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Industrial Hygiene Digest :\ MAY 2- 1957 JOF INDUSTRIAL HEALTH NEWS LITERATURE ABSTRACTS MEDICAL ENGINEERING CHEMICAL TOXICOLOGICAL I.KGflTi daeialoiu *nd tznd APRIL, 1987 (Vol. 21, No. 4) INDUSTRIAL HYGIENE FOUNDATION MELLON INSTITUTE 4400 FIFTH AVENUE PITTSBURGH 13. PA. PLAINTIFF'S EXHIBIT WV-0046S SC-ALL-06960 r SCF-ALLF-01830 19! 7 ( NOUS TRIAL FIE NS ATURES Biological data which r*pr*s*nt* the correlated contribution* of more than 4,000 telcntiaU ud ibt cornuel of an additional 13,000. ; . AkitrutNg. 451. . i What cut be done about the *hortag* of phyaielana for Induetry 7.... . AbatractNo. 456. : Question* and anewer* on practical aapacta of occupational dtrmato***. Abatract No. 465. : . Circumstance* la which soaps and datargantahave been indictad sa cauatog or aggravating dermatitis ara roach more complex thaa have baaa aatlelpatad. Abatract No. 466. An evaluation, of the hazard* of ozone and osddes of nitrogen, and factors modifying their toxicity. * ' -Abatract No*. 474 and 475.' ' - ' Existing tendency to develop lung tumor* may have^ some'bearing la . pulmonary carcinoma, experiment exposing mica to aabaato* dust . indicate*. Abatract No. 506.. ' Hitherto unrteognixtd etiological ' . factor to calcification of the peri* ; 7 :< cardium revealed by cUnicoroent* v; ganalogic study of workers employed to tale miila and mines.; . Abatract No. 507. . How can the nuisance problem of aoiaa to air*condltiontog systems be slim* Lnated7 Abstract Nos. 513*5l7. V A proposed technique for measuring the noise ofa doctad faa aliatoataa maaaurtog errors caused by tha udatuco of bounding waves. ,, Abatract No.,510. i Wbat arc tha responsibilities of tha : medical profession to the use of x-rays and other ionising radiation? ' - Abatract No. 528. ;. :: : . ... A atody of a'multiple Venturi vat collectors. Abatract No. 541. A atndy of carctoogenidty of atmoa* phoric pollutant*., Abatract No.-. 545. to order to treat electric-are ateel furnace fume theoretically, accurate particle else distribution* for each phaaa of the melting cycle muat be Imown. Abstract No. 548. How to.go. about hiring handicapped people and placing them in productive work. Abatract No. .353.;, 1 . Safety! sudade* to their present form are only oar indication of what a.tklaty program la doing. - ;. . Abstract No. 554. ' ;I 'I ^^'fStDATION" FACTS 'w, Volume 19 t 'ii -.: .;*/,* .%;; -..- April, m7 ^ SCHREWK1UCCEIVES C1TMMQIOS : Sr. H.-H, Schrehlc.'Research Director i Dr. Schrenk hasdlrected envtrouneaUi Vt^tea'l(i^^MiH^Qik6u^b(i the United States andCanada aed has.been In charge' of^idpo*" . ^ . and hloloj^Leal resosjfih'ipiujjrie^M^* the Foyi^a^^^^/,r i"A~J-*r --"^"'''`'Tdli'ected laborat^^it^d, ^e'^ebr^.v^^r^gu^ons^u^T^-. '.^ear be joined tbe .CkMamis^ thettaiuSi&i B mmm 2&&ti agifticireeonaoce,-; . . 1 morrconrentlonalanaly#c ^^V^M^rdevelopments li :eiei^ MMtlUaVmiML **"' * " **" Industrial Hygiene Digest April. 19 carborundum tor sanding in the shoe industry; and slate or chalk tor stone-dusting in ct mines. Quarts sands have been prohibited since 1938 in grinding of glass, and exposur has been regulated. The higher cast of artificial abrasives in the glass and ceramic im tries is offset by higher working speed. -- Cond. from Bull. Hyg 503 Respiratory Symptoms and Pulmonary Disability in an Industrial Town. Survey of a Random Sample of the Population. I T. T. Higgins, P. dT Oldham, A. L. Cochrane, andJ. C. Gilson. Brit. Med. J. Z\ 904.910 (Oct. 20, 1956). In 1954 the Pneumoconiosis Research Unit of the Medical Research Council carried out a survey of the male population aged 55 *64 of Leigh in Lancashire, in order to compare the prevalence of respiratory symptoms and disability in miners with that found in men who had worked only in other occupations. The random sample consisted of 135 miners and ex-miners and 85 non-miners. Pneumoconiosis was found in 23% of the miners and ex.miners. Chronic bronchitis was found in 10.7% of the non-miners, in 26. 7% of the miners without pneumoconiosis, and In 12. 9% of the miners with evideuc of pneumoconiosis. Some of the conclusions are; (1) miners and ex-miners had signifi cantly more chronic bronchitis, a lower ventilatory capacity, and more respiratory symptoms.than men who had never worked in mines; (2)miners without pneumoconiosis were on the average more disabled than those with early simple pneumoconiosis; and (3) the differences between miners and non.miners could not be ascribed to differences in social class or smoking habits, and in the miners there was no obvious relationship between length of exposure to dust and bronchitis. -- Cond. from Bull. Hyg. 504 The Influence of the Shape of Dust Particles on the Rate of Phagocytosis in Vitro, A. Lengerova, V. J. Longer, M. Esstova, R. Tuscany, and M. Voitova. Brit. J. tod. Med. 14, 43-46 (Jan. 1957). The rate of phagocytosia of two shapes of dust particles--''long" and "round" -- was studied in an investigation in vitro in cultures of macrophages from th spleen of chicken embryos. The round particles were phagocytosed preferentially. This result is discussed from the standpoint of existing theories of phagocytosis as well as from that of the relation of the rate of phagocytosis and the harmfulness of different kinds of dusts. -- Authors' summary 505 The Prevalence of Tuberculosis at Necropsy in Progressive Massive Fibrosis of Coalworkt D. Rivers, W. R. L. James, D. G. Davies, and S. Thomson. , Brit. J. tod. Me#d. *1*4' , 39-42 (Jan. 1957). . One hundred .litty-thooe-caveswf coalworkers' pneumoconiosis were examined at necropsy tor the presence of tubercle bacilli both by culture and by animal inoculation. The series contained 118 cases of progressive massive fibrosis which were the special object of this study. Tubercle bacilli were isolated from 41 cases (35%) of massive fibrosis, and in 31 (28%) of these naked-eye or histological evidence of tuberculosis was recognised patho logically. The pathological observations, therefore, correlated well with the bacteriologies results. There is a marked difference between the prevalence of tuberculous Infection found in a post-mortem series and that found in life in cases of progressive massive fibrosis. During life the observed prevalence is only 1.1%, The authors found tubercle bacilli In the bronchi at necropsy,in 28%. Thus open tuberculosis is, iu most cases, s late complication of massive fibrosis. Whether tuberculous infection occurs early or late cannot be deduced from this study. . -- Authors' summary 506 Pulmonary Tumors in Mice Exposed to Asbestos Dust. K, M. Lynch, F. A. Melver, and J. k. Cain. Arch. ind. Health IS, 207-214 (Mar. 1957). Mice of a selected strain (AC Fj) were exposed to a dusty atmosphere containing asbestos floats of a type.used by others experimentally, at 150 to 5.00 million particles per ' cubic toot. The largest single experimental group consisted of 127 animals killed at 19 months after exposure for 17 months. This group was compared with 222 control animals. Primary lung tumors were demonstrated microscopically in 46% of the dusted mice and in j^ial Hygiene Digest April, 1957 ol the controls. Multiple pulmonary tumors were demonstrated in 18% o[ the dusted animals and in 8% of the control animals. No significant histologic or cytologic difference was observed between tumors in the two groups. No clear-cut proof of malignancy was found in any of the lung tumors studied. The authors have been unable to demonstrate any proof of the carcinogenicity of asbestos under the conditions of the experiment, but the increased incidence of multiple lung tumors in dusted animals must be regarded as a possi ble accentuation by the inhalation of asbestos dust of an existing tendency to develop lung tumors. Future experiments with asbestos should include the use of larger animals, prob ably monkeys. The equivocal nature of this report does not answer the questions raised by accumulating clinical evidence that asbestosls is strpngly associated with, and therefore is a possible cause of, pulmonary carcinoma in man. -- Adapted from authors' summary Calcification of the Pericardium Caused by a Hitherto Unrecognized Etiological Factor. M. Kleinfeid and C. P. Giel. Am. Heart J. ST, 899-904 (Dec. 1956). In a clinicoroentgenologic study of workers employed in talc mills and mines, calcification of the pericardium was observed in 3 of 37 workers. In one patient the condi tion had existed for 15 years. The advanced age of these patients (79, 68, and 64 years) is in contrast to that found in chronic constrictive pericarditis, where the age range reported has varied from* 10 to 59 years. Cardiac enlargement was absent, and the electrocardio graphic patterns were essentially normal. The clinical picture revealed a chronic, slowly progressive course, with the predominant symptoms of pulmonary insufficiency consistent with the average course of talc pneumoconiosis. The normal electrocardiograms, lack of evidence of failure of either side of the heart, lack of response to nitroglycerin, and the absence of any intensifying effect of effort would tend to exclude angina pectoris. The exact mechanism responsible for the calcification of the pericardium in exposure to talc is not known. It can best be explained by a mechanical effect of the talc fibers resulting in a chronic inflammatory response and increased capillary hemorrhage with subsequent calcium deposition. --Cond, from J. Am. Med. Assn. 508 Dust Exposures During Ash Removal from Incinerators. W. H. Megonnell, J. H. Ludwig, and L. Silverman. Arch, Ind. Health 15, 215-222 (Mar. 1957). Dust exposures to the operator during ash removal are not excessive for the average institutional.type incinerator, as the stack draft through the open furnace doors draws most of the dust produced by the operation back into the incinerator. Installations with small stacks, or when reverse flow is created by wind action, produce higher and more persistent dust concentrations. Incinerator operation is poorer during rainy weather. Only minor dust exposures are produced when water quenching of the ash is used, and -watting -is .ad*rta4>le~wfan -M -own beaoompK,9h'ed. AiTbtrrTO'Tdnstin^n'ctnwswr"rooms is of the same general composition as the ash. It is composed of a high percentage of small particles (50% less than 0. 5 micron), with larger particles which are predominantly ag gregates. Exposure period for operators removing ash is a function of the degree of cleaning accomplished and the quantity of ash removed. Stack draft and room ventilation appear to be the most important (actors in limiting the concentration of airborne dust in the Incinerator room. A large proportion of the dust exposure incidental to ash removal could be eliminated by careful disposal cans to take advantage of the effect of stack draft and by care in depositing ashes (rom the shovel into containers. Obviously the furnace door and grate opening should be kept open throughout all cleaning in the incinerator room. ' -- Cond. from authors' summary 509 Changes in Lungs of Experimental Animals after Intratracheal Introduction of Mineral-Wool Dust, V. A. Grimailovskaya and others. Gigiena i Sanit. ST! No, 8, 24-29 (1956). Russian. . ... Mineral.wool dust with relatively low free silica, and moderate contents of bound isilica produces in rats after 2r3 months a moderate sclerosis of diffuse and nodular types; after 5 months a peribronchial scleroses starts. This is.' caused by solubility of dust particles in the lymph. -- Chem. Absts. AFFIDAVIT OF DAVID S. EGILMAN STATE OF MASSACHUSETTS ) COUNTY OF NORFOLK ) ) ss. Before me, the undersigned authority, personally appeared Dr. David Egilman and swore as follows: 1. My name is Dr. David Egilman. I am over the age of twenty-one years old and am otherwise competent to make this affidavit. All of the statements contained in this affidavit are based upon my personal knowledge and are true and correct. 2. I am the custodian of records of the Industrial Hygiene Foundation. 3. I have personally reviewed the documents listed below, copies of which are attached to this affidavit, and can attest that the attached copies are true, complete and correct copies of Industrial Hygiene Foundation documents. Participants in Seventh Saranac Symposium with attached Affidavit dated May 21, 1991 ofMichael Rhode, employee ofthe Armed Forces Institute ofPathology, custodian of original archives ofDr. Arthur J. Vorwald, authenticating the listing. (SCF-ALLF-01290) Industrial Hygiene Digest, Industrial Health News, Literature Abstracts, Medical, Engineering, Chemical, Toxicological, Legal. January, 1950 (Vol. 14, No. 1) (SCF-ALLF-01180) Industrial Hygiene Foundation, Industrial Hygiene Digest, Industrial Health News, Literature Abstracts, Medical, Engineering, Chemical, Toxicological, Legal. September, 1952 (Vol. 16, No. 9) (SCF-ALLF-01370) Industrial Hygiene Digest, Industrial Health News, Literature Abstracts, Medical, Engineering, Chemical, Toxicological, Legal. September, 1956 (Vol. 20, No. 9) (SCF-ALLF-01760) Industrial Hygiene Foundation, Industrial Hygiene Digest. April, 1957 (Vol. 21, No. 4) (SCF-ALLF-01830) Industrial Hygiene Digest, Industrial Health News, Literature Abstracts, Medical, Engineering, Chemical, Toxicological, Legal. August, 1960 (Vol. 24, No. 8) (SCF-ALLF-02040) Page 1 of3 Industrial Hygiene Digest, Industrial Health News, Literature Abstracts, Medical, Engineering, Chemical, Toxicological, Legal. March, 1961 (Vol. 25, No. 3) (SCF-ALLF-02140) Industrial Hygiene Digest, Industrial Health News, Literature Abstracts, Medical, Engineering, Chemical, Toxicological, Legal. (SCF-ALLF-02310) Industrial Hygiene Foundation, 1967 Annual Report. (SCF-ALLF-02836) Industrial Hygiene Foundation, 1969 Annual Report. (SCF-ALLF-03082) Industrial Hygiene Foundation ofAmerica, Inc., Report ofPreliminary Dust Investigationfor Asbestos Textile Institute with attached Memorandums on Plant of (various companies) Supplementing the General Report "Preliminary Dust Investigation for Asbestos Textile Institute" ofJune, 1947. (SCF-ALLF-01000) Members ofAir Hygiene Foundation /Industrial Hygiene Foundation as ofNovember 30,1937 through 1983. (SCF-ALLF-00470) Air Hygiene Foundation ofAmerica, Inc., References to Recent Literature ofIndustrial Diseases, January 24, 1939. (SCF-ALLF-00565) Foundation Facts, Vol. 3, No. 6 with attached Digest ofIndustrial Hygiene, Literature News - Developments, datedJune, 1941. (SCF-ALLF-00685) Industrial Hygiene Digest, Industrial Health News, Literature Abstracts, Medical, Engineering, Chemical, Toxicological, Legal, Foundation Facts, August, 1957. (SCF-ALLF-01875) An Epidemiological Study ofLung Cancer in Asbestos Miners, Industrial Hygiene Foundation Report by Bruan & Truan; study made possible through a grantfrom the Quebec Asbestos Mining Association (Note: date takenfrom published article), June, 1958. (SCF-ALLF-01939) Industrial Hygiene Digest, Industrial Health News, Literature Abstracts, Medical, Engineering, Chemical, Toxicological, Legal, May, 1963, Vol. 27, No. 5. (SCF-ALLF-02375) Preliminary Program, 28th Annual Meeting, Industrial Hygiene Foundation, October 23-24, 1963, to Mr. Wagner. (SCF-ALLF-02441) Industrial Hygiene Foundation, 1964 Annual Report with attached membership list. (SCF-ALLF-02468) Industrial Hygiene Foundation ofAmerica, Inc., Asbestos Bioeffects Researchfor Industry, Medical Series, Bulletin No. 11, 1966. (SCF-ALLF-02683) Page 2 of 3 Further, affiant sayeth not. David S. Egilman, MD, MPH Commonwealth of Massachusetts Norfolk, ss SUBSCRIBED AND SWORN TO ME, on this ^ day of May, 2006, to certify which witness my hand and official seal of office. NOTARY PUBLIC IN AND FOR THE STATE OF MASSACHUSETTS My Commission Expires Vwc-------- Va \\ 1 Page 3 of 3 L