Document gbo7m0Bajn5r2meaN4Kop0EmQ

NEW YORK UNIVERSITY MEDICAL CENTER A privttt univenity in tht public service Institute of Environmental Medidne JJO FIRST AVENUE, NEW YORK, N.Y. IflOtt area 212 5281 or (914) 351-2566 ANTHONY I. LANZA RESEARCH LABORATORIES AT UNIVERSITY VALLEY LONG MEADOW ROAD, STIRLING FOREST, TUXEDO, N.Y. 10*7 MAIL AND TELEPHONE ADDRESS: S50 FIRST AVENUE, NEW YORK, N.Y. W01S July 21, 1983 PLAINTIFF'S EXHIBIT Nancy Harvey Steorts, Chairman Consumer Product Safety Commission Washington, D.C. 20207 Dear Chairman Steorts: 1 transmit herewith the report of the Chronic Hazard Advisory Panel on Asbestos. The Panel concluded that on scientific grounds and as a matter of public health prudence, the Commission should regard asbestos at all levels of exposure as a potential human carcinogen. We recognize that such a conclusion in the absence of means for quantitative risk estimation confronts a regulatory agency with a difficult dilemma. Accordingly we have developed, and include in the report, a suggested approach to quantitative risk estimation (albeit with appropriate caveats as to unavoidable uncertainties). This report has perhaps been more extensive than originally planned; however, as the analysis proceeded, the Panel became convinced that a thorough examination and presentation was important for the support of the Panel's major conclusion. However, in order to meet the requirements of readers' varying technical backgrounds, the Issues are developed at three levels: a brief summary, followed by a somewhat more technical exposition, which in turn is succeeded by a detailed and fully referenced section. The Panel has extensively discussed and reached agreement on almost all issues; in one case (which is identified) it was unable to reach total agreement. Thus the report as submitted has the complete concurrence of the Panel, and the members have so Indicated by affixing their signatures below. 005827 Chairman Nancy Harvey Steorts consumer Product Safety Commission Paae_l With the hope that our efforts will be helpful to the Commission, we respectfully submit our report. App Wiliam J. Nicho QdAMjh Jahet H. Hughes Sincerely, Norton Nelson, Chairman Chronic Hazard Advisory Panel on Asbestos Jullah Peto d 005828 Report to the U.S. Consumer Product Safety Commission by. the CHRONIC HAZARD ADVISORY PANEL JULY 1983 U.S. Consumer Product Safety Commission Directorate for Health Sciences Washington, D.C. 20207 005829 TABLE of contents Table of Contents List of Illustrations List of Tables Panel Members Acknowledgements SECTION X ~ SUMMARY A. INTRODUCTION, SUMMARY AND CONCLUSION B. CHEMICAL AND PHYSICAL PROPERTIES OF ASBESTOS C. LABORATORY EXPERIMENTS D. ADEQUACY OF HUMAN AND ANIMAL DATA AS TO CARCINOGENICITY E. NON-MALIGNANT RESPIRATORY EFFECTS OF ASBESTOS EXPOSURE F. DOSE-RESPONS" RELATIONSHIPS SECTION II ~ AMPLIFYING INFORMATION G. LABORATORY STUDIES INCLUDING FIBER DEPOSITION AND CLEARANCE 1 Introduction 2. Animal Deposition and Clearance 3. Human Deposition and Clearance A. Models of Deposition and Clearance 5. Inhalation Experiments 6. Injection and Implantation Experiments 7. Ingestion Experiments 8. In Vitro Studies H. CANCERS OF CONCERN 1. Lung Cancer and Mesothelioma 2. Other Cancers Page i iii iv i rii 1 7 10 12 15 19 26 27 35 40 42 45 49 53 56 56 - i- 005830 TABLE OF CONTENTS SECTION II - AMPLIFYING INFORMATION I. HEALTH EFFECTS OTHER THAN CANCER 1. Asbestos Bodit's 2. Pleural Plaques 3. Asbestosis J. DOSE-RESPONSE RELATIONSHIPS 1. Age, Tine, and Dosa Dependence 2. Dose-Response Slopes 3. Evidence of Fiber Type Effects 4. Cancer Risks et Low Levels 5. Conversion of Fiber Measureaents List of References *3S 67 69 72 78 95 124 128 134 138 - 11 - 005831