Document gbnBrLLa1XyN5RmQaM6xMBqLV

BKfaa vo vsat mkmtiq caaacua ccavoar *r Owtt X. PtUktr, KsB. Sms ul Mnwr r nqrstUcr teritl SotetiX (f TuMla 0*ltk, Boeteo, Uu. 5*ytA^r 35, 1990 PLAINTIFF'S EXHIBIT _ . 11 MOMS 0M123 HARTOLDMONOOI5007 I HARTOLDMONOOI5008 X. jgggflgjP TO or TKI yoiXOLUg BUWn*lH ' On 7nly Li, 1WT, no we lafanoi by 7. . Oslth that niIi I ommi bettlt of a soft drill* ai*Vt ooatala *0 to TO apt, of ehloreceaiM. Item i ao pharmeologlw 1 reaeoo to believe the anofomd uoold Vo irrltatlac tecIt in any nor. and 1 bomfere it vu IhIM to doeo rota with it Tory heavily, the arguaaet Volai; that if they enrvived heavy dooeca without toy evidoaet of 4--of a Ttrilt* of so taaleity *i$)rt Vo (It* ui ask tlae MTti. If, tfeo otbar band, tljo lory* Ooooo proved polaouoe* it uoold Vo aoeaaaary to reduce donate until ij aoa*toxio level nos reoched. TVo firat of thoaa elteraetlvee prtrroj oorroot. - Pincrlwonto. -- August 10, 1T97. W edult ufclte rota rescind 1 eeiylil from 1C3 to Hi c< nor* eee> fed TO ape, of ohlereoceae in 1 oe. of Olivo oil doily Vy atomih tuVo. Ihoaa anlaale abooed ao evidence of intp ia osy noy attriVuteVlo t > ehloreoeeae. Uwy voro ezwlaed aieroeeopleolly froo tho soth to tvo (2nd Ao r, The oaly eonetont ebaneo oVaarvad uoa a peaclble allGht inornooe in tbi yramilarity of tho oella of tho llvar torit, but tho yotholosiot ia abarft fait thia to Vo mthla aeranl liaito. Thlt fiadlnc la doubly roaaaur >| aiaea poay of tho aalanla developed a chronic MppuratlTt lui>- oondltloa vary prevalent la Sottos stock rota at tbo tiho. lXit rrna with this addtd ban leap them sea ao ovldenco of daaoce and no tkua eonclado that ohlerooonao ov^a la oaemeua doo*{* la laort ueteriel in thv body nad in cl.* probability poiooo tirtmr* tho lotoctiaa uaobaaevd. SONS 048125  s. Birmra nxsajn * tecaJt at 113?, W Mil lsforMd Vf ftp, X. X. Xelly that dlytosyl ' phthelete ai| at t atoortod through tte skis or adght to Inhaled end c*alio*ed dwts* spray 1 >d operations. After ooasaltatloa It was too] tod to food toavlly, ad IT thoro >oro ladlootlooo of toxielty to jrejsst otter axporUMats, tonorino ita. -- Beyteafcer >0, 193?, 80 adult white rata rtnglnc la weight fren Ml toDlfb wars oaoh f*4 0.3 nps. Of diphaayl phlbelate awpandad la 1 oo. of Mtc hr otoaaeh tube dally. Tto aBinala mere fro* an stock end with om rat; >tloa reaalaed clear of tto 1*^ eoaditlou vhlflfc existed la tto ehloreeeeae c 009. During tto >eri4 of exyerleant, toleh looted 92 ioye, rrootleollr a:i tto aaieele gained weight, Xmeelnatioa of 8 salual* killed ot intervals 1 arise this period of toot roonltod oo follows! Tto orcsx ooro neml P'osoly, end on derooeople oxonlnotloa tin llvtr olono was of joeslhle Intoroot. Tto changes in tto liver verted fro* thooo la trhlab tto eclli of tto liver cords euro alaoot acral, tor tag only a client welling and granularity of ttolr aytoplaaa, to those is wblek these etoacss were pronounce 1. Is the latter there was a Moderate tocree of voev<llx.tloa es<1 a rare hyaline hefty. Ttoaa alterot ions It sraat to uadcretood wore tto result or very eortoia dosage, since tto eeapeusd woe given by eteeeeh tuto ' ond tto onlael 1 tod no forcible my of voiding it. Wrlltor tto pot! 101051 t nor Myeelf woe able to eeeolder then of enough noneat, to cause uc to Mihe further expert ei. Z an oonf: deat that with tto ordinary precautions oeetaupenyInn ejrny ltenoerinc so jecelbla torn oevld he done, eves If tto concentration of dlrtonyl phUnJote In tto leetpjor wan Tor nbeve tto B por eent fjgurt r.*Y* ue by 8. X. Kelly. HONS OVdlfd hartoldi^ t. ohuhokass mraam. -- ootrooc #iato * Thlo aot4ui wi turml*ad by tba Donmi\ Obanlaal Ooi*>tsy. It mi M to km a jikltrlM rntwl of M par mt, tba kl{kMt ahlorloa (ljun of ao; tartad ky trU( tb* yut tfaraa pm< It had MOB our li*>moslce that- toKlolty aad ablerlaa oostaot followed ooa rootbar eloaaly, but tfeio baa ao^ tint! out to ha tba aaaa for #1888 .rrtrToTOWuaotlMccttb further dlaouaoloo of Otis yolat will follow tba daoerlptlen of tbo ixyartMjitil obaarratlooe and tbolr remits. ^raorluont* , -- |ut I, HIT. 9u oca^ouod #1168 m edulBletured ky lahalation, tba taobnlQuo bolic tbct described la tbo poper oatltlad Tba frobla:t of Poeolbl* Syr onto Effect* froai Carta la Chlorlaatad Hydrocarbon*. Journal of Industrial fljr*iifftm, 1997, |t, BBS, tor tbo firat obnarration* 90 adult ablto rota uera wood. They vara ozpoaad a* follouos Orcup 1. -4 80 aalnal*. faqpamtnra to trtiiob lha ecrpouad pd* boated to' lutrodiaea torn into air 11m 1*0-190* C. Jtrorapa ooacentratlea la air braotbod by rat* 0.55 ap. par oubla aotar. Arertc* dally exposure 10 hours, Tbo inntlnuod for 119 days, ewiaal* being seer)flood et Utanrtlt for putholoeleal an rinalien and for tbo enrbon tetrachloride and alaohol test (* paper prrriwaly el tad). Hio ee*idltlH Concribod sbovu euurod swelling cad lneroure of cr~T'l|lnrlty of tba llvar ealLa. HynliM Inclusion* van ram. Tbaaa rhnnsss wu suite unlfona in all ailmla osoalaad niter Ute Slat day, but were not eartrlnly preeraaslva. 7bi rats war* uorjr baalthjr throubout tba parlod and tbnro naa an aimit uni fora gkln Is weight. Tba curboa totraohlorlde-eloohol toot r*>o josltlr** after O f dry*, thleh lndleater thut though liter diJXiya wo* apparently Might cute; dup-re pf bi.*i: had been duao the orcin. There uan no arideuee of MOMS 0*8121 ia mj pari of the body except tbs liver. At tlM i 4 of 5 ttf 10 nti, oywwUy ia m*U*rt iwditSee, 4 frota the eapwiaent *< Mt eslde for observations vpca liver roeovary. rum recover r aalaala iMw4 mo dialeel ehaaeae of any sort. Vbea aoerlflead T and 111 Aero after reword frea ospoevro It Mi observed that the suelliae of the liver all* had liiiffovot, Vat the *numler tad hyoXiao severlaX roals* la 1 to liver telle aad hat mertitXjr Immi jonoiMt, Shore see absolutely no pro^eseloa of deaegs after raoevtX free exposure. fboto JhO0M any Vo oospore! with those protest! la rate by iaValatlea of ehlorlnatti l diphenyl #4468, eAelslstored ia a olsilar naaar ia eoneontretlona of 0.57 to 0.93 ora. per cubit rotor error elnlXer periods of Vise. 2a the eees of t! its eoepeund the eenspleuevs !lffsreaes wee tl.s for creatsr incidence of 1 ydlalsetlon of the liver telle, vdileb la our opinion woe the eherNetcrIctli Xeelon erased by (?44M on! sizturee containing it. One eon therefore ooa<lu!e thet #1X60 la lev eoaoeatretloas is definitely lecc toxle thoq #4440. Croup t. -- After Ilf !eye, tbs leu eeaesotretlea of #1X68 baring proved but slightly joSsonoue, It wee dselds! to Increase the eoneeiitrr.tlcn la tbs air brsetbsd by 11 e M rule tbea revaluing. Tbspereturo and other conditions were 'snlntMr.sd ne during the first 119 dope, but by the ucu or < vtii^rlwirt. .Instead sf 1 tie nvorri^a ooreerIrrtloo of 1*1760 la tbs nlr van transit to C.W wpa. per cubic nwter sf air. Brpeeure to this very high seor-satrtt 1 on ms continued fw 07 days. Under thebe ostium conditions the mlanls egnin rcaoinod la pwroet iieuli;.. The t j-bon trtrtlorl4c trd uleo^l test r<v- *nltlve but ll.erti tea absolutely r* >tber Indication of liver deenc* end so erM^nec of dleturbur.uo to olbiir orv^r.;. HOKS 046126 HARTOLDMONO015012 jaiMl ot MUfijr at tki i*d tf It 4aye -- tk< m^ m cxperlaoeed U tW oxpoonre of M dayt -- tter* m no croai m(mn or abnormality |U any rmrX, On aieroooople oxaainatlon as orpna ebooed ohuoa oxoopt tho liver. Tho biw*ii of oalln containing hyalin* ad the mnut ; Iqrolln* la i m oolla involved inoreeeod during this period of axpeairc to tba blfber ocm itretlon of #1XM. tba bgrnllae mj wot nbuedwt ia tba portal zona of tba labeli with vary llttlo la tba oaatral ora. Aftor dft toy of expoeore 10 rata oora act oxide end am eaariflead 19 daya lotor. they ware la oxoollnt condition nbep reaeved oof 414 act ebaagn. Orooaly, t outopey, tboy shooed nothing eboertml, and oo aleroeoople examination tba I Ivor oolla ted loat tboir welling hot foUiaed lncrenaad granularity oa< hyaline Indue Ion*. The expedneata oa lahalotiogo of bl^t eoncaatrntlona of #1X40 roaaforoo tba oeulwlai that tbla eeopotmd la of loo toxicity aa anayarad with #4445 or with chlorinated aaphihaleaea above trlehlnmopfcthalone. Zte guestiem aa to uby #1X40, tba ae^t highly chlorinated omyowaf tented, proved bvt (lightly baneful cannot bo oMnprad with any definiteness. It boa boon euggeaVcd that tba toxicity of all thcoa abler lasted eocgiouada, even though of varied eompoaltltm, aajr depend ao tba ability of tba antool to daoctiooe tba* after loCp*cnt la tba tlaauoc, oad t at tbla daaowcclbloo night be abeam by aa Inarooaa la tba chlorine la the urine u, rultrbly oooduetad feadlnr oxporisnntn. In axpcrircaU upon this point we have t bow o deflalto Increase la tba urinary chlorides then does a'.rt rata vrre fad i nlrture of peala and bvxschlonuphihulijw'S (flOOG), a compound bl$bly Injuries to tho liver and eoatalulng C4.4 per coat of chlorine, bat iloiiar obaarvatlem bora not boan aado xlth nay of tba ebloriaatad diphenyls or allied eoM)>owii. It i my, botrver, be tlat trbun bcut 45 jmr cant ablorihatloa la nr.-ehi-J tbo eul>etrw.ua orrd era ;ulto itatln in tba body aal co eeueo Diulci* of 1mi*Si * . HONS 0*412* HARTOLI /I I 2a MHljwlN, /1>M, -it kutM with crtiawry intmtim aa Vo tentllotloa ilmll V r oatlraly haralaaa to wertnoa. VUli it aanaot ha voa aa itetht*]} a! a hill aa to hoolth* It la yreforobla to #4419 iM fMU. a 4. icpsun cf chidmmh> tmma. joo ogtmvwrm omsan. -- OOUKXM #M0 Ifcla wtiWM* woa NniiM by tho Moeoaato Cbaalaal Ooopony tad wi mu to hrra a Okie 'Lm aoatoat of 40 par wt, bolay la thla rwayoot holow /444b wa far holow #1W I. fauorlaag a. -- The lahalatloa toetel^uo woa wood as la tho ear-a of tlfa'-0 Ud #4463. Aouat t, ItST. 40 adult wtilto rota wore tho ovb/eeta. Toa^craturc to ciUeh ttoo oon* ual *ao boated to latroduoo fiao late tha nlr lire 14D-1M* c. Aroroya aoaocatratleo la olr broathod by rata 0.005 Ufa* par ruble water. Aeorayo dally OQiooura 14 houra. Ttm 'oxporiaaat lootod 119 daya. a eoririu auwbor of a&laala ware saerlfieod for pathologies! cnmluotion, other*; tore ' uaod Ter tho eg`bon totrichloride aod aleohol toot, aad utlll othorr *rt taii*o for oboarTotloa i oa to rooorory froai poaolblo damyo. la oplte o' tho feet that tho eoaeaatrctloa la tho fir breathed tho r-.ir Tbrteod about I/4 that obtelaod at oorporahla ta^arso- a Trvt. "lEK*. i ni if of thaaa aalwoli boerne alek ood loot woleht towards the tad of the r.pcwd t-.v.-t.'i of axyoowe. Woa killed, auob Individual# ehowad cr> of tl.c llrtr but ao cbanoca da othar orcoat. On wleroeeoplo axoalnattoo swell liif, or tho llvor eolla, lucjronecd (yamilarlty imd hyaline lnolttuloi.i t;.rw xotwj ii* i :U killed aa early ha tho 16th day of expoeyre. Those ehaof.t!* obrlounJy tcr.urr.i) rojitdly. Kyrvllnp deposits woro aoror oa aunoroua aa with jflfcfiO. /r.lvula HONS 044130 HARTOLDMON0015014 rwBTi< ter rMcverr after H aad lit far) >f wpoeare 111 net ! wnrkaaiy 1b welfbt, and |om 41*4 ter me obrloue um. Cbea exmalned *t autepey tbe mUlae of tfa liver eelle M wfalfal, bet ifaenel creaularlty Iqrallalaatlea t|mmi1bo4 needle** eey tb# earboa tetraeMerlde tad eleebol teat aae poeltJva whenevw seed. 1* Tien ofj the feet tbet #OtdO 1b aaob lee eeBOeatreUea rw*l ee defialtel/ inlf, bo bibber eoBoeatretloae em teeted. It imb Imperative tbet whenever tkl* icwwibI la eed la ladaetry, peat bare be taken to keep eoneoatretlem is the air at aa estreaoly lew level, lie llbertivt esu be tefcen vltb It, L with flkCt. HONS 041131 HARTOLDMONO015015 1* ddditloa to ttoee toot* of tMpcuali, oertalo n^rlatnu ear* ahiak OT* Of ataraat to the** samfaeturlat or uatoe M.eriaato* tqrtreoorbcoa totalla u to thorn ozporlMito or* of leoni mtlAU tot or* Ml tMlutnt to tti* roper aim* ttojr *t of dlroet ladaftrlal lntr**t, i. mum ns ns xesswcnM or a ixouat or rum. add . BSCMBUfOUnnUUSSf (flood) at nac aonr Xt has ml r*y* Vmo a caaatloa at to whether tbo ehicriwtad fcgrdroeertoao ehleh kora toe a axnalnad by oaroalvoa and by ottoro do ton nor ao or abattor texielty da; ea ttolr broekdoaa to tto tody eltb tto liberation of *ene tVisc torarm tto llrar. A partial mew bos tooa obtained bjr feodltic flOOd to rate i d dec* tolob tear* oa a lew ehlerlde diet with oalfoza ' xentice of o: Aoridus is tto aria*. Uhea ttooo asiaelo r*eelrd tto ohlortoatod hr irooartoe (flOOd) tto arlnary ehlorldeo roac; This iodicatoa that tto tody i ertalaly too power to `detach ehlortoo free this euujwuad, cad it ia jntcM* that tto sen* ecedttlcn ia true for allied texie compounds. It mold to sect istoroatisf to ooe tinttor lncaatioa of fltfiO rcsultr. in slrller fladlnsa or whether la tto ease of this relatively nuo-toxle eu.^mwi there lo practically ao tplitltof Off of obloritia. neither tie* w our financial raoouroao peal tod eueh toota. moms oadiiz I -lo se Miner at nocaurco as soon*; cuukioc a tat put vrat mnum BKsxraa asao seas op /loot ta the pound thot ehlcrldoa Bight ha f-- daaoatally ibmIiM with teocielty, o poop of IS rota eoa fed a loc tesla leaa of flood and ocayared 1th a a 1*11 r grvny. oi the im doeac* of flood plaa a narked inerecao la ahlorlda lati ha ooecrod *7 giving I aa. par kUecna of Mgr might of 4 gar oast XaCl eo^atloa dally Ma dlff< aa ware Smad hotaooa tha tea groupo, and It aay ha oonaladad that ehlorlnai laaraaaa aaearad through tha dlat doaa aot aahasoa teolelty. Xhla exgerlxut aaa dMia la ardor to flad out thathar laeracaa la chloride Intake during hot aether Bight ha harafol. A partle tier phase of tha preplan, tha poealblo afiNmeascot or typleel akla laaiona 17 lnereacine ahlorlda ictek^ eenaot V* daell.fi by exparlcenta oa for-haorlB: aalaala alth ao aahooaoua glads* All thet ees he said at tha accost la that laoraoaad ehlerlda lntaks does not laeracaa ayatonic toxicity. s* rm svser op jaau akd jjou calcium Ziir.jx cw ja.njuf. lioiAiss me: rc.cx.nvncw c? ,'ioov It la veil knocs that o dlat rich la soldo* Is mrkadly effective lc preventing the east# yalloa atrophy of tha ltrar produced Vy earbon tatro- ahlorlda (3ha : rerantloe aad IVeateent of Curbon tdrocUorlfie latexiactlcti. By y, 9. Ilcsm , K4>,, a. S. UMt, fli.V., end B. tl. ftebbicr, Jourral of the Africa})' UrfiJed r-ceee Jot Jon, 1*20, volut* W>, MS), . To dlrem-i ahc'.Iwr ccieiu-. In the. diet vrr.lt! propel t^.-.lnst 3Jv*r ,;r mohs o t U 3 HARTOLDI tnm toarie ehlerlaatei hyfroearboa, 90 adalt nhlto rata *m placet ?ea a 41st af loel ton--ti atOTk and. lard, a aeafelnatlee adetaste for OKlatenanee ton rwy )4 la Nliia. Mtlkv group h (ltn a Alai tmlitui tf dog too*, nik, Mi-- -- eggs, alth added ealeluo laetate -- a ratios Tory U|k la' tCilau otto a oar* expeeed elsultenaouelr ta iabelatloo *f high aaoaestra- *1-- of |U6, am average ef Ufa. par ettfla meter far 14 boors a day. 4ftar If dare, 1* high aalalw diet rata tiara alive eat T at lb# lea aalal-- amb. At laterals ealaala ear* killed forexonlnstica. Xa tooth groupe tba liver w aboonml greesly --4 alerotaopleally, aa4 is tooth grwpa aalsale <14 jtna liver dosage. It mi Impossible to eoaelder that the bleb oalaloB 41 vt )me la tl* leuet degree protective. It nay, therefore, toe oceluded thajt adding ealelum to tba 4iet ef aorkara either la the fen of astro milk er| of aalaltaa lactate will set prevent liver datrnge. ' 4. at BY9CT or XMXCROB Of 00018 CU AHXUUA DSIUBS HIGH CCnCSOXAnoiS or |1006 In 13?, k. o. Neale published a brief paper (The rroteetlve Action or Certain PurlMi agnlnet Liver Hoeroela Produced tor Carbon ItetrseUoridr end Cblorofom. 0 ileaea, 1*97, volute 66, pace SB), Ho elntaod that rata lajseted nth wdlun xanthine toaoM nerkodly rwijeteat to onrtoee tetrachloride. This auecaatad ttost xanthine adght hove a taller protective power rear liver danaoa frw thj chlorinated hydrocarbon* on erminatlcc In thla laboratory. Accordingly 96 adult white rote earn oaveed to Injrtln 1006 In cci^ent.ra tions overoRlnd 16 mo** per euble notrr for 1C hours dally, on* croup of to rate vaa p#vo to of santhlnn subcutaneously evory other day and 40 HONS 04*13* HARTOLDt f mlUM Iff itaMk ww Ml 1M ilttmt* ter** * * P*9 *f It nti M DU MM jHtfOOQ* to #100* lltttH NMthlM tTMtMkt* *0 ItffmiHI Mr* MMt |Ht or mM7 fro uktuai ottlMr Is tkt or tmtant liw Unm m to ftfcio ohlorlaotoi )qr4rotoa, *a4 U all jrottMllt? t^ tot aogBllYo noult oS4 to aooootorot U noiitlo oltli 111*4 toil* HONS HARTOLDMON0015019