Document gbYLkmvd77V1xn30QM2pwJLQJ
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3M Medica Deparment
EHR- 1105_ 0037 4
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05HOV23 Mil:05
November 16, 2005
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Re: TSCA Section 8() Supplemental Submissions: Docket Nos. 8EHQ-1180-373 and 8EHQ-1180-374
Dear Sir/Madam:
CanTans NO ogy
3M has previously submitted analytical results for serum measurements ofvarious
fluorochemicals. described below.
As a supplement to those submissions, 3M provides additionalresultsas
Two female fluorochemical plant workers provided 3M through their private physicians and requested that 3M
with
serum
samples
for
their
children
tachhpeiplwrdoorrexkniemwraestrpeealrs8ytaimmcpoilpneatdth,esd,ointneentmimoentehacsh,andTotwtoheyebeasrtsooffa3gMaen'asaltyuztnehdeetrhtseitmsaeanmdopiflnesgsa,.mtphlAeinctgho.itladlArotefntthwhereterieeme,
fluorochemicals. This prog3rMa'msdoocecsunpoattiionncalludmeedcihicladlresnu.rvTeihlelasnacmepplrionggrwaamsfdorone at the
requestof the mothers.
Worker #1 had one child sampled, in the fallof 2000, when the The mother's blood was sampled in the fall of1998, and agai
child
was
about
10
months
old.
ltehveeblasbayr'espbriorvtih,daesd
phaerrteoftto hofeferregsuolmarelycosnctehxetd,ulbeudt
n in 2000, several months after
otchceuypdaotinoontalre`pmroenisteonrtinigm.meTdhiuast,e tphree-maternal
pregnancy, gestational, or immediate post-partum levels,
Worker #2 age 2. The
has two children. sample from 2000
Child A was also sampled in was: re-analyzed with impr
the
fall0f
2000,
atapproximately
Child
B
was
about
8
months
old
when
sampled
in
the
oved analytical techniques fall of 2002. Maternal values
in 2002. are
available provided
from the fall of 1998, March to offer general context.
2000,
and
June
2002,
and
as
with
worker
#1,
are
Sampling results are shown in the tables Quantification (LLOQ) of the analytical
below. For method, the
results
below
the
Lower
Limit
of
(where available) is shown in parenthesis.
`quantification limit for the chemical
(T a a
s 5
SC338B
ER
=
1
+ spe------ r en m ]
| [-- ee
efJe] ]
-- -- re J Jer]|
os, pgm
i
N-methyl perfluorooctanesulfonamidoacetate (M570) =
sr
FE,
-- a
N-cthylperfluorooctanesulfonamido(aPcFeOtSaAtAe) Nemethyl perfluoroocianesulfonamidoacetate (M370) >
ot --Eo-------------- woRkeR #2
ANALYTE
[eee roy
Npoor1t9o8 | SaiermepeTesiro | Jvaerenn [o en me|
[eee _[08__Joontea N-ethyl perfluorooctanesulfonamidoacetate (PFOSAA) | Below LLOQ | 0.020 [0.015]
N-methyl perfluorooctanesulfonamidoacetate (M370)
Tera ToraE PFOSAY
[Eee
Seow Toa | oBoanTmoaye Peerioq Jona
Jams | oon Below LLOQ
(0.057)
[oR
3M does not believe that these data meet the TSCA Section 8(e) "substantial risk" reporting
threshold. In our view, these data are limited and provide no basis to draw any scientific
ccoonncsleunstioonfst.heNtevweortwhoerlkeesrss,,
3reMcohgansizdiencgidtehde
toongsoubimnigtwtohreksebdyatUa.St.o
the 8(e)
EPA to
adsosceksest,
with
the
fluorochemical exposure pathways and potential risks.
If you have any questions, please do not hesitate to contact Dr. Larry Zobel at (651) 733-5181.
Sincerely,
gz)m=
Larry R. Zobel, MD MPH StaffVice President and Medical Director
3M Medical Department