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7. Serum Perfluorooctanoic Acid and Hepatic Enzymes, Lipoproteins, and
Cholesterol: A Study of Occupationally Exposed Men.
This is the published paper (Gilliland and Mandel; Am J Ind Med 1996,29:560-568) from the Gilliland doctoral dissertation (see study # 5) that evaluates the effect of PFOA
on hepatic enzymes and lipoproteins. This study of 115 occupationally exposed workers
examined the cross-sectional associations between serum PFOA (measured as serum total organic fluorine) and hepatic enzymes, lipoproteins, and cholesterol. There was no significant clinical hepatic toxicity at the PFOA (i.e., total organic fluorine) levels measured in this study. Based on multivariable models, PFOA may exacerbate the effect obesity has on liver transaminase tests and blunt the effect that alcohol has on HDL
levels. [Note: In three subsequent time periods, the findingsofthis study could not be replicated. PFOA, assayed by mass spectrometry methods, did not appear in this production workforce to modulate hepatic responses to cither obesity or alcohol
consumption. See study #8 below.]
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AMERICAN JOURNAL OF INDUSTRIAL MEDICINE 29:560-568 11996)
Serum Perfluorooctanoic Acid
and Hepatic Enzymes,Lipoproteins,
and Cholesterol: A Study ofOccupationally
---
Exposed Men
Frank D. Gilliland, Wo, rho and Jack S. Mandel, mo, ww
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KEY WORDS: perflorooctanoc acd, human, hepatic encymes, cholesterol, HDL
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REFERENCES AltA pe. Varn1 isn . Rts 190 per
iofcfaectdorsi.nOinlsy sacttidve 1workrers lin PiFstOtiAmoiperrdoedbusyctaiwomhnobweerer.
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pos C JUSS TMe! n](19e9)t MS ortysn nong empopess in FOXi
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