Document ge6Mva2vnbdG014vxedx3v7L

9nduM/doJ BIO - T E $ T JlaJyyiaJ/yu^, Dm. 1810 FRONTAGE ROAD NORTHBROOK, ILLINOIS 60062 23-MONTH STATUS SUMMARY TO R te. . VO RESEARCH & D_/tlOPMENT. OCT 6 1975 W. M. SMIT1' MANUFACTURING CHEMISTS ASSOCIATION CHRONIC VAPOR INHALATION TOXICITY STUDY WITH VINYL CHLORIDE (ETHYLENE DERIVED) IN ALBINO RATS, ALBINO MICE AND GOLDEN HAMSTERS SEPTEMBER 23, 1975 IBT NO. 663-03222 AP00006536 3ndu6&ucU bio - test Jkdo&zfaued', 3m. 1310 frontage road NORTHBROOK. ILLINOIS 60062 September 23, 1975 Dr. Milton Freifield Project Manager, Vinyl Chloride Research Manufacturing Chemists Association 1825 Connecticut Avenue, N. W. Washington, D. C. 20009 Dear Mr. Freifield: Ret IBT No. 663-03222 - Chronic Vapor Inhalation Toxicity Study with Vinyl Chloride (Ethylene Derived) in Albino Rats, Albino Mice and Golden Hamsters We are submitting herewith our laboratory report prepared in connection with the above study. Very truly yours, JCCrbp J. C. Calandra President AP00006537 j7B l O T S $ T lali&uitQ'u&L. 9na. ) 23-MONTH STATUS SUMMARY TO MANUFACTURING CHEMISTS ASSOCIATION CHRONIC VAPOR INHALATION TOXICITY STUDY WITH VINYL CHLORIDE (ETHYLENE DERIVED) IN ALBINO RATS, ALBINO MICE AND GOLDEN HAMSTERS SEPTEMBER 23, 1975 IBT NO. 663-03222 I. Introduction A chronic Vapor inhalation toxicity study with Vinyl Chloride (Ethylene Derived) was initiated on September 10, 1973, and termi nated on September 10, 1974. Animals were then placed on observa tion. A summary of all data obtained through the twenty-third month is reported herein. AP000065J8 3neL*iUial BIO-TEST JahoftatotiiAL, 9tc. 2 ) II. Summary Exposure of mice to Vinyl Chloride was terminated after 9 months of testing. At this time all surviving mice were placed under observation for the remainder of the investigation with the exception of the T-HI group (2,500 ppm) which was sacrificed during the eleventh month. Rats and hamsters were exposed to Vinyl Chloride for 12 months before being placed under a non-treated observation period. Respectfully submitted. INDUSTRIAL BIO-TEST LABORATORIES, INC Report prepared by: Dennis C. Lindberg, B.S. Assistant to the Manager Decatur Research Laboratories ) Report approved by: /u. ohn W. Goode, Ph.D. mager Decatur Research Laboratories Florence K. Kindshita*/Ph & Technical Manager Toxicology M . L. Keplinge^ Ph Manager, Toxicology PS AP00006539 SudnAfrUaL B I O * T E S T Snc. 3 III. Body Weight Data The mean body weight data for albino rats, albino mice and hamsters are presented in Tables I, II and III, respectively. AP00006540 AP00006541 >* 'Bn*l!BAP >"M 5 VN *<JnojS U| ilujiiniuaj |i?wiu< aMn oh = - 4 m tit 6VN S f 9 9VN m t t C C m 8tt 67 6IR lf.7 887 787 157 181 Al-J. - 9!C 4M - 6*6 iSS - os 475 * i0tIsS 666 tt* US 686 IIS 056 766 166 06 h 456 SI* 91 856 196 686i6 661 S6 166 576 676 076 if 616 Cfct S466C 6St 6t 66C 9Sf 6S 9684CE 79t E7t B9 65 Nf 99 ZM 66t tst 49591t 96f ?866C 66f 67f I7f 7IC 67t 9IE m 7 ?7t S07IHf 051I(T f ZOf. UZ 66Z 48? 687 067 767 667 717 547 5E7 591 814911 091 Ill-.l tl-A l-J. Of! |XMj V) - - 9tss M - 096 MS - - 4m64 - Ul tzi - in 86 2tS - Hi 866 tn . 184 686 C86 - IK' fL>. <,Lf. 854 *64 SZ9Si4 898944 654 694 694 694 ZU btl i0Z6L4 606 06 14 9f4 969 769 W9 679 969 t99 69 069 6S9 669 479 189 169 669 IBS 585 165 6SS 959455 496 066 495 496 666 C65 005 666 666 4(5 672755 925 415 666 066 166 66 56 656 866 9S6 ISC 091 f9691 007 107 607 soz III-J. II-.I. 1-4. yn 1* PH Ul iStixtO tz zz 17 07 61 SI 41 91 SI 61 1 71 II 01 6 s 6 9 5 6 f Z 1 0 tlncxry o (xwxjg) ipoq man IH niV * 4P"fl "N J ta .iaisiuvf| u.->p|i| pin rm|(][V '(Ir^ oufq|y _ Xpntg Xipfxnj. unfix [<>[>i| jnrlA 3JU0J1J3 s>|Xma) pijomo iAuja nviMaxvw .lrhx J ffiavi Sex Male Female Ci-oun UC T-l T-II T-ill UC r-t T-ll T-lll table u TEST MATERIAL: Vinyl Chloride (Elhylene Derived) ChrunU Vapor Inhalation Toxicity Study ' Albino Rata, Albino Mice and tad.Ua> llaumtcre Summary tA Mean Body Wtigblc ' Albino Mice Mean Body Weights (grams) Month Number} 0 1 2 3 4 i 6 7 8 9 10 11 12 13 14 15 lb 17 16 19 20 21 22 23 35 40 4i 43 4b 43 4b 52 49 47 43 47 48 47 45 4b 44 13 43 . 13 36 39 43 44 42 47 45 47 47 48 46 49 48 41 so 46 - -- --- 3b 40 J8 42 44 42 45 43 44 4b 37 44 4S 3b 38 40 43 44 38 45 41 41 43 31 24 32 33 35 3b 35 38 37 41 40 37 40 40 40 41 42 40 10 19 39 39 41 39 41 30 34 34 37 39 38 40 41 40 40 42 43 42 43 44 39 30 - -- --- 26 31 14 35 37 3b 38 3b 40 39 30 40 37 16 40 38 30 26 il 34 35 36 37 37 34 37 36 27 Oianae . - 12 - - Nu more animals roiMiiiing in group. AP00006542 I U) I Sea Male Kwnitilc Grvuii IIC T-l Til rin uc T-.l T*ll T-III taiile ni TEST MATERIAL: Vinyl Chloride (P.lhylenc Derived) Chronic Vapor Inhalation Toxicity Study * Albino Rain, Albino Mice and Col.Ion litunslcra Summary o< Mnan Body Wol|bu ' CoIiIm llMia Moan Body Weights (grams) Mwillt Number, 01 2 3 4 5 6 7 S 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 73 98 tio 120 129 no 133 no 138 141 129 126 125 131 128 126 126 I li 138 141 13) 140 143 146 71 90 101 114 120 121 122 128 126 111 115 no 115 121 124 122 125 1 12 132 136 136 137 143 150 6) 89 94 99 119 108 120 118 122 117 ns 115 121 126 131 129 130 lit 134 134 133 - - - 60 87 91 93 9) 68 112 110 116 III m 114 no 123 120 124 129 110 127 116 - ' * 77 ItM toa 118 120 121 124 129 128 133 119 116 117 115 122 119 116 J20 118 112 121 _ _ _ 78 96 102 112 118 118 122 no 126 125 118 no no 115 117 121 122 125 124 114 126 - - - 74 94 99 108 ID7 1U6 114 112 116 118 112 112 109 114 116 117 122 126 122 128 127 - - - 69 92 100 106 106 104 110 118 109 107 103 99 1I>1 105 109 112 96 -- -- - Change 73 79 - - _ - - = No mure animals remaining iu group 09 o - in i/ r i i AP00006543 Hnduibiial B l O * T E S T Ja&o^aiofiiei, 9nc. 7 IV. Mortality Data The cumulative monthly mortality data are presented in Tables IV through VI. The following is a summary of remaining animal groups: Species Sex Groups Remaining Rats Male Female UC, T-I UC, T-I Mice Female UC Hamsters Male UC, T-I From mortality data of the past 5 months of observation, the following estimations of death were obtained: Species Group and Sex Estimated Time of Death Months: Rats UC-M UC-F T-I-M T-I-F 5 5 4 1 Mice UC-F 1 Hamsters UC-M T-I-M 5 3 AP00006544 Sttdt*4&Ual B I O T E 5 T JabocaioiUei, Stic. 8 Month Number 1 2 *J> 4 5 6 7 8 9 10 11 12* 13 14 15 16 17 18 19 20 21 22 23 TABLE IV TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Summary of Mortality Data - Albino Rats Cumulative Number of Mortalities at End of Month UC T-I T--II T-HI MF MF M F M FV T-IV F 000000 000 0020 10 000 1 20 0 1 X 0 00 it 024130 140 235 1 6 1 34 0 346 1 6 1 540 448262 650 4 5 9 3 10 5 10 8 1 4 6 10 4 11 5 16 15 4 5 7 11 7 12 9 24 28 7 7 8 13 9 14 19 34 52 17 13 14 19 16 21 37 16 17 23 24 26 50 58 66 40 73 83 46 19 21 26 30 33 63 85 86 76 21 23 28 37 40 75 94 89 86 23 25 31 45 46 87 100(4) 100 100(7) 28 27 35 53 55 90 100 100 100 33 28 38 59 64 94 100 100 100 38 31 43 66 71 94 100 100 100 46 34 47 73 77 94 200 100 100 52 42 52 80 100(18) 100(4) 100 100 100 57 48 63 89 100 100 100 100 100 64 54 72 92 100 100 100 100 100 * Includes 5 males and 5 females from each group excluding T-IV sacrificed for cytogenic study, O Indicates moribund or sick animals sacrificed. ? AP00006545 Sttduihittl B I O - T E 5 T Jabtyia&yU+L, $hg. 9 TABLE V TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study * Albino Rats, Albino Mice and Golden Hamsters Summary of Mortality Data - Albino Mice Month Number UC M Cumulative Number of Mortalities at End of Month T-I T-II T-IH F MF MF M F 1 000 00000 2 00030000 3 -> 0 6 3A 1 0 1 0 4 5 1 19 5 4 1 4 7 5 8 2 26 6 4 2 8 7 6 12 2 30 6 8 3 10 9 7 18 5 31 11 9 12 13 23 8 18 5 32 14 16 30 30 46 9 23 8 38 24 37 58 56 75 10 28 10 42 31 78 82 76 98 ) 11 30 15 54 46 96 94 100 100 12 34 16 57 66 98 95 100 100 13 44 23 70 80 99 97 100 100 14 54 28 79 91 100 100 100 100 15 67 39 88 97 100 100 100 100 16 82 46 100 100 100 100 100 100 17 82 54 100 100 100 100 100 100 18 82 58 100 100 100 100 100 100 19 92 70 100 100 100 100 100 100 20 100 77 100 100 100 100 100 100 21 100 81 100 xoo 100 100 100 100 22 100 89 100 100 100 100 100 100 23 100 92 100 100 100 100 100 100 ) f AP00006546 9nd*tihial 8 I O - T E S T JafoiainiaA, Sho. 10 Month Number 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 TABLE VI TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rata, Albino Mice and Golden Hamsters Summary of Mortality Data - Golden Hamsters UC M Cumulativi5 Number of Mortalities at End of Month T-I T-n T-m F MF MF M F 5444 8 11 10 12 7525 9 16 10 11 S 13 12 14 12 18 14 13 9 15 16 16 15 19 15 13 9 18 16 16 16 20 15 15 13 18 16 16 20 21 16 16 13 28 24 19 22 33 18 26 14 28 24 19 23 35 19 28 14 29 24 20 25 36 20 28 14 30 26 20 26 37 23 29 15 31 28 21 26 38 28 36 18 36 34 33 37 46 40 45 23 40 43 49 46 49 49 58 28 46 49 58 54 53 61 69 39 61 53 72 66 55 71 84 50 78 58 83 74 59 84 100(3) 57 81 61 85 76 66 86 100 62 85 62 86 77 75 88 100 65 90 68 89 79 84 92 100 71 96 73 95 86 89 100(5) 100 71 100(2) 80 100(3) 100(13) 100(7) 100 100 73 100 82 100 100 100 100 100 78 100 85 100 100 100 100 100 () Indicates moribund or sick animals sacrificed. ) AP00006547 Jladiutual S I O ? E S T JaJ&taianUi, $hg. 11 V. Hematologic Data Twenty-three month hematologic data are presented in Tables VII through X. AP00006548 AP00006549 TABLE VII TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Male Rats Group Animal Number Total Leukocyte Count (thousands/mm-*) Test Month: 23 Erythrocyte Count (millions/mm 3) Test Month: 23 Hemoglobin Concentration (g/100 ml) Test Month: 23 Hematocrit Value <%) Test Month: 23 Untreated Control 1 4 5 7 15 17 18 19 22 27 28 34 37 40 41 42 47 49 52 53 Mean 9.0 11.3 8.7 9.8 13.6 16.0 11.5 14.8 8.0 10.8 15.6 9.7 11.6 15.0 6.6 8.8 7.9 9.2 11.6 10.4 11.0 8.03 8.89 8.97 7.30 5.30 6.91 8.52 6.40 7.79 6.57 6.14 8.17 7.88 8.19 7.84 8.55 8.44 6.65 7.84 8.70 7.65 14.2 16.0 15.6 16.1 11.5 14.6 15.7 14.8 15.2 15.4 14.8 15.2 15.6 16.2 16.0 15.9 17.0 14.0 16.0 16.2 15.3 48 53 51 50 40 48 54 46 50 50 45 48 52 52 51 50 55 44 50 52 49 ^ 'O m /t AP00006550 Group T-I TABLE VII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Male Rats Animal Number Total Leukocyte Count (thousands/mm^) Test Month: 23 Erythrocyte Count (millions/mm^) Test Month: 23 Hemoglobin Concentration (g/100 ml) Test Month: 23 Hematocrit Value (%) Test Month: 23 201 207 209 212 214 222 223 225 226 227 228 232 233 234 238 241 246 250 255 268 Mean 9.8 14.6 12.4 12.4 8.7 9.2 10.8 14.8 11.8 5.4 7.6 9.2 10.4 7.3 10.5 12.2 13.7 18.6 6.4 8.7 10.7 6.54 6.54 3.B2 7.26 6.91 6.38 6.44 6.44 7.83 6.57 7.83 7.80 8.19 8.45 7.75 9.37 6.77 7.47 6.95 7.18 7.12 12.4 14.0 8.6 14.4 14.3 13.7 13.8 10.4 15.2 13.7 15.2 14.3 15.8 15.6 15.4 16.4 13.6 14.0 13.8 14.6 14.0 40 44 30 46 44 42 46 38 49 42 47 44 50 49 48 52 41 45 42 44 44 nt / r AP00006551 TABLE VIII TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Female Rats Group Animal Number Total Leukocyte Count (thousands/mm *) Test Month: 23 Erythrocyte Count (millions/mm^) Test Month: 23 Hemoglobin Concentration (g/100 ml) Test Month: 23 Hematocrit Value (%) Test Month: 23 Untreated Control 102 105 107 108 111 112 113 117 118 119 121 123 124 125 127 130 131 132 133 134 Mean 13.0 9.1 7.8 15.3 8.3 15.6 10.3 3.6 6.1 11.1 9.0 14.4 10.8 6.1 5.8 20.0 5.0 5.9 8.1 7.0 9.6 5.02 6.78 6.38 7.15 5.29 4.49 5.49 7.26 5.80 5.43 6.10 4.90 6.25 7.27 7.10 2.69 7.18 7.60 6.54 7.30 6.10 12.0 14.9 13.2 14.6 10.4 9.1 12.2 14.6 12.0 12.2 13.6 10.0 13.2 14.8 14.0 5.7 14.6 14.4 13.5 14.4 12.7 40 48 42 46 34 30 38 46 38 38 42 35 40 46 43 22 46 45 42 45 40 CO o m i/i BIO -TEST A AP00006552 Group T-I TABLE VIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Female Rats Animal Number Total Leukocyte Count (thousands/mm^) Test Month: 23 Erythrocyte Count (millions/mm^) Test Month: 23 Hemoglobin Concentration (g/100 ml) Test Month: 23 Hematocrit Value <%) Test Month: 23 315 322 326 337 352 354 363 Mean 9.6 a.4 24.6 9.0 28.4 14.9 5.9 14.4 7.11 6.95 2.01 8.24 6.28 4.42 8.60 6.23 13.2 13.6' 4.4 13.8 10.8 8.8 13.5 11.2 43 43 17 49 36 30 46 38 U) 9ttdufrtial 3 I O T S S T JaliMatotiti, jW u x x| Q, XZ rro1 (9 X in fl ho to 9 X o X ao 2Z <r"-j1 O rH o 82 c 3 X X (S g *e(09 4> 0. oh V 1 TEST MATERIAL: V in yl C hloride (Ethylene D erived) gzS *<5 ** - OS S* -s oG 2 (9 as 2 <9 s 0c & a < 1 >> TJ t4o3-> oX E-i co a<4 1X3 _c 0l* 0. 3 <9 Q o60 B (9 u as Xa XooN 3o X a (a9 0u0c1 a 2c41 CuO to 4gJ X x a0 2 301 Z I* <9 Z *X 4-> OS <9 > S o* Xcou CD C OS o eo (uns> m co Si--t' lr/ol vo Or-' mrt Svh Sx 5e S3 *Z o*1* 8 4- (-H rj o h 5c So DO UrSj 4U) 3 CD O a 41 Cfl % 4-> 41 & * Xa0 34> c B 2cf1 io u X (U9 41 > 41 to 16 AP00006553 Group Animal Number Untreated Control 106 112 117 130 T-I 326 352 354 TABLE X TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Female Rats Ring* Differential Leukocyte Count (number of cells per hundred) Neutrophils Band Segmented Lymphocytes Monocytes Eosinophils Month Number: Month Number: Month Number: Month Number: 23 23 23 23 Basophils Month Number: 23 71 34 52 5 1 0 14 0 52 31 1 2 0 70 30 63 .0 0 0 11 1 34 54 0 0 0 n0 35 53 1 0 0 13 0 31 54 1 1 0 90 32 57 2 0 0 * Several of the ring-form neutrophils were twisted like a figure 8. SnduibUol B I O - T E S T aiiytai&Ue&t Sue. 18 VI. Gross Pathology Tables XI, XII and XIII present suspected treatment-related tumors based on lessions found during gross necropsy. These lessions will be evaluated by histopathological examination to determine their true value. Tumor Key C ESC P PMA S A = cannibalized ~ escaped = postmortem animal valid evaluation precluded by postmortem autolysis = sacrificed animal = sacrificed in^ extremis = animal still alive ? AP00006555 Httdu&Uial B 1 O * T H S T Jtaii&mi&ii&i., 0*t&. 19 TABLE XI TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Test Untreated 1 Control 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 557 530 372 411 504 556 564 532 590 331 656 681 712 609 607 424 645 712 611 402 138 365 146 612 Mortality Data Liver Spleen Lune A P P A A P A P PMA P PMA PMA PMA P A P A A A P P A P P P SE A A P PMA P P PMA A PMA PMA Skin Misc. X X X X X Kidney AP00006556 3*uiudlUal B I O T E S T 2a&MafM4eA, Sha. 20 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Tojdcity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated 37 Control 38 continued 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 A 660 P 360 S X A A A 667 SE 702 PMA 524 PMA 619 P A 703 P A 673 P 204 P A A 360 S 360 S 692 P A X 641 P 347 PMA 463 PMA 272 P A 456 P A 572 P 581 P 511 P A 360 S X 626 P 578 PMA A X X Kidney X X X r AP00006557 HttduAt'Ual BIO-TEST ah>\ai&U*i, 3**o. 21 TABLE XI continued ) TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats. Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Mortality TeatData Liver Spleen Lung Skin Misc. Untreated 73 A Control 74 599 P continued 75 541 P 76 305 PMA 77 675 P X 78 A 79 A 60 A 81 A 82 685 P ) 83 603 P 84 360 S XX 85 699 P 86 595 P 87 587 P 88 713 PMA 89 384 P 90 302 P 91 706 PMA 92 507 P 93 415 P 94 409 P 95 384 P 96 591 P X 97 168 P 98 474 P 99 496 P 100 710 P X X X X f T AP00006558 StidmUiaL BIO-TEST JabotaioMel, 9nc* 22 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc 201 A 202 462 P 203 146 PMA 204 668 P 205 361 S X 206 642 P 207 A 208 701 PMA 209 A 210 536 P 211 189 P 212 A 213 703 P X 214 A 215 145 P 216 568 P 217 599 P X X 218 718 P 219 529 P 220 101 PMA 221 541 P 222 A 223 721. P 224 666 P X 225 A 226 A 227 A 228 A 229 675 P 230 74 PMA 231 719 P X 232 A 233 A 234 A 235 324 PMA 236 645 P X X X I AP00006559 3>uL*i&dal B I O - T E 5 T Ja&vtafa*/**, 3m. 23 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Test T-I 237 continued 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 136 646 261 722 693 669 611 595 695 703 526 508 113 693 361 634 34 5B1 617 624 275 274 361 693 318 662 642 270 99 271 534 272 640 Mortality Data Livei PMA A P ? P P PMA P P A P P P A A P P P A S PMA PMA P P P PMA P S P P P A P X X X X X X X X C P P X Skin Mis c. Thymus Kidney X X Kidney X Kidney X Kidney AP06606560 SndniUiaL B I 0 - T E S T 9*ta. 24 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Days Animal on Mortality Group Number Te9tData Liver Spleen Lung T-I 273 690 P continued 274 661 SE 275 504 P 276 158 PMA 277 388 P 278 569 P 279 361 S 280 383 P 281 585 P X 282 A 283 204 P 284 670 P X 285 A 286 665 SE X 287 547 PMA 288 531 P 289 43 ESC 290 438 P 291 412 ESC 292 A 293 541 P 294 573 P 295 224 P 296 89 PMA 297 94 PMA 298 249 PMA 299 361 S X 300 547 P Skin Misc, X X X AP00006561 ^ndtuifUat B l O - T E S 7 JaioMaionU^, Hhc. 25 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin 401 495 P X 402 505 P 403 626 p X 404 3bl S X 405 474 P X 406 534 P X 407 527 SE X 408 555 P 409 535 P 410 340 PMA 411 485 PMA 412 631 S X 413 631 S X 414 506 P X 415 64 P 416 597 P X 417 506 P X 418 631 s X 419 574 p X 420 415 p 421 604 p X X 422 449 PMA 423 108 PMA 424 341 P X 425 589 P 426 626 S X 427 529 PMA 428 626 S X 429 611 P X 430 626 s 431 297 p X 432 317 PMA 433 361 S X 434 617 P X 435 626 S X 436 626 s X X v X X X X X Misc. Pancreas Mesentery Thymus AP00006562 Sttduij/iial BIO-TEST JlaltatatoMai, 9hc. 26 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number T-II 437 continued 438 439 440 441 442 443 444 445 446 447 448 449 450 45L 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 Days on Test 478 381 474 626 134 616 451 535 626 576 449 482 501 507 532 626 626 502 452 626 466 526 361 577 333 575 485 626 465 239 547 395 361 224 626 244 Mortality Data Live P P PMA S PMA PMA P PMA S P P P P P PMA S s PMA P S P PMA S PMA P PMA PMA S P PMA P P S P s p X X X X X X X X X X X X X X X X X Skin X X Misc. AP00006563 J}+uh*d&tial BIO-TEST fnL\Ji^nt,)oA 27 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc. T-H 473 502 P continued 474 544 P 475 626 g 476 229 P X X X 477 374 P X 47S 196 PMA 479 590 PMA 480 231 PMA 481 525 P 482 569 P X X 483 596 P 484 626 S X 485 468 P 486 513 P X 487 223 PMA 488 223 PMA 489 361 S X 490 359 PMA 491 626 S 492 432 P 493 465 P 494 612 P X X 495 536 PMA 496 480 P X 497 446 P 498 429 P 499 129 P 500 480 P X X X Prostate Seminal vesic! X X X X Lymph nodes i AP00006564 ^nduii'Uai B I O - T S S T Httc. 28 TABLE XI continued I TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc, T-III 601 355 SE 602 247 PMA 603 272 p 604 402 P X X 605 366 P X 606 242 P 607 344 P X 608 384 P X X 609 361 S 610 439 P X ) 611 390 P XX 612 236 P Mesentery 613 394 P X 614 400 P X 615 411 P X 616 496 P 617 250 P 618 498 s X X 619 426 P X 620 470 P X 621 371 p X X 622 244 p X 623 292 p X 624 362 SE X X 625 341 SE X XX 626 344 P X 627 353 P X 628 448 P X 629 389 P X 630 424 P 631 452 PMA X X 632 341 SE X > 633 341 P 634 455 P X X X 635 177 P 636 392 P X AP00006565 9*tJ*uinicd B t O * T E S T ^ahviat&U&i, 9na. 29 TABLE XI continued ) TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Test Mortality Data Liver T-m 637 405 P continued 638 412 P X 639 361 S X 640 459 P X 641 359 SE 642 208 PMA 643 293 P X 644 498 S X 645 340 P X 646 373 P ) 647 258 P 648 314 P 649 402 SE 650 318 PMA 651 372 SE X 652 386 P X 653 281 P 654 452 P 655 343 SE 656 428 P X 657 148 P 658 427 PMA 659 453 P X 660 92 P 661 299 P X 662 339 P X 663 361 S X 664 373 SE 665 274 P 666 382 P X 667 383 SE X 668 361 S X 669 377 P X I 670 366 P X 671 383 SE X 672 310 SE Lung Skin Misc. X Kidney X X Brain Brain X Brain AP6db06566 DHdudUial 8 I O - T E S T Ja/*yiayu&i, 9h& 30 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Test Mortality Data Liver Skin T-UI 673 continued 674 675 676 677 678 679 680 681 682 683 684 685 686 687 688 689 690 691 692 693 694 695 696 697 698 699 700 321 P XX 335 PMA 352 SE 342 P X 297 SE 304 P 428 P X 273 PMA 314 P X 296 SE X 338 P 359 P X X 374 P X 360 P X 498 S X 443 P X 308 P X 393 PMA 413 P X 408 P 157 PMA 361 S X 455 P X 311 P 364 P X 383 P 332 P X X 143 P Misc, AP00006567 $Hdu4&Xal B J O - T E 5 T Jaiwai&tf&u 2hc. 31 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test Mortality Data Liver Spleen Lunc Skin Untreated 101 Control 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 661 713 649 360 513 704 573 673 386 619 575 563 313 557 492 SE A ? P A S A A PMA P A A A P P SE A A A p A P A A A PMA A P P A A A A A PMA A X X X X X X X X X X AP00006568 3ttd*4&i'Ual B I O - T E $ T ^ahotetityUeA, Jno. 32 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats i Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test Mortality Data Liver Spleen Lurie Skin Untreated 137 A Control 138 504 P continued 139 460 P X 140 A 141 612 P 142 A 143 A 144 619 P 145 718 P 146 A 147 452 P 148 A 149 360 S X 150 A 151 113 P 152 715 P 153 A 154 71 P 155 704 P 156 656 P 157 596 P 158 A 159 652 SE 160 360 S 161 357 P 162 691 PMA 163 616 P 164 499 P 165 544 P 166 A 167 129 PMA 168 607 PMA 169 296 P 170 698 P 171 272 PMA 172 A X X X X X X X X X ? AP00006569 Dndud&Ual BIO-TEST ^a&oAnto.tJt, $na. 33 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test Untreated 173 Control 174 continued 175 176 177 178 179 180 181 182 183 184 169 222 611 361 640 660 665 185 616 186 669 187 188 614 189 631 190 199 191 192 241 193 461 194 596 195 196 197 495 198 699 199 531 200 361 Mortality Data Liver Spleen Luns P A ? A P SX P A PX A A SE P P A P P PMA A PMA PMA SE A A SE P P S X Skin X X X X X X X Misc. Adrenal gland Adrenal gland Adrenal gland -} ! AP00006570 Swtuiinial B I O T E 5 T JlahyiaiyUet., Snc. 34 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Grouo Number T-I 301 302 Days on Test 460 652 Mortality Data Liver Soleen Lung PX SE Skin 303 304 305 306 307 308 309 310 311 312 313 314 315 326 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 ' 361 604 569 174 479 238 651 512 555 595 404 516 283 630 247 41 388 460 641 691 522 718 616 451 614 413 661 617 621 577 656 S P P PMA PMA P P P P P P P A P P P PMA P P A P PMA P SE P P P P SE P P P SE V X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Misc. Adrenal gla Adrenal gl; 1 AP00006571 9ttdbuibaaL BI O T E S T ^ttc. 35 ) TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test Mortality Data Liver Soleen Lung Skin Misc. T-I 336 524 P continued 337 A 338 4?7 P Vk 339 607 P X 340 632 P 341 180 PMA 342 214 P 343 588 P 344 760 PMA 345 573 P X 346 180 PMA 347 116 PMA 348 427 P 349 361 S X 350 466 P 351 597 P 352 A 353 300 P 354 A 355 540 P 356 449 PMA 357 449 P X 358 531 P 359 49 PMA 360 51 PMA 361 547 PMA 362 493 P 363 A 364 333 PMA 365 454 PMA 366 476 P 367 523 P 368 428 P 369 361 S X 370 521 PMA 371 277 P 372 437 P X X X y_ X X X X X X X XX X X X X Kidney X I AP00006572 Sndusinici B 1 O T E S T jaJtonaio*U&, 9tt&. 36 TABLE XI continued TEST MATERIAL: Vinyl Chloride CEthylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test T-I 373 continued 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 390 391 392 393 394 395 396 397 398 399 400 CO C"l 84 536 542 642 381 198 494 419 361 656 513 519 337 356 654 400 283 584 127 556 387 576 593 346 361 703 532 591 Mortality Data Liver Spleen Lun PX P P SE P PMA P PMA S SE P P P PMA P PMA P PMA PMA PMA PMA P P PMA S P P P- X X X X X X X X X Skin V X X X X X X X X X X X X Misc. Kidney Uterus Adrenal gl< r AP00006573 fadu&tnial B ! O - T E S T Jafotafotied, $tte. 37 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Group Animal Number Days on Test T-II 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 518 519 520 521 522 523 524 525 526 527 528 529 530 531 532 533 534 535 536 537 473 341 471 483 384 360 438 433 327 395 626 348 295 624 377 377 515 208 356 360 143 626 480 361 466 392 364 471 515 420 488 414 389 437 238 509 508 Mortality Data Liver Spleen Lune PMA P P P P P P PMA PMA PMA SE P PMA P P P P P P SE P S P s PMA P P PMA PMA P P P P P PMA P P X X X X X X X X X X X X X X X X X X X X X X X Skin X X X X X X X X X X X X Misc. Kidney Mesentery AP00006574 Dndudt'ual BIO-TEST 2aky\atorte&, Jnc. 38 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test T-H 538 continued 539 540 541 542 543 544 545 546 547 548 549 550 551 552 553 554 555 556 557 558 559 560 561 562 563 564 565 566 567 568 569 570 571 572 573 377 316 359 341 281 306 356 487 428 373 396 303 361 336 335 427 500 461 399 626 496 393 321 314 222 314 452 402 626 366 429 361 443 417 363 416 Mortality Data Liver Spleen Lune PMA PMA PMA P P P P P P P P P S PMA P P P PMA P S PMA P P P P P P P S P P s p p p p X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Skin X X X X X X Misc. Pancreas Thymus Kidney Adrenal glan AP60066575 Sndtuitial B I O T S S T Ja6o*aiytf6i, 9nc. 39 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Groun Animal Number Days on Test T-H 574 continued 575 576 577 578 579 580 581 582 583 584 585 586 587 588 589 590 591 592 593 594 595 596 597 598 599 600 276 325 379 345 468 234 262 395 411 309 505 306 429 420 419 402 311 311 388 387 361 357 429 417 454 361 335 Mortality Data Liver Soleen Lune P P P PMA P P PMA P P P P P P P P P PMA P PMA PMA S PMA P PMA P S PMA X X X X X X X X X X X X X X X X X X X X X X X Skin X X X Misc. Lymph nodes AP00006576 ^hcLu&UoI B 1 O T E 5 T Jaipiafoue*, One. 40 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Mortality Test________ Data Liver Spleen Lung Skin 701 366 P X 702 262 P 703 185 c 704 373 PMA 705 443 P 706 373 P 707 346 P X X 708 375 PMA 709 306 SE X 710 240 P 711 333 P X 712 303 PMA 713 261 P X 714 405 P X 715 312 P X 716 353 P X 717 361 S X 718 383 P X 719 405 P X 720 224 P X 721 211 P 722 317 SE 723 374 P X X 724 296 P X 725 438 P X 726 321 P 727 303 P 728 361 S X 729 381 P 730 443 P X 731 319 PMA 732 361 S 733 334 SE X 734 82 PMA 735 361 S X 736 316 PMA X X X X X Misc. Thymus Salivary gland AP00006577 Owhu&ual BIO-TEST Jo6&iafoUe&, One. 41 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-III 737 378 PMA continued 738 295 P 73? ?/'* T5 X x 740 362 SE X 741 311 P 742 361 S X 743 325 PMA 744 367 P X 745 351 PMA 746 368 SE X 747 235 P X 748 347 P X 749 379 P X 750 336 P X 751 82 PMA 752 82 PMA 753 377 P X 754 371 P X 755 277 P X 756 348 P X 757 374 P X 758 383 PMA 759 62 PMA 760 320 P X 761 354 SE X 762 256 P X 763 365 P X 764 290 P X 765 322 P 766 311 SE 767 326 5E X 768 311 P X 769 113 PMA 770 268 P X 771 286 P X 772 330 P X X X X X X X X X Misc. Pancreas Thymus Kidney AP0bb06578 y*uLtfrUal B 1 O - T E S T jjai&iai&tfei, 9mc. 42 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test T-III 773 continued 774 77S 776 777 778 779 780 781 782 783 314 343 339 284 365 299 325 353 389 322 303 Mortality Data Liver Spleen Lung P P p P P C PMA SE P P SE X X X X X X X Skin X . 784 372 PMA 785 283 P X 786 113 PMA 787 113 PMA 788 113 PMA 789 324 P X 790 113 PMA 791 401 P X 792 339 P X 793 274 P X 794 271 P X 795 113 PMA 796 78 ESC 797 78 ESC 798 346 P X 799 78 ESC 800 78 ESC X X Misc. Salivary gland Cervical lymph nodes Kidney AP00006579 SHduAbUetl BIO-TSST a&o*a&vUe&, ftte* 43 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-IV 2401 2402 2403 2404 2405 2406 2407 2408 2409 2410 2411 2412 2413 2414 2415 2416 2417 2418 2419 2420 2421 2422 2423 2424 2425 2426 2427 2428 2429 2430 2431 2432 2433 2434 2435 2436 379 359 31*. 345 411 405 310 398 434 268 473 349 434 496 261 498 346 351 352 398 498 342 379 434 498 489 457 366 382 297 372 429 311 264 342 484 P PMA PMA P P P PMA P P P P P SE P PMA S P P P P 5 PMA PMA P S P P P P P PMA P P P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Misc. Mesentary Pancreas AP00006580 jndu&t'ual B I O - T E S T JafatataM9*c. 44 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats i Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number T-IV 2437 continued 2438 Days on Mortality Test________ Data Liver Spleen Lung 385 P 306 SE X Skin 2439 2440 2441 2442 2443 2444 2445 2446 2447 2448 2449 2450 2451 2452 2453 2454 2455 2456 2457 2458 2459 2460 2461 2462 2463 2464 2465 2466 2467 2468 2469 2470 2471 2472 365 394 306 381 473 352 385 385 340 325 370 426 426 365 331 423 220 330 392 375 387 365 498 326 375 318 411 356 365 432 424 361 383 414 P PMA P P P P PMA P P P P PMA P PMA PMA P PMA PMA P P P PMA S SE P PMA P P PMA P P P PMA P X X X X X X X X X X X X X X X X X X X X X X X X X X Misc. Cervical lymph nodes Lymph nodes AP00006581 QttMuUlal BIO-TEST Jta&o*atoA4e&, 9hc* 45 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Mortality Test________ Data Liver Spleen Lung Skin T-TV 2473 continued 2474 2475 2476 2477 2478 2479 2480 2481 2482 2483 2484 2485 2486 2487 2488 2489 2490 2491 2492 2493 2494 2495 2496 2497 2498 2499 2500 447 431 351 448 469 368 407 417 323 398 316 314 250 348 476 440 344 403 390 379 415 498 355 368 356 285 422 432 PX PX X X P XX PX PX PMA PMA PX PMA P P PMA X X SE X P PX PX X PMA P X PMA PMA PMA S P PMA X X PMA SE X P PX X Misc. Pancreas Mesentery Ovary Kidney Mesentery AP00006582 StuLii&ial B J O - T E S 7 JaAa^aio^s, 46 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rate, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Untreated Control 801 802 803 8Q4 805 806 807 808 809 810 811 812 813 814 815 816 817 818 819 820 821 822 823 824 825 826 827 828 829 830 831 832 833 834 835 560 429 569 174 428 371 301 429 502 329 452 204 428 197 190 388 505 148 305 474 568 187 94 568 134 418 122 134 321 340 200 570 462 401 94 PMA PMA PMA PMA PMA PMA P P P P P PMA PMA PMA P P PMA PMA P PMA P P P P PMA PMA PMA PMA P PMA PMA PMA P P P Misc. r AP00006583 HnduAitUal 8 I O - 7 E 5 T jfoe. 47 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Untreated Control continued 836 837 338 839 840 841 842 843 844 845 846 847 848 849 850 851 852 853 854 855 856 857 858 859 860 861 862 863 864 865 866 867 868 869 870 116 178 503 416 388 279 302 213 390 451 390 575 461 271 527 497 441 161 255 255 261 174 564 148 178 178 435 496 272 376 409 564 454 351 349 Mortality Data Liver Spleen Lune PMA P PMA PMA PMA PMA PMA PMA P PMA P P PMA SE PMA P P PMA PMA PMA P PMA PMA P P PMA PMA P PMA P P PMA P SE P X Skin Misc. Kidney ? AP00006584 UnduAhial B I O - T E 5 7 Ja&QttaioAiet, 9*tc, 48 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Untreated Control continued 871 872 873 874 875 876 877 878 879 880 881 882 883 884 885 886 887 888 889 890 891 892 893 894 895 896 897 898 899 900 176 567 150 276 152 466 450 371 500 411 431 423 406 380 381 459 292 376 431 275 316 530 94 409 378 262 428 354 277 424 Mortality Data Liver Spleen Lung P PMA PMA P PMA P P PMA P P P PMA P P P P P P P PMA P P PMA P P PMA P P PMA PMA Skin Misc. AP00006585 Sttdu&i/Ual B I O - T E S T One. 49 f TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-I 1001 149 P 1002 445 P 1003 392 PMA 1004 362 P 1005 492 P 1006 421 P 1007 130 C 1008 309 PMA 1009 498 S ) 1010 1011 332 79 PMA C 1012 79 PMA 1013 85 C 1014 65 c 1015 85 c 1016 309 p 1017 378 p 1018 136 c 1019 1020 92 290 c p 1021 121 c 1022 437 p 1023 121 c 1024 1025 498 498 s s 1026 367 PMA 1027 1028 413 137 P P 1029 332 PMA 1030 498 S 1031 115 P 1032 346 P 1033 115 P 1034 1035 173 281 PMA P Prostate X X Mesentery X X X Mesenteric nodes X AP00006586 SMduiifUaL BIO-TEST fv 9uc. 50 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Days on Mortality Group Number TestData Liver Spleen Lung Skin Mtsc. T-I 1036 continued 1037 1038 1039 1040 1041 1042 1043 1044 1045 1046 1047 1048 1049 1050 1051 1052 1053 1054 1055 1056 1057 1058 1059 1060 1061 1062 1063 1064 1065 1066 1067 1068 1069 1070 407 150 373 196 265 205 275 377 378 123 145 247 149 498 243 389 121 196 118 196 149 145 85 121 346 165 271 121 104 498 121 332 286 434 121 P PMA P. P P PMA PMA P P PMA PMA P P S PMA P P P PMA P P PMA C C P PMA PMA C PMA S P P P P c X X Mesenteric nodes X X X X X X AP06606587 fadmhial BtO-TEST JakviatMted* 9hc. 51 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test T-I 1071 continued 1072 1073 1074 1075 1076 1077 1076 1079 1080 1081 1082 1083 1084 1085 1086 1087 1088 1089 1090 1091 1092 1093 1094 1095 1096 1097 1098 1099 1100 446 316 294 377 386 366 401 311 319 437 406 362 448 498 432 406 407 407 275 410 267 332 360 293 369 432 386 353 446 365 Mortality Data Liver Spleen Lunj P PMA PMA PMA P P P P P P P P PMA S P PMA P P P PMA P P P PMA P P P P P P X X X X X X X X X X X X X X X Skin Misc. Mesenteric nodes Kidney Kidney r AP00006588 SududMal B 1 O T E S T JaA&iat&Uas, Shc. 52 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rate, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin_______ Mlsc. 1201 320 P X X 1202 277 P X X Kidne" 1203 FX 1204 225 P X 1205 274 P X X Mesentery 1206 296 P X X 1207 1208 254 291 P P X X X 1209 275 P X X 1210 1211 309 286 P P X X X 1212 331 SE X X 1213 351 P X X 1214 1215 331 322 SE PMA X X 1216 359 P X X Mesenteric nc 1217 293 P X X 1218 318 SE X X 1219 1220 272 291 P PMA X X 1221 226 P X 1222 285 P X X Kidney 1223 291 P X 1224 225 P X 122 5 269 P X 1226 374 P X X Lymph nodes 1227 299 PMA 1228 295 PMA 1229 284 P X X 1230 310 P X 1231 276 P X X 1232 311 SE X 1233 1234 290 297 P P X X X 1235 308 P X AP00006589 SnctudiMal B I O - T E 5 T sfotafouei, fttc. 53 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats* Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Spleen Luns T-n 1236 continued 1237 1238 1239 1240 1241 1242 1243 1244 1245 1246 1247 1248 1249 1250 1251 1252 1253 1254 1255 1256 1257 1258 1259 1260 1261 1262 1263 1264 1265 1266 1267 1268 1269 1270 348 P 340 P 317 P 268 P 292 P 143 P 368 P 303 P 302 " P 310 P 389 P 268 P 288 PMA 300 PMA 340 P 290 P 258 P 258 PMA 271 P 282 P 264 P 401 P 292 P 303 P 304 PMA 287 P 313 P 383 P 244 P 299 PMA 276 P 249 PMA 180 P 302 P 303 P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Skin Misc. Kidney Mesenteric nodes AP00006590 Hndu&bUal B l O - T E S T a6onato*i*&, 3**c. 54 ) TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. i T-H 1271 continued 1272 283 258 P PMA X 1273 339 P X 1274 324 P X 1275 317 P X 1276 216 P X 1277 261 P X 1278 273 PMA 1279 288 P X ) 1280 1281 288 265 PMA PMA 1282 289 P X 1283 289 P X 1284 286 P X 1285 145 PMA 1286 277 P X 1287 1288 248 284 P P X X 1289 197 P X 1290 305 P X 1291 91 ESC 1292 91 ESC 1293 255 P X 1294 306 P X 1295 253 P X 1296 214 SE 1297 298 PMA 1298 234 P X 1299 294 PMA 1300 294 P X X X X X X Lymph nodes X X xX x X x Kidney i X x X Salivary glands X X AP00006591 9nthi&bilal BIO-TEST Jafotafotfei, 9hg> 55 ) TABLE XU continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Group T-III Animal Number 1401 1402 1403 1404 1405 1406 1407 1408 1409 1410 1411 1412 1413 1414 1415 1416 1417 1418 1419 1420 1421 1422 1423 1424 1425 1426 1427 1428 1429 1430 1431 1432 1433 1434 1435 Days on Test 143 248 276 264 169 93 219 130 208 306 304 312 277 312 221 273 248 280 255 239 237 274 288 220 245 234 274 236 282 127 290 211 291 235 254 Mortality Data Liver Spleen Luna PMA P P P P C SE PMA P P P S PMA S PMA P SE P P P P P P P P P P P P PMA P P P P SE X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Skin Misc. Mesentery AP00006592 S^duAifUal B 1 O - T E S T JtaJxnaltvUe&, Stic. 56 TABLE XII continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Spleen Luns T-IH 1436 continued 1437 1438 1439 1440 1441 1442 1443 1444 1445 1446 1447 1448 1449 1450 1451 1452 1453 1454 1455 1456 1457 1458 1459 1460 1461 1462 1463 1464 1465 1466 1467 1468 1469 1470 257 121 310 312 258 179 220 121 254 288 287 230 165 108 144 278 311 252 290 295 254 311 267 241 215 258 252 248 274 312 302 255 281 310 277 P PMA SE S P PMA PMA PMA P P P P PMA PMA PMA P P PMA PMA P PMA P SE P PMA PMA PMA PMA P S P P P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Misc. Kidney Mesentery Kidney AP00006593 SncUtdirtfal B I O - T E S T Ja&taivU*&, 9*tc. 57 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-ni 1471 continued 1472 1473 1474 1475 1476 1477 1478 1479 1480 1481 1482 1483 1484 1485 1486 243 240 241 263 260 302 265 198 226 250 260 287 283 231 224 312 PMA P P P PMA PMA PMA PMA PMA P PMA PMA P PMA PMA S X X X X X X X X X X X X 1487 1488 1489 1490 1491 1492 1493 1494 1495 1496 1497 1498 1499 1500 266 276 236 229 148 230 306 194 241 312 325 262 221 224 PMA P PMA P PMA PMA PMA P PMA S PMA P P PMA X X X X X X X X X XX Misc. Mesentery Cervix F AP00006594 SndiU&Ual B I O T E S T jtab&iai&uAi, SB ) TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc, Untreated 901 Control 902 903 904 905 906 907 908 909 910 911 912 913 `914 915 916 917 918 919 920 921 922 923 924 925 926 927 928 929 930 931 932 933 934 935 428 308 345 266 266 390 522 511 511 641 564 616 435 313 564 405 664 325 508 392 571 364 202 579 702 647 511 665 547 669 367 392 511 PMA P P P P PMA P P PMA PMA A PMA P PMA PMA PMA PMA PMA PMA PMA P P PMA PMA PMA PMA PMA P P PMA P SE PMA A PMA AP00006595 $Htlu&bUal BlO *T E ST Ja&viafoUeS, !)ttc. 59 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated Control continued 936 937 933 939 940 941 942 943 944 945 946 947 948 949 950 951 952 953 954 955 956 957 958 959 960 961 962 963 964 965 966 967 968 969 970 99 209 427 271 582 326 492 511 374 572 511 666 579 709 321 471 440 423 579 551 432 209 371 315 486 672 578 714 450 574 322 575 P PMA P P PMA P P PMA P PMA PMA P PMA A. PMA PMA A P SE A P PMA PMA P PMA P P PMA PMA P PMA P P PMA P AP00006596 BIO-TE$T $ho. 60 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated 971 Control 972 continued 973 974 975 976 977 978 979 980 981 982 983 984 985 986 987 988 989 990 991 992 993 994 995 996 997 998 999 1000 569 449 500 506 526 408 416 526 300 572 405 374 434 500 579 372 667 504 573 452 522 429 94 547 598 666 662 577 439 467 P P PMA P PMA PMA PMA PMA P PMA PMA P PMA PMA P PMA PMA P PMA P PMA P P P PMA P PMA PMA PMA P AP00006597 J/ndtidiiial BIO-TEST $ttc. 61 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Group Animal Number Days on Test Mortality Data Liver Spleen Luna Skin T-I 1101 1102 1103 1104 1105 1106 1107 1108 1109 1110 1111 1112 1113 1114 1115 1116 1117 1118 1119 1120 1121 1122 1123 1124 1125 1126 1127 1128 1129 1130 1131 1132 1133 1134 1135 271 435 375 307 338 329 380 359 316 192 354 498 414 368 377 402 264 262 196 374 343 423 323 333 396 249 349 354 462 308 416 329 360 85 382 PMA P P P SE PMA P P P P P s p p p p PMA SE P P P P P P PMA PMA P P P PMA PMA P P C P X X fc X X X X X X X XX X XX XX X XX XX XX X X X X X X X X X X XX X Misc. Mesentery Kidney Kidney Mesenteric nc Kidney Kidney Uterus Kidney AP00006598 Utidudbiial B ! O T E 5 T Jalwiai&tteL, Hh& 62 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Group Animal Number 1136 1137 1138 1139 1140 1141 1142 1143 1144 1145 1146 1147 1148 1149 1150 1151 1152 1153 1154 Days on Test 325 246 187 232 353 340 444 351 236 370 309 398 450 356 429 380 54 388 353 1155 1156 1157 1158 1159 1160 1161 1162 1163 1164 1165 1166 1167 1168 1169 1170 388 260 388 382 294 309 416 416 253 320 347 373 283 380 449 55 Mortality Data Liver P PMA P PMA P SE P P P P P P PMA P P P C P P X X X X X X X Spleen X Lung X X X X X PMA SE P P P P PMA PMA P P PMA P P P PMA C X X X X X X Skin X Misc. X X Mesenteric nodes Mesenteric nodes Mesentery X Mesentery X X X Mesentery Mesenteric nodes Kidney X Kidney X Stomach X X Mesenteric nodes AP00006599 9nchi6&Ual BIO-TEST Jtalwat&tf&L, Una. 63 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Spleen Luna Skin Misc. T-I 1171 continued 1172 1173 1174 1175 1176 1177 1178 1179 1180 1181 1182 1183 1184 1185 1186 1187 1188 1189 1190 1191 1192 1193 1194 1195 1196 1197 1198 1199 1200 55 304 416 355 319 218 428 341 320 341 29D 342 295 397 373 284 295 355 343 339 261 305 308 309 247 323 416 123 498 202 C SE PMA P P PMA P P P P P P P P P PMA P PMA PMA P PMA PMA P P P P PMA PMA P X X X X X XX XX XX X Ovary X Uterus X X Kidney XX X X Kidney X Kidney, Cervix X XX Uterus XX X Mesenteric nod Kidney XX APbbbo66o6 Snctudfotal B I O - T E S T aityUeS, 9ne. 64 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Group T-U Animal Number 1301 1302 1303 1304 1305 1306 1307 1308 1309 1310 1311 1312 1313 1314 1315 1316 1317 1318 1319 1320 1321 1322 1323 1324 1325 1326 1327 1328 1329 1330 1331 1332 1333 1334 1335 Days on Test 95 259 258 240 290 226 228 296 190 265 231 327 373 214 270 257 278 270 255 333 236 237 316 278 275 277 230 250 218 276 299 222 258 278 278 Mortality Data Liver Spleen Lung P P P P P P P P P P P PMA P PMA PMA P P P P P P P P P P P PMA P P P P P P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Skin Misc. X X X X Lymph nodes X Mesenteric nodes AP00006601 $rtduA&Ual B I O T E S T Ja&Mai&tUd, Unc. 65 TABLE XII continued TEST MATERIAL: Vinyl CHloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test T-H 1336 continued 1337 1333 1339 1340 1341 1342 1343 1344 1345 1346 1347 1348 1349 1350 1351 1352 1353 1354 1355 1356 1357 1358 1359 1360 1361 1362 1363 1364 1365 1366 1367 1368 1369 1370 227 214 230 305 275 206 285 179 270 220 275 177 298 261 208 .. . 216 315 274 252 271 307 224 241 278 264 245 259 430 244 310 269 335 287 258 276 Mortality Data Liver Spleen Lune FMA PMA P PMA P P P PMA P P P p P P P P P P P P P P P P P PMA P P P P P P P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Skin X X X X X X X X AP00006602 Qttdudfoial B I O - T E S T ja&o4aia>U*4f Unc. 66 TABLE XII continued TEST MATERIAL; Vinyl Chloride CEthylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Spleen Luna Skin Misc. T-H 1371 continued 1372 1373 1374 1375 1376 1377 1378 1379 1380 1381 1382 1383 1384 1385 1386 1387 1388 1389 1390 1391 1392 1393 1394 1395 1396 1397 1398 1399 1400 293 316 250 322 322 262 316 234 256 369 278 205 232 275 176 217 340 273 295 251 256 183 272 297 329 498 277 498 212 448 P P P PMA PMA P P P P P P P P P PMA P P P P PMA P P P P PMA S P S P PMA X X X X X X X X X X X X X X X X X X X X X X X X XX X Kidney X X X X Kidney X X X X XX APbb006603 SudmiMaL B I O - T E S T JabonaioMt^ Sue. 67 TABLE XU continued TEST MATERIAL; Vinyl Chloride {Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats* Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Group Animal Number Days on Test T-HI 1501 1502 1503 1504 1505 1506 1507 1508 1509 1510 1511 1512 1513 1514 1515 1516 1517 1518 1519 1520 1521 1522 1523 1524 1525 1526 1527 1528 1529 1530 1531 1532 1533 1534 1535 205 225 258 221 206 157 294 229 220 258 272 215 284 283 295 256 302 293 312 263 275 312 222 277 312 312 256 252 265 276 195 179 228 222 210 Mortality Data Liver Spleen Luna P P P P P PMA P SE P P PMA P P P P SE PMA PMA 5 P P S P P S s SE P P P P P P SE P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Skin X X X X X X X Misc. Mesentery AP00006604 StvfuA&iiat BIO-TEST 2ai>o*aia*laA, 9hc. 68 TABLE XII continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-HI 1536 continued 1537 1538 1539 1540 1541 1542 1543 1544 1545 1546 1547 1548 1549 1550 1551 1552 1553 1554 1555 1556 1557 1558 1559 1560 1561 1562 1563 1564 1565 1566 1567 1568 1569 1570 276 263 178 227 232 247 253 208 208 312 208 276 263 276 260 282 295 269 267 224 254 278 273 261 275 294 180 235 298 206 240 220 309 191 312 P PMA P P P P P SE S s p p p p PMA PMA P P PMA P SE P P P P P P P P P PMA P P P S X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X XX XX X XX X X X X X X XX XX XX X Misc. Mesentery Ovary Kidney Ureter Mesentery Ovary AP00006605 SttJuditial BIO-TEST ^aL&iattyUvt, $nc. 69 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Grouo Number Days on Test Mortality Data Liver Soleen Lune Skin T-III 1571 continued 1572 1573 1574 1575 1576 1577 1578 1579 1580 1581 1582 1583 1584 1585 1586 1587 1588 1589 1590 1591 1592 1593 1594 1595 1596 1597 265 257 255 194 221 243 212 250 269 273 259 290 272 299 295 239 239 197 264 248 226 113 202 240 236 118 240 P P SE P P P SE SE P PMA PMA P P P. PMA PMA P P PMA P P PMA P P PMA PMA P X X X X X X X X X X X X X X X X X X X X X XX X X XX XX X X X X X 1598 1599 1600 190 P 268 SE 264 P X X XX XX X Misc. Salivary glands AP0bb06606 SnduiifUat B I O T E S T jalwato*le&, 3ho. 70 TABLE Xm > TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin Mlsc. Untreated 1601 Control 1602 1603 1604 1605 1606 1607 1608 1609 1610 1611 1612 1613 1614 1615 1616 1617 1618 1619 1620 1621 1622 1623 1624 1625 1626 1627 1628 1629 1630 1631 1632 1633 1634 1635 447 591 591 452 529 492 596 565 591 64 8 697 46 649 536 698 107 107 44 186 151 83 51 96 54 A PMA P P P PMA P SE P A P A A PMA A A C P c A A P P A P A PMA PMA PMA PMA PMA PMA C PMA C I' AP00006607 BIO*TEST ^afotatotidd, pttc. 71 TABLE Xin continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc. Untreated 1636 Control 1637 continued 1633 1639 1640 1641 1642 1643 1644 1645 1646 1647 1648 1649 1650 1651 1652 1653 1654 1655 1656 1657 1658 1659 1660 1661 1662 1663 1664 1665 1666 1667 1668 1669 1670 99 99 136 207 199 199 40 66 123 123 88 201 177 157 541 363 157 395 61 2 169 688 2 14 524 591 55 14 363 11 576 519 708 PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA P PMA PMA A P PMA C P P C PMA A P P PMA C P C P PMA P F AP00006608 Sudbuiteal BIO-TEST 2ah*ai&%i*L, $h&. 72 TABLE XHX continued } TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated 1671 Control 1672 continued 1673 1674 1675 1676 1677 1678 1679 1680 1681 1682 1683 1684 1685 1686 1687 1688 1689 1690 1691 1692 1693 1694 1695 1696 1697 1698 1699 1700 695 243 701 686 479 593 436 575. 325 511 651 246 108 108 529 430 530 467 319 503 121 303 P P A A A P P PMA P P A P A A PMA P P PMA PMA PMA P P A P P PMA P P A PMA ) f AP00006609 Stuhudifttoi, B | O T E S T $MC. 73 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin________ Misc. 1801 1802 1803 1804 1805 1806 1807 1808 1809 1810 1811 1812 1813 1814 1815 1816 1817 1818 1819 1820 1821 1822 1823 1824 1825 1826 1827 1828 1829 1830 1831 1832 1833 1834 1835 1836 666 61 59 85 44 382 371 589 100 100 533 575 622 631 137 191 148 100 65 164 111 175 607 523 51 375 649 607 377 108 108 108 108 A A P C c p PMA P P P PMA PMA P P P P PMA PMA PMA PMA PMA PMA PMA PMA P PMA C PMA P A P PMA PMA PMA PMA PMA X x. X X Kidney Lymph nodes Kidney Kidney Kidney X I AP00006610 Undttihlal B [ O - T E S T Ja&o*attvU*l, $hc. 74 TABLE Xin continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rets i Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin_______________ Misc4 T-I 1837 continued 1838 1839 1840 1841 1842 1843 1844 1845 1846 1847 1848 1849 1850 1851 1852 1853 1854 1855 1856 1857 1858 1859 1860 1861 1862 1863 1864 1865 1866 1867 1868 1869 1870 1871 1872 614 108 4 696 366 14 64 420 373 635 47 47 47 572 574 531 72 248 77 94 109 141 196 101 632 206 206 206 206 312 570 202 55 P PMA A C A PMA P C PMA PMA PMA P PMA PMA C P P P C PMA PMA PMA PMA PMA P PMA S PMA PMA PMA PMA P PMA A PMA PMA X X X X X Kidney f AP00006611 $Kcld44&Ual B/O-TSST ^ahyiafaUvi., Jhc. 75 TABLE XIII continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats. Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test T-I 1873 continued 1874 1875 1876 1877 1878 1879 1880 1881 1882 1883 1884 1685 1886 1887 1888 1889 1890 1891 1892 1893 1894 1895 1896 1897 1898 1899 1900 64 24 485 29 460 684 664 711 611 279 555 597 616 45 45 576 567 310 289 347 Mortality Data Live] PMA C P c p p A P A P P A A P P P P A C c p p SE A PMA A PMA A X X X X Skin X X Misc. Kidney Kidney AP00006612 $*tdn4&ilaL B I O T E S T ^akyia&yUet, Dho. 76 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin 2001 2002 2003 20Q4 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028 2029 2030 2031 2032 2033 2034 2035 2036 107 36 298 201 101 162 86 95 113 48 24 6 109 48 424 632 100 203 40 186 129 83 61 111 100 100 100 100 100 594 100 100 632 632 590 569 PMA PMA PMA P PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA S PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA P PMA PMA S s p p Misc. I AP00006613 HaduitrUaL B 1 O T E S T 77 ) TABLE XIH continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats* Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-n 2037 continued 2038 2039 2040 2041 2042 2043 2044 2045 2046 2047 2048 2049 2050 2051 2052 2053 2054 2055 2056 2057 2058 2059 2060 2061 2062 2063 2064 2065 2066 2067 2068 2069 2070 2071 2072 632 90 370 238 208 225 107 64 238 85 288 486 46 249 415 561 532 632 244 576 566 9 10 41 33 9 12 221 221 7 10 632 171 391 108 108 S C P P PMA P PMA PMA P C PMA P C P P P P s p p p c PMA PMA PMA C PMA PMA PMA C C s p p PMA PMA X X XXX Mesentery Kidney AP00006614 9HtL*it\ial B I O - T E S T Jsrf&iafoues, 9na. 78 ) TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen T-U 2073 . 632 S continued 2074 469 P 2075 44 C 2076 632 S X 2077 7C 2078 632 PMA 2079 101 PMA 2080 101 PMA 2081 127 P ) 2082 2083 632 93 S c XX 2084 632 s XX 2085 107 PMA 2086 100 PMA 2087 44 PMA 2088 158 PMA 2089 44 PMA 2090 590 P 2091 582 P XX 2092 2093 2094 632 632 9 S s c X 2095 2096 2097 388 32 528 p c p X 2098 2099 535 632 p s 2100 99 p Skin Misc. X Kidney > AP000066I5 SwituiAiai BIO-TEST Hhc. 79 TABLE XHI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Luna: Skin T-UI 2201 348 P X 2202 54 C 2203 405 P X 2204 192 PMA 2205 219 P X 2206 434 `P X 2207 231 PMA 2208 101 P 2209 206 PMA 2210 417 P X 2211 350 P X 2212 108 PMA 2213 367 PMA 2214 422 P XXX 2215 582 P XX 2216 179 P 2217 552 P X 2218 422 PMA 2219 219 PMA 2220 196 P 2221 386 PMA 2222 346 P X 2223 346 PMA 2224 346 PMA 2225 496 P X 2226 365 SE X 2227 100 P 2228 305 PMA 2229 330 P X 2230 441 P X X 2231 377 P X 2232 189 P 2233 422 P 2234 340 P 2235 16 C Misc. Pancreas Thymus AP00006616 UndiUhiaL B I O - T E S T dabafuatoMts, $hc. 80 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-III 2236 339 P continued 2237 591 S X 2238 529 P 2239 478 PMA 2240 270 PMA 2241 517 P X 2242 590 P 2243 591 PMA 2244 100 PMA 2245 477 P X 2246 484 P X X 2247 139 PMA 2248 404 P X 2249 147 PMA 2250 373 P X 2251 46 C 2252 137 P 2253 149 P 2254 278 P X 2255 295 P X 2256 361 PMA 2257 395 P X X 2258 547 PMA 2259 591 S XX 2260 591 S X 2261 508 SE XX 2262 46 C 2263 408 P X 2264 474 PMA 2265 270 PMA 2266 373 P X 2267 372 PMA 2268 39 C 2269 176 PMA 2270 351 P X Misc. Kidney AP00006617 Sadudhial BIO-TEST 2akvuzAyue<L, faz 81 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung T-III 2271 continued 2272 2273 2274 2275 2276 2277 2278 2279 2280 2281 2282 2283 2284 2285 2286 2287 2288 2289 2290 2291 2292 2293 2294 2295 2296 2297 2298 2299 2300 324 * 54 338 411 591 569 323 155 85 85 85 64 85 64 385 286 26 360 330 448 438 438 326 359 591 211 285 38 155 99 P C P P s PMA SE PMA ESC ESC ESC ESC ESC ESC P P C p PMA P PMA P PMA PMA S PMA PMA C PMA PMA X X X X X X X X X Skin_______ Misc. Kidney Mesentery AP00006618 $ndiUhial BIO-TEST ^ai)osiai&ue, $ac. 82 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated 1701 Control 1702 1703 1704 1705 1706 1707 1708 1709 1710 1711 1712 1713 1714 1715 1716 1717 1718 1719 1720 1721 1722 1723 1724 1725 1726 1727 1728 1729 1730 1731 1732 1733 1734 1735 632 632 23 43 414 426 559 106 95 137 95 7 7 68 104 116 137 505 591 629 495 130 589 404 91 131 128 410 127 127 454 23 70 104 271 S s c PMA P P P PMA PMA PMA PMA C PMA PMA PMA P PMA P P P P PMA P P PMA PMA PMA PMA PMA PMA P PMA C PMA PMA X Kidney ii f AP000066I9 Unduii'iiai B I O - T S T Ja&Ma&yU+i, S*tc. 83 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Group Animal Number Days on Test Untreated 1736 Control 1737 continued 1738 1739 1740 1741 1742 1743 1744 1745 1746 1747 1748 1749 1750 1751 1752 1753 1754 1755 1756 1757 1758 1759 1760 1761 1762 1763 1764 1765 1766 1767 1768 1769 1770 1771 1772 411 103 411 97 611 168 351 79 415 52 54 592 530 118 166 65 30 233 53 194 373 59 595 208 147 147 89 307 53 582 541 567 575 47 367 116 116 Mortality Data Liver Spleen Lung PMA PMA PMA PMA P PMA PMA C P c c p p PMA P PMA C PMA C PMA PMA PMA P PMA PMA PMA PMA PMA C PMA P P P C PMA PMA PMA Skin Misc. AP00006620 SadHiUial BI O - T E S T Jtai&uit&ii&L, 9**c. 84 ) TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Days on Group Number Mortality TestData Liver Spleen Lung Shin Misc. Untreated 1773 Control 1774 continued 1775 1776 1777 1778 1779 1780 1781 1782 1783 1784 1785 1786 1787 1788 1789 1790 1791 1792 1793 1794 1795 1796 1797 1798 1799 1800 193 P 198 P 249 ? 267 PMA 283 . PMA 114 PMA 190 PMA 362 PMA 340 PMA 314 PMA 38 C 200 P 587 P 27 PMA 341 PMA 43 C 571 P 464 P 193 PMA 435 P 14 C 400 PMA 542 P 536 P 506 P 539 P 547 P 531 PMA AP0d00662l 9tub*it/tfal B I O T E S T Ja&MdfoK'ed, 9*tc. 85 ) TABLE XIE continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats* Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin_______ Misc. T-I 1901 104 PMA 1902 187 PMA 1903 188 PMA 1904 141 PMA 1905 394 PMA 1906 153 PMA 1907 200 PMA 1908 57 PMA 1909 84 PMA > 1910 200 P 1911 113 PMA 1912 201 P 1913 108 PMA 1914 1915 120 131 PMA PMA 1916 164 PMA 1917 580 P X 1918 49 PMA 1919 49 PMA 1920 131 PMA 1921 106 PMA 1922 311 P 1923 119 PMA 1924 1925 119 119 PMA PMA 1926 133 PMA 1927 61 PMA 1928 52 PMA 1929 127 PMA 1930 572 P X 1931 578 P 1932 94 PMA 1933 81 PMA 1934 74 PMA 1935 1936 126 191 PMA PMA Kidney X i I AP00006622 StiduS&Ual BIOaTEST P'fhnAsifiiAfof Stic. 86 TABLE Xni continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test T-I 1937 continued 1938 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951 1952 1953 1954 1955 1956 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 191 180 185 66 473 553 417 54 493 435 451 608 47 53 83 467 476 313 47 51 59 578 632 544 632 40 56 86 174 33 31 107 178 592 397 411 Mortality Data Livei PMA PMA PMA PMA P P PMA C P P P P C c PMA P PMA PMA C PMA C P s p s ESC PMA C PMA C c PMA PMA P PMA P X X X X X X Skin Misc. Ovaries r AP00006623 $Md*4dt*Sal BIO-TE5T Jahonativii&t., $hg. 87 TABLE XIU continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin_______ Misc. T-I 1973 continued 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 524 14 467 31 371 487 86 577 581 494 424 542 94 128 207 193 65 389 55 488 493 24 191 632 33 144 603 88 P C P C P P PMA P P P P P PMA PMA PMA PMA PMA PMA C P P C P 5 PMA PMA P ESC X Ovaries X Ovaries AP00006624 Ottdudi^ial BIO-TEST JLatxwitoM&L, Sue. 83 TABLE XHI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number T-H 2101 2102 2103 2104 2105 2106 2107 2108 2109 2110 2111 2112 2113 2114 2115 2116 2117 2118 2119 2120 2121 2122 2123 2124 2125 2126 2127 2128 2129 2130 2131 2132 2133 2134 2135 2136 Days on Mortality TestData Liver Spleen Lung 602 P 9C 486 P 545 P 476 PMA 553 P X 451 P X 392 P X 514 P 578 P 570 P 336 PMA 52 c 476 p 632 S 529 p 52 c 632 s XX 87 c 60 c 39 ESC 509 PMA 632 S 39 ESC 446 P 221 P 562 P 576 P 286 P 513 P X 129 PMA 495 P X 173 PMA 208 P 447 P 413 PMA Skin Misc. X Kidney Kidney X Mesentery X X X Cervix X AP00006625 fucLtiitfal B10-T E S T Jabyiato,\ie&, $nc. 89 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Luns Skin T-H 2137 continued 2138 2139 2140 2141 2142 2143 2144 2145 2146 2147 2148 2149 2150 2151 2152 2153 2154 2155 2156 2157 29 47 359 29 39 522 68 36 36 522 104 603 46 628 426 307 632 614 207 542 632 C C PMA C C P C C C P PMA P C P P PMA S P P P S X X X X X X XX X 2158 2159 2160 2161 2162 2163 2164 2165 2166 2167 2168 2169 2170 2171 2172 564 614 473 96 96 96 534 541 200 485 196 468 632 409 383 P P PMA PMA PMA PMA PMA P P P P P S P P X X X Misc * Thymus Ovaries AP00006626 2*tdudhlal B ! O - T E S T Jal*viatvue&, Ottc. 90 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Grouo Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-II 2175 456 P continued 2174 469 P 2175 541 P 2176 466 P X 2177 462 SE X X X 217B 2179 492 53 P c 2180 566 P 2181 570 P Kidney 2182 9c ) 2183 514 P XX X Cervix 2184 520 P 2185 202 PMA 2186 470 P 2187 261 PMA 2168 212 PMA 2189 194 P 2190 245 PMA 2191 541 P X X 2192 2193 536 29 P c 2194 193 PMA 2195 508 SE X 2196 625 P X X 2197 596 P 2198 2199 632 558 S P XX XX X Ovaries 2200 547 P X AP6bb06627 $*tehiifaal BIO-TEST Jja&M&t&ue&T Dhc, 91 TABLE XIII continued t TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin_______ Misc. T-m 2301 9C 2302 74 PMA 2303 149 C 2304 591 S 2305 320 P X 2306 309 PMA 2307 314 PMA 2308 304 C 2309 201 C 2310 118 PMA 2311 206 PMA 2312 201 P 2313 2314 390 64 PMA PMA . 2315 247 PMA 2316 300 PMA 2317 318 P X 2318 315 PMA 2319 249 PMA 2320 2321 207 360 PMA PMA 1 2322 381 PMA 2323 403 P 2324 361 P X 2325 350 P 2326 498 S XX 2327 390 P X 2328 354 P X X 2329 448 P X 2330 354 P X 2331 2332 398 498 PMA S X 2333 496 P X 2334 411 PMA 2335 89 C AP00006628 Unduikial B I O T E S T J*t& 92 TABLE XXII continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Livei Skin T-m 2336 442 F X continued 2337 405 PMA 2338 399 P X 2339 87 C 2340 409 P X 2341 490 P 2342 219 PMA 2343 286 P 2344 403 P X 2345 332 PMA 2346 2347 2348 419 403 8 PMA PMA C 2349 41 PMA 2350 54 C 2351 96 PMA 2352 118 PMA 2353 244 PMA 2354 2355 359 8 P C XXX 2356 353 SE X 2357 48 C 2358 2359 385 207 P PMA X 2360 2361 352 96 P PMA X X 2362 100 PMA 2363 96 PMA 2364 96 PMA 2365 96 PMA 2366 96 PMA 2367 305 PMA 2368 439 PMA 2369 591 P X 2370 407 PMA Misc. Stomach AP00006629 SnduA&Ual & I O T E $ T Ja&oteUtyii&i, f)nc. 93 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations In Female Hamsters Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin T-III 2371 continued 2372 2373 2374 2375 2376 2377 2378 2379 2380 2381 2382 2383 2364 2385 2386 2387 2388 2389 2390 2391 2392 2393 2394 2395 2396 2397 2398 2399 2400 367 383 390 379 61 68 53 264 207 49 38 279 279 306 378 387 364 207 194 325 38 364 29 243 361 29 41 84 397 208 PMA PMA PMA PMA PMA PMA C PMA PMA PMA ESC PMA PMA PMA P P PMA PMA PMA P C P c p PMA C c PMA PMA PMA X X X X Misc. AP00006630