savolainen, F ,arkki. M. G., Aitio. A., and Vainio, ' 1977). Neunahemicai effects Pohf a2r.3m,7a.cSo-tl.etr1a8c, h3l.orodibenzo-'7-dioxin in Wistar and Gann rats. Res. Com m wuChem . Pathol.
22. Goldmann, P. J. (1972). Schwerste akute Chloracne durch Trichiorphenol-zerseczur$sprodukte. Arbeitsmed. Sozialmed. Arbeitshyg. 7, 12-18.
23.. Goldstein, N ., Jones, P., and Brown, J. (1959). Peripheral neuropathy after exposoe to an ester of dichloro-phenoxy acetic acid. JAMA 171(10). 1306-1309.
24. Goodgoid, J. and Eberstein, A. (1978). " Electrodiagnosis of D isease," 2nd ed. W3&ms & Wilkins, Baltimore.
25. Haiar, E. M., D eU sa, J. A ., and Bronzovich, F. V. (1980). Nerve conduction veloicitjrtReiationship of skin, subcutaneous and intramuscular temperatures. Arch. Phys. M ed. Rehab.61, 199--203.
26. Hay, A. W. M. (1977). Tetrachlorodibenzo-p-dioxin release at Seveso disasters. Disasers 1,289--308.
"Herbicide Handbook" (1979). Weed Science Society of America, 4th ed. Champaos, OI.
27. V ., and Carlisle, H. (1947). Toxicity of 2,4-dichlorophenoxyacetic acid fer experimental animals. J. Ind. Hyg. Toxicol. 29(2), 8 5 - 95.
28. Homberger, E ., Reggiam, G., Sambeth, J., et al. (1979). The Seveso accident: Its insure, extent and consequences. Ann. Occup. Hyg. 22, 327-370.
29. Huff. J. E., Moore, J. A ., Saracci, R., and Thomatis, L. (1980). Long-term hazards polychlorinated dibenzodioxins and polychlorinated dibenzoftirans. Environ. Health Persp e d . 3k 221-240.
30. Kimbrough, R. D. (1974). The toxicity o f polychlorinated polycyclic compounds aa related chemi cals. CRC Crit. Rev. Toxicol. 2,445 - 498.
31. Kleu, G., and Goitz, R. (1971). Spat-und Dauerschaden nach chronishgewerblicherEinwirkung von Chlorphenol Verbindungen. Med. Klin. 66, 5 3 - 58.
32. Kohli, J., Khanna, R., and Gupta. B. (1974). Absorption and excretion of 2,4.5-Eichlorophenoxy acede arid in man. Arch. Int. Pharmacodyn. 210, 250- 255.
33.
NielsMoned, .VS.cKan. d(.1917934),.
Sensory and 435-443.
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subjects.
Acta
34. Norstrom. A .. Rappe. C., Lindhal. R., and Buser. H-R. (1979). Analysis of some .older Scandinavian formulations of 2,4-dichlorophenoxy acetic acid and 2.4.5-trichiorophenoxy acek acid for con
tents of chlorinated dibenzo-p-dioxins and dibenzofurans. Scand. J. Work Emtton. Health 5,
35.
Pazd3e7r5ov-3a7-V8.ijlupkova. J., Nem cova, M., Pickova, J., Jiresek, L., and Lukas, E.. (US1). The devel opment and prognosis of chronic intoxication by tetrachlorodibenzo-p-dioxin in sen. Arch. Envi
36. Polarnodn.. AH.,eaalnthd K36e,n5d--e.1A1.. (1976). 2.3.7,8-TetrachIorodibenzo-p-dioxin: Environnneenl contaminant and the molecular probe. Fed. Proc. 35, 2404--2411.
37. Poland. A. P., Smith, D ., Metier, G., and Possick. P. (1971). A health survey of w ork oin a 2.4-D and
2.4,5-T plant. Arch. Environ. Health 22, 316--327. 38. Prescott, L. F,, Park, J., and Darrien, I. (1979). Treatment of severe 2,4-D and meccsrop intoxication
with alkaline diuresis. Brit. J. Clin. Pharmacol. 7, 111 --116. 39. Rosenfalk. P. (1975). " Electromyography-- Sensory and Motor Conduction Findings Normal Sub
jects." Technical report. Laboratory of Clinical Neurophysiology, Rigshospitati. Copenhagen.
40. SaueDrhenofmf,aMrk.., Braun, W,, Blau. W.. and Gehring, P. (1977). The fate of 2.4-dichloroB:noxyactic acid
(2,4-D) following oral administration to man. Toxicology 8, 3--11.
41.
Sepplinen, A ., LindstrOm, K ., and Manelin, T. (1980). Neurophysiological and .psychological pic ture of solvent poisoning. Amer. J. Ind. Med. 1, 31-42.
42. Sepplinen, A. M ,, Hemberg, S., and Kock, B. (1979). Relationship between bltwttlead levels and
nerve conduction velocities. Neurotoxicology 1(2), 313 --332.
43. Sepplinen, A. M ., Husman, K ., and Martenson, C. (1978). Neurophysiological efeas of long-term exposure to a mixrure of organic solvents. Scand. J. Work Environ. H ealth 4,304--314.
44.
Suskind. R. R. (1953). "Reports on Clinical and Environmental Surveys." Momsaeo,Chemical Co., Nitro, West Virginia. Department of Environmental Health, University of CiananatiGollege of
Medicine.
o. Takeuchi, Y., Ono, Y., Hisanaga, N ., Kitoh, J., and Sugiura, Y. (1980). A comparative study on the neurotoxicity of /j-pentane, /i-hexane, and /i-heptane in the rat. Brit. J. Ind. M ed. 37, 241--247.
46. Thomas, P. (1980). The peripheral nervous system as a target for toxic substances. In (P. Spencer and H. Schaumberg, Eds.)." Experimental and Clinical Neurotoxicology" Williams & Wilkins, Balti more.
47. Todd, R. (1962). A case study o f 2-4-D intoxication. J. Iowa M ed. Soc. 52, 663-664. 48. U .S. Environmental Protection Agency (1978). Rebuttal presumption against registration and con
tinued registration of pesticide products containing 2,4,5-T. Fed. Reg. 43(78), 17116--17157, April 21, 1978. 49. Valciukas, J., and Lilis, R. (1980). Psychometric techniques in environmental research. Environ. R es. 21, 275- 297. 50. Wallis, W. E., Van Poznak. A ., .and Plum, F. (1970). Generalized muscle stiffness, fasciculations, and myokymia of peripheral nerve origin. Arch. Neurol. 22, 430--439. 51. Way, J. M. (1969). Toxicity and hazards to man, domestic animals, and wildlife from some commonly used auxin herbicides. Residue Rev. 26 37--62. 52. Young, A. L., Galcagni. J. A ., Thaiken. C. E., et al. (1978). "The Toxicology, Environmental Fate, and Human Risk o f Herbicide Orange and its Associated Dioxin." OEHL TR-78-92. USAJF Occupational and Environmental Health Laboratory, Brooks Air Force Base, Texas, October, 1978.
13620
environmental research 29. 2 9 7 -3 1 1 ( 1982)
Nerve Conduction Velocity Studies of Workers Employed in the Manufacture of Phenoxy Herbicides
Raym ond Sin g er, Marion Moses, Jos Valciukas. Ruth L iu s , and Irving J. Se u k o ff
EnvironOmneentGalusStcaiveencLe.sLLeavbyoPrlaatcoer.y,NMewouYnotrSk.inNaeiwScYhoorokl 1o0f02M9edicine. Received June 24, 1981
oteu(ss(mde20ulxpfuome..rCposr14waaauonp9.ols5terseunina-dsvuorrTdllesarneou)rentvdwv0uceeoa.etrtiril9ifonennvoo1(dgeecmna,5nmin6twPcee2vydopau.eaw4nl(n<rlsworo-ooddy=sctre=u0oiekmirc.ctxee30eiht-eeni34ir0lcnotss).or.0i.tna4(rneaNonvDmw0gvtpssChe.uaepfhn4ePsoVrlleoa0tornss)tc7.m<y.1uioiooetrxyeyW0dnfmadye,.lt0a/ohihst(nv0raeofe-es4ecn2t.ecrme)Zhm..s.tT2ecuiePAcvpo1hdsmalmeli<oatal5voaucypn%csn0geimaodu.smer-0noetfe0(2ht(aonfdmr2.)ectot5.t,orte4hlw2u.Awra-e,r,g4DinlaetlmrP6csh)ov%oo=.esuancf<diplM0ogoti2ura,nn0feo,cen4i.tsstlao0frh.tinso50nawgcee0ln-sarsneatsi1odnr,srgts)uiatuetoeclespradyhrltddnoyyhwlPcdow,edoaogrnaesi<fmorrnnvorap2gd3eeiud0h5a5ldp.jsatewi0uiustnayoh0esaurnoena1tasdbexad)imjd.ry=wnensocoofeiantottta1rcsheeov)rned,reodawtswisnlgrcioienemhtwmwhraeaevotoctirnhanreiureeddnegest
INTRODUCTION
The phenoxyaliphatic acid herbicides 2,4.5-trichlorophenoxyacetic acid
(2,4,5-T) and 2,4-dichlorophenoxyacetic acid (2,4-D) have been widely used in
maintenance of right of ways and in forest, range, and crop management for over
30 years. These compounds are readily metabolized and excreted (Kohli et al.,
1974; Sauerhoff et al., 1977) and their acute mammalian toxicity is low. The LD,0
of 2,4.5-T is reported to be 300 and 100 mg/kg in the rat and dog, respectively, and
that of 2.4-D ranges from 300 to 1000 mg/kg in rats, guinea pigs, and rabbits
(Herbicide Handbook, 1979). However, during the manufacture of these her
bicides undesirable byproducts such as chlorinated dioxins have been found to
contaminate the final products. 2.3,7,8-Tetrachlorodibenzo-p-dioxin (2,3,7.8-
TCDD), which contaminates 2,4.5-T, is thought to be the most toxic contami
nant. 2.3,7,8-TCDD has an carcinogen and teratogen in
LveDry50loofw0d.6oseigs/k(Hg uinfftehteagl.u, in1e9a80p).ig2,a4n-Dd
is an may
animal also be
wcoanstanmotinfaotuenddwinith2,c4h-Dlor(iNnaotresdtrodmioxeitnsa.l.H. o1w97e9v)e. rR, etcheenhtliyghsloymtoexCican2a,3d,i7a,n8-TfoCrmDuD
lraatnioenest oafl.,2,41-9D80)h.ave been found to be contaminated with 1,3,6,8-TCDD (Coch
A 1:1 combination of the n-butyl esters of 2,4,5-T and 2,4-D comprised Agent
Otora1n97g0e,(Ya oduefnogliearnat lw.,id1e9l7y8)u.sIend 1b9y71th, ethUe .US..Sm. iElitnavriyroinnmSoenuttahl VPireottneacmtiofnroAmge1n9c6y5
suspended most food crop uses of 2.4,5-T and most other uses were suspended in
297 0CA0ollp1ry3igr-ihg9ths3to5(f01r/e81p928ro/20db6uyc0tA2io9cna7di-ne1ma5niScy0Pf2ore.r0mss0./r0eInsce.rved.
298 SINGER ET AL. 1978 based upon unresolved questions regarding effects ot'low-levei exposures to chlorinated dioxins on human health (U.S. Environmental Protection Agency, 1978). 2,4,5-T is no longer being manufactured in the United States.
HUMAN HEALTH EFFECTS
There have been sure to 2,4,5-T and
many reports of its contaminants
adverse effects on human health in relation to industrial accidents
(fHfqumffeerxaplo.,
1980). The first known accident occurred in 1949 in the United States when a tri-
chlorophenol reactor exploded. Similar accidents occurred in 1952 and 1953 in Germany, in 1963 in Holland, and in 1968 in England. In 1976 an explosion oc curred at a chemical plant in northern Italy, resulting in release of a toxic cloud ohveearvitlyhecosunrtaromuinndaitnegd cwoimthm2u,3n,i7ty,8.-TECvaDcDua,twioansoofrdtheeretdow(HnoomfbSeervgeesroe,t walh.,ich19w79a)s. Health effects are also known to occur from the manufacturing process itself when oaitnovllee11rg99ee66xd28p((ioBPnslaueVzridbieeeetorrncogacvmeuatr-aVsvlei.uj,telnur1rpa9e6nkla4sot)veaadannetddro ai1anl9n.6,S4eo1x(u9pHt8lh1ao)ys.Vi,Aoi1ned9t,vn7me7ar)mo,sseaetnshnedeoaeitnlxathpbCloeyzsfeeficnedhctotthsoselhoAUavgvaneekintiaetaldsOionSrtba1aen9teg6en5es but few data are available for evaluation of the problem and it is not yet known TwChWeDthhDiel,re e2tfh,f3ee,cr7te,s8-ioTsnCnDothDepaistskhaiongf,nacolitmvoerorn,inicatnhsdeynnrdeerprovomortueesdrseeylfasfetteecdmts.tohaevxepobseuerne rteopo2r,t3e,d7,8inworkers exposed in several industrial accidents (Huff et al., 1980). A consistently reported effect has been chloracne, a refractory follicular dermatosis of varying extent and severity depending on the duration and amount of exposure. Central and peripheral nervous system effects also have been frequently reported and are reviewed below.
Ashe and Suskind (1950) examined four workers who developed chloracne fol
lowing exposure to the contents of an overheated reactor accidently released in 1949 during the manufacture of trichlorophenol for the production of 2,4,5-T. Irri tability, nervousness, insomnia, loss of libido, and impotence were reported. Stryemmpittioems.sHoifstpoepraipthhoerloagl inceeuxraompainthaytioinncloufdseedvepraainl samndallwceuatkanneesosuisnntherevleoswienroenxe case showed destruction of myelin sheaths and nerve fibers with replacement by connective tissue. In a follow-up study (Suskind, 1953) of 11 affected workers eaxrepao,s3e5d oaft wthheom194h9aadcschidoewnnt cahnldor2a5canfef.ecstyemdpwtoomrkserosf fpreormiphtheera2l,n4.e5u-rToppartohdyucwtieorne found in 27 cases. Fatigue, nervousness, irritability, and decreased libido were alsBoafuoeurnedt. al. (1961) studied workers who had developed chloracne while em ployed in the manufacture of 2,4,5-T. Fatigue, muscle weakness, and pain, mostly in the lower extremities, were prevalent symptoms. Paresthesia and hyperesthesia (dseefnicsiotrsy, dneecurreoapseadthdyr)ivwee, rientofoleurnadn,ceastowaellclohasolinanabdilsilteyeptodicsotnucrbenatnrcaetse,, inmcelumdoinrgy increased somnolence.
13622
NCV AND exposure to phenoxy herbicide
299
Poland et al. (1971) studied 73 current employees at a 2,4,5-T and 2.4-D man
ufacturing plant. 13 of whom had chloracne. An increased prevalence of
neurological findings was not reported. A positive correlation between severity of
chloracne and score on the hypomania scale of the Minnesota Multiphasic Per
sonality Inventory was found.
Kleu and Goltz (1971) conducted a follow-up study of ten workers acutely
exposed to TCDD 15 years earlier and reported fatigue, muscle weakness, de
creGaosleddmlaibnindo(1, 9a7l2c)ohstouldiinetdol4e2rawnocrek, earnsdinmvoemlvoerdyinloasns.accidental venting of steam
dceunrPtianrzagdl tenhreeorvmvao-auVnsiujsflauycspttkueomrvea(oCeftNtraSilc).hi(ln1o9vr8oo1lpv)heeemxnaeonml.tiSnaenevdden5th5rseohefowo80fedpwosoliyrgknneesrusorroepmsayptmhloypy.teodmsatoaf
pexlaanmt imneadnudfuarcitnugritnhge2y,4ea,5r-sT1w96h7otowe1r9e73e.xpPoesreipdhefrroaml n1e9r6v5ouths rsoyusgthem19i6n8voanlvdemweenret
was indicated by symptoms such as muscle weakness and pain in the lower ex
tremities. Abnormal nerve conduction velocities were found in 17 cases (31%).
Mild Schwann ceil pathology was found at autopsy in the most severely affected
worker. CNS effects were indicated by symptoms such as fatigue, sleep disorders,
headache, and sexual dysfunction. Abnormal electroencephalographic responses
were found in 27% of 34 cases examined, with borderline findings in an additional
21%. On the basis of severity of CNS symptoms, a subsample of 36 workers were
esxivaBemo."einriedet
by a psychiatrist, who characterized al. (1978) utilized nerve conduction
35 as "neurasthenic" velocity to assess the
or "depres presence of
possible neurophysiologic dysfunction resulting from chemical exposure as
sociated with the Seveso accident. They compared two groups which differed in
degree of TCDD contamination: 470 from the more contaminated zone and 152
fmroemasutrheed.zoAnerealattilvoewlyerhrigishk.prNeCvaVlenocfethoef aublnnaorrmanadlitipeesrwonaesalfomunodtoirn nbeortvhespowpaus
lations (19.8 versus 13.2%). The authors attributed the increased prevalence in
pasasnoctioattehde wpritihor tehxepoinsudruestroifesthoeflethsse haeraeva:ilyweoxopdowsoedrkipnogp,ulmateitoanlwtoorkchinegm, icaanlds
chemical industries. Still, a greater prevalence of polyneuropathy was found in the
group living closer to the site of the accident.
In a follow-up examination of the Seveso population (Boeri, 1980) a subgroup of
the exposed population (N = 277) was compared with residents of an unexposed
ctnforooewnqodnutuheGcenVtrcioye=ntoiof3vl8poe0eglo)rycifpi(othsryuercswiahglanansssemudanrieaodabpsesauyttrehmesyd)pcwtoooanmuslsdtfhoobuefenupdfloenirunainprtdhha.eenrASadlesvipngeeensruioofrinocpepaoanaplttuhlnylyae.gtrirvMoeenasot.fteoorArrpwnr4ehe.5rvic%vahe
lence of peripheral neuropathy was found in the Seveso population than in the
control group. Sensory nerve conduction velocities were not assessed.
pGeorAlcdusftteaewnineoreeutpsaoler. xts(p1o9as5ru9er) eafovtuaonil2da,b4sl-eeDvecruoesnecsdeernanssionargyspathrnaedym.huComtaoasrensdihosoefarndlteehurrseofipnfeatcthhtsryeeofofclal2os,we4s-iDnog.f
exposure to 2,4-D have also been reported by Todd (1962), Berkeley and Magee
300 SINGER ET AL. (1963), Berwick (1970), and Wallis et al. (1970). In all of these cases the exposure was to the already formulated product. Chloracne has not been reported with ewPxooplraoknsedurrseetotacocl.u,2r,4r1-e9Dd71. )wT. ihthe oconnlycormepiotarntst ienxwpohsiuchrechtolor2a,4c,n5e-Tha(dBlbeeibenerfgouent dali.n, 21.946-4D:
ANIMAL STUDIES
'
While there have been a large number of studies of chlorinated benzo-p-dioxins
and related compounds in nervous system. Elovaara
eetxaple.ri(m19e7n7t)aladamniimniasltse,revderay
few have focused on the single intragastric dose of
2ra,3ts,7. ,C8-rTesCoDeDt alt.o(r1a9t7s8,)afnodunfdoutnhdata2n,o3m,7,a8l-oTuCs DCDNSadfmuninctiisotenreind
some of the treated intraperitoneally or
orally in rats resulted in CNS symptoms of irritability, restlessness, and increased
aggression. Bucher (1946) and Hill and Carlisle (1947) found that mice, rats, rab
bits, guinea pigs, and monkeys exposed to 2,4-D could develop myotonia, motor
disorders, and paralysis of extremities. Desi et al. (1962) found that parenteral
administration of 2.4-D in rats resulted in electroencephalographic abnormalities
and decrements of rat performance, associated with pathology in the spinal cord.
Elo and Ylitalo (1979) and Way (1969) presented additional histological evidence
of nervous system susceptibility to 2,4-D.
NERVE CONDUCTION VELOCITY
Nerve conduction velocity (NCV) assessment has been used by many inves tigators in studies of toxic agents such as lead, mercury, and solvents (Spencer and Schaumberg, 1980: Seppalhlinen et al.. 1978, 1979, 1980; Buiatti et al., 1978). Buchthai et al. (1975) and Behse and Buchthal (1978) have studied the association of slowed NCV with symptoms of neuropathy and histological findings and pro vide evidence concerning the importance of electrodiagnosis in the evaluation of toxic neuropathies. NCV measurement is well suited for epidemiological studies since (T) the technique is noninvasive. (2) it can be performed quickly and accu rately on large numbers of people, and (3) the results are quantitative (in continual and can be related to other quantitative, continuous variables such as duration of exposure or biological indicators of exposure when available.
An important aspect of NCV assessment is its sensitivity to toxic changes before other signs or symptoms are present. When rats are injected with a nneeuurrooptoaxthicy asguecnht asus cwheaaskne-hssexaannde.paNrCalVysissloawpipnegaris(Tfoaukneducbheifoerteals.i,gn1s98o0f).ovPerretsymptomatic NCV slowing is also found among diabetics before symptoms or other signs of neuropathy (Thomas, 1980). Since NCV slowing is an early indi cator of neuropathy, measurement of NCV is being used increasingly to assess subclinical dysfunction in studies of environmental and occupational toxic expo sures.
PRESENT STUDY
In April 1979, chlorinated dibenzo-p-dioxin contamination was found in loca tions away from a chemical plant producing 2,4,5-T and 2.4-D in Jacksonville.
1362
NCV AND EXPOSURE TO PHENOXY HERBICIDE
301
Arkansas, a small community near Little Rock. The source of the contamination was found to be toxic wastes leaking from drums stored above ground at the 93-acre plant site. Levels of 40 ppm of 2,3,7,8-TCDD were found in the wastes and 2 ppb in a sewer system outlet at the plant that discharged into the city system. The problem was investigated by the Arkansas State Department of Health, and the Governor's office ordered production of 2,4,5-T suspended until the health and safety implications of the findings were investigated and evaluated. ^,4,-D, however, continued to be produced.
2,4,5-T and 2,4-D had been produced at this plant since 1957. In the late 1960s more than 14 million pounds of Agent Orange (a 1:1 combination of the n-butyi ester of 2,4,5-T and 2,4-D) were manufactured at this site. Phenoxy herbicides had been the exclusive product of this plant since 1971, when the manufacture of other orgInan1ic97a4ctidhehreerwbiacsidaesrewacatsordiascccoindteinnut eddu.ring the manufacture of trichlorophenoi resulting in an outbreak of chloracne in the crew assigned to do the cleanup. Except for this episode, which involved fewer than a dozen workers, chloracne had not been a serious problem at this facility.
In July 1979, at the request of the Arkansas State Health Department, a health survey of current and former workers at this plant was conducted by the Envi ronmental Sciences Laboratory of the Mount Sinai School of Medicine. While 2,4,5-T production had ceased at the plant in April, nonetheless, some workers were involved in redrumming of contaminated wastes in leaking drums. All work ers were exposed to 2,4-D which was still being produced.
METHODS
Subjects. During July 1979 a health survey was conducted of 190 active, retired, and former workers of the piant. All 88 current workers were invited to participate and 76 did so, representing 86% of the active work force. Workers were included for NCV assessment if no positive history of diabetes, neurological disease, or excess alcohol consumption was found in the screening interview. Because of time limitations, NCV was measured in only 55 of these workers (53 active, 2 retirees).
All workers were at risk for exposure to phenoxy herbicides to some degree. Subjects were interviewed regarding exposure to other toxic chemicals, since some of these might affect NCV. Concurrent exposure to other neurotoxic agents was not found in any of the workers studied. Nine workers were found to have had possibly significant prior exposure to such agents, which included pesticides, solvents, and--in two workers--2,4-D.
The original protocol included examination of workers who had had minimal or no direct exposure to 2,4,5-T or 2,4-D. However, due to time limitations, this was onfotthdeonined. iTvihdeueallescutrbojpechtyss. iologic team remained unaware of the exposure history 8 bTrhaekecownotrrkolergsroeuxpamcoinnesdistaesdpoafrt17ofEanvsuirrovnemy eonftaalsbSecsietonsc-eesxpLoasbeodrawtoorrykesrtsaf(fNan--d 25). All subjects were screened prior to testing for exposure to neurotoxic agents, history of diabetes, stroke, other neurological disease, and alcohol use. No con-
13625
302 SINGER ET AL.
trol subject had significant exposure to neurotoxic agents. Control subjects were excluded if alcohol consumption exceeded four drinks per day. Exposed workers cwoemrepuintteedr.vOiewnleydlicmonbcsetrhnaitnghaadlcsouhfofel ruesde annodsiagnniinfidceaxntotfrwauemekalywceornestuemstpedti.onIfwthaes back had been injured, or if disk disease or "sciatica" were reported, the subject's sural nerve velocity was not measured. weCreonadsusecstisoend.vMeloedciiatinesmooftothrevemloecdiitayn wmaostomre, amsuerdeidaninse5n3 scoarsye,s aanndds2il5raclonnterrovless; median sensory velocity in 54 cases and 23 controls; and sural sensory velocity in 50 cases and 20 controls. All stimulation was supramaximal. Sensory stimulation was antidromic. Latency was measured in the motor nerves at the first point of mhniesegtaaostruiyvr.eemdeenfltecwtiaosn,caonnddfuocrtethde wseinthsoouryt aktntohwe lpeedagke noefgatthievesduebfjleecctti'osne.mWpalovyemfoernmt
The recording electrode for the median motor nerve was affixed at the center of the thenar eminence over the adductor pollicis brevis, and the reference electrode ringed its tendon of insertion at the thumb. The nerve was stimulated proximally medial to the aponeurosis musculi bicipitis brachii, and distally at the wrist be tween the palmaris longus and the flexor carpi radialis tendons. The median sen sory evoked potential was recorded using a ring electrode around the middle aminretoedurinapdnhamtihaoentgoderiaslsttajiolminiuntltaeotrifpotnhhaepiaoinningdete.axlTfjhioneignreter.c, oTarhnddeintgnheeerlverecetfreworaedsnecseftoimreletuhclatertoesuddreaalwt wathas seaafdfiirsxitneadgl electrode shaped into a strip and taped so that one end touched the lateral mal leolus and the distal end pointed toward the posterior tip of the calcaneus. The reference electrode was placed approximately 2 cm distal and parallel to the recording electrode. The stimulation site for the sural varied somewhat, since occasionally the evoked potential could not be detected without varying the stimulation site. The initial site chosen for each subject was slightly distal to the midsection of the two heads of the gastrocnemius. If the evoked potential was inadequately defined, the nerve was stimulated more distally in a fine extending from the initial stimulation site toward the recording electrode. Stimulation and recording procedures were rechecked if the sural evoked response was not elic inteevde. rTlheessdtihstaannc1e1 cbmet.ween the stimulation site and the recording etectrode was
A Teca TE42 electromyograph with digital averager was used in the field re tscheaarliorbucrhgah.tioTounhtettrhuaencietstwhuaaddsy.pbreienntecdaolinbreaatcehd EbyMtGhetrmacaen.uTfahcetuurneirt prermioarintoedthine sctaulidbyr.atTiohne apthrameSlmrkm(i)ntihasetnteodmprrappoterxrtoiwambteoualrapeaponopindflitetsdhdioesnttolailmthtshbeteimwlesaugkslia(nomtivsoeuenarrsfustaihrcteeeedss,stuuiamscnicndueglsaasattiivotRhneoelycathnhaedetsntrteaehrrcroeeEremdleipicnnotgeirnnoetc-lsMeecooetnrdfoittcdhhaeeel sitTesh)e. Tdihsetatnecmepoefrathtuerneervvaeluseesgmweernet awvaesraagsesedssfoerd euascinhglifmlebx.ible myfar measuring tape. The shortest distance between the points was followed, and the tape mea-
NCV AND EXPOSURE TO PHENOXY HERBICIDE
303
sure was in contact with the skin at ail points along the surface of the tape measure. Care was taken not to stretch the skin by pressing too hard on the tape measure. Nor was the distance shortened by pulling the tape measure so that cowonanstthaaecctcaewcptitutahabltlheceafolscrkuiilnnattewiora-nrsaoltoefrsttrh. ee(lRiaNebClialVittiyvf,eolayr pasrhogocirevtdedunirsentaecrnovcneed.s)uccAatenddhiofafnevreheanalcfleathrogeefcae1fsfmeescm.t
A Disa 1500 electromyographic system was used for the examination of some of the control subjects. Since it was possible that the two units might not be measur Einngviirnoncomnecnotradl aSncciee,nbceosthLuanbiotsrawtoerrye. cNominpeasruedralu,sitnwgo vmoleudnitaenermsoutbojre,ctasndat otnhee median sensory nerves were used. Each nerve was examined using both the Teca and Disa units, utilizing their respective recording electrodes. The units had been recently calibrated by the manufacturer, and the calibrations were frequently checked. The Teca stimulating electrode was used throughout the study, since in fdoerntmatairoknisngretmheaipnotienmtspoofrasrtiilmyuolnattihone.suTrhfeacceoorrfetlhaetioskninb--etwtheisenistmheorme ecaosnuvreenmieenntt of the two units, using the same points of stimulation and pickup, was calculated to be +0.97, .P < 0.0001. Therefore, the two units were measuring evoked potentials in concordance.
ANALYSIS
In this group, chloracne was infrequent and could not serve as a variable in the
anLaliymsbis.temperature. Nerve conduction velocity is affected by temperature at the
a1p97p3r;oxHimalaatre ert aatel.,o f19280m)./sLeci/mCb
(tGemopoedrgaotludreanisd aEfbuenrcsttieoinn,
o1f9m78a;ndyevJaersiuabs leets
al., not
related to exposure to neurotoxic agents, such as room temperature, outdoor
temperature, the amount of clothing worn, blood circulation, and the subject's
age. Limb temperature can vary to the extent that interpretation of significant
differences between two groups can be compromised; a mean temperature differ
ence of only 2C could lead to false conclusions concerning true group differences.
To reduce the variance produced by temperature on nerve conduction velocity,
some investigators warm the limb to a standard temperature. However, this is not
a practical is limited.
technique in An approach
the field when many subjects must be currently used by some investigators
(eHxaamlairneetdaaln.,d 1t9im80e;
de Jesus et al., 1973) is the mathematical adjustment of all velocities to that
expected at a standard temperature. The equations were derived from experi
smeenntetadl bmyadneipJuelsautisonet oafl.li(m19b73t)emwpeerreautuserde iinn tthhies slatubdoryattoorayd.juTshteeaecqhuavteioloncsitpyrteo
36C (Appendix A). This temperature was chosen following the approach of
R35o-s3e7nfCal.k (1975), who reported norms based upon the heating of limbs to
Age. Nerve conduction velocity declines with age at the approximate rate of 1.5
m/sec/decade depending upon the nerve examined (Behse and Buchthal, 1971;
Nielsen, 1973; Rosenfalk. 1975; Buchthal et al., 1975). Investigators who have
considered the effect of age upon nerve conduction velocity usually attempt to
13623j
304 SINGER ET AL.
match each subject with an appropriate control when comparing two groups.
However, under some circumstances the appropriate control data may not be
available. An additional shortcoming of the matching procedure is that the control
data are based upon a single observation. Assuming linearity of the age effect
upon conduction velocity, a regression equation can be constructed which is
basInedaurpeocnenmt asntuyddyatoafploeaindt-se,xtphoasteids. waollrskuebrsje, cBtsuicnhtthhaei daantda pBoeohls.e (1979) used
regression equations to determine the expected nerve conduction velocity of a
theoretical matched control. The mean difference in velocity between the subjects
oanf dthtehedirfefegrreensscieonb-eptrwoedeuncetdhe"gmroautcphsedwacsonetvraollu"atwedaswciatlhcutlhaetetdt.eTsthfeorsigconrifrieclaantecde
meZa-nssc.ore standardization. The Z-score transformation is widely used when com
paring values from distributions with different means and standard deviations,
sdienvcieataioftneroftroannesf(oArmnaasttiaosni,th1e97d6;istVriablcuituioknass ahnadveLailims,ea1n980o)f. zTehrois atrnadnsafosrtamnadtaiordn
can be applied to reduce the contribution of confounding variables, such as age,
boyfAcdolelntcefoornmudniundciinntiggontvhaveredilaoebpclaietrsyt.uvraeluoefsawn eorbesecrovnevdervtaelduetofrZomvatluheast
expected on in this study
the by
basis using
the equation
observed velocity - velocity predicted on the basis of age the standard error of estimate
The velocity predicted presented by Buchthai
oent
athi.e
basis of age is (1975) for the
derived sensory
from the regression equations nerves and by Nielsen (1973)
for the median motor. Velocity was adjusted to that expected at 36C, as discussed
above (Appendix A).
The study and control groups were compared in two ways: prevalence of
slowed nerve conduction velocities and comparison of means. The study group
was further analyzed by examining velocity as a function of duration of employ
ment. A Z value corresponding with the 0.01 (one-tailed test) or less probability
level was designated as a slowed value.
RESULTS
tioFnovretylo-sciixtiepse,rvceernstusof5%theofstthuedycognrtoruopl ghroaudpo(nxe2
=or1m7.o1,reP
slowed nerve conduc < 0.001). Twenty-four
of the 50 sural nerves measured fell below the first percentile, control sural nerves, using the equation presented by Buchthai
veet rasiu.s(129o75f )t.hOe n2e0
subject's sural nerve evoked potential was absent.
The effect of alcohol on nerve conduction velocity within the study group was
examined. In general, alcohol consumption was low, averaging 2.7 drinks per
week. There was no difference {P < 0.39) in the alcohol consumption of those
subjects with a slowed velocity when compared with that of subjects with nor
mal velocities. The correlation of reported alcohol consumption and nerve con-
NCV AND e x po su r e t o ph e n o x y h e r b ic id e
305
duction velocity in the three nerves was not significantly different from zero. Therefore, the effect of alcohol consumption is unlikely to have produced the obTsearbvleed1gprroeuspendtisfftehreenr-cteess.t analyses of theZ scores of the study versus control populations.
The probability of a one-tailed r value is shown, since the study group is hypothesized to have slower velocities than the control group. The meat} vel ocities of the median motor and sural sensory nerves were significantly slower in the study group than in the control group. (The nerve conduction velocity values before the adjustment for age and temperature are presented in Appendix B.)
The mean sural velocity Z value of the study group is approximately 1.3 stan dwaitrhd ademveiaatniosnlouwninitgs bofelaopwprtohxaitmoafttehlye 5co.2ntnrvo'lsegcr.oFuopr. tThheismdeidfifaenremncoetocronrreersvpeo,nthdes meAanddviteilooncaitlyr-stleoswt ianngawlyassesapwperroexcimonadteulcyte1d.9wmit/hsecth. e study population reduced by removing eight individuals who reported consuming more than 28 alcoholic dthreinrkstepstesr awreeepkr. eAselsnoterdeminoTveadblewa2s. the one case of mild diabetes. The results of
The mean velocities of the median motor and sural sensory nerves were still significantly slower in the study group than in the control group, suggesting that the slowed velocities were not due to consumption of alcoholic beverages. n(--ae0gAre.v4e0caoc,norPdrned<tlaeumt0ci.top0ino0enr4ca)vo,tueewlrfofheicicliaietedyntjhwutesawtvseadehsl)oigccwhiotlimyitehcpsoudmrtureeredaalsatutitooerndeadwsosiifnethsetshmdeutphrmleaoetyiadmosinaseonnoctfmiae(omtTitooapnrblolaeyonmfd3ve)m.nelteSod(ucriirata=nyl senFsuorrtyhewrerr-etenstotancoarlyresleastewderweithpedrfuorramtieodn aoffteermrpelmoyomvienngt.the nine workers with
TABLE I
Mean N erve Co n d u c tio n Velo cities o f Stu d y Versus C on tro l G roups'*
Nerve
Group S ZMveaalnue SD
r Prob, t (one-tailed)
Median motor
SCtoundtyrol
53 25
00..2901
1.19 1.89 1.70
0.03
Median sensory SCtoundtyrol 5242 --00..1064
01..8151 0.52
0.30
Sural
SCtoundtyrol 5200 --20..2512
11..0692 4.28
0.0001
the" tBeamsepderautpuorne Zcovrraelucteesdwohbiscehrvreepdrevseelonctitthye, dvievliodceidtybeyxtpheectsetdanodnartdhedebvaisaitsioonf. age subtracted from
306 SINGER ET AL.
TABLE 2
Mean Nerve Conduction Velocities of Study Versus Control Groups"
Nerve
Group .V ZMveaalune SD
t Prob, t (one-tailed)
Median motor
SCtoundtyrol
44 25
00..9218
11..2062 1.77
0.04
Median sensory SCtoundtyrol 4253 --00..1004
01..8151 0.22
0.41
Sural
Study 41 -2.17 1.04 4.13
0.0002
Control 20 -0.52 1.62
wdthihea"obtBeectmaeossnpesdewurameurtpueeordneremZcmooorvrvreaeelcutdhteeafsdrnowom2hb8iscteahhlrecvsroeeehdpoarlvneieacsleloybncseteivtstyeh.,readgvievesildopecdeitrybwyeextehpkeec(stNteadn=doan8r)dthadenedbvaitashtieisoonon.feTaghseeubsdjuaebtcattraowcfittsehudbsjfleriogchmtst
pddioudsrsanitboioltynafsafilgescnotifwtihcaaesnpterspesrveiinoortuiaeslxlfpyinodtshuinergessatm(oTenabe(ruler=o4t)o.-0xTi.ch4e2a,gceoPnrrt=se.la0Rt.i0eo0mn6o)o.vfasluoraf lthNeCseVcawsieths It was possible that a residual effect of age upon sural NCV remained after the
standardization process. Such an etfect could have spuriously increased the cor relation between NCV and duration of employment. This possibility was explored by computing the partial correlation of sural NCV (standardized) with duration of ee-xm0pI.pn3ol2sotu,hyremPeoerwn<yit,t,h0tch.0soeu3nr)vt,aralorsliNulaipnCnpgcVoerf.otoirnf gasugtreha.elAvperslieogvcniioitfyuicsaclyanntdrebeselcarbtiibeotentdesrhnipmegowadtaeisvleedstcialolsrfroaeulfanutdniocn(trioo=nf of age. skin temperature, and duration of exposure, without using statistical parameters derived from calculations based upon other samples. Such a model is expected to reflect more accurately the partial correlation of the dependent vthaeriastbuldesy wsiatmhipnleth. iTs hsaismmploedseilnwceasthteesptaerdambyetecrosmapruetibnagsetdheupmounltvipalreiactioornrewlaittihoinn oveflaogceit,ys.kin temperature, and duration of employment with unstandardized sural
TABLE 3
Years of Employment Versus N erve Conduction Velocity Adjusted for ace and T emperature
Median motor
Median sensory
Sural
Npr
-0.04 05.830
-00.5.14408 -00.5.40000
Note. Mean years of employment = 7.0. standard deviation = 6.2. range = 1-28 >ars.
13630
NCV a n d e x po s u r e to ph en o x y h e r b ic id e
307
TABLE 4
Mean Nerve Conduction Velocities of Study Versus Control Groups"
Nerve
Group V ZMveaalune SD
i
(onPer-otabi,letd)
Median motor
SCtoundtyrol 4245
00..1912
11..1072 2.29
0.01
Median sensory Study Control
44 23
-00.2.034
01..8016
1.01
0.15
Sural
SCtoundtyrol 4210 --20..1512
11..1672 4.58
0.0001
tphoe"sstBiebamlsyepdseirguanptuiofrniecaZcnotvrparelruecevtesidowuoshbiecsxehprvroeespdurreveseetlonotcnittehyue,rodvtieovlxiodicceidtaygbeeyxnpttsheecwtesetdraenodrneamrtdhoevdebedav.siaistioonf.agNeinseubsturbajcetcetds fwroimth
The multiple correlation coefficient was computed to be 0.52 (P < 0.002), which
exceeded the (as described
caobrroevlea,tiron=of-d0u.4ra0t.ioPn
of <
e0m.0p4l)o. yTmheentt
and standardized sural NCV test for difference between
vc2oi.d0r8erd.elPabtee<tdterr0'.s0ti5ts)hf.oorAwstehdeexstepheadctatttehad.e, WctohhrereenmlacotodiomenlpuacrosiiennfggficutihneensttrasenlddaitafirfvederiezcdeodnstisrguinbriauflitcioNannCtolVyf a(p/greo=,
skin temperature, and duration of employment to the multiple correlation coef ficient. it was found that the variable contributing most to the correlation coeffi
Tciheentpwaratsiadlucroartrioenlaotifoenmopflosuyrmael nNt C(aVccowuitnhtindgurfaotrio8n3%ofoefmthpelotoytmalesnutminotfhsiqsumaroedse).l
was essentially the same as that found when correlating standardized sural NCV
with duration of employment.
DISCUSSION
An increased prevalence of slowed nerve conduction velocities was found among chemical workers exposed to the phenoxy herbicides 2,4,5-T and 2.4-D and related contaminants (chlorinated dioxins). Conduction velocities of the me dian motor and sural sensory nerves were significantly slower in the study versus the control group. Slowed sural sensory velocity was significantly correlated with duration of employment.
The sural nerve seemed to be especially affected in this study. In other studies, stomxaicllesrunsceerpvteibdiilaitmyeotefrn(eTuhroonmsahsa, s1b98e0e)n. Sasinsocceitahteedcewnittehrionfcrneeausreodnfmibeetralbeonlgisthmafnodr the sural nerve can reside over a meter from the axon site, and the fibers are few, have smaller diameter, and less myeiination, the sural nerve may be especially vulnerable to disruption of normal nervous tissue metabolism and function. resOptohnesrerienssetaurdciheesros fhbaovteh ainlcdoichaotledtoxthiceitiymapnodrtpaonlcyeneoufroapssaetshsyinogf vthaeriesdureatlionloegrvye. Behse and Buchthal (1978) found, in a study of 167 patients with polyneuropathy
308 SINGER ET AL. of varied etiology, that abnormal electrophysiologic responses were more fre qsfouuuperenrtmfiiocntiaotlrhepaensrduorntawelaonl sewernverseoerthsyiamnnieliranvre.t)sheDw'imAthemdtohiauenrsuseertnaalslo.Nr(Cy1.V97(F9in)inacdolicmnoghpsoalriinecdtshutehbejseuNcrtaCsl,Vaannoddf found that abnormalities of the sural nerve were most likely to be detected.
Although the dioxins are known to be highly toxic, the significant findings here may also be due to 2,4-D exposure. This possibility is being investigated by studies of another group of workers who had been exposed to 2,4,5-T (contami nated with dioxins) but not exposed to 2,4-D. raiIsnedadredgitairodnintgoeoncvciuropnamtioennatall epxrpeosseunrcee, oifmtphoersetacnht epmuibclaicls.hMeaultchh qpuuebslticiodnesbaartee and concern was evident among the citizens of Arkansas in response to the toxic bwyastthee perpoibsoledme iant StheeveJsaoc,ksIotanlvyi.llEeaprllayndt,etwechtiiloenwoofrladdwviedresecohneacletrhnewffaesctssticmaunlahteeldp to provide guidance concerning implementation of preventive and control mea sures. Since slowed nerve conduction velocity can be an important early indicator of toxic exposure, the study of the relationship of such signs of neurological im pairment to adverse effects in other body systems, either concomitant or delayed, remains an important clinical and scientific endeavor.
APPENDIX A. EQUATIONS FOR TEMPERATURE AND AGE
VVMVMSMSSTTT === VVVMMSSMSxxx((iff*-01* *" <), VVVZMZMMZSMMSSSMSSPPP ==-=== ((565(VVV799...MSM545SMS--T-(T-T0((V-0-0.VV1S..01MS5M58PSMxVxxPPV3aaa.Vggg47eee.,36))).,.,.4, where VVVVVVMVZMVMZMMVSMZSMMMMSSSSSSMMTTTPSSSSPP ============ vvvvvvsvvvsstteteeeeeeeeaaalllllllllnononooooooodccddccccccciiiaiiaaiiiitttttttttrrryyyyyyyyydddiiismmsmmmmszzzuuueeeeeeeeerrrdddddaddddaaliilliiiiaamsaamaatoupnnnnnneeebrrmddaesmsmsmsledeiieepaaoononnirevnnctvsttssreootooooeaeslmrrrrdrrotdeyuyyo.tpconerobirtsteoptmoeneosybrrdemar,pesytridvdehceavpjreitegreuevceavledrseotdtbeaeut.lcaaedotdroiunsd,ectntyrdo.iset,anyttdohaa,ejtfegdmhuaeajegsbupgteaaesebenstdr.aaeida.snsdttdu.tsoerftemoeafmpagadeepgjr,euaer,stautetruder.eadajdujsutestde.d.
NCV AND EXPOSURE TO PHENOXY HERBICIDE
309
APPENDIX B. MEAN NERVE CONDUCTION VELOCITIES (m/sec) OF STUDY VERSUS CONTROL GROUPS
Nerve Median motor
Group N Age VMeleoacnity SD
Study Control
5235
3342..38
5577..06
35..2260
t Pa 0.56 0.29
Median sensory SCtoundtyrol 5243 3347..42 4476..88 54..3467 0.81 0.21
Sural4 SCtoundtyrol 5200 3440..01 4402..38 34..4980 *" TOhnee-ctoainletrdoltsesatr.e significantly older for the comparison of sural NCV.
2.05 0.02
ACKNOWLEDGMENTS
We wish to express our thanks to Robert Whipple, Albert Einstein College of Medicine. New York City, for his most generous and expert guidance. We thank David Nicholson and Michael Moses for their daYthniloedirgirkebcnyCot fnoaetmslislnopiusuwittnasingnhcgipseuCdspeuupnproitpnretogrritnathnfcerdoodmmtahtpeaturacDteionerliplnoeacgprtetigmroarneatinnopttnhSosa.sfTeFB.3u2iWonsEdeteSaadt0liss7iotn0ic1wps0a.i-s0rhtM3.btooyutnahtaNnSIkiEnatHhi eSSCcchietonyoteUlrongifvraMenrsteid(tyEicSion0fe0N,92ef8ow)r
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13633
310 SINGER ET AL.
BuchSeorc,. NE.xpL.. BRi.ol(.19M46e)d.. E6f3f.ec2t0s4o-2f025.4. -dichlorophenoxyacetic acid on experimental animals. Proc. BuchJt.hianl.d.FM., eandd. 3B6e,h1se3.5F-1.4(71.979). Electrophysiology and nerve biopsy in men exposed to lead. Brit. CBCBouruecciashhpBtIfo4ctthrtno-l4h.riaeidr.i2annEmt"il.i-eoEEP.c.u.J,x4ane.Fl.,il6WDvran.i4I,tiCapseenr..n.Roh.dedSMdncePo.SapcmrsraieMaurheenrloelnnisiegennndedfchNdioatunte..,.rl.ctercoeJsRtSu3Vksmd..r.5,o...ooP,y,amAMpftohRD1ea.gi2ti,o6.lhtolr.ahen8a4aenOdsync-p-a.e1hwcdd"hil7etiWipioo.c(lBc3hlPrhbi..0kei...lefahos.ir.JLn.hWsr.oed2o..D2.ipaDpnkha-FoygneIe.l2scmfadn(k4or1oap.a.rP9nxda.Pa17dyc,g95.Pt8i)Bae.nKo.0,cx.i.fS.,e.paCteoTGanincnhsdh.sudloaoo(rB1mcerrS9iyiudnac7tlsoaopg8f,ttao)oets.rat.rdoeenElTlntdlvhDfit.f.eieieaE(notGl1p.txts9esr.iHeo.8nns(0f.sI1ee)nn9aL.nuon7scraAro8hdemm)pno.RobsaaeiflleRecyarclaoesatnhn.filtdsaadleEotrdimolrddoeifiCn(snaas.tasecto)ehhtao.mceeislVhpdoerpnsgoowdbiilucnic.eobnaietrel1dwrkd.nvsaeeezepnreolosplsdnna.-.. CDr'oAwmTfr,CooKmuD.rD,cDh.M.lBo(.1omL9ll7a...0pS)Sh.othChca.ahhlIlaeotnn.rteaS,cpRanen.erd..RAp.5i4Yctc,r.hi,1tia5fcnu9adml2-reB1es5vi.r9ideT6,wr.aKnin.sc.Tlu.Sdt(.1in9Jg7o9ha)n.csoTmHhepoasirmpi.spoDonretoramfntcawetoool.sfeSsrtoiuecds.yoi5nf6cg.a7ssue9rs-a9ol9fn.aecrnvee dDEGEeIleoooslJ.vide,cAPodnsamsHoyiefrhaIucnscra.ra.2h,svtanhdre..Ale.n.S3umom,P..coErEc,7aot.so.Pn,icip.,8naoVn.vohn-SnJdilJt.tred..a,e.uh,oanvtceJn1n(roSYoti1ar8d.irxlu.9co.la.yHi7lthlni3teoaa2naHl.e.txoc)loeea.oaeirFnfclo.utrtS..iihehds,tccPysHumihabp..4ma.naweo,.cT(andnni1ePo1ndozs9r0xaMowes17sirits-c9lkn--aeapoo)k-ir-.wnlPk1maid..0kuetiDaA8hoatuMsl.rne,ixpetuse.diptseVnrrGlevCaif..wbat.aih.sn(Pusli1:luttcAho9iaWzonarE6it.atneri2viiocmros)Iivnn..t.doa,aeeefNArcoanofdfen.2aci,luabrnd-.evamlredccno5rBfoehsd1ouG.hta.rshTroVuNyc4tslnrhaheil3yinc-ieuci9s4n.hrts--ireio4uloRcanoml4.bht.vors6ljpHo.goeL.ehlcyr.R.vfoetf(ese(2npe11.ms3cho99.Nt,7ele7s-7neCn3z1)uoot)e1o..xrfr8omNosyTa2felmae-ohtcct1zuugeheh1urnyetoe8nei.mcc9fg2cfh.Cs9eieeacpn,chcmartte1ilrodmi6aodch0lfu.ae0alnkrc--nPbeotedeairf1lcv.dft6hei2o0Adco.o4u4ertl.nss-.-. . GH"GHHHHKKNKHoaoiaulooiileemoleylflhmaudl.frd,hldssaccMabBdCr.,bsibgkoneA.oia.cEritJiacheGobeeoiinliencE...nlhtJsmrldileu.ttsisog.nd...,liEiWVd.n,meg.ocmare.,VCMesz.qphlrS.are,.uJKs.o.Noao,hu,Rncd...MHbcrMd-e.eKdhaEa.C.eRpJicia,nnDadnan.oo...h.uS.noGcnn,JddxCo(eetod(IileDo1dna.1RinnorLnrzs9nnnebaCV.9ilodiE.ei7t1tse,.maeo7sx.a(.zge7Ab9soaJo1l3r.yagRarm).HRe4..u9ln)kb.nnii.r.RJ.7easAn"PesayTids.,.nvn44l.Sdcg.t.eea.Ae..)di3(aAe.,pe.(..tn.O1inu5r1tranoSnTA.i9dTGcaTd9--nn,ccsHl,oa7hcroy7gcohda.irx9b.h.Aa1.1xcuGnerneai)4eclyi)hncptBSI.cd.(oc.3uriinot1l..cdtoa.raorWo(paBsS9tlioo1mM.lmH.x.nr,th4.pd9rawiJeidy7RnPboyue2a7c.ie2Ang)bgda,ntesi8h.d.9m-t..M.Betct..z)y4ua(eh.nuaoSTJ2.or74nKd2.Azn.lv)"mcot,od5a(2,looJdEiid1f(xi-r,aec.1-r1n8914i.DliTppnh3ctb92ec.775c9ee-o2oc.hai5ce-41o-d8m6tte71lduF9otny)9(nyi6r.a.1)y8e-mzo.po5dSc.,t0nro.xeo.dAh.3uVsoa)5.fPir7cfi.lctcu(n.ba3aoei0h1t2irs(tgsi12r-re.9ar1au1o.ioi53n.etd7pnn90r4nyLr8l0o9eeh8as,pe-6..s)sn.dt0eoati2.ei-.ni(r)isEfso151dc.aTnAe3n0n9AhtlNaohhrpa8--0vlcmncfeeoei0t9oahrh2err)Dn.lSeSoo5vm.u.ydcren5eiperciLPhsev.oc.vhyeedcorehapeecHoaxoisn.ysalnasnocnigsoetn4oecrhi.d-adtsex.tayhu"lcnMhetiytciscoerhgoaecaa2metrmecdinifvsndPdowte.tped.eheneteooeirCnarRrceifvruszntsehbde.:enpa2xalah.lDnrdeiI.opmcacd4toWcsiicoshbs.sdtpr5is.maeaitianoul-lynrs.ilt3faafr:igtrdo6Etaeeli6pnurRcm.ri1ors.rhntsee2u.eoelslw1yll2xob,11aa1&ca11iprjtt,e9.rehoni2e--ekx9oclpd8rW--out2nteih9esm4rnssce.n2i--ih0tglhnn0etekA.i3ea3noprivac0m.ntxtonet8ooasaynidd.l.ff
13634;
NCV AND exposure to phenoxy herbicide
311
NPaozrds3ftteeor7rnoro5mtmvs-3ua. o-7lAaVf8t.i.ic.ojlhnRulspoakrpoiopnfvea2.at.e,4CdJ-.d.,,dicLiNbhienleondmrzhocoapo-lhp.ve-aRdn..io.oMxxay.in,ndasPcBieactunkiscdoevrada.ci,ibHdJe-.naR, zn.Jodi(fr1ue29sr.7ae49nk.5)s..-.tLArSi.ncc, haaallnnyoddsr.iosLpJoh.ufekWnsaoosom.xrykEe .aEoc(ln1dev9teii8rrc1oS)an.cc.aTidnHhdefeioandrlatevhcvioaen5nl. PPoollaarnoanondpdnd.m..AAetHhn..e,etPaaam.ln,ntdhoSdlmepK3cir6etuo,hnlg.a5dnrD-eo1,ps.,1riAsoM..boee(f1.tct9eFh7rre6.od)Gn.. i.2Pc..r3aionn,7ctdo,.8xP3-ioT5csa,estt2iircoa4knc0,h4bPl-oy.2r(to41ed19t1ri7ba.1ce)hn. lzAoor-hoped-aidbliteohnxsziunor:-vpEe-ydnivooifxrowinnomirnkeemnrtseanlin.cAoarn2ct,ah4m.-DEinnaavnnidt RProessec2wno.fi4ttat.hl5.k-aL.Tl.kPpa.Fll.(ai.1nn9ePt7.ad5Ari)kur.,cr"JehE.s.,ilseEa.cnnBtdvrroiDrimto.anyJr.ro.iHgeCnrela.aipnIlh..thy(P1--2h92a7S.r9em)3n.1asT6coro-re3yla.2tam77n,.edn1Mt11oo-ft1os1er6vC.eorend2u.4c-tDionanFdinmdeincgosprionpNinortomxailcaStiuobn SSaeupepj(Drea2hlce,ao4ntit-smnfD..e"a)nMrT.kfo..eA.lclB.oh.wrnaLiiucninangld. osWrtreraOp.l,omBardt.l.amKuLi..na.Wbisaotn.rr,daaattinoModrnyaGntooeehflimrCnin.alingTn.,i.cPTa(.o1l(9x1N8i9c0e7o)u7.lor)No.gpTyehuh8yre,osifp3oah-tleyo1sgo1iyo.f,l2o.Rg4ii-gcdsaihcl hoaslnopdriotapplsheyte.cnhoCoxolyopagecincthiacalgapecinicd, SSeeppppetnaauxellraapreviionneoseeufncnros.,eonAAltdvo..ueMMcantti..mo..pniHHoxivutesuoesmrmlneobiacneonigrftg.i.eo,KAsrS.gm...aN.enaerainu.cndrJdso.MotKoIlvnaxoerdictcn.ekotnM.sls.oBoegSn.dyc..(a1C1n19(,.d72.(39)1,)1J.93.-7R418W23e)..l-oa3rNt3kioe2Eun. rsnohvpiiprhoybnse.iotHwloeegaeinlctahbl l4eo,fof3de0clt4es-a3od1fl4leo.vnegls-tearnmd STTVUTuhaoa.sSkoldkcem.dNnmAMHii2tuuni.ea1Ecn.piokdeust.RhnurrSrad.,rie2io.evsolic..RPcd7..it(h2r.ioY1.5JonaW1(x9r.-Rue.n.1.e2.6i.emm9c.g2a91Os8iin)(9tb7tes01.ny7dne.t)9Vo8rA.rt5ao.La.giTt3rfl,iicYg)lhona.iEiPen.sn-s,"r.pdeipoRaHesoRet.s.neefi.)rtsDtcpui.(a"appt1doeEninhe9oyrpeasex8tnat.gsr0poiraac/)tefAilo.i.m-rd2nnhgiPNee-meee4sCn.nrxy-.eptvlDcacinroKyonnhotuiifeaoidcns(t.lmEao1utolsaa9hcneynnx7t.avtssdd8irniJcti)red.ca.cnoC,mto-ntilaERheinomnnanecetndiaspehvbc.intniuaanJSartlitio.anuqttnaaNnleguIglromieHgeuiwspnue2erertaar.nia4eton.thfls,aMtot5eYeuohlr-nmxe..TrStvdiao(.pUcui.1txrto.r9FnioiSvloc8Binoeoven0drmgscye)iu.y..trase.bs"g.An5Ri"Jsatt2Wt.eyaica.MngloInios.6nlrmcotl6fedien34asp.Crss3me-ea.Mai(agrns6I7nraince68ctst&oi4dti)hn(rv,..P.anCeWtE.a31ihtso7nS7iietl.n1vpukmC1ieid2r6niao4noyc--ns1lcnal.doeel-.1B2ngr7CRce4a1aoteol57nhtons.7id.e,.f. Wallis, W. E-, Van Poznak. A., and Plum, F. (1970). Generalized muscle stiffness, fasciculations, and WYoauynuaO.m1gns9Jcye,d.7cdo8AMuk.Hap.y.uauLm(xtm1i.iio.9naan6Gno9ahalf)eR.lrpcaTbianesiogrkdcixnipdiioEhc.efneiJstrv..yHaiRAlraeoenrn.nb.sdemiiTrdchvehiuaednaezetloaakRrrlOeidegnHvrsi,a.netnCo.a2glA.6emth.rEaca3.nhL,n7..dea-dtb6Noio2aetmsrt.u.aretA(oos1tlrs9i.ysc7o,28ac2)Bni..airm"t4oeT3oad0khlss-eD,4aA3Tion9oixdr.xiinFwc.ooi"lrldcolOegifyEeB,HfarELsonem.vTiTsrRooe-mnx7m8aes-e9c.n2oOt.maclUmtFoSobaAnetelrFy,.
THEODOR D. STERLING, Ph.D.
I . Qualifications Dr. Sterling is a Professor in the Faculty of Interdisc ip lin ar y
Studies and Department of Co mputing Science, Simon Fraser University, Vancouver, British Columbia, Canada. His C u rr i c u lu m Vitae is attached. Dr. Sterling is pr esently on sabbatical; he teaches when active in that regard; Computation; Computers and Public Policy; Statistics; and various advanced topics.
II. Subject Matter Dr. Sterling is a mat he mat ic ian , statistician, and
epi dem iologist; as well, Dr. Sterling is intimately familiar with existing data and analyses concerning the effects of phenoxy herbicides and impurities, e.g., 2,3,7,8-TCDD , contained therein. Dr. Sterling has devoted much of his teaching and research to the c o l l e c t i o n and analysis of data and their use for scientific inference.
III. Scientific Principles See General Statement of Scientific Principles and Assumed Facts
attached.
IV. Substance of Opinions
V. Grounds for Each Opinion
A. Dr. Sterling will testi1.fy Report of the National Academy of
Sciences Committee on 2,4,5-T,
that there exists a considerable body of
to the Administrator of the Envir
onmental Protection Agency, May 7,
medical and scientific evidence which
1971 (of which Dr. Sterling was
a member).
demonstrates that the preparations
2. Summary of Evidence presented
of 2,4,5-T and 2,4,-D are toxic, terato
to The Royal Commission Hearings
on Herbicides and Pesticides,
genic and carcinogenic. That part of Dr.
July 16, 1974.
Sterling's testimony is based on the reviews 3. Hearings of the Assembly Committee
on Natural Resources of the State
of the literature and critical evaluation
of Wisconsin, March 19, 1975.
of data pertaining to the health effects of 2,4,5-T and 2,4-D on animals and humans
4. Hearings: Emergency Suspension Order for 2,4,5-T and Silvex, FIFRA, Docket 409-410, April 23, 1979.
and is contained in documents of which Dr. Sterling is the sole or contributing
5. Submissions to Environmental Appeal Board of British Columbia, Canada, May 18 and July 20, 1982.
author.
6. Evaluation of Data Submitted by Vietnamese Investigators in Inter national Group of Experts.
7. Sterling, T. and Arundel, A., The Epidemiology of 2,4,5-T (from 1969 to the present)., Journal of Northwest Coalition for Alternative to Pesticides, (in print), April, 1984.
B. Further, there is no credible scientific evidence of a no effect level; said another way, as a carcinogen, there is no safe
1. This is based on Dr. Sterling's analysis of data in Kociba, R.J., et al., Toxicology and Applied Pharmacology, 35, 553-574, 1976, and Rose, J.Q., et al., Toxicology and Applied Pharmacology, 36, 209-226, 1976.
level and therefore a single exposure years ago may be respon
2. IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemical to Humans
sible for human cancer which develops today.
3. Nicholson, William J., 1976. Occupational Carcinogenesis. New York Academy of Sciences. 271: 152-169
C. In addition, Dr. Sterling will testify that there is ample evidence that exposure to
1. Tofilan, P.J., Piper, W.N. 1982 2,3,7,8-TCDD. Mediated Depression of Rat Testicular Heme Synthesis and Micromal Cytochrome P. 450 Biochem. Parmacol. 31: 3663-3666
2,4,5-T is teratogenic in humans when the mother is exposed, and convincing evidence is not extant that the out come of pregnancy is influenced by expo
2. Constable, J., Hatch, M., Herbicide Exposure and Reproductive Outcome. In: Herbicides in War: The Long Term Effects for Man and Nature, A .W . Westing, ed. New York: Taylor and Francis, 1984 (in press)
sure of the father alone.
1. Besides review documen1.ts Nguyen Thi, et al., International
Symposium on Herbicides and De
listed above, additional evidence on
foliants in War, Ho Chi Minh City,
January 13-20, 1983.
teratogenic properties of 2,4,5-T for
2. Nguyen Can, et al., International
exposed mothers comes from two recent
Symposium on Herbicides and De
foliants in War, Ho Chi Minh City,
studies from Vietnam and one from
January 13-20, 1983.
Italy:
3. Bisanti, L., et al., Malformation
13638Registry, Department of Seveso,
Italv, June 28, 1982.
2. Evidence of birth de fects of children of fathers exposed to 2,4,5-T comes from:
1. Ton Due Lant, et al. , Interna tional Symposium on Herbicides and Defoliants in War, Ho Chi Minh City, January 13-20, 1983.
Hguyen Can, et al., Internation; Symposium on Herbicides and Defoliants in War, Ho Chi Minh City, January 13-20, 1983.
Report to the Ministers for Veterans Affairs: Case-Control Study of Congenital Anomalies an Australian Publishing Service, Canberra, January, 1983.
IV. D. and V. D. Most especially, Dr. Sterling will testify of the incidence of subjective symptoms and/or medical records documenting such symptoms. These symptoms are those which have been compiled by the National Center For Health Statistics, and will be compared, to the extent available, to those symptoms of the Vietnam veterans, particularly those of the reprsentatif plaintiffs. The purpose will be to ascertain the incidence of such symptoms in the general population so as to analyze statitically the symptoms of the plaintiffs. The product of such overall incidence will be calculated to examine the possibility or likelihood of such a constellation of Agent Orange/ dioxin related symptom complex to occur in a random fashion. Statistical analysis is based on data provided by Health Interview Survey of the National Center for Health Statistics. Tapes for the years 1969 through 1975 have been obtained by Dr. Sterling from the National Center for Health Statistics. The Health Interview Survey is a probability sample of the U. S. population consisting of ongoing
interviews of approximately AO,000 families per year. (so that Dr. Sterling's analyses is based on interviews of approximately 240,000 U.S. families). Dr. Sterling's projection of the probability of various symptoms in the U. S. population is based on the analysis of the HIS Data for the frequency with which these certain symptoms have been observed, singly or in combination. The symptoms include: lraphomas, soft tissue sarcomas, malignancy, various skin rashes, chloracne, eye light sensitivity, orthopedic impairment, especially of joint and of multiple sites, certain nervous symptoms memory lapse or temporary loss of memory, headache (but not migraine), depression, insomnia and tremors.
Besides the review of data listed here, the bases or grounds for the facts and opinions of Dr. Sterling's testimony are: educational and professional background; publications regarding the subject p'nenoxy herbicides; review of the applicable nedical and scientific literature; attendance and participation in various symposia dealing with the scientific issues in question; training as a mathematician, statistician, and epidemiologist; and training and experience in the computer sciences.
FURTHER REFERENCES. 1. TCDD is toxic, teratogenic and carcinogenic:
That part of Dr. Sterling's testimony is based on reviews of the literature and critical evaluation of data pertaining to the health effects of 2,4,5-T and 2,4-D on animals and humans and is contained in documents of which Dr. Sterling the sole or contributing author: 1. Report of the (National Academy of Sciences) Committee on 2,4,5-T
to the Administrator of the Environmental Protection Agency, May 7, 1971 (of which Dr. Sterling was a member).
2. Summary of Evidence presented to The Royal Commission Hearings on Herbicides and Pesticides, July 16, 1974.
3. Hearings of the Assembly Committee on Natural Resources of the State of Wisconsin, March 19, 1975.
4. Hearings: Emergency Suspension Orders for 2,4,5-T and Sylvex, FIFRA Dockets 409 and 410, April 23, 1979.
5. Submissions to Environmental Appeal Board in British Columbia, Canada, May 18 and July 20, 1982.
6. Evaluation of data submitted by Vietnamese investigators to international group of experts.
7. Sterling, T., and Arundel, A., The Epidemiology of 2,4,5-T (From 1969.to the Present), Journal of the Northwest Coalition for Alternatives to Pesticides, in print, April, 1984.
2. There is no known safe level nor is there "no effect" level:
This is based on Dr. Sterling's analysis of data in Kociba, R.J., et al, Toxicology and Applied Pharmacology, 35, 553-574, 1976, and Rose, J. Q., et al, Toxicology and Applied Pharmacology, 36, 209226, 1976.
3. TCDD is teratogenic:
Besides review documents listed above, additional evidence on teratogenic property of 2,4,5-T for exposed mothers comes from two recent studies from Vietnam and one from Italy: 1. Nguyen Thi, et al, International Symposium on Herbicides and
Defoliants in War, Ho Chi Minh City, January 13-20, 1983.
2. Nguyen Can, et al. International Symposium on Herbicides and Defoliants in War, Ho Chi Minh City, January 13-20, 1983.
3. Bisanti, L., et al. Malformation Registry, Department of Seveso, Italy, June.28, 1983.
Evidence of birth defects of children of fathers exposed to 2,4,5-T comes from: 1. Ton Due Lang, et al, International Symposium on Herbicides
and Defoliants in War, Ho Chi Minh City, January 13-20, 1983
2. Nguyen Can, et al, International Symposium on Herbicides and Defoliants in War, Ho Chi Minh City, January 13-20, 1983
3. Report to the Minister for Veteran's Affairs: Case-control study of congenital anomalies and Vietnam Service (Birth Defects Study), Australian Publishing Service, Canberra, January, 1983.
4. Further sut^orf for the "constellation" or ymptoms:
Statistical analysis is based on data provided by the Health Interview Survey of the National Center for Health Statistics. Tapes for the years 1969 to 1975 have been obtained by Dr. Sterling from the National Center for Health Statistics. The Health Interview Survey is a probability sample of the U.S. population consisting of ongoing interview of approximately 40,000 families per year. (So that Dr. Sterling's analysis Is based on interviews of approximately 240,000 U.S. families.) Dr. Sterling's projection of the probabilities of various symptoms in the U.S. population is based on the analysis of the HIS data for the frequency with which these certain symptoms have been observed, singly or in combination. The symptoms include: lymphomas, sarcomas, malignancies, various skin rashes, chloracne, eye light sensitivity, orthopedic impairment, especially of joints and of multiple sites, certain nervousness symptoms, memory lapse or temporary loss of memory, headaches (but not migraine), depression, insomnia and tremors.
ADGAEYNT
9
ORANGE MOYER
TRIAL V DOW
TESTIMONY 'XO
/
CO
f
p HM
UNITED STATES DISTRICT COURT EASTERN DI STRICT OF NE W YORK
In re
1 "Agent Orange"
li
1 Product Liability Litigation,
' A f i ,
' ,iY-
MDL No. 381 (All Cases)
M A G I S T R A T E 'S PRETRIAL ORDER
N o . 21
After receiving proposed voir dire questionnaires from plaintiffs and defendants, and hearing oral argument on ; those proposals, it is re sp ectfully re co mmended that the Court adopt the at tached voir dire questionnaire.
i D ated
^
i./8hir a A . Sche ind lin United States Magistrate
Brooklyn, New York April 6, 1984
//L
'I t"
P-049 il
r P f - M 4 9 -----( 0 - 8 0 - 2 5 0 M - 3 5 6 3
I
INSTRUCTIONS TO VOIR DIRE QUESTIONNAIRE
The attached questionnaire is to be filled out by you
| in order to assist the Court and counsel in the important.
!!j task of selecting a jury in the trial of a lawsuit jjijI concerning "Agent Orange," a product that was used during
ji the Vietnam War. You are to answer all of the questions to
j: the best of your ability, without help from any other
!! person.
We are requesting this information from you only to the
limited extent necessary to select a fair and impartial jury
ij in this litigation.
. .Only the Court and counsel in this
||i litigation will know your identity. After the questionnaire
;'ij has been reviewed, you will be called back to Court for
jiji| further questioning. The issues in this case will be fully explained to you
Ij by the Court at a latter date. The case will involve a good
! deal of scientific, medical and statistical testimony. You
; need not be expert in any of these fields in order to serve
i on this jury.
Jj The Court and counsel are aware that every person has
|ii certain beliefs and prejudices concerning many things.
Nonetheless you should answer the questionnaire with your
13647
P-Q49
y P I - M A R ------1. 3 0 - 8 0 - Z 5 M - 3 5 6 3
true feelings, whatever those may be. Do not assume that
any of your answers will qualify you or disqualify you from
iji serving on this jury.
The test for being a juror is whether
jj! or not you can hear the that determination will
j!
;i during jury selection.
evidence fairly and impartially and be made by the Court and counsel
Please fully answer each question to the best of your
j ability. Take as much time as you need to answer each
jj! question. The Court has approved the use of this
questionnaire and requests your full cooperation.
i
!: i|
13648
I . QUESTIONS ABOUT YOU AND YOUR FAMILY
1. Your sex ( ) male ( ) female
2. Year of birth :
3. M arital status ( ) single ( ) married or permanent companion ( ) divorced or separated ( ) widow
4. Schools (la st school) ( ) grade school ( ) high school graduate ( ) some c o lle g e ( ) college graduate ( ) trade school ( ) graduate school
5. Do you h ave a d e g r e e in ( ) science or engineering ( ) business ( ) law-related field ( ) health-related field ( ) other
6. Have you ever taken any courses in chem istry? ( ) yes ( ) no
i.
7. Do you have any c h ild r e n ?
If yes: lis t ages for
females: , , , ,
m ales:
,,,,
8. What i s the cu rren t y e a r ly income o f your household? ( ) Up t o $ 1 5 , 0 0 0 ( )$15,001 - $24,000 ( )$24,001 - $39,000 ( )$39,001 or more.
9 . What i s y o u r p r e s e n t o c c u p a t i o n ? : _________________________
1 0 . Name o f e m p l o y e r : _______________________________ _
11. L ist your prior occupations:
12. What i s th e o c c u p a tio n o f your spouse?
13. L ist the occupations of a ll your children. C h i l d #1 _________________________________________ C h i l d #2 _________________________________________ C h i l d #3 _________________________________________ C h i l d #4 _________________________________________ C h i l d #5 __________________________________________ Others
14. Have you ever worked for any agency of the Federal government in any capacity other than m ilita ry service? No ( ) I f y e s , w h a t a g e n c y ______________________________________________
-2- 13850
15. Have you ever worked for an insurance company? ( ) no ( ) yes If yes:
In what capacity?
16. Have you ever done any claim s adjustm ent work for any employer?
( ) yes ( ) no
17. If you are not employed o u tsid e the home, are you:
( ) a homemaker
I f so, how long?
( )a student
I f so, how long?
( )retired
I f so, how long?
( )disabled
I f so, how long?
( )seeking work
I f s o , how lo n g ?
( )other (specify)
18. What are your hobbies?
1 9 . How many y e a r s have you l i v e d a t you r p r e s e n t a d d r e s s ? _
20. Do you r e n t or own your home? ( ) rent ( ) own
21. Is anybody in your family -- a medical doctor? ( ) yes ( ) no -- in law enforcement? ( ) yes
` ' no
- 3-
1 3 651
t
-- a nurse or other health attendant? ( ) yes ( ) no
-- a lawyer or employee of a law firm? ( ) yes ( ) no
22. Have you or your spouse or companion ever receiv ed veterans d is a b ility compensation payments from the government? ( ) n o t t o my k n o w l e d g e ( ) yes, for partial d isab ility ( ) yes, for total d isab ility
23. Have you or your spouse or companion ever been denied veterans d isa b ility compensation payments, to your knowledge? ( ) yes ( ) no
24. Have any of your ch ild ren or th e ir spouses or companions ever received veterans d isa b ility compensation payments from the government? ( ) n o t t o my k n o w l e d g e ( ) yes, for partial d isab ility ( ) yes, for total d isab ility
25. Have any of your ch ild ren or th e ir spouses or companions ever been denied veterans d isa b ility compensatiion payments, to your knowledge? ( ) yes ( ) no
-4- 13652
I I . QUESTIONS ABOUT SERVICE IN THE ARMED FORCES
1. Have you ever served in the armed forces? ( ) yes ( ) no
If yes : a) In what branch ( ) Army ( ) Navy ( ) Air Force ( ) Marines ( ) Coast Guard ( ) N ational Guard ( ) Reservist ( ) Other b ) D u r i n g w h i c h y e a r s : 19 __ t o 19 __ c ) What was y o u r r a n k _____________________________ d) Did you serve in: ( ) W orld War I I ( ) Korea ( ) Vietnam e) Have you su ffered any i l l e ffe c ts from your m ilitary service? ( ) yes ( ) no f) If yes, what i l l effects?
2 Did any fam ily members, clo se frien d s, or r e la tiv e s ever
serve in the armed forces? ( ) yes ( ) no
If yes: a ) Did anyof them ever serve in ( ) W orld War I I ( ) Korea ( )V i e t n a m
-5-
b)
I f yes: a)
D id any o f them s u ffe r any i l l e f f e c t s from t h e ir m ilit a r y s ervice?
( ) yes ( ) no
What i l l e f f e c t s were s u ffe re d ?
b) P lease sta te that person's rela tio n sh ip t o y o u ______________________________________________
3. Have you, or your spouse or companion, or a r e la t iv e , or close friend ever been in a Veterans Hospital?
( ) yes ( ) no If yes: Please state that person's relationship to y o u ________________________________________________________
4. Have you, your spouse or companion or another member of your fam ily ever been a member o f one of th e fo llo w in g veterans organizations?.. ( ) yes ( ) no If yes, check which ones: ( ) American Legion ( ) V eterans of F oreign Wars
( ) Amvets ( ) D isabled American Veterans ( ) Vietnam Veterans of America ( ) Other ( f i l l i n ):
5. Has a n y o n e c l o s e t o y o u b e e n k i l l e d o r s e r i o u s l y
in ju re d , or s u ffe re d a serious disease du rin g m ilit a r y
s e rv ic e ?
( ) yes ( ) no
13654
-6-
If yes: Where?
( )K illed ( )Seriously injured ( )Serious disease
( )Vietnam ( )Korea ( ) W orld War I I ( )Other ( f i l l i n ) :
6. Do you b e l i e v e t h a t t h e governm ent b e n e f i t s made availab le to Vietnam veterans are: ( ) too low ( ) too high ( ) about right ( ) don 11 know
I I I . QUESTIONS ABOUT CONTACT WITH CHEMICALS
1. Have you, your spouse or companion, ever had a job working in contact with chem icals? ( ) yes ( ) no If yes: a) Has any o f them s u ffe r e d any i l l e ffe c ts from these chem icals? ( ) yes ( ) no If yes: What i l l e f f e c t s ?
2 . Do you h a v e any c l o s e f r i e n d s o r r e l a t i v e s who h a v e e v e r had a job working in contact with chem icals? ( ) yes
( > no
13655
-7-
If yes: a) Has any of them su ffe r e d any i l l e f f e c t s
from th ese chem icals, to your knowledge? ( ) yes ( ) no
I f y e s: What i l l e f f e c t s ?
3. Have you, your spouse or companion, or one of your children, r e la tiv e s or clo se friends ever worked for any chem ical company? ( ) yes ( ) no If yes, which one?
4. Have you had any personal exp erien ce with p e s tic id e s or other chem icals in the course of farming, gardening, tending the lawns or some lik e a c tiv ity ? ( ) none ( ) a little ( )some ( )quite a lot
5. To your know ledge, have you or any member o f your fa m ily ever purchased or used any chem ical manufactured by the defendant chem ical companies lis t e d on the next page? ( )yes ( )no
-8-
If yes, please check those companies whose chem icals you have purchased or used.
( ) Dow ( ) Monsanto ( )Hercules ( ) T-H A g r ic u ltu r e ( ) Diamond Shamrock ( )Uniroyal ( )Thompson Chemical
6. Have you or any member of your fam ily ever owned or worked for a company which manufactures or s e lls h erb icid es (plant and weed k ille r s )? ( )yes ( ) no I f y e s , p le a s e name th a t company:
7. Do you b e l i e v e you have e v e r been e x p o se d t o A gent Orange, a h erb icid e sprayed by the American m ilita ry in Vietnam?
( ) yes ( ) no
8. Do you know anyone who b e l i e v e s he or she has e v e r been
exposed to Agent Orange?
( ) yes
( ) no If yes, is he or she a:
( ) spouse or companion? ( ) child?
( ) close relative? ( ) close friend? ( ) acquaintance?
9. Have y o u a n y v i e w s a b o u t t h e u s e o f A g e n t O r a n g e ?
( ) yes ( ) no
13Ot 0 0 3
-9-
.0 1
If yes, what are those views?
1 0 . Do any o f you r c l o s e f r i e n d s or f a m ily have any v ie w s concerning the use of Agent Orange?
( ) yes ( ) no If yes, what are those views?
11. If you have answered yes to the previous question, w ill the views of those friends and/or rela tiv es a ffect your views about the use of Agent Orange? ( )yes ( )no
12. W ill your views or those of fam ily or friends a ffect your a b ility to be fa ir and im partial in deciding the issu es in th is case? ( )yes ( )no
I V . QUESTIONS ABOUT CHEMICAL CORPORATIONS AND BIG CORPORATIONS IN1* GENERAL
1 . How do y o u f e e l g e n e r a l l y a b o u t b i g c o r p o r a t i o n s ? ( ) I lik e them ( ) I do not lik e them ( ) I have no strong fe e lin g s one way or the other
-10- 1365S
<c
2. How do you f e e l a b o u t c o r p o r a t i o n s in t h e c h e m ic a l industry? ( ) I lik e them ( ) I do not lik e them ( ) I have no strong fe e lin g s one way or th e oth er
3. Would your fe e lin g s about b ig corp oration s a f f e c t your a b i l i t y to be f a ir and im p a r tia l in d e c id in g th e is s u e s in. this case? ( ) yes ( ) no
4. Do you own any s t o c k s , bonds or o t h e r s e c u r i t i e s ? ( ) yes ( ) no
If yes: ( ) I own j u s t a few . ( ) I own many. ( ) I own some but would say I f a ll somewhere in between the f ir s t two answers.
5. Are you a shareholder or stockholder in any chem ical companies? ( ) yes ( ) no
6. Are you a shareholder or stockholder in an insurance company? ( ) yes ( ) no
7 . Do you own s t o c k in or have you worked f o r any company which to your knowledge does business with the United States government? ( ) yes ( ) no
-11-
fs
8. Does any member o f your fa m ily own sto c k in , or been employed by, any company which to your knowledge does business with the United States government?
V. QUESTIONS ABOUT YOUR HEALTH
1. Would you say your h ea lth (co n sid erin g your age, e t c .) is ) excellent ) o.k. ) not too good
2. If you have experienced any of the illn e s s e s or symptoms on t h e a t t a c h e d l i s t p l e a s e p l a c e an "X" t h r o u g h t h a t illness :
Cloracne; porphyria cutanea tarda; hyperpigmentation; hyperkeratosis; hirsutism ; asthenia; weakness in lower extrem ities; loss of strength; easy fatigab ility; fatigue; headaches; peripheral neuropathy; polyneuropathy; intolerance to cold; other neurological d e fic its ; ir r ita tio n to eyes; impairment of sigh t; impairment of hearing; impairment of sm ell; impairment of taste; loss of weight; loss of appetite; anorexia; loss of sexual drive; sleep disturbances; orthostatic hypotension; abdominal pain; nausea; vom iting; diarrhea; other gastroin testin al disorders; neurasthenia; depression; violen t behavior; other psychobehavioral disorders; myocardial infarction; ath erosclerosis; other cardiovascular disorders; liv e r damage; pancreatic dysfunction; kidney disorders; urinary tract disorders;
-12-
pulmonary p ath ologies; other respiratory disorders; fat metabolism disorders; carbohydrate metabolism disorders; cholangiocarcinom a; other liv er cancers; kidney cancer; bladder cancer; pancreatic cancer; colon cancer; stomach cancer; other gastro in testin a l cancers; lung cancer; fibrosarcoma; leiomyosarcoma; liposarcoma; rhabomyosarcoma; myofibrosarcoma; neurofibrosarcoma;
fibrous histiocytom a; retroperitoneal neurogenic sarcoma; fiberosarcomatous mesothelioma; other so ft-tissu e sarcomas; leukemia; angiosarcoma; other blood cancers;
hepatoma; lymphoma; squamous c e l l carcinoma of skin; other skin cancers; thyroid cancer; other glandular cancers; cancer of tongue; cancer of hard palate; other cancers of mouth; chronic lym phocytic leukem ia, various brain cancers; ischem ic heart disease; lung fib ro sis; lo ss of body weight; lo ss of lymphoid tissu e ; lo ss of thymus t is s u e ; s e n s i t i v i t y to in f e c t io n s ; immune system disturbances; brain cancer; m ultiple sclero sis; t e s t i c u l a r c a n c e r ; DNA d i s t u r b a n c e s ; RNA d i s t u r b a n c e s ; skin eruptions and cy sts; slow ing of nerve im pulses; hypertension; elevated blood lip id lev els; elevated ch o lestero l le v e ls; prediabetic and d ia b etic sta te s; abnormal c e ll p ro lifera tio n s; organ enlargem ents; cellu lar atrophy; decreased c e ll proliferation ; birth
defects in offspring; m iscarriages; increased white blood c e l l c o u n ts; e l e v a t i o n o f e o s in o p h il; d e c r e a se in IgM and IgD; decrease in B -c e ll and T -c e ll c a p a b ilitie s ; skin rash; scalp tumors; aching muscles; blepharo co n ju n ctiv itis; porphyria; untoward pregnancy outcomes, including birth defects or malformations, m iscarriages, sponaneous ab ortions, and s t illb ir t h s ; in to lera n ce to alcohol; in sen sitiv ity to ligh t, i.e . photosensitivity; muscle spasm; jo in t pain; muscle pain; ear in fectio n s; b asal c e l l carcinom a; m alignant lymphoma; n ig h t sw eating;
memory lo s s ; r e c t a l b leed in g ; e p ile p t ic s e iz u r e s ; b lack -ou ts; other skin problems; m igraine headaches,-: blurred vision; autotonic neuropathy.
3. Do any o f th e c o n d i t i o n s w hich you ch eck ed o f f above prevent you from fu n ction in g normally in day to day l i f e now? ( ) yes ( ) no
4. If your spouse, companion, close r ela tiv e or clo se friend has experienced any of the illn e s s e s or symptoms on the a t t a c h e d l i s t , p l e a s e p l a c e an "X" t h r o u g h t h a t i l l n e s s :
Cloracne; porphyria cutanea tarda; hyperpigmentation; hyperkeratosis; hirsutism ; asthenia; weakness in lower extrem ities; loss of strength; easy fatigab ility; fatigue; headaches; peripheral neuropathy; polyneuropathy; intolerance to cold; other neurological d e fic its ; ir r ita tio n to eyes; impairment of sigh t; impairment of hearing; impairment of sm ell; impairment of taste; loss of weight; loss of appetite; anorexia; loss of sexual drive; sleep disturbances; orthostatic hypotension; abdominal pain; nausea; vom iting; diarrhea; other gastroin testin al disorders; neurasthenia; depression; violen t behavior; other psychobehavioral disorders; myocardial infarction; atherosclerosis; other cardiovascular d isord ers; liv e r damage; pancreatic dysfunction; kidney disorders; urinary tract disorders; pulmonary p ath ologies; other respiratory disorders; fat metabolism disorders; carbohydrate metabolism disorders; cholangiocarcinom a; other liv er cancers; kidney cancer; bladder cancer; pancreatic cancer; colon cancer; stomach cancer; other g a stro in testin a l cancers; lung cancer; fibrosarcoma; leiomyosarcoma; liposarcoma; rhabomyosarcoma; myofibrosarcoma; neurofibrosarcoma; fibrous histiocytom a; retroperitoneal neurogenic sarcoma; fiberosarcomatous mesothelioma; other so ft-tissu e
-14- 13662
sarcomas; leukemia; angiosarcoma; other blood cancers; hepatoma; lymphoma; squamous c e ll carcinoma of skin; other skin cancers; thyroid cancer; other glandular cancers; cancer of tongue; cancer of hard palate; other cancers of mouth; chronic lym phocytic leukem ia, various brain cancers; ischem ic heart disease; lung fib ro sis; loss of body weight; lo ss of lymphoid tissu e; lo ss of thymus t is s u e ; s e n s i t i v i t y to in f e c t io n s ; immune system disturbances; brain cancer; m ultiple sclerosis; t e s t i c u l a r c a n c e r ; DNA d i s t u r b a n c e s ; RNA d i s t u r b a n c e s ; skin eruptions and cy sts; slowing of nerve im pulses; hypertension; elevated blood lip id lev els; elevated c h o lestero l le v e ls; p rediabetic and d iab etic sta te s; abnormal c e ll p ro lifera tio n s; organ enlargements; cellu lar atrophy; decreased c e ll p roliferation; birth defects in offspring; m iscarriages; increased white blood c e l l c o u n ts; e l e v a t i o n o f e o s in o p h il; d e c r e a se in IgM and IgD; decrease in B -c e ll and T -c e ll c a p a b ilitie s ; skin rash; scalp tumors; aching muscles; blepharo c o n ju n ctiv itis; porphyria; untoward pregnancy outcomes, including birth defects or malformations, m iscarriages, sponaneous abortions, and s t illb ir t h s ; in toleran ce to alcohol; in sen sitiv ity to light, i.e . photosensitivity; muscle spasm; jo in t pain; muscle pain; ear in fectio n s; basal c e l l carcinom a; m alignant lymphoma; n igh t sw eating; memory lo s s ; r e c t a l b leed in g; e p ile p t ic se iz u r e s; black-outs; other skin problems; migraine headaches; blurred vision; autotonic neuropathy.
5. Do any o f t h e c o n d i t i o n s w hich you c h e c k e d o f f above prevent your spouse, companion, clo se friend or close r e l a t i v e from fu n c tio n in g in day to day l i f e now? ( ) yes ( ) no
-15-
6. Are you se n s itiv e to chem icals? ( ) yes ( ) no ( ) I don' t know
7. Are you s e n s itiv e to dust and other things in the air? ( ) yes ( ) no ( ) I don't know
8. Do you h ave any a l l e r g i e s ? ( ) yes ( ) no
a) If y es, what symptoms do you suffer?
9. Do you smoke?
( ) no ( )somewhat
( )heavily
V I . QUESTIONS ABOUT THIS CASE
1. Many p e o p le are s y m p a t h e t ic t o p e o p le who h ave i n j u r i e s or
a r e d i s a b l e d . How im p o r t a n t w o u ld su ch sym p ath y b e t o t h e
way you would weigh the ev id en ce and d ecid e as a juror in
this case?
( )Extremely
( )Very
( )Somewhat
( )Not too
( ) Not at a ll
13664
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2. I f t h e J u d g e i n s t r u c t s y o u t h a t s y m p a t h y s h o u l d n o t a f f e c t your verd ict, could you follow such directions?
( ) yes ( ) no
3. Assume there are badly injured people in clu d in g ch ild ren who t e s t i f y in t h i s c a s e . I f th e e v id e n c e shows th a t th e y , p la in t if f s , are not e n title d to a recovery, would you be able to render a verdict against the p la in tiffs?
( ) yes ( ) no ( ) I don't know
4. If the evidence shows that defendants, chem ical companies,
are at fa u lt for p la in tiffs ' in ju r ie s, would you be able to render a verdict against defendants?
( ) yes ( ) no ( ) I don't know
5. P la in t if f s are making claim s for money damages in th is c a s e . Do you h ave any f e e l i n g s a b o u t p e o p l e m aking c la im s for money damages?
( ) yes ( ) no
6. P la in tiffs claim the defendants have caused them serious in ju r ie s. If you fin d in favor of the p la in t if f s , would you have any h e s ita tio n in awarding the p l a i n t i f f s money damages, even i f such sum o f money was v ery la r g e ?
( ) yes ( ) no
7. Do you r e a d any n ew sp a p e r s on a r e g u l a r b a s i s ?
( ) yes ( ) no
e ft
-17-
If yes, which newspapers?
8. Do you r e a d any m a g a z in e s on a r e g u l a r b a s i s ? ( ) yes ( ) no
If yes, which magazines?
9 . How o f t e n do y o u w a t c h TV ne ws and news d o c u m e n t a r i e s ? ( )never ( )rarely ( )fairly regularly ( )very frequently
1 0 . A b o u t how many n e w s p a p e r , TV o r r a d i o s t o r i e s h a v e y o u seen or heard that discussed Agent Orange? ( )none
( )one or two
( ) 3 to 10 ( ) more than 10
1 1 . Have y o u s e e n a m o v i e o r TV sh o w w i t h i n t h e p a s t tw o o r three years that reminds you of or is sim ilar to issues concerning the use of Agent Orange? ( )yes ( ) no I f y e s , w h i c h m o v i e s o r TV s h o w s ?
-18-
13666
12. Would anything you have read or seen concerning Agent Orange a ffe c t your a b ility to fa ir ly decide th is case? ( ) no ( ) yes (p lea se s t a t e how)
13. L ist a ll the organizations you have belonged to in the la st 20 years o f a c i v i c , p o l i t i c a l , s o c ia l or fr a te r n a l type:
V I I . QUESTIONS ABOUT YOUR EXPERIENCE WITH THE LAW
1. Have you ever been a juror before in a tr ia l? ( ) yes ( ) no
If yes: a) In a b o u t how many c r i m i n a l t r i a l s ? # ____ In a b o u t how many c i v i l t r i a l s ? #____ If you were a juror in a c i v i l t r ia l, what was the most recent one about?
Did the jury deliberate? ( ) yes ( ) no
-19-
136G7
If yes, did it reach a verdict?
( ) yes ( ) no If you were a juror in a c iv il tr ia l before the one ju st described, what was that earlier case about?
Did the jury deliberate?
( ) yes
( ) no If yes, did it reach a verdict?
( ) yes ( ) no b) If you were a juror in crim inal t r ia ls , what were they about?
Did the jury deliberate?
( ) yes
( ) no If yes, did it reach a verdict?
( ) yes
( ) no Have you or another member of your fam ily ever sued
somebody for money in a court?
( ) yes
If yes:
( ) no
a) What was i t about?
1 3 6 6 8- 2 0 -
b) H o w d i d t h e c a s e end?
c) Would th at outcome a f f e c t your a b i l i t y to be a fa ir and im partial juror in this case? ( )yes ( )no
3. Have you or another member of your fam ily ever been sued by somebody? ( )yes ( )no If yes: a) What about?
b) How d i d t h e c a s e or c a s e s end?
c) Would that outcome a f f e c t your a b ilit y to be a fa ir and im partial juror in this case? ( ) yes ( ) no
4. Have you or another member of your fam ily ever made a claim against someone for a personal injury, even though no law su it was brought? ( ) yes ( ) no If yes: a) What about?
-2 1 -
b) W h a t w a s th e o u t c o m e ?
c) Would th at outcome a ffe c t your a b ilit y to be a fa ir and im partial juror in this case? ( ) yes ( ) no
5. Have you ever been a w itness at tr ia l? ( ) yes ( ) no
If yes, please describe:
6. Do you f e e l t h a t you know a g r e a t d e a l ab ou t t h e law?
( ) no ( ) about some parts of i t
( ) yes
7. Would you f u lly d iscu ss the case with your fe llo w jurors during jury deliberation which occurs at the end of the case?
( )yes ( ) no
8. Would you be w illin g to change your mind i f you were convinced to do so as a r e su lt of d iscu ssio n s with your fellow jurors?
( )yes ( ) no
9. Would you be w i l l i n g to s t ic k w ith your view s i f you were
not convinced to change them after discussion with your
fellow jurors?
( )Yes
( ) no
13670
-2 2 -
* V 9r
1 0 . How i m p o r t a n t t o you a r e f a c t s when you d e c i d e s o m e t h i n g ? ( ) extremely ( ) very ( ) somewhat ( ) not too ( ) not at all
1 1 . How im p o r t a n t a r e h u n c h es when you d e c i d e so m e th in g ? ( ) extremely ( ) very ( ) somewhat ( ) not too ( ) not at all
1 2 . When so m e o n e i s s e r i o u s l y i n j u r e d , do y o u b e l i e v e he o r she should be compensated regardless of what the evidence shows? ( ) yes ( ) no
13. There are d ifferen ces of opinion concerning the amount of environmental regulation the government should in sist on. Would you say ( ) t h e r e are a lr e a d y to o many regulations ( ) the amount is about righ t ( ) there should be more ( ) no opinion
14. Have you heard oth ers in your fam ily or among your frien d s and acquaintances express an opinion as to the merits of this case?
-23- 13671
19. There w ill be testim ony in th is case on complex medical q u e s tio n s w ith many t e c h n ic a l words and terms you have probably never heard of. Their meaning w ill be explained t o you a t t r i a l . Do you f e e l t h i s would a f f e c t y o u r a b ility to be a juror in th is case? ( )yes ( ) no
2 0 . Do y o u , a co m p a n io n , anyone i n y o ur f a m i l y or any c l o s e friend have any feelin g s about chemical companies that would prevent you from hearing the evidence in th is case im p artially? ( )yes ( )no If yes, describe these feelings:
21. Do y o u , a c o m p a n io n , anyone i n y o u r f a m i l y o r any c l o s e f r i e n d h a v e any f e e l i n g s a b o u t t h e V i e t n a m War t h a t w o u l d prevent you from hearing the evidence in th is case im p artially? ( ) yes ( ) no If yes, describe these feelings:
22. Is there any personal, occupational, medical, emotional or other reason that you should not be sele c te d as a ju ror in the Agent Orange c a s e which may l a s t fo r several months? ( ) yes ( ) no
13673
-25-
If yes, please state: 23. Is there anything you would lik e to add to your
responses that might aid the court in selectin g a fair and im partial jury in th is case?
T HA N K YOU
- 2 6 - 13674
AGENT ORANGE JURY QUESTIONAIRE
1. What is your name? 2. What is your address? 3. What is your date of birth? 4. What is your occupation?
FILED
u. s. DINISTCRLIECRTK'CSOUORFFTICEE.D. N.Y. 1 /^ 4
5. Who is your employer?
6. For how long have you had your present job?
7. Please describe your prior job.
8. Education you have completed:
Grade School -
High School -
College -
Post graduate -
9. Family:
Spouse's name -
Spouse's occupation -
Childrens names, ages and occupations -
10. Do you or any members of your family belong to any organizations? If so, which ones.
11. Are you or any members of your family an officer, director or trustee in any of the above organizations? If so, please identify.
12. Have you ever been a juror before? If so, where, when and what kind of case?
13. Are you now or have you ever made a claim for personal injuries caused by accidents of any kind? If so, please describe giving the type of claim and if it is still pending.
14. Have any members of your family made claims for personal injuries caused by accident of any kind? If so, please describe giving the type of claim and if it is still pending.
15. Have you ever had a claim brought against you? If so, please describe giving the
type of claim and if it is still pending.
136,75
1 6 . Have any members of your family had a claim brought against them? If so, please
describe giving the type of claim and if it is still pending.
17. Are you now or have you ever been an officer, director, stockholder, shareholder or in any way interested in any insurance company insuring against claims for personal injury?
18. Are any members of your family now or have they ever been an officer, director, stockholder, shareholder or in any way interested in any insurance company insuring against claims for personal injury?
19. Have you or any members of your family ever testified in Court? If so, please describe the circumstances.
20. Do you have any hobbies? If so, please so state,
21. Have you ever taken any courses in chemistry?
22. Are you now or have you ever worked in any occupation involving chemistry or chemicals?
23. Have any members of your family, now or in the past, ever worked in any occupation involving chemistry or chemicals?
24. Are you now or have you ever worked for a chemical company? If so, please describe.
25. Have any members of your family, now or in the past, ever worked for a chemical company? If so, please describe.
26. Are you now or have you ever owned or worked for a company which did business with any chemical companies? If so, please describe.
27. Have any members of your family, now or in the past, ever owned or worked for a company which did business with any chemical company? If so, please describe.
28. Are you now or have you ever owned or worked for a company which manufactured or sole herbicides (plant killers)? If so, please describe.
29. Have any members of your family, now or in the past, ever owned or worked for a company which manufactured or sold herbicides (plant killers)? If so, please descrik
30. Have you or any members of your family ever used herbicides (plant killers)? If so, please describe the type of use and the product used.
31. To your knowledge, have you or any members of your family ever purchased or used any product or products manufactured by the defendant chemical companies? If so, please describe in detail.
32. To your knowledge, have you or any members of your family ever purchased or used any chemicals manufactured by the defendant chemical companies? If so, please describe in detail.
33. Have you or any members of your family ever lived or worked on a farm? If so, do you know whether herbicides (plant killers) were used?
34. Have you or any members of your family ever served in the armed forces? If so, please describe by name, years and place of service.
2
35. Do you now or have you ever owned any stocks and bonds?
36. Do you now or have you ever owned any stocks and bonds in chemical companies?
37. Do you now or have you ever owned any stocks and bonds in any companies doing business with chemical companies?
38. Do you now or have you ever owned or 'worked for a company which did business with the Government?
39. Have any members of your family, now or in the past, ever owned or worked for a company which did business with the Government?
40. If you were selected as a juror in the Agent Orange case, and if the trial lasted for several months, would you be able to be a juror?
Dated: April 2, 1984
Respectfully submitted,
PLAINTIFFS' MANAGEMENT COMMITTEE
DAVID J. DEAN, ESQ.
DEAN, FALANGA & ROSE, ESQS.
One Old Country Road Carle Place, New York
11514
(516) 248-9888
CERTIFICATE OF SERVICE
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13673
UNITED STATES DISTRICT COURT EASTERN DISTRICT OF NEW YORK
X
In re
"AGENT ORANGE
Product Liability Litigation
x
MDL 381 (All Cases)
PLAINTIFFS' SECOND AMENDED LIST OF FACT WITN ES SES IN SUPPORT OF CLAIMS
April 3, 1984
PLAINTIFFS' MANAGEMENT COMMITTEE Room 304 26 Court Street Brooklyn, NY 11242 (212) 330-0900
13680
PLAINTIFFS' SECOND AMENDED LIST OF FACT WITNESSES IN SUPPORT OF CLAIMS
P l a i n t i f f s submit the follow in g l i s t of p o te n tia l w itn e sse s to be ca lled at tr ia l pursuant to the M agistrate's P retria l Order No.
18, dated March 26, 1984, reserv in g the righ t to supplement th is l i s t with a d d itio n a l names and addresses from time to time as
a d d itio n a l inform ation and w itn e sse s are d isco v ered .
Those w i t n e s s e s d e s ig n a te d w ith an a s t e r i c k "*" have been deposed
in th ese p roceed in gs. Their addresses and the nature of relev a n t portions of their testimony are as equally well-known to the defendants as to the p la in tiffs.
The w itnesses not covered by the above reservation s, are, as follow s:
DTRo .l e dToHOMCAlSi n Ai cBOUD 4235 Secor Toledo, Ohio
C ardiologist for Mrs. Ford Treated Danny Ford for hypertension.
EDWARD E ADAMS S t . L o u i s , Mo.
G1O0 R2 DOHNi c kA.o r yANDLEaRnSe ON* Naugatuck, Connecticut IRENE ANTONIK 812 Sussex A u s t i n , TX 7 8 7 4 5
LOUIS B .A R N O L D I *
EUGENE BAK* D7 7O2N2ALDR eKv.e lBl eALLDMrAi vNe* La J o l l a , C a l i f o r n i a
Govt. W it n e s s , T-H Agriculture Texas D isab ility Officer and friend of Jordans'
13681
DONALD BARNES
E. D. BAUMGARTNER R. E. BAYNARD JFPEleAorwNs oNe rnIEn He BloEsADpVeiEpt RaaSlr t m e n t Sylvania, Ohio B4 4IL0 4LIEB oMn AnRi eIE DBrEi Lv Le F t . W o r t h , TX 7 6 1 1 6 CLOYCI G. BELL F4 4t0. 4 WBoornt hn,i e TXD r i v7e6 1 1 6 BELL TELEPHONE OF PA. 1P hPial rakd eWl payh i a , P a . 1 9 10 1 W. B. BELLS
A ttem p tin g to Locate
PETER S. BING* ETCYL H. BLAIR*
JOHN BLISH Attempting to Locate AAK.At tNeASmA. SpBtLCi nOIgCTKY,t o MLO.o c a t e WA ItLt eLmIApMt i nBgLUMt oENALUoEcRa t e JAOtSt Ee mPHp t iLn. g BOt oLTOLNo c a t e
J1A2C9K2 0 BWOReRlEl sRw*o o d T r a i l C h esterfield , Ohio 44026 AN6L1e0wBpOHoTruHtdWs oNEnLeLwTs ,e r Vr aac. e 2 3 6 0 5
2
EPA
Knows th e h o s p i t a l and business s tr a in re Danny Ford
Danny J o rd a n 's mother
Danny Jordan's StepFather Personnel records of George Ewalt
Dow Employee Deposed twice Contract Officer re Monsanto GT-oHv t .A gWr iict un el tsus r er e
G ov't Contracting O fficer P a rtic u la rly re; Hercules
High School friend of
L a m b io tte 's who was w ith
him in Vietnam
13882"
JSATM. ESLOEU.ISB, OWMEOR. S Attempting to Locate Dc10/Ao0NIEBEL.e l lABRrATmXeTltOe pNh o n e o f PA P h i l a d e l p h i a , PA. BOB BROWN
Attem pting to Locate
ABRtOt eWmNp, t iSnGgT. t o L o c a t e DAVE BUNIN
JOHN S. BUSH, J r . *
WWIeLsLt IAVMi r Cg Ai nLLi aAHAN Attempting to Locate MB2 6Ee8Lr3VkIeNBl euyCen,AaLCVVIaNil*si ft ao r nWiaay
CRIiCnHcAiRnDn aCtAi ,SEYOhio Attempting to Locate
ELLIS CASH Attempting to Locate EDWARD LEE CHANDLER* EDWARD E. CHAPMAN* 6748 N. E uclid Gladstone, Missouri J . G. CHARLTON R23OBECRaTr mLe.l l aCHDONr Oi vLeES* E d iso n , New J e r s e y EMIL CHRISTOFANO*
Govt. W itness re T-H A griculture
George Ewalt's Foreman, 1975
Served w ith Dan. Jordan in Vietnam W ith Danny Ford in sprayed areas Economist - W ill s u p p ly a d d res s and summary m a t e r i a l s
Was w i t h E w a l t i n V i e t n a m
Fanodrmderi r emcetmobrer o of f DPowSAC Chemical re government kk nn oo ww ll ee dd gg ee vans d. Df aoiwl'us r e to warn. Tv ieeswt i moof n y" Rfarnocmh hpaonidnetr "o f cs po nr ac ye ri nngi n gandf a dc tesf ool if a t i o n Govt. Contracting Officer re Hercules
1 3 6 8 3Re H e r c u l e s ' l i a b i l i t y
GEORGE F. COLLINS
JA.t t eGm. pCt iOnPgELAt oNDL, oJcra.t e DIANE COURTNEY* G49EORHGeEck &RMdA. RGE CRAWFIS Kennessaw, Ga. JOHN CRAWFIS A1 1t7l 9a n Bt ae,a c hG eVo ragl il ae y Rd . TO6 W1o-El8Ne3d o&W, BhEOiThtTeiYof o rCdRACWeFnISt e r Rd . ROBERT CROCKER Attempting to Locate
EUGENE D. CRITTENDEN, J r . *
ROBERT CROCKER Attempting to Locate WARREN CRUMMETT* M80i8d l aCnrde,s c Me nitc hDi grainv e AGEtNt eEmCpUt Mi nMgINGt oS L o c a t e BILL CURTIS c5/2o4 WCBeSs t Ne5w7st h S t r e e t New York, New York 10019
&
D ire c to r of procurement P ro d u c tio n , Richmond, Va. (P ro c u re m e n t, s u p p ly and f a i l u r e to warn issues)
GA esns .t . MGgre.n . SMy na nt ha ge et ri c, s ,' 6 4 65-72 (Re H e r c u le s) Government expert w itness on causation CSahwr icsh' sa n Bg erso t hi ne r Daanndny S Fi sotredr
in Law Chris' Brother
MUsoettdrheearttomanet dankt eda(d6D1a3on8fn?y)Cfhorri s . Amounts - doing away of herbs - has tapes to dt oe t eVremt ei nr ae n se x pI oI s' su r e AD isrs.t . SGa el en s. , M6g6r-. 6 7S y n t h e t i c s 67-68 W90i8l mDi un Pg ot onnt , RDoaedl . 1 9 8 0 7
Dow s c i e n t i s t ; e v i d e n c e ci so snuc eersn. i n g Dow l i a b i l i t y Served with Jordan in Vietnam Ee yvei dweint nc ee s sc o no cbesrenr ivnagt i o n s Voa sfi e tttnohaemt hc, eo ue xcnott ernnydti ot ifoofn pr eossisdi ub al el dp he of ot ol igar taipohni c and exhibits; investigation
13634
THOMAS P. DALBY
S. S. DANIELS L. L. DANIELSON Attempting to Locate EDWARD DEBOLT Attempting to Locate ADItAt eZm, pStTi nAgFF t oSGLT.o c a t e CHARLES DILLEY AKAt tNeSmASp t iCnIgTYt, o MLO.o c a t e NL42IeNsDGcAoi bnbDssIeMtOPt L,oAndNYRd1. 1 7 6 7 CHARLES DISHNER M DOJNY
OC5W2h2Ea5Nr lDSeuOsntLoINnV*,a lWl eeys t DVr iivr eg i n a LAWRENCE E. DOTSON* WILLIAM DUFFIELD CHARLES L. DUNN*
J9O6 SEHPaHl l oDcUkQUSETaTnEd i n g R d . R o c k e y P o i n t , NY 1 1 7 7 8 J . M. EAGAN* J8A0C2K4 DL.a kEeAnRhLeYa*t h Way Potomac, Maryland 20854 WAYNE EDWARD*
continues
Govt. Contracting Officer re Hercules U . S . D . A . L i a s o n NACA
With Ewalt in Vietnam Govt. Contracting Officer re T-H A g r ic u ltu r e Kerry Ryan's Babysitter
Govt. Contract Officer re Uniroyal
C h a ir m a n , NACA; e v i d e n c e ar ef f el ci at ibnigl i tmyanyi s sdueef es n d a n t s in addition to Hercules. On S u f f o l k C o u n t y P o l i c e Force with Mike Ryan
13685
5
PLATOON SGT. ELLY Attempting to Locate
Was w i t h E w a l t i n s p r a y areas.
DAOt Nt eAmLDp t iEnLMg ORt oE L o c a t e
GOofvf iecrenrm ernet CH oe nr ct ur al ecst i n g
GC7E3l1Oi Rf tGPoEennnWH. Pe&iingeEhsUt Ns ,BIClEvPda..EWALT SR.
Parents of George Ewalt af na dm i fl ya msiiltiua ar t iwoint h
ATEtNt e mEYpCtKi n g t o L o c a t e
Inspector re Monsanto
W2 4IL8 7L1IAMV i aA. SaFnAIRFCeLrOnUa Gn dHo* Mission Viejo, California 92692
AFRtEt eDmFpAtLi nAgNA t o L o c a t e
Wa riet ha s Danny Ford i n s p r a y e d
WILLIAM F. FALSEY* 6706 Lakeview Drive Lake C ity, Michigan
OTIS E. FANCHER Attempting to Locate
Bio-Test Labs
FARMER, CAPT. Attempting to Locate
With Danny Ford in sprayed areas
L. E. FAST
WILLIAM FENNER*
JJHA.ECRKRCS.UOLFNEIVSS,ICLHLIENERC, . ARK.
HB1 E8iT9r a9TmY R, FaMOpAhi dYioDs ARoad
Cp( Saherretins eSrmF oaayrnddda')s g oBouds i nf reisesn d
THOMAS FORBES MP ho inleasdt ae rl py hAi av,e n uPea .
F riend o f George Ewalt who served in same area in Vietnam
JOHN J . FORD* W15i l Wm iinngt et or bn u, r yD eCl aiwr ac rl ee
K6 5E0R7RYS &e c oJErAe NERTdT. E FORD Lam bertville, Michigan
Brother of Danny Ford
6
RAY & ROSE FORD 13478 South County Line O tt oHwiag hwLaayk e , M i c h . 4 9 2 6 7 MARGARET FORLANO First Street Ft. Dix, N.J. JOSEPH W. FOWLER Attempting to Locate E( i/n4 Fj Ra Ai lN)KS
JOHN P. FRAWLEY*
H. G. FREDERICKS* VAL K. GAERTNER JAEtSt Se Em pGt Ei nRgSHBtEoRGL o c a t e Er. D. G ladney AE at tsetmSptt.i n gL otuoi s ,L oMc ao.t e A. W. GLENN HAROLD GILL*
C40H0E9RYLS h Ga wONnDeEe KT r a i l F t . W o r t h , TX 7 6 1 3 5 CHARLES E. GRANITO* RAYMOND A. GUIDI* M42e0m pEhsisse, x TPe nl ancees s e e COLONEL HAIG Attempting to Locate WALTER D. HARRIS*
n
Danny Ford's Parents
Sister of George Ewalt Gr eo vTt .-H CAo ng rt ri ca uc tl t uOrfef i c e r Vw42iie3t thdn aCLmoammbbaito tSt eu pipnl y , Chief toxicologist cHl iaeaurbscaiultliieotsyn, ari sne sdumeasny
Govt. Contract Officer re Monsanto With Ewalt in Vietnam
Dow a n a l y t i c a l c h e m i s t who a l l e g e d l y d e v e lo p e d analytical method for determination of 2 , 3 , 7 , 8 TCDD i n ' 6 4 . Danny Jordan's s is t e r
Was w i t h E w a l t i n s p r a y area
1 99 ALLERTON RD. NAUGATUCK, CONN. E. ROSS HART DAVID G. HELM* K5 0a0n9s a sF oCr ei st yt , K a n s a s RICHARD HICKMAN* Route 4, No. 10 Yocum Rd. Rogers, Arkansas
JESSE HILSEN PAUL E. HOFFMAN* B1 2a0r2r i nLgakt oe n ,S h oI rl lei nDoriisv e N o r t h GRAYDON HOLDEMAN* B5 E2 0N3JAMBLINOOBM.FIEHLODLDESRT*. MIDLAND, MICH.
H1 6A2R6RYDHr Oy dLeLnANDWay C r o f t o n , MD RAY HOLMES*
G. HOLSING Dc O/ oNALBDe l lHOTLTe l e p o n e o f PA 100 East Armat P h i l a d e l p h i a , PA VERNON HOUCK F22. 0 GWER. ARTDy l e&r VADA HUKILL Magnum, O k l. 73554
Dow g o v e r n m e n t s a l e s Mgr. re Dow's attem pts t oi n csleuldl i npgr ohdeurcbt si c i d e s to the government
Dow M e d i c a l D i r e c t o r r e h ealth e ffe c ts in workers, f a i l u r e to warn and la c k o f minimum e f f e c t l e v e l . Friend of Lam biotte's
Dwohwo pc ol annt rt a cs ut epde r v i s o r chloracne; re health we fafrne c tosf Danodw kf an iolwulreed g et o op fr o dDui oc xt si n i ni n 1 9en6 4d George E w alt's Foreman '80
CDL Danny Jordan's In-Laws
8
THOMAS R. HUNT RAPHAEL H. HUSTON Attempting to Locate APEtTt eEmR pItNi nFAg NTt Eo L o c a t e GEORGE JACKSON cP10/ho0i l aBEdaeesl ltl p ATh rieaml e,apthPoAn e o f PA JAOpHtN. JBENNINGS 12 Lansdowne Avenue Lansdowne, Pa.
DAVID JORDAN*
2LY0 8NNEB r aKeEsLwLEo oRd A u s t i n , TX 7 8 7 0 4 R. EMMET KELLY* 6S6T5. SLOO.UISSK, INMNOE. R VAN A. KELLY Philadelphia, Pa. Atempting to Locate GEORGE C. KEMPSON* 143 South Gore Webster Groves, Missouri E1U2 8G1ENEN. EW. aKgEnNerAGAR*oad E ssexville, Michigan
FRANCIS KENNEDY* WILLIAM KIDD CARL & CARLA KING T3 3o-l4e 2d o ,RoOmhakioer
NIOSH George Ew alt's Foreman late '70s to early '80s GHei gohr g eS c hEowoall t f rwiheon dwaos f in Vietnam at same time and knows h is medical problems. Friend of Danny Jordan's Monsanto With Ewalt in Vietnam
De nowv i reomnpml oeynetea l re persistance, toxicity and l i a b i l i t y issu e s
Closest friends of the w(Di tahnnyC)h rFi so rwd sh;en s ht he e ywas Ff oourndd' s o ul etg t hwaa ts Dc aannn y cpeari no u she anwdas hoi wn . mAucdhd r e s s may a ls o be 3320
J . 0 . KING* J . M. KIRGIS A. Y. KISTNER KAAt tNeSmASp t Ci nIgTY,t o MLO.o c a t e FRANK W. KLEMAN ASTt t. e mLOp tUiInSg, Mt oO. L o c a t e GEORGE KLINE J . KLINGMAN PHILIP LANDRIGAN* JULES LAM 39 Brandon Rd. Newport News, Va. MICHAEL LAMBIOTTE 18 Melford Rd. Newport News, Va. 23601 JR.. KR.. NLEoA. SU2RE- * Box 157 Makanda, I llin o is FRANK LEMAK* P. R. LITTLE HAROLD A. LLOY DR. ANNETTE LYNCH W i sLs aanhei c k e n & S c h o o l h o u s e Philadelphia, Pa. J . R. MALLET W. MALONEY DKBAoiVxtEt e2r6MyANNP o i n t , Me. 0 3 9 0 5 JTHe eOpMASC oMr pA.RKWOOD* 940 N. Coe. Blvd.
10
Romaker Road
Govt. Contracting Officer re T-H A g r ic u ltu r e
David Lambiotte's Uncle BL raomtbhieort t eo f D a v i d
Ewalt's daughter's psychologist VbEeimefptonlroaeyme rando f a Lf taemr b i o t t e P a iynrcoolml e Rreec o Dr dasnnyandForl do s t
lUSSt)
Toledo, Ohio
ROBERT E. MASKILL* 41 East 53rd S t r e e t Kansas City, Missouri RICHARD J . MARRESE* JAMES MASON J1O2HNT aMn nASeOr sN* Dean LE ne ag ltahnedr h e a d , S u r r e y L. G. MAUREY Attempting to Locate PAUL MAYFIELD Attempting to Locate MA.t t eMmcCpAt Li nLgEY t o L o c a t e W12ILLRIiAdMg e J .C rMe scCt ACRVo uILrLt E* C hesterfield, Missouri D5 O5 2N2ALDW hMictCe Oh La Ll lISTSEtRr *e e t Midland, Michigan wC9 6Ai 5lL1lIFi aOBmRLANCdIAK. MGcOeLDl r oRyD*. J1U8D9Y9 MR caKpIiNdSsEYRoad Hiram, Ohio SGT. TIMOTHY MEDDOR
C6 9O1L4. WBR. UCMEERMCEERYEWRSAY ST. LOUIS, MO. ROY MEYERS
Attem pting to Locate
CHARLES E. MTNARTCK*
RONALD MOODY
li
T-H A g r ic u ltu r e ; l i a b i l i t y issues
Inspector re Monsanto Deposed February 11, 1983 Deposed March 30, 1983. Deposed July 13, 1983 BFoursdi n aens ds pc laorst en e rf r ioefn dC h r i s (See McKimnley) VS ei ertvneadm w i t h J o r d a n i n Inspector, re Monsanto
Ranch Hand W i t n e s s1 3 6 9 1
SHERRY MOSHER T1 8o4l 3e 3d5o , WOi hnicoh e s t e r Rd.
Business manager of the ks ternanienl . on SCt rhersiss aFnodrd
A ddress may a l s o be
DEBDAS MUKERJEE*
BOB NOBER 71 Lempa Road H o lla n d , Pa
Was w i t h E w a l t i n V i e t n a m
W71I1LLIWA.MMRe.adNoUwMbMr oYo*k D r i v e Midland, Michigan
JACKIE OCHS
Photographic exhibits
cP/. o 0 G. RBEOENX M22O9UNTAIN
POST
FILMS
& personal observations & investigations
TURNER FALLS, MA.
BRIAN O'CONNOR B5 5r4o5n xN, eNt h. Ye r. l a n d A v e .
Friend of the Ryans
J . F. O'CONNOR
SGT. THOMAS O'DONNELL
Served with Jordan in Vi etnam
DR. OERTNER
J . E. PALLARD
FRANCIS PANNETON
L. A. PARDEE
PHIL PENN
Amounts - doing away of herbs - has tapes tt oo Vd eetteerrma ni ns e I eI x' sp o s u r e
REBECCA PEPPER 6718 Silvermine Drive A# 1u0s0t4i n , TX 7 8 7 3 6
Neighbor of Jordan's
JB6A6rC4oKoFkEof.ri eePlsdEt T, EGRWrSoOivsNec oCn si irnc l e
Former Dow e m p l o y e e who addressed industry representatives at March, 1965 meeting concerning rabbit ear testing
13632
12
F. H. PLACET Attempting to Locate WILLIAM L. POPHAM DONALD PURDY* 160 Fredericksberg Drive Avon Lake, Ohio THOMAS RAFFERTY B2 2r2o1o k5l y6 n ,D rNi Yv e 1 1 2 3 4 VIRGIL B. ROBINSON* 2620 Quail H ill Drive Upper St. C lair, Pa. 15241 V. K. ROWE*
ROBERT R. RUMER* GC46El CeWnILdianRlgeUf,Si eSElMdLOL. *Row M82AURFEi Ef Nt h RYAAvNe . K ings P ark, New York MICHAEL RYAN K54i n Wg so oPdasrdka,l e NA.Yv.e . VICKY RYAN K54i nWg so oPdasrdka,l e NA.Yv.e . HFEl oNRr Yi d aSADLER UMBERTO SAFFIOTTI*
13
GU no vi rt o. y Ca lo n t r a c t O f f i c e r r e C o n s u l t a n t t o NACA
With Mike Ryan in Vietnam
DT oowx 'isc ofloorgmi es rt C- hliieaf b i l i t y issues as well as kc an uo ws al et di ogne qo fu eesxt ti roenms ;e D o w ' s wt oaxr ni c. i t y and f a i l u r e t o
kSnc ohwo so l KPerr irnyc' si p ae dl uwc haot i o n Mike Ryan's Father Kerry's Grandmother Boyhood friend of L a m b io tte 's who was with him in Vietnam Government causation witness with factual testimony re government cl ioanbt ri al ictty d iesfseun es se , and issuance of Bionetics Laboratories Report.
13693
DR. SALTER 97 York S treet York, Maine 03909 ED SAWGRASS PSRUhiSpiAll Neand SeCSl pAtNhrLeiOae Nt, P a . W1 4I1L1LIAWM. RS .t . SCAHnAdMr eBwRAs * Midland, Michigan
ARTHUR J . SCHLESSINGER O78LGAU nSiCvHeNrEsLi Lt y H e i g h t s Dr . Stony Brook, N.Y. 11790 W. SCHUBACK LAPIN 0 . SCOTT R. B. SCOTT RICHARD SCOTT
SGT. SHARKEY
DEXTER B. SHARP* S1 3t .0 4 2L oWu iesa, t hMeor.f i e l d D r i v e A. E. SIDWELL* LARRY SILVERSTEIN
B1 E8 9T9TY RSaMpAi YdDs AR d . Hayram, Ohio J . G. SMERALDI*
14
Dr. who t o l d Lam biotte to stop working.
Sister of George Ewalt Df aowi l ufro re m et or we marpnl o aynede re business of selling gh oe vr ebrinc mi deenst . t o t h e Neighbor of the Ryans
Hercules employee. Drafted with Lambiotte and saw in Vietnam David Lambiotte's platoon Sergeant in Vietnam
Hercules employee.
MDDi sooaswwruceafhosn, rdma1n9oedr6t
h5
e eh
rmme apellletiothayi nbe
egi
sl
irteayt
e f f e c t s to Dow e m p lo y e e s .
WBF ouhras tdi n' Fse ,sosr pd psl uaswr tengnoet ordst h r-f or uiCeghnhrdi .s and personal s tr a in s
136S4
CAPT. SMITH
With Ewalt in spray areas
PLATOON LT. SMITH
With Ewalt in spray areas
TOM K. SMITH
ROBERT SNODGRASS H u n t i n g t o n , W. V a.
With Danny Ford in Sprayed areas
HOWARD C. SPENCER* S1u1n0 0 8C iCt yam, eoA rDi zroinvae 8 5 3 5 1
Developed rabbit ear test ei nm p1l9o4y1e ew. h i l e a Dow
L. P. SEITZ
A. JOHN SPEZIALE* R31e1dwNoo. d UCmibteyr,l a nCda lAi fvoernnu ei a 9 4 0 6 1
J8SO0tH0. NNLA.o.uLiSsi nT, EdPbMHeirEsgNshoS*u Br il v d .
FREDERICK G. STEWARD* T17u3s cWa loooodsl aan, d AFlaobraemsat , 3 5S4e0c5t i o n 3
CHARLES N. STEWART*
M5F2It1C. HAWBEooLmrtbhSeTrRTAReNxoGaaEds
Friend of Danny Jordan
FREDERICK STRANSKY 53 S. Mallard Selden, N.Y.
Mike Ryan's B roth er-in Law
SGT. STRAWBERRY
Was w i t h E w a l t i n s p r a y areas
D24EIRADlmREa ASTvReA. NSKY Selden, N.Y.
T- e aa c hs pe re c-i akl ni sowt s i nK elrerayr nRiynagn disabilities
P53ATSR.ICMIAa lSl aTrRdANSKY Selden, N.Y.
Nurse and Family Cfoaumnisleyl l e r f o r Ryan
J7A1C2 KS ShToRrUtM*S p o on C i r c l e North Carolina
JOHN S . SULLIVAN
W53I0N0FIEWLeDs tWp a. t hSUNWDaEyRLAND* Bethesda, Maryland DANIEL W. SWEET* MW21Ii0LlTmONiN.n gASt o.pnr T,i nAgDVEeVSl a*awl al er e Road C30L9INTPOiNe z TAAYvLeO. R
Newport News, Va.
R. D. THOMPSON W3 1I8LLIGAEMORTGHI NOAMPASOVNE*. SANTA MONICA, CAL. A. L. TREISBECK
DAN TWI SS Woodland S tr e e t S y lv a n ia , Ohio
DAN T W I F F
4910 Woodland Sylvania, Ohio WILLIAM R. UDELL 60 Tealwood C r e v e C o e u r , MO. EDWIN T. UPTON
W. VANDERVENTER* JANE WARD T3 5e2m7p eMr.a n1c5e1, M i c h . 4 8 1 8 2 ROBERT T. WEBBER* S4 t M. eLdioau iDs ,r i vMe i s s o u r i 6 3 1 4 6
Business p a rtn e r of David L a m b io tte 's
Hercules employee. Depos ed . Union c o m m i s s i o n man a t Danny Ford's job. Also a frien d of D an's. Has ci no fnotrrma catt i o(nc u ar br eonutt) u anni odn personnel m atters. See also Twiff. C o m m i t t e e man a t AMC J e e p See Twiss above
T-H l i a b i l i t y i s s u e s DA epproi ls e d8 , A1p9r8i3l 7 , and
Neighbor of Fords
13698
16
*m
ARDoAuMt e W5EN-KUSBox 904 Waupaca, Wisconsin
wdS ueafrpenpn;l
yd
af oanrntmds 'e
d r
fi
asDtierlfuiebrnues
t e
itoo
n
,
M ilitary Supply Office
employee.
BUTCH WESTERLAND
Served with Jordan in Vietnam
HARTLEY WILDER
SGT. J . WILLIS
Served with Danny Jordan in Vietnam
MARK G. WILTSE*
N. WIRZ
W4 9IL- 2B1URBWa Or tHoLnGAMPUl aTHc e Sylvania, Ohio
hUFeon
irohdna'
ds
S
-tt
e h
wek
na ecrwat
n
cDa etarn
Dwaannhdne ny
the wages at the time
and t h e c h a n g e s in Dan
L. K. WOOLFOLK
JOHN WRIGHT
AR.t t eWmRIpGtHi nTg t o L o c a t e
Govt. Inspector re Monsanto
R. T. YATES
YORK HOSPITAL Y15o r Hk ,o sMp ai tianel D r .
Former employer of Lambiotte
MITCHELL ZARON K ettering Labs C3 2i2n3c i En dneant iA, vOe .h i o .
CHARLES P. ZORSCH* Route 5, box 30 P a c i f i c , MO.
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AGENT ORANGE PLAINTIFFS' MANAGEMENT COMMITTEE
17
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CERTIFICATE OF SERVICE
EDWARD F. HAYES, III, hereby certifies that the foregoing was duly served upon the parties this date by Federal Express at the addresses below listed:
Dated: April 3, 1984
SERVICE LIST
Rivkin, Leff, Sherman & Radler Attorneys for Dow Chemical Co. 100 Garden City Plaza Garden City, N.Y. 11530
Cadwalader, Wickersham & Taft Attorneys for Diamond-Shamrock One Wall Street New York, N.Y. 10005
*
Shea & Gould Attorneys for Uniroyal, Inc. 330 Madison Avenue New York, N.Y. 10017
Budd, Larner, Kent, Gross, Picillio & Rosenthal Attorneys for Thompson Chemical 33 Washington Street Newark, N.J. 17102
Kelley, Drye & Warren Attorneys for Hercules, Inc. 101 Park Avenue New York, N.Y. 10178
Townley & upaiKe Attorneys for Monsanto Co. 405 Lexington Avenue New York, N.Y. 10017
Arthur, Dry & Kalish Attorneys for Uniroyal,Inc 1230 Avenue of the Americas New York, N.Y. 10020
Clark, Gagliardi & Miller Attorneys for T&H Agriculture 99 Court Street White Plains, N.Y. 10601
United States Attorney's Office United States Dept, of Justice Attorneys for United States Safeway Building, Rm 9040 Washington, D.C. 20530
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UNITED STATES DISTRICT COURT EASTERN DISTRICT OF NEW YORK
IN RE
"AGENT ORANGE PRODUCT LIABILITY LITIGATION
X
MDL No. 381 (All Cases)
X
SECOND LIST OF MONSANTO FACT WITNESSES
To w n l e y & U p d i KE
CHRYSLER BUILDING 4 0 5 LEXINGTON AVENUE
N E W Y O R K , N . Y. 1 0 1 7 4
TELEPHONE
(2121 6 8 2 - 4 5 6 7
UNITED STATES DISTRICT COURT EASTERN DISTRICT OF NEW YORK -------------------------------------- X
IN RE
"AGENT ORANGE"
PRODUCT LIABILITY LITIGATION
X
MDL No. 381 (All Cases)
SECOND LIST OF MONSANTO FACT WITNESSES
Defendant Monsanto Company ("Monsanto"), pursuant to the schedule established by Magistrate Scheindlin, hereby submits a second list of fact witnesses who might give testimony at trial in support of Monsanto's claims. This list supplements the First List of Monsanto Fact Witnesses Identified Pursuant to Order of the Court Dated January 10, 1984, which was served on February 29, 1984.
Monsanto reserves the right to amend the descriptions that follow of the general nature of the testimony to be given, should Monsanto's continuing trial preparation indicate any such amendment is appropriate.
1. Richard A. Atkinson. 4242 Kanawha Turnpike South Charleston, West Virginia Monsanto's production of 2,4,5-T in the 1960's; Monsanto's efforts to reduce worker exposure to its 2,4,5-T process; Monsanto's efforts to reduce or to remove dioxin in its 2,4,5-T process; the health experience of Monsanto workers involved in the 2,4,5-T process.
1 3 '7 o o
2. Philip B. Balderson.
101 Stewart Park Cross Lanes, West Virginia
Monsanto's analytic efforts to detect and to measure the presence of dioxin in its 2,4,5-T.
3. Robert Baynard.
231 Jeffrey Lane Newton Square, Pennsylvania
The marketing and sale of herbicides containing Monsanto-manufactured 2,4,5-T, both to the United States Government and to commercial customers; the health experience of persons who used or were otherwise exposed to herbicides containing 2,4,5-T.
4. Stanley C. Beach.
760 Sotano Drive Sacramento, California 95833
The methods and procedures used to aerially disseminate herbicides in Vietnam; the duties and responsibilities of a flight mechanic of a C-123 airplane during herbicide operations in Vietnam; the health experience of persons in Vietnam who used or were otherwise exposed to herbicides containing 2,4,5-T.
5. Donald J. Birmingham.
19811 Wedgewood Drive Gross Point Woods, Michigan
The United States Government's investigation of the health experience of Monsanto workers involved in the 2,4,5-T process in the 1950's and/or exposed to the materials formed during a runaway reaction in the manufacture of sodium trichlorophenate at Monsanto's Nitro, West Virginia plant in 1949.
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6. Russell Bishop.
Ambler, Pennsylvania
The health experience of commercial formulators of 2,4,5-T produced by Monsanto.
7. Carl D. Bohl.
455 Wildwood Parkway Ballwin, Missouri
The historical knowledge of the toxicity of herbicides containing 2,4,5-T and the toxicity of dioxin; the health experience of Monsanto workers involved in the 2,4,5-T process; Monsanto's efforts to reduce or to remove dioxin from its 2,4,5-T process and to reduce worker exposure to that process.
8. John S . Bush, Jr .
2232 North Military Road Arlington, Virginia
Monsanto's contracts with the United States Government for the production of Agent Orange and other military herbicides; the Government's plan to build and to operate an Agent Orange plant at Weldon Spring, Missouri.
9. Robert E. Cox.
203 East Belerest Road Bel Air, Maryland
Visit to Monsanto's Nitro plant in connection with the proposed manufacture of Agent Orange by the United States Government.
10. Eugene A. Cutright.
1474 Maplewood Drive Macon, Georgia
Monsanto's production of 2,4,5-T in the 1960`s; Monsanto's efforts to reduce worker exposure to its
137
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2,4,5-T process; Monsanto's efforts to reduce or to remove dioxin in its 2,4,5-T process; the health experience of Monsanto workers involved in the 2,4,5-T process.
Burnie R. Dallas, Jr.
1775 East 20th Street Apt. D-8 San Bernardino, California
The methods and procedures used to aerially disseminate herbicides in Vietnam; the duties and responsibilities of a flight engineer of a C-123 airplane during herbicide operations in Vietnam; the health experience of persons in Vietnam who used or were otherwise exposed to herbicides containing 2,4,5-T.
Stewart D. Daniels.
Monsanto Singapore Co. PTE Ltd. 2601-2606 Clifford Center Raffles Place Singapore
The manufacture, marketing, and sale of herbicides containing 2,4,5-T, both to the United States Government and to commercial customers; the health experience of persons who used or were otherwise exposed to those herbicides.
Robert A. Darrow.
7613 Baltimore National Pike Frederick, Maryland
The United States Government's development, testing, and use of Agent Orange; the Government's specifications for Agent Orange.
Robert Dennis.
Route 6, Box 302 Yakima, Washington
The methods and procedures used to aerially disseminate herbicides in Vietnam; the duties and
13704
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responsibilities of a pilot of a C-123 airplane during herbicide operations in Vietnam; the health experience of persons in Vietnam who used or were otherwise exposed to herbicides containing 2,4,5-T.
15. Jon R. Dudenhoeffer.
5639 King Road Erie, Pennsylvania
The methods and procedures used to aerially disseminate herbicides in Vietnam; the duties and responsibilities of a navigator of a C-123 airplane during herbicide operations in Vietnam; the duties and responsibilities of a targeting officer for herbicide operations in Vietnam; the health experience of persons in Vietnam who used or were otherwise exposed to herbicides containing 2,4,5-T.
16. Jack D. Early.
8024 Lakenheath Way Potomac, Maryland
Monsanto's contacts with the United States Government in the 1960's regarding pesticide regulation; the activities of the National Agricultural Chemicals Association.
17. Henry Good.
The methods and procedures used to aerially disseminate herbicides in Vietnam; the duties and responsibilities of a pilot of a C-123 airplane during herbicide operations in Vietnam; the duties and responsibilities of a targeting officer for herbicide operations in Vietnam; the health experience of persons in Vietnam who used or were otherwise exposed to herbicides containing 2,4,5-T.
18. Paul D. Halley.
The involvement of the West Virginia occupational health authorities in an investigation of the runaway reaction that occurred in 1949 during the manufacture
13705
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si
of sodium trichlorophenate at Monsanto's Nitro, West Virginia plant, including efforts to identify and to determine the toxicity of materials formed during that reaction; the health experience of Monsanto workers exposed to those materials and/or the 2,4,5-T process in the 1950's.
!.i19. Frank Helmer.
2825 FlamevoC'd Drive
Monsanto's manufacture of 2,4,5-T at its Nitro, West Virginia plant; improvements in Monsanto's manufacturing process for 2,4,5-T.
20. Paul F. Hoffman.
1202 Lakeshore Drive North Barrington, Illinois
Monsanto's marketing and sale of herbicides containing 2,4,5-T in the 1960's, both to commerical customers and to the United States Government; the health experience of persons who used or were otherwise exposed to herbicides containing 2,4,5-T.
21. Charlie Hubbs. Camp Springs, Maryland
The methods and procedures used to aerially disseminate herbicides in Vietnam; the duties and responsibilities of a pilot of a C-123 airplane during herbicide operations in Vietnam; the health experience of persons in Vietnam who used or were otherwise exposed to herbicides containing 2,4,5-T.
22. Allan M. Jokela. 1511 North Rock 38th Road Rock, Michigan
The methods and procedures used to aerially disseminate herbicides in Vietnam; the duties and
13706
responsibilities of a navigator of a C-123 airplane during herbicide operations in Vietnam; the duties and responsibilities of a targeting officer for herbicide operations in Vietnam; the health experience of persons in Vietnam who used or were otherwise exposed to herbicides containing 2,4,5-T.
23 . George C. Kempson.
Monsanto's marketing and sale of herbicides containing 2,4,5-T, both to the United States Government and to commercial customers; the health experience of persons who used or were otherwise exposed to herbicides containing 2,4,5-T.
24. Kettering Laboratory.
University of Cincinnati Cincinnati, Ohio
Work performed for Monsanto by the Kettering Laboratory in the 1950`s regarding the health experience of Monsanto workers exposed to materials formed during a runaway reaction in the manufacture of sodium trichlorophenate at Monsanto's Nitro, West Virginia plant in 1949 and/or to the 2,4,5-T process, including the treatment of affected workers and efforts to determine the toxicity of the materials formed during the runaway reaction and of 2,4,5-T and its process intermediates.
25. Paul Lacey.
117 Rosetta Court Springdale, Ohio
The methods and procedures used to aerially disseminate herbicides in Vietnam; the duties and responsibilities of a flight mechanic of a C-123 airplane during herbicide operations in Vietnam; the health experience of persons in Vietnam who used or were otherwise exposed to herbicides containing 2,4,5-T.
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26. John S. Leary, Jr.
2002 Sea Cove Court Nassau Bay, Texas
Contacts in the 1960's between Monsanto and the United States Government regarding the toxicity of 2,4,5-T.
27. Charles F. Luecke.
12747 Spruce Pond Drive St. Louis, Missouri
Monsanto's manufacture, marketing, and sale of herbicides containing 2,4,5-T, both to the United States Government and to commercial customers; the health experience of Monsanto workers involved in the 2.4.5- T process and persons who used or were otherwise exposed to herbicides containing 2,4,5-T; the United States Government's specifications for Agent Orange and Monsanto's compliance with them; the historical knowledge of the toxicity of herbicides containing 2.4.5- T and of the toxicity of dioxin; Monsanto's efforts to identify impurities, including dioxin, created in its manufacture of 2,4,5-T.
28. Charles E. Minarik.
P.O. Box 682 W. Harwich, Massachusetts
The United States Government's development, testing, and use of Agent Orange; the Government's specifications for Agent Orange.
29. John Mullendore.
1020 Grove Evanston, Illinois
Monsanto's manufacture of phenoxy herbicides; contact with the United States Government regarding dioxin.
13708
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30. V e r n e L. R h o d e s .
2120 Windport Lane St. Louis, Missouri
Monsanto's production of 2,4,5-T in the 1960's; Monsanto's efforts to reduce worker exposure to its 2,4,5-T process; Monsanto's efforts to reduce or to remove dioxin in its 2,4,5-T process.
31. Frank S. Serdy.
13275 Windy Gate Lane Creve Coeur, Missouri
The United States Government's field testing of herbicides in Thailand; the health experience of persons who used or were otherwise exposed to herbicides containing 2,4,5-T.
32. Robert G. Sido.
7611 Shirley Drive Clayton, Missouri
The United States Government's specifications for Agent Orange and Monsanto's compliance with them; registration of Monsanto products containing 2,4,5-T.
33. Anthony Sinclitico.
7800 William Road Baltimore, Maryland
The United States Government's specifications for Agent Orange.
34. Milt Smid.
#3 Zinzer Court St. Louis, Missouri
The United States Government's specifications for Agent Orange and Monsanto's compliance with them.
13709
n
C;
Tom K. Smith.
Monsanto's contracts with the United States Government for sale of herbicides containing Monsanto-manufactured 2,4,5-T; Monsanto's manufacture and sale of herbicides containing 2,4,5-T.
Robert E. Soden.
15998 Kettington Road Clarkson Valley, Missouri
The health experience of Monsanto workers exposed to the 2,4,5-T process in the 1950's; Monsanto's efforts to determine the toxicity of 2,4,5-T and its process intermediates; Monsanto's efforts to reduce worker exposure to the 2,4,5-T process.
John R. Spey.
850 Tarpon Drive Fort Walton Beach, Florida
The methods and procedures used to aerially disseminate 'rbicides in Vietnam; the duties and responsibilities a pilot of a C--123 airplane during herbicide
operations in Vietnam; the health experience of persons in Vietnam who used or were otherwise exposed to herbicides containing 2,4,5-T.
James E. Springgate.
13060 East Sunset Drive Los Altos Hills, California
Monsanto's production of 2,4,5-T in the 1960's; Monsanto's efforts to reduce worker exposure to its 2,4,5-T process; the health experience of Monsanto workers involved in the 2,4,5-T process.
Earl Spurrier.
Madison Building, Suite 301 1155 15th Street N.W. Washington, D.C.
The methods and procedures used to apply herbicides obtaining 2,4,5-T for weed control in the United
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13720
States; the health experience of persons who used or
w2 e, r4e, 5 o- Tth. erwise exposed to herbicides containing
40. Jack C. Strum.
712 Short Spoon Circle Rocky Mount, North Carolina
Monsanto's production of 2,4,5-T in the 1960`s; Monsanto's efforts to reduce worker exposure to its 2,4,5-T process; Monsanto's efforts to reduce or to remove dioxin in its 2,4,5-T process; the health experience of Monsanto workers involved in the 2,4,5-T process.
41. Frank E. Take, Jr.
480 Hillbrook Drive Ballwin, Missouri
Monsanto's manufacture of 2,4,5-T at its Nitro, West Virginia plant; the United States Government's specifications and Monsanto's compliance with them; Monsanto's efforts to identify impurities, including dioxin, created in its manufacture of 2,4,5-T; Monsanto's efforts to reduce or remove dioxin in its 2,4,5-T process; the health experience of Monsanto workers involved in the 2,4,5-T process.
42. Wayne E. Vandeventer.
The United States Government's specifications for Agent Orange and Monsanto's compliance with them.
43. Richard C. Wallace.
P.O. Box 230 St. Albans, West Virginia
The health experience of Monsanto workers involved in the 2,4,5-T process.
13711
44. R o b e r t T. W e b b e r .
4 Media Drive St. Louis, Missouri
Monsanto's efforts to reduce worker exposure to its 2,4,5-T process.
45. Elmer P. Wheeler.
110 Cool Springs Drive Camden, South Carolina
Monsanto's efforts to identify impurities, including dioxin, created in its manufacture of 2,4,5-T; Monsanto's efforts to determine the presence of dioxin in its 2,4,5-T process and to reduce or remove it from that process; the historical knowledge of the toxicity of herbicides containing 2,4,5-T and the toxicity of dioxin; the health experience of Monsanto workers involved in the 2,4,5-T process and of persons who used or were otherwise exposed to herbicides containing 2,4,5-T; contacts with United States Government representatives and others outside Monsanto concerning all of the above.
46. Herbert Woodcock.
The methods and procedures used to aerially disseminate herbicides in Vietnam; the duties and responsibilities of a navigator of a C-123 airplane during herbicide operations in Vietnam; the health experience of persons in Vietnam who used or were otherwise exposed to herbicides containing 2,4,5-T.
47. Younger Laboratories.
Monsanto's efforts to determine the toxicity of 2,4,5-T and its process intermediates.
New York, New York March 26, 1984
TOWNLEY & UPDIKE
By : joy , /tA,, ( .
A Member of the Firm
Attorneys for Defendant Monsanto Company
405 Lexington Avenue ` New York, New York 10174
(212) 682-4567
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137
CERTIFICATE OF SERVICE
I HEREBY AFFIRM THAT I am an attorney duly admitted to practice in the State of New York and in the Eastern District of New York. I HEREBY CERTIFY that on March 26, 1984 I caused to be served a true and correct copy of the Second List of Monsanto's Fact Witnesses by courier on all counsel on the attached service list.
DANIEL COBRINIK
137
AGENT ORANGE SERVICE LIST
Wendell B. Alcorn, Esq. Cadwalader, Wickersham & Taft One Wall Street New York, N.Y. 10005
Leonard L. Rivkin, Esq. Rivkin, Leff, Sherman & Radler 100 Garden City Plaza Garden City, N.Y. 11530
Thomas Beck, Esq. Arthur, Dry & Kalish, P.C. 1230 Avenue of the Americas New York, N.Y. 10020
William Krohley, Esq. Kelley, Drye & Warren 101 Park Avenue New York, N.Y. 10178
Paul V. Esposito, Esq. Lewis, Overbeck & Furman 135 South LaSalle Street Suite 1060 Chicago, Illinois 60603
Morton G. Silberman, Esq. Clark, Gagliardi St Miller The Inns of Court 99 Court Street White Plains, N.Y. 10601
Richard Goldstein, Esq. Shea & Gould 330 Madison Avenue New York, N.Y. 10017
Howard Lester, Esq. Lester Schwab Katz St Dwyer 120 Broadway New York, N.Y. 10005
David R. Gross, Esq. Budd, Larner, Kent, Gross,
Picillo St Rosenbaum 33 Washington Street Newark, New Jersey 07102
PLAINTIFFS
David J. Dean, Esq. Dean, Falanga, Sinrod & Rose 1 Old Country Road Carle Place, N.Y. 11514
Benton Musselwhite, Esq. Law Offices of Benton Musselwhite, Inc. 609 Fannin - Suite 517 Houston, Texas 77002
Thomas Henderson, Esq Baskin St Sears Frick Building - 10th Floor Pittsburgh, Pa. 15219
Victor J. Yannacone, Jr., Esq. Yannacone St Yannacone Post Office Drawer #109 62 Rose Avenue Patchogue, New York 11772
Stephen J. Schlegel, Esq. Schlegel St Trafelet, Ltd. One North LaSalle Street Suite 3900 Chicago, Illinois 60602
Irving Like, Esq. Reilly, Like St Schneider 200 West Main Street Babylon, New York 11700
GOVERNMENT COUNSEL
Arvin Maskin, Esq. Department of Justice Safeway Building -.Room 904 D 521 12th Street, N.W. Washington, D.C. 20530
Hon. Raymond J. Dearie United States Attorney
By: L. Kevin Sheridan" Executive Assistant U.S. Attorney U.S. District Court Brooklyn, New York 11201
OTHERS
Sol Schreiber, Esq. Special Master Milberg, Weiss, Bershad,
Specthrie & Lerach One Penn Plaza Suite 4915 New York, N.Y. 10119
Clerk of Panel Judicial Panel on Multidistrict Litigation 1120 Vermont Avenue, N.W. Suite 1002 Washington, D.C. 20005
Hon. Shira Scheindlin Magistrate
U.S. Courthouse 225 Cadman Plaza East Brooklyn, N.Y. 11201
Agent Orange Plaintiffs' Management Committee 26 Court Street, Room 905 Brooklyn, New York 11242
V.
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5
UNITED STATES DISTRICT COURT EASTERN DISTRICT OF NEW YORK
In re "AGENT ORANGE"
Product Liability Litigation
x
P' j
u-s. toi
MDL No. 3 J ft
c " * r
X T-/:.- ''.AJ !>h13
DEFENDANT DIAMOND SHAMROCK CHEMICALS COMPANY'S SUPPLEMENTAL
. LISTING OF FACT. WITNESSES___
Pursuant to Magistrate's Pretrial Order No. 16 and Magistrate's directions at the March 7, 1984 pretrial conferer defendant Diamond Shamrock Chemicals Company ("Diamond Shamroc sets forth below its list of fact witnesses who may g testimony at trial in support of Diamond Shamrock's claims ; defenses. Diamond Shamrock also joins in Defendants' List Fact Witnesses dated March 26, 1984, which is being served a filed under separate cover.
Diamond Shamrock reserves the right to supplement a amend this list based on information developed in continui: discovery proceedings or other trial preparations, and to call a live witness or use the deposition testimony of any pers listed by any other party. Diamond Shamrock also reserves t right to supplement and amend this list in the "witness list section of the pretrial order following receipt and review plaintiffs' final fact witness list, now due on March 27, 1984.
13716 _/
Name and Present Address
Louis Anderson 220 E. 17th Street Chicago Heights, Illinois 60411
Eugene Bak*
Dr. Donald J. Birminghan* 19811 Wedgewood Drive Gross Point Woods, Michigan
Jack A. Borror*
Dr. Roger H. Brodkin 769 Northfield Avenue West Orange, New Jersey 07052
Lawrence L. Cecil, Jr. 12825 S.W. 69 Gourt Miami, Florida 33156
Edward L. Chandler*
Robert L. Chonoles* Diamond Shamrock Chemicals
Company Berry Avenue at Route 17 North Carlstadt, New Jersey 07072
Howardi E. Everson*
Raymond A. Guidi*
Alfred M. Hauser Diamond Shamrock Chordeals
Company Berry Avenue at Route 17 North Carlstadt, New Jersey 07072
Description of General Nature of Testimony__
Testimony concerning purchases by Riverdale Chemical Company of 2,4,5-T acids and esters supplied by Diamond Shamrock.
Testimony concerning research and investigation of chloracne by U.S. Public Health Service in the 1950's and 1960's, including visits to Diamond Shamrock's former Newark plant.
Testimony concerning medical condi tions at the Newark plant, including: communications with and investigations by the U.S. Public Health Service; and preparation and publication of the article by Bleiberg, _g.al. (1964).
Testimony concerning foreign sales of Diamond Shamrock's 2,4,5-T products, including sales in Colombia.
Testimony concerning manufacturing operations at Diamond Shamrock's former Newark plant, including: the removal of dioxin from trichlorophenol; and the U.S. Public Health Service stud/ of the Newark workers in 1968-69.
Testimony concerning Diamond Sham rock's contractual arrangements with the United States for the sale of Agent Orange.
*. Witnesses designated by an asterisk (*) have been deposed m MDL No.
381.
-2- 13717
Name and Present Address
Melvin Hochberg*
Stanley B. Honour* 829 Eggleston Port Collins, Colorado 80524
Francis R. Kenned/* 2711 Bernadette Lane Houston, Texas 77043
Dr. Marcus M. Ke/* University of Texas Health
Science Center P.O. Box 20186 Houston, Texas 77025
James 0. King* P.O. Box 900 Alpharetta, Georgia
Jane Lewis* 5125 Tsnple Hills Road
Tsnple Hills, Maryland 20748
Rl c,hard,
J.
* Marrese
Dr. Richard W. McBurney 315 Steeple Chase Drive Irving, Texas 75062
Description of General Nature of Testimony
Testimony concerning foreign sales of Diamond Shamrock's 2,4,5-T products, including sales in Oolanbia.
Testimony concerning manufacturing operations at Diamond Shamrock's former Newark plant, including: the
development, installation and opera tion of a method for removing dioxin from trichlorophenol; visits to the
Newark plant by the ULS. Public Health Service in the 1960's; and the produc
jtion and shipment of Agent Orange
pursuant to contracts with the United
States.
!i
Testimony concerning research and in- ;
vestigation of chioracne by U.S. Pub
lic Health Service in the 1960's,
including visit to Diamond Shamrock's I
former Newark plant.
j
Testimony concerning domestic and !
foreign sales of Diamond Shamrock's
2,4,5-T products, including sales of
Agent Orange pursuant to contracts
with the United States.
!
Testimony concerning the procurement j
and production of Agent Orange pur- !
suant to the Defense Production Act,
including directives and priority rat- :
ings issued by the United States.
Testimony concerning medical conditions at the Newark plant, including communications with U.S. Public Health Service and with treating physicians at Newark.
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Name and Present Address
Dr. lan P. Poland* 2918 Nottingham Way Madison, Wisconsin
Dr. Paul A. Fossick* 46 Winding Way Woodcliff Lake, New Jersey Donald M. Purdy* F. Gordon Steward* Diamond Shamrock Agricultural
Chemicals Inc. P.0. Box H Tuscaloosa, Alabama 35404
Dated: New York, New York March 26, 1984
Description of General Nature of Testimony
Testimony concerning medical study of the workers at Diamond Shamrock's former Newark plant in 1968-69, and research and investigation of trichlo- ( rophenol, 2,4,5-T and dioxin at j National Communicable Disease Center in the 1960's.
Testimony concerning medical study of the workers at Diamond Shamrock's former Newark plant in 1968-69.
Testimony concerning manufacturing operations at Diamond Shamrock's former Newark plant, including: the development, installation and opera tion of a method for removing dioxin from trichlorophenol; the U.S. Public Health Service study of the Newark workers in 1968-69; and the production and shipment of Agent Orange pursuant to contracts with the United States.
Respectfully submitted,
CADWALADER, WICKERSHAM & TAFT
ByifJ lS rzfc 'fy A
\2 /1
A Member of the F i r m - y ^ ^
Attorneys for Defendant
Diamond Shamrock Chemicals
Company
One Wall Street
New York, New York 10005
(212) 908-7000
-4- 13719
AFFIDAVIT OF SERVICE
STATE OF NEW YORK ) : ss.:
COUNTY OF NEW YORK )
JEFFREY SAPER, being duly sworn, deposes and says:
1. I am not a party to this action, am over 18 years of age and reside in Queens County, New York.
2. On March 26, 1984, I served the annexed Defendant Diamond Shamrock Chemicals Company's Supplemental Listing of Fact Witnesses on each of the persons named on the annexed list by depositing a true copy of same enclosed in a postpaid properly addressed wrapper, in an official depository under the exclusive care and custody of the United States Postal Service within the State of New York. The copy to the Agent Orange Plaintiffs' Management Committee was sent by Federal Express.
Sworn to before me this day of March, 1984 .
Notary Public
CoNmQMomutIaCairslHysifiAioPenEudNbLEoIlnix.Mcp,3NAi1Sre-Cet4wasK6t4eMIY6N9ooa6rrfG5kcNOhCeR3wo0Du,OYnlt9Noy.rvkn. j*/--
7 %fxev
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Saper
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FOR DEFENDANTS
SERVICE LIST
r
Leonard L. Rivkin Rivkin, Leff, Sherman & Radler
(for DOW CHEMICAL) 100 Garden City Plaza Garden City, New York 11530
Morton G. Silberman Clerk, Gagliardi & Miller
(for T H AGRICULTURE & NUTRITION COMPANY, INC.) The Inns of Court 99 Court Street White Plains, New York 10601
John C. Sabetta Townley & Updike
(for MONSANTO) 405 Lexington Avenue New York, New York 10174
William Krohley Kelley Drye & Warren
(for HERCULES, INC.) 101 Park Avenue New York, New York 10178
John M. Fitzpatrick
Dil(wfoorrthH,OOPKaExRsoPnL,ASTKIaClSish& & Levy
CHEMICALS CORP.) 2600 The Fidelity Building
Philadelphia, Pennsylvania 19109
Richard Goldstein Shea & Gould 330 Madison Avenue New York, New York
10017
Thomas Beck Arthur, Dry & Kalish, P.C.
(for UNIROYAL) 1230 Avenue of the Americas New York, New York 10020
David R. Gross
Budd, Larner, Kent, Gross, Picillo & Rosenbaum
(for THOMPSON CHEMICALS) 33 Washington Street Newark, New Jersey 07102
Arvin Maskin Department of Justice
(for THIRD PARTY DEFENDANT US Safeway Building 521 12th Street, N.W. Washington, D.C. 20530
L. Kevin Sheridan Executive Assistant
U.S. Attorney Eastern District of New York United States Courthouse 225 Cadman Plaza East Brooklyn, New York 11201
COPIES OF ALL DOCUMENTS MUST BE SENT TO:_________________
Clerk of the Panel Judicial Panel -on Multidistrict
Litigation 1120 Vermont Avenue, N.W. Suite 1002 Washington, D.C. 20005
FOR PLAINTIFFS
Victor J. Yannacone, Jr. Yannacone & Yannacone Post Office Drawer #109 Patchogue, New York 11772
Stephen J. Schlegel Schlegel & Trafelet, Ltd. One North LaSalle Street Suite 3900 Chicago, Illinois 60602
Benton Musselwhite Law Offices of Benton Musselwh
Inc. Suite 517 609 Fannin Houston, Texas 77002
Thomas Henderson Henderson & Goldberg 1612 Frick Building Pittsburgh, PA 15219
David J. Dean, Esq. Dean, Falanga & Rose
1 Old Country Road Carle Place, New York
11514
Agent Orange Plaintiffs'
Management Committee
^ JL26 Court Street, Suite 304-8
Brooklyn, N.Y. 1 1 2 ^
UNI T E D STATES D I S T R I C T COURT EASTERN D I S T R I C T OF NEW YORK
In re
UAGENT ORANGE"
Product L i a b il i t y L itig a tio n
M
fyc- . ' 1 . inD '* ^ Jr
x
MDL 381 (A ll Cases)
x
P L A I N T I F F S ' I N I T I A L L I S T OF FACT . WI TNESSES I N SUPPORT OF CLAI MS
? -m
MARCH 1 5 ,
1'z"}J-/0..-;>;.-r Ua 0 oca
P0 3-T
P L A I N T I F F S ' MANAGEMENT COMMI TTEE 26 C o u r t S t r e e t B r o o k l y n , NY 1 1 2 4 2 (212) 330 - 0900
P L A I N T I F F S ' I N I T I A L L I S T OF FACT WI TNESSES I N SUPPORT OF CLAI MS
P l a i n t i f f s submit the follow ing l i s t of p o te n tia l
w itn e s s e s to be c a l l e d a t t r i a l p u r s u a n t to th e S c h e d u lin g Order
For the Completion ofDiscovery
dated January 10,
1984.
P l a i n t i f f s reserve the r i g h t to c a l l any of the below l i s t e d
i n d i v i d u a l s as a w i t n e s s a t t r i a l .
- ' ' i L i o n , r 1 r ui c !
\ m: by
' t o 1 i.:\ 1 "
. > "to ^ r ' g r a p h N o . 7 o f t h e
M a g is t r a t e 's P r e t r i a l Order No. 1 which ' l i s t s witnesses
p l a i n t i f f s wish to depose.
To th e e x t e n t the d e p o s i t i o n s o f
those in dividuals e l i c i t relevant inform ation, p l a i n t i f f s reserve
the r i g h t to supplem ent t h i s l i s t and to c a l l such w i t n e s s e s a t
t r i a l as w e l l . To th e e x t e n t
t h o s e named i n d i v i d u a l s a r e n o t
produced f o r d e p o s i t i o n b u t a r e i n t e r v i e w e d by p l a i n t i f f s , and to
the f u r t h e r extent; th a t i t appears any of them can g iv e r e le v a n t
f a c t u a l te s tim o n y , p l a i n t i f f s re s e rv e the r i g h t to c a l l them a t
t r i a l as w e l l .
P l a i n t i f f s w i ll supplement this l i s t promptly
upon the r e c e i p t o f i n f o r m a t i o n te n d in g to i n d i c a t e t h a t such
a d d i t i o n a l w i t n e s s e s m ight be c a l l e d a t t r i a l .
Since there are at le a s t portions of the testimony of m o s t o f t h e w i t n e s s e s who h a v e b e e n p r e v i o u s l y d e p o s e d , m o s t o f whom h a v e b e e n named b y t h e d e f e n d a n t s on t h e i r p r e l i m i n a r y l i s t s of fa c t witnesses, p l a i n t i f f s reserve the rig h t to e ith e r c a ll each of those w itnesses or to present excerp ts from the testimony o f e a c h . We s u g g e s t t h a t t h e o r g a n i z a t i o n o f t h a t t e s t i m o n y a nd the o b v ious need to reduce the amount o f those r e f e r e n c e s w i l l be done in connection w ith the p r e p a r a t io n o f the p a r t i e s ' p r e t r i a l memoranda and o r d e r s . The r e s e r v a t i o n o f such r i g h t s i s t h e r e f o r e not p r e ju d ic i a l to any p a rty at th is tim e.
Pursuant to the C o u r t ' s i n s t r u c t i o n s and p e r m is s io n ,
13723
i
a d d r e s s e s h a v e n o t b e e n g i v e n f o r some o f t h e w i t n e s s e s named
b e l o w who h a v e b e e n d e p o s e d .
Attached for the C o u rt's
c o n v e n ie n c e i s a l i s t i n g p re p a re d by Wager & S p i n e l l i , c o u r t
r e p o r t e r s , o f a l l w itn e s s e s deposed between June 29, 1982 and
F e b r u a r y 7 , 198 4 . As t o t h o s e w i t n e s s e s who h a v e n o t be e n
d e p o s e d a nd a s t o whom no a d d r e s s i s l i s t e d , p l a i n t i f f s a r e
e n d e a v o rin g on a p r i o r i t y b a s i s to l o c a t e the a c c u r a t e a d d r e s s e s ,
and t h i s l i s t w i l l be s u p p l e m e n t e d t o i n c l u d e t h a t i n f o r m a t i o n on
an "as r e c e i v e d " b a s i s .
The a d d i t i o n a l w itn e ss e s not covered by the above r e s e r v a t i o n s , a r e , as f o l l o w s :
DR. THOMAS ABOUD Toledo C lin ic To le d o , Ohio
EDWARD E ADAMS
GORDON A. ANDERSON 102 H ic k o ry Lane Naugatuck, Connecticut
IRENE ANTONIK 812 Sussex A u s t i n , TX 78745
EUGENE BAK
DONALD K. BALLMAN 7722 R evelle Drive La J o l l a , C a l i f o r n i a
DONALD BARNES
E. D. BAUMGARTNER
R. E. BAYNARD
JEANNI.E BEAVERS Flower Hospital Personnel Department S y la w ia , Ohio
B I L L I E MARIE BELL 4404 Bonnie D rive F t . W o r t h , TX 76116
C a r d io lo g is t fo r Mrs. Ford Treated Danny Ford for hypertension.
Texas D i s a b i l i t y O ffic e r and f r i e n d o f J o r d a n s '
Knows t h e h o s p i t a l and business s tra in re Danny Ford
Danny J o rd a n 's mother
13
2
CLOYC.I G. BELL 4404 Bonnie D rive F t . W o r t h , TX 75116
BELL TELEPHONE OF PA 1 P a r k Way P h ila d e lp h ia , Pa. 19101 W. B . BELLS ETCYL H. BLAIR JOHN BLI SH
A . A. BLOCK KANSAS C I T Y , MO. WI L L I A M BLUMENAUER
JOSEPH L . BOLTON
JACK BORRER 12920 Wellswood T r a i l C h e s t e r f i e l d , Ohio 44025 AL BOTHWELL
JAMES E. BOWERS S T . L O U I S , MO. DAN I E L BRAXTON
BOB BROWN
BROWN, SGT
DAVE BUNIN
JOHN S. BUSH, J r .
WI LLI AM CALLAHAN West V i r g i n i a MELVIN CALVIN 2 6 8 3 Bue na V i s t a Way Berkeley, C alifornia
Denny J o r d a n ' s S te p Father Personnel records of George Ewalt
High School frie n d of L a m b i o t t e ' s who was w i t h him in V ietnam
George E w a l t 's Foreman 1975 Served w ith Dan. Jordan in Vietnam With Danny Ford in sprayed areas Economi s t
Was w i t h E w a l t i n V i e t n a m F o r m e r member o f PSAC and d i r e c t o r o f Dow Chemical re government knowledge vs. Dow's knowledge and f a i l u r e to warn.
3
RICHARD CASEY E L L I S CASH EDWARD LEE CHAMDLER EDWARD E. CHAPMAN 5743 N. E uclid Gladstone, Missouri J . G. CHARLTON R08SRT L. CHONOLES 23 C a r m e l l a D r i v e E d i s o n , New J e r s e y EMIL CHRISTOFANQ GEORGE F . COL L I NS
J . G. COPELAND, J r .
DIANE COURTNEY
GEORGE & MARGE CRAWFAS 40 Hock R d . Kennessaw, Ga. JOHN CRAWFAS Beach V a l l e y Rd. A tla n ta , Georgia OWEN & BETTY CRAWFI S 51-33 W hiteford Center Rd. Toledo , Ohio ROBERT CROCKER
EUGENE D. CR I T T E N D E N , J r .
Re H e r c u l e s ' l i a b i l i t y
D irector of procurement Production, Richmond, Va. (P r o c u r e m e n t, s u p p ly and f a i l u r e to warn issues)
A sst. Gen. Manager, '34 Gen. Mgr. S y n th e tic s , 5 5 - 7 2 (Re H e r c u l e s )
Government expert w i t n e s s on c a u s a t i o n
Saw c h an g es i n Danny Ford C h r i s ' s B r o t h e r and S i s t e r
i n Law
Chris' Brother
Mother and dad of C h r i s . Used to t a k e Danny f o r
treatm ent (5133?)
Amounts - doing away herbs - has tapes to determine exposure to Veterans I I ' s
of
D ir. Sales, 55-57 Asst. Gen. Mgr. S y n th e tic s 57-53 953 DuPont Road W ilm ington, D e l . 19307
ROBERT CROCKER
WARREN CRUMMETT 803 C re sc e nt D riv e Midland, Michigan
GEME CUMMI NGS
BILL CURTIS c / o CBS News 5 2-1 W e s t 5 7 t h New Y o r k , New
Street York 10019
THOMAS P. DALBY S. S. DANIELS L. L. DANIELSON
EDWARD DEBOLT D IA Z , STAFF SGT. CHARLES DI LLEY KANSAS C I T Y , MO. LINDA DIMOLA CHARLES DISHNER M DOJNY
OWEN DOLI M 5 225 Sun Va 1 1 ey D r i v e C h a r le s to n , West V i r g in a LAWRENCE E. D0TS0N WILLIAM DUFFIELD CHARLES L . DUNN
JOSEPH DUQUETTE
Dow s c i e n t i s t ; e v i d e n c e c o n c e r n i n g Dow l i a b i l i t y issues. Served with Jordan in Vietnam Evidence concerning eyewitness observations as to the c o n d i t i o n of the country of Vietnam, extent of r e s i d u a l d e f o l i a t i o n and possible photographic exhibits; investigation continues.
U . S . D . A . L i a s o n NACA
With Ewalt in Vietnam
Kerry Ryan's B abysitter
C h a i r m a n , NACA; e v i d e n c e re l i a b i l i t y issues a f f e c t i n g many d e f e n d a n t s in a d d itio n to H ercu les. On S u f f o l k C o u n t y P o l i c e
5
Force with Mike Ryan
J . M. FAGAN
JACK D. EARLY 307.4 L a k e n h e a t h Way Potomac, Maryland 20854
WAYNE EDWARD
PLATOON S G T . ELLY
Was w i t h E w a l t i n s p r a y areas.
DONALD ELMORE
DENNI S ELMOVS
GEORGE W. & EUNI CE EWALT SR. 731 Penn Pines B lv d . C l i f t o n H eig h ts, Pa.
Parents of George Ewalt and f a m i l i a r w i t h family situation
TEN EYCK
WI L L I A M A. FATRCLOUGH
74071 V i a San Fernando Mission V ie jo , C a lifo r n ia 02592
FRED FALANA
With Danny Ford in sprayed areas
WILLIAM F. FALSEY 5705 Lakeview D rive Lake C i t y , Michigan
OT I S E. FANCHER
FARMER, CAPT.
With Danny Ford in sprayed a r eas
L . E . FAST
WI LLI AM FENNER
J . R. FISCHER HERCULES, INC. JACKSONVI LLE, ARK.
B1 8E9T9TY RFaMpAi dYDs A Road Hiram, Ohio
Chris Ford's Business p a r t n e r and good f r i e n d (See Smayda)
THOMAS FORBES Monestary Avenue P h ila d e lp h ia , Pa.
Friend of served in Vi etnam
G e o r g e E w a l t who same a r e a in
13728
JOHN J . FORD 15 W i n t e r b u r y C i r c l e Wilmington, Delaware
KERRY & JEANETTE FORD 5507 Secore Rd.
Lambertvi11e , Michigan
RAY & ROSE FORD
1 3 d78 South County Highway
Ottowa Lake, Mich.
Line
49257
MARGARET FORLAND First Street Ft. Dix, N.J.
JOSEPH W. FOWLER
E( i/ n4 Fj Ra Ai lN)KS
JOHN P. FRAWLEY
H. G. FREDERICKS
VAL K. GAERTNER
JESSE GERSHBERG
E r . D. G l a d n e y E a s t S t . L o u i s , Mo.
A. W. GLEMN
HAROLD G I L L
CHERYL GONDEK 4009 Shawnee T r a i l F t . W o r t h , TX 7 51 3 5
CHARLES E. GRAM TTO
RAYMOND A. G U I D I 420 Essex Place Memphis, Tennessee
B ro th er of Danny Ford
Danny F o rd 's P arents
S is te r of George Ewalt
423d Combat S u p p ly , with Lambiotte in V i etnam Chief toxicologist H e r c u l e s , r e many l i a b i l i t y and causation issues
w ith Ewalt in Vietnam
Dow a n a l y t i c a l c h e m i s t who a l l e g e d l y d e v e l o p e d a n a l y t i c a l method fo r determination of 2 , 3 , 7 , 8 TCDD i n ' 5 4 . Danny J o r d a n 's s i s t e r
COLONEL HAIG WALTER D. HARRI S 199 ALLERTON RD. NAUGATUCK, CONN. E. ROSS HART DAV I D G. HELM 5009 Forest Kansas C i t y , Kansas RICHARD HICKMAN R o u t e 4 , No. .10 Yocum R d . Rogers, Arkansas
JESSE HILSSN PAUL E. HOFFMAN 1202 Lake Shore D riv e North Barrington, Illin o is GRAYDON HOLDEMAN BENJAMI N B. HOLDER 5203 BLOOMFIELD ST. MIDLAND, MICH.
HARRY HOLLAND RAY HOLMES
G. HOLSING DONALD HOLT VERNON HOUCK
F . GERARD K, VADA Ml IK TLL
2 2 0 W. T y l e r Magnum , O k l . 7 3 5 5 4 THOMAS R. HUNT RAPHAEL H. HUSTON
Was w i t h E w a l t i n s p r a y area
Dow g o v e r n m e n t s a l e s Mgr. re Dow's attem pts to s e ll products including herbicides to the government
Dow M e d i c a l D i r e c t o r r e health e ffe c ts in workers, f a i l u r e to warn and la c k o f minimum e f f e c t l e v e l . Friend of Lambiotte's Dow p l a n t s u p e r v i s o r who c o n t r a c t e d chloracne; re health effects
G eo r ge E w a l t ' s Foreman 'SO
Danny J o r d a n 's In-Laws
3
PETER INFANTE
GEORGE JACKSON
JOHN J ENNI NGS Apt. B 12 Lansdowne Avenue Lnnsdowne, Pa.
DAVI D JORDAN
LYNNE KELLER 208 Braeswood A u s t i n , TX 7^704
R. EMMET KELLY 885 SO. SKINNER S T . L O U I S , MO.
VAN A. KELLY P h i la d e l p h ia , Pa.
GEORGE C. KEMPSON 143 South Gore Webster Groves, Missouri
EUGENE E. KEMAGA 1 23 1 N. -Wagner Road E ssexville, Michigan
FRANCIS KENNEDY
W I L L I A M K I DD
CARL & CARLA KIMG 3 3--42 R o m a k e r Toledo, Ohio
J . M . KI RG I S
A. Y. KISTNER KANSAS C I T Y , MO.
FRANK W. KLEMAN S T . L O U I S , MO.
George E w a l t ' s Foreman la t e '70s to e a rly '80s High School fr ie n d of G e o r g e E w a l t who was i n V i e t n a m a t same tim e and knows h i s medical problems.
Friend of Danny J o rd a n 's
Monsanto
With Ewalt in Vietnam
Dow e m p l o y e e r e envi ronmental persistance, to x icity and l i a b i l i t y issues
Closest frie n d s of the (Danny) F o r d s ; she was w i t h C h r i s when t h e y found out t h a t Danny F o r d ' s le g was c a n c e r o u s and how much p a i n he was i n . Addre ss may a l s o be 3320 Romaker Road
o
*
GEORGE KLINE J. KLIMGNAN PHILIP LANDRTGAN
JULES LAM MICHAEL LAMBOTTE
J. K. LEASURE R. R. No. 2 - 3ox 157 Makanda, Illinois FRANK LEMAK
P. R. LITTLE
HAROLD A. LLOY DR. ANNETTE LYNCH School houso Lane Philadelphia, Pa. J. R. MALLET N. MALONEY DAVE MANN
THOMAS MARKWOOD Jeep Corp. 940 N. Coe. Blvd. Toledo , Ohio ROBERT E. MASKILL 41 East 53rd Street Kansas City, Missouri RICHARD J. MARRESE JAMES MASON JOHN MASON 12 Tanners Dean Leatherhead, Surrey Eng land L. G. MAIJREY PAUL MAYFIELD
10
David Lambiotte's Uncle Brother of David Lambiotte
Ewalt's daughter's psycholog ist
Employer of Lambiotte before and after Vietnam Payroll Records and lost
income re Danny Ford T-H Agriculture; liability issues
r{i OO' O
<*
M. McCALLEY
W IL LI AM J. M cC ARV IL LE 12 Ridge Crest JCourt Chesterfield, Missouri
DONALD .McCOLLISTER 5522 Whitehall Street Midland, Michigan
w i l l i a m d . Mc e l r o y 9551 BLACK GOLD RD. CALIFORNIA
JUDY McKINSEY 1899 Rapids Road Hiram, Ohio
SGT. TIMOTHY MEDDOR
COL. BRUCE MEYERS 59 1-1 W. MERCER WAY ST. LOUIS, MO.
ROY MEYERS
CHARLES E. MINARI CK
SHERRY MOSHER 18 4 335 'Winchester R d . Toledo, Ohio
DEBDAS MUKERJEE
Dow
Business partner of Chris Ford and close friend (See McKimnley) served with Jor da n in Vietnam
Business manager kennel. Stress strain on Chris
Address may also Winchester
of the and Ford be 1950
Government expert
BOB NOBER 71 Lempa Road H o .1land , Pa
Was with Ewalt in Vi et nam
WI L L IA M R. NUMMY 711 W. Mea dow br oo k Drive Midland, Michigan
JACKIE OCHS c/o GREEN MOUNTAIN P. 0. BOX 229 TURNER FALLS, M A .
POST
FILMS
Photographic exhibits
& personal observations & investigations
BRIAN O'CONNOR J. F. O' CON NO R
Friend of the Ryans
II
SGT. THOMAS O'DONNELL
DR. OERTNER J. E. PALLARD FRANCIS PANNETON L. A. PARDEE PHIL PENN
REBECCA PEPPER 67.18 Si lvermine Drive 81004 A u s t i n , TX 78776 JACK E. PETERSON 66 4 Forest Grove Circle Brookfield, Wisconsin
F. H. PLACET WILLI AM L. POPHAM DONALD PURDY 160 F re der ic ksb er g Drive Avon Lake, Ohio THOMAS RAFERTY New York City VIRGIL B. ROBINSON 2620 Quail Hill Drive Upper St. Clair, Pa. 15241 V. K. ROWE
ROBERT R. RUMER
Served with Jo r da n in Vietnam
Amounts - doing away . of herbs - has tapes to de termine exposu re to Ve te ran s I I 's Neighbor of Jordan's
Former Dow employee who addressed industry representatives at March, 1965 meeting concerning rabbit ear testing
With .Mike Ryan in Vietnam
Dow's former Chief Toxicologist - liability issues as well as causation questions; Dow's knowledge of extreme toxicity and failure to warn
**
CECIL RUSSELL 45 WINGFIELD ROW GLENDALE, MO. MAUREEN RYAN
MICHAEL RYAN
VICKY RYAN
HFEl oNRr Yi d aSADLER
UMBERTO SAFFIOTTI
DR. SALTER
ED SAWGRASS SUSAN SCANLON Riplen Street Philadelphia, Pa. W I L L I A M R. SCHAMBRA .1411 W. St. Andrews Midland, Michigan
ARTHUR J. S CH L E SS I N G ER OLGA SCHNELL
SCHUBACK LAPIN 0. SCOTT R. B. SCOTT RICHARD SCOTT
SGT. SHARKEYl
l? _
School Principal who knows Kerry's education
Mike Ryan's Father
Kerry's Grandmother
Boyhood friend of Lainbiotte's who was with him in V i etn am
Government causation witness with factual testimony re g o v e rn m en t contract defense, liability issues and issuance of Bionetics Laboratories Report.
Dr. who told Lambiotte to stop working
S is te r of George Ewalt
Dow f o r m e r e m p l o y e e f a i l u r e to warn and business of s e llin g herbicides to the government
re
Neighbor of the Ryans
Drafted with Lambiotte and saw in V i e t n a m
David Lambiotte's
4K
platoon Sergeant in V i etn am
DEX TER B. SHARP 13042 Weatherfield Drive St. Louis, Mo.
A. E . SIDWELL
LARRY SILVERSTEIM
Dow former employee re March, 1955 m eeting s at Dow and other liability issues and health effects to Dow empl oye es
BETTY SMAYDA 1399 Rapids R d . Hayram, Ohio
Business partners - Chris Ford's plus good friend. What Fords went through and personal strains
J. G. SMERALDI
CAPT. SMITH
With Ewalt in spray areas
PLATOON LT SMITH
With Ewalt in spray areas
TOM X. SMITH
ROBERT SNODGRASS Hu nt in g to n, W. V a .
With Danny Ford in Sprayed areas
HOWARD C. SPENCER 11008 Cameo Drive Sun City, Arizona 35351
Developed rabbit ear test in 1941 while a Dow employee
L.P.SEITZ
A. JOHN SPEZIALE 311 N. Umberland Avenue Redwood City, California 94031
JOHN A. STEPHENS 800 N. Lindbergh Blvd. St. Louis, Missouri
FREDERICK G. S T EWA RD 173 Woodland Forest, Section 3 Tuscaloosa, Alabama 35405
CHARLES N. STEWART
MICHAEL STRANGE 521 Bomber Road Ft. Worth Texas
Friend of Danny Jordan 1 3 7 '5
*
FREDERICK STRANSKY
SGT. STRAWBERRY
DEIRDRE STRANSKY
PATRICIAL STRANSKY
JACK STRUM 712 Short Spoon Circle North Carolina JOHN S. SULLIVAN W IN F I E L D W. S UN DER LA ND 5300 Westpath Way B e th escla , Maryland DANIEL W. SWEET MILTON A. TAVES 210 M. Spring Va ll e Road Wilmington, Delaware CLINTON TAYLOR
R. D. THOMPSON WILLIAM THOMPSON 31S GEORGINA AVE. SANTA MONICA, CAL. A. L. TREI SB EC K DAN TWIFF Woodland Street Slyvian, Ohio
DAN TWISS 4910 Woodland Sylvania, Ohio
Mike Ryan's Brother-inLaw Was with Ewalt in spray areas Teacher - knows Kerry Ryan - a sp ecialist in learning disabilities Nurse and Family Counseller for Ryan
family
Business partner of David Lambiotte's
Union commission man at Danny Ford's job. Also a friend of Dan's. Has information about union contract (current) and personnel matters. See also Twiss. Committee man at AMC Jeep See Twiff above
15
W IL LI A M R. UDELL SO TE ALW OO D CREVE COEUR, MO.
EDWIN T. UPTON W. VAMDERVENDOR JANE WARD
3527 M . 151
Temperance, Mich. 43102
ROBERT T. WEB BE R 4 Media Drive St. Louis, Missouri 5 3.14 5
ADAM WENKUS Route 5 - Box 904 Waupaca, Wisconsin
BUTCH WESTERLAND
HARTLEY WILDER S G T . J. WILLIS
MARK G. W I L T S E N . WTR7.
WILBUR WOMLGAMUTH 49-21 Bar ton Place Slyvian, Ohio
L. K. WO OLF OL K JOHN WRIGHT R. WRIGHT R. T. YATES
YORK HOSPITAL MITCHELL ZAVON KETTERING LABS CINCINNATI, 0.
T-H liability issues
Neighbor of Fords
Supply and distribution, defendants' failure to warn; former Defense Military Supply Office employee.
VSeiertvneadm with Jordan in
Served w ith Danny Jordan in Vietnam
Union Stewart at Danny Ford's - knew Dan when he had the cancer and the wages at the time and the chang es in Dan
Former employer of Lambiotte
*
CHARL ES P. ZORSCH
ROUTE 5, BOX 30 PACIFIC, MO.
March 15, 1934
AGENT ORANGE PLAINTIFFS' MANAGEMENT COMMITTEE
By
17
vji i spinelli
certified shorthond reporters
Date Taken June 29, 1982 June 30, 1982 July 1, 1982 July 8, 1982 July 13, 1982 July 15, 1982 July 19, 1982 July 20, 1982 July 21, 1982 July 26, 1982 July 27, 1982 July 27, 1982 July 28, 1982 July 29, 1982 July 30, 1982 August 3, 1982 August 4, 1982 August 16, 1982 August 17, 1982 August 26, 1982 August 27, 1982 September 8, 1982 September 9, 1982 September 15, 1982 September 16, 1982 September 21, 1982 September 22, 1982 September 23, 1982 September 29, 1982 September 30, 1982 October 5; 1982 October 6, 1982 October 14, 1982 October 19, 1982 October 20, 1982 October 21, 1982 November 3, 1982 November 9, 1982 November 10, 1982 November 16, 1982 November 17, 1982 November 18, 1982 November 24, 1982 December 1, 1982 December 2, 1982 October 26, 1982
Page
Witness Bernard J. Jandorf Dr. Van Murray' Sim Bernard J. Jandorf Dr. Marcus M. Key Dr. Robert A. Darrow Donald W. Falconer Dr. Van Murray Sim David Henry Groth Richard R. Bates Kent R. Irish Katherine Diane Courtney Charles E. Minarik Charles E. Minarik Charles E. Minarik Dr. Marcus Key Philip C. Kearney William Upholt Philip C. Kearney William C. Shaw Donald Birmingham Donald Birmingham Robert J. Anderson Warren C . Shaw Walter Edward' Sultan Garnett R. Higginbotham David Firestone John L. Buckley Sigmund R. Eckhaus Andrew W. Anderson Carleton G. Shead Edward A. Metcalf Sigmund R. Eckhaus' David Firestone William B. Ennis, Jr. Joseph D. Avellino Richard G. Horton Frank J. Vocci Lester L. Miller Dr. Benjamin Harris John F. Callahan William W. Dorrell William F. Barthel Keith H. Jacobson Merl Ringenberg James Arthur Hebbeler
William W. Stone Jr.
w a g a an a spinelli
certified shorthand reporters
Date Taken December 7, 1982 December 8, 1982 December 9, 1982 December 9, 1982 December 9, 1982 December 14 , 1982 December 16 , 1982 December 15 , 1982 December 15 , 1982 December 17 , 1982 December 21 , 1982
January 3, 1983 January 5, 1983 January 11, 1983 January 11, 1983 January 12, 1983 January 13, 1983 January 17, 1983 January 18, 1983 January 18, 1983 January 18, 1983 January 18, 1983 January 19, 1983 January 20, 1983 January 20, 1983 January 20, 1983 January 21, 1983 January 24, 1983 January 25, 1983 January 27, 1983 January 27, 1983 February 1, 1983 February 2, 1983 February 3, 1983 February 4, 1983 February 7, 1983 February 8, 1983
Page -2-
Witness
Seymour L. Friess
Robert E. Cox
'
Paul C. Warnke
Theodore C. Byerly
Harry W. Hays
Lawrence Fishbein
Dayton Klingman
Carl Gwin Baker
John S. Foster
Herbert G. Fredericks
Ralph T. Ross
Paul Aaron Possick Henry Fischbach Cyrus Robert Vance John S . Leary Lawrence M. Petrucelli Fred I . Edwards Herbert E. Stokinger Joseph A. DiPaolo Dohrman H. Byers Douglas H.K. Lee Boris J. Osheroff William A. Fenner Garth Fitzhugh Harold Brown Levi T . Burcham Francis Kennedy Thomas A. Treglia Abram Saul Kaplan George M. Lawton . Eugene Bak Nicholas S. Cox Fred J. Delmore Riley D. Housewright John L. Traub Charles E. Granito Edward Lee Chandler
* . / :w a g a a n d spinelli certified shorthand reporters
Date Taken February 8, 1983 February 9, 1983 February 10, 1983 February 10, 1983 February 11, 1983 February 11, 1983 February 14, 1983 February 15, 1983 February 15, 1983 February 16, 1983 February 17, 1983 February 18, 1983 February 22, 1983 February 22, 1983 February 23, 1983 February 23, 1983 February 24, 1983 February 25, 1983 February 25, 1983 March 1, 1983 ( March 1, 1983 March 2, 1983 March 2, 1983 March 3, 1983 March 8, 1983 March 10, 1983 March 10, 1983 March 16, 1983 March 17, 1983 March 17, 1983 March 22, 1983 March 22, 1983 March 23, 1983 March 23, 1983 March 24, 1983 March 25, 1983 March 25, 1983 March 28, 1983 March 31, 1983 April 1, 1983 April 7, 1983 April 7, 1983 April 7, 1983 April 8, 1983 April 8, 1983 April 12, 1983 April 13, 1983 April 14, 1983 March 30, 1983
Page -3-
Witness
Donald Whittam
Anthony Sinclitio
Thomas R. Dashiel
Lester Boyer
*
William J. McCarville
Frank L. Bauer
Charles E. Bushey
William J. Crawford
Walter W. Melvin, Jr.
Robert S. McNamara
John H. Gerety, Jr.
R. Emmet Kelly
John S. Bush, Jr.
Lee A. DuBridge
Robert L. Andreoli
Robert W.'Morthland
James H. Gardner
George M. Lawton
Kennard A. Reynard
Alan P. Poland
Arthur J. Schlesinger
ADrl.a n HePn. ryP oKl ainsdsinger
William Childs Westmoreland
John P . Frawley
Harold H. Gill
Albert E. Hayward
V.K. Rowe .
.Jack E. Burton
Robert A. Shade
Gordon A. Anderson
William H. Summerson
Benjamin Brace Holder
Melvin M. Rabstein
William T. Thompson
Jerome Wilkenfeld
Harold H. Gill
Oscar Garth Fitzhugh
Etcvl H. Blair
Vincent McRae
Edwin T. Upton
Wayland J. Hayes
George M. Lawton
George M. Lawton
Edwin T. Upton
James Henry Wills
?-
Harry Heiman
X3*74.i
Seymour Silver
Donald D. McCollister
w aga and spinelli
certified shorthand reporters
Date Taken April 22, 1983 April 27, 1983 April'. 28, 1983 April 28, 1983 April 29, 1983 April 29, 1983 May 2, 1983 May 2, 1983 May 2, 1983 May 2, 1983 May 3, 1983 May 4, 1983 May 4, 1983 May 5, 1983 June- 6 ,' 1983 June 3, 1983 June 6, 1983 June 13, 1983 June 14 , 198 3 June 21, 1983 June 23, 1983 June 24, 1983 June--28, 1983 June 29, 1983 June 29, 1983 July 1, 1983 July 6, 1983 July 6, 1983 July 11, 1983 July 11, 1983 July 11, 1983 July 12, 1983 July 13, 1983 July 14 , 1983 July 14, 1983 July 15, 1983 July 18, 1983 July 21, 1983 August 1, 1983 August 3, 1983 August 3, 1983 August 4, 1983 August 5, 1983 August 9, 1983 August 10, 1983 August 11, 1983 August 12, 1983
P a g e -4
Witness Gordon J. MacDonald General Maxwell Taylor Donald F . Hornig Charles L. Dunn Ronald Joseph Kassel Spurgeon M. Keeney, Jr. Kenneth M. Endicott John C. Atkinson William Horwitz Cecil' H. Russell Charles P. Zorsch William R. Udell Umberto Saffiotti Nathan Gordon Gordon J. McDonald Steve S. Szabo Albert C. Kolbye Warren R. Bontoyan John C. Atkinson Milton K. Christensen Dr. Michael Klein Marshall Stubbs Robert M. Gastineau E. Ross Hart Harold N. McFarland Ian Alastair Mitchell Dr. Douglas Lindsey Daniel W. Sweet Herschel E. Griffin William F. Barthel K. Diane Courtney Harold J. Magnuson William D. McElroy General James A. Hebbeler Joseph F. Coates Peter S. Bing William M. Creasy John F. O'Leary Graydon C. Essman,III Walter Leo Zielinski, Jr. Herbert F. York John D. Baldeschwieler George M. Lawton Roswell Daniels Umberto Saffiotti Robert J. Heaston Robert H. DuGuid
cwertifaiedg.shaorthaandnredportesrsp in e lli
Date Taken August 15, 1983 August 15, 1983 August 16, 1983 August 17, 1983 August 17, 1983 August 17, 1983 August 17, 1983 August 18, 1983 August 19, 1983 August 19, 1983 August 22, 1983 August 22, 1983 August 23, 1983 August 24, 1983 August 24,1983 August 25, 1983 August 25, 1983 August 30, 1983 August 30, 1983 August 30, 1983 August 31, 1983 August 31, 1983 September 7, 1983 September 8, 1983 September 12, 1983 September 13, 1983 September 14, 1983 September 15, 1983 September 16, 1983 September 16, 1983 September 16, 1983 October 3, 1983 October 3, 1983 October 4, 1983 October 4, 1983 October 6, 1983 October 17, 1983 October 17, 1983 October 17, 1983 October 19, 1983 October 19, 1983 October 20, 1983 October 20, 1983 October 21, 1983 October 21, 1983
^
Page -5-
Witness David M. Cawthorne George W. Connell Marshall Steinberg, John L. Buckley Charles E. Stewart J.G. Smeraldi Wayne Edward John T. Weimer Henry L. Verhulst Dorothy M. Ward Dr. Arthur H. McCreesh Paul D. Harkins Dr. Richard D. Horton Normand E. Olivier Jane Lewi's Frank J. Vocci Verne C '. Fryklund, Jr. Dr. Thomas C. Simmons Henry N. Doyle Eberhardt Recht'in Laverne A. Parks Brunildo Antoio Herrero Paul Doty Frank H. Westheimer Louis B. Arnoldi John Angel David Jordan .Donald W. Norberg William T. Thompson Filiberto Vargas Warren Crummett John Wilder Tukey Willis Hart Donald W. Fuhlage Francis Gene Douglas Jerome D. Wiesner John A. Stephens Jack E. Peterson Robert L. Chonoles Frederick G. Steward Virgil B. Robinson William G. Kratz Dexter B. Sharp Jack A. Borror Dr. Howard C. Spencer
CERTIFICATE OF SERVICE
The undersigned, Edward F. Hayes, III, does here by ce rtify that on the 15th day of March, he did serve the enclosed document on all those shown on the attached service list by private messenger service with the following exceptions; Chambers copies were de livered p e rs o n a l l y by hand to Judge W e i n s t e i n and Magistrate Scheindlin, before the hour
Rivkin, Leff, Sherman & Radler At torneys for Dow Chemical Co. 100 Garden City Plaza Garden City, NY 11530
Townley & Updike Attorneys for Monsanto 405 Lexington Avenue New York, NY 10017
Co.
Cadwalader, Wickersham & Taft Attorneys for Diamond Shamrock One Wall Street Mew York, NY 10005
Arthur, Dry & Kalish Attorneys for Uniroyal, Inc. 1230 Avenue of the Americas New York, NY 10020
Shea & Gould Att or ney s for Uniroyal, 330 Madison Avenue Mew York, NY 10017
Inc.
Clark, Gagliardi & Miller Atto rn eys for T&H Agriculture 99 C ourt Street White Plains, NY 10501
Budd, Larner, Kent, Gross,
Pi cillio Sc R ose nthal
Attorneys for Thompson Chemical
3? - ::
' , - V -
!7
. ,i. '1 ' * ; I v i
I". ' Room 9 0 4D
r'-.ment of Justi ce
Safeway Building
Washington, DC 25030
Kelley, Drye & Warren Attorneys for Hercules, 101 Park Avenue New York, NY 10173
Inc.
UNITED STATES DISTRICT COURT
E--A--S---T--E--R--N----D--I--S--T--R--I--C---T----O--F----N--E--W----Y---O--R--K----------- X
In re: "AGENT ORANGE"
Product Liability Litigation -------------------------------- X
SUPPLEMENT TO PLAINTIFFS' EXPERT WITNESSES' EXPANDED SUMMARIES IN ACCORDANCE WITH F.R.C.P. 26(b) (4) (A) (i) AND IN ACCORDANCE WITH MAGISTRATE'S
RULINGS OF FEBRUARY 29, 1984_____
PLAINTIFFS' MANAGEMENT COMMITTEE
By/' Ar
U J fU s K jJ U U
Thomas W. Henderson, Esquire Alison Pettiette, Esquire
A jew of ihesofondS
hie iSlijktlij biujid f[kis oddj the Cofid/hon o f -phe cLoccLmend <t n d dhc Copy machjne.
Pfhank to*!
ms
DEBORAH A. BARSOTTI, Ph.D.
V. GROUNDS FOR EACH OPINION A. General Dr. Barsotti will rely upon her review of medical and scientific
literature which is cited in her Curriculum Vitae and References previously submitted. In addition, Dr. Barsotti's educational and personal experience are set forth in her Curriculum Vitae.
Dr. Barsotti became involved in research with the Halogenated Aromatic Hydrocarbons (HAH's) in 1973 as a graduate student at the University of Wisconsin. After the completion of her Ph.D. in 1980, Dr. Barsotti continued with the projects at the University of Wisconsin until her leaving to accept a position of Assistant Professor in Toxicology at the Philadelphia College of Pharmacy and Science.
During her tenure at the University of Wisconsin, she was involved with (1) preparation of experimental protocols; (2) the establishment of the clinical and reproductive test parameters; (3) the day to day operation of the Resus monkey colony including sample acquisition and testing, animal husbandry and autopsy procedures and data analyses of Resus monkeys chronically exposed to HAH's as well as their control. This work has culminated in numerous publications as presented in Dr. Barsotti's Curriculum Vitae. In addition, she has been invited to speak or present her work in various atmospheres including community meetings and scientific symposia. The specific chemical toxic compounds that she has worked with are polychlorinated biphenyls (Aroclors 1248 and 1016 products), the polybrominated biphenyls (Fire Master product), and hexa and tetrachlorinated dibenzo-para
dioxins (HCDD's and TCDD's). Since Dr. Barsotti's acceptance at her new position in January
of 1983, she has continued to analyze the data from the studies of Wisconsin for publication purposes. In addition, Dr. Barsotti has biological samples from these studies which are to undergo further analyses. Furthermore, Dr. Barsotti has submitted a National Institute of Health (NIH) graph application to continue research on HAH's.
B. Specific In addition to all references previously listed in Dr. Barsotti's References and Curriculum Vitae, the following references regarding dioxins and toxins, particularly TCDD, support Dr. Barsotti's Opinion IV A: a) Poland and Knutson,1982. b) Allen, et al. 1977. c) Allen, et al. 1979.
B. 4. The statement "Recent advances in detection methodology" is hereby deleted. Additional specific references in support of Opinion IV D include the following:
a) Nature, Vol. 283, p. 772, 1979.
B. 6. With respect to Opinion IV F, the underlying premise of animal toxicity testing is that the effects produced by the compound in laboratory animals are applicable to man:
a) Casarette and Doull's Text Book: Toxicology, The Basic Science of Poisons, 1980.
b) Principles of Animal Extrapolation, Edward J. Calabresi, University of Public Health, Amhurst, Mass. 1983, published John Wiley & Sons.
In the case of HAH's, including TCDD, similarities exist in the clinical and reproductive symptoms observed in Resus monkeys and that reported in man:
a) Barsotti, et al. 1976. b) Barsotti, 1980. c) Schanz, et al. 1970. d) Kuratsune, et al. 1972. e) Koshimura, 1974. f) EPA, 1979. g) Bogen, 1979.
In addition, symptoms in both species appear to be latent or persistent after TCDD exposure has ceased:
a) Barsotti personal research. b) Oliver, 1975. c) Pazberoba, et al. 1981.
References:
J.R. Allen, J.P. Van Miller and D.A. Barsotti, Toxicol. Appl. Pharmacol., 47, 179, 1979. G. Bogen, J. Amer. Ed. Assoc., 242, 2391, 1979. EPA Report, p. 78, February 28, 1979. Kuratsune, M . , Yoshimura, T., Matsudaka, J., Yamaguchi, A., Environ. Health Perspec., 1, 119, 1972. Nature, Vol. 282, p. 772, 1979. R.M. Oliver, Brit. J. Indust. Med., 32, 49, 1975. Yoshimura, T., Fukuoka, Acta Medica, 65, 74, 1974.
1 3 7 5rr>un
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ARTHUR W. GALSTON, Ph.D.
II. SUMMARY OF TESTIMONY
Dr. Galston personally observed the devastation of the Vietnamese countryside on four separate occasions between 1971 and 1982 and will describe those observations by way of pictorial evidence he has available to him, including his own slides of the defoliation of the countryside of Vietnam. More specifically, Dr. Galston visited South Vietnam during the year 1975 for approximately two weeks. He later visited South Vietnam to attend the Ho Chi Minh Symposium in 1983, which lasted one week. However, Dr. Galston remained in Vietnam for an additional week and made several visits to the Ma Da Forest as well as the surrounding countryside in order to evaluate the permanent defoliation and destruction of the Vietnamese countryside more than ten years after the war in Vietnam had ended. In addition, Dr. Galston will discuss the manufacturing processes of 2,4,5-T and 2,4-D and the necessity of developing further refinements on the processes used by industry in order to significantly reduce the imminent dangers to our society from exposure to dioxins and if these manufacturing processes cannot be so refined to eliminate the manufacturing of these chemicals.V.
V. GROUNDS FOR EACH OPINION A. General The bases f o r th e f a c t s and o p in io n s to which D r. G a ls to n w i l l
t e s t i f y in c lu d e a re v ie w o f the a p p lic a b le m e d ic a l and s c i e n t i f i c l i t e r a t u r e which is a tta c h e d to the Expanded Summary (R e fe re n c e s ) p re v io u s ly su b m itted
to the Court, as well as all articles and publications cited in Dr.
Galston's Curriculum Vitae which has been previously submitted to the
Court and which will be supplemented below as to any citations then "in
press" (relating to IV (1), (2), (3), (4) and (5)); his educational
and professional background specifically include his work experience
at E.I. Dupont de Nemours, with the individual manufacturing processes,
and forty years of experience with plant growth substances. See
Curriculum Vitae and publications previously attached to Expanded Summary
for experience and educational background. In support of Dr. Galston's
Opinions IV (1), (2), (3), (4) and (5) in addition to all references
previously listed in Dr. Galston's References and Curriculum Vitae, Dr.
Galston specifically makes reference to the following citations in
support of his five specific opinions:
a) Baughman, R. & M. Meselson, 1973.
b) Isensee, et al. 1971.
c) Kearney, et al. 1972.
d) Lang, A. ed. 1974.
e) Leng, M.L., 1972.
f) Meselson, M . , et al. 1978 (Arlington, VA)
g) Meselson, M . , et al. 1972.
h) Mrak, 1969.
i) Shadoff, et al. 1979.
j) Tung, T.T., et al. 1973.
k) Westing, A.H., 1973.
l) Whiteside, T., 1977.
m) Galston, Green Wisdom, Basic Books, Inc., 1981.
n) Galston, 1980. Herbicides in Academic American Encyclopedia, Arete Publishing Co., Inc., Princeton, NJ.
_ ^ r.^
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o) Galston, 1979; Herbicides: A Mixed Blessing, BioScience 29: 85-90.
p) Galston, 1979, Plant, People, Politics; BioScience 20-7: 405-410 illus.
q) Ho Chi Minh Symposium: submitted article which is being sent and will be produced for the defendants.
In addition, Dr. Galston will rely upon his work in connection with the Ho Chi Minh Symposium (which work, while currently in press, will be provided to the defendants, at least the contributions of Dr. Galston which he has recently obtained to "proof") ; his knowledge as to TCDD transmission to humans through the food chain by his review of significant scientific and medical literature (additional references and articles are attached and incorporated 'by reference to the Expanded Summary and listed under IV entitled "Substance of Opinion".) Further, references attached to the previously submitted Summary are reurged at this time, as well as all articles, publications, and presentations of Dr. Galston which are listed in Dr. Galston's Curriculum Vitae.
B. S p e c ific In a d d itio n to the general substance of opinions lis te d under IV , Dr. Galston's research has involved the studies of chemical and physical plant growth regulatory systems. These include (a) auxins (related to herbicidal compounds); (b) gibberellins; and (c) polyamines. Physical factors included in his research include (a) red light (perceived by phytocromes); (b) blue light (perceived by flavoproteins). He has also studied growth and differentiation in tissue cultures including regeneration from single cells and protoplasts. In his auxin research (related to herbicides), more specifically Dr. Galston has studied the compounds and 2,4,5-T and related phenols and their effect on the activity of plant
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LENNART HARDELL, M.D., Ph.D.
Dr. H ardell's personal experience is set forth in "I. Q u a lific a tio n s ". He has seen and trea ted numerous cancer p a tie n ts , and in p a rticu la r, has seen and treated approxim ately 10-15 cases of so ft tissu e sarcoma per year sin ce 1976.
Dr. Hardell has completed one additional epidem iological study which in v estig a tes the rela tio n sh ip of phenoxy h erb icid es and liv e r cancer. Dr. Hardell w ill forward th is im m ediately.^
Dr. H ardell w ill forward the medical records ^ of the basal c e l l carcinoma p a tie n t referred to in h is Summary, i f perm itted to do so under Swedish law.
Dr. H ardell w ill forward the copies of the underlying data ^ which formed the b a iss of h is various ep id em iological stu d ie s.
1 / Copies w ill be supplied to counsel upon re c e ip t.
MAUREEN C. HATCH, Ph.D.
I I . SUBJECT MATTER
Pursuant to order of M agistrate Scheindlin , Dr. Hatch w ill te s tify at length to the data co llected in Vietnam regarding untoward pregnancy outcom es. The data c o lle c te d in Vietnam were provided to Dr. Hatch for her review a t the Ho Chi Minh C ity Symposium. She w ill provid e th e u n d erlyin g Vietnam ese stu d ies which are cu rren tly u n a v a ila b le to the d efen d an ts, and th is w ill be incorporated herein and attached to th is Supplement for a ll purposes.
V. GROUNDS FOR EACH OPINION A. General Dr. H atch's review of a p p lica b le m edical and s c ie n t if ic lite r a tu r e
has been attach ed and in corp orated to Dr. H atch 's Expanded Summary and i t e n t a ils a l l of Dr. H atch's own a r t ic le s which are c ite d in her curriculum v ita e previously submitted, as w ell as applicable sc ie n tific m edical lite r a tu r e by others which is lik ew ise included in Dr. H atch's curriculum v ita e; attendance and/or p articip ation at various seminars (please see the curriculum v ita e which was p reviou sly subm itted w ith Dr. H atch's summary, these include her attendance and/or p articip ation at various seminars including her presentations of papers). Dr. Hatch has attached copies of her various presentations at conferences to the Supplement. Although these papers were not published, Dr. Hatch presented these papers at the various sem inars lis t e d in the Addendum and curriculum v it a e p r e v io u sly su b m itted .
Dr. Hatch w ill r e ly on a l l o f h er p u b lish ed and nonpublished a r t ic le s and presentations.
B. S p e c ific 1. Dr. Hatch has attached a copy of Dr. John C on stab le's and Dr. Maureen H atch's a r tic le which is referred to and which w ill be relie d upon sp e c ific a lly by Dr. Hatch as to th is opinion. In ad d ition , Dr. Hatch has attached the data presented by the Vietnamese in v estig a to rs and reviewed by Dr. Hatch a t the Ho Chi Minh Symposium in 1983.
2 (2 ). As to the opinion and the fa ctu a l b a sis for the opinion as l i s t e d in IV ( b ) , Dr. Hptch has l i s t e d s p e c if ic a lly the a r t ic le s which she w ill use to te s tify as to the opinion s. Dr. Hatch has requested the a r tic le from Peterson which she heard Dr. Peterson present at a s c ie n tific con feren ce. However, h is m anuscript is not prepared at th is time and she w ill supplement th is answer with a copy of the manuscript which she has already requested from Dr. P eterson w ith in two w eeks.
References Cited As far as the referen ces c ite d , a ll a r tic le s which are in press, in c lu d in g the one from C o n sta b le, J . and M. H atch, e d ite d by W estin g, is attached to th is supplem ental summary. As p reviou sly d iscu ssed , the referen ce to R. P eterson , Hormonal changes and "wasting" observed in m oderately-high-dose animal experim ents, presented at the Symposium on Public Health Risks of the D ioxins, R ockefeller U niversity, October 19-20, 1983, th is m anuscript is being obtained from Dr. P eterson and w ill be forwarded to a ll p a r tie s w ith in the next two w eeks. At th is tim e Dr. Hatch does not have a copy of th is a r tic le but has merely heard the presentation.
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Curriculum Vitae
Dr. Hatch w ill rely on a ll of her a r tic le s which she has lis te d in her curriculum v ita e , both published and nonpublished, and she has attached for a ll p a r tie s' convenience a copy of p resentations which have been reduced to w ritin g which she presented at various s c ie n tific conferences and sem inars. In a d d itio n , Dr. Hatch w ill rely on one or more of her a r tic le s which are c ite d in her Addendum and her curriculum v ita e for the purposes o f her tr ia l testim ony.
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ALASTAIR W.M. HAY, Ph.D.
V. GROUNDS FOR EACH OPINION
A. General Dr. Hay l i s t s as a g en era l ground fo r h is op in io n atten d an ce and p a rticip a tio n in various symposia and s c ie n t if ic workshops which are lis t e d s p e c if ic a lly in h is curriculum v it a e a tta ch ed to h is Expanded Summary and s p e c if ic a lly which l i s t s the Ho Chi Minh Symposium he atten d ed in Vietnam in 1983, and the D ioxin Conference he attended in C in cin n a ti, Ohio in August and September of 1983 sponsored by the American Chemical S o ciety , which proceedings w ill be summarized in an a r tic le to be published by the American Chemical S ociety and which a r tic le is being sen t from England and w ill be attach ed as a supplem ent to th is Summary. Review o f va rio u s documents o f c e r ta in d efen d a n ts, which documents were review ed by Dr. Hay in the preparation and w ritin g of The Chemical Scythe and are included and documented in h is bibliography to that book, published by Plenum P ress in 1982. In a d d itio n , Dr. Hay has been provid ed documents from the v a rio u s defendants which the defendants have produced fo r the p la in t if f s and which Dr. Hay w ill use and review p rio r to g iv in g h is d e p o sitio n in th is ca se; p erso n a l research - Dr. Hay has had e ig h t y ea rs o f p erso n a l resea rch on 2 ,4 ,5 -T , 2,4-D and th e ir contam inant, d io x in s . He has p e r so n a lly made two f ie ld tr ip s to Seveso, I ta ly ; two f ie ld tr ip s to Vietnam, in clu d in g h is atten d an ce a t the Ho Chi Minh Symposium, and an a d d itio n a l tr ip to ob serve the lon g-term e f f e c t s of d e fo lia tio n in V ietnam . He has a ls o p e r so n a lly researched h is book, The Chemical S cyth e, and he has further p a rticip a ted in s c ie n tific stu d ies in Great B ritain on the m utagenicity of d ioxin and 2 ,4 ,5 -T as w ell as other chem ical herbicides in conjunction with the In terio r Chemical
Indu stry (IC I) Company in Great B r ita in . With th e ir p erm issio n , he has published h is fin d in g s and th ese are published in Chapter 2 e n title d "Toxicology" of The Chemical Scythe, Lessons of 2,4,5-T and D ioxin , by A la s ta ir Hay, p u b lish ed by Plenum P ress in 1982, New York. More d e ta ile d chem ical stu d ie s which Dr. Hay has p a r tic ip a te d in w ill be pu b lish ed in an a r tic le produced by the American Chemical S ociety from a conference which was held in August-September of 1983, Proceeding Conferences on D ioxin. A copy o f Dr. H ay's own a r t ic le i s c u rren tly in p ress and i s b ein g forwarded to p la in tiffs to be d istrib u ted to a ll p a rties in in terest as a supplement to th is Summary a t th is tim e.
In ad d ition , Dr. Hay's curriculum v ita e lis t s h is education background and exp erien ce, which form the bases of h is fa c ts and o p in ion s. He has in a d d itio n review ed the cu rren t s c i e n t i f i c and m ed ical lit e r a t u r e which has been c ite d s p e c ific a lly in the bibliography attached to The Chemical Scythe. The Chemical Scythe w ill be r elied upon by Dr. Hay, as w ill the a r tic le s and p u b lication s in Dr. Hay' s curriculum v ita e attached to the Expanded Summary p r e v io u sly f ile d .
B. S p ecific Dr. Hay w ill t e s t if y to the grounds which support the above in clu d in g h is knowledge of the spraying of Agent Orange, e sp ecia lly it s e ffe c t on the Vietnamese countryside which knowledge he has obtained by ca refu lly review ing the American A ssociation for Advancement of Science stu d ies conducted by P rofessor Matthew M eselson in 1970, and the N ational Academy of Science report conducted by the Department of D efense in 1974 and a review of the p ertin en t s c ie n t if ic and m edical lite r a tu r e d escrib in g the spraying a c t iv it ie s of Agent Orange in Vietnam which bibliography i s lis te d and c ite d in The Chemical S c y th e , su p ra, and fu rth er h is own p u b lic a tio n s as a tta ch ed to the curriculum v ita e previously subm itted.
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In a d d itio n , Dr. H ay's own p erso n a l ob serv a tio n o f th e V ietnam ese countryside on h is two trip s to Vietnam for that sp e c ific purpose and h is atten d an ce a t th e Ho Chi Minh Symposium in 1983; the purpose and the h isto r ic a l tracing of the animal stu d ies by Dr. Hay's review of the m edical and s c ie n t if ic lite r a tu r e on animal stu d ie s are d eta iled in Dr. Hay's book, The Chemical S cythe; Dr. Hay's review of p ertin en t s c ie n t if ic and m edical lite r a tu r e for h is research in preparation of that book, and a lso review o f the m edical and s c i e n t i f i c lit e r a t u r e , in clu d in g the new Ranch Hand Study r e c e n tly r e le a se d by the U .S. A ir F orce, which has been su p p lied to Dr. Hay by th e p la in t if f s ; h is t o r ic a l tr a c in g o f the human data in clu d in g the in d u s tr ia l a c c id e n ts sin c e 1974, Hay, A. The Chemical S cy th e, Plenum, New York, pp. 9 5-146. A ll r e fe re n ce s to s p e c if ic documents in clu d in g the EPA D ioxin document which has been supplied to the defendants in response to the gu id elin es provided for the p la in tiffs ' government causation and in preparation for the depositions of the p la in tiffs ' government causation w itn esses and the exact t i t l e s of those four documents are as fo llo w s:
1. EPA, R esearch and D evelopm ent, H ealth A ssessm ent Document on D ioxin for the O ffices of Air Q uality, Planning and Standards, prepared by the Environmental C riteria and Assessm ent O ffic e , C in cin n a ti, Ohio 45248 (July, 1983).-
2. EPA, R esearch and D evelopm ent, H ealth and Environm ental ERp -efdfspeiocoxtnsisn,e,sP, brfyoofrtihleetheEfonrOv:ifrfoTinceemtreaon,ftaPSl eoCnlitdraitWaenradisatHe aenaxdnadcAhEslsmoeresorsdgmeibnenceynt zoO ffice, C in cin n ati, Ohio 45248 (June, 1983).
3. ECPrAi,teRr ieaseaforcrh 2a,n3d, 7D,8e-TveClDopDm, epnrte, pAarmedbiefnot r WOatfefric eQ uoafliWtyater R egulations and Standards, by the Environmental C riteria and Assessm ent O ffic e , C in cin n a ti, Ohio 45248 (J u ly , 1983).
4 . EEPnAv,irRonemseeanrtcahl RanedseDarecvhel,opCminenc itn, nDaitoi,x inO,hioIn (d1u9s7t8r)ia. l
ijv Q> .71
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A dditional Papers and P a rticip a tio n in Various Symposia and S c ie n tific C onferences Dr. Hay i s sending a l l w r itte n docum ents, w hether p u b lish ed or nonpublished, to supplem ent th is Summary, in clu d in g N os. 2 ,3 ,5 and 7, and these w ill be attached and incorporated by referen ce to th is Supplemental Summary.
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RONALD H. KERMAN, Ph.D.
V. GROUNDS FOR EACH OPINION
A. General Dr. Kerman has been doing a study in Houston, Texas in connection w ith h is work at the U niversity of Texas M edical School, Houston, Texas, w ith a study known as the Texas Agent Orange Study, which has review ed the m edical h is to r ie s and records and done te s tin g on Vietnam v etera n s who are r e s id e n ts o f Texas and who have gone to the VA H o sp ita l fo r treatm en t. At th is tim e, Dr. Kerman is unable to send h is underlying data sin c e the data has been given to the computer for a n a ly sis and for confirm ation. The u n d erlyin g data and the fin a l summary and r e s u lt s should be a v a ila b le w ith in two weeks and w ill be provided im m ediately to a ll p a r tie s of in te r e s t and to the Court ju st as soon as p la in tiffs receiv e said inform ation from Dr. Kerman.
MARVIN S. LEGATOR, Ph.D.
V. GROUNDS FOR EACH OPINION
A. General Dr. L egator's train in g and p ro fessio n a l experiences have been in the general fie ld s of toxicology with major emphasis in gen etic to x ic o lo g y . He has prepared, o ffe r e d and taught cou rses fo r both m edical stu d ents and graduate students in the areas of gen etic reproductive mutation and to x ic o lo g y . H is current research among oth er areas has to do w ith the e ffe c ts of chem icals as they a ffe c t sperm; s p e c ific a lly , d etectin g a n o n -d isju n ctio n error in sperm which produces an in crease in the number o f Y b o d ies by flu o r e sc e n t s ta in in g . He i s e s p e c ia lly in te r e s te d in the area of male mediated e ffe c ts and in th is regard he and h is colleagu es at the U niversity of Texas M edical Branch have been evaluating the e ffe c ts of chem icals in rodents looking for adverse h ealth outcomes and sp e c ific a lly b eh avioral anom alies. They have recen tly published a se r ie s of a r tic le s regarding behavioral anomalies after adm inistering selected chem icals to the m ales and evalu atin g the F -l progeny. A d d itio n a lly , they are a lso working on the e ffe c t of chem icals a fte r in utero exposure of anim als, s p e c ific a lly they are showing the types and frequency of chromosomal anom alies to the fetu s and pregnant fem ale. Dr. Legator therefore b elieves that he has rather broad experience in the area of toxicology, genetic toxicology, reproductive e ffe c ts, teratology and male mediated e ffe c ts of chem icals. It should be empahsized that he has been involved in several expert com m ittes having to do w ith the e ffe c ts o f dioxin -in d u ced adverse h ea lth hazards includin g reproductive and g en etic e ffe c ts , a ll of which are
noted on h is curriculum v ita e p r e v io u sly su p p lie d . He w ill review and rely upon a ll of the availab le m edical records for both P la in tiff Jordan and P la in tiff Ryan.
In a d d itio n , Dr. L egator may r e ly upon the fo llo w in g r e fe r e n c e s:
Bioaccumulation
Matsumura, F. and H.J. Benezet. 1973. Studies on the b io ac cur ul at i o n and microbial degeneration o f 2 , 3 , 7 , 8 - t e t r a c h l o r o d i b e n z o - p d i o x i n . Environ. Health Perspect. 5: 253.
C arcinogenicity
Gerry, D.L. et a l . 1972. Studies wi th ch l o ri n a t e d dibenzo-pd i o x i n s , pGlybror.:ir.3ted biphenyls, and po ly c h lo ri n a te d biphenyls in a t'.vo-stacie system o f mouse skin tumorigenes is : potent a n t i c a r c i n o Genic e f f e c t s . Ar.r:. N.Y. Acad. Sci. 320: 405. DiGiovanni, J . , A. V i a j e , D.L. Berr y, T.J. Slaaa'and M.R. Ouchau. 1977. T u m o r - i n i t i a t i n g a b i l i t y o f 2 , 3 , 7 ,8- tet r a ch lo rn d ib e n zo -p d i o x i n fTCDD) and Arcchlor 1254 in the two-stage system o f mouse skin carcinogenesis. B u l l . Environ. Contam. Tox icol. 18: 552. DiGiovanni, J . , O.L. r<e'*ry M.R. Juchau and T.J. Slaqa. 1979b. 2 , 3 . 7 ,5 -Te tn ch ]o re d i terzo p - d io x in : potent anticarcinogenic act1 v i t y in LD-1 mice. Biochem Biophvs. Res. Comm. 85: 577.
P i t o t , H.C., T. Goldsworthy, H.A. Campbell and A.' Poland. 1980. Q ua nt ita tiv e evaluation o f the promotion by 2,3,7 , 8 - t e t r a c h l orodibenz:-p-dioxin of hepatocarcinogenesis from diet*' nitrosamine Can. Res. 40: 3516-3620.
Toth, K. , S. Somfai-Re 11e , J. Sugar and J. Bence. 1979. Carcino g e n i c i t y of herbicide 2 , 4 , 5 - t r ich 1oro-phenoxyethanol- c o n t a i n i ng d i o x i n and of pure d i o x in in Swiss mice. Nature 279: 548.
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Enzyme Induction
uiG io va rn i, J . , D.L, Derry, T.J. Slaqa, A.H. Jones and M.R. Juchau. 197nd . Effects of pretreatment w i th TCDD cn the capacity o f hepatic and excraheoatic mouse tissu e s to convert prncarcinogens to mutagens f o r 5. t yphirm.T'ion auxotrophs. To x ic o l. Ape1. Pharmacol. 50: 229.
General Toxicology
Grieo, J.B. ana F. DeMatteis. 1973. Effec ts o f 2 , 3 , 7 , 8 - t e t r a c h l o r o diherizn-p-dioxin on clru'" metabolism and hepatic microsomes o f ra ts and mice. Environ. Health Perspect. 5: 211.
Jones, G. and J.E. Grieg. 1975. Pathological changes in the l i v e r of mice given ?. , 3 , 7 , 8 - te t r a c h l orodi benzo-p-dioxin. Experientia 31(11): 1315-1317. McConnell, E.E., J.A. Moore, J.K. Haseman and M.W. H a rr i s . 1978b. The comparative t o x i c i t y o f c h l o r i n a t e d dibenzo-p-dioxins i n mice and guinea pigs. T o xi col . Appl. Pharmacol. 44: 335.
G enetics
K o u r i , R.E. and ...W. Hebert. 1977. Genetic re g u l a t i o n o f suscep t i b i l i t y to p o l y c y c l i c hydrocarbon-induced tumors in the mouse. _In: Proc. Symp. Origins o f Human Cancer. Cold Spring Harbor, N.Y.
Mechanisms of Action
Meal, R.A., P.W. Beatty and T.A. Gasiewicz. 1979. Studies o f the mechanisms of t o x i c i t y o f 2 , 3 , 7 , 8 - t e t r a c h l o r o d i b e n z o - p - d i o x i n (TC7'). Ann. M.Y. Acad. Sci. 320: 204.
M etabolism
Chinbra, R.S. et a i . 1974. S ele cti on o f inducers as an importance factor- in characterizing genetic differences to induction or aryl hydrocarbon hydroxyl as* i n s t r a i n s o f mice. L i f e Sci. 15: 123. : ^ 3 * 7 ^ 0
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5
Metabolism (Cont'd)
Guenther, T.M., J.M. Fysh and G.W. Hebert. 1979. 2 , 3 , 7 ,8 - T e t r a chl orc.ii benzo-p-o : oxi n: covalent binding o f rea ctive metabolic
i1nl.t-e2r2m. ediates p r i n c i p a l l y to p r o te in in v i t r o . Pharmacology (19) 1 :
Lu ci er, G.W. e t a l . 1973. TCDO-induced changes in r a t l i v e r microsomal enzymes. Environ. Health Perspect. 5: 199.
K o u r i , .R. 1976. Relationship between le v e ls o f aryl hydrocarbon hydroxylase a c t i v i t y and s u s c e p t i b i l i t y to 3-methylchoianthrene and benzo(a)-pyrene-induced cancers in inbred s t r a i n s o f mice. In: R.J. Fr e u d f' th a l and P.W. Jones (e d s . ) , Polynuclear aromatic hydrocarbon:: chemistry, metabolism and carcinogenesis. V o l . 1. Raven Press, H.Y. p. 139.
Poland, A.P. and E. Glover. 1973a. Chlorinated d ib e n z o -p - d i o x i n s : potent inducers o f u- Am in ol ev u li ni c acid synthetase and aryl hydrocarbon hyaroxylase. I I . A study o f the structure a c t i v i t y r e l a t i o n s h i p . Molecular Pharmacol. 9: 736.
Poland, A.P. and E. Glover. 1973b. 2,3 ,7 ,8 -T e tra chl or o di be nz o- pdioxin: a potent inducer of u-Aminolevulinic acid synthetase. Science 179: 476.
Poland, A.P. and E. Glover. 1974. Comparison of 2 , 3 , 7 , 8 - t e t r a chlorodibenzo-p-dioxin a potent inducer of aryl hydrocarbon hydroxylase w it h 3-methylcholanthrene. Mol. Pharmacol. 10: 349.
Poland, A.P. and E. Glover. 1979. An estimate o f the maximum in_ vivo covalent binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to rat T lv e r p r o t e i n , ribosomal RNA, and DMA. Cancer Res. 39: 3341.
Poland, A.P. and A. Kende. 1976. 2 , 3 , 7 , 8 - t e t r a c h lo r o d i b e n z o - p d i o x i n : environmental contaminant and molecular probe. Fed. Proc. 35: 2404.
Poland, A.P., D. Smith, G. Metier and P. Possick. 1971. A health survey o f workers in a 2,4-D and 2,4,5-T p1a. t. Arch. Environ. Health 22: 316.
Poland, A.P. et a l . 1974. Genetic expression o f ar yl hydrocarbon hydroxylase a c t i v i t y indu ction o f mono-oxygenase a c t i v i t i e s and cvtochrome P-l-450 formation by 2,3,7,8-TCDD in mice g e n e t i c a l l y . Jour. B i o l . Chem. 249: 5599.
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Mutagenicity
( i r c /\ S. and F.S. Moreland. 19" 5. Cytogenetic evaluation o f several dio xins in (.hr; r a t . T o x i c o l . -Appi. Pharmacol. 33: 161.
Hussain, f . , L. Ehrenberg, G. Lo fro th and T. G e j v a l l. 1972. Muta genic e f f e c t s o f TCDD on b a c t e r i a l systems. Ambio. 1: 32.
S e i l e r , J.P. 1973. A survey on the mutagenicity o f various p e s t i cides. Experientia 20: 622.
Pharm acokenetics and D istrib u tio n
A l l e n , J . R . , D.A. B s r s o t t i , -J.P. Van M i l l e r , L.J. Abrahanson and J . J . Laucri. 1977 . Morphological changes in monkeys consuming a d i e t containing low levels o f TCDD. Food Cosrnet. To xicol. 15: 401.
T era to g en icity
Berry, D.I.. et a l . 1376. Transplacental induction o f carcinogen h y d r n x i y l a f ing systems with 2,3,7 , 8 - t e t r a c h l o r c d i b e n z o - p - d i o x n . Toxicol. Appl. Fi' -.rrrv'. c o l . 36: 569.
i-hera, K.S. and J.A. Roddick. 1373. P c ly cM or o di bs n zo- p -d io xi n s: prenatal e f f e c t s and in dominant le t h a l t e s t in Wistar r a t s . In: E.D. B l a i r ( e d . ) , Chi r.rcd'-cmns - o r i g i n s mi fate. Adv. Chem. Ser. , No. 120. Am. Chem. See., Washington, D.C. p. 70.
Moore, J . A . , B.M. Gupta, J.G. Z i n k ! , J.G. Vos. 1973. Postnatal e f f e c t s o f maternal -nesure to. 2 , 3 , 7 , 8 - te t r a c h l o r o d i b e n z o - p - d i o x i n (TCDD). Environ. He. tf Perspect. 5: 81.
Smith, F . A . , B.A. Schwetz and K.D. Nitschke. 1975. T e r a to o e n i c i ty o f TCDD in CF-1 mice. To xi col . Appl. Pharmacol. 38: 517.
Sparschu, G.L., F.L. Dunn and V.K. Rowe. 1971. Study o f the t e r a t o g e n i c i t y of TCDD in the r a t . Food Cosrnet. To xi col . 9: 405.
C ourtney, K .D ., D.W. G aylor, M.D. Hogan and H.L. F a lk , 1979 Teratogenic evaluation of 2,4,5-T , Science 168: 864.
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137 V
ALAN SCOTT LEVIN, M.D.
I I . SUBJECT MATTER
Dr. Levin w ill d iscu ss c lin ic a lly , uses of the epidem iologic approach, i.e . c lin ic a l epidem iology. Dr. L evin's a r tic le which has been previously submitted and the paragraphs which describe the harmful e ffe c ts th a t 2,4-D and 2,3,7,8-T C D D , as w e ll as o th er d io x in s , have on th e immune system w ith referen ce to (1) r e p r e se n ta tiv e c la s s p l a i n t i f f s whom Dr. Levin has te ste d ; (2) n o n -rep resen ta tiv e c la s s p la in t if f s or Vietnam v etera n s; and (3) o th ers. Dr. Levin has performed c lin ic a l stu d ies on th ese three general c a te g o r ie s of people w ith in h is own p r a c tic e and the u n d erlyin g data which w ill form the b a sis of these opinion s are attached and incorporated h erein .
IV. SUBSTANCE OF OPINIONS C. Dr. Levin w ill use the c lin ic a l data which he has provided in
resp on se to th is supplem ent to h is Expanded Summary to form h is o p in io n s related to the causal relation sh ip of the various Agent O range/dioxin-related adverse health e ffe c ts upon the in d ivid u al rep resen tative c la ss p la in tiffs th em selves whom he has in d iv id u a lly te s te d . These documents are a tta ch ed to th is supplement.
V. GROUNDS FOR EACH OPINION A. General The b a sis for such fa c ts and opinions expressed h erein by Dr. Levin
in clu d e h is review of the m edical and s c ie n t if ic lite r a tu r e , s p e c ific a lly
137S8
3
those documents which Dr. Levin has attached to h is curriculum v ita e Addendum and the b ib liograp h y attach ed to Dr. L ev in 's a r t ic le , which was p reviously subm itted; h is personal research and c lin ic a l experiences as o u tlin e d under I I above and IV above, which c lin ic a l data i s atta ch ed and incorporated herein for a ll purposes; and h is personal knowledge of the d e fo lia tio n of Vietnam; and h is review of a ll p ertinent m edical data of the r e p r e se n ta tiv e p l a i n t i f f s , p a r tic u la r ly w ith resp ect to op in ion IV C. In th is regard, Dr. Levin w ill have reviewed a ll m edical records and data of the rep resen tative p la in tiffs which has been submitted to the defendants and which Dr. Levin has reviewed prior to givin g h is d ep osition testim ony.
Curriculum V itae - Bibliography R eferences The referen ce to E sp o sito , N .P ., T.O. Tiernan and F.E . Dryden, 1980, D ioxins, prepared for In d u strial P ollu tion Control D iv isio n , U.S. EPA, C in c in n a ti, O hio, C ontract N os. 6 8 -0 3 -2 5 7 7 , 6 8 -0 3 -2 6 5 9 , and 68-0 3 -2 5 7 9 , EPA 6 0 0 /2 -8 0 -1 9 7 , i s the f u l l th e c i t e on the E sp o sito document referred to be Dr. Levin. D.r. L e v in 's f u l l r e fe r e n c e s and any m a te r ia ls he w i l l use which are not published are attached hereto and incorporated herein for a ll p u rp oses. A summary o f h is fin d in g s on the in d iv id u a l r e p r e se n ta tiv e c la s s p la in tiffs w ill be furnished and attached to th is supplem ent, as w ell as h is underlying c lin ic a l data for such opinions.
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PETER ORRIS, M.D.
I. QUALIFICATIONS
Dr. O rris' testim ony w ill be given as a p riv a te c itiz e n and not as a NIOSH M edical O ffic e r . F u rth er, the research he i s cu r r e n tly in v o lv ed w ith irt S t. L ouis concerns truck d r iv e r s p o t e n t ia lly exposed a t tru ck in g term inals in S t. L ouis, not Times Beach. This work w ill be explained in d eta il below.
V. GROUNDS FOR EACH OPINION A. General The p ro jects which are described below are s t i l l pending and w ill
not serve as a basis for Dr. O rris' opinions. Dr. O rris' research a c tiv itie s include looking in a q u a lita tiv e
manner at the veterans that he has seen at Cook County H osp ital searching fo r p h y sic a l in d ic e s th at would in d ic a te d egree o f exp osu re. He has not done th is in a system atized approach y et, but it is being considered.
Through the D iv isio n of O ccupational M edicine at Cook County H ospital, he is cooperating with Local 600 of the International Brotherhood of Team sters and the C entral S ta te s' Pension Fund of the Team sters' Union to review the m orbidity experienced between 1976 and 1983 of team sters p o te n tia lly exposed to d ioxin in 1972 during th eir employment' in and around three trucking term inals in St. Louis, M issouri. These term inals were sprayed dm 1972 w ith an o i l co n ta in in g d io x in s in an e f f o r t to reduce d u st. He w ill be u t iliz in g the h e a lth in su ran ce cla im s f ile d w ith the C en tral S ta te s' Teamster Fund for th is group o f team sters and comparing i t
a su itab le control group of team sters not so exposed. A gain, through the D iv isio n of O ccupational M edicine a t Cook
County H osp ital, he is cooperating w ith the W isconsin Veterans A dm inistration and the Woods VA H o sp ita l in M ilwaukee, W iscon sin , as w e ll as se v e r a l Veterans A ssociations in W isconsin to evaluate the p o ssib ility of u tiliz in g twin p airs in an in v e stig a tio n of Agent Orange exposure. These approxim ately 61 twin p a irs had one member in Vietnam and the oth er member not servin g in Vietnam. The in it ia l stage of th is study is the d istrib u tio n to these twin pairs of a questionnaire prepared at the D ivision of O ccupational M edicine. This questionnaire attem pts to assess whether a h istory of exposure to Agent Orange can be acquired in th is manner. I t a lso is an attem pt to see whether th ere are enough twin p a irs in which one member has a c le a r h isto r y o f exposure to Agent Orange and the oth er member has no sig n ifica n t confounding exposures in order to determ ine whether i t is fe a sib le to proceed w ith more in depth health h isto r ie s and p h ysical e v a lu a tio n s. To r e s t a t e , th is q u estio n n a ire i s d esign ed to a s s e s s w hether an exposure h isto ry can be illic it e d and a d iffe r e n tia l exposure experience determined for these twin p a irs. This questionnaire has been prepared and is currently being sent out. It w ill go only to the State of W isconsin.
In the N ational In stitu te for Occupational Safety and H ealth, he has been involved in research in to exposures of fir e fig h te r s and others involved in transformer e le c tr ic a l fir e s. These fir e s have engended a p ossib le exposure to dioxins through the fact that the transform ers are bathed in o ils containing polychlorinated biphenols and chlorinated benzenes. When th ese su b sta n ces are burned above 5 0 0 , th ey may produce fu ran s and d io x in s . NIOSH (H azards and T ech n ical E v a lu a tio n s Branch fo r w hich Dr. O rris works) has look ed a t many o f th e se f ir e s in v a r io u s area s o f the cou n try. He has been in v o lv ed in S t. P a u l, M innesota and C hicago, I l l i n o i s .
'
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These as yet are not published. When e v a lu a tin g p a tie n ts fo r p o s s ib le TCDD in to x ic a tio n , Dr.
Orris uses certain indices in attem pting to reach a diagnosis. A lis t of these elem ents is attached.
B. Specific Acne - The Veterans A dm inistration review e n title d "Review of the L iteratu re on H erbicides Including Phenoxy H erbicides and A ssociated D io x in s, V ol. 1 , prepared by JRB A sso c ia te s fo r the V eterans A d m in istration under Contract No. V101(93) P-823, dated October, 1981. A d d ition ally, " E sp osito" , which i s th e EPA p u b lic a tio n e n t it le d "D ioxins" EPA 6 0 0 /2 -8 0 -1 9 7 , November, 1980 by E sp o sito , Tiernan and Dryden. A rchives of Environmental H ealth; "The Development and P rognosis o f Chronic I n to x ic a tio n by T etra ch lo ro d ib en zo -p -d io x in in Men" by Jana Pazderova-Vejlupkova, M.D., et a l . , V ol. 36, No. 1, January-February, 1981. B ritish Journal of Industrial M edicine, "Tetrachlorodibenzo Dioxin: A Survey o f S u b jects Ten Years A fter Exposure" by G. May in V ol. 39, pp. 128-135, 1982. Journal of Occupational M edicine, "M ortality Experienced of Employees Exposed to 2 ,3 ,7 , 8-te tr a c h lo r o d ib e n z o -p -d io x in (TCDD)" by Ralph R. Cook, e t a l . , V ol. 22, No. 8 , A ugust, 1980. Journal of O ccupational M edicine, "The M ortality Experienced of Workers Exposed to Tetrachlorodibenzo D ioxin in a Trichlorophenol Process A ccident" by Ju d ith A. Zach and Raymond R. Suskind, in V ol. 22, Nol 1, January, 1980. "Environmental Chloracne Update and Overview", James S. T aylor, Annals of the New York Academy o f S c ie n c e , 1979. (Volume unknown)
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Liver Effects - Veterans' Administration review and the
E sp o sito EPA document, as w e ll as: "Halgenated B iphenyls, Terphenyls, N apthalenes, D ibenzodioxins
and R elated Products" edited by Renata D. Kimbrough, published 1980, E lsev ier/N o rth H olland B iom edical P r e ss, 1980, Amsterdam, New York and Oxford.
"Chemical Porphyria in Man", ed ited by S tr ik , J.J.T .W .A . and Koeman, J .H ., a lso E lseiver/N orth Holland Biom edical P ress, 1979, Amsterdam, New York and O xford.
"Dioxin, T oxicologic and Chemical A spects", ed ited by C attabeni, F lam in io, C a v a lla ro , A ldo, G a lli and G iovanni, p u b lish ed by SP M edical and S c ie n t if ic Books, New York, London, 1978.
"Chlorinated d ioxin s and R elated Compounds: Impact on the Environment" Proceedings of a Workshop held a t In s titu to Superiore D is a n ita , Rome, I t a ly , 22-24 O ctober, 1980, e d ite d by 0 . H u tzin ger, R.W. Frey, E. Marian and F. P o cch ia ri, published by Permagon P ress, 1982.
"The Development and P rognosis of Chronic In to x ic a tio n by T etra ch lo ro d ib en zo -p -d io x in in Men" by P azderova-V ejlupkova; A rch ives of Environmental H ealth, 1981.
"Hepatic Porphyria Induced by 2 ,3 ,7 , 8-tetra ch lo ro d ib en zo -p -d io x in in the Mouse" by J.A . G o ld stein , e t a l. in R esearch Communications in Chemical Pathology and Pharm acology, V oi. 6 , No. 3 , November, 1973.
Personal communication from Dr. J.J.T.W .A . S trik concerning p a tie n ts seen a t Cook County H o sp ita l, S ectio n o f O ccupational M edicine, on July 17, 1981 (attached h ereto ).
T oxicology and Applied Pharmacology, V oi. 57, No. 2, pp. 156-163, C an ton i, L ., M. Salmona and M. R iz z a r d in i " P orp h yrin agen tic E ffe c t o f Chronic Treatment with 2 ,3 ,7 ,8 tetrach lorod ib en zo-p -d ioxin in Female R ats,
Dose Effect Relationship Following Urinary Escretion of Porphyrins.
P erip h era l Neuropathy - Here as w e ll, the VA rev iew , page 6 -2 6 ,7 and E sp o sito , th e EPA book, p. 214.
Pazderova-V ejlupkova, "The Development and P rognosis of Chronic I n to x ic a tio n by T etra ch lo ro d ib en zo -p a ra -d io x in in Men" from the A rch ives of Internal M edicine, February, 1981.
"Human H ealth E ffe c ts from A c c id e n ta l R elea se o f T etra ch lo ro d ib en zo p -d io x in TCDD a t S eveso, Ita ly " ; Franceso P o c c h ia r i, V itto r io S ila n o , and A lfred o Z am oieri, 1979, Annals o f New York Academy o f S cien ce (Volume unknown).
N europsychiatrie Disorder
Archives of Environmental Health from Czechoslovakia; "The
Development and Prognosis of Chronic Intoxication by Tetrachlorodibenzo-
para-dioxin in Men".
Soft Tissue. Sarcomas It S oft T issue Sarcomas and Exposure to Chemical Substances: A Case R eferen ce Study" by M. E rik sso n , L. H a r d e ll, N.O. B erg, T. M oller and 0. Axelson, B ritish Journal of Industrial M edicine, Vol. 38, pp. 27-33, 1981. "Case Control Study: Soft T issue Sarcomas and Exposure to Phenoxy A cetic Acids and C hlorophenols; L. H ardell and A. Sandstrom, B ritish Journal of Cancer, Vol. 39, p. 711 follow ing 1979. " R elation o f S o ft T issu e Sarcoma, M alignant Lymphoma and Colon Cancer to Phenoxy A cids and C hlorophenols and Other Agents" by Lennart H a rd ell, Scandanavian Journal o f Work and E nvironm ental H ea lth , V ol. 7, pp. 119-130, 1981.
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*
L etter in the Journal of American M edical A sso cia tio n , June 17, 1983, V ol. 249, No. 23; "Dioxin Exposure and Sarcoma" by M arilyn A. F in gerh u t, P h .D ., W illiam E. H alp erin , M.D. M.P.H.
Lymphoma H a rd ell, L ., E rik sson , M ., Lennerp Lungren, E ., ''M alignant Lymphoma and Exposure to Chemical Substances, E sp ecia lly Organic S olven ts and Chlorophenols and Phenoxy A cids: A Case Control Study" B ritish Journal of Cancer, V ol. 43, pp. 169-176, 198.1.
G astric Carcinoma "M ortality Study of Persons Exposed to Dioxin in a Trichlorophenol P ro cess Accident" th at occurred in the BASF AG on November 17, 1953; A.M. T h ie ss, and R. F ren tzel-B ey en e and R. Link; American Journal o f Industrial M edicine, Vol. 3, pp. 179-189, 1982.
Co fonPgeernsoitnasl DExepfeoscetds itno DthieoxOinf_f_s_p__r_in__g_s In the D ioxin E sposito Book and the review of the lite r a tu r e from the V eterans A d m in istration , as w e ll as a r t ic le s by Dr. Ton That Tung, e n t it le d "The M u tagen icity o f D ioxin and i t s A ffe c ts on R eproduction Among Exposed War V eterans" (no d a te ). " E ffe ts D e l'u t ilis a t io n M assive Et C ontinue De D e fo lia n ts Sur Lapopulation C iv ile" , Tung, T .T ., unpublished work relea ses by the authors in Hanoi in July 20, 1969; A d d ition ally, Le Problme Des E ffets Mutagenes Sur La Second G eneration Apres L 'E xp osition Aux H erb icid es" , 1979, and a tra n sla tio n by J. Davidson.
-6-
5
M etabolism o f TCDD Kimbrough's book: H alogenated B iphenyls, T erphenyls, N apthalenes, D ibenzodioxins and R elated Products". The VA study and E s p o s ito 's work. Lipid Abnormalities VA review and E sp o sito Increased Breaks and Gaps in Other Chromosomal A b n o rm a lities._______________________________________ Reference to E sposito, p. 229.
-7-
Your reference
Your letter of
Our reference Date
Enclosure(s)
s71e73v7J./8u1lyJH1/9M81V
Dr. Peter Orris Section of Occupational Medicine C18o3o5k VC/.ouHntayrrHisoonsp iStatrl e e t CUShAicago, HI. 60612
Subject
Dear Dr. O rris,
I a p p recia te i t very much to be con tacted on in te r p r e ta tio n o f urinary porphyrin p attern s. In your appendix you mentioned normal v a lu e s o f co p ro - and uroporphyrin w ith in th e mg range. I th in k th is have to be |jg. Looking to your data I lik e to make the follow in g remarks:
P atien t no
(our nToromtaall praonrgpeh:yr0in-2sC0 yg)
COP>ROa/,U3R.O5 -4r .a0tio
1 2 g5
increased increased normal in c r e a se d
ddeeccrreeaasseedd decreased normal
10 normal decreased
13 14
normal normal
decreased decreased
Important would be to determ ine tha urinary porphyrins sep arately e .g . uroporphyrin, h ep tacarb oxvlic, hexacarboxylic, pentacarboxylic- and pcooprrpohpyorrinph. yTrhineseto tweos t aoborlipshhvrainnys ainrec r einadseic aint ivthe e fourrol-ivaenrddahmeapgtaecacrabuosexdyl i c bnyo tpaorpr ehayrl indoicsreeansiec chs teamt iec.a lTs .h eAresfmoraell I inhcorpeea yseoummeaaynshaavef i rths et pinodsisciabtiiloint y to assess the porphyrin pattern. Because there also might be a p o ssib ility of g en e tic a lly determ ined porphyria, a fam ily anamnese could be important too. Enclosed you w ill fin d some r e p r in ts. One. is o f sp e c ia l value to yInouc. o oI tp eirsa toionn Vwieittnhamthve emteerda incsal frdoomc.toAru wster asltiiair st urfefeserainr cgh moenntbarl adinis eeaf fsee.c t s . Maybe you can comment on th is su b ject?
Kind regards,
Dr. A. Strik
ni
Africnliursl 'Jriiversity/biOiCcii.'ioii/Dc Drcijcn 12/6703 BC VV-.ipinmsen/The Neclicdumls/Tel. (03370) 32137
June 3, 1981
Dr. J.J.T.W.A. Strick Department of Toxicology Agriculture University Wageningen, Netherlands
Dear Dr. Strick:
I have taken the liberty of writing you today concerning your work on Chronic Hepatic Porphyria and its relationship with chlorinated polycvclics. During the past year, we have seen a number of Viet Nam. veterans here at the Section of Occupational Medicine at Cook County Hospital., Cook County Hospital is a large public hospital situated in Chicago v/ith 3.400 beds and 750,000 out-patient visits a year. The Section of Occupational Medicine provides Occupational Consultative Services to patients in the hospital and on an Out-patient bases. Additionally, we have a joir.t Internal/Occupational Medicine Residency Training program that is currently affiliat with Northwestern University Medical School.
The- Viet Nam veterans that we have seen over the past yea have ccma to us v/ith multiple systemic complaints that, they believe have been caused by their e x p o s u r e to 2,3, 7, 8 tetra chlcro-dibenzo-parn-dioxin,as an impurity in the Herbicide Agent Orange. In the process of researching the literature concerning these toxic exposures, we discovered your book "Chemical Prophyria in Man" published in 1979, and your art.icl in the Annals of the New York /Ic.aderr.y cf Sciences, Volume 230, June, 1979. On the basis of this information and discussion with others in the field, we decided to secure 24-hour urinary quantitative porphyrins on some of these patients. Cur laboratory could only supply us with values for uro-porphyrins and copro-porphyrins. The results are listed in Appendix I.
This, of course, is a small cohort, that is self selected whose exposure is not documented, and whose other exposures are uncontrolled. Despite' this we found these results interas but wonder what is the range within the normal population. Further, we were unclear as to how' much weight can be placed upon abnormal rations with normal quantitative results. We would be interested in your comments on this situation. And further, if you could direct us to the publishing house in the
Dr. J.J.T.W.A. Gtrick Department of Toxicology Agriculture University Wageningen, Netherlands
United States that carries your book, "Chemical Porphyria in Man", we should liJ:e to order a copy. Thank you very much for your consideration of this matter. t'Je are looking forward to your thoughts.
Sincerely
Peter Orris, M.D., M.P.H. Attending Physician Section of Occupational
Medicine Cook County Hospital
1t-',IHT 11 PORPH! YJR, -iI'N1S! 1` -
/ URO. SYMPTOMS
__________ ______
jc'-ALA ?:.ko
Arthalg ia
. GFeonrpreho -= 0lu.3i
161/ .85 = .87
MMay1aa1gi s1ca
'ir - 135
Pa r e s t has ia
j:Copro = G^i Uro = 185
Bk, A rth s1g i a ' 5 k = 1.55 Mya l g i 0
---------- ;:.----------------------------------------------------1---------------------------- 1 MP aarlacistshe e s i a
Copro - i2S . ' ,Uro = 38
jS'DALA 1 . SO
;PEG 0 .4
,
|.UCroopro
" 15
/16C
j 123, I '33 = 3.6 IJ _____
76/13 = 4.2
A rthalgla Mya1g i a MP aa1raeissteh e s ia Mya1g i a MP aa1racissthe e s ia
/JALA = 2 .7 0
vorpho = 0.3
' 'Cvpro hrj
,;!rn - 17
r
l:/'aGla`
"~~* --
6". 3*1 0.5
.Copro = SO
.Uro = 7
CALA = 4 .7 7 j'CG = 0 .8 'Cooro = 27 )Jro = 2
<
PALA 3-0 P3G = 0 .7 Copro = l4 i Uro = 3 i1 j
,|
Ar th o 1g i a 4 6 /1 7 2 .7 Mya1g i a
Pares thes ia
80/7
=
11.4
Art ha!g ia Mya 1g i a
Pares thes ia
Ar th a 1g i a 2 7/2 = 13.5 Malai se
Ma1a i sc lA l/S = 17-6 Paresthcs ia
''i!!. . 1! ..
ALCOHOL CONSUMPTION
3+
-
2+
V OTHER CLINICAL ABNORMALITIES ' ' ^ X * 1
memory lo s s
h'/O paranoid s c h iz .O
decrease libido
HGP
CO
rash developed after exp.
CO
. . ...
memory lo s s
in crease chromosomal damage
h osp ital for mental health pi no flye cryt si ltiitcy kidney t e s t i e s
0 apnoxlyiectyys t ic k id n eysn a u sea , vom itin g rash
--
decrease libido tempernon to 1, nervous 1+ sk in pa in c r a c k lin g , in c r e a se pigm ent
unable to have children X 2 yrs.
0
vorni tin g rash
S.O .B . (h'/0 T/B) c y s t ic sk in le s io n s 0 D ecrease memory d ecrease h earin g
rash ( t 'n i gh) turn i t i s
rash 0 ataxia
d ecrea se memory
PATICHT KC.
OHANTIATIVr r Ol.f' iIY'. I HS
corno/
u;;c.
SYMPTOMS
ALCOHOL
CONSUMPTION OTHER CLIMI CAL ASORNALIT!LS
II
\j->
13781
OO o-1r\
o\ II
PDLA'GLA == Copro
3 . 3O 0.2
Uro = 30
375/30 = 12.6
Art ha 1g i a iya ! pi a MPaalree!ssteh e si a
a n x ie ty
photophobia
d ep ressi on
i nscr.n i a
0 rash decrease libido
DrC-Aor cLpAr o==
11.
5.5 1
0
Uro = 51
3^/51 = .66
Mo1Ui s e Paresthes i0
Linivc rere a ssceanSG0-Tparenchyma terns D isc 3+ rash
DI'AliIGA =
-'i. 1
O.3
Copro - -52
Uro = 1 1
52/11 k.7
A n 1.11<1i a
M1*0o1lea
s i
lh sc
e
s
t
a
Mya 1g 1a
lief* i nil
i!e-: 1r.V.e 11. 1ill i
H- sk in rash anx i e i.y
headaches
focal p ro!, g lor cru
1onechr ?t i s
12. DALA = 6 .0 0
PBG = 0 .6 UCcrpor.=o hC= 13
ihS/kO = 3.7
13-
PDDAGLA= =0 .6 4 . 5 0 Copre = 101
101/50 = 2.0
Uro = 50
14.
DALA = 11.30 PDG = 1 . 2 Ccpro = 1QA
104/37 = 1.19
Uro = 87
/
U1._t i Por; Cepr Urop
in epo orp
rnrj/24 h i 1 i r.cejen rphyrin hyrin in
r. Horma 1
iniiin.fri/r?n.ghg/2/lk2i-rl.h
hr r.
: 0-7.00) . (Honro
(l.'or.T.ol (1o rir.n I :
:1:o,9. " 0 -'i0 )
-!i.
)
Arthaly ia M yalgia HPaalraesi tshe es i a Ma 1a i se
P a resth esia
3+ s i1n5c7e':; 0 0
depress ion tem poral he^
c
aHch/0es
drug
O.B.
1S&3
(sev era 1/w eek)
lower back pain hematuria d ecrea se lib id o d ecrease memory co n g en ita l d e fe c ts in c h ild .
1+
pseeriszounrael dtyis memory lo ss
o<:rrd.raaenrsghse
depression (as cnrxoietaty!)
headaches
weight loss
-
FJ'Tr''.......... r' ~ " ' S DH L'UTILISATION MASSIVE ET CONTINUE DE DEFOLIANTS SUR LA POPULATION CIVILE (ETUDE LIMINAIRE)
(TON THAT TUNG, TRINK KIM ANN, BACH QUOC TUYEN, DAO XUAN TRA, NGUYEN XUAN HUYEN (HANOI)
Chargs par l 'A sso c ia tio n G nrale des M decins de la Rpublique Dm ocratique du Vietnam d 'enquter sur le s e ffe ts clin iq u es de l 'en p loi d 'herb icid es et de d fo lia n ts sur la population c i v ile , nous avons tu d i un groupe d 'h ab itan ts du Sud Vietnam en exode dans le Nord . De c e t t e lim in a ir e , sem blent se dgager certa in s f a it s d 'une gra v it p a r tic u li r e : 1 'u tilis a tio n m assive e t prolonge d 'herbicides e t de d fo lia n ts peut amener des a lt r a tio n s chromosomiques sur la p o p u la tio n v iv a n t dans le s zones d 'pandage, e t peut mme provoquer des aber ration s chromosomiques avec m alform ations co n g n ita les. Ht ERIEL D'ETUDE ET METHODES D'EXAMEN*1 Sur un to t a l de 903 personnes com poses d 'h a b ita n ts du Sud Vietnam en exode au Nord e t groups dans le s h p itaux ou dans le s ce n tr e s d 'hb.' rgement de H anoi, nous avons pu is o le r un lo t de 179 personnes qui ont vcu sur le s lie u x d 'pandage de 2 mois 5 ans ou qui ont t directem ent victim es de l 'pandage, se rp a rtissen t on :
- 90 hcimes a d u ltes - 19 femmes a d u ltes dent 4 mres - 70 en fa n ts en tre 6 e t 14 ans 179 L' in te r r o g a to ir e c o n siste r e c u e illir le tmoignage v is u e l d 'un pandage par avion, valuer le nombre d 'pandages sur la rgion , p r c ise r le s prem iers sign es clin iq u es observs par le s malades sur eux-mmes e t estim er le s d gts cau ss aux hommes e t aux animaux. Puis on procde l 'examen gnral de ces personnes leq u el e s t p a rfo is su iv i d 'un examen s p c ia lis (examen o c u la ir e , n eu rologiq u e, p d iatriq u e ou g n tiq u e ). 3 icn entendu, avant d 'tre in te r r o g e s, to u tes ces personnes ont subi au p ra la b le un examen psychosom atique.
RESULTATS DE L'ENQUETE
On peut d is tin g u e r :
1 2
. .
un ta b lea u des effets
clinique, des secondaires
prem ires
heures
D1sTqaubelealua cblrionuiqilulaerddeschpimreiqmuieretosmhbeeusruesr le p aysage, le -- lad e prouve des picotem ents dans les yeux avec larmoiements et rhinorrhe iu teiises ; une pre edeur de ch lo re ou de DDT le s a i s i t la g o rg e, pendant qu'une fo r te se n sa tio n de c h a le u r , sem blable c e lle du piment monte aux n a r in e s. Le p a tie n t tern u e ssaens: cc ee tstsee ,sdeermn ietre vseonmsiar,tiotno urt e evnie nset ptrla isg nsaonuvt ednet cdapnhs allese eint tedr'raostghatnoiier eisn. te n Tous ces symptmes commencent s'am ender aprs 24 h eures, n a is ce n 'e s t se u le ment qu'aprs 3 4 jours que le malade poouve une sen sation do m ieux-tre.
D 'au tres m alades accusent un gonflem ent oedmateux des p a u p ires, des v e r tig e s ,
des sensations de brlure sur la peau avec phlyctnc.
_____ ______
2
V oici le tableau des symptmes : TABLEAU I
^mptnos accuss par les malades au moment de l'pandage
Mdealcaedses sysme pptlmaiegsn an t Pourcentage
Sensation de chaleur, dans le nez, rhinorrhe, ternuement Vom issem ents,parfois avec diarrhe Sensation de brlure aux yeux, larmoiements p arfois avec oedme : des--paupires Cphale, asthnie Sensation de brlure sur la peau, avec p a r fo is rythm e rp h ly .-ttn e: Tuascyhnyccoapredie avec p a r fo is v e r tig e
163 .1 3 0
130 125 73 68
91% 73%
737. 70% Al % 38 %
En somme , le s prem iers sig n e s c lin iq u e s son t c o n s titu e s par des sig n e s oculo-nasaux su iv is de cphale , de vomissements accompagns d'une sensation de m alaise, d 'a sth n ie in ten se la q u elle peut se prolonger pendant 3 ou A mois avec des larm oiem ents c o n tin u e ls . C ette a sth n ie peut r e s te r comme sig n e dominant dans le s mois qui suivent l'a g r e ssio n .
2. E ffets secondaires Les e ffe ts secon d aires'se gropent en 3 syndromes :
a) un syndrome d 'asth n ie prolonge B) un syndrome o cu la ire c) un syndrome gntique
13733
29,A5%a) des persysnodnrnoems e sed 'apslathignneien t pdro'alosnthgne ie: 3g1 nsurra l1is09e a dr cuelrtetas i,n ecs' e sset sondtira ce of fnofrint edsu raaub llei.t Apcenedt taent a2s th3n ime ,o iss,'amjoauiste nr et s tdeen tl'ianpsorm s,niinec, a pdea bllaes c d p'uhna l e , de l'im puissance sexu elle souvent et des troubles de- la m enstruation chez la femme. Une forme attnue de c e tte a sth n ie, c 'e st l'a sth n ie v is u e lle qui a ffe c te 81,3% d~ -.-i;t:.r.?. de l'p an d age. L 'preuve de la lectu re e s t tr s in t r e ssa n te . Au d b u t, la le c tu r e sem ble a i s e , r a p i d e m e n t le p a tie n t se p la in t de v o ir flo u puis de fatigu e dans le s yeux : i l abandonne a u ssit t la le c tu r e . Sur A3 personnes qui su b isse n t c e t t e preu ve, 23 lis e n t en m oins de 5 m in u tes, 9 ju sq u ' 15 m in u tes, 7 seulem ent a r r iv e n t ju sq u ' 30 m in u tes. Lorsque la fa tig u e oculaire survient, les lettres s'largissen t, les lignes se superposent : slei s leyeupxa teietndt e plear scispteh adlaensa spepsa reafifsosre nt st,. Udnes relaproms odieem5ents1, 0dme ilnautteesn sluioin pderamnset la de con tin u er la lectu re, toujours dans le s memes lim ite s . Dans sa forme la plus grave., e lle prend le-ta b lea u clin iq u e d'une v rita b le mala dexietrdm'Ae daddisyonnam:iel.'eSxaemu le,n l'celxianmiqeune dnese.crhrvom loesoambseosluampenertmrisie nde, ls'ia tcter inb 'ueesrt unue ne grave ir oxication par les d folian ts.
O bservation 1 A sthnie profonde sur une naade ayant vcu 3 ans dans une zone d'pndage : anom alies marques des chronosoncs la culture des leucocytes.
TRAN THI T R ... 47 a n s, so ig n e l'H p ita l E pour n eu ra sth n ie profonde.
A n tcdents : r ie n s ig n a le r **t p o in t de vue f a m ilia l, n a is a sjou rn do
dp19r6of6bo
al ibalne1mt9s6e8n;td)
danea
sloprulusnesq, rue'gel liloel
n e
aqs 'utit
aa3i t
ft
or
i sfsuouggrmiaiveseemdaenndst esuinntopaxabinrqdiuasgeoesuptqearrurodatieinds
iegpnaoszur
d(CeS
chapper arx oprations de ratissage.
APall'uedxiasmm eenc, hrotantiq uexet.rmement, adynamique r. la malade p a rle peu, v o ix b a sse ,
scs mouvements sont le n ts, e lle reste depuis de longs mois couche sur son
l i t . Elle rpond clairen en t et exactement aux q u estion s.
Tension a r t r ie lle : 110/80 ; pouls : 80/n ; resp ira tio n : 25/m
Rien ' .`g n a ler l'ex a n en du coeu r, des poumons e t de l'abdom en.
La malade remue tr s peu le s membres du c t d r o it ,n a is pas d 'a tr o p h ie
m u scu laire. R flex es : normaux. Examen du systm e nerveux : strictem en t n g a tif.
Examens de la b o ra to ire :
UDroseagesandgeusi_n1e7 -c: 0to,4s0t rgo/Lid e s : 4,31 n g/24 heures (2 0 /2 /7 0 ) N.G. : 3 .8 0 0 .0 0 0 GU, 7000 G B
Hmoglobine : 70%
F.L. neutre eosino lympho
35693
mono 2
Bordet Wassermann : n g a tif
C ulture des le u c o c y te s (72 h) taux d 'a n o n a lies chromosomiques 7,6% (par rapport au taux 1,14% des tm oin s).
b) syndrome ocu laire : nous avons observ le s l sio n s suivantes : - ' othenic visu elle' (vide supra) - dim inution de l'a c u it v is u e lle : l'a c u it v is u e lle e st abaisse aud esso u s de 10/10 chez 31 m alades sur 60 exam ins, (78,4%) a lo r s que le groupe vtims uoeinlledese s tsuaduvi-edtensasmouies nsde nela pnrorsemnatlee. que 26,4% de personnes dont l'a c u it
l s i-o nls s icoincsa torci cuilealilreess d:e l'leax acnoernnede dalans cournne etr aus gbrioonssiceropsrcooppoertaio nr v: 2l4,6d%es d es yeux exam ins de 65 p erson n es. On a d te c t :
- d e s cica trices su p erficielles dans la rgion linbiquo, surtout dans les secteurs in frieu rs et latraux dala corne (10 cas)
- des c ic a tr ic es sur la zone centrale de la corne (10 cas)
-- 7I 4e cjetua ds ioe-pdteerylag iocnorsne
' 13784
L'examer ophtalm ologique a permis de dcouvrir le s asp ects suivants : - n v r ite o p tiq u e .................................................................................. 1 cas - n v r ite o p tiq u e r tr o b u lb a ir e ......................... .....................1 cas - c a ta r a c te ................................................................................................. 2 cas - o p a c if ic a t io n de l'hum eur v it r e ........................................ .2 cas
c) s yndroir.g g n tiq u e .
Il co n siste en :
1/ a lt r a tio n s chroncsoniquos chez 1.-.
2/
m alfor trison
m ie
atio 21
n
s
congnitales
revt"...:
3/ nalform ations congnitales r u ltip i.
chromosomiques m u ltip les.
^ pravenent attein ts ...:-.au, pratiquem ent la celles avec altrations
1/ A ltration s chronosoriciues chcc
: gravement a ttein ts
V o ici l'o b s e r v a tio n prem ire qui nous .. ..... : la v o ie des a lt r a tio n s chromo
son iq u es : sur une f i l l e t t e ne avec ces :1e m a tio n s m u ltip le s ( v . i .
observation 4)non rattach ab lcs aucur.
ru, la cu ltu re des leu cocytes nou
a r v l n i p o ly p lo d ie , n i aneuplod : .. r..-;:
a lt r a tio n s chromosomiques
trs graves, qu'on retrouve d 'a ille u r '
.. c u ltu re des le u c o c y te s de la m re.
Nous avens alors r e c u e illi le sang de .
. ersennes :
- un lo t de 6 personnes a tte in te s d \ zones d'pandage pour conparer leurs
ant vcu de 2 3 ans dans les . j ceux de 2 autres lo ts ;
- un lo t de 5 nordvietnaniens norme - un lo t de 5 sudvietnaniens normaux
Ces 16 personnes ont t tu d i e s soi:;; : : : ..u p o in t de vue des an tcd en ts
hm atolcgique , m tabolique, mdicament :: rccntpenclogique , pour exclure
toute autre cause d'a ltra tio n chromes
.
V oici le compte-rendu gnral de la rcc.
j anom alies chromosomiques :
MLatchuodlteusr ed 'dexuamsaenng :p rip h riq u e a t : .
. r. la m icrotech n iq u e de L ejeu n e.
CInocluchb aictiinone : 07,204h%. L37es mC.itoBsleoscagoent dest : . ;::i::c:.cstadpuhapsce taitvecg rdoessilsasem en t
(x 100). Toute anonalic est repre et
par deux sp c ia liste s. Les
anom alies so n t comptes e t p h otograp h i: ' cour. immersion (x 1000). Les tu d es
caryotyp iq u es ont t f a it e s sur document::; photographiques. Pour chaque m alade,
donc le d ia g n o s tic e s t com pltem ent c a c h , c:-. : compt 100 m ito se s e t a n a ly s
300 c e l l u l e s . 1600 c e llu le s des tm oins . : -i a n a ly s e s.
Les caryotypes sont dresss suivant la
1.. .;: ion de Denver (I 9 6 0 ). Les
anom alies sont cla sses en anom alies chro cuti J 1..eues et anom alies chromosomiques.
Sont com ptes a u ssi corne ca ssu r e s chrc:v :... i : le s im ages en r in g , le s
d icen triq u es, les fragments et le s trans i c c . o r s . Les anom alies ; ring,
ch an ge, tr a n slo c a tio n sont m u ltip li e s par deux. Mous ne m entionnons pas le s
anom alies su sp ectes comme le s fu sio n s tlcm ricpuos ou le s im ages non
iden tifiab les.
VRtaousixcuildtal'eatssnormasluielsta dtse 1: ,1s4ur po1u1r00 1c00e l lcuellel us l e ;. so;: p- eur: d1e5s00 tcme loliunlse, s ndouess rtemleovionnss, un
i l n 'e x is t e aucune cassure chromosomique et set; 1m en t 0 ,4 pour 100 c e llu le s de
cassures chromatidiennos ; rcur 1600 c e llu le s des victim es de l'pandage, nous
comptons un taux d ' anom alies do 5 ,8 8 pour 100 c e l l u l e s . La d iff r e n c e du taux
d'anom alies chez le s tmoins et chez le s victim es des pandages a t trouve
t r s s i g n i f i c a t i v e , t ^1 2,33 avec p ( 0 , 0 l ( c f . tab leau I I )
I. 0 0
2 ) an om alies chromosomiques du type scr..--.u avec m alform ations c o n g n ita le s Les anom alies chromosomiques r e l v e n t du type connu sous le nom de T risom ie 21. En p lu s de c e t t e tr is o n ie , i l e x is t e encore des a lt r a tio n s s tr u c tu r a le s a t t e i gnant le tau x de 1 1 , 66% pour la prem ire o b se r v a tio n e t de 19% pour la 2me ob servation . Pnm i ces a lt r a tio n s, la cassure chromosomique a t de 3,33 pour 100 c e llu le s dans le s 2 c a s, ce qui e s t , comme nous le sa v o n s, un sig n e tr s sil r96d2V'a ltWorn<a*t iAonn sOyci hrnormCohsooumiSqhuienst? dT'atpicrtsf''D* ufbiinncin (1) (1 9 6 2 ), Bender e t Gooch (2 )
i
Examen neuropsychinus : (3 Novembre 1970) par le Dr DANG DINH HUAM.
Retard de cr o issa n c e (81 en 34 n o i s ) . M alform ations du m a ssif c r a n io -fa c ia l :
crne la rg i en a rrire, bosses p a rita les prom inentes, fon tan elle bregmatique
en core e x is ta n te 3 ',/> m ois.
Bras e t d o ig ts rela tiv em en t c o u r ts , su rto u t le 5ma d o ig t des deux c t s .
Hypotonie m usculaire trs prononce : peut toucher sa t te avec ses p ied s. L axit
exagre des a rticu la tio n s : on peut tendra les pieds jusqu' fa ire toucher
la crte tib ia le avec le s o r t e ils . Strabism e interne gauche. Mouvements
Anhuyosrtpiazogoimnnttoaddl eeesnv
uheso'rapipzspoynuc htyaai qunuxt
e
vl ee:
r
srl oentlaagr dddur goliitnte..r
le al,
peut marcher seule : fa it des pas degr prononc d'oligcphrnie.
en
Excute avec lenteur certains ordres sim ples et h ab itu els. : ouvrir la bouche,
t ir e r la langue, le v e r le s b ra s, e t c . . . m ais no peut ex cu ter un ordre p lu s
com pliqu oomne tendre un o b jet sa m re. Tendance aux mouvements d 'im ita tio n
et la persvration. Facult de langage extrmement lim ite.
cChurlotmuroesomdeiqs uleysm:ph1o9c2yte( sc f .(DrtabBAleCaHu UIOI CI ) TUYEM) : triso m ie 21. A lt r a tio n s
3) M alformations con gn itales m u ltip les avec a ltra tio n s chromosomiques sur l'en fan t et sur la mre
L 'observation suivante est extrmement in tressan te : une f ille t t e ge de 17 m ois e s t p orteuse de n a fo rm a tien s m u ltip le s : b o sses fr o n ta le s a ccen tu es ms paptlautleo, cpciiepditvaal,lg ur st,r ocrist seeiml esunrtnubmilartairrae l edt eesn csaynnaudxa cltayclriycm aov-neacsalue x 5, nepooucret eeinl gau ch e. La c u ltu r e d es le u c o c y te s nous a r v l des a lt r a tio n s str u c tu r a le s im portantes qu'on retrouve sur 1 a mre, mais non sur le frre e t la soeur de l'en fan t qui sont ns avant l'pandage et et qui ont toujours vcu loin de cette zone.
V==I J=3*C=L=V==u L=I =L =U*=^* .M. a. lform ation s m u_ ltip .le s e t an om a. l<ies ch. rom osomiques L 'en fa n t HOANG THI H . .. , de sex e fm in in e t ge de 17 m ois, a t exam ine le 20 Octobre 1970 pour dform ations m u ltip les : bosses fron tales exagres, m plat o c c ip it a l, m alform ation des p a v illo n s ; aux 2 p ou ces, la 2me phalange e st a p la tie en sp a tu le, le s pieds sont en valgus avec des o r te ils relativem ent lo n g s, le 2me o r t e il cou rt e t le 5ne o r t e il gauche p a is s i e t b ifid e . L 'a p p a r itio n d'une d a c r y o c y stito suppure 15 jo u rs e t 3 m ois aprs la n aissan ce a permis de' dcouvrir encore un rtrcissem en t co n g n ita l b ila t r a l des canaux lacrymo-nasaux.
A n tcdents : La mre ge de 33 ans e s t m arie jeune ?. 19 ans: e l l e a eu ,
a v a n t, 2 en fa n ts normaux e t b ie n p o rta n ts : un garon a ctu ellem en t g de
15 ans e t une f i l l e ge de 17 a n s. E lle n vcu pendant un an dans une zone
fsor uo mn tiiser etoudet dla'abporrodvinceundepaQnUdANaGge TRspIor(aaudiqnuoerd ddee dCAfMo lLiaOn) t s: , cuent et e f orisgiotnousa lets
deux mois environ, mais ds la seconde m oiti de l'an n e, l'pfndagc s 'e s t
in t e n s if i au rythme de I 3 pandages par jo u r. E lle a e tc directem en t a tte in te
par l'pandage deux f o is , avec la s symptmes d 'ir r ita tio n ocu lo-n asale dj
s ig n a l s ; e l l e a n o t mme la p erte d'une p a r tie de sa ch ev elu re aprs chaque
Ea tltlee innt'ae . pEaslleeu bduev ariut bdeolel'eaauu codue rssoudercesa d3emlae grrgoisosne sds eu.rant to u te l'a n n e .
^
Dermatoglyphes : rien d'anormal
13786
m d io g ra p h ic du pied gauche (Dr HOANG SU) : 6me o r t e i l surnum raire e t en
syndactylie avec le 5mc.
Examen neu rologiq u e (Dr NGUYEN UOC ANH) : 17 m o is, le retard du dveloppem ent
psychom oteur e s t c o n sid r a b le . Lger p t o s is . L in it a t io n .du regard v ers le haut
avec tendance l'a sp e c t d it on "coucher de s o le il" .
5
Observation 2
naasascttassa
:
M icrocphalie
avec
tat
dcrbr
at
trisom ie
21
L 'en fan t NGUYEN THI T . .. de sexe fm in in , g de 10 m ois, p rsen te une n icrccp h alic avec, depuis sa naissance dos accs de contracture en ex ten sion .
pendant 2 n o is , do Mars 1969 Mai 1969 dans une rgion montagneuse de la province de Cuang Tri-Thua Thicn qui a t soumise des pandages q u otid ien s par l'a v ia t io n a m rica in e. Un m atin , 9 h eu res, e l l e fu t le tn o in d'un pandage d ir e c t sur sa r g io n . Au moment o un b r o u illa r d blanc tom bait sur le s arbres, e lle r essen tit des ir r ita tio n s dans les yeux et dans le nez, avec vdievse lalrams soiiteumdeen.ts Ceets rsyhminpotrmrhese diimn tiennusersent: de al lnes slae msoiitr e voemt ier l leet rsee s tsreonutviat bunieen portan te 3 A jo u rs a p rs. La rgion o e l l e h a b ita it a v a it t d j soum ise udnevipnetndjoauger nianltiee nr .s ifE ldlaepsueis s e3r v a4it c doeis ,l 'meaauis de plaa rstoirurdcee cqeuimat taiint-lp,rsl'dpeansdaage m aison, mais ne touchait pas aux tubercules de la rgion. En Mai 1969, e l l e s 'e n f u it au Nord Vietnam e t le 9 Dcembre 1969, accoucha < avant .terme d'une enfant pesant 2,300 kg la n aissan ce. A l'exam en, l'e n fa n t de saxe fm inin ge do 10 mois prsente une m icrocp h alie typique, un fron t court at des o r e ille s im plantes normalement, n a is avec une conque hypertrophie e t un conduit a u d itif externe p lu tt la r g e . Main gauche : epnli ppoaslimtiaoinre t'trasunrsv elersse dueunxiqmu ea,inbs o(uicnlteesr md igdiitaairlees ennotrrem alelesc, entrtrirea ddeiu sla amx iaainl e t la position T); Examen neurologiq u e (25 Octobre 1970) par le Dr NGUYEN QUOC AN1I. M icrocp h alie m anifeste. A ttitude de dcrbration : op istoth on os, extension des 4 membres, membres in frieu rs en cisea u x . A c tiv it spontane et r a c tiv it presque n u lle s. Vie uniquement v g ta tiv e , d 'a ille u r s mal assure : resp ira tio n bruyante avec tira g e su s-ste r n a l. Pas do sig n es typiques do la m aladie de Dcwn.
Q iltu re des le u c o c y te s (Dr BACH QUOC TUYEN) pendant 72 heures su iv a n t la technique de L ejeune. T risom ie 21 c a r a c t r is tiq u e avec mosaque 46,47 prdominance 4 7 .
Anomalies chromosomiques : 11,66% das c e llu le s ( c f . tableau III)
O==b=s"ervat-i=o*n=" II I T risom ie 21 typique chez une en fan^t de 3 ans nee dans ,ta zone d'eantage
L 'en fa n t HOANG THI TKU T H ... 3 ans a t exam ine par nous le 2 Novembre 1970 : son p r o f il e s t ty p iq u e d'une tr iso m ie 21 (p ica n th u s b ila t r a l, cartem ent d es yeux, crasement de la racine du nez, bouche entr'ou verte en V in vers, langue en s a illie hors de la bouche). Pre n en 1922, mre, en 1930 : le pre e s t l'a in d'une lig n e de 5 garons e t 4Pafs i ldl'easlt,e rlaa tiaonres de as tns aale ssoeducrrmcaatdcegtlytep hde'su,nesaulifg nune pdlei p2aflmi lal eirse. tra n sv erse unique L 'egxaaumchene arvevc lele untreirlaadxiiutds alixg aiaml eenntatir1e ;avleesc hb yopuoclteosn ide-img iutsacluelsa irseen tt r n 3ormmaarlqeus.e aux membres. P.etard psychomoteur im portant. Phonation d fectu eu se. L'anamnse rv le que le s parents ont vcu dans une .zone de la province de OdUeAdTG fNoAlMia ndets 1p96r4esque19q70u.o tCideiteten sr, dgeio n196a6 t 1s9o7u0m:isep ersodnasn elpleamndeangt,es e cl ol en tinn'ua s pas accus de syndrome ccu la -n a sa l par attaque d ir e c te , mais e lle s 'e s t nourrie de tu b ercu les d te r r s ap rs chaqua pandage e t mme de r iz a t t e in t par l e s d fo lia n ts pendant une priode assez longue : 4 ans. L'enfant e st ne dans c e tte zone le 7 Dcembre 1967.
/
C ulture das leu c o c y te s (Dr BACH QUOC TUYEN) Nombreuses anom alies chromosomiques : 13 % ( c f . Tableau I I I ) Lmaiqcuuesltu:re7,3d3e%s l(ecufc. o Tc yatbelseaude IIlaI) mre r v le le s mmes a lt r a tio n s chromoso eLte vcaivraynottyploe ind".defr lar e zoent edde 'lpaansdoaeuger edes t c acbttscoluemnefantn tn, onrmsala. vant l'p andage
DISCUSSION
Nous avons rc'andre ces 4 q u estio n s : o1c. uLlae3ir eds fo? lia n ts an l'e s p c e le 2 , 4 , 5~T p e u v a n t-ils provoquer des l s io n s 2 . ^.es d fo lia n ts p e u v e n t-ils provoquer un syndrome d 'a sth n ie prolonge ? 3. Les d folian ts p eu ven t-ils provoquer des anomalies congnitales ? 4 . Les ' -fo lia n ts p e u v e n t-ils :-ovoq u cr des a lt r a tio n s chromosomiques ?
DEFOLIANTS ET LESIONS OCULAIRES C liniquem ent le s l s io n s du segment a n t r ie u r <^e l'o e -il ( l s io n s cern een n es) sont con states sur la s personnes exam ines dnns une proportion anormalement leve ; toutes ces dernires ont signal la tableau cculo -nasal des premires hdauaexudriensfosdltieai lnllt'cstpieacnonsnddaoegcneu.slaeCsi.r-mesnusar csuelasr clleossnijoaonnnsicmtpiavuaexr.aeitsEsxelpantrciomtrernnetaad,leumneoseunsatu, xavsuognrosult'ptoraoelceiltdtadses la p in s, l'u n da nous (4) a reproduit la s l sio n s c lin iq u e s observes sur l'homme, par i n s t i l l o t i ' a s de S a lo st ('KHange de 2,4-D e t de 2 ,4 ,5 -T ) e t de Tordon 22 K (4 , amine 3 ,5 ,6 acide p ic o lin ic u e ) :
a) le S e le s t provoque sur la corne e t la c o n jo n ctiv e des b r lu res du 2mc e t du 3mc degr qui peuvent g u rir : n a is e l l e s peuvent a u ssi provoquer des b r lu res du 3me e t du 4ma degr ( c la s s if ic a t io n de P c lia k ) a v e c , comme consquences des o p a c ific a tio n s de 1a. co rn e, des p e r fo r a tio n s corncennes ou des atrophies oculaires.
b) Le Tordon 22 X provoque sur la corna e t la c o n jo n c tiv e du la p in des b r lu res du 2me e t du 3ne degr de moindre g r a v it mais sur une p lu s large tendue.
DEFOLIANTS ET SYNDROME ASTHENIQUE
Ce syndrome asth n iq u e b iza rre s i prolong qui nous a ta n t in t r ig u s , p e u t - il
tr e a ttrib u l'u sa g e da d fo lia n ts ?
Rappelons d'abord que c e tte asth n ie a t sign ale sur le s tra v a ille u r s des
u sin e s fab riq u an t le 2 ,4 ,5 -T (5) . Vers 1960, la Compagnie Dow a t o b lig e de
fermer ses su ccu rsales Michigan parce que 60 ouvriers c o n ta c t r e n t une maladie
ca ra ctrise par des ruptions cutanes et des dsordres du systme nerveux
Cc eonmtpraaglnie: ?f1a Ntiegwu eJ erchseryonpiqrusee, nltars seinttu dlee s emt ardnasp rseysmsipotnm. eLs,esmoauisv rcieert tse da'usnthenauiatre
s'o b serv a it encore chez qu?Iques-uns 6 ans aprs. Depuis I960, le s mdecins de
la RFA ont s ig n a l la mme m aladie chez des o u v riers tr a v a illa n t le 2 ,4 ,5 T
avec a tte in te du f o ie , dsordres mentaux e t nerveux, d p ro ssi* n ,p erte du poids
et de l'a o p c tit et impuissance sex u elle.
Rappelons la m oiti
encore que la dose l t h a le LD50 des rats d'exprim entation) est
?.at (dose d'environ
en kg/poids 400 mg pour
ca le
p
able 2 ,4 ,5
de -T
.
tu-et
r ot*
D'aprs D r ill et Hiratzlca ( 6) (1953), l'a b so rp tio n de fo rtes doses de oe -1.0 1
produit provoque chez le chien des lsio n s m usculaires.
L'ous 7 'm s con clu re : p lu t Tt qu'une : le n to de l ' or ran i sme par l ' afcserre ion C2 h,4e,z5 -dTe pc orisvenmaanltades:s, oipr.--1apdeuagt eds ctec nc tteirru retrouver la maladie causale : ce sont culture des leucocytes Ccf. table \ 11).
DFOLIAHTS ET A.CFDT5 TPXATCUr.tTb.E
I) 2 ,4 .5 - T ET ?Z0XIV,?.F
Les d fo lia n ts e t herbicides u tilis s
l 'a tte n tio n du r .ide r a d ic a l e s t attire---
Spandu, d ' aprs Jacicie V crro tt (7) au p.<,
moins sur 5 m illion s d 'acres en 9 ans.
Le 2 ,4 ,5 -T ou '.de a c tiq u e 2 ,A ,5 -c r ic !
auquel i l est trs souvent associ par e
pLbpeaalursepptrateelremst
idpaeurc
tt
irtrveoamepl esppso.od,reut. c
os deux produit
c1l o''nhanvuueinlets-unDrvailenaspseol
. e
suf fLteseietsl ls:
l
;
B ionctics Recenrch Labcrotcries (3 ). "
Le a1u!x?
7
,4 ,5 -1 sio? u/krsi s
,eIfM?Ls*!'.itWVdCtel*nI?in' vf1.O. Cf1OV<"*.Sr
qu'aux h yb rid es RLAF
>?>?\I"nU'*.\ 1C..-~ d
iv'o i<_? 21 e su
or
1?*
do
ale ,'t 112
a | n:.
in j e c t io n s . L'a d m in istra tio n ''a la drop
dans la plu p art des cas (du tir '.- jou r ar
9 jo u r s , dans eue lo u es ces (du mx au 1:
au i 4i;mc jou r) dans en c a s . La 'T-'.r. ^ev.s-
peur la voie rala,
' la' . c l .
-ien m assive, une in to x ica tio n de b oisson contenant le e: nsttriagmn earte unpeeramsetthtanntie dpe ro lo n g e. .t tio n s c hror.o sotr.ique s la
-'-V iecn rr so n t v a r i s : mais
t
>t ic
ul m
io ill
r io
s n
u s
r
le de
2,4,5liv r e s
T qui au
a
t
...::yde ce d iff r e n c ie du 2 ,4-D de chlore supplm entaire : la da2n,4s-0dees t foduu2ju,i4n,s5 -aTyasnetnpt oulers
r du 2 ,4 ,5 -T e st c e lu i de s rsultats : s ?T,6 aux o se s de 4 6 ,6 e t ':< ; i l a t a u ssi ne!ni ni s t r ut aux AKA s o u r is . de mme
la voie sous-cuta.ne, en effectu e pendant 3 jours . ur de La p o st tic r .) pendant ; s I; : 5 jo u rs (du IQno u t i l i s e comme v h ic u le le DMSO :
A l'ex cep tio n de la dose la plus la s s a (7 !;:
cu tan e) to u tes le s a u tres dose;,- que l l e
une in c id e n c e l l -r'C- d-; fo e tu s que m aux,
est trs fa ib le s.
frquente., 7i la dose La tau:: d ' eppcvi cion
d.a des
!
r1Se i
m.a/k n s h;,
f a i t e p eu rles scucnes AKl e t le s so u r is 3 :
La m o r ta lit fc o tr .le e s t nuon e n t e '.ans i.
punene ddanoste
3 p l u
9 s
jfoauibrsle,_(AC-';! 4
nq/hgla pasor uvroisie
e. .
cutane).
Udense dtousdees dsoi.m2i1la,5ir ee t a46t,4 mf ai/tkeg esnur sulespernast' !.. par la v o ie o v a le , du 6mc jou r au 15m jeu.: taux e x c e s s if b', m o r ta lit r.tnl-e ut une i:. alevsec sular vpivluasn tcso. uFrtaeit dduricnee doecs rineijaeacrtniuoen, s ,uv. tr o is fo is plus grande chez le s .imnux d
Comme le 2 ,4 ,5 - 1 e s t m lang des impuret;:
ces d e r n i r e s . 4 La C onfrence EDA (24 Tv;-..
dose de foetale 1 ' in cid e
d io a nce
xines t de dus
de 9,! /'-g /k g /jo u
82% e t le s anomalies a
anto dnel
r i
c,5rsu(9rr)
le**s1 .
D'aucre p a rt, sur la souris FDA S tu d io s.
a wv eicr .s l- e' .J e"c,s4t c, 5r
T purifi, cet r e t sur 'e h ans'.-
; aux so u r is 3L6 par v o ie cou s: in voie u tilis e , ort provoqu --.ion d'une d iv isio n palatine e l l e e s t .. .ulle es d oses p lu s
est aussi lev, exception ait 46,4 mq/kg par voie o r a le . . groupes recev a n t I 13 mg/kq avant c e t t e meme d o se , mais et 2! ,5 mg/kg pe.r v o ie so u s-
r;ruche Spraguo-D aw ley. Avec
-rtl.ae
50g%leesvdt ae et
imodniee,lt,rouneiltfcanacodpbm.fsceiinrnvinsstr
uchne
s ez
' es fa ib le dose (4 ,6 mg/kg) et
j;:cc des foetu s anormaux a t
ace. que chez le s tm oins.
a les d io x in e s, on a tudi au ssi
70) on a trouve qu'avec 1
ter3 32"?
a
a A
g e sta tio n , la dose de
la m ortalit 0 ,5 j<- g /k g ,
13789
tratognes ont t confirmes
r le s MIEKi S tu d io s e t le s
II) VOIE DE CONTAMINATION ET DOS!' l'INT!'..'
Far q u elle v o ie a pu se fa ir e la ccntamii-. q u elle dose le s e ffe ts tratognes pouver. . Il ne semble pas que ce so it par m v oie re sp ir a to ir e ) ; i l semble p lu t t que par les pandages continus qui s o it lcvhi. D'autre part, i l faut sign aler que le 2,4, un c e r ta in temps : M ille r e t Bar*g (11) af : par acre, i l peut p ersister pendant 4 de 6 m ois.
'.MOCENE
a la femme p esta n te e t ..lifester ? .j directe (voie lacrym o-nasale,
l 'eau des sources pollue .le l'in t o x ic a t io n . -.ut p e r s is te r dans le s o l pendant . qu' la dose de 0,25 8 liv ra s j ; De Rese (12) donne un maximum
W hitesidc (13) a c a lc u l qu'en tenant ccm; Vietnam, une vietnam ienne de 40 kg buvant . 120 mg de 2 ,4 ,5 -T par jou r s o it 3 mg par k. d io x in es, ce qui e s t la r g le , le taux de microgramme par jo u r. Une t e l l - dose p e u t-e lle tr e tratogn e ? tra n sp o ser le s d oses ob serv es chez le s a; dHeeulraeurseamceenhtuml'eaixnpe r?.iecnoclel dedesla anthimalaiudxc.m Aidv. la plus basse a t estim e 0 ,5 mq/Kg/jc.. t estim e :
doses employes par acre au .ces d'eau contamine, absorbe :>oids. Avec le 2,4,5-T pollu de lues absorbes e st de 1/10 de . a di t'exqpu'ri ilmeesnttadtiiofnf i c i l1e'hodme me, ormis de comparer la s e n s ib ilit . thalidom idc, la dose tratogne . our la mme a c tio n , c e t t e d ose a
30 mg chez la so u ris 50 mg chez le rat
315000
mg mg
chez chez
le le
chien hamster
..ter) (14)
On peut donc dire" que la femme e s t s e n s ih i .'- .f f a t tra to g n e :
60 fo is p lu s que la s.
100 200
fo is fo is
plus plus
que que
le le
t
700 fo is plus que lu :
... r
En supposant que la femme s o it a u ssi sa n si.
2,4,5-T qu' la ThalidomJdc
(ce qui e s t tr s p o s s ib le ) , on peut chercha. .. c a lc u le r la dose minimal-:
tra to g n e chez la femme sach an t que c e lle -.: i r.t s e n s ib le c e t e f f e t 100
f e i s p lu s que le rat : en nous rep ortan t r.:..: e x p rien ces sur le rat ce la
souche Sprague-Dovlcy, la dose minimale tratogne
dosa chez
tratogne I 1-a femme sera :
; .,
. .
ajs
faible l'o r d r e
tant de de 4 ,6
4 _
,
6 ...
n .,
g
/
k
g,,,
la
To = 'vVf6 mR'kR-
D' aprs W h itesid c, la dose absorbe par une tnamicnne do 40 kg e , bov.ant
de l'ea u p ollue e st de 3 mg/kg, c 'e s t d. : fo is suprieure la dose prsume
t r a to g n e . S i le s pandages so n t quotidien. -r une r g io n , le s chances pour
une jeu n e femme p esta n te de co n cev o ir un ,t\-. _ ..; anormal or.t extrmement f o r t e s .
dSuopitpoesnonsabmsoaribnetrenpanart qjeuuer l 'Ie/1f f0e tde tmriacrtcoggranme:-..s: o pitar dul'eaauux pd oiollxuin ee s (W: choimtomseidlea); femme
ce rin
mdicament s ` et f
i
s n
'accu ir a it
m ule par
rait atte
dans indre
1
'o le
r
ganism se u il
e t
comme ratog
to ne
u
s ;
les hydrccarbones chloe t comme le s pandages
sont q u o tid ien s, le s chances pour e l l e de con cevoir un enfant anormal sent
Dgoanlcempoeunrt qtrues laf odrot sees . de d r fe lia n t s o it trv.-..-,n c, i l fa u t q u 'e lle a tte ig n e un
s e u il qui n'-a pu tr e p r c is comme avec la '.iidom ide, m ais ce s e u il peut
tre franchi :
a) s o it par s e n s i b i l i t marque de l'o rg a n ism e humain au 2 ,4 ,5 -T ou -aux
dioxines
bc)) ss oo iitt ppaarr uactciul ims autlai otinon dde adnsosel 'omragassniivsem e:.
1 3 * 7 ^ 0
I I I ) VALEUR DES EXPERIENCES ANIMALES I. Une iiss plus grosses d if f ic u lt s d'apprd.:. v a ria b le d'une espce l'a u tr e v is vi_. exemple, la thnlidcr*ido dangereuse peur ' . echspez clees, raaut. mNoinasnmsuoirns,t r soiis ,I'eixlpf auritm eluntia:
' LES TESTS TE3AT0GENES;cn rsidu dans la s e n s ib ilit -n mdicament tratogne : par 1 :epsint pneo spitriovveoqusue r apucluuns iee umraslform ation dur une axtrne a tten tio n ,
su rto u t s i ces esp ces se n t des rongeur.-: , : on s a it q u 'il n 'o x is te pas de
d iff r e n c e s fondam entales en tre le s racL . ..s de l'em bryon humain e t c e lu i
des rongeurs (15).
IV) ACTION FOETICIDE CHEZ LA FEMME I c i, l'p reu ve clin iq u e peut tre d cisiv,. . - e a pu r elev er :
1) une action abortive : d e l' in terrr.ratci: vos victim es de 1 ' pandage, nous
avens dgage ries f a it s a ssez trou b lan ts ; r a t t ir e r l'a tte n tio n m dicale sur
la as/-uaspcreps t ilbeislitpadnudamgeas tdrainesl glesn jtoiquures cI.... .Aaii vauexn td, iflo liya natsnu :un nombre an om al
dd''aAvNorTtReAmCHent(5smhoumzaoinnse ),: psuarr e73xemfemplme,esdaayncs.;.
; d i s t r ic t s du LONG DIEU e t r.anifost des signes d 'a ttein te oculo-
n c sa le , i l y a eu 22 avortem ents (.'panda:: _ i mois de Mai 1966).
b / on a observ aussi des avortements
:s animaux dom estiques :
- dans lu d is t r i c t d'AN UCVIA (5ine z. aprs l 'pandage (Mars 1966) 7 vaches ont avort (<lans ce mme des troc.-: . a s ig n a l a u ssi que truites les poules aprs l ' pandage ont cess de ; u)
- dans le s d is t r ic t s de LONG DIKK et r! AU TRACH, aprs l'pancage du mois de Mai 1966, 63 b u fflon n es e t 92 tr u ie s ou a v o r t .
2) une frquence accrue des avortem ents r.: : i ras : dans le s zones d*pandage, . i l a t sig n a l une frquence anormale d' . zzenents m o la ires . Ce f a i t d o it nous in q u i te r s i l'o n so. r a p p e lle qiu Lu p la cen ta de t r ip lo d ie montre mme m acroscopiquem ent, dans la m a jo rit d u as, un a sp ect v s ic u la ir e , su b n lairc, in t r e ssa n t une p a r tie eu la z: i i t des v i l l o s i t s (T h ilip p e e t Boue) (1 6 ). Une a b erra tio n chromcsomiqu par in g e s tio n de 2,A ,5-T au dbut de la g e s ta tio n reu t tr e 1 1c r ig i du ces avr.rtem.onts m la ir e s.
DEFOLIANTS ET TRISOMIE 21*12 Nous avons observ deux cas de triso m ie 21 sur 2 sudvietna.m ienrr s ayant vcu dans le'-.zo n es d'pandage : l 'une d 'e lle s a mme a.ccus des sig n e s immdiats d 'agression oculo-nnsale la su ite de l'un Je ces pandages. Odnes s achirtomquoesomlaesThroismomoloiegu2e1s, e esrt relua r coqnusiqauentce adtt'ruinbeu eerreauur vdieainlslislsae msepnatramtiaotner n e l. Mais c e tte trisom ie peut se v o ira u ssi dans le s s u ite s de rad iation ou de p rise de mdicaments toxiques et l'on sa it nue le produit n ocif peut agir Vsuoric1i 'olersgananegomnalsiees enqutree nolaus 2amvoonse t c olan s7tamtee sserssuorinel'edxeamlaen gdees tantoios ntr. isom iq u es :
1) la je u n e sse de la. mre dans le 1er cas : on s a i t que la tr iso m ie 21 su r vien t surtout chez les derniers-ns d'une fam ille nombreuse, par consquent le plus souvent chez la mre ge. D'aprs Carter (17) et Penrose (! ), Turpin e t Lejeune (19) c e u x -c i estim en t qu'avant 1 T.ae de 30 a n s, le risq u e e s t de ` `-rr1 ' ordre de 1/2000 ; ?. 35 ans, i l s ' l v e , A/ioOO pour a tte in d r e une valeu r de l'o r d r e de 2% p ass l' g e de A5 ans. Les Jeux mres de nos trisom iq u es ont resp ectiv em en t, au moment de la n a issa n ce de Leur en fa n t :22 ans (Ob et 37 ans (O bservation 3).
2) La triso m ie 21 dans le prem ier cas n 'e s t pas pure : a l i e e s t encore. .associe une m icrocphalie
dleus3s ) md oaiigLntessa, d2; anstresiuslola,ms ilqe'ueurexsl i cneapsap.lmrasieren tetnratnsnvucu jea Iutnriq eueiona d tes dcoo.rns taatotp .lysuphr ei s'unsue r
de 4m) lraes.troOpn sgraaint dqe uefrlqauetnr icseo ndiea c e21t t esu trrviiseunmt iuavesuc r uunne e frsiqufaeinbclee* s iptoupuelaetinotnre 1/600 et 1/700 n a issa n ces, a lo rs que sur .notre fa ib le lo t , e lle a t de 2/4 naissances.
5) e n fin , ce qui permet .'.'affirm er que ces tr iso m ie s 21 r e l v e n t d'une in to x ica tio n mdicamenteuse, c 'c s t qu'a ct de co tte trisom ie, nous avons relev des anom alies chromosomiques stru ctu ra les d 'une haute gravit :
-
chez chez
la la
prem ire seconde
e
enf nfa
ant nt,
,
i
i l
l
y
y
a
' 3
3,3,33/3lG/IOCOc
c e
e llu l llu le
e s
s
de de
c
cassu assur
r e
e s
s
ch rom osom iq u es. chromosomiques
C 'e s t d ir e prs de 6 f o is de p lu s que crhea le s su r v iv a n ts d'H iroshim a (0,55/100 c e llu le s de enssure i hromosi-aiique, d'aprs Jlloon e t Al (2 0 ).
DEFOLIANTS ET AUTRES 'lALFQRldATTONE CONGENITALES Lclah'croorbmysmoesraovlm,aetmsioenqmub4'roenrs) vresutlrerouulv'neeex idesn'tafeainlnlcteeuardsses omscuiureltliap lemdsesrae na no(1mc3%naalileciehs sez(csrtlr'eunnceft,aunrcatanleeastl d7,o3s3% chez la mre) C eci nous penr.ee de supposer nue la mre et l'e n fa n t probablement ont t soum ises de m u ltip les a g ressio n s par des su b stan ces chim iques au moment de la g e s ta tio n , l'em bryon s ' t a n t r v l comme p lu s s e n s ib le que l 'adulte aux a ltra tio n s chromosomiques.
DEFOLIANTS ET ALTERATIONS CHROMOSOMIQUES123 On s a it que la s su b stan ces chim iques peuvent provoquer d e sa b e r r a tie n s chromosomi qchureosm. oDsoamrliiqnuqetsorp. roe vt oqKueleles r pa(2r1)le s(9m4o7u)taordnets, le sl'apzroemt eiesrus r dT crnr irtieslceas n tailat, rcaetiqounis ou v rit la v oie aux tudes sur le s a lt r a tio n s chromosom.ioues provoques par le s mdicaments anticancreux (22,23,24) et par les substances chimiques dont la lis t e a t tn'-l.ie par Ftahl et Luciani (25) . Puis ce fut la tranclie de la th alid em id e e t le s r v la tio n s sur Le LSD 25 ( 2 6 ,2 7 ,2 9 ).
Nous croyons que nous soi-m.es le s prem iers s ig n a le r le s a b erra tio n s chronosoniqu' par la s d.:fc il :a ts . Nous pouvons so u ten ir que l'a lt r a tio n des chromosomes a jou un rle n faste au cours de la g e s ta tio n :
1) ce sont le s a lt r a tio n s chromosomiques qui ont t responsables des avorte mr eepnrtsis mrucletmipmleesnt chpeazr llae s feamumtee e t? lfr'aannima iasl, (Bdo'aupe rest dluosu)tra(v3a0u1x, dPoh iCliaprpre (2e t9 )B, oue (1 6 ), Roux (3 1 ).
2) ce sont le s a ltra tio n s chromosomiques de l'cnb.ryon au dbut de son develop pensent qui ont cr le s anom alies co n g n ita le s, du type rapport dans l'observation 4.
3) Les d -a lin n ts (du type 2 ,4 ,5-T) ou d io x in es) d 'a lte r a tio n s chromosomiques e t de tratognse , e t
son ces
t
f
in ai
du ts
cteu ont
r
st
la
amf opilsement
prouvs par l'exprim entation et nos observations clin iq u es.
w g* sm
0w
Ouol sera l'a v en ir d'une population dent la v ie a t remani c par de te ls
b ou leversem en ts c o lo g iq u e s, qui n'oparm ent cerne n as, to u t cnmme dans la
gu erre atom ique, le p atrim oin e ehrcm cscniuue humain ? T.;- r nn r r
n t* t* i *-t 1
3
- i: -
..
le s leu cm ies e t 12s nonstruosLto s (13) sero n t certain em en t le s d e n ie r s
le s p lu s graves -. ai: '>. A l'h e u r e a c t u e lle , par 1 ' a lt r a tio n de leu rs
chrcmcso tragique
me :
s. la
i
l p
exista opulati
o
daux n su
r
pv oi vpaulnat etiodn' 'sH
.t.i irosh
so im
n a
hl e
e t
n
t de
partager Nagasak
i
l
e e
t
meme les
sort
v ic tim e s des aor.es d'pandnp.e de d fo lia n ts nu Sud-Vietnam .
En c o n c lu sio n , l'u tilis a tio n m assive et prolonge des d fo lia n ts, en dehors des lsion s o cu laires permanentes peut amener des a it r a tie n s chromosomiques de toute une p op u lation o b lig e de s'a ccro ch er au s o l a n c e str a l, et ccs a lt r a tio n s peuvent provoquer dans sa. descendance des m alform ations c o n g n ita le s dont l'im portance reste p rciser. Dana l 'h is t o ir e abom inable des g u e r r e s n 'a -t-o n *11jam ais vu so r t a u s s i inhumain rserve aux survivants sinon avec la guerre atomique ?
PUFERFMCE5
(1) DUBININ HP l z d An. CCCS 1962, i. : 39 (2) BENDER MA a t GGOCH PC, P roc. n a t. .Va. S ci (U S), 1962, 48 : 522 (3) HONG AN CHI e t CHOU SHING TING, A cc. B io l. cxn . S in ic a , 1964, 9 : 178 (4) DAO XUAN TRA . s 'ons o c u la ir e s ex p rim en ta les avec le S e le s t e t le Tordon
22 K, T ra v a il non p u b li , P ro to co le S annex au rapport. (5) WHITESIDE T. D e fo lia tio n , In ta x t P u b lish er NY 1970 p. 48 ( 6) DRILL e t HIRATZKA, c it s par GKUMMFR G. D sherbants au Vietnam ; VN-Auss.
b . A fr. A s ia t. S o lid a r . b e r lin , I960, p. 55 (7) J a ck ie VEP.RETT, In E ffe c ts o f 2 ,4 ,5 -T on "an and t!ie Environm ent, US Senate
91st C ongress, Washington 1970. p. 104 ( 8 ) RI0NETIC3 RE. LAP. in ouv. c i t p. 407 (9) FDA, tr a v a il non p u b li (10) SPARSCUU C-L, DUNM FL, e t HOUE VK (Dow Chemical C) , Soc. of T c x ic c lc g y
9th Ann. Meet. A tlanta, Georgia 17/3/1970 (11) .MILLER MW e t 3ERG GC, Current R esearch in P e r siste n c e of U erb icid .es, (12) chDE. TROhoSmEaKs RPBuobtl.isGh earz.s, 11994669. 107 : 533
((1134)) WFHAILTTEESRI, DEc i tT. opuavr. EcPiStTEINp. 34. 07E f f e c t s o f 2 ,4 ,5 -T ouv. c i t e p . 406
(15) TUCHMANN DUPLESSIS F . B u ll. Fed. S oc. Gyn. O bst. 1968, 20 : 9
(16) Fui lip p e F., e t HOUE J .E . P resse n J . 1970, 78 : 641
(17) CARTER CO e t EVANS FA Lancet 1961 11 : 783
(18) PENROSE LS Hunan Chromosomal a b n o r m a litie s, S ta p p les P r e ss, London 1961
p. I16
C 9) TURPIN R. e t LEJEUNE J . Les chromosomes hum ains, G a u th ie r -V illa r s , P aris
1955. p. 93
(20) BLOOM AD e t A l. Lancet 1967 II : 802
(21) DARLINGTON et FELLER PC H ered ity , 1947, 1 : 187
(22) CCNF.M PE e t LANSKY GS, B r it. Med. J . 1961, 2 1055
(22) (24) (25)
BELL S . BELL S . STAHL A.
e e
t t e
t
W1.L1OU.LFCEBIAloNSn.I
Pro d, 1 JM
c. Nat. 966, 27 N ile R
A ad. : 771 evue E
Sc rse
i
d
(US) 'H m
1964 atolo
: gi
5 e.
1
, 1
9
195 70,
10
:
17.8
(26) C C E 'jm e t A l. S cien ce (NY) 1967 , 155 : 1417
(27) I.'.diN S. e t EGGZCUE J . S cien ce (NY) 1987, 157 : 313
(23) Hans ZELLWEGER e t A l. L an cet, 1967, II : 1066
(29) CARR DH An. J . O bst. Gyn. 1567, 97 : 233
(30) BOUE JG e t BOUE A. P ressa Md. 1970, 73 : 635
(31) ROUX Ch. P resse md. 1970, 78 : 647
13793
frequences j-V ix.-r m *:S c:; w 1i WJ : c i : v l. : 7L":" GROUF? : LXAIlM
Al-i.EAU II
cv>uo
!1 f.o
: p o m p r? c
. -. rr ..........:
y. : .0 ..--.".V.f*_^,,*
. LO'.-.L-\L1/l L'.'d
: C :
45
;HRCrOLJ.-iU.;
;
47
i
I ZZ/ : T n oin s n crin u x
u**
II
CVUMOXH/J),
Tnoins ayant, vcu . Sud-V etnarr. n a is pas encore victirn s . d'cpandayes
nu
HHOOAANNGG HOANG
T:THHGTI
ALRO.. .
:
00 100 100 100
:2 3 4 1
3 95
10 9966 6 93
48 ^
n r
V ic tin e s. d'Cpandasas
VO THI UANG H.:
:sans sq u elles apparentes
PHAIi XUAN P. HOANG THI L .
100 100 100
36
71 1
12 8
897147
1
IV :V ic tir .e s d '^ p .n d ap es avec
sq u elles irpcrtnntes : iarsatsh n,ie , l s io n s c c u ln i-
TDNFGINAUHNYENTHHOVNIGANTKR0.. .
100 3
100 100
: 33
S 5 8
<*
/
1 2
V Enfants ns de rares victim es d'pandanes
*
<HNDOOGAAUKNY'GGENTTTHHHII IHTHT. U. T:.:
100 100 100
J 4J3<j
0
21 5
93
69 89 2
1
`n
v
EPANDAGE DE 2,4,5 - T AU SUD VIETNAM
PROTOCOLE D'EXAMEN CHIMIQUE
essssssssxasassssssssssssaa
Le 15 J u ille t 1969 9 heures du m atin, tr o is avions C 123 ont rpandu dHUeOs NGto xTHiqUuYe, s Pcrhoivniniqcue esde. suTHr UAla THpIEaNr.tie o c c id e n ta le , du d i s t r i c t de L(ces rp aroledsu,itslgtuomx ieqsu, esarbonret s dfrtur uitiite r3s00 .h. .e)c ta r e s de te r r e s c u ltiv e s Prs de 100 personnes ont t in toxiques avec le s tyr-ptmes : cphale, fi v r e , vomissements. . .
- le s produits toxiq u es, de couleur brune p le, tombent en fin e s g o u ctrlet tes e t recouvrent entirem ent le s f e u ille s e t la su rface do la terre
- nous avons prlev sur les fe u ille s ces go u ttelettes ' des fin s analytiques Divers essa is chimiques ont t effectu s : I . avec le r a c t if au bromure m orcurique (I!)<Br2) : r s u lta t n e a tif ( 2 . avec le r a c tif l'a c id e chromotropique on m ilieu su lfu riq u e : rsu lta t p o sitif (apparition d'une coloration rose v io le tte ). 3. avec le r a c tif au Rhodamine P : r su lta t p o s it if (a p p a ritio n d'une coloration rouge). 4 . - pasurr chcoruomchaetodeeraspihliiec as.u re l cGouches m inces :
- avec le systme de solvan ts : cl lcro fo rn e, acide actique (dans le - rIoanopaourtbn1ta9n:co!s) rferen ce : n. lutyL e s te r du 2,4 D
n . butyl e s te r du 2 ,4 ,5 T - rvlateur : vapeur d ' iode RESULTATS
- apparition de taches v io le tte s - le s c h a n tillo n s et le s su bstan ces de rfren ce ont le mne Rf
(rapport frontal)
CONCLUSIONS Nous basant sur l'a c tio n nocive snr le s arbres c u ltiv s , e t sur le s rsu lta ts des examens de la b o ra to ire, nous concluons qee les produits chim iques rpandus par le s avion s am ricain s sur HUONG THUY so n t le s e ste r s n. b u tylin iq u es du 2,4 D et du 2 ,4 ,5 T.
20 J u ille t J969 L'expert chim iste responsable,
HUYNH VAN BA
HISTORY
C haracteristic D e f in it iv e H isto r y o f exp osu re to a known q u a n tity o f TCDD D e fin ite H isto ry o f exp osu re to a su b sta n ce c o n ta in in g TCDD but quantity unknown. D efin ite H istory of exposure to a substance possibly contain ing contam ination. H isto ry o f p o s s ib le exposure to a su b sta n ce w ith TCDD p r e se n t.
CLIBICAL t
Acne beginning w ith in three months of exposure and no prior history of acne. Acne beginning w ith in s ix months o f exposure and no prior history of acne. Acne beginning w ith in six months of exposure w ith a prior history of acne w ithin the la st ten years. H ep atitis occurring w ithin three months of exposure without other probable etio lo g y . Porphyria Cutania Tarda occurring w ith in three months of exposure w ithout other probable e tio lo g y . Chronic hep atic porphyria occurring w ith in three months of exposure w ithout other probable etio lo g y . P eripheral neuropathy occurring w ith in three months of exposure w ithout other probable e tio lo g y . Acute neuropsychiatrie disorder w ithin 30 days of exposure. Soft tissu e sarcoma Lymphoma G astric carcinoma Cancer of any organ system in the absence of sig n ific a n t confounding carciongenic risk fa cto rs. M ultiple spontaneous abortions in fem ale exposed C ongenital d efects in m u ltip le o ffsp rin g s of male or female exposed w ithout other probable etio lo g y or chromosomal abnorm ality.
Characteristic
M u ltip le spontaneous ab ortion s in fem ale partner o f mala exposed. High l e v e ls o f TCED found in Fat or B lood. Abnormal nerve conduction v e lo c it ie s w ith in three months of exposure without other probable etiology. E levated liv e r enzymes w ithin three months of exposure w ithout other probable etio lo g y .
E levated serirn ch o lestero l or T rig ly cerid es w ith in three months of exposure w ithout other probable etio lo g y . E levated urine Uroporphyrin w ithin three months of exposure without other probable etiology. Abnormal com position of urinary porphyrins w ithin three months of exposure w ithout other probable e tio lo g y . Increased frequency o f breaks and gaps on chromosomal a n a ly sis.
MARVIN A. SCHNEIDERMAN, Ph.D.
As a fu rth er supplem ent to Dr. Schneiderm an's Summary o f testim on y, and by way o f fu rth er d e sc r ip tio n o f h is su b ject m atter, substance of opinion and bases for those op in ion s, P la in tiffs sta te as follow s:
The m u lti-sta g e model of cancer d eriv es from as was stim ulated by the ob servation in humans th at cancer in cid en ce (and m o rta lity ) ra tes increase very rapidly with age. O verall, in a b asically stab le situ a tio n , w ith no important changes in exposure (eith er increases or decreases) the r a te s for (many) ad u lt cancers in crea se w ith about the fou rth to six th power of age. Armitage and D oll in 1961 (P. Armitage and R. D o ll, S toch asic Models fo r C arcinogenesis in P roceedings of the 4th B erkeley Symposium on M athem atical S ta tis tic s and P ro b a b ility , Ed. J. Neyman, V ol. 4, pp. 19-38, U niversity of C alifornia Press, Berkeley, 1961 laid out th is concept in a m athem atical form. Their mathematics is an expression of the concept that a sin g le c e ll becomes m alignant a fte r i t has gone through some f in it e number, say j . , heritab le changes, or step s, the probability of each step being rela ted to a "background" e ffe c t (some of which could c le a r ly be a gen etic p red isp o sitio n ) p lu s an e ffe c t contributed by exposure to some exogenous agent, i . e . some ex tern a l chem ical or p h y sica l agen t. In th e ir form ulation they recognize that not a ll stages or steps need be affected by the external factor or agent.
The m athem atical statem ent of the process takes the form
(a .l + bi.d ) where P = prob ab ility of cancer
e = the nature constant, base of the natural logarithm s
5
e = Che n atu re c o n sta n t, base o f the natural logarithm s
j = number of step s or sta g es i = the i 1-*1 s ta g e among th e j a^=* background e f f e c t a t th e i 1"*1 sta g e
a^> 0
b^= dose e f f e c t at the i c^ sta g e d = dose
b^i 0
M ultiplying out the product term in th is equator giv es: 23
Q = aQ + q^d + ^2^ + ^3^ +
The q^ now are th e r e s u lt s o f th e ap p rop riate p r o d ic ts o f th e a^ and b^ (some o f the b^ could equal z e r o ) . i s the product o f th e a^
The term e- Q can be w ritten in an "expanded" form as
i - Qy + 32_2!___3331! + S4!_4 . . .
where N! = N (N -i)(N -2 ) . . .1 w r itin g t h is term 2t h is way le a d s to P = 1 - (1 1 Q + + . . .)
= Q^4 2!2 + L3!3 . (a 0 + ci1d + q2d2 + ) - (a Q- qxd + q2d2 + 21
Where the d ose, d, is r e la tiv e ly sm a ll,
13799
-2-
The higher degree terms used are even sm aller in comparison w ith d ( i . e . the s o -c a lle d lin e a r term q^d dom inates) le a v in g , as a f ir s t approxim ation at low doses of d
p = ao + q][d,
which is
The general form for the so -c a lle d " lin ea r, no-threshold" dose
response curve.
Further developments of the m u lti-stage model have led to at
lea st five additional concepts:
1. In extrap olatin g from animal r e su lts to p o ssib le d isea se in cid en ce in humans a s a fe ty -fa c to r is sometimes oinntrtohdeuceesdtimbya teu sifnogr qth^e (ut hppiser i s95%u scuoanllfyid elanbcee llleimd itq^ ) . U(qn^dearbtohvoe)se dcoierscunmotstadnocmeisnaitne, wshoichth atht e thlien eparro btaerbmility eq u ation may be o f the form P = a Q + q^d + q2d2 + . . .
ifi
ot. er
h .
aths
i
sb
eecnu
r vsheownno
ntehtahte
l tehs es
uupsupearllyco ntafkideesn cae lilnime airt
ffoorrmm ,
P = a o + q^1.* d .
Husoewdevfeorr, ethxetr ampoorelaitniotenn.ded form o f the eq u ation can be
2. The stage at which a carcinogen a ffe c ts the c e ll (or the
Bcaaporpthceiantrhoaegnecleneivcoef
p l
trhaonecdecs ads )nucrmeartoi odi nni f i eot hsf
e
ethxa
epf foetsciumtreeed
c a
opr euo
rposueflaoctofionntshe. eq
u
enc
e.
For person s whose exposure has ended, Brown and Chu
AE(Bxnraaomlwypnsle,is oCof.CfL. PuanrngodsCpKaen.cCcti.evreCahnaudn, dAERxpppeortrsouoarcsehpeetscottivoAerEsSepntiudicdemieiniso:logic
Environmental Epidemiology: Risk A ssessm ent,
P roceed in gs o f a SIMS C on feren ce, Siam I n s t it u t e fo r
M athematics in S ociety) have shown th at by looking at
both r e la tiv e r isk s, and ab solu te excess risk s for a
su b stan tial population whose exposures have ceased it
should be p ossib le to determine whether dioxin behaves
-3-
13800
in humans as an early sta g e or as a la t e stage carcinogen -- or perhaps as both, as the animal data seem to im ply. A short " laten t period" (tim e from f ir s t exposure to the carcinogen to the appearance of the d isease) could in d icate ae sithae rla tae vesrtayg ep oitnentth ecaprcrioncoegses n ,(oorr, oaf cacorcuirnsoeg, enb oathc t)i.n g The appearance of cancer in r e la tiv e ly young persons is consistent with a short la ten t period.
Immunologic E ffe c ts - and p o ssib le consequences
Joseph K. P rin ce (Chapter 5 , Im m uno-toxicology and Chemical C arcinogenesis in: Environmental T oxicology P rin cip les and P ra ctices, S. Somani, and F. Cavendar, e d ., Charles C. Thomas, S p rin g field , 111. (1981) has w r itte n th a t "TCDD has th e c a p a b ility o f cau sin g im m unosuppression . . ." (follow in g the dosing of nursing fem ales). As support of the im m unotoxicity of dioxin he c ite s the work o f F aith and Luster (" In v estig a tio n s on the e ffe c ts of 2 ,4 ,7 ,8 tetrach lorod ib en zod ioxin (TCDD) on param eters o f v a rio u s immune fu n c tio n s , A nnals, N.Y. Acad. S c i. 1979). P rince a lso c ite s sev era l other authors and th e ir stu d ies on the e f f e c t s o f TCDD on immune fu n c tio n .
What i s o f su b sta n tia l consequence w ith r e sp ect to p o ssib le immunologic e f f e c t s in person s exposed to TCDD (Moody, e t a l . , 1984 "The C hronic H ealth E ffe c ts o f O ccupational Exposure to D io x in : Unanswered Q u estio n s, Am. Jour, of In d u str ia l Med. 5: 157-160, c it e se v e r a l " sca ttered reports" lis t in g a range of to x ic responses in workers in clu d in g "immunologic a ltera tio n s" ) i s the rep orted in c r e a se s in cancer in p erson s who were immune su p p ressed as part of various medical treatm ents. Irving Penn, deriving h is data from a r e g istr y of p a tien ts on immunosuppressive therapy (Penn, I . , 1979, Cancer A sso cia ted w ith im m unosuppression. Sec F CRC Handbook: s e r ie s in c l i n i c a l la b o ra to ry s c ie n c e , C lev ela n d , CRC p u b lish in g C o ., se e a ls o Hoover, R. and V.F. Fraumini, Jr. (1973) R isk of Cancer in Renal Transplant
-4-
Cancer p a tien ts, Lancet 2: 55-57) reported excessive incidence of reticulum c e ll sarcom as, K aposi's sarcoma, and other lymphomas and leukem ias. In ad d ition , an excess in skin cancer was a lso reported.
Recent reports of in creases in K aposi's sarcoma in persons with A cquired Immune D e fic ie n ty Symdrome (AIDS) (H.W. J a ffe e , Keewhau C hoi, e t a l. (1983), N ational C ase-C ontrol Study of K aposi's Sarcoma and P n eu m ocystites C a r in ii Pneumonia in Homosexual Men: P art 1 Epidem iological R esults. Annals of External Medicine 199 //2, pp. 145151) has r e a c tiv a te d concern about th e a lt e r a tio n o f immune fu n ctio n and the development of unusual forms of cancer. The prelim inary report by the A ir Force on the "Ranch Hand" study rep orts both e x c e ssiv e nonm elan otic skin cancers (not adjusted for su n lig h t exposure) and "no group d iffe r e n c e s (in immune fu n c tio n s) . . . a fte r adjustm ent" fo r age and smoking h a b its. However, th is statem ent is e s s e n tia lly negated in the te x t o f the report (page i i i ) where i t s ta te s "The assessm ent of th e immune system by la b o ra to ry te s t in g was compromised by e x c e s s iv e te st v a r ia b ility ." A d iscussion then follow s that mentions the unexpected fin d in g of age and smoking e ffe c ts -- and adjustm ents for th ese.
S t a t i s t i c s on Cancer in Humans Two s e t s o f s t a t i s t i c s on cancer in humans are o f conseq u en ce. The
N a tio n a l Cancer I n s t it u t e has p u b lish ed data from i t s own in cid en ce c o lle c t io n system (SEER, S u r v e illa n c e , E pidem iology and End R e su lts) and from the m ortality data c o lle c te d by the N ational Center for H ealth S t a t i s t i c s . Many o f th e se d ata are assem bled in NCI Monograph 57 " S u r v e illa n c e , E pidem iology, End R e su lts: In cid en ce and M o r ta lity Data: 197 3 -7 7 , NIH P u b lic a tio n No. 81-2330 US DHHS, NIH, NCI, B eth esd a, Maryland) P a r tic u la r ly p e r tin e n t are T able 10 B (p . 6 8 ) "Number o f M alignant and In Seta cases diagnosed 1973-77 as primary s it e , age group, and median age,
a ll races, m ales, a ll areas (in clu d in g Puerto R ico), Table 10 E which gives incidence rates per 100,000 by fiv e year age groups, Table 10 H which corresponds to Table 10 E, reporting death ra tes, rather than in cid en ce ca ses. Monograph 57 a lso g iv es data sep arately by w h ites and non-w hites, males and fem ales.
Because skin cancers (other than melanomas) are inadequately reported through the usual channels for which data on other cancers are reported, the N ational Cancer In stitu te has undertaken sp ecia l sampling stu d ies of skin cancer. A (prelim inary) report on the "incidences of non-melanoma sk in Cancer in the Unitfed S ta te s, 1977-78" (S co tto , J ., F ears, T ., e t a l.) w as p u b lish ed in 1980 as DHEW p u b lic a tio n No (NIH) 80-2154, and covered 8 geographic areas, ranging from M inneapolis-St. Paul in the North to New M exico in the Southw est.
An attem pt i s made in t h is rep o rt to account fo r the s u n lig h t e f f e c t (in w hites) by rela tin g age-adjusted rates to an index of u ltr a -v io le t B r a d ia tio n le v e ls (which were about tw ice as high in New M exico as in M inneapolis.) The age adjusted r a tes in M inneapolis were somewhat more than h a lf th o se in New M exico. H ig h est r a te s were rep orted in New O rleans and A tla n ta , and lo w est r a te s in D e tr o it. The c o r r e la tio n betw een UV-B and skin cancer rates is q u ite good-- but not ab solu tely 1 to 1. Age adjust ment is e sse n tia l, because ra tes r is e very rapidly w ith age. For example, the " a ll areas" ra te fo r w h ite men ages 35-44 were 156.8 per 100,000 compared to a r a te o f 1971.9 per 100,000 fo r w h ite men aged 7 5 -8 4 , a 12 fold difference.
Dioxin as a Highly Potent Carcinogen The Environm ental P r o te c tio n A gency's C arcin ogen esis A ssessm ent Group
as p art o f i t s review o f m a te r ia ls su sp ected o f b ein g p o s s ib le human carcin ogen s, has reviewed and tabulated the data on 54 m a teria ls.
Potency was defined in two ways, first, as the (linear) slope of the
dose resp on se curve (q^ , upper 95% co n fid en ce lim it ) in u n its o f
m illigram s per kilogram per day, and second, in u n its of m illim odes per
kilogram per day - the la tte r being an attem pt to take in to account
the d ifferen t m olecular w eights of the d ifferen t m aterials examined.
Among th ese 54 m a te r ia ls , the ch em ical id e n t if ie d by EPA as te tr a c h lo r o -
d ioxin had a slope (in mg/kg/day) of 4.25x10"*. The next h igh est slope
recorded (about l/7 th as steep) was for hexachlorodibenzo d ioxin,
5 .7 x l0 4 . On c o n tr a s t, th e slo p e fo r a fla to x in B^, con sid ered by some
persons to be the most carcion gen ic of the non man-made m a teria ls was 2.9x10 3 , approxim ately 1 4 0 -fo ld l e s s steep than TCDD. A nother h ig h ly potent m aterial by th is cirterio n was b is(chlorom ethye)ether, 9.3x10 3 . Benzene (based on human d ata) i s rep orted to have a slo p e o f 5 .2 x 1 0 -2 ,
making TCDD 10 m illio n tim es more p o te n t.
On a m olar b a s is , th e se same m a te r ia ls had th e fo llo w in g "potency"
v a lu es in Mm/kg/day
TCDD H (6 )CDD A fla to x in B^
1 X 10 2 X 10 9 X 10
BisCME Benzene
1 X 10 4
Other highly carcinogenic m aterials on a molar b a sis were
A ld rin B enzidine D ieldrin
D iethyinitrosaurine Ne- tNhiyt rlo suor-eNa Nm- neitthryols ou-rNe a
4 x 103 4 x io4 1 X io4 4 x 103
4 x 103
3 x 104
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1380
Cancer bio-assays of TCDD
At lea st a h alf dozen long-term laboratory studies have been conducted to ev a lu a te the c a rcio n g en ic p o te n tia l o f TCDD. Among the f i r s t was a r e la t iv e ly sm all stu d y by Van M ille r (Van M ille r , J .T ., J .J . L alich, J.R. A llen (1977) Increased incidence of neoplasms in rats exposed to low le v e ls of 2 ,4 ,7 ,8 tetrach lorod ib en zo-p -d ioxin . Chemosphere 6 (9, 10) pp. 537-544, and 625-632).
Dose o f TCDD in diet m g/kg/w eek
0 (controls) 0.001 0.003 0.01 0 .1 0.4 2.4 240 500
Dead by 2 b Week 95
0 6/10 .001 2/10 .005 4/10 .05 4/10 .5 5/10 1.0 * 5.0 * 500 A 1000 *
* a ll died w ithin 4 weeks
Number o f male ra ts With tumors
0 0 5 3 4 4 7
The tumors included a wide range in volvin g the te s te s , the liv e r , sk in ,
kidney, m uscles, brain, etc.
Richard Kociba o f Dow conducted a la r g e r stu d y , a ls o in r a t s , and in
both sexes which was su b ject to la te r d eta iled review of the pathology
(K ociba, R .J ., D.G. K eyes, and J.E . Beyer, 1978, R esu lts o f a two year
chronic to x icity acid oncogenicity study of 2 ,4 ,7 ,8 tetrachlorodibenzo-p-
d io x in in r a ts, T oxicology and Applied Pharmacology 4 6 (2 ), 279-303. See
a ls o a more expanded rep ort in the Annals of the New York Academy of
-8-
13805
Science 320: 379-404).
The r e su lts of the Kociba study in male anim als are:
Dose (m g/k g/d ay)
0 (controls) 0.001 0.01 0 .1
Number o f anim als w ith tumors
Tongue Hard P alate
0/76 0/51 1/49 1/34 1/50 0/27 3/42 4/30 (6/30 Squire)
female animals Dose
C o n trols
0.00 (22
1p
pt)
0.01 (220 ppt)
0(
.1 2.
2
ppb)
Animals with tumors
L iv er (Hcaerpciantoomc ealsl)u la r
L iv er pHlCa s&t ichynpoerdules
1/86 9/86 (16/86-)
t
PHaarlda te
Lung CSqauracminooums aCs e ll
1/54 (0/54 S) 0/86
0/50
3/50 (8/50S) 0/30
0/50
2/50
18/50 (27/50S) 1/27
0/50
11/49 34/98 (33/47S) 5/24 7/49 (8/47S)
There was l i t t l e d ifferen ce, except for the c la s s ific a tio n of h yp erp lastic liv e r nodules between Squire and Kociba.
The N ation al T oxicology Progran (NCI) com m issioned a study o f TCDD in r a ts and mice which was carried out by the I llin o is I n s titu te of Technology. The chem ical was adm inistered by stomach tube (gavage).
These are the report r e su lts in male rats:
138 GB
-9-
Dose mg/kg/wk
C(voenhtricolle ) 0.01 0.05 0.5
T A ' -
Type of tumor (in clu d in g h yp erp lastic nodules, and adenomas)
Subcutaneous tissu e fib ro sis Liver
Adrenal Cortex
Thyroid Adenomas
/Adenomas and Carcinomas
3/75
0/74 6/72
1/69
1/69
1/50
0/50 9/50
5/48
5/48
3/50
0/50 12/49 6/50
8/50
7/50
3/50 9/49
8/50
11/50
In fem ale r a ts , sig n ific a n t in crea ses in tumor in cid en ce was found (comparing con trols w ith the high dose anim als in subcutaneous tissu e fib ro sarcomas, liv e r (n eo p la stic nodules above and a lso n eo p la stic nodules plus carcionm as( and adrenal c o r tic a l adenomas. P itu ita ry adenomas were increased for a ll d oses, and th is increase was s t a t is t ic a lly sig n ific a n t for the low dose group (1/66 vs 5 /4 7 ).
Among th e m ice (B6C3F1) th ere was a s ig n if ic a n t e x c e ss o f liv e r carcinom as among the m ales when the high dose anim als were con trasted w ith the c o n tr o ls . Among th e fem a les, th ere were s t a t i s t i c a l l y s ig n if ic a n t ex cesses in subcutaneous tis s u e fibrosarcom as, lymphomas (and leukem ias and lymphomas combined) of the hem atopoietic system , liv e r neoplasm s (in to ta l) and fo lle c u la r c e ll adenomas of the th yroid.
Several skin painting stu d ies were also conducted on m ice, one under co n tr a c t to th e NTP (NCI) a t th e I l l i n o i s I n s t it u t e o f T echnology. There was an in crease of 3 to 6 fold in fibrosarcom as of the intigum entary system of both m ales and fem ales. In fem ales these increases were s t a t is t ic a lly s ig n if ic a n t fo r both TCDD ad m in istered a lo n e , and a ls o fo llo w in g a s in g le dose of 50/mg of D im ethylbenzauthracene. Other skin p ain tin g stu d ies
-10-
,,T A '
included work by Berry (Berry, D .L ., T .J. Glaga, J. DiG iovanni, and
M.R. Juchau (1 9 7 9 ), S tu d ies w ith ch lo r in a te d d ib e n z o -p -d io x in s,
polybrom inated b ip h en yls, and p olych lorin ated biphenyls in a two stag
system of mouse skin tu m origenesis: Potent a n ti carciongenic e ffe c ts ,
Ann N.Y. Acad. S c i 320: 405-415) showed th a t th e tim ing o f the ad m in istra tio n
of carcinogens could strongly a ffe c t suppress tum origenesis. Sim ilar
work has been rep orted by Cohen and c o lle a g u e s . (Cohen, G.M ., W.M. Bracken,
R.P. Iy er, D.L. Berry, J.K . S elk irk , and T .J. Slaga, 1979. A nticarciongenic
e ffe c ts of 2 ,3 ,7 ,8 tetrach lorod ib en zo-p -d ioxin on benzo(a)pyrenic and 7,12
d im eth ylb en z(a) anthracene tumor i n i t i a t i o n and i t s r e la tio n s h ip to DNA
binding, Cancer Research 39(10) 4027-4033).
P ito t (P ito t, H .G ., T. Goldsworthy and H. Poland, 1980. Promotion
by 2 ,3 ,7 ,8 tetrach lorod ib en zo-p -d ioxin of hepatocarcinogenesis from d ie th y l-
netrosam ini. Cancer Research 40: 3616-3620) reported that in a sm all two-
sta g e c a r c io n g e n e sis experim ent th a t 5 o f 7 r a ts greated w ith TCDD in
a d d itio n to DEN had h e p a to c e llu la r carcinom as in c o n tr a st to none in the
comparable control groups.
..
The EPA has rep orted th a t a d ose o f 1 .x 10 ^ m g/kg/day, based on
the stu d ies by Kociba, that the one h it and the m u lti-stage model estim ated
th at th ere would be an increased life tim e r isk of 1 .1 x 0 ^ w ith an upper 95% co n fid en ce lim it o f 1 .5 x 10--6 or 1 .6 x 10-6 w hether based on
the data from the fem ale or male anim als.
138G8
- li-
-a '<*'
ELLEN KOVNER SILBERGELD, Ph.D.
As a fu rth er supplement to Dr. S ilb e r g e ld 's Summary, P la in t if f s
state as follow s:
y
TCDD and 2 ,4 ,5-T can cause male m ediated tr a n sm itta b le damage
m anifested by b irth d efects, m iscarriages, and other untoward pregnancy
outcomes when certa in circum stances occur. These circum stances are when
th e amount o f exposure to TCDD and to 2 , 4 , 5-T , e ith e r a lo n e or to g eth er
(th is amount being measured by in te n sity and duration) is appropriately paired with the timing of that exposure in relation sh ip to sperm atogenesis
'i
and the p a rticip a tio n of the male in reproduction.
Dr. S ilb ergeld 's opinions are in four categories as delineated
in S ectio n IV o f her Expanded Summary. O pinion IV A r e la te s to anim al
data and animal to x ic ity . The grounds for her opinion are sp e c ifie d on
the two pages of c ita tio n s headed " S ilb ergeld - Animal T oxicology" and
beginning w ith " B leiberg, et a l . , 1964; A rchives o f Derm atology, Volume 89,
p. 793" and ending w ith "Tukey, e t a l . , 1982; C e ll, Volume 31, p. 275."
O pinion IV B r e la t e s to re c e p to r s and TCDD. The grounds fo r t h is
opinion are sp e c ifie d in the two pages headed " S ilb ergeld - Receptors/TCDD"
and beginning w ith "Vos, et a l ., 1973; Environmental H ealth P ersp ectives,
Volume 5 , p. 149" and ending w ith "Okey, e t a l . , 1980; Journal of
B io lo g ica l Chemistry."
O pinion IV C r e la te s to rep rod u ctive to x ic o lo g y . The grounds
fo r th is opinion are sp e c ifie d on the two pages headed " S ilb ergeld -
Reproductive Toxicology" beginning with "Courtney, et a l., 1970, Tker, a to g en ic E v a lu a tio n o f 2 , 4 , 5-T ; S c ie n c e , Volume 168, p . 864" and
ending w ith "Lamb, e t a l . , 1981; Journal o f T oxicology and Environm ental 1 . 3 8 u 9
H ealth, Volume 8 , p. 825." O pinion IV D r e la t e s to th e n eu ro to x ic e f f e c t s o f 2 ,4 -D , TCDD,
and 2 ,4 ,5 -T . The grounds for th is opinion are sp e c ifie d on the page headed "Silbergeld - Neurotoxicology" beginning w ith "Bleiberg, et a l., 1964; A rchives of Derm atology, Volume 89, p. 793" and ending w ith Pazderova, e t a l . , 1981; A rchives of Environm ental H ealth , Volume 36, p. 5."
In addition to the publications liste d on these seven pages, Dr. S ilb erg eld 's attendance and p a rticip a tio n in the educational and s c ie n tific conferences and symposia lis te d on th ese pages have contributed to her knowledge and th erefore are the bases of her opinion .
Her personal and p ro fessio n a l experiences in th ese fie ld s are fu lly delineated in her curriculum v ita e .
THEODOR D. STERLING, Ph.D .
V. GROUNDS FOR EACH OPINION
Items 2 through 7 are being attached to th is supplement to D r. S t e r lin g ' s Summary fo r a l l p a r t ie s . Item 6 , E v a lu a tio n o f Data subm itted by Vietnam ese in v e stig a to r s and In tern a tio n a l Group o f E xperts, however, the portions that Dr. S terlin g w ill rely on to form h is opinions has been c ited and quoted in S te r lin g , T. and Arundal, A ., The Epidem iology of 2 ,4 ,5 -T from 1969 to the p resen t, Journal of Northwest C oalition for A ltern a tiv es to P e stic id e s, A p ril, 1984, which a r tic le is being provided w ith th is Supplem ental Summary.
V. B. Specific Item 1 refers to Dr. S te r lin g 's a n alysis of the Kociba a r tic le .
The illu s tr a tiv e and dem onstrative graphs which Dr. S terlin g has prepared fo r h is a n a ly sis of K ociba's a r tic le are being attached hereto and in co rp o ra ted h e r e in . Item 2 , IARC Monographs on th e E v a lu a tio n o f th e C arcin ogen ic R isk o f Chem ical to Humans in clu d e 15 monographs w ith th a t t i t l e , Volumes 1 through 15, and include phenoxy h erb icid es 2 ,4-D, 2 ,4 ,5 -T and oth ers.
V. C. The a r t ic le c ite d from the In tern a tio n a l Symposium on H erb icid es and D e fo lia n ts in War were review ed by Dr. S te r lin g as w e ll as o th ers in th e Ho Chi Minh C ity Symposium in 1983 and th e r e le v a n t p o r tio n s th at Dr. S te r lin g w ill r e ly on are c ited in h is Arundal and S terlin g recent a r t ic le attach ed to t h is Summary.
">5- ,-'r i.
1 3. The B isa n ti, et a l. a r tic le is attached hereto and incorporated herein for a ll purposes.
V. C (2). The f ir s t two referen ces c ite d r e fe r to the In tern ation al Symposium on H erbicides prepared by Vietnam ese in v e stig a to r s and the relev a n t p ortion s are c ite d in Dr. S terlin g and Dr. A rundal's new a r tic le attached hereto and incorporated herein for a ll purposes. The third reference to Report to M inisters Veterans A ffa irs, Case-Control Study of C ongenital Anom alies, published by the A ustralian Publishing Service, Canberra, January, 1983, is a two volum e, published document put out by the A ustralian government and a v a ila b le for the defendants to obtain from the A ustralian government. This document in clu d es 300-400 pages and i t would be too voluminous to reproduce here.
V. C. I t should be em phasized th a t in th e Expanded Summary o f Dr. S terlin g , a typographical error occurred and the sentence should read: In a d d itio n , Dr. S terlin g w ill t e s t if y that there is ample evidence that exposure to 2 ,4 ,5 -T i s tera to g en ic in humans when the mother is exposed, and con vin cin g evid en ce i s now extan t . . ( i t should not read "not" e x ta n t).
Further References Items 2 through 7 under "Further References" are being attached hereto and incorporated herein for a ll purposes.
2. Dr. S terlin g 's an alysis of Kociba, et a l. is provided. 3. The stu d ie s c ite d below , the f i r s t two of the item s are c ite d in relevan t p ortion in Arundal and S te r lin g 's new a r tic le which is attached hereto for a ll purposes.
(3) Attached hereto for all.p u rp oses.
> .. ^ M r v .-TJ : :.
4. The underlying data from which Dr. S terlin g w ill form h is opinions were taken from computer tapes between the years 1969 to 1975 from the N ational Center for H ealth S ta tis tic s . A true and correct copy of th is computer tape m aterial is provided for a ll p a rties and attached to th is Supplem ental Summary. In a d d itio n , Dr. S te r lin g 's a n a ly sis from th is d a ta , or a summary o f th a t a n a ly s is , w i l l be p rovid ed and supplem ented w ith in two weeks.
13
-3-
UEANSITTEERDN STDAISTTERS ICDTISTORFICNTEWCYOOURRKT
In Re AGENT ORANGE Product L ia b ility L itigation
filed
in CLEW S OFFICE U. S. DISTRICT COURT C.D. N.Y.
1 i f
T IM I A.M.
X P.M.
(MADlLl C38a1s e s )
x
PLAINTIFFS AMENDED LIST OF FACT WITNESSES IN SUPPORT OF CLAIMS
MARCH 2 7 , 19 8 4
PL A IN T IFFS' MANAGEMENT COMMITTEE B26r oCo ko ulyrnt , SNt rewe e Yt ork 1 1 2 4 2 (212) 330 - 0900
sisei
138
PLA IN TIFFS' AMENDED LIST OF FACT WITNESSES IN SUPPORT OF CLAIMS
P la in t if f s subm it the fo llo w in g l i s t o f p o te n tia l w itn e sse s to be
c a lle d at tr ia l pursuant to the M a g istra te's P r e tr ia l Order No. 1 8 , dated March 26 , 1 984, r e se r v in g th e r ig h t to su p p lem en t th is l i s t w ith a d d itio n a l names and a d d resses from tim e to tim e as a d d itio n a l in form ation and w itn e sse s are d isc o v e r e d .
T hose w itn e s s e s d e sig n a te d w ith an a s te r ic k "*" have been d ep osed in th ese p ro ceed in g s. T heir a d d resses and th e n atu re o f r e le v a n t p o rtio n s of th e ir testim on y are as eq u a lly w ell-know n to the defendants as to the p la in tiffs .
The w itn esses not covered by the above r e se r v a tio n s, a re, as follow s:
DR. THOMAS ABOUD T oledo C lin ic T o led o , Ohio EDWARD E ADAMS G1O02RDOHNic kAo. r yANDLEaRneSON* N augatuck, C onnecticut
C a r d io lo g ist for M rs. Ford Th yr epaetretde nDs ai onnny. F ord f o r
8I1R2ENES uAsNs eTxONIK A u s t i n , TX 7 8 7 4 5 ARNOLDI, LOUIS B .* EUGENE BAK* D7LO7a2N2JALoDRl leaKv,.e lBCl eAaLlLDiMfroAirvNne* i a DONALD BARNES
Texas Disability Officer and friend of Jordans'
13816
1
E. D. BAUMGARTNER R. E . BAYNARD JEANNIE BEAVERS PF leorws oe rn nHe lo sDpeipt aalr tm e n t S y la w ia , Ohio B4 4IL0 4LIEB oMn An RieIE DBrEivLLe F t . W o rth , TX 7 6 1 1 6 CLOYCI G. BELL 4404 B onnie D rive F t . W o rth , TX 7 6 1 1 6 B1 ELPLarkTELWEaPyHONE OF PA. P h ila d elp h ia , Pa. 19101 WA .t t eBm. pBtEinLgLS to l o c a t e BING, PETER S .* ETCYL H. BLAIR*
JOHN BLISH A ttem pting to lo c a te AKAA.ttNeASmA. SpBtLCinOIgCTKYt,o MlOo. c a t e AWtILt eLmIApMt inBgLUMtoENAl oUcEaRt e JOSEPH L. BOLTON A ttem pting to lo c a te
J1A2C9K2 0 BOWReRlElsRw*o o d T r a i l C h e s te r fie ld , Ohio 44026 AALt t eBmOTpHtWinEgLL to l o c a t e
2
Knows th e h o s p ita l and b u sin ess stra in re Danny Ford
Danny Jord an 's m other Danny Jord an 's S tep F a th er Personnel records of G eorge E w alt
DDoewp oEsemd p ltowy eice e
G ov't C ontracting Or ef;f i cHe err cPu alerst i c u l a r l y
hHLimiagmh ibnSiocVht toieeo'tsln awfmrhioe nwdas o wf it h
13817
7
JAAtMteEmS pEti.n gBOWtoERSl o c a t e S T . LO UIS, MO. DAAt tNeImELp tBinRgAXTtOo N l o c a t e BOB BROWN A ttem pting to lo c a te ABRtOt eWmN,p tSinGgT. to l o c a t e DAVE BUNIN Ww itilhl es ux pp pe rlyt saudmdmr easrsy m aterials JOHN S . BUSH, J r .* WILLIAM CALLAHAN A ttem pting to lo c a te W est V irg in ia MELVIN CALVIN* B2 6e8r3k eBl euyen, a CVailsitfao r nWiaay
ARCItCitnHecmAiRnpDnt ianCtgAi S, EtoYO hlioo c a t e
ELLIS CASH A ttem pting to lo c a te EDWARD LEE CHANDLER* EDWARD E. CHAPMAN* 6748 N. E uclid G lad ston e, M issouri J . G. CHARLTON ROBERT L . CHONOLES* E23d iCs oann,n eNlelaw JDerrivs ee y
3
George E w alt's Foreman, 1975 Sine r vVeide tnwa mit h D an . J o r d a n Ws pirtahy eDdananyr e aFsord in E conom ist
Was w ith E w alt in V ietn am Form er member o f PSAC Canhde mdiicrael c troer g oo vf e rDnomw e n t know ledge v s . Dow 's know ledge and fa ilu r e to warn. T estim ony from p o in t of view of "Ranchhander" scpo nr ac ye rinngin gandf a dc tesf ool ifa t i o n Go fofviecrenrm en t C o n t r a c t in g
1388
EMIL CHRISTOFANO* GEORGE F . COLLINS
JA.t teGm. pCtOinPgELAtoNDl,o cJ ar t. e ; Not yet deposed DIANE COURTNEY* G49EORHGeEck &RMdA. RGE CRAWFAS K ennessaw , Ga. JOHN CRAWFAS AB etal achn tVa ,a lGl eeyo rRg ida. O6W1 -E8N3 &WBhETitTeYfo rCdRACWeFnISte r R d. T o le d o , Ohio ROBERT CROCKER A ttem pting to lo c a te
EUGENE D. CRITTENDEN, J r .*
ROBERT CROCKER A ttem pting to lo c a te WARREN CRUMMETT* 808 C rescen t D rive M idland, M ichigan GENE CUMMINGS A ttem pting to lo c a te Bc52/IoL4L WCCBeSUsRt NT5eISw7 tsh S t r e e t New Y ork , New York 10019
4
Re H e r c u le s' l i a b i l i t y DP ri roedcutcotrio no f, Rp ricohcmu roenmd ,e nVt a . f(aP irloucruer e mtoe nwt,arns u pi spsluy e sa)nd A sst. Gen. M anager, '64 Gen. Mgr. S y n th e tic s, 6 5 -7 2 (Re H e r c u le s) Government expert w itn ess on ca u sa tio n CSahwr icsh' sa n Bg erso thine r Daanndny S Fi sotredr
in Law C hris' B rother
MU soetdh erto ant adk edadD aonnf y Cfho rr is . treatm en t (6138?)
Amounts - d oin g away o f hd ee rt ebrsm -in eh a se x pt aops ue rs e to to V eterans I I 's D ir. S a les, 66-67 A sst. Gen. Mgr. S y n th e tic s 69078-6 8D u P on t Road W ilm ington, D e l.19807
Dow s c i e n t i s t ; e v id e n c e c o n c e r n in g Dow l i a b i l i t y issu es. Served w ith Jordan in V ietnam Ee yveidweint nc ee s sc o no bc esrenr ivnagt i o n s as to the con d ition Vor feiestitndhauema cl, o ude xne ttferoynl itaotofifo n and
13819
THOMAS P . DALBY A ttem pting to lo c a te S . S . DANIELS L. L. DANIELSON A ttem pting to lo c a te AEDtWteAmRDp tDinEgBOLtoT l o c a t e DIAZ, STAFF SGT. A ttem pting to lo c a te ACHt tAeRmLEpStinDgILLtEo Y l o c a t e KANSAS CITY, MO. ALItNtDe mA pDtIiMn gOLAto l o c a t e N e s c o n s e t t , New York CHARLES DISHNER M. DOJNY
OC5W2h2Ea5Nr lDSeuOsntLoINnV*,a lWl e eyst DVr iivr eg in a LAWRENCE E. DOTSON* WILLIAM DUFFIELD
CHARLES L. DUNN*
AJOtSt eEmPHp tDinUgQUEtoTTEl o c a t e Rocky P o in t, N .Y . J . M. EAGAN A ttem pting to lo c a te (Scheduled to be deposed on March 31, 1984)
5
p o ssib le photographie ec ox nh ti bi ni ut se;s . i n v e s t i g a t i o n GO of fvi'cte rc o n t r a c t i n g U .S .D .A . L ia s o n NACA
W ith E w alt in V ietnam
K erry R yan's B a b y sitte r
Car efhfaeli
cri amt ibannig,l
i
tNmyAaCnAyi s;sdueeevf esi
d n
ence dant
s
in a d d itio n to H ercu les.
On S u f f o l k C o u n ty P o l i c e
F orce w ith M ike Ryan
138
J8PA0oC2tK4o mDLa.ac ,kEeAMnRhaLerYay*tlha n dWay2 0 8 5 4 WAYNE EDWARD* PLATOON SGT. ELLY A ttem pting to lo c a te DAEt tNeNmISp t EinLgMORt oE L o c a te
Was w ith E w a lt in sp r a y areas. G ov't C ontracting O fficer
G73E1ORGPEen nW. P&in Ee sUNBIClEv d .EWALT
C l i f t o n Uftlghto, Pa.
TEN EYCK WM2 4Ii8Ls7Ls1IiAoMnV iaVA .iSeaFj nAo I,RFCCeLrOanUlaiGnf odHro*n i a FRED FALANA A ttem pting to lo c a te WILLIAM F . FALSEY* L6 7a0k6e CL ai tkye,v ieMw icDh irgiavne OTIS E . FANCHER A ttem pting to lo c a te FARMER, CAPT. A ttem pting to lo c a te L. E. FAST WILLIAM FENNER* HERCULES, INC. JACKSONVILLE, ARK. BETTY FMAYDA 1899 R apids Road H iram , Ohio MTHoOnMeAsSta rFyORABEvSen u e P h ilad elp h ia, Pa. JOHN J . FORD* 15 W interbury C ir c le W ilm ington, D elaw are
. aPnadr e fnat ms iol ifa rG ewo ritghe E w a lt fam ily a itu a tlo n
2692 W ith Danny Ford in sp rayed areas
BIO-TEST LABS W ith Danny Ford in sp rayed areas
C hris F ord 's B u sin ess partn er and good frien d (See Smayda) Fs errive ne dd oinf Gsaemoer g ea r eEaw ailnt who V ietnam
13821
6
KERRY & JEANETTE FORD 6507 Secore Rd. L am bertvi11e , M ichigan RAY & ROSE FORD 1 3 4 7H8ighSwo uayth C o u n ty L in e Ottowa Lake, M ich. 49267 MARGARET FORLANO FF ti .r s tD iSx ,t r eNe.tJ . JOSEPH W. FOWLER E( i/n4 Fj Ra Ai lN)KS
JOHN P . FRAWLEY*
H. G. FREDERICKS* VAL K. GAERTNER JESSE GERSHBERG AWE rtit.tehmDE.p wtGinallgat d ntinoe y Vl oice tantaem E a st S t. L o u is, Mo. A . W. GLENN HAROLD GILL*
C4F0Ht0E. 9RYWLSohrGatwOhN,nDeEeTKXT 7r6a1i3l 5 CHARLES E. GRANITO* R42A0YMOENsDs e xA . PGlaUcIeDI* M em phis, T en n essee
B rother of Danny Ford Danny F ord 's P aren ts S is te r o f G eorge E w alt 4Vw23iietdthn aCLmoammbbaito tStue p pinly , C hief tox ic o lo g is t H e r c u le s, re many cl iaaubs ai lt iiot yn ai snsdu e s
Dow a n a ly t ic a l c h e m is t who a lle g e d ly d ev elo p ed a n a ly tic a l m ethod for d2 e, 3t e,r7m,8i nTaCtDi oDn ino f ' 6 4 . Danny J o rd an 's s is t e r
13822
COLONEL HAIG A ttem pting to lo c a te W19A9LTAERLLEDR. TOHNARRRDIS. * NAUGATUCK, CONN.
Was w ith E w a lt in sp r a y area
D5 0A0V9ID FGo.r eHs Et LM* Kansas C ity , Kansas RICHARD HICKMAN* R oute 4 , No. 10 Yocum Rd. R ogers, Arkansas
JESSE HILSEN PAUL E. HOFFMAN* B1 2a0r2r inLgakt oe n S, h Io rl lei nDoriisv e N o r th GRAYDON HOLDEMAN* BENJAMIN B . HOLDER* 5203 BLOOMFIELD ST . MIDLAND, MICH.
HARRY HOLLAND A ttem pting to lo c a te RAY HOLMES*
Dow g o v ern m en t s a l e s Mgr. re Dow 's a ttem p ts to s e ll products in clu d in g h erb icid es to the governm ent
Dow M e d ic a l D ir e c t o r re h ea lth e ffe c ts in w orkers, fa ilu r e to warn and lack o f minimum e f f e c t l e v e l . Friend o f L am b iotte's Dow p la n t s u p e r v is o r wc hholo rcaocnnt er ;a c treed h e a l t h e ffe c ts and fa ilu r e to wDaironx ino f inDowen dk npo wr oleddugcet s o fin 1964
G. HOLSING DONALD HOLT A ttem pting to lo c a te VERNON HOUCK F22. 0 GWER. ARTDy le&r VADA HUKILL
8
G eorge E w a lt's Foreman '80
Danny J o rd a n 's In-Laws
13823
Magnum, O kl. 73554 THOMAS R. HUNT RAPHAEL H. HUSTON A ttem pting to lo c a te PETER INFANTE GAEtOteRmGEp tJinACg KStOo N l o c a t e JA1O2pHtNL. aJBnEsNd oNwINnGe S A ven u e Lansdowne, Pa.
DAVID JORDAN* AL2Y0u8NsNtEBi nrKa, eEsLTwXLoEoR7d8 7 0 4 R. EMMET KELLY* 6S6T5. SLOO.UISSK, INMNOE.R VAN A . KELLY A ttem pting to lo c a te P h ilad elp h ia , Pa. GEORGE C. KEMPSON* 143 South Gore W ebster G roves, M issouri EUGENE E. KENAGA* 1E2s8s1e xNv. i lWl ea,gnMer icRh oigaadn
FRANCIS KENNEDY* WILLIAM KIDD CARL & CARLA KING 33-42 Romaker T o le d o , Ohio
9
H ercu les ex-em ployee J a c k so n v ille , Arkansas G eorge E w a lt's Foreman la te '70s to ea rly '80s H igh S ch ool fr ie n d of G eorge E w alt who was tinim Ve ieatnnda mk noawt s sahmi se m edical problem s. Friend of Danny Jord an 's M onsanto W ith E w alt in V ietnam
Dow em p lo y ee re epannedvrisrlioisant ambnei clnietta,yl t oi sxsiuc ei tsy
wCf(oDilutaohnnsdne yCs)othurfFtirsoitrehwdnashd;tens Ds hotahefnenywyt haes Fc eorrodu'ss laengd whoaws mc aunch pain he was in . A ddress mR oamy aaklesro Rboead 33 2 0
13824
$ #
J . M. KIRGIS A. Y. KISTNER AKAttNeSmASp tCinIgTYt, o MlOo. c a t e AFSRTtAt. eNmKLOpWtUi.nISgK, LEMtMoOA. Nl o c a t e GEORGE KLINE J . KLINGMAN PH ILIP LANDRIGAN To be d eposed JULES LAM A ddress to come MA IdCdHrAeEsLs cLoAmMiBnIgOTTE J . K. LEASURE* MR.akRa.ndNa,o. I 2l l i-n oBiosx 157 FRANK LEMAK To be d ep osed P. R. LITTLE HAROLD A. LLOY DR. ANNETTE LYNCH SP chhiol aodlheol pu shei a L, aPnea . J . R. MALLET W. MALONEY DAAtVteEmMpAtNinNg to l o c a t e
THOMAS MARKWOOD* Jeep Corp. T94o0le dNo. , COo eh.io B lv d . ROBERT E. MASKILL* 41 E ast 53rd S tr e e t
10
D avid L a m b io tte's U ncle BL raomthb eiortteo f D a v id
E w alt's d au gh ter's p sych ologist
Em ployer o f L am biotte b efo re and a fte r V ietnam P a y ro ll R ecords and lo s t incom e re Danny Ford T-H A g r ic u ltu r e ; l i a b i l i t y issu es
Kansas C ity , M issouri RICHARD J . MARRESE*
JOHN MASON* L12e aTt haenrnheeras d D, eaSnu r r e y E n g la n d L . G. MAUREY In p ro cess of lo c a tin g APAtUteLmMp AtiYnFgIELtoD l o c a t e M. McCALLEY A ttem pting to lo c a te WILLIAM J . McCARVILLE* 12 R idge C rest C ourt C h e ste r fie ld , M issouri DONALD McCOLLISTER* M5 5i2d2la Wn d h, itMe hicahllig aSnt r e e t W9 6I5L1LIABMLACDK. GMOcELDLRORYD*. CALIFORNIA J1U8D9Y9 MR caKpIiNdSsEYRoad H iram , Ohio SGT. TIMOTHY MEDDOR
CS6 9TO1.L4. LWBOR.UUICMSEE, RMMCEOERY. EWRSAY ROY MEYERS CHARLES E. MINARICK SHERRY MOSHER T1 8o4l3e3d5o , WOihnicoh e s t e r R d.
DEBDAS MUKERJEE
11
B u sin ess p artn er of C hris Ford and c lo s e frien d (S ee M cKim nley) served w ith Jordan in V ietnam
Deposed Ju ly 27- 29, 1983 B usiness; manager of the Aksdtedrnraenisnesl . monaSy Ct rahelrssioss baFneodrd1 9 5 0 W inchester Government ex p ert. Deposed
13825
B7HO1oBlLlaNemnOdBpEa, R RPaoad
Was w ith E w alt in V ietn am
WILLIAM R. NUMMY 71 1 W. M ead ow b rook D r iv e M idland, M ichigan
Deposed O ctober 28, 1983
JcA/ oCKGIEREEONCHMS OUNTAIN P . 0 . BOX 229
POST
FILMS
P hotographic e x h ib its & personal ob servation s & in v estig a tio n s
TURNER FALLS, MA.
BRIAN O'CONNOR B5 5r4o5n xN, eNt h.Ye r. la n d A v e .
Friend of th e Ryans
J . F . O'CONNOR
SGT. THOMAS O'DONNELL
Served w ith Jordan in Vi etnam
DR. OERTNER
J . E. PALLARD
FRANCIS PANNETON
L. A . PARDEE
PHIL PENN
Amounts - d oin g away of herbs - has tapes to determ ine exposure to V eterans I I ' s
REBECCA PEPPER 6718 S ilverm in e D rive #1004 A u s t i n , TX 7 8 7 3 6
N eighbor o f J o rd a n 's
JB6A6rC4oKoFkEof.ri eePlsdEt T, EGRWrSoOivsNec oCn siirnc l e
Form er Dow em p lo y ee who Mar deapdrrcrhees,ssee1nd9t6a5itni vdmeuessettrainyt g concerning rab b it ear testin g
F . H. PLACET
WILLIAM L. POPHAM
C o n s u lt a n t to NACA
D16O0NALFDr ePdUeRrDicYk s b e r g D r iv e
Deposed January 5, 1984
12
Avon Lake, Ohio THOMAS RAFERTY New York C it y V2 6IR2 0GILQ uBa.i l RHOBi IlNl SODNr i v e Upper St. C la ir, Pa. 15241 V. K. ROWE
ROBERT R. RUMER CECIL RUSSELL 46 WINGFIELD ROW GLENDALE, MO. MKAi nUgRsEENP a Rr kYA, NN .Y . MICHAEL RYAN 54 Woodsdale Ave. Kings Park, N.Y. VICKY RYAN K54i nWg so oPdasrdka,l e NA. Yv.e . HENRY SADLER Florida
UMBERTO SAFFIOTTI
DR. SALTER
ED SAWGRASS SUSAN SCANLON
- 13 -
With Mike Ryan in Vietnam Deposed October 19, 1983
TDci saoosuwxus'iesacstoiflooaonrsgmi
wqes rtue
el C-ls
thialioiseanf
bi s;
l
ity Dow
knowledge of extreme
wt oaxr ni c. i t yD eapnods e df a Mi laurrceh 1t o6 ,
1983.
Deposed November 18, 198
D e p o s e d May 2 , 1983
Sknc ohwo so l KPerrirnyc' si p ae ld uwchaot i o n Mike Ryan's Father
Kerry's Grandmother
Boyhood friend of L a m b i o t t e ' s who was with him in Vietnam Government causation wct eoisnttntiremasoscnt ywdi trehef e ngf aos vec e,t ur naml e n t l i a b i l i t y issu e s and issuance of Bionetics DL eapboosreadt oMr iaersc hR, e1p9o8r4t . Dr. who t o l d L am b iotte to stop working.
Sister of George Ewalt
13827
ft 0
RPhi
pi
il
aedn e
Str lph
ej.
ea
t,
Pa .
WM14Ii dL11Ll aIAnWMd. , RSM.t .i.LScCAhHniAgdMarneBwRAs
ARTHUR J . SCHLESSINGER OLGA SCHNELL SUtnoinvye rBs ri toyo k H, eNi g. Yh.t s Dr . W. SCHUBACK LAPIN 0 . SCOTT R. B. SCOTT
RICHARD SCOTT
SGT. SHARKEY
D1S3Et 0X. 4T2ELRoWuBie.sa, tShHMeAorR.fPi e l d D r i v e A. E. SIDWELL
LARRY SILVERSTEIN
B1HE8a9Ty9TrYamRS,aMpAOi dYhDsioARd . J . G. SMERALDI CAPT. SMITH PLATOON LT. SMITH
14
bDhf aouewirslbiunfiroecresimds
et e
osro
f
wet omsaerpnltllhoieaynnegde
re
gNoovveemr nbmere n1t .6 , D1 9e8p3o s e d
Neighbor of the Ryans
Hercules employee. Depos ed . Danrda f tseadw wi ni t hV i eLtanma mb i o t t e David Lambiotte's platoon Sergeant in Vietnam Deposed October 20, 1983
Hercules employee. Depos ed . MDoawr c hf o, r m1 9e 6r 5 e mm pe el ot yi ne ge s r ea t Dow and o t h e r l i a b i l i t y ei sfsf ue ec st s ant od Dh oewa l tehm p l o y e e s . Deposed March, 1984. BWF ouhrastdi n' Fes ,sosr dp spl uaswr tengnoet ordst h r-foruiCeghnhrdi .s and personal s tr a in s Deposed August 17, 1983. With Ewalt in spray areas With Ewalt in spray areas
13828
TOM K SMITH
ROBERT SNODGRASS H u n t i n g t o n , W. Va.
With Danny Ford in Sprayed areas
H1 O1 W0 0A8RDCCam. eoSPEDNrCiEvRe Sun C ity , Arizona 85351
Developed rabbit ear test ei nm p1l9o4y1e e w. h iDl ee pao s eDdowO c t o b e r 21, 1983
L. P. SEITZ
A. JOHN SPEZIALE
Deposed October 26,1983
R31e1dwNoo. d UCmibteyr,la nCda lAi fvoernnu ei a 9 4 0 6 1
JOHN A. STEPHENS 8S0t0. NL.o uLi si n, d Mb eirsgsho u Br il v d .
Deposed October 17, 1983
TF1R7u3EsDcWEaRlooIoCodKsl aanG, d. AFSlaTobEraWemAsaRt D, 3 5S4e0c5t i o n
Deposed 3
October
19,
1983
CHARLES N. STEWART
Deposed August 17, 1983
MICHAEL STRANGE 5F2t1. WBoomrtbher TRe xoaads
Friend of Danny Jordan
FS53ReEi dDSeE. nRM,ICaKNl l.YaSrT. dRANSKY
Mike Ryan's B roth er-in Law
SGT. STRAWBERRY
Was w i t h E w a l t i n s p r a y areas
D24EIRADlmREa ASTvReA. NSKY Seiden, N.Y.
Teacher - knows Kerry Ryan - a sp e c ia lis t in learning disabilities
P53ATSR.ICMIAa lSl aTrRdANSKY Seiden, N.Y.
Nurse and Family C ounseller for Ryan
family
JN7A1oC2rKt hS ShTCoRraUtrMoSl ipnoaon C i r c l e
Deposed December 16, 1983
JOHN S. SULLIVAN
W5 3I0N0FIEWLeDs tWp a. t hSUNWDaEyRLAND
Deposed November 2, 1983
13828
15
Bethesda, Maryland DANIEL W. SWEET MILTON A. TAVES W21i0l mNi.n gSt opnr ,i n gD eVl aawl al er e Road CLINTON TAYLOR
R. D. THOMPSON W31I8LLIGAEMORTGHINOAMPASOVNE. SANTA MONICA, CAL. A. L. TREISBECK
WDAoNodTlaWnIdSS S t r e e t S lyvian, Ohio
DAN TWIFF S4 9y1l0v a Wn ioao,dlaOnhdio WILLIAM R. UDELL C60REVTEEALCWOOEOUDR, MO. EDWIN T. UPTON
W. VANDERVENTER JANE WARD 3 5 2 7 M. 151 Temperance, Mich. 48182 R4SOt M.BEeRLdTioauTiD.s ,rWi vMEeBiBsEsRo u r i 6 3 1 4 6 ADAM WENKUS Route 5 - Box 904 Waupaca, Wisconsin
16
Deposed July 6 , 1983 Hercules employee. Depos ed . Business partner of David Lambiotte's
Deposed March 24, and September 16, 1983 Hercules employee. Depos ed . UDanni onny cFoomr dm'iss s ijoonb . manA l saot a frien d of D an 's. Has information about union cpoe nr st or na nc te l (mc uartrteenr ts). aSnede also Twiss. C o m m i t t e e man a t AMC J e e p See Twiff above
T-H l i a b i l i t y i s s u e s Deposed April 7, and April 8 , 1983 Deposed June 3, 1983 Neighbor of Fords
Deposed October 31, 1983
Supply and d i s t r i b u t i o n , wd eafrenn; d af onrtms 'e r f aDielfuernes e t o M ilitary Supply Office
13830
employee
BUTCH WESTERLAND
Served with Jordan in Vietnam
HARTLEY WILDER SGT. J . WILLIS
Served with Danny Jordan in Vietnam
MARK G. WILTSE N. WIRZ WILBUR WOHLGAMUTH 49-21 Barton Place Slyvian, Ohio
L. K. WOOLFOLK JOHN WRIGHT
Deposed December 2, 1983 Union Stewart at Danny F ord 's - knew Dan when ht he e hawda g tehs e a ct a nt hc ee r t iamnde and th e c h a n g e s in Dan
R. WRIGHT
R. T. YATES YORK HOSPITAL MITCHELL ZARON KETTERING LABS CINCINNATI, 0.
FLaomrmb ei or t teem p l o y e r o f
CHARLES P. ZORSCH ROUTE 5 , BOX 30 PACIFIC, MO.
D e p o s e d May 3 , 1983
l i s t e d onThet h e napmaers t i easb'o v ep r iwoirtihtoyu t l i si dt se n tainf dy i nwg i l l i n bf oe r mdae tpioosne d a raet lf ui st ut sr e madya tbees . s u p pIlte miesn t etdh e a sp ltahien tdief pf so's i t iuonndse ras trae n dt ai nkge n . t h a t t h e s e
AGENT ORANGE PLAINTIFFS' MANAGEMENT COMMITTEE
By
March 27, 1984
13831
17
AGENT ORAN2G6BEROCOOPULKRALTYINNS,TTIRNFEEFWEST' YOM- RAKSNUAGI1TE1EM2 4E2N9T05 COMMITTEE 212-330-0900
), HU o. Sn.. MS haigr ias t Ar a. t eS c F i e i n d l i n U. S. D i s t r i c t Court E astern D i s t r i c t o f New York 225 Cadman Plaza West B r o o k ly n , New York 11201
March 27, 1984
Dear M agistrate Scheindlin;
gPInar ot irdoeunc "t -ALgMei nDaLtb iONl irota.yn3g8e1L"i t -
You List of original
w ill find enclosed Chambers copy of Fact W itnesses, per your Pretrial of which has been file d with the
P l a i n t i f f s ' Amended Order No. 18, the Clerk of the Court
today.
t h e h eI a wr iinlgl bhaenf do r ed eyl oi vue rt o mc oo pr rioews mt oo rdnei nf egn. s e c o u n s e l a t t h e t i m e o f
Yours very truly,
cBcy; HAanldl C o u n s e l
13832
(713) 222-2288
Law Offices of Benton Musslewhite, Inc.
Counselors at Law
609 Fannin Suite 517
Houston, Texas 77002
Ad r i
I 984
Telex: 775-446 Telex Call Back: LOBM HOU
M r s , Sh i ra Sche i n dl i n Mag i s t r a f e United States D is t r ic t Court E a s t e r n D i s t r i c t o f New Y o r k 225 Cadman P l a z a E a s t Room 285 B r o o k l y n , New Y o r k I I 20 I
Re: Expanded and R e v i s e d Summaries of Non-Causation Experts
Dear Mrs, Sche indlin :
Pursuant to your recent r u lin g s that the summaries s h o u l d be e x p a n d e d a n d g i v e n i n mor e d e t a i l I am e n c l o s i n g expanded summaries in connection with the f o l l o w i n g :
1. D r . R. K e n n e t h G o d w i n , an e x p e r t on e n v i r o n m e n t a l p o l i c y and r e l a t i o n s h i p s between b u r e a u c r a t i c ru le s and o r g a n i z a t i o n and p u b l i c p o l i c i e s .
2. Dr. James 0. Rasmuson, s p e c i a l i s t in a n a l y t i c a l c h e m i s t r y , i n s t r u m e n t a t i o n and general i n v e s t i g a t i v e chemis try and environmental chemi st ry.
3. Dr. W i l l i a m B. R e t a l l i c k , e x p e r t in c h e m i c a l p r o c e s s engineering.
4. Dr . R u p e r t C. B u r t a n , e x p e r t in i n d u s t r i a l and e n v i r o n mental medicine.
5. Dr . C l i f t o n C. C r u t c h f i e l d , i n d u s t r i a l h y g i e n i s t .
6. Dr. G a r y B a k k e n , human f a c t o r s and s a f e t y e n g i n e e r i n g .
7. Dr. D a n i e l T e i t e l b a u m , c l i n i c a l t o x i c o l o g i s t wi t h e m p h a s i s on e n v i r o n m e n t a l m e d i c i n e .
8. Dr. D o u g l a s M u s t e r , me c h a n i c a l and s a f e t y e n g i n e e r .
9. Dr. Jay Young, c h e m i s t and chemical l a b e l i n g e x p e r t.
1383o3 -
Mrs. Shira Scheindlin A p r i l I , 1984 P a g e Two________
10. Dr . D e n n i s G e o r g e H a a c k , s t a t i s t i c a n and e p i d e m i o l o g i s t .
11. An a d d i t i o n a l c o p y o f t h e o p i n i o n s o f D r . A r t h u r W. G a l s t o n , Ph.D. The reason t h a t t h i s one is i n c l u de d i s t h a t he w i l l g i v e h i s o p i n i o n on the a l t e r n a t i v e and s u b s t i t u t e h e r b i c i d e s w h i c h do n o t c o n t a i n d i o x i n .
We h a v e n o t e x p a n d e d on t h e s u mma r y o f D r . S t e v e n W y a t t , t h e e c o n o m i s t , i n a s m u c h a s y o u r P r e - T r a i l O r d e r No. 17 s e e ms t o i n d i c a t e t h a t i t w i l l be a n t i c i p a t e d t h a t t he e c o n o mi c s u m m a r i e s w i l l be p r o v i d e d a t a l a t e r t i m e . In a n y e v e n t , t h a t s ummar y s h o u l d be c o mp l e t e d in t h e n e x t few d a y s , i nasmuch as the e c o n o m i c da t a has now been t r a n s m i t t e d to Dr. W y a t t f o r t h e c o m p l e t i o n o f h i s expanded summary. With r e s p e c t to the summary of Dr. Jay Y o u n g we a r e h o p i n g t h a t t h a t s u mma r y w i l l be c o m p l e t e d t h i s week . We h e r e b y a d v i s e y o u t h a t we do n o t i n t e n d t o c a l I a s a w i t n e s s W i l l i a m S. Wood, c h e mc i a l s a f e t y c o n s u l t a n t . In a d d i t i o n , p l e a s e be n o t i f i e d t h a t we a r e s e e k i n g an e x p e r t i n t h e f i e l d o f a g r i c u l t u r a l h e r b i c i d e p r o d u c t s , t h a t i s s omeone in t h e f i e l d who ha s k n o wl e d g e of how t he v a r i o u s h e r b i c i d e s t h a t have been on the market si n c e the e a r l y 1960's work with res pe ct to d i f f e r e n t types of plants. T h is witness would compliment the testimony o f Dr, G a l s t o n in t h a t a r e a o f c o n c e r n . T h e r e i s s t i l l some h o p e t h a t we w i l l be a b l e t o g e t t h s u mma r y o f D r . T h e o d o r e Goldfarb of the Chemistry Department of the State U n iv e r s it y of S t o nn ib roo k and Dr. Conrad Berenson, economist at Baruch C o l l e g e in New Y o r k .
Mr s . S c h e i n d l i n I u n d e r s t a n d t h a t you are u p s e t by the d e l a y in g e t t i n g t h e s e s ummar i es e x pa nde d and by the form the summaries have taken. I understand your concern and I a p p r e c i a t e and admire the manner in which you are t r y i n g to push t h i s case to e a r l y p r ep ara ti on for t r i a l . I reco gnize t h i s as an un us ua l c a s e and r e q u i r e s more s t r i n g e n t c o m p l i a n c e w i t h t he u s u a l d i s c o v e r y r u l e s . H owe v e r , I do want t o r e i t e r a t e some o f t h e a r g u m e n t s we h a v e made p r e v i o u s l y a n d i n a d d i t i o n t o c i t e a couple of cases which indicate that perhaps the h y p e r t e c h n i c a l i t y of the d e f e n d a n t s hasg o t t e n out of hand. You have i n d i c a t e d on s e v e r a l o c c a s i o n s y o u r e c o g n i z e t h a t t h i s s i t u a t i o n i s much d ifferent than the causation expert w itn e sse s-tha t is a s it u a t io n dealin g with a no n-c au sati on expert w i t n e s s . Th is stems from the fa ct that most of the evidence these people need to r e a l l y e x p r e s s d e t a i l e d o p i n i o n s i s in the hands of the d e f e n d a n t s and w h i l e some
13834
M r s . Sh i ra Sche i n dI in A p r i l I , 1984 P a g e T h r e e _____________
o f i t i s a v a i l a b l e much o f i t h a s n o t y e t b e e n made a v a i l a b l e a n d we a r e s e e k i n g t h r o u g h a d d i t i o n a l d i s c o v e r y . In a n y e v e n t t h e s e p e o p l e have g i v e n , I s u b m i t , more t han i s n e c e s s a r i l y r e q u i r e d by Ru l e 2 6 ( b ) ( 4 ) ( A ) ( I ). In H o c k l e y v s . Zent I n c o p o r a t e d , 31 F R S 2 d 1225 ( D . C . M a r y l a n d , 1 9 8 0 ) t h e C o u r t e x p r e s s l y h e l d that all that is required under Rule 2 6 (b ) ( 4 ) ( A) ( I ) is a general summary and enough w i t h i n the summary to p l a c e the o p p o s i n g p a r t y on n o t i c e of t he g e n e r a l n a t u r e o f t he t e s t i m o n y o f t he e x p e r t w i t n e s s . T h a t c a s e r e v e a l s t h a t we h a v e c l e a r l y c o m p l i e d w i t h t h e s p i r i t a n d t h e t e r m s o f R u l e 2 6 ( b ) ( 4 ) ( A ) ( I ) . We a l s o a s k t h a t y o u n o t e t h e d i c t a i n Dow C h e m i c a l Compa n y v s . T a y l o r , 20 FRS2 d 673 (D.C. E.D. M i c h i g a n , 1976). The d i c t a in t h a t c a s e f u r t h e r i n d i c a t e s t h a t we a r e i n c o m p l e t e c o m p l i a n c e w i t h both the terms and s p i r i t of the r u l e s . I need not remind the defendants of the terms and p r o v i s i o n s of Rule I of the Federal Rules of C i v i l Procedure and th a t the e n t i r e concept of the Federa Rules is to deal with each party within the s p i r i t of f a i r n e s s and rea sona ble ne ss. It is qu ite obvious that the defendants h a v e be c o me t o t a l l y u n r e a s o n a b l e . The r u l e s , a s we a l l k n o w, eschew h y p e r t e c h n ic a l i t y . O bviou sly it is to the defendants b e n e f i t to have the cou rt impose s t r i c t time l i m i t s , very t e ch ni ca r e q u ir em en t s with r e s p e c t to d i s c o v e r y matt er s and to load the c a s e up w i t h u n n e c e s s a r y t e c h n i c a l i t y . I do n o t mean t o i m p l y that any of the requirements th a t you have imposed to date are unnecessary or not a p p r o p r i a t e . I si m ply say th at I would hope t h a t n o b o d y ' s r i g h t t o t h e i r day in c o u r t i s g o i n g t o be p r e j u d i c e d by a d h e a r i n g to t he c o u r s e d e s i r e d by the d e f e n d a n t s which is one of h y p e r t e c h n i c a l i t y and o v e r l y burdensome r e q u i r e ments. In summary, the ca se s and the r u l e s c l e a r l y i n d i c a t e that we h a v e g i v e n t h e d e f e n d a n t s f a i r n o t i c e o f w h a t t h e s e e x p e r t s wi l l t e s t i f y about and t h a t i s a l l t h a t i s r e q u i r e d by the r u l e s , p a r t i c u l a r l y Rule 2 6 ( b ) ( 4 ) ( A ) ( l ) .
Mrs. S c h e in d lin , I want to take t h is o p po rtunity to a p o l o g i z e f o r any dela ys th at you feel have been unreas on ab le. We h a v e do n e o u r b e s t t o d e a l w i t h t h i s d i f f i c u l t m a t t e r a n d i t h a s b e e n p a r t i c u l a r l y d i f f i c u l t f o r me i n v i e w o f t h e f a c t th at I have been in b a c k - t o - b a c k t r i a l s f i r s t in a maritime case i n v o l v i n g a s i n k i n g of a ship where I re present the f a m i l i e s of two p e o p l e who l o s t t h e i r l i v e s in t h a t c a t a s t r o p h e and t h e n t h i s week I have been in t r i a l in a h e l i c o p t e r c as e i n v o l v i n g t h e de a t h o f e i g h t fami I i e s , who s e s u r v i v o r s I r e p r e s e n t . I h a v e a r r a n g e d my s c h e d u l e s o t h a t t h e s e a r e t h e l a s t t r i a l s I wi l l p a r t i c i p a t e in p r i o r to the Agent Orange case going to t r i a l .
13835
Mrs. Shira Sche in dli n Apr i I I , 1984 P a g e F o u r ______________
Whi le I h a v e d e l e g a t e d a p o r t i o n o f t h e w o r k w i t h r e s p e c t t o the non-causation exp erts, these are experts that I have used t o s ome e x t e n t ; I am f a m i l i a r w i t h t h e m, a n d t h e y a r e r e l y i n g upon me t o w o r k w i t h t h em i n t h e c o m p l e t i o n o f t h e s e s u m m a r i e s In s u mma r y , I do b e l i e v e we h a v e c o m p l i e d w i t h t h e r u l e s a n d I r e s p e c t f u l l y submit that these witnesses c e r t a in l y should not be p r e c l u d e d .
S i nce re I y
LAW O F F I C E S OF BENTON M U S S L E W H I T E , I NC.
Benton Musslewhite
BM : th Enclosures
c c : A L L COUNS EL OF RECORD (SEE ATTACHED SERVICE LI ST)
SERVICE LIST
Morton B. Silberman, Esq. CLARK, GAGLIARDI & MILLER The Inns of Court 99 Court Street White Plains, New York 10601
Wendell B. Alcorn, Jr., Esq. CADWALADER, WICKERSHAM & TAFT One Wall Street New York, New York 10005
John Sabetta, Esq. TOWNLEY & UPDIKE 405 Lexington Avenue New York, New York 10174
William Krohley, Esq. KELLEY, DRYE & WARREN 101 Park Avenue New York, New York 10178
David R. G r o s s , Esq.
BUDD, LARNER, KENT, GROSS, PICILLO & ROSENBAUM
33 Washington Avenue Newark, New Jersey 07102
Thomas A. Beck, Esq.
ARTHUR, DRY & KALISH, P.C. 1230 Avenue of the Americas New York, New York 10020
Arvin Maskin, Esq. DEPARTMENT OF JUSTICE Safeway Building Room 904 D Washington, D.C. 20530
Richard Goldstein, Esq.
SHEA & GOULD 330 Madison Avenue 15th Floor New York, New York 10017
Paul E
LEWIS,
sposito,
OVERBECK
E &s q
.
FURMAN
135 South La Salle Street
Suite 1060
Chicago, Illinois 60603
Howard Lester, Esq. LESTER, SCHWAB, KATZ & DWYER 120 Broadway New York, New York 10271
Stephen J. Schlegel, Esq. SCHLEGEL & TRAFELET, LTD. One North LaSalle Street Suite 3900 Chicago, Illinois 60602
Leonard Rivkin, Esq.
RIVKIN, LEFF, SHERMAN & RADLER 100 Garden City Plaza Garden City, New York 11530
Thomas Henderson, Esq.
BASKIN & SEARS Frick Building, 10th Floor Pittsburgh, Pennsylvania 15219
Victor J. Yannacone, J r . , Esq. YANNACONE & YANNACONE PP oa tsct h Oo gfuf ei c, e NBewox Y1o0r9k 11722
David Dean, Esq.
DEAN, FALANGA AND ROSE One Old Country Road Carle Place, New York 11514
Sol Schreiber, Esq. Special Master MILBERG, WEISS, BERSHAD
& SPECTHRIE One Pennsylvania Place Room 4915, 49th Floor New York, New York 10019
Clerk of the Panel Judicial Panel on Multidistrict
Litigation 1120 Vermont Avenue, N.W. Suite 1002 Washington, D.C. 20005
Newton B. Schwartz, Esq. Houston Bar Center Building 723 Main, Suite 325 Houston, Texas 77002
Stanley Chesley, Esq. WAITE, SCHNIDER, BAYLEFF
& CHESLEY 1318 Central Trust Tower Cincinnati, Ohio 45202
John 0. O'Quinn, Esq. O'QUINN, HAGANS & WETTMAN 3200 Texas Commerce Tower Houston, Texas 77002
Neal R. Peterson, Esq. GREITZER & LOCKS 1500 Walnut St., 22nd Floor Philadelphia, Pa. 19102
Hon. Shira Scheindlin Magistrate United States District Court Eastern District of New York 225 Cadman Plaza East Room 285 Brooklyn, New York 11201
Stephen Schlegel Agent Orange Management
Committee 26 Court Street, 9th Floor Brooklyn, New York 11242
Professor Michael Martin 165 W. End Avenue, Apt. 21-R New York, New York 10023
Benton Musslewhite, Esq. LAW OFFICES OF BENTON
MUSSLEWHITE, INC. 609 Fannin, Suite 517 Houston, Texas 77002
The Honorable Jack B. Weinstein United States District Judge Eastern District of New York 225 Cadman Plaza East Brooklyn, New York 11201
Phillip E. Brown, Esq. HOBERG, FINGER, BROWN, COX
& MOLLIGA 703 Market Street, 18th Floor San Francisco, California 94103
Robert A. Taylor, Jr., Esq. ASHCRAFT & GEREL 2000 L Street N.W., Suite 700 Washington, D.C. 20036
Ms. Nancy Petrillo, Clerk United States District Court Eastern District of New York 225 Cadman Plaza East - Room 285 Brooklyn, New York 11201
Irving Like, Esq. LAW OFFICES OF REILLY & LIKE 200 W. Main Street Babylon, New York 11702
Professor Aaron D. Twerski HOFSTRA LAW SCHOOL 1000 Fulton Avenue Hempstead, New York 11554
Ms. Jan Levien Agent Orange Management
Committee 26 Court Street, Room 905 Brooklyn, New York 11242
Allan Freidman, Esq. Chambers of Judge Weinstein United States District Court 225 Cadman Plaza East Brooklyn, New York 11201
13338
-2-
UEANSITTEERDN STDAISTTERS ICDTISTORFICNTEWCYOOURRKT
In re
"AGENT ORANGE' PRODUCT LIABILITY LITIGATION
x X
C E D,N.. _ CLERK'S OFFICE
U- o. DISTRICT COURT G.D. f
MDL 381
(All Cases)
' n 983 Tiy.Z A.M.
p.t.
PLAINTIFFS' SUMMARY PURSUANT TO RULE 26 OF TBHYAELLPFLISEATDIEENRRTAILFHFASRYU, CLAEONSNCOEEXFRPNECINRIGVT ILWNOITPNRN-COECASESUDSUATROTEIOBNEOFMCDAAOLTLCTETEDORRS
DATED: MARCH 2 6 , 1 9 8 4
PLAINTIFFS' MANAGEMENT COMMITTEE B r o o2k6l y nC,o uNret w SYt roerke t 1 1 2 4 2 (212) 330-0900
SUMMARY PURSUANT TO RULE 26 OF THE FEDERAL RULES OF CIVIL PROCEDURE OF DOCTOR ALLISTER HAY, EXPERT WITNESS TO BE
CALLED BY THE PLAINTIFFS CONCERNING NON-CAUSATION MATTERS
I.
QUALIFICATIONS
Dr. Hay's curriculum v ita e was attached to h is summary with resp ect to the ca u sation q u e s tio n s . Reference is now made to that curriculum v ita e and is incorporated herein by r e feren ce.
II.
SUMMARY OF SUBJECT MATTER OF WITNESS TESTIMONY
Dr. Hay's testimony with respect to non-causation m atters r e la te s to governmental a u th o rity and the d e c isio n making authority within the United States Government, with respect to t h e u s e o f h e r b i c i d e s i n V i e t n a m . He w i l l be b a s i n g h i s o p i n i o n s upon the e x te n siv e research done by him in preparation of h is book, "The Chemical Scyth e, Lessons o f 2 ,4 ,5 -T and Dioxin"; upon h is s c i e n t i f i c knowledge; and upon other documents and relevant authority with respect to the workings of the United States Government in connection with the use of herbicides in
13840
Vietnam and with respect to the lines of authority relative to
the exercise of such authority.
III.
FACTS UPON WHICH WITNESS WILL BASE OPINIONS
The f a c t s upon which Dr. Hay w i l l base h i s o p in io n s are those factual m atters e lic it e d by him during his in v estig a tio n and research in p rep a ra tio n for the w r itin g o f the above referred to book, The Chemical Scythe, and on the b a sis of other research and in v e s tig a tio n and f i r s t hand co n ta ct with s c i e n t i s t i s t and other people r ela ted to or involved in the use of h erb icid es in Vietnam during the 1 9 6 0 's. The fa c tu a l b a sis for most of the o p in io n s e x p r e sse d by Dr. Hay are s p e c i f i c a l l y stated in the above referred to book.
IV. & V.
OPINIONS AND THE BASES THEREFOR
1. I t i s the o p in io n of Dr. Hay th a t the d e c i s i o n s to use h erb icid es in Vietnam, to expand the use th e r e o f, and to continue to use such h er b ic id e s were made at the h ig h e st l e v e l s of government; s p e c i f i c a l l y , the i n i t i a l d e c is io n was made at a l e v e l no lower than Deputy S e c r e tr y o f d e fe n se Rowell G ilp a t r ic k and included S ecretary of S ta te Dean Rusk, S ecretary of Defense Robert MacNamara, and P resid en t Kennedy h im se lf. It is h is opinion that in subsequent adm inistrations the decision making was the same.
2. I t i s the o p in io n o f Dr. Hay th a t th e r e i s n o th in g in the statutes, regulations, executive orders, d irectives, customs, p r a c tic e s, p o lic ie s or prior modus operandi which would permit or suggest that the decisions referred to in (1) above could be, have been, or even should be, delegated below the highest le v e ls
13841
of the government.
3. I t i s the o p in io n o f Dr. Hay t h a t a l l su b seq u en t decisions to expand the program s p e c ific a lly required presidential approval. This would involve, of course, Presidents Kennedy, Johnson and Nixon.
4. It is Dr. Hay's opinion that the day-to-day d ecisin s as to where the spraying of the herbicidesw ould take p la c e , and as to the sp e c ific times for the use of the h erb icid es, was delegated to the United S ta te s Ambassador in Saigon and to the U nited S t a t e s M.A.C.V. ( M ilit a r y A s s is t a n c e Command, V ie tn a m ). However, th ese persons and e n t i t i e s did not have any resp o n sib ility for, or power to make, the ultim ate decision of whether to use or to continue to use the herbicides in Vietnam.
5. I t i s the o p in io n o f Dr. Hay th a t th e sp ra y in g o f crops with the herbicides required a request from the South Vietnamese au th orities before such crops could be sprayed.
6 . I t i s the o p in io n o f Dr. Hay th a t the B i o n e t i c s stu d y was the f i r s t indication to persons at a high enough le v e l of authority to have any impact upon ultim ate d ecicison making that the Agent Orange being used in Vietnam might have a contaminant in i t which could pose a danger to health . This study was placed in the hands of Deputy Secretary of Defense David Packard in O c t o b e r , 1 9 6 9 . He a l m o s t i m m e d i a t e l y i n s t r u c t e d t h e J o i n t C h i e f s of Staff to lim it the spraying of the Agent Orange to areas remote from population areas and remote from camp a r e a s , pending fu rther study and d e c is io n s about 2,4,5T in the United S ta te s domestic market.
7. I t i s the o p in io n o f Dr. Hay th a t in June o f 1970 Dr. K issinger, after gaining knowledgeof the Bionetics report, pursuaded Dr. Lee DuBridge of the P r e sid e n t's Science Advisory Committee to recommend to P resid en t Nixon th at the spraying
program be stopped a ltogeth er. President Nixon then asked the Deputy Secretary of D efense for an e v a lu a tio n of the e f f e c t iv e n e s s of the program and the dangers in v o lv ed . Though there was some e f fo r t on the part of the J o in t C hiefs of S ta ff to have the spraying continued on a lim ited b a s is , P resid en t Nixon continued the r e s t r ic t io n s in e f f e c t at thattim e and ruled that the use of the herbicides must conform to a ll the evolving r e str ic tio n s ontheir use in the domestic United S ta tes. In th is connection, it is Dr. Hay's opinion that in January 1970, the Department of Agriculture said that in the future 2,4,5T should contain le ss than one part per m illion dioxin.
8 . I t i s fu r th e r th e o p in io n of Dr. Hay th a t in March of 1971 the President's Science Advisory Committee advised the P resid en t and S e c r e ta r ie s of Defense that the minimum allow ab le le v e l of dioxin should be reduced from 1 part per m illio n to 0.1 part per m illion.
9. I t i s th e o p in io n o f Dr. Hay t h a t , on A p r il 13 , 1971, a fte r further in v e stig a tio n had continued and revealed the probability of severe adverse health e ffe c ts from dioxin, Secretary of Defense Melvin Laird ordered a ll residual stocks of Agent Orange with le ss than 1 part per m illion be returned to the United S ta te s and with regard to those sto c k s co n ta in in g any higher degree of dioxin, he ordered that they be incinerated.
10. I t i s the o p in io n o f Dr. Hay t h a t the P r e s i d e n S c ie n c e A dvisory Committee had no d e c is io n making power, only "advisory" power, and i t ' s fu n ctio n was to make recommendations to the President with respect to matters of sc ie n tific interest.
1 1 . I t i s t h e o p i nDiro.n Hoafy t h a t t h e r e l e v a n t members of the P r e s id e n t 's S cien ce A dvisory Committe had no knowledge of the potential health hazards of the herbicides being used in Vietnam until August - October of 1969. It is Dr. Hay's opinion that had the United S ta tes government had been
0O 4 0^
advised of the danger of Agent Orange, it could have used Agent White instead of Agent Orange, although Agent White was a slower acting defoliant.
12. I t i s the o p in io n o f Dr. Hay th a t even though B i o n e t i c s R e p o r t was r e l e a s e d i n May o r J u n e o f 1968 t o some government o ffic ia ls , while the President's Science Advisory Commission did not receive the report u n til 1969, there had been substantial spraying of Agent Orange in Veitnam and, as a resu lt, c o n s i d e r a b l e q u a n t i t i e s o f TCDD had b e e n d e p o s i t e d . T h a t TCDD would p e r s is t in the environment and s t i l l be a danger ( i . e . , s u b j e c t t o e x p o s u r e t o t h o s e i n p r o x i m i t y t o t h e TCDD) t h r o u g h 1969. I t i s the o p in io n of Dr. Hay th a t no agency o f the U nited S tates government at the decision-m aking le v e l was aware of the h ealth r isk s in 2 ,4 ,5 -T u n til August - O ctober, 1969. no agency of the United S ta tes government at the d ecisio n making le v e l was aware of the h e a l t h r i s k s in 2 , 4 , 5T u n t i l August - O c to b e r , 1969.
1 3 . I t i s t h e f u r t h e r o p i n i o n o f D r . Haoyn t thhaet , other hand sin c e before 1965, the Defendants' p ossessed a far g re a te r and v a ste r knowledge about the presence of d io x in in the 2 ,4 ,5 T ; the s e v e r e h e a lt h r i s k s to th o s e who were in v o lv e d in the manufacture of the 2,4,5T; the severe risks of adverse health a f f e c t s to t h o s e who were ex p o sed to th e use o f th e 2 , 4 , 5T; and th e p r o c e s s e s through which the d i o x i n c o n ta m in a n t in the 2 , 4 , 5T could be su b sta n tia lly reduced.
14. It is Dr. Hay's opinion that none of the defendants made a bona fid e e f f o r t to share the knowledge r e ferred to in (13) above u n t i l Dow w r o te t h e S e c r e t a r y o f D e f e n s e in March, 1970, a fter i t was too 1i t t le , too la t e .
15. I t i s Dr. Hay ' s summary o p in io n th a t th o s e who had the r e sp o n sib ility for making the d ecision s touse, or to continue
to use, or expand the use of, herbicides in Vietnam conflict, did
not u n til October, 1969 to A pril, 1971 know, or have reson to s u s p e c t , th a t the contam inant posed a danger to human h e a l t h , and that there were means for reducing the amount of the contaminant in the end product.
Respectfully submitted:
Thomas Henderson
13845
CERTIFICATE OF SERVICE
I , EDWARD F. HAYES, I I I do h e r e b y c e r t i f y t h a t t h e fo r e g o in g Rule 26 Summary was served upon the d efen d a n ts by Federal Express by delivering true copies thereof directed to them at the fo llo w i ng addresses:
AR ti vt okri nn e, y sL effofr, DShowermCahne m&i cRa la dCl eormpany G10a0r dGe nar dCeint y ,C iNt y. Y P. l a1z1a5 3 0 Cadwallader, Wickersham & Taft AOnt et o rWnaelyl s S ftor re e tD i a m o n d - S h a m r o c k New York, New York 10005 AS ht et ao r n&e yGso ufl do r U n i r o y a l , I n c . N33ew0 MY oardki s, o nNewA vYe nourke 1 0 0 1 7 Budd, Larner, Kent, Gross, A t Pt oircni el yl iso f o&r RTohsoemn tphsoanl C h e m i c a l N33e wWa raks,h iNnegwt o nJ e rSsterye e t1 7 1 0 2 AK tetlol er yn e yDsr y ef o r& WH earrrceunl e s , I n c . 101 Park Avenue New York, N.Y. 10178 Dated: March 26, 1984
Townely & Updike Attorneys for Monsanto Co. N40ew5 YL oe rxki n, g Nt oenw AYovrekn u e1 0 0 1 7 Arthur, Dry & K alish A1 2t3t 0o r nAevye snu ef o ro f Utnhier oAy ma le, r i Ic na sc . New York, New York 10020 AC tl at or rkn, e yGsa gfloi ra r dT&i H&AMg ri li lceurl t u r e W99h iCt eo uPr tl a Si nt rs e, e tNew York 1 0 6 0 1 Civil Division U n iJt euds t iSctea t e s D e p a r t m e n t o f WS aafsehwianyg t Bo nu,i l dDi.nCg. , 2 R0 5oo3m0 9 0 4 0
13346
-/ - T
UNITED STATES DISTRICT COURT EASTERN DISTRICT OF NEW YORK
In re "AGENT ORANGE"
Product Liability Litigation
)
) MDL No. 381
) (All cases)
PLAINTIFFS' INTERROGATORIES TO DEFENDANTS
MARCH 23, 1984
13847
k. Ansul
O T
. r i..
UNITED STATES DISTRICT COURT EASTERN DISTRICT OF NEW YORK
In re "AGENT ORANGE"
Product Liability Litigation
)
) MDL No. 381
) (All cases)
PLAINTIFFS' INTERROGATORIES TO DEFENDANTS
MARCH 23, 1984
1. Did you ever supply 2,4,5-T (in acid, salt, este
other form) to any of the following companies (please respond ]
or no for each company listed):
a. Dow Chemical Company
b. Monsanto Company
c. Diamond-Shamrock
d. Uniroyal, Inc.
e. T&H Agriculture
f. Hercules, Inc.
g. Thompson Chemical Company
h. Hooker Chemical Company
i. Riverdale Chemical Company
JL384&
j . Hoffman-Taft
a. Dow Chemical Company b . Monsanto Company c. Diamond-Shamrock d. Uniroyal, Inc. e. T&H Agriculture f. Hercules, Inc. g. Thompson Chemical Company h. Hooker Chemical Company i. Riverdale Chemical Company j . Hoffman-Taft k. Ansul 4. If your answer to any of interrogatory number 3 (a through k) is anything other than an unqualified "no", please state for each such party the following: a. Describe the writings relating to the (1) nego tiations leading up to, (2) the finalization of and (3) dealing pertaining to said receipt; b. For each such receipt occurrence, state (1) Was any of the 2,4,5-T received obtained from some other source and, if so, please describe the source and the date thereof; (2) The identification of your employee who was in charge of the receiving procedure; (3) The identification of the employee of the supplier who was in charge of the supply; (4) The date(s) of each such receipt; (5) The amount received on each occasion of receipt; (6) Whether there was any effort made by any person to
13849
determine the existence of and/or the amount of a dioxin
content and, if so, the results obtained and the identity of
all persons possessing the records pertaining thereto.
c. For each such receipt occurrence, please att
writings relating to or referred to in 4.(a) and 4.(b) above and
all writings relating to notice to any government entity concern
ing any dioxin content therein.
5. Did you ever supply 2,4,5-TCP (in acid, salt, ester or
other form) to any of the following companies (please respond yes
or no for each company listed): and list each of the defendants
a. Dow Chemical Company
b . Monsanto Company
c. Diamond-Shamrock
d. Uniroyal, Inc.
e. T&H Agriculture
f. Hercules, Inc.
g. Thompson Chemical Company.
h. Hooker Chemical Company
i. Riverdale Chemical Company
j . Hoffman-Taft
k. Ansul
6. If your answer to any of interrogatory number 5 (a
through k) is anything other than an unqualified "no", please
state for each such party the following:
a. Describe the writings relating to the (1) nego
tiations leading up to, (2) the finalization of and (3) dealings
pertaining to said supplying;
b. For each such supply occurrence, state
'4"
13350
(1) Was any of the 2,4,5-TCP supplied obtained from some other source and, if so, please describe the source and the date thereof;
(2) The identification of your employee who was in charge of the supply procedure;
(3) The identification of the employee of the recipient who was in charge of the receipt;
(4) The date(s) of each such supply; (5) The amount supplied on each occasion of supply; (6) Whether there was any effort made by any person to determine the existence of and/or the amount of a dioxin content and, if so, the results obtained and the identity of all persons possessing the records pertaining thereto. c. For each such supply occurrence, please at writings relating to or referred to in 6.(a) and 6.(b) above and all writings relating to notice to any government entity concern ing any dioxin content therein. 7. Did you ever receive 2,4,5-TCP from any of the follow chemical companies (please respond yes or no for each party listed): a. Dow Chemical Company b. Monsanto Company c. Diamond-Shamrock d. Uniroyal, Inc. e. T&H Agriculture f. Hercules, Inc. g. Thompson Chemical Company h. Hooker Chemical Company
-5-
i. Riverdale Chemical Company j . Hoffman-Taft k. Ansul 8. If your answer to any of interrogatory number 7 (a through k) is anything other than an unqualified "no", please state for each such party the following: a. Describe the writings relating to the (1) negotiations leading up to, (2) the finalization of and (3) dealings pertaining to said receipt; b. For each such receipt occurrence, state (1) Was any of the 2,4,5-TCP received obtained from some other source and, if so, please describe the source and the date thereof; (2) The identification of your employee who was in charge of the receiving procedure; (3) The identification of the employee of the supplier who was in charge of the supply; (4) The date(s) of each such receipt; (5) The amount received on each occasion of receipt; (6) Whether there was any effort made by any person to determine the existence of and/or the amount of a dioxin content and, if so, the results obtained and the identity of all persons possessing the records pertaining thereto. c. For each such receipt occurrence, please attach all writings relating to or referred to in 8.(a) and 8.(b) above and all writings relating to notice to any government entity concern ing any dioxin content therein. 9. Did you ever supply Agent Orange (in acid, salt, ester or
-6-
other form) to any of the following companies (please respond yes
or no for each company listed):
a. Dow Chemical Company
b. Monsanto Company
c. Diamond-Shamrock
d. Uniroyal, Inc.
e. T&H Agriculture
f. Hercules, Inc.
g. Thompson Chemical Company
h. Hooker Chemical Company
i. Riverdale Chemical Company
j . Hoffman-Taft
k. Ansul
10. If your answer to any of interrogatory number 13 (
through k) is anything other than an unqualified "no", please
state for each such party the following:
a. Describe the writings relating to the (1) nego
tiations leading up to, (2) the finalization of and (3) dealings
pertaining to said supplying;
b. For each such supply occurrence, state
(1) Was any of the Agent Orange supplied obtained from
some other source and, if so, please describe the source anc
the date thereof;
(2) The identification of your employee who was in
charge of the supply procedure;
(3) The identification of the employee of the recipient
who was in charge of the receipt;
(4) The date(s) of each such supply;
-7-
13353
(5) The amount supplied on each occasion of supply; (6) Whether there was any effort made by any person to determine the existence of and/or the amount of a dioxin content and, if so, the results obtained and the identity of all persons possessing the records pertaining thereto. c. For each such supply occurrence, please at writings relating to or referred to in 14. (a) and 14. (b) above and all writings relating to notice to any government entity concerning any dioxin content therein. 11. Did you ever receive Agent Orange from any of the following chemical companies (please respond yes or no for each party listed): a. Dow Chemical Company b. Monsanto Company c. Diamond-Shamrock d. Uniroyal, Inc. e. T&H Agriculture f. Hercules, Inc. g. Thompson Chemical Company h. Hooker Chemical Company i. Riverdale Chemical Company j . Hoffman-Taft k. Ansul 12. If your answer to any of interrogatory number 15 (a through k) is anything other than an unqualified "no", please state for each such party the following: a. Describe the writings relating to the (1 tiations leading up to, (2) the finalization of and (3) dealings
-8-
pertaining to said receipt; b. For each such receipt occurrence, state (1) Was any of the Agent Orange received obtained fror
some other source and, if so, please describe the source ar the date thereof;
(2) The identification of your employee who was in charge of the receipt procedure;
(3) The identification of the employee of the supplier who was in charge of the supply;
(A) The date(s) of each such receipt; (5) The amount received on each occasion of receipt; (6) Whether there was any effort made by any person tc determine the existence of and/or the amount of a dioxin content and, if so, the results obtained and the identity o all persons possessing the records pertaining thereto. c. For each such receipt occurrence, please attach all writings relating to or referred to'in 16.(a) and 16.(b) above and all writings relating to notice to any government entity concerning any dioxin content therein. 13. Were any of the aforementioned products (2,4,5-T; 2,4,5-TCP; Agent Orange) ever supplied to the United States Government? If so, for each incident of supply above described, state the following:
a . Describe which of the above products were so
supplied; b. Who supplied the product to the United States
Government; c. When was the product supplied to the United States
-9-
Government; d. In what quantity was the produce supplied; e. Was the origin of the product in any way described
to the United States; f. From who did the supplier receive the material
ultimately shipped to the United States.
-10-
CERTIFICATE OF SERVICE
The undersigned, Edward F. Hayes, I I I , does hereby c e r t if y that on the 23d day of March, 1984 he served the enclosed In te r r o g a to r ie s on a l l those shown on the attached s e r v ic e l i s t by delivery to Federal Express with the following exceptions; Chambers cop ies were d elivered person ally by hand to Judge W einstein and M agistrate S ch ein d lin , b e fo p a ^ h e hour of 5:00 p.m.
13
Oir' *V
Rivkin, Leff, Sherman & Radler Attorneys for Dow Chemical Co. 100 Garden City Plaza Garden City, NY 11530
Townley & Updike Attorneys for Monsanto Co. 405 Lexington Avenue New York, NY 10017
Cadwalader, Wickersham & Taft Attorneys for Diamond Shamrock One Wall Street New York, NY 10005
Arthur, Dry & Kalish Attorneys for Uniroyal, Inc. 1230 Avenue of the Americas New York, NY 10020
Shea & Gould Attorneys for Uniroyal, Inc. 330 Madison Avenue New York, NY 10017
Clark, Gagliardi & Miller Attorneys for T&H Agriculture 99 Court Street White Plains, NY 10601
Budd, Larner, Kent, Gross, Picillio & Rosenthal Attorneys for Thompson Chemical 33 Washington Street Newark, NJ 17102
Civil Division United States Department of Justice Room 904D Safeway Building Washington, DC 25030
Kelley, Drye & Warren Attorneys for Hercules, Inc. 101 Park Avenue New York, NY 10178
Q
1'
i.t : '
UNITED STATES DISTRICT COURT EASTERN DISTRICT OP NEW YORK
x
r \ IN RE
"AGENT ORANGE"
r\. PRODUCT LIABILITY LITIGATION
MDL No. 381 (All Cases)
x
\
SUPPLEMENTAL ANSWERS OF DEFENDANT MONSANTO COMPANY TO PLAINTIFFS' INTERROGA
TORIES TO DEFENDANTS
oI
To w n l e y & U p d i k e . CHRYSLER BUILDING
40 5 LEXINGTON AVENUE NEW YORK, N. Y. 10174
TELEPH O N E
v (2131 0 8 2 - * 5 6 7
UNITED STATES DISTRICT COURT EASTERN DISTRICT OF NEW YORK
X
IN RE
"AGENT ORANGE"
PRODUCT LIABILITY LITIGATION -X
*v
MDL No. 381 (All Cases) SUPPLEMENTAL ANSWERS OF DEFENDANT MONSANTO COMPANY TO PLAINTIFFS' INTERROGA TOR IES t o d e f e n d m s t s
Defendant Monsanto Company ("Monsanto"), pursuant to Magistrate's Pretrial Order No. 2, dated February 10, 1984 and as modified at a hearing that day before Magistrate Scheindlin, supplements its answers to certain of Plaintiffs' Interrogatories to Defendants, dated December 22, 1983, as follows:
INTERROGATORY NO. 3
Did any herbicide containing 2,4,5-T manufactured and ar sold by you contain any caution, warning, caveat or other statement or explanation on the product or its packaging?
a) If so, when did the warning or statement first appear?
b) What was the precise wording of the warning or other statement when it first appeared?
c) Has the warning or statement been altered, amended or changed in any manner? If so, how and when was it amended?
d) Where was the warning or statement located on each product or packaging?
13&Q
Answer to Interrogatory No. 3
The information in Monsanto's possession that is responsive to this interrogatory is found on the labels that were affixed to the various herbicides containing 2,4,5-T marketed by Monsanto. The burden of deriving the precise information sought in this interrogatory from those labels is substantially the same for the interrogating plaintiffs as it is for Monsanto. Accordingly, pursuant to Fed. R. Civ. P. 33(c), specified below are the numbers of the documents from which the answer to this interrogatory may be derived or ascertained :
0074525-0074526 0074515-0074516 0023203 0074506-0074507 0074297 0074296 0074658 0074611 0074772 0008369 0055143 0074399 0074396
0074597-0074598 0074793-0074797 0074569-0074572 0074683-0074684 0046973-0046974 0075199 0084205 0075130 0074697-0074698 0084280-0084281 0023204-0023206 0075105 0007097 0075063-0075064
1386 ^-
0074642 0074624 0074622 0075118 0074738 0074409 0074114 0074103 0023214 0074310-0074311 0074677-0074678 0054465-0054466 0074865-0074866 0074359-0074360 0075075 0074675-0074676 0074333-0074334 0007092 0074320-0074321 0074925-0074926 0074826-0074827 0074719 0008238-0008239 0046969-0046970 0074770-0074771 0074718 0084210
/s 0074679-0074680
0046965-0046966 0074717 0074280-0074281 0074278-0074279 0074099-0075623 0102064-0102065 0102066-0102067 0102068-0102069
INTERROGATORY NO. 7
Please list all scientific and medical periodical and
journals, both American and foreign, in which you claim the
toxic effects of dioxin were reported from 1945 to the present;
and, give the specific references to such reports for each such
periodical or journal.
138AC A'
-3-
0
Answer to Interrogatory No. 7
:
The information sought by this interrogatory is presently being compiled by or for Monsanto in preparation for trial. The bibliographic references listed below -- all of which are publicly available -- are thus not exhaustive. In listing them Monsanto does not waive, and hereby expressly reserves, its right to offer as evidence at trial any information concerning the toxicity of dioxin, regardless of whether such information is contained in the references listed below.
1. "UK Ministry Gives Green Light to 2,4,5-T," Nature, 2708 (5703), 3/29/79.
2. "Sponsors of Science Inc. on the Safety of 2,4,5-T and Dioxin," Clinical Toxicology, 7, 1974.
3. "National Health and Medical Research Council; Statements Adopted at 85th Session, Adelaide, June 1978," Medical Journal of Australia, 2/Suppl. 3, 10/21/78.
:r-s.
4. "Chlorinated Dioxins and Related Compounds: Proceedings of the Third International Sumposium Held at Salzburg, Austria, 12-14 October 1982," Chemosphere, 12 (4-5) 1983.
5. "Epidemiologic Evidence Shows No Longterm Threat Following Exposure to Dioxin," American Industrial Hygiene Association Journal, 41(3), 1980.
6. "No Excess in Cancer Deaths Found in Largest Group
Ever Studied for Long-Term Effects of Dioxin
.
Exposure," American Industrial Hygiene Association Journal, 41(1), 10/80.
7. "ACSH Notes Report Dioxin, DDT May Inhibit Cancer," Food Chemical News, 38, 11/28/83
8. "Malformation at Birth Increased in Seveso Last Year," Nature, 280, 7/79
13863
-4-
"Dioxin Traces Found in Soldiers Exposed to Defoliant, Nature, 282 (5742), 12/27/79.
"Dioxin and the Heart," Lancet, 1 (8183), 6/28/80.
"Resolution Conference Examines 2,4,5-T Safety," Farm Chem, 142(12), 12/79.
"2,4,5-T and TCDD," Naturwissenschaften, 63(10), 10/76.
"Simmering 2,4,5-T Dispute Boiling Over," Chemical Week, 126(15), 1980.
"TCDD: A Potent Inducer," Drug Metab Dispositions, 3(4), 1975.
"On the Trail of Dioxin," Scientific American, 229, 11/73.
"Dioxin and 2,4,5-T: What Are The Risks?" Nature, 284 (5752), 3/13/80.
"Another Herbicide on the Blacklist," Nature, 226, 1970.
"Cholorinated Phenoxy Acids and Their Dioxins: Genetics Summary," Ecological Bulletin, 27, 1978.
"The Dioxin Curse," Atlas World Press Review, 24, 11/77.
"Dioxin: The 10-Year Battle That Began With Agent Orange," Nature, 278, 3/8/79.
"Human Data (: A Short Article in William Robins' Description of Dow Chemical Company's Sponsored Studies SubjectingPrisoners to Dioxin)," Chemtech, 595, 10/83.
"2,4, 5-Trichlorophenol and TCDD," Naturwissenschaften, 63 (ISS 10), 12/23/76.
"The Strange Case of the Government vs. 2,4,5-T, Part II,"Farm Cham, 133(3), 1970.
"Dioxin Tolerance Level of 5 ppt Petitioned by Public Citizen," Food Chemical News, 10/24/83.
"Agriculture Group Says 2,4,5-T is Safe," C&EN, 9/11/78.
26.
27. 28. 29. 30. 31 .
32 . 33 . 34 . 35. 36. 37. 38.
39.
"Government Steps Up Pressure on Pesticides: Recent Joint Action Restricting Use of 2,4,5-T Herbicide Portends Changes in Pesticide Regulations and Testing," Chemical and Engineering News, 48(18), 4/27/70.
"The Effects of Herbicides in South Vietnam, Part A: Summary and Conclusions; Chapter VII: Effects on Humans," 1974.
"Mortality and Birth Defects from 1976 to 1979 in the Population Living in the TCDD Polluted Area of Seveso," 1982.
"Chlorinated Dioxins," Science, 220 (4606), 6/24/83.
"Data on Dioxin," Nature, 295 (5845), 1/20/82.
"Comparison on the Inducibilities of UDP-Glucuronosul Transferase and Polysubstrate Mono Oxygenase Activities in Mice Exposed to 20 Model Zenobiotics," Biochem Pharmacol, 32, 9/1/83.
"Effect of 2,3,7,8-TCDD on UDP Glucuronosul Transferase Activities in the Gunn Rat," Int. Congr. Ser-Excerpta Med., 440, 1978.
"Activiation and Inhibition of Rat Hepatic UDP-Glucuronosyl Transferase by Mercuric Acetate," Xenobiotic, 11(2), 2/81.
"Organ Specific Induction of Drug Metabolizing Enzymes by 2,3,7,8-TCDD in the Rat," Toxicol-Appl-Pharmacol, 44, 4/78.
"Dioxins," Duodecim, 96(12), 1980.
"Different Effect .of 2,3,7,8-TCDD on Glucouronide Conjugation of Various Aglycones: Studies in Wista and Gunn Rats," Toxicol Appl. Pharmacol, 47, 10/79.
"Photochemical Reactions of Phenoxy Acids and Dioxins," Ecol Bull, 27, 1978.
"Effect of Hypophysectomy and Castration on Hepatic, Pulmonary, and Intestinal Aryl Hydrocarbon Hydrolase Activities in the Rat," J .'Pharmacol Exper. Ther., 216, 3/81.
"Radioimmunoassay for 2,3,7,8-TCDD," Environ. Health Perspect., 20, 10/77.
r* IT*
-6-
if
4 0 . "Effects of 2,3,7,8-TCDD on Lipid Profiles in Tissues
of the Fissher Rat," Chem-Biol. Interactions, 23, 12/78.
41. "Health Implications of 2,3,7,8-TCDD Exposure in Primates," Environ Sci Res., 12, 1978,
42. "Morphological Changes in Monkeys Consuming a Diet Containing Low Levels of 2,3,7,8-TCDD," Food Cosmet
'S ' Toxicol, 15, 10/77.
43. "Response to Primates to 2,3,7,8-TetrachlorodibenzorhoDioxin," Toxicology Research Projects Di, 4(3), 1979.
44 .
"Response of Primates to 2,3,7,8-Tetracholordibenzorhodioxin," Toxicology Research Projects Di,, 5 (12), 1980.
45. "Reproductive Effects of Halogenated Aromatic Hydrocarbons on Nonhuman Primates," Ann. N.Y. Acad.
/ s Sci., V.320, 5/31/79.
46 .
"Reproductive Dysfunction in Nonhuman Primates Exposed to Dioxins," Toxicol Appl. Pharmacol., 41(1), 1977.
47. "Reproductive Dysfunction in Nonhuman Primates Exposed to Dioxins," Abstracts, Society of Toxicology, 3/30/77.
48. "Implications of Low Level Exposure to Dioxins," Toxicology Research Projects Di, 5(6), 1980.
49. "Dioxin Induced Toxicity and Carcinogenicity," Toxicology Research Projects Di, 4(6), 1979.
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56. "Seveso-Gift und Seine Toxizitat: Erkenntnisse Zum Wirkunqsmechanismus von 2,3, 7 ,8-TCDD," Deutsche Apotheker Zeitunq, 122(34), 1982.
57. "Comparison of Hepatic Enzyme-Inducing Activities of Chlorinated Dibensofuran and Chlorinated Dibenzodioxin," Fukuoka-Igaku-Zasshi, 65(ISS 1), 1974.
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i
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"Characterization and Regulation of an Intra-cellular Receptor Protein for Co-Carcinogens: A Receptor Regulating Chemical Initiation of Cancer," Cancer Treat. Rep., 63(7), 1979.
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"Neuropsychopharmacological Effect of TCDD," (Original paper in Italian), Boll. Soc. It. Biol. Sper, 54, 1978.
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"Time-Dependent Inhibition by TCDD of Skin Tumorigenesis with Polycyclic Hydrocarbons," Cancer Res., 40, 5/80
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"The Effects of 2,3,7,8-TCDD and Aroclor 1254 on 7, 12-DMBA Metabolism and Tumor Activity in Mouse Skin," (Meeting Abstract), Proc. Am. Assoc. Cancer Res., 19, 1978.
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"The Study of X-Rays and TCDD Effects on Satellite Associations May Suggest a Simple Model for Application in Environmental Mutagenesis," Hum. Genet., 61(1), 1982.
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Teratogenic Study of 2,4,5-T in- the Rat and Rabbit," Teratology, 4, 1971.
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"Relative Toxicity of Chick Edema Factors", Poult Sei., 52, 1973.
"TCDD Induction of Renal Microsonal Enzyme Systems: Ultrastructural Effects on Pars Recta (S3) Proximal Tubule Cells of the Rat Kidney", J. Pharmacol. Exp. Ther., 203, 12/77.
"TCDD Induction of Renal Microsomal Enzyme Systems", Toxicol. Appl. Pharmacol. 33(1), 1975.
"Ultrastructural Changes in Rat Liver Cells Following a Single Oral Dose of TCDD", Environ. Health Perspect., 5, 9/73.
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"Herbicides: A Mixed Blessing", Bioscience, 29(2), 2/79.
"The Ungreening of South Vietnam", Nat. Hist., 83(6), 1974 .
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"Pharmacokinetic Studies in Evaluation of the Toxicological and Environmental Hazard of Chemicals", Adv. Med. Toxicol., 1 (Part 1), 1976.
"Pharmacokinetics: First Order or Zero Order," Food Cosmet Toxicol., 14(6), 12/76
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"Chloracne and Clinical Impariment in a Group of Subjects Over 14 Years of Age, Exposed to TCDD in the Seveso Area," Ig. Mod., 77, 1982.
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"Assessment of the Contribution of Chlorinated Dibenzo-pdioxins and Dibenzofurans to Hexachlorobenzene-Induced Toxicity, Porphyria, Changes in Mixed Function Oxygenases and Histopathological Changes," Toxicol. Appl. Pharmacol, 46, 12/78.
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"Effect of 2,3,7,8-Tetrachlorodibenzo-l,4,-dioxin on Drug Metabolism in the Rat," Biochem. Pharmacol., 21, 1972.
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"Toxic Effects of TCDD," Food Cosmet. Toxicol., 11, 8/73.
"No Permanent Injuries at Seveso," Umschau, 2, 1978.
"Estimation of Isozymes of Microsomal Cytochrome P 450 in Rats, Rabbits and Humans Using Immunochemical Staining Coupled with Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis," Biochemistry, 21, 1982.
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"Effects of TCDD on Splenic Lymphocyte Transformation in Mice after Single and Repeated Exposures", Ann. N.Y. Acad. Sci, 320, 1979.
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"Contrasting Properties of Cytochrome P-450 Isozymes: Characterization, Identification and Significance of Multiple Forms of Rabbit Microsomal Cytochrome P-450", Dev. Biochem., 13, 1980.
"Purification of the Major Cytochrome P-450 of Liver Microsomes from Rabbits Treated with 2,3,7,8-TCDD", Biochem. Biophys. Res. Comm., 76(3), 6/6/77.
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"Dioxin Found in the Great Lakes Basin", AMBI, 10(1), 1981.
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"The AH Receptor: A Specific Site for Action of Chlorinated Dioxins?", Environ: Sci. Res., 25, 1983.
"Temperature-Dependent Cytosol-to-Nucleus Translocation of the AH Receptor for 2,3,7,8-TCDD in Continuous Cell Culture Lines", J. Biol. Chem., 255 (23), 1980.
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"Tissue Distribution, Excretion and Metabolism of 2,3,7,8-TCDD in the Golden Hamster", Toxicol. Appl. Pharmacol., 56, 1980.
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"Effects of TCDD (2,3,7,8-Tetrachlorodibenzo-P-Dioxin) on Striatal or Hypothalamic Adenylate Cyclase of Rat", Riv. Tossicol. Sper. Clin., 8, 1978
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"Chemistry and Toxicology of Polychlorodibenzo-PDioxins", Chem. Ind., 9, 5/1/82.
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439 .
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440 .
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441.
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443 .
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444 .
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445 .
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447 .
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448 .
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"Lipid Peroxidation as a Possible Cause of TCDD Toxicity", Biochem. Biophys. Res. Commun., 111(3), 3/29/83.
"Detection of Chemical-Induced Porphyria in Man: Possibilities in Biomonitoring of Exposure to Chemicals", Dev. Toxicol. Environ. Sci., 8, 1980.
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"Research Related to the Herbicide Burinol, Especially for Possible Carcinogenicity", IARC Sci Publ., 25, 1979 .
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470.
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471.
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472.
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476.
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"Multiple Forms of Cytochrome P-450: Catalytic Differences Exhibited by Two Homogenous Forms of Rabbit Cytochrome P-450", Mol. Pharmacol., 15, 15/79.
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"The Role of Iron in the Toxicity of 2,3,7,8-TCDD", Toxicol. Appl. Pharmacol., 61, 1981.
"Iron Deficiency Prevents Liver Toxicity of 2.3.7.8- TCDD", Fed. Proc Fed. Am. Soc. Exp. Biol., 38(3), 1979.
"Chlorinated Dioxins and Furans in the Environment", Environ Sci. Technol, 17(3), 1983.
"Ontogenetic Expression of Regulatory and Structural Gene Products Associated with the AH Locus: Comparison of Rat, Mouse, Rabbit and Sigmoden Hispedis", Dev. Pharmacol. Ther, 1980.
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"Correlation of Bioconcentration Factors of Chemicals in Aquatic and Terrestrial Organisms With Their Physical and Chemical Properties, "Environ. Sci. Techno1, 14(5), 5/80.
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"Polychlorodibenzo-P-Dioxins: Perinatal Effects and the Dominant Lethal Test in Wistar Rats", Adv. Chem. Ser., 120, 1973.
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......
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"Structural and Functional Studies of Ligandin, a Major Renal Organic Anion-Binding Protein, "J. Clin. Invest., 55, 5/75.
"2,3,7,8-TCDD Effects on Hepatic Microsomal Cytochromic P-448-Mediated Enzyme Activities", Toxicol. Appl. Pharmacol., 47, 3/15/79.
"Effects of TCDD on the Disposition of Heme and Heme-Containing Proteins in Mammalian Tissues", Toxicology Research Projects Pi., 5(ISS2), 1980.
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"2,3,7,8-TCDD Induction of Aryl Hydrocarbon Hydroxylase in Female Rat Liver: Evidence for DeNovo Synthesis of Cytochrome' P-448", Mol. Pharmacol., 14, 1978.
"2,4,5-T and Cancer", NZ Med. J ., 91, 1980.
"Modifying Effects of Environmental Chemicals on Drug Metabolism", Mutat Res, 46(3), 1977.
"Influence of Inducers and Inhibitors of Xenobiotic Transformation on Chemical Mutagenicity and Carcinogenicity", Pol. J. Pharmacol. Pharm., 31, 1979.
"Effects of Environmental Chemicals on Kidney Metabolism and Function", Kidney Int., 18, 11/80.
"TCDD Toxicity In Vivo and In Vitro . . . Toxicology of Halogenated Hydrocarbons", Health Ecol. Eff., 1981.
"2,3,7,8-TCDD Failure to Demonstrate Toxicity in Twenty-Three Cultured Cell Types", Toxicol Appl . Pharmacol, 54, 1980.
"A Search for the Presence of 2,3,7,8-TCDD in Beef Fat", Bull. Environ. Contam. Toxicol., 19(2), 2/78.
"Toxicity of 2,3,7,8-TCDD", Drug Metab. Rev., 13, 1982
"Long-term Toxicologic Studies of 2,3,7,8-TCDD in Laboratory Animals", Ann. N.Y. Acad. Sci., 5/31/79.
"Long-term Toxicologic Studies of 2 ,.3,7,8-TCDD in Laboratory Animals . . .: Health Effects of Halogenated Aromatic Hydrocarbons", Ann N.Y. Acad. Sci., 320, 1979.
"2,3,7,8-TCDD: Results of a 13-Week Oral Toxicity Study in Rats", Toxicol. Appl. Pharmacol., 35, 3/76.
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"Dioxins and Dibenzofurans", Lakartidningen, 76(7), 1979.
"Specificity of 2,4,5-T on Tetraethylammonium Transport", Toxicol. App. Pharmacol., 38, 1976.
"The Metabolism and Distribution of 2,4,5-T in Pregnant Mice", J. Environ. Sci. Health, 13, 1979.
"Aryl Hydrocarbon Hydroxylase Induction in Human Lymphocyte Cultures by 2,3,7,8-TCDD", Life Science, 15, 1975.
"The Dioxins: Toxic and Still Troublesome", Environment, 23(1), 1/81.
"Differential Effect of 2,3,7,8-TCDD on Nuclear RNA Polymerase Activity in the Rat Liver and Thymus", Biochem. Pharmacol.,31,8/1/82.
"Mechanism of Action of 2,3,7,8-TCDD on Hepatic RNA Synthesis", Dev.Biochem^, 13, 1980.
"Further Characterization of the Dioxin Receptor in the Rat Deciduoma", Biochem. Int., 68, (ISS 3), 1983.
"Accumulation of Polychlorinated Dibenzofurans in the Livers of Monkeys and Rats", Food Cosmet. Toxicol., 18(4), 8/80.
"The Effect of Environmental Pollutants on Human Reproduction, Including Birth Defects", Environ. Sci. Techno1., 15(6), 6/81.
"Evaluation of 2,4-D, 2,4,5-T and 2,3,7,8-TCDD Toxicity in C57B1/6 Mice: Reproduction and Fertility in Treated Male Mice and Evaluation of Congenital Malformations in Their Offspring", National Toxicology Program, NTP-80-44.
"Toxicity of Chlorinated Phenoxy Acids in Combination with 2,3,7,8-TCDD in C57B1/6 Male Mice", J. Toxicol. Environ. Health, 8, 12/81.
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"Exposure Measurements of Applicators Spraying 2,4,5-T in the Forest", J. Aqric. Food Chem., 28, 6/80.
"Dioxin (Dilemma)", Med. J. Aust., 1(13), 6/30/79.
"Metabolism of Benzo(A)Pyrene By Isolated Perfused Rat Testis", Cancer Res, 40, 1980.
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"Effect of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin on Renal Function in the Rat", J . Toxicol. Environ. Health, 2, 1976.
"Depression of Guinea-Pig Testicular Microsomal Cytochrome P-450 Content by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin TCDD", Pharmacologist, 21(3), 1979.
"Induction of Cytosolic Aldehyde Dehydrogenase Isozymes: Influence on Acetaldehyde Metabolism", Alcohol Aldehyde Metab.Syst, 2, 1977.
"Role of Liver Cytosolic Aldehyde Dehydrogenase Isozymes in Control of Blood Acetaldehyde Concentrations", J. Pharmacol. Exp. Ther., 201, 5/77.
"Excretion and Bile Flow Depression of Adenosine Triphosphate Activities in Isolated Liver Surface Membranes of TCDD Treated Rats: Correlation with Effects on Ovabain Biliary", J. Pharmacol. Exp. Ther., 201, 5/77.
"Reversal of 2,3,7,8-Tetrachlorodibenzo-D-Dioxin Induced Depression of Ovabain Biliary Excretion by Pregnenolone-16-Alpha-Carbonitrile and Spironolactone in Isolated Perfused Rat Livers", Toxicol. Appl. Pharmacol., 50, 9/30/79.
"Depression of Adenosine Triphosphatase Activities in Isolated Liver Surface Membranes of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Treated Rats: Correlation with Effects on Ovabain Biliary Excretion and Bile Flow", J. Pharmacol. Exp. Ther., 210, 1979.
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548 .
549 . 550 . 551 . 552 . 553 . 554 . 555. 556. 557. 558 . 559. 560.
"Effects of Pregnenolone 16-Alpha Carbonitrile and Spirino lactone on Biliary Excretion Ovabain in 2.3.7.8- Tetrachlorodibenzo-P-Dioxin Treated Rats", Toxicol. Appl. Pharmacol., 45(1), 1978.
"A Microbial Metabolite of TCDD", Experientia, 38(6), 6/15/82.
"Toxicant Deregulation of Endocrine Heme Bio-synthesis", Toxicology Research Projects DI/4, Iss. 06, 1979.
"Technical Pentachlorophenol: Origin and Analysis of Base-Insoluble Contaminants", Environ. Health Perspect., 15, P41-8, 9/1979.
"Photolysis of TCDD and Trifluralin on Silica and Soil", Bull. Environ. Contam. Toxicol., 20(1), 87-92, 7/78.
"Foreward to Papers I-VI: Accidental Release of 2.3.7.8- Tetrachlorodibenzo-P-Dioxin (TCDD) at Seveso, Italy", Ecotoxic. Environ. SAF, 4(3) 282, 1980.
"Increase of Hepatic and Serum Aldehyde Dehydrogenase Activity After TCDD Treatment", Arch. Toxicol (Suppl), 1, 1978.
"Studies on the Bioaccumulation and Microbial Degradation of 2,3,7,8-TCDD, Environ. Health Perspect, 5, 9/73.
"Absorption, Accumulation, and Elimination of Pesticides by Aquatic Organisms," Environ. Sci. Res., 10, 1977.
"Microbial Degradation of TCDD in a Model Ecosystem", Environ. Sci. Res., 26, 1983.
"Biochemical Aspects of Action-Mechanisms of 2.3.7.8- TCDD and Related Chemicals in Animals", Pharmacol. Ther., 19, 1983.
"Toxic effet of Chlorinated and Pyrethroid Pesticides", Toxicology Research Projects Pi., 5 (ISS 08), 1980.
"Factors Affecting the Disposition and Persistence of Halogenated Furans and Dioxins", Environ. Sci. Res., 26, 1983.
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"Gonadal Aryl Hydrocarbon Hydroxylase in Rats and Mice", Cancer Res., 38, 5/78.
"Oocyte Destruction by Polycyclic Aromatic Hydrocarbons", American J. of Industrial Med., 4, 1983.
"Ovarian Aryl Hydrocarbon Hydroxylase Activity and Oocyte Destruction", Microsomes, Drug Oxid., Chem. Carci., 2, 1980.
"Tetrachlorodibenzodioxin: A Survey of Subjects Ten Years After Exposure", Br J 2nd Med., 39(2), 5/82.
"A Study of Subjects 10 and 14 Years After Exposure," Chemosphere, 12, 1983.
"Chloracne From the Accidental Production of TCDD" Brit. J. Indus. Med., 30, 7/73.
"Tetrachlorodibenzodioxin: A Survey of Subjects Ten Years After Exposure", B r . J. Ind. Med., 39(2), 1982.
"The Comparative Toxicity of Chlorinated Dibenzo-pdioxins In Mice and Guinea Pigs," Toxicol. Appl. Pharmacol., 44, 1978.
"Toxicity of 2,3,7,8-TCDD in Rhesus Monkeys (Macaca Mulatta) Following a Single Oral Dose," Toxicol. Appl Pharmacol, 43(1), 1/78.
"Toxicity of Chlorinated Dibenzo-p-Dioxins in Mice, Guinea Pigs, and Rhesus Monkeys," Environ. Health Perspect., 20, 1977.
"Mechanism of 2,3,7,8-TCDD in Rats," Toxicology Research Projects Pi., 4(6), 1979.
"The Comparative Toxicity of Chlorinated Dibenzo-p-dioxins in Mice and Guinea Pigs", Toxicol. Appl. Pharmacol., 44, 5/78
"Structure-Activity Relationships in Halogenated Biphenyls: Unifying Hypothesis for Structural Specificity," Chem. Biol. Interact., 33(2-3), 1/81.
"The Study of Toxic Effects of Environmental Chemicals on Spermatogenesis", Toxicology Research Projects Pi., 56(ISS8), 1980.
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583 . 584 . 585. 586. 587. 588 . 589 .
"Induction of Aryl Hydrocarbon Hydroxylase Activity in the Rat Prostate Glands by 2,3,7,8-TCDD", J . Pharmacol. Exp. Ther, 215, 1980.
"Metabolism of Benzo(A)Pyrene in Rat Prostate Glands Following 2,3,7,8-TCDD Exposure, Carcinogenesis, 2, 1981.
"Factors Influencing Reproduction and Genetic Toxic Effects on Male Gonads", Environ. Health Perspect., 24, 1978.
"Genetic Differences in Benzo(A)Pyrene-Initiated Tumorigenesis in Mouse Skin," Pharmacol, 20, 1980.
"Differential Induction by 2,3,7,8-TCDD of Multiple Forms of Rabbit Microsomal Cytochrome P-450: Evidence for Tissue Specificity", Mol. Pharmacol., 18(3), 1980.
"Differential of Normal and Inducible Rat Liver Dehydrogenases By Disulfurame Inhibition in Vitro," B iochem. Pharmacol., 29, 11/1/80.
"Rat Liver Aldehyde Dehydrogenase Immunochemical Identity of 2,3,7,8-TCDD-Inducible Normal Liver and 2-Acetylamino Fluorene-Inducible Hepatoma Isozymes," Biochem^_Pharmaco 1_., 27, 1978.
"Environmental Pollution and Pregnancy Risks: Uncertainties for the Fetus and Infant", Am._J Obstet. Gynecol., 137(2), 5/15/80.
"In Vivo Cytogenic Studies on Mice and Rats Exposed to TCDD," Environ Sci., 5, 1982.
"Fire: The Dioxin Story to Date", Chemtech, 13, 10/83.
"Measurement of Enzymes in Environmental Intoxications", Ann. Clin. Lab. Sci., 7, 1977.
"Postnatal Stimulation of Hepatic Microsomal Enzymes Following Administration of TCDD to Pregnant Rats," Chem Biol. Interact.,11, 7/75.
"Perinatal Development of Conjugative Enzyme Systems," Environ. Health Perspect., 18, 12/76.
"TCDD-Induced Changes in Rat Liver Microsomal Enzymes," Environ. Health Perspect., 5, 9/73.
13905
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590 . 591 . 592. 593 . 594 . 595. 596.
597 . 598 . 599 .
600. 601.
602.
.v *
"Metabolic Activation/Deactivation Reactions During Perinatal Development," Environ. Health Perspect.. 29, 4/79.
"Nature of the Enhancement of Hepatic Uridine Diphosphate Glucuronosyl Transferase Activity by, 2.3.7.8-- TCDD in Rats," Biochem. Pharmacol., 24, 1975.
"Effects of Brief In Vitro Exposure to TCDD on Mouse Lymphocytes," J. Environ. Path. Toxicol., 2, 4/79.
"Immunochemistry of Dioxin Action on the Lymphocyte," Toxicology Research Projects Di., 4(ISS6), 1979.
"Immunochemistry of Dioxin Action on the Lymphocyte and Other Halogenated Aromatic Hydrocarbons", Toxicology Research Projects Pi. , 365 (ISS 7), 1980.
"Inability of Passive Antibodies to Reverse the Effects of Dioxin Toxicity", Chemosphere, 7(1), 1978.
"Examination of Bone Marrow Immunologic Parameters and Host Susceptibility Following Pre- and Postnatal Exposure to 2,3,7,8-TCDD", Int. J. Immuno Pharmacol., 2, 1980.
"Altered Immune Functions in Rodents Treated with 2.3.7.8- TCDD, Phorbol-12-Myristate-13-Acetate and Benzo(A)Pyrene", Banbury.Rep., 11, 1982.
"Metabolism of Carcinogens to Mutagens by Mammary Tissue Extracts", Proc. Am. Assoc. Cancer Res., 19, 3/78.
"Differences in the Nature of Induction of Mixed Function Oxidase Systems of the Rat Liver Among Phenobarbital, DDT, 3-Methylcholanthrene and TCDD", Toxicol Appl. Pharmacol., 61, 1981.
"Comparison of Induction Patterns of Rat Hepatic Microsomal Mixed-Function Oxidases By Pesticides and Related Chemicals", Pest. Biochem. Physiol., 11, 1979.
"Search for the Presence of 2,3,7,8-TCDD in Bovine Milk", Bull. Environ. Contam. Toxicol., 18(2), 8/77.
"Induction of UDP-Glucuronosyl Transferase Activity in the Reuben H-4-II-E Hepatoma Cell Culture", Mol. Pharmacol, 16, 1979.
-47- 390-
603.
604 . 605. 606. 607. 608 .
609 . 610 . 611. 612. 613 . 614 . 615 .
"Studies on the Requirements for Induction of UDPGlucuronosyl Transferase Activity in the Reuben Hepatoma H-4-II-E EstablishedCell Line", (Meeting Abstract), Pharmacologist, 19(2), 1970.
"Induction of Bilirubin UDP-Glucuronosyl Transferase Activity in Mice by 3-Methycholanthrene aijd 2.3.7.8- TCDD", Pharmacologist, 20, 1978.
"Persistent Tissue Levels of TCDD in the Mouse and Their Reduction as Related to Prevention of Toxicity", Drug Metab. Rev, 13, 1982.
"Studies of the Mecahnism of Toxicity of 2.3.7.8- TCDD", Ann. NY Acad. Sci., 320: 204-13, 5/31/79.
"The Toxicokinetics of TCDD In Mammalian Systems", Drug Metabol Rev., 13:355-85, 1982.
"Induction of Intestinal Iron Transport by 2.3.7.8- TCDD, an Environmental Pollutant and Potent Inducer of Aryl Hydrocarbon Hydroxylase," Clin. Res., 25(3), 1977.
"Intestinal Organic Union Transport Glutathione Transferase and Aryl Hydrocarbon Hydroxylase Activity: Effect of Dioxin," Life Sci, 24, 4/9/79.
"Stimulation of Iron Absorption by Polychlorinated Aromatic Hydrocarbons," Physiologist, 21(4), 1978.
"Induction of Iron Transport by a Potent Inducer of Aryl Hydroxylase, 2,3,7,8-TCDD," Arch. Environ. Health, 34, 6/79.
"Effects of Polyhalogenated Aromatic Hydrocarbons on Benzo (A) Pyrene Hydroxylase Activity in the Intestine and Liver," Life Sci. 26, 1980.
"Stimulation of Iron Absorption By Polychlorinated Aromatic Hydrocarbons," Am. J. Physiol., 236, 6/79-.
"Effect of 2,3,7,8-TCDD on Macrophage and Natural Killer-Cell Mediated Cytotoxicity in Mice," Biomedicine, 32, 12/80.
Alterations in the Herme Biosynthetic Pathway as an Index of Exposure to Toxins," Con. J. Physiol. Pharmacol., 60, 1982.
-48-
"Responses of the D-Glucuronic Acid Pathway in Rat Tissues To Treatment with TCDD," Xenobiotica, 8, 7/78
"Comparison of Phnobarbital - and Carcinogen Induced Aldehyde Dehydrogenzses in the Rat," Biochem. Biophys. Acta, 583, 2/19/79.
"High-Affinity Binding of 2,3,7,8-TetrachlorodibenzoP-dioxin in Cell Nuclei from Rat Liver", Biochimica et Biophysica Acta, 714, 2/25/82.
"Xenobiotic Metabolism in Marine Fish Treated 2,3,7,8 tetrachlorodibenzo-P-dioxin (TCDD), 3-Methylcholantrene (3-MC), or 1,2,3,4-Dibenzanthracene (DBA)", Pharmacologist , 10(2), 1976.
"Cytochrome P450 Content and Mixed Function Oxidase Activity in Microsomes Isolated from Mouse Skin:, Pharmacologist, 16(2), 1974.
"Biological Degradation of TCDD in Rats", Nature, 281: 10/25/79
"Chlorinated Dibenzo-P-Dioxins: Potent Inducers of Amino Levulinic acid synthetase and Aryl Hydrocarbon hydroxylase II. A study of the structure-activity relationship". Mol. Pharmacol. 9, 1973.
"2,3,7,8-Tetrachlorodibenzo-P-dioxin and Related Halogenated Aromatic Hydrocarbons: Examinations of the Mecahnism of Toxicity", Ann. Rev. Pharmacol. Toxicol ., 22, 1982.
"The Induction of Aryl Hydroxylase by 2.3.7.8- TetrachlorodibenzoP-Dioxin evidence for a Receptor Mutation In Genetically Nonresponsive Mice:, Pharmacologist, 16 (2), 1974.
"A Model for the Mechanism of Action of TCDD", Dev. Toxicol. Environ. Sci., 5, 1980.
"Stereospecific High Affinity Binding of 2.3.7.8- Tetrachlorodibenzo- P-Dioxin By Hepatic Cytosol", J. Biol. Chem., 251, 8/25/76.
"Chlorinated Biphenyl Induction of Aryl Hydrocarbon Hydroxylase Activity: A Study of the StructureActivity Relationship", Mol. Pharmacol., /13, 9/77.
Comparison of TCDD, a Potent Inducer of Aryl Hydrocarbon Hydroxylase, With 3-Methyl-Cholanthrene", Mol. Pharmacol., 10, 1974
13908
-49-
629. 630. 631. 632.
633 . 634. 635.
636 . 637. 638. 639. 640 .
641. 642.
"2,3,7,8-Tetrachlorodibenzo-P-Dioxin Environmental Contaminant and Molecular Probe" Fed. Proc. 35, 1/76
"Studies on the Mechanism of Action of the Chlorinated Dibenzo-P-Dioxins and Related Compounds:, Annals of the N. Y. Academy, 320, 1979.
Genetic Expression of Aryl Hydrocabron Hydroxylase Activity", J. Biol. Chem., 249, 9/10/74.
"Increased Total and High Density Liprotein Cholesterol With Apoprotion Changes Resembling Stretozotocin Diabetes In Tetrachlorodibenzodioxin (TCDD) Treated Rats", Biochem. Pharmacol., 29, 1980
"Hypothyroxinemia and Hypothermia In Rats In Response To 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Administration", Toxicol. Appl. Pharmacol. 69, 1983
"Teratogenetic Effects of Dioxin", Nature, 266, 3/10/77.
"Kenetics of N- and C- Hydroxylations of 2-Acetylaminofluorene in Male Sprague-Dawley Rat Liver Microsomes: Implications for Carcinogenesis", Cancer Res. 43(8), 8/83.
"Persistence of TCDD in Monkey Adipose Tissue", Food Chem. Toxicol, 20(6), 12/82.
"PCB and TCDD Orofacial Teratogeneis in M. Mulata", Toxicology Research Projects, Di 4, 1979.
"Toxicity of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin for Rhesus Monkeys: Brief Report", Bull. Environ. Contam Toxicol., 18(1), 7/77.
"Mutagenic Study of Chlorinated Derivatives of Azobenzene", Arch. Int. Physiol. Biochem., 86, 4/8/78.
"Biochemical and Genetic Analysis of Variant Mouse Hepatoma Cells Defective in the Induction of Benzo(A)Pyrene-Metabolizing Enzyme Activity", J. Biol. Chem., 258, 1983.
"Hetorogeneity in the Rate of Benzo(A)Pyrene Metabolism in Single Cells: Quantification Flow Cytometry", Mol. Cell Biol., 2, i.982.
Immunologic Response and Factors Affecting Its Assessment", Environ. Health Perspec., 18:125-131, 12/1976.
-50-
643. 644 . 645. 646.
647 . 648 . 649 . 650 .
651.
652 .
653 . 654 .
"Toxicity of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin", ECO. Bull., 27, 1978.
"Evaluating the Rodent Immune System As a Focus for Teratogenic Effects", Teratology, 9(3), 1974.
"Characterization and Interpretation of Kidney Anomalies Associated with 2,3,7,8-TetrachlorodibenzoP-Dioxin: TCDD", Teratology, 7(3), 1973.
"Long-Term Status of Workers Previously Exposed to 2.3.7.8- Tetrachlorodibenzo-P-Dioxin in the Manufacture of 2,4,5-T", Abst. Pap. Am. Chem. Soc , 182(o), 8/28/81.
"Soft Tissue Sarcomas" Phenoxy Herbicides and Chlorinated Phenols", Lancet, 1 (8234), 6/20/81.
"Evaluation of Results of Chromosome Analysis on Lymphocytes of TCDD Exposed Subjects After the Services Accident", Mutat. Res-., 35, 1981.
"Three-Generation Reproduction Study of Rats Given 2.3.7.8- Tetrachlorodibenzo-P-Dioxin (TCDD) in the Diet", Tox. Appl. Pharmacol., 50, 9/15/79.
"A Comparative Study of Polychlorinated Dibenzofurans, Polychlorinated Biphenyls and 2.3.7.8- Tetrachlorodibenzo-P-Dioxin on Aryl Hydrocarbon Hydroxylase Inducing Potency in Rats", Arch. Toxicol., 53, 1983.
"Comparison of Benzo(A)Pyrene Metabolism by Testicular Homogenate and the Isolated Perfused Testis of Rat Following 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Treatment", Arch. Toxicol., 51, (2)8, 1982.
"Morphologic Alterations Induced by TCDD (2,3,7,8-Tetrachlorodibenzo-P-Dioxin) in Epithelate Monolayer Cultures of Human and Rodent Fetal Lung, Kidney and Liver", Int. J. Biol. Res. Pregnancy, 2, 1981.
"Transfer of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) The Mouse Embryo and Fetus", Toxicol, 20, 1981.
"Factors Affecting the Induction of DT-DIA Phorase by 2.3.7.8- Tetrachlorodibenzo-P-Dioxin (TCDD)", Biochem. Pharmacol., 27, 2/15/78.
-51-
655. 656. 657. 658.
659 . 660 . 661. 662 .
663 . 664 .
665.
666.
667.
>PW ii
"Influence of Enzyme Induction On TCDD Toxicity", Monoqr. Giovanni Lorenzini Found, 1, 1978.
"Genetic Expression of Aryl Hydrocarbon Hydroxylase Activity in the Mouse", J. Cell. Physiol., 85, 4/75.
"Effects of Environmental Chemicals on the Genetic Regulation of Microsomal Enzyme Systems", Pharmacol. Ther., 22, 1977.
"Structural Gene Products of the Alt Locus: Genetic and Immunological Evidence For Two Forms of Mouse Liver Cytochrome P-450 Induced by 3Methycholanthrene", J . Biol. Chem., 254, 1979.
2,3,7,8-Tetrachlorodibenzo-P-Dioxin in Vitro Binding to Rat Liver Microsomes", Bull, Environ. Contam. Toxicol., 18(1), 7/77.
"A Survey of the Embryotoxic Effects of TCDD in Mammalian Species", Environ Health Perspect., 5, 9/73
"Potential Exposure of Humans to 2,4,5-T and TCDD in the Oregon Coast Range", Fundam. Appl Toxicol., 1(4) 1981.
"Exposure of Forest Herbicides to 2,3,7,8-Tetrachlorodibenzo--P-Dioxin (TCDD) in Areas Sprayed with 2,4,5T", Bull. Environ. Contam,. Toxicol., 20(6), 12/78.
"Comparison of Hyperkeratosis Induced PCBs, PCFD and PCDD Application", Fukuaka Acta Med., 66, 10/75.
"Elimination and Tissue Distribution of 2,3,7,8-Tetra chlorodibenzo-P-Dioxin (TCDD) In Female Guinea Pigs Following A Single Orazl Dose", Toxicol. Appl. Pharmacol ., 48(1), 1979.
"Biological Responses of the Nonhuman Primate, Chicken, and Rat to Chlorinated Dibenzo-P-Dioxin Ingestion", Environ. Health Perspect., 5, 9/73.
"Chlorinated Aromatic Hydrocarbon Induced Modifications of the Hepatic Endophasmic Reticulum", Environ. Health Perspect., 1, 4/72.
"Seveso: The Problems Deepen", Nature, 264(5584), 11/25/76.
-52-
1
668.
"Cytochrome P-450 Form 4, A Major Determinant of 2-Aminoanthracene Mutagenezsis", Microsomes Drug Oxid. Chem. Carci, 2, 1980.
669.
"Identification of the Major Cytochrome P-450 Form Transplacentally Induced in Neonatal Rabbits by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin", J. Biol. Chem., 253, 12/10/78.
670.
"The Toxicity of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) In Guppies (Poccilia Reticulatus Peters)", Bull. Environ. Contam. Toxicol., 12(1), 7/1974.
In addition, Monsanto refers plaintiffs to the following compendia of references responsive to this interrogatory, both of which have been produced in this litigation by the United States.
National Agricultural Library, The Toxicity of
Herbicides to Mammals, Aguatic Life, Soil
Microorganisms, Beneficial Insects and Cultivated
/-N
Plants, 1950-65:__A List of Selected References, U .S . Dep't of Agriculture, April, 1968 (i695 references).
Veterans Administration, Review- of Literature on Herbicides, Including Phenoxy Herbicides and Associated Dioxins, Veterans Administration, October, 1981 (1116 references).
INTERROGATORY NO, 8
''"V State whether you knew health hazards, physical
disorders, injuries, irritations or diseases were associated
with exposure to, or use of herbicides containing 2,4,5-T. If
your answer is affirmative, state or identify:
a) the date you acquired such knowledge, belief or suspicion;
b) the manner in which you gained such knowledge, belief or suspicion;
c) the type of health hazards, physical disorders, injuries, irritations or diseases;
-53-
4 *' ' *
Departments of Agriculture, the Interior, and Health, Education, and Welfare of the immediate suspension by USDA of certain registered uses of 2,4,5-T. Dated: New York, New York
February 17, 1984
13914
-55-
VERIFICATION
STATE OF MISSOURI ) ) ss.:
COUNTY OF ST. LOUIS )
J. R. BLEY, JR., being duly sworn, deposes and says that he is an assistant secretary of defendant Monsanto Company, a corporation; that he has read the foregoing Supplemental Answers of Defendant Monsanto Company to Plaintiffs' Interroga tories to Defendants and is familiar with the contents thereof; that deponent is without personal knowledge of the matters stated in the foregoing Supplemental Answers and is informed and be lieves that no officer or employee of Monsanto Company has personal knowledge of all such matters; that the foregoing Supplemental Answers have been assembled by authorized employees and counsel of Monsanto Company, who have informed deponent that the foregoing Supplemental Answers are true; and that to the best of deponent's knowledge those Supplemental Answers are true.
Sworn to before me this
.'cyf, February, 1984.
*?Sary P i ^ , A SCHR0EDER
NOTARY FU3LIC, STATE OF MISSOURI MY COMMISSION EXPIRES 8/29/87 Si. '|'Y _____
13915
CERTIFICATE OF SERVICE
I HEREBY AFFIRM THAT I am an attorney duly admitted to practice in the State of New York and in the Eastern District of New York. I HEREBY CERTIFY that on February 17, 1984 I caused to be served a true and correct copy of the Supplemental Answers of Defendant Monsanto Company to Plaintiffs' Interrogatories to Defendants by courier on all counsel on the attached service list.
V,
SERVICE LIST
Michael M. Gordon, Esq. Cadwalader, Wickersham & Taft One Wall Street New York, New York 10005
Leonard L. Rivkin, Esq. Rivkin, Leff, Sherman & Radler 100 Garden City Plaza Garden City, New York 11530
William Krohley, Esq. Kelley Drye & Warren 101 Park Avenue New York, New York 10178
Howard Lester, Esq. Lester Schwab Katz & Dwyer 120 Broadway New York, New York 10005
Paul V. Esposito, Esq. Lewis, Overbeck & Furman 135 South LaSalle Street Suite 1060 Chicago, Illinois 60303
David R. Gross, Esq. .Budd, L a m e r , Kent, Gross,
Picillo & Rosenbaum 33 Washington Street Newark, New Jersey 07102
Judge Morton B. Silberman Clark, Gagliardi & Miller 99 Court Street White Plains, New York 10601
Thomas Beck, Esq. Arthur, Dry & Kalish 1230 Avenue of the Americas New York, New York 10020
Richard M. Goldstein, Esq. Shea & Gould 330 Madison Avenue New York, New York 10017
L. Kenneth Sheridan, Esq. Executive' Assistant U.S. Attorney United States Attorney's Office 225 Cadman Plaza East Brooklyn, New York 11201
Stephen J . Schlegel, Esq. Schlegel & Trafelet, Ltd. One North LaSalle Street
Suite 3900 Chicago, Illinois 60602
Benton Musselwhite, Esq. Law Offices of Benton
Musselwhite, Inc. Suite 517 609 Fannin Houston, Texas 77002
Thomas W. Henderson, Esq. Baskin & Sears
Frick Building,
10th Floor Pittsburgh, Pennsylvania
15219
Victor J. Yannacone, Jr.,
Esq., Yannacone & Yannacone Post Office Drawer #109 Patchogue, New York 11772
David J. Dean, Esq. Dean, Falanga, Sinrod &
Rose One Old Country Road Carle Place, New York
11514
-.
Irving Like, Esq., Reilly, Like and
Schneider
200 West Main Street % Babylon, New York 11772 .
(
Arvin Maskin, Esq.
-
Trial Attorney, Torts
Branch, Civil Div.,
U.S. Department of
Justice
;
Safeway Building
:
Washington, D.C. 20530
V.
Clerk of Panel
Judicial Panel on
Multidistrict Litigation
1120 Vermont Avenue, N.W.
Suite 1002
.H
Washington, D.C. 20005 1 . 3 9 1 "
V* -
13818
DOCUMENT
NUMBERS
00031370ft00031391
00031391A00031414
00031414ft00031436
00031436A00031468
00031468ft00031502
00031502A00031525
SOURCE
Registration Correspondence Files of Registration Depart ment, ftg Chon Division
Registration Correspondence Files of Registration Depart ment, ftg Chem Division
Registration Correspondence Files of Registration Depart ment, ftg Chan Division
Registration Correspondence Files of Registration Depart ment, ftg Chem Division
Registration Correspondence Files of Registration Depart ment, Ag Chem Division
Registration Correspondence Files of Registration Depart ment, ftg Chem Division
FOLDER TITLE (OR OTHER FILE DESCRIPTION) Line Rider 22 Brushkiller (677-95)
Line Rider 4T Brushkiller (677-97)
Line Rider LV 3D/3T Brushkiller (677-102)
Brushkiller Dormant Cane LV 3D/3T - OS
Dormant Cane Concentrate LV-6T-OS (677-104)
Line Rider Amine 4T Brush killer (677-133)
13919
-1-
DOCUMENT NtlMRERS 00031525A00031559
00031559A00031583
00031583A00031605
00031605A00031623
00031623A00031657
00031657A00031722
03 CO o
SOURCE
Registration Correspondence Files of Registration Depart ment, Ag Chem Division
Registration Correspondence Files of Registration Depart ment, Ag Chem Division
Registration Correspondence Files of Registration Depart ment, Ag Chera Division
Registration Correspondence Files of Registration Depart ment, Ag Chem Division
Registration Correspondence Files of Registration Depart ment, Ag Chem Division
Registration Correspondence Files of Registration Depart ment, Ag Chem Division
FOLDER TITLE (OR OTHER FILE DESCRIPTION) Fence Rider 6T Brushkiller (677-136)
Line Rider LV-21 Brushkiller (677-141)
Line Rider Invert T Concentrate (677-172)
Invert D/T Concentrate (677-174)
Dacamine 4T Brushkiller (677-195)
Dacamine 2D/2T (677-196)
DOCUMENT NUMBERS 00031722A 00031795
00031795A00031799
00031799A00031806
00031806A00031810
00031810A00031822
00031822A00031827
<cUc5
SOURCE
Registration Correspondence Files of Registration Depart ment/ Ag Chon Division
Registration Correspondence Files of Registration Depart ment/ Ag Chan Division
Registration Correspondence Files of Registration Depart ment/ Ag Chen Division
Registration Correspondence Files of Registration Depart ment/ Ag Chen Division
Registration Correspondence Files of Registration Depart ment/ Ag Chen Division
Registration Correspondence Files of Registration Depart ment/ Ag Chen Division
FFTOTL.DEEDRETflIr.RTTLPETT(OONR) OTHER
Trailway 2D/2T Diamine Salt of 2,4-D and 2,4,5-T (677-238)
Technical 2-Ethylhexyl-T (677-247)
Technical Isopropyl-T (677-248)
Technical Butyl-T (677-250)
Technical Butyl-T (677-253)
Diamond Chem. 2,4,5-T Acid (677-267)
-3-
DNOT1CMURMEERNST
00031827A00031874
00031874A00031885
00031885ft00031901
00031901A00031915
00031915A00031928
00031928A 00031943
SOURCE
Registration Correspondence Files of Registration Depart ment, Ag Chan Division
Registration Correspondence Files of Registration Depart ment, Ag Chen Division
Registration Correspondence Files of Registration Depart ment, Ag Chem Division
Registration Correspondence Files of Registration Depart ment, Ag Chen Division
Registration Correspondence Files of Registration Depart ment, Ag Chen Division
Registration Correspondence Files of Registration Depart ment, Ag Chen Division
FFTOTL.DEEDRETSCITRLTEPTT(DONRi OTHER
Trailway 4T (677-273)
Technical Isooctyl Ester of Silvex (677-287)
Amine 2D/2T (677-297)
LO-VOL 2D/2T (677-301)
LO-VOL 6T (677-303)
Silvex 4-TP (677-305)
tttoOo - 4 -
DOCUMENT NUMBERS 00031943A 00031956
0003195700031958
0003195900032306
0003230700032310
0003231100032923
0003292400032945
0003294600032961
0003296200033057
Oco t oO
SOURCE Registration Correspondence Files of Registration Depart ment, Ag Chera Division
Ag Chero Registration Roan
Ag Chem Registration Rocm
Ag Chem Registration Room
Ag Chem Registration Rocm
Ag Chem Division Document Storage
Files of Diamond Shamrock Corporate Insurance Department
Files of Diamond Shamrock Corporate Insurance Department
-5-
FOLDER TITLE (OR OTHER FILE DESCRIPTION) LO-VCL (677-306)
Phenoxy - Flash Point
Phenoxy Miscellaneous
2,4-D General
2,4,5-T Silvex
Contract Formulations
Workmen's Compensation Newark - 1971-72 Workmen's Compensation Claims - Newark Plant Chloracne
DOCUMENT
NUMBERS . 0003305800033108
0003310900033318
0003331900033334
0003333500033812
0003381399934311
00034311A00034421
0003442200034722
SOURCE
Files of F.R. Kenned/
Files of F.G. Steward
POLDER TITLE (OR OTHER
FILE DESCRIPTION)___ Personnel
Newark - Workmen's Compensation
Diamond Shamrock Law Dept.
Files of Diamond Shamrock Agrochemicals Ltd.
Files of Diamond Shanrock Agrochemicals Ltd.
Files of Diamond Shamrock Agrochemicals Ltd.
Files of Diamond Shamrock Agrochemicals Ltd.
-6-
Environmental Health: New Jersey State Dept, of Health Survey of Former Newark Plant Personnel
2,4,5-T Files of David H. Spranklin
2,4,5-T
2,4,5-T Fils from Bob Beale
2,4,5-T Files fran R.E. Snell
DOCUMENT
NQMBEBS0003472300036221
SOORCE Files of Diamond Shamrock Agrochemicals Ltd.
FFOILLEDEDRETSECIRLIEPTI(OONR) COD_ER
2,4,5-T Files from Betts Wood Offices
AFFIDAVIT OF SERVICE
STATE OF NEW YORK ) : ss.:
COUNTY OF NEW YORK )
JEFFREY SAPER, being duly sworn, deposes and says:
1. I am not a party to this action, am over 18 years of age and reside in Queens County, New York.
2. On March 6, 1984, I served the annexed Defendant Diamond Shamrock's Index of Additional Documents Available for Inspection and Copying in Post-Phase I Discovery, Dated March 6 1984 on each of the persons named on the annexed list by deposi ting a true copy of same enclosed in a postpaid properly ad dressed wrapper, in an official depository under the exclusive care and custody of the United States Postal Service within the State of New York. A copy was also sent by Federal Express to the Agent Orange Plaintiffs' Management Committee, 26 Court Street, Suite 905, Brooklyn, New York 11242, and to Victor Don Russo, Jr., Esq., 7 Bonnie Drive, Northport, New York 11768.
Sworn to before me this 4 - K day of March, 1984.
CoinpQmjnn.ilHMtitoomndNEBoinx.vpn3Ni1re-e4ws64MY59oa9rr6kchC3o0u.,n1t9y.a0.--r -
1
semer list
roe defendants
Leonard L. Rivkin Rivkin, Leff, Sherman & Radier
(for DOW CHEMICAL) 100 Garden City riera Garden City, New York 11530
Morton G. Silbernen Clark, Gagliardi 4 Miller
(for T H AGRICULTURE & NUTRITION COMPANY, INC.) The Inna of Court 99 Court Street White Pleine, New York 10601
John C. Sabetta Townley 4 Updike
(for MONSANTO) 405 Lexington Avenue New York, New York 10174
William Krohley Xelley Drye 4 Warren
(for HERCULES, INC.) 101 Park Avenue New York, New York 10178
John M. Fitzpatrick Dilworth, Paxson, Xaliah 4 L e w
(for HOOKER PLASTICS 4
CHEMICALS CORP.) 2600 The Fidelity Building Philadelphia, Pennaylvania 19109
Richard Goldstein Shea 4 Gould 330 Madison Avenue New York, New York
10017
Thomas Seek Arthur, Dry 4 Relish, P.C.
(for UNIROYAL) 1230 Avenue of the Americas New York, New York 10020
David R. Gross Budd, Larner, Kent, Gross, Pieillo 4 Rosenbaum
(for THOMPSON CHEMICALS) 33 Washington Street
Newark, New Jersey 07102
Arvin Maskin Department of Justice
(for THIRD PARTY DEFENDANT USA) Safeway Building 521 12th Street, N.W. Washington, D.C. 20530
L. Kevin Sheridan Executive Assistant
U.S. Attorney Eastern District of New York United States Courthouse 225 Cadman Plaza East Brooklyn, New York 11201
COPIES OF ALL DOCUMENTS MUST BE 5EXT TO:__________ _
Clerk of the Panel Judicial Panel on Multidistrict
Litigation 1120 Vermont Avenue, N.W. Suite 1002 Washington, D.C. 20005
TOR PLAINTIFFS
Victor J. Yannaeone, Jr. Yannacone 4 Yannaeone Post Office Drawer <109 Patchogue, New York 11772
Stephen J. Schlegel Schlegel 4 Trafelet, Ltd. One North LaSalle Street Suite 3900 Chicago, Illinois 60602
Benton Musselwhite Law Officvof Benton Musselwhite,
Inc. Suite 517 609 Fannin Houston, Texas 77002
Thomas Henderson Baskin 4 Sears Frick Building - 10th Tloor Pittsburgh, Pennsylvania 15219
David J. Dean, Esq. Dean, Falange 4 Rose 1 Old Country Road Carle Place, New York 11514'
i&xzcduxzdxder','l^ccA e^ uon/&
A PA R T N E R S H IP IN CLU D IN G PR O FE S S IO N A L C O R PO R A TIO N S
1 3 3 3 N E W H A M P S H IR E A V E , N .' W A S H IN G T O N , D .C . 2 0 0 3 6 (202) 2 9 3 - 6 3 0 0 TW X: 7 IO - 6 2 2 - l 3 4
J f% /.S 0 0 0 5
S fy jic n * : ( * 2 ) 0 0 6 -7 0 0 0
2 4 R O YA L PA LM WAY PALM REACH , FLA. 3 3 4 6 0
(30S ) 6 6 3 -9 6 0 0 TW X: S IO * 9 3 2 * 7 6 2 6
CABLE AD D RESS: LABELLUM t e l e x : 12 1 4 6 / 6 9 7 4 6 5
R A P IF A X : (212) 2 6 9 - 2 3 2 1 X E R O X : (212) 7 6 6 * 1 6 3 0
, March 6, 1984
Stephen J. Schlegel, Esq. Agent Orange Plaintiffs'
Management Committee 26 Court Street Brooklyn, New York 11242
Re: In re "Agent Orange" Product Liability Litigation, MDL No. 381
Dear Stephen:
I enclose Diamond Shamrock's Index of Additional Documents Available for Inspection and Copying in Post-Phase I Discovery, Dated March 6, 1984. The documents referenced by the Supplemental Index are available for microfilming or, as plaintiffs have done in the past, for review at our offices to identify those documents you would like to order.
The documents included in Diamond Shamrock's postPhase I production consist almost entirely of two categories of material. First, over half the documents. (Doc. Nos. 00033335-36221) are files from Diamond Shamrock Agrochemicals Ltd. which were forwarded'to us from the United Kingdom. As explained in the Responses of Defendant Diamond Shamrock Chemicals Company to Plaintiffs' Interrogatories to Defendants, served on January 16, 1984, Agrochemicals' plant never manu factured trichlorophenol, but did produce some herbicides con taining 2,4,5-T, using 2,4,5-T acid purchased from another party. However, Agrochemicals' operations were only acquired by a sub sidiary of Diamond Shamrock on December 1, 1977. Accordingly, while the Agrochemicals documents may arguably be responsive to
13928.
S t e p h e n J. S c h l e g e l , Esg.
-2 - March 6, 1984
one of plaintiffs' earlier document requests in this litiga tion, you may wish to review the Agrochemicals documents at our offices before ordering copies of them.
Virtually all of the remaining documents referenced by the Index are from the second category, which consists of post-1970 materials that might otherwise be responsive to plaintiffs' Interrogatories to Defendants (First Wave), dated April 19, 1983. Since these documents did not pertain to the relevant time period for the government contract defense, they were not produced as part of Phase I discovery.
Pursuant to the Court's protective order dated Febru ary 6, 1981, we will serve within the next several days a Notice
of Confidentiality and Updated Index of Confidential Documents
that identifies the documents referenced by the enclosed Index which Diamond Shamrock has designated as "Confidential".
If you have any questions concerning the documents referenced by the Index, please contact me at your earliest convenience.
Very truly yours,
MMG/mam Enclosure
Michael M. Gordon
BY COURIER
cc(w/encl.):
Clerk of the Court Magistrate Shira A. Scheindlin Service List Victor Don Russo, Jr., Esq.
13929
<\ -
UNITED STATES DISTRICT COURT EASTERN DISTRICT OF NEW YORK
X
In Re "AGENT ORANGE"
Product Liability Litigation
X
Defendant The Dow Chemical Company's Amended Answers to Plaintiffs' Interrogatories to Defendants_ _ _ _ _
In accordance with Magistrate's Pretrial Order No. 2 dated
February 10, 1984, defendant The Dow Chemical Company ("Dow") hereby amends its Answers and Objections to Plaintiffs' Interrogatories to
Defendants dated January 16, 1984. Dow reserves its right to supple ment or to amend further its answers as Dow acquires additional infor
mation in the course of its continuing preparations for trial. Dow also reserves all objections to the admission in evidence of its answer or the subject matter thereof in any proceeding or trial in this or any other action.
Schedules of documents produced in response to Interroga
tories 2, 3, 4, 5, 9, and 10 are attached as Exhibits A, B, C, D, E,
and F, respectively. In addition, the answers to Interrogatories 8 and 11 are
amended as follows: Interrogatory 8
State whether you knew health hazards, physical disorders injuries, irritations or diseases were associated with exposure to, or use of herbicides containing 2,4,5-T. If your answer is affirmative,
state or identify:
13930
a) the date you acquired such knowledge, belief or suspicion;
b) the manner in which you gained such knowledge belief or suspicion;
c) the type of health hazards, physical disorders, injuries, irritations or diseases;
d) all documents and communications which refer, reflect, relate to, or embody the information sought by this interrogatory.
Answer
Dow knows of no health hazards, physical disorders, injuries, irritations, or diseases associated with exposure to or use of its herbicides containing 2,4,5-T when used as directed.
Interrogatory 11
Did you at any time between 1961 and 1973 recommend to the government that any herbicide containing 2,4,5-T be replaced because of possible health problems associated with its use?
Answer
No
Dated: Garden City, New York February 17, 1984
RIVKIN, LEFF, SHERMAN & RADLER for the Dow Chemical Company
(A Member oo f the Firm) 100 Garden City Plaza Garden City, New York 11530 (516)746-7500
3 9 3 1
Dow Docum ents R esp o n siv e t o C a u sa tio n In te r r o g a to r y 2
DOW0022120 DOW0023058-0023060 DOW00359 73 DOW0038002-0038003 DOW0038004 DOW0038347-0038348 DOW0040310-0040311 DOW0040324 DOW0045028 DOW0045665 DOW0045667-0045668 DOW0229696 DOW0333791-0333836 DOW0382816 DOW0446119-0446120 DOW0446121 DOW0446122 DOW0446123 DOWO587486-0587489 DOW0587502 DOW0587550 DOW0587690 DOW0775003- 0775007 DOW0775008-0775014 DOW0901792
DOW1162289
1393?
DOW1474553-1474555 DOWl552165-1552173 DOW1601589-1601593 DOW1601862 DOW1601864-1601865 DOW1601872-1601873 DOW1716325 DOWl749939-1749940
Dow Documents Responsive to Causation Interrogatory 3
DOW0183335-0183336 DOW0312587 DOW0363666 DOW0363668 DOW0363676 DOW0363678 DOW0363689 DOW0363691 DOW0363699 DOW0363707 DOW0363709-0363710 DOWO 363827-0363840 DOW037739 7 DOW0377398 DOW0377399 DOW0377400 DOW0377401 DOW0377402 DOWO378502-0378505 DOW0428299-0428302 DOWO438023-0438024 DOWO438042-0438054 DOW0438163 DOWO438261-0438262 DOWO438281-0438294
DOW0439197
13934
DOW0439200 DOW0439206 DOW0439251 DOW0439254 DOW0439309 DOW0439311 DOWO439344 DOW0439346 DOW0439348 DOWO439355 DOW0439357 DOW0439359 DOW0439361 DOW0439369 DOW0439372 DOW0439382 DOW0439384 DOW0439392 DOW0439396 DOWO439399-0439400 DOW0439407-0439408 DOW0439410 DOWO 500580-0500584 DOWO 521676-0521678 DOWO521934-0521936 DOWO521971-0521973 DOW0523812 DOW0524022
DOW0525786
-13935
i9
'S .
DOW525791 DOWO5 2 5 8 2 2 -O525823 DOWO5 2 5 8 2 5 - 0 5 2 5 8 2 6 DOWO5 2 5 9 0 8 - 0 5 2 5 9 0 9 DOWO5 2 5 9 1 1 - 0 5 2 5 9 1 2 DOWO5 2 5 9 6 3 - 0 5 2 5 9 6 4 DOWO5 2 5 9 6 6 - 0 5 2 5 9 6 7 DOWO5 2 5 9 9 9 - 0 5 2 6 0 0 0 DOW0526020-0526029 DOWO5 2 6 0 3 2 - 0 5 2 6 0 4 1 DOWO5 3 4 6 8 7 - 0 5 3 4 6 8 8 DOWO5 3 5 9 4 5 - 0 5 3 5 9 4 6 DOWO535949 DOWO5 3 6 5 9 1 DOWO5 3 6 6 6 5 - 0 5 3 6 6 6 6 DOW0536797 DOWO5 3 6 8 0 6 - 0 5 3 6 8 0 7 DOWO5 3 6 8 4 9 - 0 5 3 6 8 5 0 DOWO5 3 6 8 6 1 DOWO5 3 6 8 9 4 - 0 5 3 6 8 9 5 DOW061 8 7 3 4 - 0 6 1 8 7 3 6 DOWO7 2 0 1 7 1 - 0 7 2 0 1 7 4 DOWO7 2 1 7 4 4 - 0 7 2 1 7 5 3 DOWO7 2 1 7 5 5 - 0 7 2 1 7 5 6 DOWO8 1 7 3 4 4 - 0 8 1 7 3 5 0 DOWO8 2 0 3 8 6 - 0 8 2 0 3 9 2 DOW0820969 DOW820976-820977
DOW821214-0821216
-3-
1t 3^ 9^ 3 g
DOWO821224-0821233 DOWO821252-0821259 DOW0821281 DOW0821292-0821294 DOW,0853510-0853511 . DOWO853513-0853514 DOW0930305-0930307 DOWO930798-0930800 DOWO937219-0937220 DOW1171625 DOWl171626-1171627 DOW1171633 DOW1171634 DOW1171635 DOW1171637-1171639 DOW1171640 DOW1406308 DOW1406312 DOW1406342 DOW1962461 DOW1992285 DOW2022546-2022547
-4-
H/9
DOW DOCUMENTS RESPONSIVE TO CAUSATION INTERROGATORY 4
DOW0011959 DOWOO32302-0032324 DOWO032707-0032713 DOW0282117 DOWO556228-0556230
DOW DOCUMENTS RESPONSIVE TO CAUSATION INTERROGATORY 5
DOWO171108-0171111 DOWO171112-0171115 DOW0274515-0274517 DOW0441623-0441624 DOWO731412-0731414 DOW1320042-1320044 DOWO345368-1345370 DOWl421577-1421583 DOW1520974-1520978 DOW1587601-1587609
Dow Documents Responsive to Causation Interrogatory 9
DOW0091999 DOW0037484-0037485 DW0101686-0101694 DOW0105153-0105167 DOW0120640-0120663 DOW0121686-0121688 DOW0203438-0203446 DOW0271733-0203757 DOW0273187-0273200 DOW0274755-0274757 DOW0280618-0280632 DOW0341469 DOW0379469 DOW0363570-0363575 DOW0376087 DOW0383682-0393685 DOW0390506-0390507 DOW0396891 DOW0442260-0442261 DOW0442329--00442333 DOW0445868-00445877 DOW0804169-0804183 DOW0947878--0947885 DOW1155346--1155350 DOW1172151--1172159 DOW1172171--1172185
DOW1172160-1172170
1
DOWll72854-1172855 DOW1172857 DOW1172871 DOW1172872 DOW1172883 P9^1172886 DOWl377253-1377331 DOW1519607-1519616 DOW1544160-1544161
-2 - 13941
D O W DOCUMENTS RESPONSIVE TO CAUSATION INTERRORAGATORY 10
DOWOO23737-0023762 DOWO023948-0023963 DOW0273805-0273809 5W0281777-028177 8 DOWO384279-0384291 DOWO397546-0397573 DOWO397627-0397629 DOW0414141-0414145 DOW0856323-0856324 DOW0914690-0914692 DOW0992595-0992517 DOWl603607-1603608 DOW16 03609 DOWl613599-1613641
VERIFICATION LESLIE R. BENNETT, being duly sworn, deposes and says: 1. I am a member of the firm of RIVKIN, LEFF, SHERMAN & RADLER, attorneys for The Dow Chemical Company, a defendant in the above-entitled action, and I am the agent of that corporation for the purpose of answering the interrogatories served upon the corporation by plaintiffs on December 22, 1983 and for making this verification. 2. I have read the said interrogatories and the fore going answers thereto are true according to the best of my knowledge, information and belief.
Sworn to before me this 17th day of February, 1984.
Notary Pub
'!*as!csS**Y'*
STATE OF NEW YORK COUNTY OF NASSAU
)
)
)
Sharon A. Vento, being duly sworn, deposes and says:
deponent is not a party to the action, is over 18 years of age and
resides at Oceanside, N.Y.
On February 17,
19 84 , deponent served the with.in
Defendant The Dow Chemical Company's Amended Answers to Plaintiffs'
Interrogatories to Defendants upon the attorneys below set forth represent
ing the parties, as indicated, at the addresses shown, said addresses
being designated by said attorney for that purpose.
ATTORNEY: SEE ATTACHED SERVICE LIST
by depositing a true copy of same enclosed in a postpaid properly addressed wrapper in an official depository under the exclusive care and custody of the United States Post Office Department within the State of New York.
S/w7o*r*ndatyo
before of
me
this
,
19
5 A .(ja^r--
Notary
Term(pires March30, 19^
Rivkin, Leff, Sherman & Radler
TO:
MORTON B. SILBERMAN, ESQ. Clark, Gagliardi & Miller The Inns of Court 99 Court Street White Plains, NY 10601
WENDELL B. ALCORN, JR., ESQ. Cadwalader, Wickersham & Taft One Wall Street New York, NY 10005
JOHN SABETTA, ESQ. Townely & Updike 405 Lexington Avenue New York, N.Y. 10174
WILLIAM KROHLEY, ESQ. Kelley, Drye & Wareen 101 Park Avenue New York, NY 10178
DAVID R. GROSS, ESQ. Budd, Larner, Kent, Gross,
Picillo & Rosenbaum 33 Washington Avenue Newark, NJ 07102
THOMAS A BECK, ESQ. Arthur, Dry & Kalish, P.C. 1230 Avenue of the Americas New York, NY 10020
ARVIN MASKIN, ESQ. Department of Justice Safeway Building Room 904D Washington, DC 20530
JUDY SPANIER, ESQ. Shea & Gould 330 Madison Avenue 15th Floor New York, NY 10017
PAUL ESPOSITO, ESQ. Lewis, Overbeck & Furman 135 South LaSalle Street Suite 1060 Chicago, IL 60603
HOWARD LESTER, ESQ. Lester, Schwab, Katz & Dwyer 120 Broadway New York, NY 10271
STEPHEN J. SCHLEGEL, ESQ. Schlegel & Trafelet, LTD. One North LaSalle Street Suite 3900 Chicago, IL 60602
BENTON MUSSELWHITE, ESQ. Suite 517 609 Fannin Houston, Texas 77002
THOMAS HENDERSON,. ESQ. Baskin & Sears Frick Building - 10th Floor Pittsburgh, PA 15219
VICTOR J. YANNACONE, ESQ. Yannacone & Yannacone 35 Baker Street P.O. Box 109 Patchogue, NY 11772
DAVID DEAN, ESQ. Dean, Falanga & Rose One Old Country Road Carle Place, NY 11514
SOL SCHREIBER, ESQ. Special Master Milberg, Weiss, Bershad
& Specthrie One Pennsylvania Plaza Room 4915, 49th Floor New York, NY 10019
Clerk of the Panel Judicial Panel on Multidistrict
Litigation 1120 Vermont Avenue, N.W. Suite 1002 Washington, DC 20005
Magistrate Shira A. Scheindlin United States District Court Eastern District of New York 225 Cadman Plaza East Brooklyn, NY 11201
Agent Orange Plaintiffs' Management Committee
Suite 905 Brooklyn, NY 11242
LAW O FFIC ES
R ivkin, Leff, Sherman & Radler lOO GARDEN" CITY PLAZA
GARDEN" CITY, NEW YORK 1 1 3 3 0
TELEPHONE (5IS) 746 * 75 0 0
TELEX 8 45-074
CA8LE ADDRESS ATIAW GRCY
TE LE C O P IE R (5 1 6 )7 4 7 -2 8 4 3
SUITE 3 9 0 0 *30 NORTH LA SALLE STREET CHICAGO , ILLINOIS 6 0 6 0 2 - ( 3 l2 ) 7 8 2 - 5 6 8 0
228-4291W R IT E R S D IR E C T d ia l : ( s i 6 )
March 2, 1984
V
Clerk United States District Court Eastern District of New York US Courthouse 225 Cadman Plaza East Brooklyn, NY 11201
Re: Agent Orange Product Liability Litigation MDL No. 381
Dear Sir or Madam:
I-.-encl.pse-for filing in the above-captioned litigation'The Dow Chemical Company's Amended Answers to Plaintiffs' Interroga tories to Defendants which were served on all parties on February 17, 1984.
Thank you for your cooperation.
Very truly yours,
RIVKIN, LEFF, SHERMAN & RADLER
Steven Brock
SB:clb
Enclosure
cc: Attached Service List w/o enclosures
THE P AR TN E R S H IP INCLUO ES ONE O R M ORE P R O FE S S IO N A L CORPORATIONS
Rivkin, Le ff, S herm an & Radler
TO:
Morton B. Silberman, Esq. Clark, Gagliardi & Miller The Inns of Court 99 Court Street White Plains, NY 10601
Wendel B. Alcorn, Jr., Esq. Cadwalader, Wickersham & Taft One Wall Street New York, NY 10005
Howard Lester, Esq. Lester, Schwab, Katz & Dwyer 120 Broadway New York, NY 10271
Stephen J. Schlegel, Esq. Schlegel & Trafelet, Ltd. One North LaSalle Street Suite 3900 Chicago, IL 60602
John Sabetta, Esq. Townley & Updike 405 Lexington Avenue New York, NY 10174
William Krohley, Esq. Kelley, Drye & Warren 101 Park Avenue New York, NY 10178
David R. Gross, Esq. Budd, Larner, Kent, Gross, Picillo & Rosenbaum 33 Wshington Avenue Newark, NJ 07102
Thomas A. Beck, Esq. Arthur, Dry & Palish . 1230 Avenue of the Americas New York, NY 10020
Arvin Maskin, Esq. Department of Justice Safeway Building Room 904 D Washington, DC 20530
Judy Spanier, Esq. Shea & Gould 330 Madison Avenue 15th Floor New York, NY 10017
Paul Esposito, Esq. Lewis, Overbeck & Furman 135 South LaSalle Street Suite 1060 Chicago, IL 60603
Agent Orange Plaintiffs' Management Committee 26 Court Street Suite 905 Brooklyn, NY 11242
Benton Musselwhite, Esq. Law Offices of Benton Musselwhite, Suite 517 609 Fannin Houston, TX 77002
Thomas Henderson, Esq. Baskin & Sears Frick Building - 10th Floor Pittsburgh, PA 15219
Victor J. Yannacone, Jr., Esq.
Yannacone & .Yannacone
P.O. Box 109
35 Baker Street
_
Patchogue, NY 11772
David Dean, Esq. Dean, Falanga & Rose One Old Country Road Carle Place, NY 11514
Sol Schreiber, Esq. Special Master Milberg, Weiss, Bershad & Specthrie One Pennsylvania Plaza Room 4915, 49th Floor New York, NY 10019
Clerk of the Panel Judicial Pane'l on Multidistrict Lit 1120 Vermont Avenue, NW Suite 1002 Washington, DC 20005
Magistrate Shira A. Scheindlin United States District Court Eastern District of New York 225 Cadman Plaza East Brooklyn, NY 11201
13947
R ivkin, Leff, S herm an & Radler
Service List Page 2
Phillip E. Brown, Esq. Hoberg, Finger, Brown, Cox & Molliga 703 Market Street 18th Floor San Francisco, California 94103
Stanley Chesley, Esq. Waite, Schnider, Bayleff & Chesley
1218 Central Trust Tower Cincinnati, Ohio 45202
John Q. O'Quinn, Esq. O'Quinn, Hagans & Wettman 3200 Texas Commerce Tower Houston, Texas 77002
Neal R. Peterson, Esq. and Gene Locks, Esq.
Greitzer & Locks 1500 Walnut Street 22nd Floor Philadelphia, Pennsylvania
19102
Newton B. Schwartz, Esq. Houston Bar Center Building 723 Main Suite 325 Houston, Texas 77002
s
UNITED STATES DISTRICT COURT EASTERN DISTRICT OF NEW YORK
In re "AGENT ORANGE"
X
NOTICE OF CONFIDENTIALITY AND UPDATED INDEX OF CONFIDENTIAL DOCUMENTS OF DEFENDANT THE DOW CHEMICAL COMPANY
Product Liability Litigation
MDL No. 381 (GCP) (All Cases)
X
Defendant, The Dow Chemical Company, ("Dow"), pursuant to
the Protective Order regarding Production of Confidential
Documents by Defendants dated February 6, 1981 (the "Confiden
tiality Order"), annexes hereto a Notice of Confidentiality
(Exhibit A) and an Updated Index of Confidential Documents
(Exhibit B) for those documents referenced in the Defendant The
Dow Chemical Company's Answers to Plaintiffs' Interrogatories to
Defendants (First Wave), dated February 13, 1981, which Dow has
designated as "CONFIDENTIAL."
In accordance with paragraph 14 of the Confidentiality Order,
Dow reserves its right to prepare and distribute further notices
of confidentiality and indexes as the need arises, and to avail
itself of the procedures set forth in the Confidentiality Order
for the documents identified therein.
Dated: Garden City, New York March 1, 1983
RIVKIN, LEFF, SHERMAN & RADLER
By : A Member ot the Firm
Attorneys for The Dow Chemical Company 100 Garden City Plaza TO: ATTACHED SERVICE LIST Garden City, N.Y. 11530
(516) 746-7500
NOTICE OF CONFIDENTIALITY AND UPDATED INDEX OF CONFIDENTIAL DOCUMENTS OF THE DOW CHEMICAL COMPANY
NOTICE OF CONFIDENTIALITY
w)
)
Dow Number
00883470088348*
00883490088350*
00886490088650*
Date 701217
701217 590122
0088651 *
00889110088913*
590500 660506
00889140088916*
00889300088962*
00889690088972*
771001 661209 670316
00889730089003*
690515
Author
Recipient
Dow Hoyle, HR Norris, JM
Dow Norris, JM
Dow Hoyle, HR McCollister, DD
Wolf, MA
Dow
Dow Hoyle, HR McCollister, DD Olson, KJ
Dow
Dow
Dow Hoyle, HR Olson, KJ Oyen, F
Buerge, TE Dow
m
) )
Distributees
Page 1
General Subject Matter
M-3592 (Data sheet of properties, health hazards, and precautions for safe handling of materials)
M-32592 (Medical Information)
Forron Brush K ille r (Data sheet of properties health hazards and pre cautions for safe handling of materials)
Forron Brush K ille r M-1368, Safety data sheet
M-2993 (Data sheet of properties, health hazards, and precautions for safe handling of materials)
Tordon 155 Mixture Brush K ille r (Material safety data sheet)
2M0-3083-1 (Request for screening or application testing)
Tordon 105 Mixture (Data sheet of properties, health hazards, and precautions for safe handling of materials)
Toxicological properties and Industrial handling hazards of
Dow Number
Date
00911730091176*
670316
Author
Norris, JM Torkelson
Buerge, TE Dow Lynn, GE Olson, K Oyen, F
Recipient
00911770091178*
670227
Dow Hoyle, HR Olson, KJ Oyen, F
f
Distributees
Boundy, RH Dean, P Dow Elshere, D Holder, BB Jones, GD Kagy, JF K1l1an, DJ Luce, EN Lynn, GE McIntyre, HH Moss, RD Sheetz, DP Shrader, SA Wilson, AW Wright, N
Boundy, RH Dean, P Dow Elshere, D Holder*, BB Jones, GD Kagy, JF K1l1an, DJ Luce, EN Lynn, GE McIntyre, HH Moss, RD Sheetz, DP
to
IO
C2O
General Subject M atter^
Page
Tordon 225 Mixture herbicide (M-3199X)
Toxicological properties and
Industrial handling hazards of Tordon 105 Mixture (T2.M031-3132-1) (CRI 123032)
Tordon 105 Mixture data sheet of properties, health hazards, and
precautions for safe handling of materials (T2.MO-3132-1)
Dow Number
02783850278390*
02783900278392*
02783930278395*
02783960278404*
0503923 *
05648500564851*
Date 540106 531230 540106 540106
000000 000000
07251790725184*
07503320750354*
650615 571122
Author
Dow Wolf, MA
Recipient
Dow
Dow Hoyle, HR JMN
Dow
Dow McColHster DO Olson, KJ
M
" (CO)
CCJ7X5
Distributees
A llln son, RL Athay, RN Beshgetoor, AW Boundy, RH Colby, RW Dosser, RC Dow
Page 3 General Subject Matter
M-213 (Acute oral toxicity)
M-213 (Acute oral toxicity)
M-213
M-213 (Skin Irrita tio n )
Esteron 76BE
Tordon 225 herbicide (Data sheet of properties, health hazards, and precautions for safe handling of materials)
Pulsafeeder test sheet hydroch lo ric acid
Results of range finding toxicolo gical tests on Brush K ille r X, Weed K ille r X, and Brush K ille r TX
I
)
Dow Number
Date
Author
Recipient
07504650750469*
501017
07504700750484*
530217
Adams, EM
Dow M cCollister, DD Rowe, VK
Allen, WW Alquist, FN Britton, JW Dosser, RC
Dow Dutton, WC Irish , DD Kagy, JF Lynn, GE
Dow RJE M cCollister, DD Oyen, F
<05}
"si
)
)
Distributees
Elshere, D Gay, HH Greene, LM Hart, A Hymas, TA Jones, GD K ilia n , DJ Luce, EN Martin, D McIntyre, HH Mussel!, DR Perkins, RP Tisdale, WO White, LC Wright, N
General Subject Matter
Page 4
Results of skin irrita tio n and
skin sensitization tests conducted on human subjects with Esteron 245 (New Ester)
Allen, WW
Allinson, RL Alquist, FN Beshgetoor, AW Boundy, RH Britton, EC
Results of range finding toxicolo gical tests on Esteron 245
Dow Number
Date
Author
Recipient
07505600750587*
531030
Adams, EN
Oyen, F
);
)
Distributees
Britton, JW Collier, B Davidson, JH Dow Dutton, WC Gay, HH Gibson, J Greene, LN Heath, SB Johnson, JE Kagy, JF Kelly, JA Kriner, RR Luce, EN Lynn, GE MacCutcheon Melass, VH Nation, HA Otis, CE Prendergast, DT Southwick, L Sunderland, WW Vanhorn, JC Walker, H White, LC Wright, P Zuhl, HH
Allen, WW Alllnson, RL Alqulst, FN Barrons, KC Beshgetoor, AW
General Subject Matter
Page 5
Results of range finding toxicolo gical tests on Dow Brush K ille r T
)
Dow Number
Date
Author
Recipient
07506020750633*
560501
Dow M cColllster, DD Torkelson, TR
13959
)
Distributees
Boundy, RH Britton, EC Davidson, JH Dow Dutton, WC Gay, HH Greene, LM Kagy, JF Luce, EN Lynn, GE MacCutcheon, SM Prescott, RF Sunderland, WW White, L Wright, P
AlUnson, RL Beshgetoor, AW Boundy, RH Britton, EC Coulter, LL Dow Elshere, D Gay, HH Greene, LM Hart, A K ilia n , DJ Luce, EN McCutcheon, SM Martin, D Scoles, G Sunderland, WW Wright, N
General Subject Matter
Page 6
Results of range finding toxicolo gical tests on M-631 (Esteron 245-Type Formulation)
*
II
}
Dow Number
07506660750693*
Date 560409
Author
Recipient
Dow M cCollister, DD Wolf, MA
07506940750714*
560702
Dow M cCollister, DD Olson, KJ
O0CC5OO
)
Distributees
AlHnson, RL Beshgetoor, AW Boundy, RH Britton, EC Colby, RW Dow Elshere, D Gay, HH Greene, LM Hart, A Kagy, JF Kelly, J K111an, DJ Luce, EN Lynn, GE MacCutcheon, SM Sunderland, WW Wright, N
Alllnson, RL A lqulst, FN Barrons, KC Beshgetoor, AW Boundy, RH Britton, EC Colby, RW Dow Elshere, D Gay, HH Greene, LM Hart, A Kagy, KF K e lly, JA
Page 7 General Subject Matter Results of range finding toxicolo gical tests on formulations of Reddon (M-640 and M-713)
Results of range finding toxicolo gical tests on Esteron Brush K ille r O.S. (M-726)
Dow Number
Date
Author
Recipient
07507190750726*
570806
Dow Hoyle, HR Wolf, MA
07507270750736*
570510
Babcock, I Dow Dunn, EE
Dow Wolf, MA
co
0C5O
;
J
Distributees
K ilia n , DJ Luce, EN Lynn, GE MacCutcheon, SM Sunderland, WW Wright, N
Allinson, RL Athay, RM Beshgetoor, AW Boundy, RH Colby, RW Dow Eishere, D Gay, HH Greene, LM Hart, A Jones, GD Kagy, JF K ilia n , DJ Luce, EN Lynn, GE M cCollister, DD McIntyre, HH Musseil, DR Perkins, RP Scoles, GW Tisdale, WL Wright, N
General Subject Matter
Page
Results of rant* finding toxicolo glcal tests on N-1085 (A 245T Triethyl amine Liquid Formulation)
Request for application testing for M-1085 with eye and skin contact tests attached
)
Dow Number
Date
07507390750740*
570510
07507410750743*
000000
07507440750746*
580521
07507470750764*
580425
Author
Recipient
KS MAW
Dow Hoyle, HR McCollister, DD
Wolf, MA
Dow Hoyle, HR McCol lis t e r , DD Wolf, MA
Dow Coulter, LL McCollister, DD Dow
Olson, KJ
Dow Hoyle, HR McCollister, DD
Olson, KJ
CO 0C3D
II
I
D1strlbutees
General Subject Matter
Page 9
AlUnson, RL Athay, RM Beshgetoor, AW Boundy, RH Colby, RW Coulter, LL Dow Elshere, D Fletcher, FW Gay, HH
Greene, LM Hammer, OH Hart, A Jones, GD Kagy, JF
M-1085 data sheet of properties, health hazards, and precautions for safe handling of materials
M-1085 data sheet of properties, health hazards, and precautions for safe handling of materials
Results of range finding toxicolo gical tests on Weed K ille r Formulation M-1094 containing a 245T Ester
M-1094 Weed K ille r Formulation Data sheet of properties, health hazards and precautions for safe handling of materials
I )
Dow Number
Date
Author
Recipient
07507690750790*
610316
Hoyle, HR
Olson, KJ Oyen, F Thompson, E
07507910750793*
CCKOo* CO
000000
Hoyle, HR Olson, KJ Oyen, F
Distributees
K1l1an, DJ Luce, EN McIntyre, HH Perkins, RP Scoles, GW Tisdale, WL Vanvalkenburg, W Wright, N
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Falkensteln, WJ Gay, HH Greene, LM Hart, A Jones, GD Kagy, JF K1l1an, DJ Luce, EN Lynn, GE McIntyre, HH Perkins, RP Shrader, SA Tisdale, WL Vanvalkenburg, W Wright, N
General Subject Matter
Page 10
Results of range finding toxicolo gical tests on M-1123
V. T
M-1123 data sheet of properties, health hazards, and precautions for safe handling of materials
Dow Number
07507950750813*
Date 600125
Author
Dow Oyen, F Wolf, MA
Recipient
07508140750827*
610601
Dow Olson, KJ Oyen, F
/
Distributees
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Gay, HH Greene, LM Hammer, OH Hart, A Hymas, TA Jones, GD Kagy, JF K ilia n , DJ Luce, EN Lynn, GE McIntyre, HH Perkins, RP Stenger, VA Tisdale, WL Wright, N
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Falkenstein, WJ Gay, HH Greene, LM Hart, A Jones, GD Kagy, JF K1l1an, DJ
Page 11 General Subject Matter Results of range finding toxlcolo glcal tests on Esteron 245 OS (M--1257)
Results of range finding toxicolo gical tests on Esteron 245 OS (Replacement for present Formulation M-1257)
V *
}
Dow Number
Date
Author
Recipient
07508330750854*
571122
Dow McColHster, DD Olson, KJ
^ 0750855Co 0750873* CD
CJ?
590818
Olson, KJ Oyen, F
)) )
Distributees
Luce, EN Lynn, GE McIntyre, HH Perkins, RP Shrader, SA Tisdale, WL Whlte, LC, J r. Wright, N
AlUnson, RL Athay, RM Beshgetoor, AW Boundy, RH Colby, RW Dosser, RC Dow Elshere, D Gay, HH Greene, LM Hart, A Hymas, TA Jones, GD K111an, DJ Luce, EN Martin, D McIntyre, HH Mussell, DR Perkins, RP Tisdale, WL White, LC Wright, N
Barrons, KC Boundy, RH
General Subject Matter
Page 12
Results of range finding toxicolo
gical tests on Brush K ille r X, Weed K ille r X, and Brush K ille r TX
Results of range finding toxicolo gical tests on M-1413 (Formulation
)
/
Dow Number
Date
Author
Recipient
07508740750876*
590706
07508780750903*
590506
Dow Hoyle, HR Olson, KJ Oyen, F
Dow McCollister, DD Wolf, MA
Distributees
Colby, RW Dow Elshere, D Gay, HH Gray, HE Greene, LM Hammer, OH Hart, A Hymas, TA Jones, GD Kagy, JF K111an, DJ Luce, EN Lynn, GE McIntyre, HH Perkins, RP Scoles, G Stenger, VA Tisdale, WL Wright, N
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Gay, HH
Page 13 General Subject Matter of Dowanol Ester 245T) made for the Stull Chemical Company
M-1413 Formulation of K 7856 (Dowanol Ester 245T). Data sheet of properties, health hazards and precautions fo r safe handling of materials Results of range finding toxicolo gical tests on M-1447 and M-1443 Weed K ille r Formulations (Similar to Esteron 245 OS and Esteron Brush K ille r OS respectively)
Dow Number
Date
Author
Recipient
07509150750940*
590506
Dow McCollister, DD Wolf, MA
)\
j
Distributees
Gray, HE Greene, LM Hammer, OH Hart, A Hymas, TA Jones, GD Kagy, JF K1l1an, DJ Luce, EN Lynn, GE McIntyre, HH Perkins, RP Stenger, VA Tisdale, WL Vanvalkenburg, JW Wright, N
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Gay, HH Gray, HE Greene, LM Hammer, OH Hart, A Hymas, TA Jones, JD Kagy, JF K111an, DJ Luce, EN Lynn, GE
General Subject Matter
Page 14
Results of range finding toxicolo gical tests on M-1447 and M-1433
Weed K ille r Formulations (Similar to Esteron 245 OS and Esteron Brush K ille r OS respectively)
i
Dow Number
Date
Author
Recipient
07509510750952*
591209
Dow Wolf, MA
07509560750974*
590903
Dow
Olson, KJ Oyen, F
McIntyre, HH
CO
CCOD
00
Distributees
McIntyre, HH Perkins, RP Stenger, YA Tisdale, Wl Vanvalkenburg, JW Wright, N
Dow Wolf, MA
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Gay, HH Greene, LM Hammer, OH Hart, A Hynas, TA Jones, GD Kagy, JF K ilian , DJ Leasure, JK Luce, EN Lynn, GE McIntyre, HH Perkins, RP Scoles, G Stenger, YA Tisdale, WL Wright, N
General Subject Matter
Page 15
Toxicological information on Esteron 99 granules (M-1741) suitable for presentation to the USDA
Results of range finding toxicolo gical tests on Agricultural Chemical Formulation M-1511 con taining Dowanol 97B70 Ester 245T (K--7856)
)
>>
Dow Number
07509750750976*
Date 590811
07509770550996*
600216
Author
Dow HRH Olson, KJ Oyen, F
Dow Olson, K Oyen, F
Recipient
07509980751016*
600223
Dow Olson, KJ
Oyen, F
ZOD.
C03>
I
Distributees
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Gay, HH Greene, LM Hammer, OH Hart, A Hymas, TA Jones, GD Kagy, JF K111an, DJ Luce, EN Lynn, GE McIntyre, HH Perkins, RP Scoles, GW Stenger, VA Tisdale, WL Wright, N
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D
Page 16 General Subject Matter M-1511 Data sheet of properties, health hazards and precautions for safe handling of materials
Results of range finding toxicolo gical tests on Agricultural Chemical Formulation M-1683 (Esteron 245 Type)
* Results of range finding toxicolo gical tests on Agricultural Chemical Formulation M-1684 (Esteron Brush K ille r Type)
/
Dow Number
Date
Author
Recipient
07510560751058*
611120
Dow Olson, KJ
Oyen, F Plomer, ET Scoi es, GW
13970
)
}
Distributees
Gay, HH Greene, LM Hammer, OH Hart, A Hymas, TA Jones, GD Kagy, JF K11Ian, DJ Luce, EN Lynn, GE McIntyre, HH Perkins, RP Scoles, GW Stenger, VA Tisdale, WL Wright, N
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Falkensteln, W Gay, HH Greene, LM Hart, A Jones, GD Kagy, JF K lU a n , DJ Luce, EN Lynn, GE McIntyre, HH Perkins, P
General Subject Matter
Page 17
Results of range finding toxicolo gical tests on M-2115, an agricultural chemical formulation containing 245T and tr1ethyl amine
>
)
Dow Number
Date
Author
Recipient
0751059 *
611120
07510600751075*
611106
Dow Hoyle, HR
Olson, KJ Oyen, F Plomer, ET
13971
) )
Distributees
Scoles, GW Shrader, SA Tisdale, WL Wright, N
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Falkensteln, W Gay, HH Greene, LM Hart, A Jones, GD Kagy, JF K1l1an, DJ Luce, EN Lynn, GE McIntyre, HH Perkins, P Scoles, GW Shrader, SA Tisdale, WL Wright, N
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Falkensteln, W Gay, HH
General Subject Matter
Page 18
F irs t aid measures
M-2115 data sheet of properties, ' health hazards and precautions for safe handling of materials
Dow Number
Date
Author
Recipient
07510780751080*
620403
Dow Olson, KJ Oyen, F Vanvalkenburg, W
13972
) )
Distributees
Greene, LM Hart, A Jones, GD Kagy, JF K1l1an, DJ Luce, EN Lynn, GE McIntyre, HH Perkins, P Scoles, GW Shrader, SA Tisdale, WL Wright, N
Barrons, KC Boundy, RH Brown, R Colby, RW Dow Elshere, D Falkenstein, WJ Gay, HH Greene, LM Hart, A Jones, GD Kagy, JF K1l1an, DJ Luce, EN Lynn, GE McIntyre, HH Nash, HA Perkins, RP Shrader, SA
General Subject Matter
Page 19
Results of range finding toxicolo gical tests on M-2235, an emulsi z a b le formulation of 24D and 245T Dowanol Esters 1n kerosene
))
)
Dow Number
Date
Author
0751081 *
620323
Recipient
07510820751098*
620323
CKo* CO cNol
Dow Hoyle, HR 01 son, KJ Oyen,
Distributees
Yanvalkenburg, W Wilson, AW Wright, N
Barrons, KC Boundy, RH Brown, R Colby, RW Dow Elshere, D Falkenstein, WJ Gay, HH Greene, LM Hart, A Jones, GD Kagy, JF K1l1an, DJ Luce, EN Lynn, GE McIntyre, HI Nash, HA Perkins, RP Shrader, SA Yanvalkenburg, W Wilson, AW Wright, N
Barrons, KC Boundy, RH Brown, R Colby, RW Dow Elshere, D
General Subject Matter
Page 20
F ir s t aid measures
M-2235 data sheet of properties, health hazards, and precautions for safe handling of materials
Dow Number
Date
Author
Recipient
07510990751101*
0751102 *
07512090751210*
630809 620124 630225
Hoyle, HR Olson, KJ Oyen, F
Dow Wolf, MA
Dow Olson, KJ Oyen, F
Dow McIntyre, HH
) )
I
Distributees
Falkensteln, WJ Gay, HH Greene, LM Hart, A Jones, GD Kagy, JF K111an, DJ Luce, EN Lynn, GE McIntyre, HH Nash, HA Perkins, RP Shrader, SA Yanvalkenburg, W Wilson, AW Wright, N
General Subject Matter
Page 21
Verton T sales specification
Barrons, KC Boundy, RH
Brown, R Colby, RW Dow Elshere, D Falkensteln, WJ
Gay, HH Greene, LM
Suggested precautionary labeling for M-2235
Results of range finding toxicolo gical tests on agricultural cheml- v cal formulation M-2422 containing ' 91 percent Dowanol PIB Ester of 245T
.) > )
Dow Number
Date
Author
Recipient
0751211 *
630225
QCDo
'OT
))
I
}
Distributees
Hart, A Jones, GD Kagy, JF K ilia n , DJ Luce, EN Lynn, GE McIntyre, HH MulHson, WR Nash, HA Norton, TR Shrader, SA Wilson, AW Wright, N
Barrons, KC Boundy, RH Brown, R Colby, RW Dow Elshere, D Falkenstein, WJ Gay, HH Greene, LM Hart, A Jones, GD Kagy, JF K ilia n , DJ Luce, EN Lynn, GE McIntyre, HH Mullison, WR Nash, HA Norton, TR
General Subject Matter
Page 22
F irs t aid measures *
I )) )
Dow Number
Date
Author
Recipient
07512120751213*
630220
Dow Hoyle, HR 01 son, KJ Oyen,
07512140751236*
630225
QQDJ
'" '3
I)
)
)
D1strlbutees
Shrader, SA Wilson, AW Wright, N
Barrons, KC Boundy, RH Brown, R Colby, RW Dow Elshere, D Falkenstein, WJ Gay, HH Greene, LM Hart, A Jones, GD Kagy, JF K ilia n , DJ Luce, EN Lynn, GE McIntyre, HH Mullison, WR Nash, HA Norton, TR Shrader, SA Wilson, AW Wright, N
Barrons, KC Boundy, RH Brown, R Colby, RW Dow Elshere, D
General Subject Matter
Page 23
M-2422 data sheet of properties, health hazards and precautions for safe handling of materials
Toxicological properties of Formulation M-2422
*
}
Dow Number
Date
Author
Recipient
07522640752265*
670328
0752266 *
07523600752361*
07523850752386*
661220 670410 690415
Dow Hoyle, HR
M cCollister, DD Olson, KJ
Buerge, TE Dow
Dow Lynn, 6E
Dow Norris, JM Torkel son, TR
CCOQ -si.
) )
Distributees
Falkensteln, WJ Gay, HH Greene, LM Hart, A Jones, GD Kagy, JF K111an, DJ Luce, EN Lynn, GE McIntyre, HH MulHson, WR Nash, HA Norton, TR Shrader, SA Wilson, AW Wright, N
Axe, FD Barton, J Beauchamp, RR B la ir, EH Burgert, BE
)
General Subject Matter
Page 24
M-3060 data sheet of properties, health hazards and precautions for safe handling of materials
M-3060 request for screening or application testing
M-3060, Safety Data and Formulation
M-3401 Brush K1ller-A Tordon Acid Formulation
)
Dow Number
Date
Author
Recipient
07523880752389*
690320
07523900752395*
690417
07525500752552*
700130
eg
-s?
CD
Dow Hoyle, HR Norris, JM Torkelson, TR
Dow N orris, JM
Dow Gowell, JH Loucks, MF Lynn, GE Naegele, RE
) )
Distributees
Dow Edwards, H Elshere, D Gordon, HL Holder, BB Johnson, JE Kagy, JF K11Ian, DJ Klmmel, CE Lloyd, BH MacCutcheon, SM M cCollister, DD McIntyre, HH Morse, D P1tman-Moore Robinson, VB Schwartz, AJ Wright, N
General Subject Matter
Page 25
M-3402 Brush K ille r data sheet of properties, health hazards and precautions for safe handling of materials
Toxicological properties of M-3401
Brush KH ler-A Tordon acid for- *
mulatlon
i
Tordon 225 herbicide release to sales
hr
)
Dow Number
Date
07525530752554*
690429
07624930762496*
500829
0762497 * 0762498 *
000000 490309
0762499 *
^4 KCCSSO
to
490412
Author
Newport, JJ Ridner, JM Seymour, KG Stein, JS Williams, CS Williams, RW Wolf, MA
Dow Hoyle, HR Norris, JM
Recipient
Dow Rowe, VK Spencer, HC
Allen, WW Barrons, KC Britton, JW
Dosser, RC Dow
Dutton, WC
Irish , DD Kagy, JF Lynn, GE
Dow Irish , DD M cCollister, DD Rowe, VK White, L
Dow Wyse, H
)
;
Distributees
General Subject Matter
Page 26
Tordon 225 mixture herbicide data sheet of properties, health hazards and precautions for safe handling, of materials
Results of range finding toxicolo gical tests on Esteron 245T for mulations
Summary of toxicological Infor mation on 24D & 245T formulations
Esteron 245T (New formulation) (Request for biological test)
' '
K7716-1 Esteron 245T (New formulation) (Acute oral toxicity)
)
Dow Number 0762500 *
Date 490321
07625010762504*
0762505 *
490000 490517
0762506 *
490225
0762507 *
490414
0762508 *
490321
07625090762512*
0762513 *
490000 490517
07666980766699*
690415
Author
Dow Wyse, H
Dow Wyse, H
Dow Wyse, H
Recipient
Dow HAS RSH Irish Rowe, VK White, L
Dow Wyse, H
Dow Wyse, H
Dow Wyse, H
Dow Wyse, H
Beauchamp, RR Dow Norris, JM
13980
)I
I
Distributees
Page 27
General Subject Matter
Esteron 245T (New formulation)
K7716-1 Esteron 245T (New formulation) (Skin Irritatio n )
K7716-1 Esteron 245T (New formulation) (Single absorption exposure record)
Esteron 245T formulation (Request for biological test)
Axe, FD Barron, J Beauchamp, RR
K7716-2 Esteron 245T formulation (acute oral toxicity)
Esteron 245T formulation
K7716-2 Esteron 245T formulation-
(Skin irrita tio n )
v.
K7716-2 Esteron 245T formulation (Single absorption exposure record)
M-3401 Brush K1ller-A Tordon Acid Formulation
)!\ )
Dow Number
Date
Author Torkel son, TR
Recipient
07667000766701*
690320
07667020766708*
690417
0766709 *
681008
QCCDOo
^4
Dow Hoyle, JR Norris, JM Torkel son, TR
Dow Norris, JM
Beauchamp, RR Byrd, BC Dow Dow McCol H s t e r , DD Hoerger, FD
M cCollister, DD
) )
\
Pistrlbutees
B la ir, EH Burgert, BE Dow Edwards, H Elshere, D Gordon, HL Holder, BB Johnson, JE Kagy, JF K ilia n , DJ Kimmel, CE Lloyd, BH MacCutcheon, SM M cCollister, DD McIntyre, HH Morse, D Robinson, VB Schwarz, AJ Wright,. N
General Subject Matter
Page 28
M-3401 Brush K ille r (Data sheet of properties, health hazards and precautions for safe handling of materials)
Toxicological properties of M-3401 Brush K ille r , a Tordon acid formulation
Proposed name, Tordon 124V Brush K ille r (M3401) (Request for screening or application testing)
Dow Number 0766710 *
Date 681008
07667110766726*
680000
07667270766729*
07667300766737*
690310 680000
07667380766740*
07667410766744*
07667450766746*
07667470766750*
07667510766765*
681000 681104 690128 690000 690123
0766766 *
QOCCO>
to
690123
Author Dow
Recipient
Dow Litchfield, N Norris, JM
Dow Norris, JM
Dow King, CD Litchfield, N Sparschu, GL Trice, V
Dow Dunn, FL
Dow Dunn, FL
Dow Dunn, FL
Dow Litchfield, N
Dow Norris, JM
Dow
Distributees
Page 29
General Subject Matter
Toxolcology work sheet (Tordon 124V Brush K ille r)
Tordon 124V Brush K ille r (Acute oral toxicity)
M-3401 Brush K ille r , oral dosage to male rats
Tordon 124V Brush K ille r (Request for pathology)
Tordon 124V Brush K ille r (Eye con tact test)
Tordon 124V Brush K ille r (Skin contact, Irritation)
M-3401 Tordon 124V Sample 2, (Skin
contact, Irritation)
*
Tordon (Skin contact absorption)
Toxicological properties of Tordon 124V Brush K ille r made with CA Tordon acid
Tordon 124V Brush K ille r (Toxicology work sheet)-
Dow Number 0766767 *
Date 681008
07667680766769*
000000
Author
Recipient
Beauchamp, RR
Dow McCollister, DD
Dow
07667700766800*
680000
07668010766821*
680000
07668220766823*
690107
07668240766847*
690113
fazr.
Go CCOD
CO
Dow Dunn, FL Litchfield, N
Conran, PB Dow King, CD Litchfield, N Sparschu, GL Trice, V
Beauchamp, RR Dow Leong, BKJ Trice, VR
Beauchamp, RR Conran, PB Dow Leong, BKJ Sparschu, GL T rice, VR
)J
Distributees
Page 30
General Subject Matter
Proposed name Tordon 124V Brush K ille r (Request for screening or application testing)
M3401 Brush K ille r (Data sheet of properties, health hazards and precautions for safe handling of. materials)
Tordon 124V Brush K ille r , male rat testing
Tordon 124V Brush K ille r (Request for pathology)
Summary report on the effect of acute Inhalation of the vo latile components of California Tordon Acid and Texas Tordon Acid (Biochemical Res Lab Sample 1)
Summary pathology report on the effect of acute Inhalation of the v o la tile components of California Tordon Acid and Texas Acid (Blochem Res Lab Pathology Report Sample)
Dow Number
07670180767019*
Date 560412
07670200767021*
610525
07670220767023*
07670240767025*
07670260767027*
790216 720329 580613
07670280767029*
610525
0767030 * 0767031 * 0767032 *
610531 000000 700721
Author Dow
Recipient
Dow Hoyle, HR Olson, KJ Oyen, F
Dow Fishbeck, WA Keeler, P
Dow
Dow McCollister, DD Wolf, MA
Dow Olson, KJ Oyen, F
Dow
Dow
Dow
QO oo
)
Distributees
Page 31
General Subject Matter
Esteron Brush K ille r OS M-726 (T2.30-71-1), safety data sheet with formulation
Esteron 99 data sheet of proper tie s , health hazards and pre cautions for safe handling of materials
Esteron 99 medical Information
Esteron 99 material safety data sheet
Esteron 99 data sheet of proper tie s , health hazards and pre cautions for safe handling of materials
Esteron 99 data sheet of proper tie s , health hazards and pre cautions for safe handling of materials
Esteron 99 (Replacement formulation)
Esteron 99 medical Information symptomatology and treatment
Esteron 99 toxicology, anticipated human response
}
)
Dow Number 0767033-
0767034* 0767054-
0767055*
07670560767057*
0767058 *
07670590767060*
0767061 *
0767062 *
07670630767064*
0767065 *
cCCOO
Date 720329 570514
580514
000000 710900 580716 610112 580425
580717
Author Dow
Recipient
Dow Hoyle, HR M cCollister, DD Wolf, MA
Dow Hoyle, HR M cCollister, DD Wolf, MA
Dow Hoyle, HR Wolf, MA
Dow
Dow Wolf, MA
Dow Wolf, MA
Dow McIntyre, HH
Dow McIntyre, HH
Dow Hoyle, HR M cCollister, DD Olson, KJ
Dow Hoyle, HR Olson, KJ
)
)
Distributees
Page 32
General Subject Matter
Esteron 99 material safety data sheet
M-1086 data sheet of properties, health hazards and precautions for safe handling of materials
Veon brush k ille r (M-1086) data sheet of properties, health hazards and precautions for safe handling of materials
M-1086 (A herblcldal formulation T2.3098), safety data sheet
Veon brush k ille r
Suggested precautionary labeling for M-1094
Suggested precautionary labeling for M-1094
4
M-1094 weed k ille r formulation data sheet of properties, health hazards and precautions for safe handling of materials
M-1094 containing 245T Ester T2, 30-112-1, safety data sheet
Dow Number 0767066 *
07670670767068*
Date 570730
571120
07670690767070*
571028
0767071 *
571206
0767072 *
571206
0767073 *
07670730767074*
610112 610311
0767075 *
07670920767098*
610400 531029
Author
Recipient
Dow Wolf, MA
Coulter, LL Dow
Dow Hoyle, HR McCollister, DD
Olson, KJ
Dow Hoyle, HR McCollister, DD Olson, KJ
Dow Hoyle, HR Olson, KJ
Dow Hoyle, HR Olson, KJ
Dow Wolf, MA
Dow McIntyre, HH
Dow Hoyle, HR
Olson, KJ Oyen, F
Dow
Adams, EM
)
>
Distributees
Allen, WW
Page 33
General Subject Matter
Inverton, a le tte r showing concern for hazards
Inverton M-1116 data sheet of pro perties, health hazards and pre cautions for safe handling of material s
M-1116 dilution Cl-14-100 data sheet of properties, health hazards and precautions for safe handling of materials
Inverton weed k ille r (M-1116) T2.30-101-1, safety data sheet
M-1116 dilution Inverton for mulation
Suggested precautionary labeling for M-1123
M-1123 data sheet of properties, ;
health hazards and precautions for
safe handling of materials
^
M-1123, safety data sheet
Results of range finding toxlcolo-
't
Dow Number
Date
Author
Dow Eslunn, E Maxey, JS Oyen, F
Recipient
0767099-
530325
0767119*
0767153-
570806
0767160*
Dow HCS Rowe, VK Wolf, MA
Dow McCollister, DD Wolf, MA
b**
COGo
CO
"sj
)}
/
)
Distributees
Allinson, RL Alqulst, FN Barrons, KC Beshgetoor, AW Boundy, RH Britton, EC Davidson, JH Dow Dutton, WC Gay, HH Greene, LM Kagy, JF Luce, EN Lynn, GE MacCutcheon, SM Prescott, RF Sunderland, WW White, LC Wright, P'
AlHnson, RL Athay, RM Beshgetoor, AW Boundy, RF Colby, RW Dow Elshere Gay, HH
Page 34
General Subject Matter
gical tests on Dow Brush K ille r 50-50
Toxicity of Dow Brush K ille r 50-50 (T2.30-28-1 )
Results of range finding toxicological tests on M-1085 (A 245T
triethyl amine liq u id formulation T2.30-97-1)
it '
Dow Number
Date
Author
Recipient
07671540767155*
571005
0767161 *
570228
0767162 *
570301
07671630767164*
570402
07671650767166*
570415
Dow Hoyle, HR McCollister Wolf, MA
Dow
Dow
Babcock, D Dow Wolf, MA
Dow .
Barrons, KC Dow
))
Distributees
Greene, LM Hart, A Jones, GD Kagy, JF K111an, DJ Luceen Lynn, GE McIntyre, HH Mussel 1, DR Perkins, RP Scoles, GW Tisdale, WL Wright, N
General Subject Matter
Page 35
M-1085 (A 245T alkyl amine formulation) data sheet of pro perties, health hazards and pre cautions for safe handling of materials
Sample 1, M-1085 (T2.30-97-1), eye and skin contact
M-1085 request for applications testing (2.30-97-1)
Sample 1 (2.30-97-1) (eye contact -i test)
Sample 1 M-1085 skin contact I r r i tation T2.30-97-1
>)
J
Dow Number
07671840767191*
Date 570806
Author
Recipient
Dow McColUster, DD Wolf, MA
07671850767186*
570511
0767192 * 0767193 *
570228 570227
CCOO ce
co
Dow Hoyle, HR McColUster Wolf, MA
Dow Wolf, MA
Dow Scoi es, G
Barrons, KC Dow
)
)
Distributees
A lliso n , RW Athay, RM Barrons, KC Beshgetoor, AW Boundy, RH Colby, RW Dow Elshere, D Gay, HH Greene, LM Hart, A Jones, GD Kagy, JF K111an, DJ Luce, EN Lynn, GE McIntyre, HH Perkins, RP Russel, DR Scoles, G Tisdale, WL Wright, N
Page 36
General Subject Matter
Results of range finding toxicolo gical tests on M-1086 (A 245T and 24D alkyl amine formulation)
M-1086 (Data sheet of properties,
health hazards and precautions for :
safe handling of materials)
Sample 1, M-1086 (Toxicology work sheet)
M-1086 (2.30-96-1) (Request for applications testing)
])
I
>
Dow Number
07671940767195*
07671960767197*
07672130767222*
Date 570326
570228 580521
Author
Dow Stagerstron, E
Dow
Recipient
Dow M cCollister, DD Olson, K
07672160767217*
580425
CCOO oC o
Dow Hoyle, HR McColHster, DD
Olson, KJ
)
D1strlbutees
Allinson, RL Athay, RM Beshgetoor, AW Boundy, RH Colby, RW Dow Elshere, D Gay, HH Greene, LM Hammer, OH Hart, A Jones, GD Kagy, OF K ilia n , DJ Luce, EN McIntyre, HH Perkins, RP Scoles, GW Tisdale, WL Vanvalkenburg, W Wright, N
Page 37 General Subject Matter Eye contact test M-1086, T2.30-96-1 M-1086 (Skin contact Irritatio n ) (T2.30-96-1) Results of range finding toxicolo gical tests on weed k ille r for mulation M-1094 containing a 245T Ester (T2.30-112-1)
*
k r
M-1094 Weed K ille r formulation (Data sheet of properties, health hazards, and precautions for safe handling o f materials)
J/ t
Dow Number 0767223 * 0767224 * 0767225 *
Date 580225 000000 580218
Author
Dow
Dow Scoles, G
Coulter, LL Dow
Recipient
Dow Rowe, VK
0767226 *
580225
07672270767228*
07672290767230*
530311 580525
0767231 *
580402
Dow NCG
Dow NCG
Dow NCG
Coulter, LL Dow
Dow Rowe, VK
07672430767251*
571220
Dow McCollister, DD
Olson, KJ
rt j j cb
)
)
Distributees
Dow Fletcher, FW Scoles, GW Vanvalkenburg, W
Dow Fletcher, FW Scoles, GW Vanvalkenburg, JW AlUnson, RL Beshgetoor, AW Boundy, RH Colby, RW Coulter, LL Dow
Page 38
General Subject Matter
Sample 1 Weed K ille r formulation (M-1094) (Toxicology work sheet)
245T (Request for screening or application testing)
Formulation M-1094, contemplated sales program
Sample 1 Weed K ille r formulation (M-1094) (T2,30-112-1) (acute oral toxicity)
Sample 1 Weed K ille r formulation (M-1094) (eye contact test)
Sample 1, weed k ille r formulation (M-1094) (T2.30-112-1) (skin con tact Irritation)
M-1094, w ill remain 1n development during 580000
*
Results of range finding toxicolo gical tests on Inverton (brush k ille r ) . (T2.30-101-1)
))
)
)
Dow Number
Date
Author
Recipient
07672450767246*
571120
0767252 * 0767253 *
570520
000000
0767254 *
570520
>-4 0767255CO 0767256* CQ CD
ro
570520
Dow Hoyle, HR McCollister, DD Olson, KJ
Dow
Dow Scoles, G
Dow
Babcock, D Dow
) )
D1strlbutees
Elshere, D Gay, HH Gray, HE Greene, LM Hart, A Hymas, TA Jones, GD : Kagy, JF K1Han, DJ Luce, EN Lynn, GE McIntyre, HH Mussel 1, DR Perkins, RP Scoles, GW Tisdale, WL Wright, N
))
General Subject Matter
Page 39
Urt
Inverton M-1116 (Data sheet of properties, health hazards and precautions for safe handling of materials)
Sample 1 M-1116 (T2.30-101-1) (Toxicology work sheet)
4
y
M-1116 (Request for applications testing) (2.30-101-1)
Sample 1 M 1116 (Acute oral toxicity) (T2.30-101-1)
Sample 1 M-1116 (Eye contact test) (T2.30-101-1)
)I
)
Dow Number
07672570767258*
07672590767260*
0767261 *
Date 570624 570730
580221
0767262 *
580408
07672630767267*
610316
Author
Babcock, D Dow
Dow Wolf, MA
Dow
Dow Wolf, MA
Dow Olson, KJ Oyen, K Thompson, E Vanvalkenburg
Recipient
Coulter, LL Dow Dow Olson, KJ Dow McIntyre, HH
CCOO
CCoO
)
;
D1strlbutees
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Falkensteln, WJ Gay, HH Greene, LM Hart Jones, GD Kagy, JF K11ian, DJ Luce, EN Lynn, GE McIntyre, HH Perkins, RP Shrader, SA Tisdale, WL Vanvalkenburg, W Wright, N
Page 40
General Subject Matter
Sample 1 M-1116 (Skin contact irrita tio n ) (T2.30-101-1)
Inverton, a le tte r showing concern for hazards
Request for report
Suggested precautionary labelling for Inverton (M-1116)
Results of range finding toxicolo gical tests on M-1123 (T2.30-201-1)
Dow Number
07672680767269*
Date 610311
0767270 * 0767271 * 0767272 *
601228 601229 601223
0767273 *
610106
0767274 *
601228
07672750767276*
07672770767280*
07672810767282*
07672880767300*
610110 601228 610120 610601
CCCDDO
i4^
Author
Dow Hoyle, HR Olson, KJ Oyen, F
Dow
Recipient
Dow
Dow Dow Vanvalkenburg, W Olson, KJ
Dow Wolf, MA
Dow
Dow Ri tty , PM
Dow Thompson, E
Dow Thompson, E
Dow Thompson, E
Dow White, LC, Jr.
Distributees
Dow Johnson, JE Ri tty , PM
Barrons, KC Boundy, RH Colby, RW
Page 41
General Subject Matter
M-1123 (Data sheet of properties, health hazards and precautions for safe handling of materials)
M-1123 (Toxicology work sheet) (T2.30-201-1 )
M-1123 (request for screening or application testing)
M-1123, Formulation, use, release to sale plans
Formulation for M-1094, no data available on to x icity for M-1123
Sample 1 M-1123 (Acute oral toxicity) (T2.30-201-1 )
Sample 1 M-1123 (Eye contact test) (T2.30-201-1 )
Sample 1 M-1123 (Skin contact 1r r lta tlo n ) (T2.30-201-1)
Sample 1 M-1123 (Skin contact absorption) (T2.30-201-1)
Results of range finding toxlcolo?1cal tests on Esteron 245-OS
replacement for present for-
>
Dow Nunber
Date
Author
Recipient
07673010767314*
600125
Dow Wolf, MA
1.39 S5
)I )
Distributees
Dow Elshere, D Falkenstein, WJ Gay, HH Greene, LM Hart, A Jones, GD Kagy, JF K111an, DJ Luce, EN Lynn, GE McIntyre, HH Oyen, F Perkins, RP Shrader, SA Tisdale, WL White, LC, J r. Wright, N
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Gay, HH Greene, LM Hammer, OH Hart, A Hymas, TA Jones, GD Kagy, JF K111an, DJ Luce, EN
Page 4< General Subject Matter mulatlon M-1257) (BC T2.30-167-2)
Results of range finding toxicolo gical tests on Esteron 245 OS(M.1257) (BC T2.30-167-1)
<r
Dow Number
Date
Author
Recipient
0767309 *
591102
Dow Dow Vanvalkenburg,JW Wolf, MA
CCiOp '
0767315 *
591028
Dow R1tty, PM
Dow Wolf, MA
Distributees
Lynn, 6E McIntyre, HH Oyen, F Perkins, RP Stenger, VA Tisdale, WL Wright, N
Barrons, KC Boundy, RH Colby, RW Coulter, LL Dow Elshere, D Gay, HH Greene, LM Hammer, OH Hart, A Heath, SB Hymas, TA Jones, GD Kagy, JF K ilia n , DJ Luce, EN Lynn, GE McIntyre, HH Oyen, F Perkins, RP Stenger, VA Tisdale, WL Wright, N
Barrons, KC Boundy, RH
General Subject Matter
Page 43
Esteron 245 OS (M-1257), For
mulation plans for toxicological evaluat1on
Vr
Need toxicology information sheets on Esteron Brush K ille r
Dow Number
Date
Author
Recipient
07673210767342*
571122
Dow Olson, KJ
)I
)
)
Distributees
Colby, RW Coulter, LL Dow Elshere, D Gay, HH Greene, LM Hammer, OH Hart, A Heath, SB Hymas, TA Jones, GD Kagy, JF K1l1an, DJ Luce, EN Lynn, GE McIntyre, HH Oyen, F Perkins, RP Stenger, VA Tisdale, WL Wright, N
AlUnson, RL Athay, RM Beshgetoor, AW Boundy, RH Colby, RW Dosser, RC Dow Elshere, D Gay, HH Greene, LM Hart, A
General Subject Matter O.S.
Page 4
Results of range finding toxicolo
gical tests on Brush K ille r X, Weec K ille r X and Brush K ille r TX {T2.30-76-1 T2.30-77-1
T 2 . 30-78-1)
) )
Dow Number
Date
Author
Recipient
07673660767385*
590423
Dow Wolf, MA
Co
CO
CCDD
)) )
.1
Distributees
Hymas, TA Jones, GD K111an, DJ Luce, EN Martin, D M cColllster, DD McIntyre, HH Mussel 1, DR Perkins, RP Tisdale, WL White, LC Wright, N
Athay, RM Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Gay, HH Greene, LM Hammer, OH Hart, A Hymas, TA Jones, GD Kagy, JF K1l1an, DJ Luce, EN Lynn, GE M cColllster, DD McIntyre, HH Perkins, RP Stenger, VA
General Subject Matter
Page 45
Results of range finding toxicolo gical tests on Forron brush k ille r (M-1368) (T2.30-123-1)
V
) J)
) r
Dow Number
Date
Author
Recipient
07674170767418*
590506
Dow M cCollister, DD Wolf, MA
07674190767421*
590202
07674220767930*
590202
Dow Hoyle, HR M cCollister, DD Wolf, MA
Dow Hoyle, HR M cCollister, DD Wolf, MA
CCCDDO
CO
I)
)
I
I
Distributees
Tisdale, WL Vanvalkenburg, W Wright, N
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Gay, HH Gray, HE Greene, LM Hammer, OH Hart, A Hymas, TA Jones, GD Kagy, JF K1l1an, DJ Luce, EN Lynn, GE McIntyre, HH
General Subject Matter
Page 46
Results of range finding toxicolo gical tests on M-1447 and M-1433 weed k ille r formulations (Similar to Esteron 245 OS and Esteron Brush K ille r respectively)
A concentrate formulation of 245T Dowanol 97B70 Ester data sheet of properties, health hazards and precautions for safe handling of material s
A concentrate formulation of 24D and 245T Dowanol 97B70. Esters data sheet of properties, health hazards and precautions for safe handling of materials
; > >) )
Dow Number
Date
Author
Recipient
0767431 * 0767432 *
590127 581120
Dow
Dow Wade, J
0767433 *
581121
07674340767439*
07674400767441*
581120 590506
Dow Dow Vanvalkenburg,JW Olson, KJ
Dow
Dow M cCollister, DD Wolf, MA
07674420767444*
590202
Dow Hoyle, HR M cCollister, DD Wolf, MA
14000
)
Distributees Perkins, RP Stenger, VA Tisdale, HH Vanvalkenburg, W Wright, N
Coulter, LL Dow Heath, SB
General Subject Matter
Page 47
M-1433 Toxicology work sheet
A concentrate brush k ille r for mulation of 31b. 24D and 31b. 245T acid equlv per gal. based on Dowanol 97B70 Esters. Request for screening or application testing
M-1433 and M-1447, formulations
M-1433 eye contact test
Results of range finding toxicolo gical tests on M-1447 and M-1433 weed k ille r formulations (Similar to Esteron 245 OS and Esteron Brush K ille r OS respectively)
M-1447 A concentrate formulation of 245T Dowanol 97B70 esters. Data sheet of properties, health hazards and precautions for safe handling of materials
Dow Number
07674450767453*
Date 590202
Author
Recipient
Dow Hoyle, HR M cCollister, DD Wolf, MA
0767454 *
07674550767456*
590127 581120
07674570767462*
07674630767464*
581120 590202
Dow
Dow Vanvalkenburg, JW Dow
Dow Hoyle, HR
I
)
I
>
Distributees
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Gay, HH Gray, HE Greene, LM Hammer, OH Hart, A Hymas, TA Jones, GD Kagy, JF K11ian, DJ Luce, EN Lynn, GE McIntyre, HH Perkins, RP Stenger, VA Tisdale, WL Vanvalkenburg, JW Wright, N
Page 48 General Subject Matter M-1433 A concentrate formulation of 24D and 245T Dowanol 97B70 esters. Data sheet of properties, health hazards and precautions for safe handling of materials
M-1447 toxicology work sheet
M-1447 request for screening or application testing
M-1447 acute oral toxicity
M-1433 A concentrate formulation of 24D and 245T Dowanol 97B70
)
Dow Number
Date
07674650767466*
07674780767479*
700709 590713
07674800767485*
590414
Author
Recipient
McColllster, DD Wolf, MA
Dow
Dow McColllster, DD Wolf, MA
Dow McColllster, DD Peterson, JE Wolf, MA
rOOo
)) )
)
Distributees
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Gay, HH Greene, LM Hammer,. OH Hart, A Hymas, TA Jones, GS Kagy, JF K111an, DJ Luce, EN Lynn, GE McIntyre, HH Perkins, RP Stenger, VA Tisdale, WL Vanvalkenburg, W Wright, N
Page 49 General Subject Matter esters. Data sheet of properties, health hazards and precautions for safe handling of materials Dowanol 97 B-70 medical Infor mation Results of range finding toxicolo gical tests on Forron 235T
Forron 245 M-1456 data sheet of properties, health hazards and precautions for safe handling of materials
V>
)
)
Dow Number 0767486 *
0767487 *
Date 590319
590127
Author Dow
Dow
Recipient
0767488 *
590113
07674890767493*
0767494 *
07674950767497*
590127 000000 590610
0767498 *
590722
07674990767504*
590702
O .oCO
Dow Dow Vanvalkenburg,JW Olson, RJ
Dow
Dow Wolf, MA
Dow M cCollister, DD Peterson, JE Wolf, MA
Dow Olson, K Oyen, F
Dow Hoyle, HR Olson, KJ Oyen, F
)
Distributees
Coulter, LL Dow Heath, SB
Athay, RM Barrons, KC Boundy, RH Colby, RW Dow Elshere, D
Page 50
General Subject Matter
M-1456 (Forron 245T) toxicology work sheet
M-1456 (Contains K-7756) (Forron 245) Request for screening of application testing
Formulation M-1456
M-1456 acute oral toxicity
Suggested precautionary labeling for Forron 245
Forron 245 (M-1456) Data sheet of properties, health hazards and precautions for safe handling of materials
Results of range finding tox1colo-k glcal tests on M-1459. Formulation, of K-7797 and K-7856
M-1459 formulation of K-7797 and K-7856
I)
)
Dow Number
Date
Author
Recipient
0767505 * 0767506 *
590618 590216
Dow Dow
07676350767637*
590901
Dow Olson, K Oyen, F
Scoi es, GE
^*4 OO
))
Distributees
Gay, HH Gray, HE Greene, LM Hammer, OH Hart, A Hymas, T Jones, GD K111an, DJ Lynn, GE Martin, D McIntyre, HH Perkins, RP Scoles, GE Stenger, VA Tisdale, WL Wright, N
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Gay, HH Greene, LM Hammer, OH Hart, A Hymas, TA
General Subject Matter
Page 51
M-1459 Toxicology work sheet
M-1459 formulation of K-7797 and request for screening or applica tion testing
Results of range finding toxicolo gical tests on M-1586 (Formulation containing Dowanol 97B70 Esters of 24D and 245T)(t2.30-156-1)
}
Dow Number
Date
Author
Recipient
07676380767639*
590811
0767640 0767641
590729 590611
Dow Hoyle, HR Olson, KJ Oyen, F
Oow KO
Oow Scoles, G
0767642 *
590610
Dow Scoles, GW
Dow Olson, KJ
oO Of
Distributees
Jones, GD Kagy, JF Kilian, DJ Leasure, JK Luce, EN Lynn, GE McIntyre, HH Perkins, RP Scoles, GE Stenger, VA Tisdale, WL Wright, N
Coulter, LL Dow Scoles, G
Coulter, LL Dow Dosser, RC Heath, SB Maddox, JF White, LC
General Subject Matter
M-1586 (Data sheet of properties, health hazards and precautions for safe handling of materials) M-1586 (Toxicology work sheet) (T2.30-156-1 ) Formulation containing the Dowanol 97B70 Esters of 24D and 245T (M-1586) (Request for screening or application testing) Improved Esteron formulation
))
) )
I
Dow Number 0767643 *
Date 590710
07676440767646*
07676470767649*
07676500767652*
590721 590727 590811
07677670767780*
600331
Author
Dow Greenhoe, NC KO
Dow Greenhoe, NC KO
Dow Greenhoe, NC KO
Dow Hoyle, HR Olson, KJ Oyen, F
Dow Olson, KJ Scoles, G
Recipient
))
D1strlbutees
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Gay, HH Greene, LM Hammer, OH Hart, A Hymas, TA Jones, GD Kagy, JF K111an, DJ Luce, EN Lynn, GE
Page 53
General Subject Matter
M-1586 (Acute oral toxicity) (T2.30-156-1)
M-1586 (Eye contact test) (T2.30-156-1)
M-1586 (Skin contact Irritation) (T2.30-156-1)
M-1586 (Data sheet of properties, health hazards and precautions for safe handling of materials)
Results of range finding toxicolo gical tests on agricultural chemi cal formulation M-1639 (Veon brush k ille r type)
>) I )
Dow Number
Date
Author
Recipient
07677920767793*
600128
0767794 * 0767824 *
600313 600216
Dow Hoyle, HR Olson, KJ Oyen, F
Dow
Dow Olson, KJ Oyen, F
CCDD !I
)
!
Distributees
McIntyre, HH Oyen, F Perkins, RP Scoles, G Stenger, VA Tisdale, WL Wright, N
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Gay, HH Greene, LM Hammer, OH Hart, A Hymas, TA Jones, GD Kagy, JF K1l1an, DJ Luce, EN Lynn, GE McIntyre, HH Perkins, RP
)
General Subject Matter
Page 54
M-1639 (Veon brush k ille r type) (Data sheet of properties, health hazards and precautions for safe handling of materials)
M-1639 (Veon brush k ille r type), Safety data sheet
Results of range finding toxicolo gical tests on agricultural chemi cal formulation M-1683 (Esteron 245 Type)
))I I i
Dow Number
Date
Author
R e d pi ent
07678250767828*
600223
Dow Olson, KJ
07678290767830*
600126
07678310767841*
600000
0767851M 0767852*
O0OO
600126
Dow Hoyle, HR Olson, KJ Oyen, F
Dow E0 NS O'Connor Scoles, GW Torkelson, TR
Dow Hoyle, HR Olson, KJ Oyen, F
)) )
)
Distributees
Scoles, G Stenger, VA Tisdale, WL Wright, N
General Subject Matter
Page 55
Corrections in biochemical research laboratory reports (T2.30-177-1) Results of range finding toxicological tests on agricultural chemical formulation M-1683 (Esteron 245 Type), Results of range finding
toxicological tests on Bis Acetonltrllo Decaborane (Band) (T23.14-94-2); Results of range
finding toxicological tests on Alpha Phenoxy Propionic Acid
M-1683 (Esteron 245T) (Data sheet of properties, health hazards and precautions for safe handling of materials)
Toxicology work sheet, acute oral to x icity , eye contact test, skin contact Irrita tio n , single vapor exposure record (M-1683)
' "
M-1683 (Esteron 245T) (Data sheet of properties, health hazards and precautions for safe handling of
materials)
) )
Dow Number 0767853 * 0767854 * 0767872 *
Date 600212 551108 600406
07678730767875*
600215
07679880767990*
611031
07679940767997*
611106
07680100768025*
611117
Author
Dow
Dow
Dow Wolf, MA
Dow 01son, KJ Oyen, F
Dow 01son, KJ Oyen, F
Dow Hoyle, HR Oyen, F Plomer, ET
Dow 01son, KJ Plomer, ET
Recipient
Dow McIntyre, HH
1^4
o
CO
)I )
I
D1strlbutees
Dow Sales Wolf, MA
Dow Hoyle, HR
Dow Hoyle, HR
Dow Hoyle, HR
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Falkensteln, W Gay, HH Greene, LM Hart, A Jones, GD
' Page 56
General Subject Matter
AG chem formulation M-1683
Esteron 245T, safety data sheet
Suggested precautionary labeling for M-1684
M-1684 (Esteron Brush K ille r type) Data sheet of properties, health hazards and precautions for safe handling of materials
M-2016 data sheet of properties, health hazards and precautions for safe handling of materials
M-2115 data sheet of properties, health hazards and precautions for safe handling of materials
Results of range finding toxicological tests on M-2115, an agricultural chemical formulation containing 245T acid and tr1ethyl amine
)
Dow Number
Date
Author
Recipient
07681040768143*
631129
Dow Lynn, GE Olson, KJ
^4 OMo
) )
\
Distributees
Kagy, JF K111an, DJ Luce, EN Lynn, 6E McIntyre, HH Oyen, F Perkins, RP Scoles, GW Shrader, Sa Tisdale, WL Wright, N
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Epstein, J Falkensteln, WJ Gordon, HL Greene, LM Hake, CL Hart, A Jones, GD Kagy, JF K111an, DJ Koerker, FW Luce, EN Lynn, GE McIntyre, HH MulHson, WR Norton, TR Oyen, F
General Subject Matter
Page 57
Results of range finding toxicolo gical tests on Verton T herbicide (M-2137) a formulation containing Dowanol Ester of 245T
V
;
Dow Number
Date
Author
Recipient
07682970768299*
630108
07683000768301*
0768302 *
710400 630507
07683030768304*
720328
07683050768306*
780401
07686800768699*
660526
Dow Hoyle, HR Olson, KJ Oyen, F
Dow
Dow
Dow
Dow Stevenson, GT
) )
Distributees
Shrader, SA Wilson, AW Wright, N
General Subject Matter
Page 58
M-2422 (Data sheet of proportions for safe handling of materials)
Esteron 245 concentrate
Esteron 245 concentrate (Sales specification)
Esteron 245 concentrate brush and weed k ille r (Material safety data sheet)
Esteron 245 concentrate brush and weed k ille r (Material safety data sheet)
Dow A summary of acute oral toxicity
Haagsma, TA
LD50 studies 1n poultry from
BLS TOX-37 thru TOX-66 Inclusive
GTS (Report GH-A 186)
KJO
Prod. Plan Target Team
Mgr.
Robinson, VB
RJS
RMS
RYJ
^
) )
Dow Number
07689840769027*
Date 660510
Author
Dow Lynn, GE Olson, KJ
Recipient
0769080 *
001216
Dow Getzendaner, ME Herman, JL Moss, RD
O
Distributees
Barrons, KC Boundy, RH Dow Elshere, D Falkensteln, WJ Hart, A Holder, BB Johnston, RV Jones, GD Kagy, JF K111an, DJ Luce, EN Lynn, GE McCollister, DD McIntyre, HH Moss, RD Mull Ison, HR Norton, TR P1tman-Moore Shrader, SA Wilson, AW Wright, N
Barrons, KC Baurledel, WR Dow Dowel 1, FH Hanson, RG Hymas, TA Johnston, RV Kagy, JF Lanlng, ER Ludwig, PD
Page 59 General Subject Matter Toxicological properties of her bicide formulation M-2993 con taining 4-am1no-356-tr1chloroplcoUnlc acid, Isooctyl ester and 245T polypropylene glycol butyl ether ester
A residue study plcloram and 245T 1n grass from application of M-3060 formulation (GH-C 343)
Dow Number
Date
Author
Recipient
07690810769082*
07690830769085*
670410 661205
07690860769087*
661108
07690880769094*
07691600769162*
660816 670316
Dow
Dow 01 son, KJ Oyen, F Wllson, H
Dow Hoyle, HR 01son, KJ Oyen, F Wllson, H
Dow Wllson, H
01son, KJ Oyen, F
O
Co
)
Distributees Moss, RD Osborne, DW Popoff, FP Ridner, JM Rowe, VK Seymour, KG Shaver, RJ Spalding, JL Williams, CS
Dow Lynn, GE
Boundy, RH Buerge, TE Dean, P Dow Elshere, D Holder, BB
General Subject Matter
Page 60
M-3060, safety data sheet
Results of range finding toxicolo gical tests on Esteron O.S. (M--3094) (T2.3094-1)
Esteron 245 O.S. (Data sheet of properties, health hazards and precautions for safe handling of materials)
Esteron 245 O.S. (M-3094) Toxico- ;
logy work sheets
?
Toxicological properties and
Industrial handling hazards of
Tordon 105 mixture^
(T2.MO-3132-1)
) )
Dow Number
Date
Author
Recipient
07691630769179*
660000
07692680769271*
671224
07692720769297*
680104
Dow Tinker, B Wilson, H
Dow M cCollister, DD Olson, KJ
Dow Lynn, 6E Olson, KJ
ho
) )
Distributees
Jones, GD Kagy, JF K llla n , DJ Luce, EN Lynn, GE McIntyre, HH Moss, RD Sheetz, DP Shrader, SA Wilson, AW Wright, N
Boundy, RH Dean, P Dow Elshere, D Hoider, BB Jones, GD Kagy, JF Luce, EN McCollister, DD McIntyre, HH Moss, RD Olson, KJ Robinson, VB
General Subject Matter
Page 61
Tordon 105 mixture {Toxicology worksheet)
Tordon 144 mixture data sheet of properties, health hazards and precautions for safe handling
Toxicological perpertles and Industrial handling hazards of Tordon 144 mixture herbicide
>
Dow Number
Date
Author
Recipient
07693510769352*
690121
Dow Hoyle, HR Norris, JM
07693530769354*
700130
07693550769356*
07700430770058*
to
CM-
681213 571122
Bjork, C Dow Gowel1, JH JBD Loucks, MF Nagele, RE Newport, JJ Seymour, KG Sheldon, HW Stein, JS Talcott, AT Williams, CS Wolf, MA
Dow Norris, JM
Dow Olson, KJ
>
)
Distributees Sheetz, DP Shrader, SA Wilson, AW Wright, N
I
General Subject Matter
Page 62
M-3199X Tordon 225 mixture her bicide data sheet of properties, health hazards and precautions for safe handling of materials. (T2.M0-003199-1)
Tordon 225 herbicide release to sales
All Inson-, RL Athay, RM Beshgetoor, AW Boundy, RH
M-3199X Tordon 225 herbicide v (T2.M0--003199--(1)), safety data > sheet
Results of range finding toxicolo gical tests on Brush K ille r X, Weed K ille r X and Brush K ille r TX
Dow Number
Date
Author
Recipient
07700440770045*
571115
07700470770048*
571115
^ 0770049 *
faOs
000000
Dow M cCollister, DD Olson, KJ Peterson, JE
Dow M cCollister, DD Olson, KJ Peterson, JE
Dow
)
;\
Distributees
Colby, RW Dosser, RC Dow Elshere, D Gay, HH Greene, LM Hart, A Hymas, TA Jones, GD K ilia n , DJ Luce, EN Martin, D McCollister, DD McIntyre, HH Mussel 1, DR Perkins, RP Tisdale, WL White, LC Wright, N
General Subject Matter
Page 63
Brush K ille r TX (Data sheet of
properties, health hazards and
precautions for safe handling of
m a te rla ls)'
v>
Weed K ille r X (Data sheet of pro perties, health hazards and pre
cautions for safe handling of materlals)
Brush K ille r X (Data sheet of properties, health hazards and precautions for safe handling of materials)
)I )
Dow Number
07700500770052*
Date 571115
0770059 *
560308
07700600770061*
07700620770063*
07700640770065*
560424 560521 571115
07706650770684*
660526
Author
Recipient
Dow McCollister, DD Olson, KJ Peterson, JE
Dow White, LE
Dow
Dow
Dow McCollister, DD Olson, KJ Peterson, JE
Dow Stevenson, GT Stock, BL
07817910781794*
501017
Dow Rowe, VK
o
"S i
Allen, WW A lquist, FC B ritton, JW
Dosser, RC Dow
)) )
I
Distributees
BLS GTS KJO RJS RMS RVJ TAH VBR
Page 64
General Subject Matter
Brush K ille r X (Data sheet of pro perties, health hazards and pre cautions for safe handling of material s)
Brush K ille r TX (Request for application testing)
Brush K ille r TX (Eye contact test)
Brush K iile r TX (Skin contact irritation)
Brush K ille r TX (Data sheet of properties, health hazards and precautions for safe handling of materials)
A summary of acute oral toxicity LD50 studies in poultry from TOX-37 thru TOX-66 inclusive (GH-A 186)
Results of skin ir rita tio n and skin sensitization tests conducted on human subjects with Esteron 245 (New Ester) (T2.30-3-1)
)
Dow Number
Date
0781795 *
500405
07817960781810*
530217
hO 4
00
Author
Dow REW Streeter, LE Dow Oyen, F
Recipient
Dutton, WC Irish , FN Kagy, JF Lynn, GE
Dow White, L
Allen, WW Alllnson, RL A lqulst, FN Beshgetoor, AW Boundy, RH Britton, EC Britton, JW Collier, B Davidson, JH Dow Dutton, WC Gay, HH Gibson, J Greene, LM Heath, SB Johnson, JE Kagy, JF K e lly, JA Krlner, RR Luce, EN Lynn, GE MacCutcheon, SM Mel ass, VH Nation, HA
)) )
I
Distributees
General Subject Matter
Page 65
Esteron 245T (Main lab report sheet)
Results of range finding toxicolo gical tests on Esteron 245 (T2.30-3-2)
>;
Dow Number
Date
Author
07820850782091*
531030
Dow Oyen, F
Recipient
0t1s, CE Predergast Southwlck, L Sunderland, WW Vanhorn, JC Walker, H White, LC Wright, P Zuhl, HH
0782092 *
Mo
530305
Dow Rowe, VK
)] }
I
Distributees
General Subject Matter
Page 66
Allen, WW AlUnson, RL A lqu lst, FN
Barrons, KC Beshgetoor, AW Boundy, RH Britton, EC Davidson, JH
Dow Dutton, WC Gay, HH
Greene, LM Kagy, JF Luce, EN Lynn, GE
MacCutcheon, SM Prescott, RF Sunderland, WW White, L Wright, P
Results of range finding toxicolo gical tests on Dow Brush K ille r T
V v
Dow Brush K ille r T (Request for biological test)
Dow Number
Date
07820930782100*
530000
07821010782103*
07821040782112*
07821130782114*
0782115 *
530000 530000 700721 000000
07821160782117*
710714
07821180782119*
07821780782198*
710920 560501
Author
Spencer, HC White, L
Dow Wolf, MA Wyse, H
Dow Wyse, H
Dow Wyse, H
Dow HCS
Dow
Recipient
Dow Hoyle, HR Wolf, MA
Dow Wolf, MA
Dow M cCollister, DD Torkel son, TR
o ro o
)
Distributees
General Subject Matter
Page 67
Alllnson, RL Beshgetoor, AW Boundy, RH Britton, EC Coulter, LL Dow
Dow Brush K ille r T (Acute oral toxicity)
Brush K ille r T (Eye Irritation )
Brush K ille r T (Skin Irritation )
Brush K ille r T, safety data sheet
Brush K ille r T (Medical Information)
Brush k ille r T (Data sheet of properties, health hazards and precautions for safe handling of materials)
Brush K ille r T (Medical Information)
Results of range finding toxicolo gical tests on M-631 (Esteron 245 type formulation) (BC T2.30-67-1)
Dow Number
Date
Author
Recipient
07821990782200*
580916
0782201 *
560504
Dow Hoyle, HR Torkel son, TR
Dow
07822020782220*
560409
Dow McCol11ste r, DD Wolf, MA
tOo
))
)
>
Distributees
Elshere, D Gay, HH Greene, LM Hart, A K111an, DJ Luce, EN MacCutcheon, SM Martin, D Scoles, G Sunderland, WW Wright, N
AlUnson, RL Beshgetoor, AW Boundy, RH Britton-, EC Colby, RW Dow Elshere, D Gay, HH Greene, LM Hart, A Kagy, JF Kelly, J
General Subject Matter
Page 68
Esteron 245 type formulation (M-631) (Data sheet of properties, health hazards and precautions for safe handling of materials)
M-631 (Esteron 245 type for mulation) (T2.30-67-1), safety data sheet
Results of range finding toxicolo gical tests on 2 formulations of Reddon (M-640 and M-713)
v
y
}
Dow Number
Date
Author
Recipient
07822850782306*
560503
Dow Lockwood, D
McColHster, DD Torkel son, TR
07823790782393*
560702
Dow Lockwood, D McColHster, DD
Olson, KJ
)} )
Distributees
K1l1an, DJ Luce, EN Lynn, GE MacCutcheon, SM Sunderland, WW Wright, N
AlUnson, RL Beshgetoor, AW Boundy, RH Britton, EC Coulter, LL Dow Elshere, D Gay, HH Greene, LM Hart, A K111an, DJ Luce, EN MacCutcheon, SM Martin-, D Scoles, G Sunderland, WW Wright, N
A lllnson, RL A lqulst, FN Barrons, KC Beshgetoor, AW Boundy, RH B ritton, EC Colby, RW Dow
General Subject Matter
Page 69
Results of range finding toxicolo gical tests on M-697 (Esteron
Brush K ille r type formulation) (T2.30-66)
Results of range finding toxicological tests on Esteron Brush K ille r OS (M-726) (T2.30-71-1)
Dow Number
Date
Author
Recipient
07869420786954*
07869550786975*
07870000787030*
09703300970343*
0979734 *
000000 000000 680122 700901 670914
0979735 *
670914
0979736 *
670914
Dow
Dow
Delong, HC
B la ir, EH Dow EMS
EMS
EMS
14023
))
}
Distributees
Eishere, D Gay, HH Greene, LM Hart, A Kagy, JF Kelly, JA K ilia n , DJ Luce, EN Lynn, GE MacCutcheon, SM Sunderland, WW Wright, N
General Subject Matter
Page 70
24D Esters-process information
Direct Ester process
Acid Ester operating instructions 489 Bldg
Chemistry of the Dow agricultural
department
k
Chloroacetic acid plant unit ratios
Crystalline chloroacetate acid unit ratios.
Butyl chloroacetate plant unit ratios
Dow Number
09799890979994*
12321171232129*
Date 670417
570806
12321301232143*
600331
Author
Recipient
Del Isle, NG EMS
Dow McCol lis t e r , DD
Wolf, MA
Dow Olson, KJ Oyen, F
1232355^ 1232378*
tfv-
571122
Dow McCol lis t e r , DD Olson, KJ
)>
Distributees
Barrons, KC Boundy, RH Colby, RW Dow Elshere, D Gay, HH Greene, LM Hammer, OH Hart, A Hymas, TA Jones, GD Kagy, JF K ilia n , DJ Luce, EN Lynn, GE McIntyre, HH Scoles, G Stenger, VA Tisdale, WL Wright, N
AlUnson, RL A lliso n , WE Athay, RM Beshgetoor, AW Boundy, RH
Page 71 General Subject Matter Flow sheets on 24D butyl ester acid Results of range finding toxicolo gical tests on Ml 086 (A 245T and 24D alkyl amine formulation) Results of range finding toxicolo gical tests on agricultural chemi cal formulation Ml639 (Veon Brush K ille r type)
r
Results of range finding toxicolo gical tests on Brush K ille r X, Weed K ille r X and Brush K ille r TX
) )
Dow Number
Date
Author
Recipient
12982971298299*
741204
1298300 *
640921
12983011298302*
129833 * ,,K, `
ro
000000 000000
Dow JNJ
Dow EMS Dow
Dow
)
}
D1strlbutees
Colby, RW Dosser, RC Dow Elshere, D Gay, HH Greene, LM Hart, A Hymas, TA Jones, GD K1l1an, DJ Luce, EN Martin, D McIntyre, HH Mussel 1, DR Perkins, RP Tisdale, WL White, LC Wright, N
i)
General Subject Matter
Page 72
2-(2-4 dlchlorophenoxy) proprlonlc acid (Physical properties data sheet)
Dowanol Ester of 245T (Physical properties data sheet)
SHvex (Physical properties data" sheet)
24D NA s a lt monohydrate (Physical properties data sheet)
)))
Dow Number
12983041298305*
1298306 *
12983071298309*
12983101298312*
Date 681030 741202 730315 490720
12983131298315*
680826
Author
Dow Erickson, AC
Dow JNJ
Dow
Dow BFW WJC Luce, EN Waling, BF
Dow JJ RH Stobby, G
Recipient
Dow Schrauf, B
12983161298320*
731128
Dow Messing, S
Dow Hart, JP
t
o
02
) )
Distributees
J)
Page 73 General Subject Matter 245-Trlchlorophenol (Physical pro perties data sheet) 245T (Physical properties data sheet)
2Freezing point molten 24D H O
24D report sheet (Main lab No. SSR 146-851)
Colby, A Dow Hoi deman, GE K1ley, L Shrader, S Wengert, GB
Arestln, Blelwelss, J Chase, F Dhlngra, Y Dow Haberstroh Jones, W Lafevor, D Manfrom, R Martin, R M iller, B
Herbicides, vapor pressure data (Analytical laboratories report AL 79-202)
24D acid ester process solubllItles
Dow Number
Date
Author
Recipient
12983211298322*
670327
12983231298326*
691022
1298328 *
710917
1298329 *
720615
Dow S t u ll, DR Walker, LC
Dow S1nke, GC S t u ll, DR
Dow G ilbert, PW Hawley, HM Hoi deman, GE Loucks, MF MacDonald, LA Relgler, PF Talcott, AT
Blosser, KC Chase, FT Dow Flannery, RF Fraser, JM G111, HH Hoff, RC Hoi deman, GE Talcott, AT Woodward, R
) )
Distributees
M1ntz, M Morehouse, DS Yeager, L
Dow Fernander, J
Holdeman, GE
Dow G ilbert, PW Hawley, HM Holdeman, GE Loucks, MF MacDonald, LA Relgler, PF Talcott, AT Tree, RM
Blosser, KC Chase, FT Dow Flannery, RF Fraser, JM G i l l , HH Hoff, RC Talcott, AT Woodward, R
General Subject Matter
Page 74
Thermal data for process steps 1n synthesis of 24D (HL-304)
Heat of reaction of dimethyl amine and 24D (HL-527)
2,4-D1chlorophenol, technical (product specification)
245T propylene glycol butyl ether esters (Product specification)
V r
)))
)
Dow Number 1298330 *
1298331 *
Date 720615
710118
1298332 *
730412
1298333 *
710601
Cv " ."-i'
00
Author Dow
Recipient
Chase, FI Dow Hawley, HM Hoi deman, GE Loucks, MF MacDonald, LA Reigler, PF Seymour, KG Ta1t, SR Talcott, AT Woodward, RE
Blosser, KC Chase, FI Dow Flannery, RF Fraser, JM Hoff, RC Hoi deman, GE Seymour, KG Talcott, AT Woodward, RE
Chase, FI Dow Hawley, HM Hoi deman, GE Loucks, MF MacDonald, LA
)I
Distributees
Chase, FI Dow Hawley, HM Hoi deman, GE Loucks, MF MacDonald, LA Relgler, PF Seymour, KG Ta1t, SR Talcott, AT Woodward, RE
Blosser, KC Chase, FI
Dow Flannery, RF Fraser, JM Hoff, RC Hoi deman, GE Seymour, KG Talcott, AT Woodward, RE
Chase, FI Dow Hawley, HM Hoi deman, GE Loucks, MF MacDonald, LA
Page 75
General Subject Matter
245T propylene glycol butyl ether esters (Sales specification)
Formula 40 Weed k ille r M-3604 (Product specification)
DMA-6 unsequestered M-2255 (Product specification)
DMA-6 sequestered M-3637 (Product specification
V
)))
;
Dow Number
Date
1298334 *
000000
1298335 * 1298336
000000 000000
Author
Relgler, PF Seymour, KG Ta1t, SR Talcott, AT Woodward, RE
Dow
Recipient
Dow Dow
1298337 * 1298338 *
1298339 *
1298340
1298341 *
| w* ik
1OX1
000000 000000 000000
710316 720117
Dow
Dow
Dow
Dow
Blosser, KC Chase, FI Dow
)
Distributees Relgler, PF Seymour, KG Ta1t, SR Talcott, AT Woodward, RE
Blosser, KC Chase, FI Dow
>)
General Subject Matter
Page 76
Propylene glycol butyl ether esters of Sllvex (Physical properties)
Isooctyl esters of 245T (Physical properties)
Low v o la tile esters of 245T Dow sales grade 245T, propylene glycol (C3H60 to C9H1803) butyl ether esters (Physical popertles)
Isooctyl esters of 24D (Physical properties)
N-Butyl ester of 24D (Physical properties)
24D Butyl esters (Physical properties)
24D propylene glycol butyl etHier ester (Product specification)
24D (Product specification)
Dow Number
Date
1298342 *
000000
Author
Flannery, RF 6111., HH Hoff, RC Hoi deman, 6E Scoles, GW Talcott, AT Woodward, RE
Dow
Recipient
12983431298344*
611017
1298345 *
000000
Dow Hoyle, HR Olson, KJ
Dow
12983461298347*
570927
12983481298349*
1298350 *
000000 741202
Dow Hoyle, HR Peterson, JE
Dow
Bethke Boust, HF Dersnah
) )
Distributees
Flannery, RF G111, HH Hoff, RC Hoi deman, GE Scoles, GW Talcott, AT Woodward, RE
II
General Subject Matter
Page 77
Tordon 101 mixture (Data sheet of properties, health hazards and precautions for safe handling of materials)
Dowanol PIB mix ester of 24D (Data sheet of properties, health hazards and precautions for safe handling of materials)
245-Tr1chlorophenol (Data sheet of properties, health hazards and precautions for safe handling of materials)
24D (Data sheet of properties, health hazards and precautions for safe handling of materials)
Consequences of overexposure for v chemicals 1n 489 building
B1s-(24D) (Reactive chemical hazard data)
J ;)
Dow Number
Date
1298351 *
750109
1298352 *
700801
1298353 * 1298354 *
741211 750123
1298355 *
750123
1298356 *
750123
12983571298360*
12983611298362*
1
O
741204 710526
Author
Dow Jones, W
Dersnah Dow Fey, K
Abegg, CF Dow Harris, VI Higgins, HS
Woznlak, LJ
Dersnah Dow Jones, JN, J r .
Dersnah Dow Jones, JN, J r .
Dersnah Dow Jones, JN, J r.
Dow Jones, J
Boggs, GU Dow
Recipient
Dow Dunlap, R Haberstroh, WH Higgins, HS Thels, JM
} )
Distributees
) )
General Subject Matter
Page 78
Ethylene Glycol W/ 24D acid; molten 24D process (Reactive che mical hazard data)
24D (Reactive chemical hazard data)
DE waste treatment plant
Waste treatment, butyl ester of 24D, d is tilla tio n feed (Reactive chemical hazard data)
Waste treatment, butyl ester of 24D solvent (Reactive chemical hazard data)
Waste treatment of butyl ester of 24D tars (Reactive chemical hazard data)
Alcohols, and molecular weight data summary
Direct ester MT" waste 710309 from 489 (Analytical laboratories report AL28-830)
) ) )) )
Dow Number
12983631298369*
12986031298605*
12986061298607*
Date 730000
000000 650119
12986081298609*
650125
12986101298611*
12986121298614*
12986151298617*
12986181298620*
12986211298623*
05
VO
740300 780601 780601 780601 780601
Author
Dow Southwlck, L
Dow
Dow Hoyle, HR Olson, KJ Oyen, F
Dow Hoyle, HR Olson, KJ
Dow
Iec1p1ent
Dow
Dow
Dow Dow
)) )
)
Distributees
Page 79
General Subject Matter
Kuron Silvex herbicide continues to gain acceptance (Ind vegetation mgnt 5(2), 18-24)
Properties and hazards, flash points of various products
Tordon 50D formulation (Data sheet of properties, health hazards and precautions fo r safe handling of materials) (T2.M0-2777X-1)
Tordon 101 mixture (Data sheet of properties, health hazards and precautions for safe handling of materials) (T2.MO-2439-1 )
Tordon 101 mixture weed and brush k ille r (Material safety data sheet) (Form 336-158-74)
Tordon (R) 101 mixture weed and brush k ille r (Material safety data sheet)
Tordon (R) 101 mixture weed and brush k ille r private label (Material safety data sheet)
Tordon (R) 101R forestry herbicide (material safety data sheet)
Tordon (R) 155 mixture brush k ille r (Material safety data sheet)
J)
)
Dow Number
12986241298625*
Date 660412
12986261298627*
12986281298629*
740300 660201
12986301298632*
12986331298634*
780601 671031
12986351298636*
760800
12986371298638*
12986391298640*
O os CO
12986411298643*
780601 771001 780601
Author
Recipient
Dow Hoyle, HR M cCollister, DD Olson, KJ
Dow
Dow Hoyle, HR McColllster, DD Olson, KJ
Dow
Dow Hoyle, HR Norris, JM Olson, KJ
Dow
Dow Dow Dow
)) )
.)
Distributees
Page 80
General Subject Matter
1 Tordon 155 (Data sheet of pro perties, health hazards and pre cautions for safe handling of materials) (T2.MO-2993-1)
Tordon 155 mixture brush k ille r (Material safety data sheet)
Tordon 202 mixture (Data sheet of properties, health hazards and precautions for safe handling of materials) (T2.M0-2861-1)
Tordon (R) 202C mixture herbicide (Material safety data sheet)
Tordon 212 (Data sheet of proper t ie s , health hazards and pre cautions for safe handling of materials) (T2.M0-3200-1)
Tordon 212 mixture herbicide (Material safety data sheet) (Form 336-161-76)
Tordon (R) 212 mixture herbicide ] (Material safety data sheet)
Tordon (R) 225 herbicide (Material safety data sheet)
Tordon (R) 225E mixture herbicide (Material safety data sheet)
) )
Dow Number
12986441298651*
Date 750811
12986521298653*
700514
12986541298655*
750600
12986561298658*
12986591298660*
780601 710422
12986611298662*
710917
12986631298664*
750310
O 12986651298666*
760823
Author
Dow Gutenkunst, V Porter, DF Skelly, NE
Dow Hoyle, HR Norris, JM
Recipient
Dow
Dow
Dow Hoyle, HR Norris, JM
Dow Hoyle, HR Wolf, MA
Dow Silverstein, LG Wolf, MA
Dow Langner, RR
))
)
Distributees
Page 81
General Subject Matter
Analytical method Tordon 225E mix ture herbicide by liq u id chroma tography (Method 87141)
Tordon 472 herbicide (Data sheet of properties, health hazards and precautions for safe handling of materials) (BC12.MO-3427-1 )
Tordon 472 herbicide (Material safety data sheet) (Form 336-166-75)
Tordon (R) 472 weed k ille r (Material safety data sheet)
DMA4 (Data sheet of properties, health hazards and precautions for safe handling of materials) (NB T2.MO-3538-1)
245T Dowanol 97B ester (Data sheet of properties, health hazards and ; precautions for safe handling of materials) (K-7856 NB725.14-106) J
24D Triisopropanolamine salt (Data sheet of properties, health hazards and precautions for safe handling of materials) (K-8866)
DMA-6 (Data sheet of properties, health hazards and precautions for
)) ) } )
Dow Number
Date
1298667 *
12986681298670*
12986711298672*
000000 760800 710917
12986731298674*
650125
12986751298676*
690909
12986771298678*
650119
12986791298680*
660412
Author Wroblewski, D
Recipient
Dow Lamott, S
Dow
Rafos, G
Dow Hoyle, HR Wolf, MA
Dow Hoyle, HR Olson, KJ
Dow Hoyle, HR Norris, JM
Dow Hoyle, HR Olson, KJ Oyen, F
Dow Hoyle, HR McColllster, DD Olson, KJ
)
D1stributees
Page 82
General Subject Matter
safe handling of materials) (M--3637)
Cover memo for data sheets
Tordon 212 mixture herbicide (Material safety data sheet) (Form 336-161-76)
245T Dowanol 97B ester (Data sheet of properties, health hazards and precautions for safe handling of materials) (K-7856 NBT25.14-106)
Tordon 101 mixture (Data sheet of properties, health hazards and precautions for safe handling of materials) (T2.MO-2439-1)
Tordon 472 herbicide (Data sheet of properties, health hazards and precautions for safe handling of materials) (BC T2.M0-3472-1)
Tordon 50D formulation (Data sheet * of properties, health hazards and t precautions for safe handling of materials) (BC T2.M0-2777X-1)
Tordon 155 (Data sheet of proper tie s , health hazards and pre cautions for safe handling of material s ) (T2.MO-2993-1 )
Dow Number
12986811298682*
Date 751009
Author
Dow Hoyle, HR Yakel, HO
Recipient
12986831298684*
700319
Dow Hoyle, HR Norris, JM
1298685 *
12986861298689*
1298690 *
750711 750711 711116
12986911298692*
1298693 *
000000 741031
12986941298695*
690716
Dow Krumel, KL
Dersnah, H Dow
Brown, M Dow JL Robb, J
Dow
Dow Hebbourn, R Kerby, JE
Dow
Dow Krumel, KL
II )
)
)
Distributees
Page 83
General Subject Matter
Tordon 212 mixture herbicide (Data sheet of properties, health hazards and precautions for safe handling of materials) (HET M--3179-(2))
Tordon 212 mixture herbicide (Data sheet of properties, health hazards and precautions for safe handling of materials) (T2.M0-3179-1)
24D (Reactive chemical hazard data)
Dust explosion properties of 24D acid (Analytical report)
DMA-6 (unsequestered) (Reactive chemical hazard data)
24D (Summary of chemical react ilv it y precautions and properties)
24D PGBEE (Reactive chemical hazard data)
Tordon 212 mixture (Summary of
Dow Number
Date
12986961298697*
1298698 *
690716 750206
12986991298700*
1298701 *
691003 710830
12987021298703*
12987041298714*
690716 710125
1298715 *
710801
Author
Dullap, RL Mandrell, ME
Dow Dunlap, RL Mandrell, ME
Bethke Dersnah Dow Hoi deman, G Keeney, N Vanhorn, R
Dow G ilbert, PW Mandrell, ME
Dow CJR JRL RSS
Dow Dunlap, RL Mandrell, ME
Dow Prophet, H S tu ll, DR
Recipient
Dersnah, H Dow McCarty, WM
\) )
)
)
Distributees
Page 84
General Subject Matter
chemical re a ctiv ity precautions and properties)
Tordon 101 mixture (Summary of chemical re a ctiv ity precautions and properties)
Tordon 101 R (Reactive chemical hazard data)
Tordon acid (Summary of chemical rea ctivity precautions and properties)
Tordon 225 (Reactive chemical hazard data)
Tordon 155 mixture (Summary of chemical re a ctiv ity precautions and properties)
Studies of hazardous chemicals and th e ir reactions, kinetics of che mical destruction by burning (NCT-5007)
Esteron 245 CONC (Reactive chemi cal hazard data)
;)
)
Dow Number
12987161298717*
Date 690627
12987181298719*
690718
13394201339423*
650810
13418341341853*
700422
Author
Recipient
Dow G ilbert, PW Mandrell, ME
Dow G ilbert, RW Mandrel 1, ME
Barrons, KC Lynn, GE McCoy, WJ Southwlck, L Wolf, MA Vanvalkenburg,W
Sachs, SB Branaman, J G U I, WM Delong, HC Matutz, H Davis, H
Corbin, WL Johnson, J CEO DEP
Fauver, VA
MacDonald,LA
CD
toeo
i
Distributees
Page 85
General Subject Matter
Dowanol PIB esters of 245T (Summary of chemical reactivity precautions and properties)
24D TIPA mix (Summary of chemical reactivity precautions and properties)
Esteron TR2 (Release to Sales 12)
Demott, DN
Hanners, HH Martin, RA Tree, RM
Dellne, DD Kennedy, TL Robbins, LA Plepys, RA
High purity 245-tr1chlorophenol, v
state of the art review
i
)) )
Dow Number
Date
Author
Recipient
14107901410792*
701217
Dow Gehrlng, PJ Norris, JM Williams, CS
H*. 1410793^ 1410794*
to CO
701228
Dow Hoyle, HR Norris, JM
)
Distributees
Stamand, VE Clark, 6A Spencer, RA Dylewski, SW Ble1we1ss, JC
Barton, J B la ir, EH Burgert, BE Clegg, DH Dow Edwards, H Frevel, LK Gordon, HL Goring, Ca Holder, BB Johnson, JE K111an, DJ Klmmel, CE Lloyd, BH MacCutcheon, SM M cCollister, DD McIntyre, HH Morgan, RW Morse, D Pltchforth, L Robinson, VB Schwarz, BA Williams, CS
General Subject Matter
Page 86
Toxicological properties and Industrial handling hazards of
formulation M-3592 containing the propylene glycol butyl ether ester of 245T
i-
M-3592 (Data sheet of properties, health hazards, and precautions for safe handling of materials)
) )) )
Dow Number
14107951410798
Date 701217
Author
Dow Norris, JM
Recipient
14107991410800*
14108011410802*
14108031410804*
1410805 *
14108061410807*
14108101410811*
14108121410813*
14108141410815*
701119 701228 701110 701106 701210 701210 701210 701217
y r r t .
O
O-
Bourne, JE Dow S llversteln , EH
S llverstein , EG
Sllversteln , EH
S llve rste ln , EH
Sllversteln , EH
S llve rste ln , EH
Dow Gehrlng, PJ N orris, JM Williams, CS
)
Distributees
Bergert, BE Blair., EH CI egg , DH Dow Frevel , LK Gordon, HL Goring, CA
Page 87 General Subject Matter Acute toxicological properties of Formulation M-3592 containing the propylene glycol butyl ester of 245T M-3592 (Acute oral toxicity)
M-3592 (Acute oral toxicity)
M-3592 (Eye irrita tio n )
M-3592 (Primary skin Irritation patch test (household chemical)) M-3592 (Skin contact absorption)
M-3592 (Skin contact absorption)
M-3592 (Skin contact absorption)
Toxicological properties and Industrial handling hazards of formulation M-3592 containing the propylene glycol butyl ether ester of 245T
Dow Number
Date
Author
Recipient
14108161410817*
701217
14108181410821*
701217
Dow Hoyle, HR Norris, JM
Dow Norris, JM
14108221410823*
14108241410825*
14108261410827*
^ 1410828 *
O
701119 701228 701110 701106
Bourne, JE S1lverste1n, EH S11verstein, EH S ilverstein , EH
J
)
Distributees
Holder, BB Johnson, JE Klmmel, CE Lloyd, BH MacCutcheon, SM McCollister, DD McIntyre, HH Morgan, RW Morse, D Pltchforth-, L Robinson, VB Schwarz, AJ Williams, CS
General Subject Matter
Page 88
M-3592, (Data sheet of properties, health hazards and precautions for safe handling of materials)
Acute toxicological properties of formulation M-3592 containing the propylene glycol butyl ether ester of 245T
M-3592 (Acute oral toxicity)
M-3592 (Acute oral toxicity)
M-3592 (Eye Irritation)
M-3592 (Primary skin Irritation patch test (household chemical))
I ))
)
Dow Number
14108291410830*
14108311410832*
14108331410834*
14108351410836*
14108801410902*
Date 701210 701210 701210 701210 630225
Author
Recipient
SH versteln, EH
S llve rste ln , EH
S llve rste ln , EH
S llversteln , EH
Dow
Olson, KO Oyen, F Scoles, G
CD
to
) )
t
Distributees
Barrons, KC Boundy, RH Brown, R Colby, RW Dow Elshere., D Falkenstein, WJ Gay, HH Greene, LM Hart, A Jones, GD Kagy, JF K111an, DJ Luce, EN Lynn, GE McIntyre, HH Mullison, HR Nash, HA Norton, TR Scoi es , G Shrader, SA
Page 89 General Subject Matter M-3592 {Skin contact absorption)
M-3592 (Skin contact absorption)
M-3592 (Skin contact absorption)
M-3592 {Skin contact absorption)
Results of range finding toxicolo gical tests on agricultural chemi cal formulation M-2422 containing 91 percent Dowanol PIB ester of 245T (Biochemical Research Laboratory)
.) ) )
)
Dow Number
Date
Author
Recipient
14109031410909*
531030
Dreyer, F
14286101428611*
14312591431263*
O 1436354iG* 1436364*
611228 000000 000000
Dow Winston, AW, Jr.
Ivon Watkins
)
Distributees
Wilson, AW Wright, N
Adams, EM Allen, WW AlHnson, RL A lqulst, FN Barrons, KC Beshgetoor, AW Boundy, RH Britton, EC Davidson, JH Dow Dutton, WC Gay, HH Greene, LM Kagy, JF Luce, EN Lynn, GE MacCutcheon, SM Prescott, RF Sunderland, WW White, L Wright, P
General Subject Matter
Page 90
Results of range finding toxicolo gical tests on Dow Brush K ille r T
Fish to x icity of some herbicide formulations and their Ingre dients
IWD 245T Esters
v
Compounds showing toxicity to fish at 5 MG/L or less
)} )
)
Dow Number
14370601437102*
Date 660622
Author
Graves, HH DRE
Recipient
14439211443922*
701217
Dow Gehrlng, PJ Norris, JM Williams, CS
K4 o
lt*
)
Distributees
Goergen,GG Lueck,A Sauers, RC W1d1ger, AH Tuttle, FC Poffenberger, N Wolf, RR E lg stl, DR Hillman, RE Anderson, RE Graves, HE Coulter, KE Snyder, AP Del Isle, NG
Barton, J B la ir, EH Burgert, BE Clegg, DH Dow Edwards, H Frevel, LK Gordon, HL Goring, CA Holder, BB Johnson, JE K111an, DJ Klmmel, CE Lloyd, BH MacCutcheon, SM McCollister, DD McIntyre, HH Morgan, RW
Page 91 General Subject Matter P ilo t Plant Study of the Caustic Hydrolysis of 1245 Tetrachlorobenzene CF-1043-2
Toxicological properties and Industrial handling hazards of formulation M-3592 containing the propylene glycol butyl ether of 245T
V
)
Dow Number
Date
Author
Recipient
14439231443924*
701217
14439251443928*
14439291443932*
701217 700000
14439331443934*
1443935 *
761110 701106
14439361443941*
1511476 *
701210 800606
15515891551591*
V"4 . ot -
580417
Dow
Hoyle, HR Norris, JM
Dow Norris, JM
Bourne, JE Dow S1lverste1n, EH
Dow S llversteln , EH
Dow S llversteln , EH
Dow S llve rste ln , EH
K&E Wine, LM
Braun, WH Dow
Dow Stevenson, GT
)
Distributees Morse, D Pltchforth, L Schwarz, AJ Williams, CS
Dow Tucker, M Barrons, KC B la ir , EH Boundy, RH Colby, RW Coulter, LL
General Subject Matter
Page 92
M-3592 (Data sheet of properties, health hazards and precautions for safe handling of materials) Acute toxicological properties of formulation M-3592T M-3592 (Acute oral toxicity)
M-3592 (Eye Irritation)
Primary skin Irrita tio n patch test (household chemical) (M-3592) M-3592 skin contact absorption
Inverton (brush.killer) hay spray ca ttle feeding test
) )
Dow Number
Date
Author
Recipient
15685591568560
650000
Dow
15686271568630
15686661568667
641208 641208
Sauers, RC Sorge
1573474*
700915
Haberstroh, WH Savaso, JC
O" Ob-
))
Di stributees
Dow
Green, J
Hymas, TA
Johnson, JE
Kagy, JF
Lipple, LJ
Lynn, GE
Norton, TR
Nutting, HS
Perkins, RP
Rowe, VK
Spalding, J Vanvalkenburg,
JW
General Subject Matter
Page 93
Analysis of caustic Insoluble oil and 245 Trlchlorophenol for com position by gas liqu id chroma tography
Chronological survey of the f ir s t production period of 245T produc tion
Chronological, survey of the f ir s t production period of 245T production.
Blelwelss, JC
Deline, DD Henry, HE Hensley, EF
Schmidt, BV T e fft, TH
24D Capital Estimates
)
Dow Number
15734751573482*
15805421580566*
Date 700910
680514
15805671580585*
15819831582013*
15826541582657*
15836671583675*
15836901583691*
1630441*
680822 620700
000000 721125 500600
Author
Recipient
Haberstroh, WH Seidel, EM
JFL Kern, WG Fernandez Gorgasz Dal man
Dow
G1lzorr1lla, F FGZ CAH
McCauley, V Mathew, BA
M1llh1sler, RD
Vanhorn, R Bethke
1630444*
H 6,
1630446*
O
510228 501000
Dupont
Distributees
Page 94 General Subject Matter Revision of 24D Capital Estimates
Technology review of Industrial chloracetlc acid
Dowanol, Butyl 4 Isooctyl Chloroacetate technology review Preliminary engineering study for Dow Qulmlca Argentina, SA
Tordon 105 Manufacture
Tordon 225E
M3990 or Tordon 225E reactive chemical hazard data 24D Amine Weed K ille r (Raw materials description and specifications) Raw material specification 24D Amine Weed K ille r (Raw materials handling 4 storage conditions)
I
j
Dow Number
16304471630473*
1630466
Date 501000
500810
16304741630478*
16304791630483*
1630485*
491200 500201 500510
16304891630490*
491200
16304911630494*
491200
16426901642691*
16450901645098*
000000 550826
Author Ott, RC
Recipient
Jlrouch, EA Dupont
JRU
Bennett, CM W1d1ger, A Dugan, G
o
GO
)
Distributees
Griswold, A Williams, WH Britton, EC A lqu lst, FN Colby, A Vanarsdale, J Reese, R
')
Page 95
General Subject Matter
24D Amine Weed K ille r (operating directions)
Effect of DMA Concentration on PH of 24D Amine Weed K ille r
24D Amine Weed K ille r (Operational hazards)
Tentative Operating Instructions, Dimethyl amine
24D Amine Weed K ille r Specifications & average analysis
24D Amine Weed K ille r (Labor Required for Operation).
24D Amine Weed K ille r (Production and Yield Accounting Methods and Information)
Trlchlorophenol Manufacturing
Phenol, 245 Trlcholor
*
)
Dow Number
Date
Author
Recipient
16500791650081*
630429
16501391650141*
670522
tOP*
ZD
Barrons, KC Coulter, LL Johnson, JE Lynn, GE Wolf, MA Hunt, M Loucks, MF Vanvalkenburg, W Fayerweather, BL McIntyre, HH Branaman, J Lang, HC Falkenstein, WJ Davis, HW A llen, WW
Barrons, KC Byrd, BC Wolf, MA Gowel 1 Loucks, MF Falsey, MP Buerge, TE McIntyre, HH Hammer, OH G U I, WM H1ghh1ll, CA Woodward, RE
J ) >I
Distributees
Brainerd, A Poffenberger, N W1d1ger, A Dugan, G
General Subject Matter
Page 96
Verton CE with o il (Release to Sales)
Tordon 155 Mixture (Release to Sales 9)
V
)) I )
Dow Number
Date
16501461650148*
671009
Author
Davis, H Corbin, WF Nummy, WR DEP CJK JLS
Dow
Recipient Woodward, RE
1650262 1650264*
630517
16504661650468*
621012
Oo \
Barrons, KC Coulter, LL Johnson, JE Lynn, 6E R1tty, PM Wolf, MA Loucks, MF Vanvalkenberg,W Branaman, J Lang, HC Fai kenste1n, WJ Allen Saunders, ES
Amstutz, FC Barrons, KC Johnson, JE Lynn, GE Southwlck, L Wolf, MA
)
Distributees
)
General Subject Matter
Page 97
Dosser, RC Hoff, RC Matuska, R Colby, A
Stone, F
Sales Release Tordon 155 Verton T (Release to Sales 16)
Esteron 245 Concentrate (Proposed Release to Sales 21)
v
))
Dow Number
Date
17279671727968*
580630
17280491728050*
590702
17280531728054*
17280571728058*
17280591728060*
oCJS
630108 621214 660412
Author
Recipient
Vanvalkenberg.W McIntyre,HH Branaman.J Lang, HC Allen, WW JLS KEE
ES PMR Saunders, E
Dow McColHster, DD Wolf, MA
Dow Olson, KJ Oyen, F
Dow Olson, KJ Oyen, F
Dow Olson, KJ Oyen, F
Dow McCollister, DD Olson, KJ
I
)
)
Distributees
General Subject Matter
Page 98
Dow Hoyle, HR
Dow Hoyle, HR
Dow Hoyle, HR
Dow Hoyle, HR
Dow Hoyle, HR
Dow 245T amine weed k ille r (Data sheet of properties, health hazards and precautions for safe handling of materials)
M-1459 formulation of K-7797 and K-7856 (Data sheet of properties, health hazards and precautions for safe handling of materials)
M-2422 (Data sheet of properties, health hazards and precautions for safe handling of materials)
M-2468 (Data sheet of properties, :
health hazards and precautions forv
safe handling of materials)
'
M-2993 (Data sheet of properties, health hazards and precautions for safe handling of materials) (T2.MO-2993-1 )
)i
)
Dow Number
17280611728062*
Date 700514
Author
Dow Norris, JM
Recipient
17281011728102*
17281031728104*
580616 580630
17281671728168*
580514
1765919*
17663001766308
650919 661104
Dow McCollister, DD Wolf, MA
Dow McCollIster, DD Wolf, MA
Dow McColl!ster, DD Wolf, MA
Sinke, GC
Wldiger, AH Johnson, RL Dugan, GF
ocn
to
);
Distributees
Dow Falkenstein, WJ Hoyle, HR
Dow Hoyle, HR
Dow Hoyle, HR
Dow Hoyle, HR
Widiger, AH Coulter, KE Johnson, R Thurston, D Dugan, G Haberstroh, WH Goergen, GG Sauers, RC Bender, S Wolf, RR Louck, A
Page 99
General Subject Matter
M-3427 (Data sheet of properties, health hazards and precautions for safe handling of materials) (BC T2.MO-3427-1)
Reddon (Data sheet of properties, health hazards and precautions for safe handling of materials)
Reddon concentrate (Data sheet of properties, health hazards and precautions for safe handling of materials)
Veon brush k ille r (Data sheet of properties, health hazards and precautions for safe handling of materials)
Heat of reaction data per GC S1nke of the Thermal Lab
Phenol, 245 Trichloro study of Chloracne problem Preparation of 245 Trlchlorophenol from Trichlorobenzene
I)
Dow Number
Date
Author
Recipient
17663091766336*
650203
Poffenberger,N Bradley, K Ebert Warren
17666511766660*
17666811766686*
641125 650107
Poffenberger, N
CD
)) )
Distributees
Poffenberger, N Bailey, CZ Putnam, MS Nielson, WH StaehUng, EC
Bradley,K Graves, H Dylewskl , S Haberstroh, WH Sauers, R Trapp, W Poffenberger, N W1d1ger, AH Coulter, KE Goergen, GG Luecic, A Redmond, W Del Isle-, NG StaehUng, EC
Poffenberger, N Sauers, RC Trapp, WB W1d1ger, A Luecic, A Holmes, R Bradley, K Goergen, GG
General Subject Matter
Page 100
Phenol 245 Trlchloro Preliminary Process Design Using 100 percent NAOH, PL2028-4
Trlchlorophenol Process
245 Trlchlorophenol - Outline of Requirements
* *
> '
)
\
Dow Number
17666871766694*
Date 650112
Author
Recipient
Poffenberger, N
17666951766698*
650105
Poffenberger, N
17667041766708*
17667131766730*
641120 641224
Holmes, R Sorge
17667341766736*
691212
W1d1ger, A
Sauers Chang, KY
h*4
enfO-P*
1 )
>
Distributees
Poffenberger, N D e lisle , NG Sauers, R Trapp, WB Widlger, A Lueck, A Holmes, R Bradley, K Goergen, G
Poffenberger, N Sauers-, R Trapp, W Lueck, A Widlger, A Bradley, K Goergen, G Holmes, R
Leavlttg, FC Demott-, DN Poffenberger, N Tree, R Plepys, RA Schmidtke, DJ
Page 10]
General Subject Matter
Appendix to Report PL2028-3 (245 Trichlorophenol)
245 Trichlorophenol Process Information
Hydrolysis of Tetrachlorobenzene using flake caustic
Description and prints for th>e
current production methods fo r obtaining 245 Trichlorophenolate solution 1n building 74 {Report :50]
Progress report on research on blooming of 245 Trichlorophenol
) )
Dow Number
17667391766750*
Date 700720
Author
Chang, KY Tou, JC
Recipient
1766760 1766761*
641118
17667621766764*
17667661766769*
1766770-
enQ . 1766771*
640730 641120 000000
W1d1ger, AH Holmes, RD
Holmes, R
Holmes, RD
Dow
Grelss, GA Hoyle, HR
)
Distributees
Chang, KY Tou, JC Look, A Leavitt, FC Demott, DN Poffenberger, N Gum, WF Plepys, RA Pierce, JK Frevel , LK Potts, WJ Westover, LB Fauver, VA Kennedy, TL Widiger, AT Pews, G Rodla, RM Nummy, WR Blue, RD D e lisle , NG Sheetz, DP
Goergen, GG
Page 102
General Subject Matter
Oxygen 18 labeling study on the mechanism of caustic hydrolysis of 1245 tetrachlorobenzene 1n methanol
199 Bldg Production of Sodium 245 Trichlorophenate
Manufacture of Trichlorphenol at 199 Bui ding
Hydrolysis of Tetrachlrobenzene using flake caustic
TCP Process Flow Sheet
v